CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1976 : Ca9-22]

3304 Kimura Y. Studies on Lactate dehydrogenase isoenzymes in a cell line (Ca9-22) deribed from carcinoma of the gigiva Kouku-byo Gakkai-shi 1978 45:20+35

3306 orikoshi,M., Kimura,Y., Nagura,H., Ono,T., and Ito,H. A new cell line derived from human carcinoma of the gingiva I. Its establishbint and morphological studies Nihon Koku Geka Gakkai Zasshi 1974 20:100-106 PubMed ID: 4549822 DOI: 10.5794/jjoms.20.100

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21577 Al Awadh AA, Sakagami H, Amano S, Sayed AM, Abouelela ME, Alhasaniah AH, Aldabaan N, Refaey MS, Abdelhamid RA, Khalil HMA, Hamdan DI, Abdel-Sattar ES, Orabi MAA. In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations. Front Pharmacol 2024 15:1325272 PubMed ID: 38303989 DOI: 10.3389/fphar.2024.1325272

21578 Papadakos S, Issa H, Alamri A, Alamri A, Semlali A. Rapamycin as a Potential Alternative Drug for Squamous Cell Gingiva Carcinoma (Ca9-22): A Focus on Cell Cycle, Apoptosis and Autophagy Genetic Profile. Pharmaceuticals (Basel) 2024 17(1) PubMed ID: 38276004 DOI: 10.3390/ph17010131

19759 Takanori Takenawa, Koji Harada, Tarannum Ferdous, Keisuke Kawasaki, Yasuhiro Kuramitsu, Katsuaki Mishima Silencing of Tropomyosin 1 suppresses the proliferation, invasion and metastasis of oral squamous cell carcinoma in vitro Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023 35:282-287 DOI: 10.1016/j.ajoms.2022.10.004

19822 Nakashiro KI, Tokuzen N, Saika M, Shirai H, Kuribayashi N, Goda H, Uchida D. MicroRNA-1289 Functions as a Novel Tumor Suppressor in Oral Squamous Cell Carcinoma Cancers (Basel) 2023 15(16):4138 PubMed ID: 37627167 DOI: 10.3390/cancers15164138

19875 Abe T, Sakagami H, Amano S, Uota S, Bandow K, Uesawa Y, U S, Shibata H, Takemura Y, Kimura Y, Takao K, Sugita Y, Sato A, Tanuma SI, Takeshima H. A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs Medicines (Basel) 2023 10(7):43 PubMed ID: 37505064 DOI: 10.3390/medicines10070043

21172 Takizawa F, Domon H, Hiyoshi T, Tamura H, Shimizu K, Maekawa T, Tabeta K, Ushida A, Terao Y. Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment. PLoS One 2023 18(4):e0284115 PubMed ID: 37043490 DOI: 10.1371/journal.pone.0284115

21251 Semlali A, Ajala I, Beji S, Al-Zharani MM, Rouabhia M. Synergistic Effect of Anethole and Platinum Drug Cisplatin against Oral Cancer Cell Growth and Migration by Inhibiting MAPKase, Beta-Catenin, and NF-κB Pathways. Pharmaceuticals (Basel) 2023 16(5) PubMed ID: 37242484 DOI: 10.3390/ph16050700

21286 Semlali A, Beji S, Ajala I, Al-Zharani M, Rouabhia M. Synergistic Effects of New Curcumin Analog (PAC) and Cisplatin on Oral Cancer Therapy. Curr Issues Mol Biol 2023 45(6):5018-5035 PubMed ID: 37367068 DOI: 10.3390/cimb45060319

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

21402 Sato K, Yoshino H, Sato Y, Nakano M, Tsuruga E. ΔNp63 Regulates Radioresistance in Human Head and Neck Squamous Carcinoma Cells. Curr Issues Mol Biol 2023 45(8):6262-6271 PubMed ID: 37623213 DOI: 10.3390/cimb45080394

21527 Orabi MAA, Orabi EA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Sakagami H, Hatano T. New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines. Antioxidants (Basel) 2023 12(11) PubMed ID: 38001804 DOI: 10.3390/antiox12111951

17628 Le MN, Wuertz BR, Biel MA, Thompson RL, Ondrey FG. Effects of methylene blue photodynamic therapy on oral carcinoma and leukoplakia cells Laryngoscope Investig Otolaryngol 2022 7(4):982-987 PubMed ID: 36000031 DOI: 10.1002/lio2.772

