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細胞番号 : 細胞名
RCB1976 : Ca9-22  update : 2023/01/04
細胞特性(Comment:英)Human gingival carcinoma cell line. Expressing remarkable EGF receptor. HLA-A 2/24. TKG0485 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト歯肉癌由来細胞株。EGF receptor高発現細胞。HLA-A 2/24。 TKG0485 (東北大学医用細胞資源センターからの寄託)。
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
寄託日 2004
元の細胞 TKG0485
動物種 human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
採取組織 gingiva
病名 gingival carcinoma
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0485)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_1102
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP
個体識別検査 OK
文献情報 Reference(英) 2件
Reference(日) 1件
利用者成果(英) 168件
利用者成果(日) 0件

3304  Kimura Y.  Studies on Lactate dehydrogenase isoenzymes in a cell line (Ca9-22) deribed from carcinoma of the gigiva  Kouku-byo Gakkai-shi  1978  45:20+35   
3306  orikoshi,M., Kimura,Y., Nagura,H., Ono,T., and Ito,H.  A new cell line derived from human carcinoma of the gingiva I. Its establishbint and morphological studies  Nihon Koku Geka Gakkai Zasshi  1974  20:100-106  PubMed ID: 4549822   DOI: 10.5794/jjoms.20.100

3305  Horikoshi,M., Katsumura,A., Fujibayashi,T., Soda,T., and Itoh,H.  Lymphocyte mediated cytotoxicity to tral squamous cell carcinoma cell line (Ca 9-22)  Jpn J Oral Surg  1977  5:619-625   

21172  Takizawa F, Domon H, Hiyoshi T, Tamura H, Shimizu K, Maekawa T, Tabeta K, Ushida A, Terao Y.  Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment.  PLoS One  2023  18(4):e0284115  PubMed ID: 37043490   DOI: 10.1371/journal.pone.0284115
17628  Le MN, Wuertz BR, Biel MA, Thompson RL, Ondrey FG.  Effects of methylene blue photodynamic therapy on oral carcinoma and leukoplakia cells  Laryngoscope Investig Otolaryngol  2022  7(4):982-987  PubMed ID: 36000031   DOI: 10.1002/lio2.772
20565  Mezawa M, Tsuruya Y, Yamaguchi A, Yamazaki-Takai M, Kono T, Okada H, McCulloch CA, Ogata Y.  TNF-α regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells.  Cell Adh Migr  2022  16(1):13-24  PubMed ID: 35137648   DOI: 10.1080/19336918.2022.2029237
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748   DOI: 10.3390/ijms23052601
16528  Nyui T, Yoshino H, Nunota T, Sato Y, Tsuruga E.  cGAS Regulates the Radioresistance of Human Head and Neck Squamous Cell Carcinoma Cells  Cells  2022  11(9):1434  PubMed ID: 35563740   DOI: 10.3390/cells11091434
20734  Yokogawa T, Nagano K, Fujita M, Miyakawa H, Iijima M.  Characterization of a Treponema denticola ATCC 35405 mutant strain with mutation accumulation, including a lack of phage-derived genes.  PLoS One  2022  17(6):e0270198  PubMed ID: 35749516   DOI: 10.1371/journal.pone.0270198
20815  Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR.  Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells.  Medicines (Basel)  2022  9(6)  PubMed ID: 35736248   DOI: 10.3390/medicines9060035
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20964  Uemichi K, Mikami Y, Watanabe T, Shinozuka K, Tonogi M, Tsuda H.  Histone-deacetylase-inhibitory effects of periodontopathic-bacterial metabolites induce human gingival epithelial Ca9-22 cell death.  Odontology  2022    PubMed ID: 36482237   DOI: 10.1007/s10266-022-00775-9
13402  Fujiwara Y, Murofushi T, Koshi R, Mikami Y, Tsuda H.  Reactive oxygen species-dependent release of damage-associated molecular patterns from human gingival epithelial Ca9-22 cells during butyrate or propionate exposure.  J Oral Sci  2021  63(2):195-197  PubMed ID: 33390461   DOI: 10.2334/josnusd.20-0411
20085  Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H.  Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.  Sci Rep  2021  11(1):5897  PubMed ID: 33723306   DOI: 10.1038/s41598-021-85242-1
20181  Semlali A, Contant C, Al-Otaibi B, Al-Jammaz I, Chandad F.  The curcumin analog (PAC) suppressed cell survival and induced apoptosis and autophagy in oral cancer cells.  Sci Rep  2021  11(1):11701  PubMed ID: 34083581   DOI: 10.1038/s41598-021-90754-x
20201  Semlali A, Beji S, Ajala I, Rouabhia M.  Effects of tetrahydrocannabinols on human oral cancer cell proliferation, apoptosis, autophagy, oxidative stress, and DNA damage.  Arch Oral Biol  2021  129:105200  PubMed ID: 34146926   DOI: 10.1016/j.archoralbio.2021.105200
20206  Contant C, Rouabhia M, Loubaki L, Chandad F, Semlali A.  Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways.  Sci Rep  2021  11(1):13087  PubMed ID: 34158560   DOI: 10.1038/s41598-021-92456-w
20314  Mineo S, Takahashi N, Yamada-Hara M, Tsuzuno T, Aoki-Nonaka Y, Tabeta K.  Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells.  Arch Oral Biol  2021  129:105215  PubMed ID: 34325345   DOI: 10.1016/j.archoralbio.2021.105215
20350  Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI.  Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression.  Transl Oncol  2021  14(12):101236  PubMed ID: 34624685   DOI: 10.1016/j.tranon.2021.101236
15648  Ishikawa T, Sugawara S, Kihara H, Hanasaka T, Hatakeyama W, Sasaki M, Kondo H.  Titanium nanoparticles potentially affect gingival tissue through IL-13α2 receptor expression  J Oral Sci  2021  63(3):263-266  PubMed ID: 34039830   DOI: 10.2334/josnusd.21-0130
20432  Fukuda H, Sato S, Zou T, Higashi S, Takahashi O, Habu M, Sasaguri M, Tominaga K, Takenaka S, Takeuchi H.  Substituent effects of cyclic naphthalene diimide on G-quadruplex binding and the inhibition of cancer cell growth.  Bioorg Med Chem Lett  2021  50:128323  PubMed ID: 34400300   DOI: 10.1016/j.bmcl.2021.128323
20438  Yang KH, Tang JY, Chen YN, Chuang YT, Tsai IH, Chiu CC, Li LJ, Chien TM, Cheng YB, Chang FR, Yen CY, Chang HW.  Nepenthes Extract Induces Selective Killing, Necrosis, and Apoptosis in Oral Cancer Cells.  J Pers Med  2021  11(9)  PubMed ID: 34575651   DOI: 10.3390/jpm11090871
15888  Abeer Aljubailah, Wafa Nazzal Odis Alharbi, Ahmed S. Haidyrah, Tahani Saad Al-Garni, Waseem Sharaf Saeed, Abdelhabib Semlali, Saad M. S. Alqahtani, Ahmad Abdulaziz Al-Owais, Abdulnasser Mahmoud Karami, Taieb Aouak  Copolymer Involving 2-Hydroxyethyl Methacrylate and 2-Chloroquinyl Methacrylate: Synthesis, Characterization and In Vitro 2-Hydroxychloroquine Delivery Application  Polymers  2021  13:4072  PubMed ID: 34883576   DOI: 10.3390/polym13234072
20466  Kawahara K, Nagata M, Yoshida R, Hirosue A, Tanaka T, Matsuoka Y, Arita H, Nakashima H, Sakata J, Yamana K, Kawaguchi S, Gohara S, Nagao Y, Hirayama M, Takahashi N, Hirayama M, Nakayama H.  miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma.  Biochem Biophys Rep  2021  28:101114  PubMed ID: 34589618   DOI: 10.1016/j.bbrep.2021.101114
16099  Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E.  PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1  Int J Oncol  2021  58(6):29  PubMed ID: 33887877   DOI: 10.3892/ijo.2021.5209
16112  Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M.  Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells  Oral Surg Oral Med Oral Pathol Oral Radiol  2021  132(5):549-565  PubMed ID: 34518137   DOI: 10.1016/j.oooo.2021.04.006
16125  Liu SL, Yang KH, Yang CW, Lee MY, Chuang YT, Chen YN, Chang FR, Chen CY, Chang HW.  Burmannic Acid Inhibits Proliferation and Induces Oxidative Stress Response of Oral Cancer Cells  Antioxidants (Basel)  2021  10(10):1588  PubMed ID: 34679723   DOI: 10.3390/antiox10101588
16139  Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma  Int J Mol Sci   2021  22(23):12684  PubMed ID: 34884487   DOI: 10.3390/ijms222312684
16140  Sato K, Iwasaki S, Yoshino H.  Effects and Related Mechanisms of the Senolytic Agent ABT-263 on the Survival of Irradiated A549 and Ca9-22 Cancer Cells  Int J Mol Sci   2021  22(24):13233  PubMed ID: 34948029   DOI: 10.3390/ijms222413233
16174  Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U.  Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts  Molecules  2021  26(23):7132  PubMed ID: 34885719   DOI: 10.3390/molecules26237132