18100 Semlali A, Papadakos S, Contant C, Zouaoui I, Rouabhia M. Rapamycin inhibits oral cancer cell growth by promoting oxidative stress and suppressing ERK1/2, NF-κB and beta-catenin pathways Front Oncol 2022 12:873447 PubMed ID: 36185289 DOI: 10.3389/fonc.2022.873447

20565 Mezawa M, Tsuruya Y, Yamaguchi A, Yamazaki-Takai M, Kono T, Okada H, McCulloch CA, Ogata Y. TNF-α regulates the composition of the basal lamina and cell-matrix adhesions in gingival epithelial cells. Cell Adh Migr 2022 16(1):13-24 PubMed ID: 35137648 DOI: 10.1080/19336918.2022.2029237

20648 Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H. Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives. Int J Mol Sci 2022 23(5) PubMed ID: 35269748 DOI: 10.3390/ijms23052601

16528 Nyui T, Yoshino H, Nunota T, Sato Y, Tsuruga E. cGAS Regulates the Radioresistance of Human Head and Neck Squamous Cell Carcinoma Cells Cells 2022 11(9):1434 PubMed ID: 35563740 DOI: 10.3390/cells11091434

20734 Yokogawa T, Nagano K, Fujita M, Miyakawa H, Iijima M. Characterization of a Treponema denticola ATCC 35405 mutant strain with mutation accumulation, including a lack of phage-derived genes. PLoS One 2022 17(6):e0270198 PubMed ID: 35749516 DOI: 10.1371/journal.pone.0270198

20815 Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR. Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells. Medicines (Basel) 2022 9(6) PubMed ID: 35736248 DOI: 10.3390/medicines9060035

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20964 Uemichi K, Mikami Y, Watanabe T, Shinozuka K, Tonogi M, Tsuda H. Histone-deacetylase-inhibitory effects of periodontopathic-bacterial metabolites induce human gingival epithelial Ca9-22 cell death. Odontology 2022 PubMed ID: 36482237 DOI: 10.1007/s10266-022-00775-9

18213 Avincsal MO, Kamizaki K, Jimbo N, Shinomiya H, Nibu KI, Nishita M, Minami Y. Oncogenic E6 and/or E7 proteins drive proliferation and invasion of human papilloma virus‑positive head and neck squamous cell cancer through upregulation of Ror2 expression Oncol Rep 2021 46(1):148 PubMed ID: 34080643 DOI: 10.3892/or.2021.8099

13402 Fujiwara Y, Murofushi T, Koshi R, Mikami Y, Tsuda H. Reactive oxygen species-dependent release of damage-associated molecular patterns from human gingival epithelial Ca9-22 cells during butyrate or propionate exposure. J Oral Sci 2021 63(2):195-197 PubMed ID: 33390461 DOI: 10.2334/josnusd.20-0411

20085 Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H. Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Sci Rep 2021 11(1):5897 PubMed ID: 33723306 DOI: 10.1038/s41598-021-85242-1

20181 Semlali A, Contant C, Al-Otaibi B, Al-Jammaz I, Chandad F. The curcumin analog (PAC) suppressed cell survival and induced apoptosis and autophagy in oral cancer cells. Sci Rep 2021 11(1):11701 PubMed ID: 34083581 DOI: 10.1038/s41598-021-90754-x

20201 Semlali A, Beji S, Ajala I, Rouabhia M. Effects of tetrahydrocannabinols on human oral cancer cell proliferation, apoptosis, autophagy, oxidative stress, and DNA damage. Arch Oral Biol 2021 129:105200 PubMed ID: 34146926 DOI: 10.1016/j.archoralbio.2021.105200

20206 Contant C, Rouabhia M, Loubaki L, Chandad F, Semlali A. Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways. Sci Rep 2021 11(1):13087 PubMed ID: 34158560 DOI: 10.1038/s41598-021-92456-w

20314 Mineo S, Takahashi N, Yamada-Hara M, Tsuzuno T, Aoki-Nonaka Y, Tabeta K. Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells. Arch Oral Biol 2021 129:105215 PubMed ID: 34325345 DOI: 10.1016/j.archoralbio.2021.105215

20350 Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI. Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression. Transl Oncol 2021 14(12):101236 PubMed ID: 34624685 DOI: 10.1016/j.tranon.2021.101236

15648 Ishikawa T, Sugawara S, Kihara H, Hanasaka T, Hatakeyama W, Sasaki M, Kondo H. Titanium nanoparticles potentially affect gingival tissue through IL-13α2 receptor expression J Oral Sci 2021 63(3):263-266 PubMed ID: 34039830 DOI: 10.2334/josnusd.21-0130