16196  Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S.  Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue  Medicines (Basel)  2021  8(7):33  PubMed ID: 34206186   DOI: 10.3390/medicines8070033
16200  Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR.  Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring  Medicines (Basel)  2021  8(12):78  PubMed ID: 34940290   DOI: 10.3390/medicines8120078
16206  Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma  Int J Mol Sci  2021  22(18):9947  PubMed ID: 34576110   DOI: 10.3390/ijms22189947
16862  Kawasaki M, Sakabe T, Kodani I, Umekita Y.  Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma  Anticancer Res  2021  41(9):4563-4570  PubMed ID: 34475084   DOI: 10.21873/anticanres.15269
16975  Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K.  Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling  Anticancer Res  2021  41(4):1821-1830  PubMed ID: 33813387   DOI: 10.21873/anticanres.14948
11761  Choi GE, Hyun KY.  Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis.  Arch. Oral Biol.  2020  109:104529  PubMed ID: 31574324   DOI: 10.1016/j.archoralbio.2019.104529
11844  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Oral Dis  2020  26(4):745-755  PubMed ID: 31603606   DOI: 10.1111/odi.13210
6954  Hayashi H, Chiba T, Mihara-Tomiyama N, Negishi T, Kodama Y, Sakashita H, Imai K.  Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear localization in oral carcinoma cells and the proliferation inhibition.  Biochem Biophys Res Commun  2020  522(3):799-804  PubMed ID: 31791579   DOI: 10.1016/j.bbrc.2019.11.171
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870   DOI: 10.1016/j.heliyon.2020.e03301
12091  Higaki M, Shintani T, Hamada A, Rosli SNZ, Okamoto T.  Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1).  In Vitro Cell. Dev. Biol. Anim.  2020    PubMed ID: 32185608   DOI: 10.1007/s11626-020-00440-x
12128  Hazawa M, Yoshino H, Nakagawa Y, Shimizume R, Nitta K, Sato Y, Sato M, Wong RW, Kashiwakura I.  Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines.  Cancers (Basel)  2020    PubMed ID: 32276424   DOI: 10.3390/cancers12040908
12166  Yuichi Ohnishi Tsukasa Sakamoto Li Zhengguang Hiroki Yasui Hiroyuki Hamada Hirohito Kubo Masahiro Nakajima  Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade  Oncology Letter  2020    PubMed ID: 32391111   DOI: 10.3892/ol.2020.11523
12997  Oda M, Kurosawa M, Yamamoto H, Domon H, Takenaka S, Ohsumi T, Maekawa T, Yamasaki N, Furue Y, Terao Y.  Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans.  Microbiol Immunol  2020    PubMed ID: 32320095   DOI: 10.1111/1348-0421.12797
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607   DOI: 10.21873/anticanres.14357
13148  Tang JY, Wu KH, Wang YY, Farooqi AA, Huang HW, Yuan SF, Jian RI, Tsao LY, Chen PA, Chang FR, Cheng YB, Hu HC, Chang HW.  Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress.  Antioxidants (Basel)  2020    PubMed ID: 32756347   DOI: 10.3390/antiox9080694
13172  Li XH, Li D, Liu C, Zhang MM, Guan XJ, Fu YP.  p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2.  Cancer Cell Int  2020    PubMed ID: 32831651   DOI: 10.1186/s12935-020-01489-0
13205  Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H.  Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro.  Anticancer Res  2020    PubMed ID: 32878776   DOI: 10.21873/anticanres.14491
13362  Hasegawa T, Takenaka S, Oda M, Domon H, Hiyoshi T, Sasagawa K, Ohsumi T, Hayashi N, Okamoto Y, Yamamoto H, Ohshima H, Terao Y, Noiri Y.  Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability.  BMC Microbiol  2020    PubMed ID: 33238885   DOI: 10.1186/s12866-020-02033-w
13781  Yamazaki M, Maruyama S, Abé T, Tsuneki M, Kato H, Izumi K, Tanuma JI, Cheng J, Saku T.  Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression  Exp Cell Res  2020  392(1):112013  PubMed ID: 32320683   DOI: 10.1016/j.yexcr.2020.112013
13903  Aika Tanzawa et al.  Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma  Oral Science International  2020  17(2):67-72    DOI: 10.1002/osi2.1044
13921  Abdelhabib Semlali et al  The Curcumin Analog (PAC) Has Anti-Oral Cancer Properties Through Impairing Pro-Survival Signaling Pathways and Activating the Cell Death Processes Apoptosis and Autophagy  Research Square  2020      DOI: 10.21203/rs.3.rs-128652/v1
13929  Mizutani Y, Omagari D, Hayatsu M, Nameta M, Komiyama K, Mikami Y, Ushiki T.  SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role  Cell Adh Migr  2020  14(1):195-203  PubMed ID: 33016205   DOI: 10.1080/19336918.2020.1829264
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341   DOI: 10.1016/j.bbrc.2018.12.066
11377  Inoue K, Hatano K, Hanamatsu Y, Saigo C, Kito Y, Bunai K, Shibata T, Takeuchi T.  Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma.  J. Cancer Res. Clin. Oncol.  2019    PubMed ID: 30635792   DOI: 10.1007/s00432-019-02843-0
11497  Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S.  Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells.  J. Biochem.  2019    PubMed ID: 30918974   DOI: 10.1093/jb/mvz024
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826   DOI: 10.1038/s41586-019-1103-9
11566  Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y.  Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria that predominate in the oral cavity and upper airways.  Microbiol. Immunol.  2019    PubMed ID: 31106894   DOI: 10.1111/1348-0421.12688
11584  Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW.  Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress.  Environ. Toxicol.  2019    PubMed ID: 31157515   DOI: 10.1002/tox.22748
11590  Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW.  Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells.  DNA Cell Biol.  2019    PubMed ID: 31170002   DOI: 10.1089/dna.2018.4436
11620  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Anticancer Res.  2019    PubMed ID: 31262875   DOI: 10.21873/anticanres.13497
11878  Watanabe N, Nodomi K, Koike R, Kato A, Takeichi O, Kotani AI, Kaneko T, Sakagami H, Takei M, Ogata Y, Sato S, Imai K.  EBV LMP1 in Gingival Epithelium Potentially Contributes to Human Chronic Periodontitis via Inducible IL8 Production.  In Vivo  2019    PubMed ID: 31662504   DOI: 10.21873/invivo.11670
9696  Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa  Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma  Exp Cell Res  2019  384(2):111622  PubMed ID: 31518558   DOI: 10.1016/j.yexcr.2019.111622
9726  Mohamed A A Orabi, Esam A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano   Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl ( m-GO- m-GOG)-Type Ellagitannins From the Galls of Tamarix aphylla  J Nat Prod  2019  82(10):2682-2695  PubMed ID: 31532650   DOI: 10.1021/acs.jnatprod.9b00073
11907  Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M.  Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review.  Dis. Markers  2019    PubMed ID: 31019584   DOI: 10.1155/2019/8040361
11931  Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs.  Anticancer Res.  2019    PubMed ID: 31810932   DOI: 10.21873/anticanres.13882
11933  Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones.  Anticancer Res.  2019    PubMed ID: 31810912   DOI: 10.21873/anticanres.13862
12457  Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  SYT12 plays a critical role in oral cancer and may be a novel therapeutic target  J Cancer  2019  10(20):4913-4920  PubMed ID: 31598163   DOI: 10.7150/jca.32582
12586  Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S.  Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner  J Clin Biochem Nutr  2019  65(1):8-15  PubMed ID: 31379408   DOI: 10.3164/jcbn.18-91
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705   DOI: 10.1016/j.bbrc.2017.12.138