20432 Fukuda H, Sato S, Zou T, Higashi S, Takahashi O, Habu M, Sasaguri M, Tominaga K, Takenaka S, Takeuchi H. Substituent effects of cyclic naphthalene diimide on G-quadruplex binding and the inhibition of cancer cell growth. Bioorg Med Chem Lett 2021 50:128323 PubMed ID: 34400300 DOI: 10.1016/j.bmcl.2021.128323

20438 Yang KH, Tang JY, Chen YN, Chuang YT, Tsai IH, Chiu CC, Li LJ, Chien TM, Cheng YB, Chang FR, Yen CY, Chang HW. Nepenthes Extract Induces Selective Killing, Necrosis, and Apoptosis in Oral Cancer Cells. J Pers Med 2021 11(9) PubMed ID: 34575651 DOI: 10.3390/jpm11090871

15888 Abeer Aljubailah, Wafa Nazzal Odis Alharbi, Ahmed S. Haidyrah, Tahani Saad Al-Garni, Waseem Sharaf Saeed, Abdelhabib Semlali, Saad M. S. Alqahtani, Ahmad Abdulaziz Al-Owais, Abdulnasser Mahmoud Karami, Taieb Aouak Copolymer Involving 2-Hydroxyethyl Methacrylate and 2-Chloroquinyl Methacrylate: Synthesis, Characterization and In Vitro 2-Hydroxychloroquine Delivery Application Polymers 2021 13:4072 PubMed ID: 34883576 DOI: 10.3390/polym13234072

20466 Kawahara K, Nagata M, Yoshida R, Hirosue A, Tanaka T, Matsuoka Y, Arita H, Nakashima H, Sakata J, Yamana K, Kawaguchi S, Gohara S, Nagao Y, Hirayama M, Takahashi N, Hirayama M, Nakayama H. miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma. Biochem Biophys Rep 2021 28:101114 PubMed ID: 34589618 DOI: 10.1016/j.bbrep.2021.101114

16099 Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E. PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1 Int J Oncol 2021 58(6):29 PubMed ID: 33887877 DOI: 10.3892/ijo.2021.5209

16112 Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M. Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells Oral Surg Oral Med Oral Pathol Oral Radiol 2021 132(5):549-565 PubMed ID: 34518137 DOI: 10.1016/j.oooo.2021.04.006

16125 Liu SL, Yang KH, Yang CW, Lee MY, Chuang YT, Chen YN, Chang FR, Chen CY, Chang HW. Burmannic Acid Inhibits Proliferation and Induces Oxidative Stress Response of Oral Cancer Cells Antioxidants (Basel) 2021 10(10):1588 PubMed ID: 34679723 DOI: 10.3390/antiox10101588

16139 Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma Int J Mol Sci 2021 22(23):12684 PubMed ID: 34884487 DOI: 10.3390/ijms222312684

16140 Sato K, Iwasaki S, Yoshino H. Effects and Related Mechanisms of the Senolytic Agent ABT-263 on the Survival of Irradiated A549 and Ca9-22 Cancer Cells Int J Mol Sci 2021 22(24):13233 PubMed ID: 34948029 DOI: 10.3390/ijms222413233

16174 Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U. Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts Molecules 2021 26(23):7132 PubMed ID: 34885719 DOI: 10.3390/molecules26237132

16196 Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S. Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue Medicines (Basel) 2021 8(7):33 PubMed ID: 34206186 DOI: 10.3390/medicines8070033

16200 Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR. Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring Medicines (Basel) 2021 8(12):78 PubMed ID: 34940290 DOI: 10.3390/medicines8120078

16206 Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma Int J Mol Sci 2021 22(18):9947 PubMed ID: 34576110 DOI: 10.3390/ijms22189947

16862 Kawasaki M, Sakabe T, Kodani I, Umekita Y. Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma Anticancer Res 2021 41(9):4563-4570 PubMed ID: 34475084 DOI: 10.21873/anticanres.15269

16975 Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K. Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Res 2021 41(4):1821-1830 PubMed ID: 33813387 DOI: 10.21873/anticanres.14948

11761 Choi GE, Hyun KY. Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis. Arch. Oral Biol. 2020 109:104529 PubMed ID: 31574324 DOI: 10.1016/j.archoralbio.2019.104529

11844 Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M. CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity. Oral Dis 2020 26(4):745-755 PubMed ID: 31603606 DOI: 10.1111/odi.13210

6954 Hayashi H, Chiba T, Mihara-Tomiyama N, Negishi T, Kodama Y, Sakashita H, Imai K. Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear localization in oral carcinoma cells and the proliferation inhibition. Biochem Biophys Res Commun 2020 522(3):799-804 PubMed ID: 31791579 DOI: 10.1016/j.bbrc.2019.11.171