10683  Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H.  Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.  Biochem. Biophys. Res. Commun.  2018  495:2303-2309  PubMed ID: 29278708   DOI: 10.1016/j.bbrc.2017.12.136
10724  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707   DOI: 10.21873/anticanres.12289
10727  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.  Anticancer Res.  2018  38:763-770  PubMed ID: 29374700   DOI: 10.21873/anticanres.12282
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312   DOI: 10.1016/j.yexcr.2018.03.041
10820  Fukamachi M, Kasamatsu A, Endo-Sakamoto Y, Fushimi K, Kasama H, Iyoda M, Minakawa Y, Shiiba M, Tanzawa H, Uzawa K.  Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.  Exp. Cell Res.  2018  368:119-125  PubMed ID: 29679592   DOI: 10.1016/j.yexcr.2018.04.021
10829  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  In Vivo  2018  32:479-486  PubMed ID: 29695549   DOI: 10.21873/invivo.11264
11086  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Anticancer Res.  2018  38(6):3283-3290  PubMed ID: 29848675   DOI: 10.21873/anticanres.12593
11147  Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.  Anticancer Res.  2018  38(8):4449-4457  PubMed ID: 30061209   DOI: 10.21873/anticanres.12747
11148  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210   DOI: 10.21873/anticanres.12748
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493   DOI: 10.7150/jca.25666
4078  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Medicinal Chemistry Research  2018  27:2366–2378    DOI: 10.1007/s00044-018-2242-5
4172  Tamai R, Kobayashi-Sakamoto M, Kiyoura Y.  Extracellular galectin-1 enhances adhesion to and invasion of oral epithelial cells by Porphyromonas gingivalis.  Can. J. Microbiol.  2018    PubMed ID: 29544077   DOI: 10.1139/cjm-2017-0461
4173  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  In Vivo  2018    PubMed ID: 29695558   DOI: 10.21873/invivo.11273
4236  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Oncol. Rep.  2018    PubMed ID: 29192320   DOI: 10.3892/or.2017.6105
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845   DOI: 10.3892/mco.2018.1548
4345  Hou B, Ishinaga H, Midorikawa K, Nakamura S, Hiraku Y, Oikawa S, Ma N, Takeuchi K, Murata M.  Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2.  Oncotarget  2018    PubMed ID: 29507664   DOI: 10.18632/oncotarget.23826
16201  Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K.  Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer  Lab Invest  2018  98(8):980-988  PubMed ID: 29855544   DOI: 10.1038/s41374-018-0070-3
16207  Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato , Susumu Nakata, Yasushi Yatabe, Mitsuo Goto, Norio Kaneda , Kenichi Kurita, Hayao Nakanishi, Kenji Yoshida  A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green-Labeled Podoplanin Antibody  Technol Cancer Res Treat  2018  1533033818767936.  PubMed ID: 29649929   DOI: 10.1177/1533033818767936
9835  Evans M, Murofushi T, Tsuda H, Mikami Y, Zhao N, Ochiai K, Kurita-Ochiai T, Yamamoto M, Otsuka K, Suzuki N.  Combined effects of starvation and butyrate on autophagy-dependent gingival epithelial cell death.  J. Periodont. Res.  2017  52:522-531  PubMed ID: 27624546   DOI: 10.1111/jre.12418
9915  Tsubaki M, Fujiwara D, Takeda T, Kino T, Tomonari Y, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S.  The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.  Clin. Exp. Pharmacol. Physiol.  2017  44:222-234  PubMed ID: 27805296   DOI: 10.1111/1440-1681.12690
9962  Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F.  Comparative analysis of motility and other properties of Treponema denticola strains.  Microb. Pathog.  2017  102:82-88  PubMed ID: 27914958   DOI: 10.1016/j.micpath.2016.11.021
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246   DOI: 10.1016/j.yexcr.2017.02.026
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172   DOI: 10.1038/srep43379
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328   DOI: 10.1016/j.bbrc.2017.03.050
10197  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260   DOI: 10.21873/anticanres.11412
10201  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269   DOI: 10.21873/anticanres.11421
10206  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Molecules  2017  22:  PubMed ID: 28294988   DOI: 10.3390/molecules22030470
10241  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677   DOI: 10.1248/cpb.c16-00830
10344  Takada A, Matsushita K, Horioka S, Furuichi Y, Sumi Y.  Bactericidal effects of 310 nm ultraviolet light-emitting diode irradiation on oral bacteria.  BMC Oral Health  2017  17:96  PubMed ID: 28587675   DOI: 10.1186/s12903-017-0382-5
10377  Takamura T, Suguro H, Mikami Y, Iwase T, Komiyama Y, Kuyama K, Komiyama K, Oki H.  Comparison of gene expression profiles of gingival carcinoma Ca9-22 cells and colorectal adenocarcinoma HT-29 cells to identify potentially important mediators of SLPI-induced cell migration.  J Oral Sci  2017  59:279-287  PubMed ID: 28637988   DOI: 10.2334/josnusd.16-0534
10386  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  In Vivo  2017  31:591-598  PubMed ID: 28652425   DOI: 10.21873/invivo.11099
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404   DOI: 10.7150/jca.18714
10517  Murofushi T, Tsuda H, Mikami Y, Yamaguchi Y, Suzuki N.  CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.  J Oral Sci  2017  59:415-423  PubMed ID: 28904318   DOI: 10.2334/josnusd.16-0696
10526  Ohno T, Yamamoto G, Hayashi JI, Nishida E, Goto H, Sasaki Y, Kikuchi T, Fukuda M, Hasegawa Y, Mogi M, Mitani A.  Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells.  PLoS ONE  2017  12:e0184825  PubMed ID: 28934245   DOI: 10.1371/journal.pone.0184825
10572  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798   DOI: 10.21873/anticanres.12066
10576  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797   DOI: 10.21873/anticanres.12065
10937    Effect of Micro/Nano-Patterned Surfaces on Cell Adhesion of Ca9-22 cells  e-J. Surf. Sci. Nanotech.  2017  15 : 1-6    DOI: 10.1380/ejssnt.2017.1
10958    Inactivation of dermatopontin via histone deacetylation in human oral cancer  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2017  29, 400-404    DOI: 10.1016/j.ajoms.2017.03.013
4574  Yasui H, Ohnishi Y, Nakajima M, Nozaki M.  Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.  Oncol Rep  2017  37(6):3674-3680  PubMed ID: 28440510   DOI: 10.3892/or.2017.5587
6027  lNorihisa Ichimura et al  Notch3 is frequently downregulated in oral cancer  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2017  29:504-510    DOI: 10.1016/j.ajoms.2017.06.006
6641  Mariko Kawai, Kiyoshi Ohura  A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants  Open Journal of Stomatology  2017  7:494-500    DOI: 10.4236/ojst.2017.711046
12679  Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K.  Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential  Cancer Res  2017  77(9):2363-2374  PubMed ID: 28209617   DOI: 10.1158/0008-5472.CAN-16-2114
14613  Nagai K, Domon H, Oda M, Shirai T, Ohsumi T, Terao Y, Arai Y.  Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria  Dent Mater J  2017  36(6):784-790  PubMed ID: 28747597   DOI: 10.4012/dmj.2016-321
7139  Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y.  Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans.  Microbiol. Immunol.  2016  60:10-6  PubMed ID: 26600203   DOI: 10.1111/1348-0421.12343
7181  Gojoubori T, Ota H, Kusunoki M, Nishio Y, Nishio K, Iwasa S, Kaneko Y, Asano M.  Electrolytically generated acid functional water inhibits NF-κB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits.  J. Recept. Signal Transduct. Res.  2016  36:248-53  PubMed ID: 26480200   DOI: 10.3109/10799893.2015.1086883