12037 Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H. Modification of TRPV4 activity by acetaminophen. Heliyon 2020 PubMed ID: 32051870 DOI: 10.1016/j.heliyon.2020.e03301

12091 Higaki M, Shintani T, Hamada A, Rosli SNZ, Okamoto T. Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1). In Vitro Cell. Dev. Biol. Anim. 2020 PubMed ID: 32185608 DOI: 10.1007/s11626-020-00440-x

12128 Hazawa M, Yoshino H, Nakagawa Y, Shimizume R, Nitta K, Sato Y, Sato M, Wong RW, Kashiwakura I. Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines. Cancers (Basel) 2020 PubMed ID: 32276424 DOI: 10.3390/cancers12040908

12166 Yuichi Ohnishi Tsukasa Sakamoto Li Zhengguang Hiroki Yasui Hiroyuki Hamada Hirohito Kubo Masahiro Nakajima Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade Oncology Letter 2020 PubMed ID: 32391111 DOI: 10.3892/ol.2020.11523

12997 Oda M, Kurosawa M, Yamamoto H, Domon H, Takenaka S, Ohsumi T, Maekawa T, Yamasaki N, Furue Y, Terao Y. Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans. Microbiol Immunol 2020 PubMed ID: 32320095 DOI: 10.1111/1348-0421.12797

13093 Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. Protection of Bortezomib-induced Neurotoxicity by Antioxidants. Anticancer Res 2020 PubMed ID: 32620607 DOI: 10.21873/anticanres.14357

13148 Tang JY, Wu KH, Wang YY, Farooqi AA, Huang HW, Yuan SF, Jian RI, Tsao LY, Chen PA, Chang FR, Cheng YB, Hu HC, Chang HW. Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress. Antioxidants (Basel) 2020 PubMed ID: 32756347 DOI: 10.3390/antiox9080694

13172 Li XH, Li D, Liu C, Zhang MM, Guan XJ, Fu YP. p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2. Cancer Cell Int 2020 PubMed ID: 32831651 DOI: 10.1186/s12935-020-01489-0

13205 Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H. Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro. Anticancer Res 2020 PubMed ID: 32878776 DOI: 10.21873/anticanres.14491

13362 Hasegawa T, Takenaka S, Oda M, Domon H, Hiyoshi T, Sasagawa K, Ohsumi T, Hayashi N, Okamoto Y, Yamamoto H, Ohshima H, Terao Y, Noiri Y. Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability. BMC Microbiol 2020 PubMed ID: 33238885 DOI: 10.1186/s12866-020-02033-w

13781 Yamazaki M, Maruyama S, Abé T, Tsuneki M, Kato H, Izumi K, Tanuma JI, Cheng J, Saku T. Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression Exp Cell Res 2020 392(1):112013 PubMed ID: 32320683 DOI: 10.1016/j.yexcr.2020.112013

13903 Aika Tanzawa et al. Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma Oral Science International 2020 17(2):67-72 DOI: 10.1002/osi2.1044

13921 Abdelhabib Semlali et al The Curcumin Analog (PAC) Has Anti-Oral Cancer Properties Through Impairing Pro-Survival Signaling Pathways and Activating the Cell Death Processes Apoptosis and Autophagy Research Square 2020 DOI: 10.21203/rs.3.rs-128652/v1

13929 Mizutani Y, Omagari D, Hayatsu M, Nameta M, Komiyama K, Mikami Y, Ushiki T. SLPI facilitates cell migration by regulating lamellipodia/ruffles and desmosomes, in which Galectin4 plays an important role Cell Adh Migr 2020 14(1):195-203 PubMed ID: 33016205 DOI: 10.1080/19336918.2020.1829264

11354 Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K. Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30587341 DOI: 10.1016/j.bbrc.2018.12.066

11377 Inoue K, Hatano K, Hanamatsu Y, Saigo C, Kito Y, Bunai K, Shibata T, Takeuchi T. Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma. J. Cancer Res. Clin. Oncol. 2019 PubMed ID: 30635792 DOI: 10.1007/s00432-019-02843-0

11497 Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S. Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells. J. Biochem. 2019 PubMed ID: 30918974 DOI: 10.1093/jb/mvz024

11511 Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature 2019 PubMed ID: 30971826 DOI: 10.1038/s41586-019-1103-9

11566 Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y. Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria that predominate in the oral cavity and upper airways. Microbiol. Immunol. 2019 PubMed ID: 31106894 DOI: 10.1111/1348-0421.12688