9558  Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K.  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.  J. Oral Pathol. Med.  2016  45:730-739  PubMed ID: 26850833   DOI: 10.1111/jop.12430
9584  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  In Vivo  2016  30:91-7  PubMed ID: 26912818  
9604  Chang HS, Tang JY, Yen CY, Huang HW, Wu CY, Chung YA, Wang HR, Chen IS, Huang MY, Chang HW.  Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage.  BMC Complement Altern Med  2016  16:94  PubMed ID: 26955958   DOI: 10.1186/s12906-016-1073-5
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959   DOI: 10.7150/jca.13820
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852   DOI: 10.7150/jca.14208
9702  Mikami Y, Fukushima A, Komiyama Y, Iwase T, Tsuda H, Higuchi Y, Hayakawa S, Kuyama K, Komiyama K.  Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion.  Cancer Lett.  2016  379:84-93  PubMed ID: 27238568   DOI: 10.1016/j.canlet.2016.05.028
9762  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818   DOI: 10.1371/journal.pone.0159693
9783  Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K.  Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth.  PLoS ONE  2016  11:e0161163  PubMed ID: 27512993   DOI: 10.1371/journal.pone.0161163
9808  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  In Vivo  2016  30:645-50  PubMed ID: 27566085  
9892  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902   DOI: 10.21873/anticanres.11164
9911  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  Antiviral and Antitumor Activity of Licorice Root Extracts.  In Vivo  2016  30:777-785  PubMed ID: 27815461   DOI: 10.21873/invivo.10994
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916   DOI: 10.3892/ijo.2015.3305
12609  Usui M, Sato T, Yamamoto G, Okamatsu Y, Hanatani T, Moritani Y, Sano K, Yamamoto M, Nakashima K.  Gingival epithelial cells support osteoclastogenesis by producing receptor activator of nuclear factor kappa B ligand via protein kinase A signaling  J Periodontal Res  2016  51(4):462-70  PubMed ID: 26432443   DOI: 10.1111/jre.12323
14581  Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, Kishi Y, Hamada Y, Masutani M.  Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo  Int J Mol Sci  2016  17(3):272  PubMed ID: 26927065   DOI: 10.3390/ijms17030272
7196  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690  
5422  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695  
6043  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471   DOI: 10.1016/j.toxrep.2015.09.009
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921   DOI: 10.1186/s12885-015-1577-2
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377   DOI: 10.1371/journal.pone.0142252
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920   DOI: 10.1371/journal.pone.0137923
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166   DOI: 10.1016/j.bbrep.2015.07.008
6054  Baba T et al  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483   DOI: 10.1002/mc.22127
6058  Shida-Sakazume T et al  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864   DOI: 10.1371/journal.pone.0120143
15042  Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer  Cancer Med  2015  4(5):759-69  PubMed ID: 25644496   DOI: 10.1002/cam4.418
10887  Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Okabe E, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A.  Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression  PLoS One  2015  10(10):e0140942  PubMed ID: 26474296   DOI: 10.1371/journal.pone.0140942
6006  Ohnishi Y, Watanabe M, Yasui H, Kakudo K.  Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines.  Oncol Lett  2014  7(5):1439-1442  PubMed ID: 24765152   DOI: 10.3892/ol.2014.1946
5916  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  In Vivo  2014  28(4):549-56  PubMed ID: 24982221  
5807  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906  
5778  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469   DOI: 10.1002/mc.22007