11584 Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW. Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress. Environ. Toxicol. 2019 PubMed ID: 31157515 DOI: 10.1002/tox.22748

11590 Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW. Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells. DNA Cell Biol. 2019 PubMed ID: 31170002 DOI: 10.1089/dna.2018.4436

11620 Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H. Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives. Anticancer Res. 2019 PubMed ID: 31262875 DOI: 10.21873/anticanres.13497

11878 Watanabe N, Nodomi K, Koike R, Kato A, Takeichi O, Kotani AI, Kaneko T, Sakagami H, Takei M, Ogata Y, Sato S, Imai K. EBV LMP1 in Gingival Epithelium Potentially Contributes to Human Chronic Periodontitis via Inducible IL8 Production. In Vivo 2019 PubMed ID: 31662504 DOI: 10.21873/invivo.11670

9696 Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma Exp Cell Res 2019 384(2):111622 PubMed ID: 31518558 DOI: 10.1016/j.yexcr.2019.111622

9726 Mohamed A A Orabi, Esam A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl ( m-GO- m-GOG)-Type Ellagitannins From the Galls of Tamarix aphylla J Nat Prod 2019 82(10):2682-2695 PubMed ID: 31532650 DOI: 10.1021/acs.jnatprod.9b00073

11907 Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Dis. Markers 2019 PubMed ID: 31019584 DOI: 10.1155/2019/8040361

11931 Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs. Anticancer Res. 2019 PubMed ID: 31810932 DOI: 10.21873/anticanres.13882

11933 Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones. Anticancer Res. 2019 PubMed ID: 31810912 DOI: 10.21873/anticanres.13862

12457 Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. SYT12 plays a critical role in oral cancer and may be a novel therapeutic target J Cancer 2019 10(20):4913-4920 PubMed ID: 31598163 DOI: 10.7150/jca.32582

12586 Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner J Clin Biochem Nutr 2019 65(1):8-15 PubMed ID: 31379408 DOI: 10.3164/jcbn.18-91

10682 Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. Biochem. Biophys. Res. Commun. 2018 495:2469-2474 PubMed ID: 29278705 DOI: 10.1016/j.bbrc.2017.12.138

10683 Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H. Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma. Biochem. Biophys. Res. Commun. 2018 495:2303-2309 PubMed ID: 29278708 DOI: 10.1016/j.bbrc.2017.12.136

10724 Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters. Anticancer Res. 2018 38:817-823 PubMed ID: 29374707 DOI: 10.21873/anticanres.12289

10727 Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones. Anticancer Res. 2018 38:763-770 PubMed ID: 29374700 DOI: 10.21873/anticanres.12282

10806 Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp. Cell Res. 2018 367:112-118 PubMed ID: 29614312 DOI: 10.1016/j.yexcr.2018.03.041

10820 Fukamachi M, Kasamatsu A, Endo-Sakamoto Y, Fushimi K, Kasama H, Iyoda M, Minakawa Y, Shiiba M, Tanzawa H, Uzawa K. Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer. Exp. Cell Res. 2018 368:119-125 PubMed ID: 29679592 DOI: 10.1016/j.yexcr.2018.04.021

10829 Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H. In Vitro Anti-tumor Activity of Azulene Amide Derivatives. In Vivo 2018 32:479-486 PubMed ID: 29695549 DOI: 10.21873/invivo.11264

11086 Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones. Anticancer Res. 2018 38(6):3283-3290 PubMed ID: 29848675 DOI: 10.21873/anticanres.12593

11147 Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones. Anticancer Res. 2018 38(8):4449-4457 PubMed ID: 30061209 DOI: 10.21873/anticanres.12747

11148 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(8):4459-4467 PubMed ID: 30061210 DOI: 10.21873/anticanres.12748

11226 Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer 2018 PubMed ID: 30271493 DOI: 10.7150/jca.25666

4078 Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates Medicinal Chemistry Research 2018 27:2366–2378 DOI: 10.1007/s00044-018-2242-5

4172 Tamai R, Kobayashi-Sakamoto M, Kiyoura Y. Extracellular galectin-1 enhances adhesion to and invasion of oral epithelial cells by Porphyromonas gingivalis. Can. J. Microbiol. 2018 PubMed ID: 29544077 DOI: 10.1139/cjm-2017-0461

4173 Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H. In Vitro Antitumor Activity of Alkylaminoguaiazulenes. In Vivo 2018 PubMed ID: 29695558 DOI: 10.21873/invivo.11273

4236 Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncol. Rep. 2018 PubMed ID: 29192320 DOI: 10.3892/or.2017.6105

4237 Yamanouchi R, Harada K, Ferdous T, Ueyama Y. Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Mol Clin Oncol 2018 PubMed ID: 29456845 DOI: 10.3892/mco.2018.1548

4345 Hou B, Ishinaga H, Midorikawa K, Nakamura S, Hiraku Y, Oikawa S, Ma N, Takeuchi K, Murata M. Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2. Oncotarget 2018 PubMed ID: 29507664 DOI: 10.18632/oncotarget.23826

16201 Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K. Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer Lab Invest 2018 98(8):980-988 PubMed ID: 29855544 DOI: 10.1038/s41374-018-0070-3

16207 Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato , Susumu Nakata, Yasushi Yatabe, Mitsuo Goto, Norio Kaneda , Kenichi Kurita, Hayao Nakanishi, Kenji Yoshida A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green-Labeled Podoplanin Antibody Technol Cancer Res Treat 2018 1533033818767936. PubMed ID: 29649929 DOI: 10.1177/1533033818767936

9835 Evans M, Murofushi T, Tsuda H, Mikami Y, Zhao N, Ochiai K, Kurita-Ochiai T, Yamamoto M, Otsuka K, Suzuki N. Combined effects of starvation and butyrate on autophagy-dependent gingival epithelial cell death. J. Periodont. Res. 2017 52:522-531 PubMed ID: 27624546 DOI: 10.1111/jre.12418

9915 Tsubaki M, Fujiwara D, Takeda T, Kino T, Tomonari Y, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S. The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways. Clin. Exp. Pharmacol. Physiol. 2017 44:222-234 PubMed ID: 27805296 DOI: 10.1111/1440-1681.12690

9962 Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F. Comparative analysis of motility and other properties of Treponema denticola strains. Microb. Pathog. 2017 102:82-88 PubMed ID: 27914958 DOI: 10.1016/j.micpath.2016.11.021

10148 Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Exp. Cell Res. 2017 352:357-363 PubMed ID: 28237246 DOI: 10.1016/j.yexcr.2017.02.026

10155 Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer. Sci Rep 2017 7:43379 PubMed ID: 28230172 DOI: 10.1038/srep43379

10191 Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem. Biophys. Res. Commun. 2017 486:385-390 PubMed ID: 28315328 DOI: 10.1016/j.bbrc.2017.03.050

10197 Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T. Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin. Anticancer Res. 2017 37:1023-1029 PubMed ID: 28314260 DOI: 10.21873/anticanres.11412

10201 Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Chalcones. Anticancer Res. 2017 37:1091-1098 PubMed ID: 28314269 DOI: 10.21873/anticanres.11421

10206 Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T. Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas. Molecules 2017 22: PubMed ID: 28294988 DOI: 10.3390/molecules22030470

10241 Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M. A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem. Pharm. Bull. 2017 65:365-372 PubMed ID: 28381677 DOI: 10.1248/cpb.c16-00830

10344 Takada A, Matsushita K, Horioka S, Furuichi Y, Sumi Y. Bactericidal effects of 310 nm ultraviolet light-emitting diode irradiation on oral bacteria. BMC Oral Health 2017 17:96 PubMed ID: 28587675 DOI: 10.1186/s12903-017-0382-5

10377 Takamura T, Suguro H, Mikami Y, Iwase T, Komiyama Y, Kuyama K, Komiyama K, Oki H. Comparison of gene expression profiles of gingival carcinoma Ca9-22 cells and colorectal adenocarcinoma HT-29 cells to identify potentially important mediators of SLPI-induced cell migration. J Oral Sci 2017 59:279-287 PubMed ID: 28637988 DOI: 10.2334/josnusd.16-0534

10386 Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y. Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices. In Vivo 2017 31:591-598 PubMed ID: 28652425 DOI: 10.21873/invivo.11099

10418 Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis. J Cancer 2017 8:2033-2041 PubMed ID: 28819404 DOI: 10.7150/jca.18714

10517 Murofushi T, Tsuda H, Mikami Y, Yamaguchi Y, Suzuki N. CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells. J Oral Sci 2017 59:415-423 PubMed ID: 28904318 DOI: 10.2334/josnusd.16-0696

10526 Ohno T, Yamamoto G, Hayashi JI, Nishida E, Goto H, Sasaki Y, Kikuchi T, Fukuda M, Hasegawa Y, Mogi M, Mitani A. Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells. PLoS ONE 2017 12:e0184825 PubMed ID: 28934245 DOI: 10.1371/journal.pone.0184825