5659  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035  
5544  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367  
5337  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069  
5315  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705  
9145  Yuki Abiko, Keiji Nagano 1, Yasuo Yoshida 1, Fuminobu Yoshimura 1  Characterization of Treponema Denticola Mutants Defective in the Major Antigenic Proteins, Msp and TmpC  PLoS One  2014  9 (11), e113565  PubMed ID: 25401769   DOI: 10.1371/journal.pone.0113565
10944  Yuki Abiko, Keiji Nagano, Yasuo Yoshida, Fuminobu Yoshimura  Major Membrane Protein TDE2508 Regulates Adhesive Potency in Treponema Denticola  PLoS One  2014  9(2):e89051  PubMed ID: 24586498   DOI: 10.1371/journal.pone.0089051
16005  Kato Y, Hagiwara M, Ishihara Y, Isoda R, Sugiura S, Komatsu T, Ishida N, Noguchi T, Matsushita K.  TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1  BMC Microbiol  2014  14:229  PubMed ID: 25179218   DOI: 10.1186/s12866-014-0229-z
5028  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234   DOI: 10.1007/s00432-012-1361-5
6067  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766   DOI: 10.3892/ijo.2012.1677
6070  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790   DOI: 10.1007/s00432-012-1356-2
6072  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564   DOI: 10.1371/journal.pone.0056381
6074  Shimizu F1, Shiiba M2, Ogawara K3, Kimura R1, Minakawa Y1, Baba T1, Yokota S, Nakashima D1, Higo M3, Kasamatsu A3, Sakamoto Y3, Tanzawa H4, Uzawa K4.  Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer.  PLoS One  2013  8(12):e83187  PubMed ID: 24386158   DOI: 10.1371/journal.pone.0083187
6076  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490   DOI: 10.1371/journal.pone.0085951
6077  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247   DOI: 10.1111/j.1600-0714.2012.01182.x
6078  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548   DOI: 10.1007/s10719-012-9458-2
6081  Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.  BMC Cancer  2013  13:555  PubMed ID: 24261884   DOI: 10.1186/1471-2407-13-555
13736  Ohno M, Ueki J, Sakagami H, Wakabayashi H.  Cytotoxic activity of benzo[b]cyclohept[e][1,4]oxazines  In Vivo  2013  27(4):507-12  PubMed ID: 23812221  
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
7722  Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K.  Comprehensive epigenetic analysis using oral rinse samples: a pilot study.  J. Oral Maxillofac. Surg.  2012  70:1486-94  PubMed ID: 21821326   DOI: 10.1016/j.joms.2011.04.021
6087  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889   DOI: 10.2334/josnusd.54.71
6088  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311   DOI: 10.1002/path.3993
6089  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  J Oral Sci  2012  54(3):241-50  PubMed ID: 23047035   DOI: 10.2334/josnusd.54.241
6095  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894   DOI: 10.3892/ol.2011.473
6096  Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A.  Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms.  Lab Invest  2012  92(5):688-702  PubMed ID: 22330335   DOI: 10.1038/labinvest.2012.9
7756  Tamai R, Sugamata M, Kiyoura Y.  Candida albicans enhances invasion of human gingival epithelial cells and gingival fibroblasts by Porphyromonas gingivalis.  Microb. Pathog.  2011  51:250-4  PubMed ID: 21742026   DOI: 10.1016/j.micpath.2011.06.009
8205  Mori Y, Yano F, Shimohata N, Suzuki S, Chung UI, Takato T.  Trehalose inhibits oral dryness by protecting the cell membrane.  Int J Oral Maxillofac Surg  2010  39:916-21  PubMed ID: 20605407   DOI: 10.1016/j.ijom.2010.04.047
6120  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673   DOI: 10.1016/j.bbrc.2009.12.156
6123  Yuji Miyazaki et al  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  J Cancer Sci Ther  2010  2(2) :26-32   


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