10572 Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Aurones. Anticancer Res. 2017 37:6169-6176 PubMed ID: 29061798 DOI: 10.21873/anticanres.12066

10576 Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters. Anticancer Res. 2017 37:6161-6168 PubMed ID: 29061797 DOI: 10.21873/anticanres.12065

10937 Effect of Micro/Nano-Patterned Surfaces on Cell Adhesion of Ca9-22 cells e-J. Surf. Sci. Nanotech. 2017 15 : 1-6 DOI: 10.1380/ejssnt.2017.1

10958 Inactivation of dermatopontin via histone deacetylation in human oral cancer Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2017 29, 400-404 DOI: 10.1016/j.ajoms.2017.03.013

4574 Yasui H, Ohnishi Y, Nakajima M, Nozaki M. Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation. Oncol Rep 2017 37(6):3674-3680 PubMed ID: 28440510 DOI: 10.3892/or.2017.5587

6027 lNorihisa Ichimura et al Notch3 is frequently downregulated in oral cancer Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2017 29:504-510 DOI: 10.1016/j.ajoms.2017.06.006

6641 Mariko Kawai, Kiyoshi Ohura A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants Open Journal of Stomatology 2017 7:494-500 DOI: 10.4236/ojst.2017.711046

12679 Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K. Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Cancer Res 2017 77(9):2363-2374 PubMed ID: 28209617 DOI: 10.1158/0008-5472.CAN-16-2114

14613 Nagai K, Domon H, Oda M, Shirai T, Ohsumi T, Terao Y, Arai Y. Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria Dent Mater J 2017 36(6):784-790 PubMed ID: 28747597 DOI: 10.4012/dmj.2016-321

7139 Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y. Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans. Microbiol. Immunol. 2016 60:10-6 PubMed ID: 26600203 DOI: 10.1111/1348-0421.12343

7181 Gojoubori T, Ota H, Kusunoki M, Nishio Y, Nishio K, Iwasa S, Kaneko Y, Asano M. Electrolytically generated acid functional water inhibits NF-κB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits. J. Recept. Signal Transduct. Res. 2016 36:248-53 PubMed ID: 26480200 DOI: 10.3109/10799893.2015.1086883

9558 Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K. THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. J. Oral Pathol. Med. 2016 45:730-739 PubMed ID: 26850833 DOI: 10.1111/jop.12430

9584 Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H. Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline. In Vivo 2016 30:91-7 PubMed ID: 26912818

9604 Chang HS, Tang JY, Yen CY, Huang HW, Wu CY, Chung YA, Wang HR, Chen IS, Huang MY, Chang HW. Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. BMC Complement Altern Med 2016 16:94 PubMed ID: 26955958 DOI: 10.1186/s12906-016-1073-5

9616 Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer 2016 7:600-7 PubMed ID: 27053959 DOI: 10.7150/jca.13820

9630 Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma. J Cancer 2016 7:702-10 PubMed ID: 27076852 DOI: 10.7150/jca.14208

9702 Mikami Y, Fukushima A, Komiyama Y, Iwase T, Tsuda H, Higuchi Y, Hayakawa S, Kuyama K, Komiyama K. Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion. Cancer Lett. 2016 379:84-93 PubMed ID: 27238568 DOI: 10.1016/j.canlet.2016.05.028

9762 Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M. Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. PLoS ONE 2016 11:e0159693 PubMed ID: 27441818 DOI: 10.1371/journal.pone.0159693

9783 Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS ONE 2016 11:e0161163 PubMed ID: 27512993 DOI: 10.1371/journal.pone.0161163

9808 Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H. Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone. In Vivo 2016 30:645-50 PubMed ID: 27566085

9892 Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y. Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones. Anticancer Res. 2016 36:5803-5812 PubMed ID: 27793902 DOI: 10.21873/anticanres.11164

9911 Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H. Antiviral and Antitumor Activity of Licorice Root Extracts. In Vivo 2016 30:777-785 PubMed ID: 27815461 DOI: 10.21873/invivo.10994

6036 Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer. Int J Oncol. 2016 48(2):607-12 PubMed ID: 26718916 DOI: 10.3892/ijo.2015.3305

12609 Usui M, Sato T, Yamamoto G, Okamatsu Y, Hanatani T, Moritani Y, Sano K, Yamamoto M, Nakashima K. Gingival epithelial cells support osteoclastogenesis by producing receptor activator of nuclear factor kappa B ligand via protein kinase A signaling J Periodontal Res 2016 51(4):462-70 PubMed ID: 26432443 DOI: 10.1111/jre.12323

14581 Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, Kishi Y, Hamada Y, Masutani M. Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo Int J Mol Sci 2016 17(3):272 PubMed ID: 26927065 DOI: 10.3390/ijms17030272

7196 Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. Anticancer Res. 2015 35:5299-307 PubMed ID: 26408690

5422 Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5. Quantitative Structure-Cytotoxicity Relationship of Oleoylamides. Anticancer Res 2015 5(10):5341-51 PubMed ID: 26408695

6043 Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y. Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells. Toxicol Rep 2015 2:1281-1290 PubMed ID: 28962471 DOI: 10.1016/j.toxrep.2015.09.009

6044 Kasama H　et al Adenosine A2b receptor promotes progression of human oral cancer. BMC Cancer 2015 15:563 PubMed ID: 26228921 DOI: 10.1186/s12885-015-1577-2

6051 Okamoto A　et al Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma. PLoS One 2015 10(11):e0142252 PubMed ID: 26554377 DOI: 10.1371/journal.pone.0142252

6052 Saito T et al Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis. PLoS One 2015 10(9):e0137923 PubMed ID: 26378920 DOI: 10.1371/journal.pone.0137923

6053 Miyamoto I et al Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth. Biochem Biophys Rep 2015 3:26-31 PubMed ID: 29124166 DOI: 10.1016/j.bbrep.2015.07.008

6054 Baba T et al Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway. Mol Carcinog 2015 54(8):608-17 PubMed ID: 24375483 DOI: 10.1002/mc.22127

6058 Shida-Sakazume T et al Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. PLoS One. 2015 10(3):e0120143 PubMed ID: 25803864 DOI: 10.1371/journal.pone.0120143

15042 Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer Cancer Med 2015 4(5):759-69 PubMed ID: 25644496 DOI: 10.1002/cam4.418

10887 Goto H, Ishihara Y, Kikuchi T, Izawa A, Ozeki N, Okabe E, Kamiya Y, Ozawa Y, Mizutani H, Yamamoto G, Mogi M, Nakata K, Maeda H, Noguchi T, Mitani A. Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression PLoS One 2015 10(10):e0140942 PubMed ID: 26474296 DOI: 10.1371/journal.pone.0140942

6006 Ohnishi Y, Watanabe M, Yasui H, Kakudo K. Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines. Oncol Lett 2014 7(5):1439-1442 PubMed ID: 24765152 DOI: 10.3892/ol.2014.1946

5916 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells. In Vivo 2014 28(4):549-56 PubMed ID: 24982221

5807 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells. In Vivo 2014 28(5):895-907 PubMed ID: 25189906

5778 Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer. Mol Carcinog 2014 53(7):557-65 PubMed ID: 23371469 DOI: 10.1002/mc.22007

5659 Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of 3-styrylchromones. Anticancer Res 2014 34(10):5405-11 PubMed ID: 25275035

5544 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of phenylpropanoid amides. Anticancer Res 2014 34(7):3543-8 PubMed ID: 24982367

5337 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of piperic acid amides. Anticancer Res 2014 34(9):4877-84 PubMed ID: 25202069

5315 Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H. Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones. Anticancer Res 2014 4(4):1743-50 PubMed ID: 24692705

9145 Yuki Abiko, Keiji Nagano 1, Yasuo Yoshida 1, Fuminobu Yoshimura 1 Characterization of Treponema Denticola Mutants Defective in the Major Antigenic Proteins, Msp and TmpC PLoS One 2014 9 (11), e113565 PubMed ID: 25401769 DOI: 10.1371/journal.pone.0113565

10944 Yuki Abiko, Keiji Nagano, Yasuo Yoshida, Fuminobu Yoshimura Major Membrane Protein TDE2508 Regulates Adhesive Potency in Treponema Denticola PLoS One 2014 9(2):e89051 PubMed ID: 24586498 DOI: 10.1371/journal.pone.0089051

16005 Kato Y, Hagiwara M, Ishihara Y, Isoda R, Sugiura S, Komatsu T, Ishida N, Noguchi T, Matsushita K. TNF-α augmented Porphyromonas gingivalis invasion in human gingival epithelial cells through Rab5 and ICAM-1 BMC Microbiol 2014 14:229 PubMed ID: 25179218 DOI: 10.1186/s12866-014-0229-z

5028 Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol 2013 139(4):585-94 PubMed ID: 23242234 DOI: 10.1007/s00432-012-1361-5

6067 Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K. High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer. Int J Oncol 2013 42(1):141-50 PubMed ID: 23123766 DOI: 10.3892/ijo.2012.1677

6070 Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013 139(4):533-42 PubMed ID: 23207790 DOI: 10.1007/s00432-012-1356-2

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