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Cell No. : Cell Name
RCB1975 : HSC-3  update : 2022/05/12
CommentHuman tongue squamous cell carcinoma cell line. HLA-A 2/24. TKG0484 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Momose, F.
Year of deposit 2004
Original cell TKG0484
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 64 years
Tissue tongue
Disease name Squamous cell carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0484)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1288
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 3
User's Publication 179


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Reference
3303  Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S.  Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.  In Vitro Cell Dev Biol  1990  26:849-856  PubMed ID: 2228902  
3248  Ichijo H, Momose F, Miyazono K  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718   DOI: 10.1016/0014-4827(90)90090-w
3243  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303   DOI: 10.1111/j.1600-0714.1989.tb01570.x

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User's Publication
20382  Fan M, Arai M, Tawada A, Chiba T, Fukushima R, Uzawa K, Shiiba M, Kato N, Tanzawa H, Takiguchi Y.  Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers.  Oncol Rep  2022  47(1)  PubMed ID: 34738627   DOI: 10.3892/or.2021.8216
20513  Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y.  Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma.  Oncoimmunology  2022  11(1):2021619  PubMed ID: 35003900   DOI: 10.1080/2162402X.2021.2021619
20544  Matsuda R, Sakagami H, Amano S, Iijima Y, Sano M, Uesawa Y, Tamura N, Oishi Y, Takeshima H.  Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid.  Anticancer Res  2022  42(2):781-790  PubMed ID: 35093876   DOI: 10.21873/anticanres.15536
16180  Katsuhiro Asaka, Akira Fukatsu, Chiaki Komine  The Effectiveness of a Portable Fluorescence Spectrophotometer for Early Detection of Oral Cancer  Open Journal of Stomatology  2022  12:30-31    DOI: 10.4236/ojst.2022.121003
16203  Sasabe E, Tomomura A, Liu H, Sento S, Kitamura N, Yamamoto T.  Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis  Cancer Sci   2022  113(2):609-621  PubMed ID: 34874595   DOI: 10.1111/cas.15225
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748   DOI: 10.3390/ijms23052601
20815  Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR.  Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells.  Medicines (Basel)  2022  9(6)  PubMed ID: 35736248   DOI: 10.3390/medicines9060035
17100  Izumi A, Yamamoto K, Kawaguchi M, Yamashita F, Fukushima T, Kiwaki T, Tanaka H, Yamashita Y, Kataoka H.  Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells  Cancer Sci  2022  113(6):2179-2193  PubMed ID: 35332604   DOI: 10.1111/cas.15346
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20932  Katase N, Nishimatsu SI, Yamauchi A, Okano S, Fujita S.  Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC).  Cancer Cell Int  2022  22(1):352  PubMed ID: 36376957   DOI: 10.1186/s12935-022-02783-9
20085  Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H.  Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.  Sci Rep  2021  11(1):5897  PubMed ID: 33723306   DOI: 10.1038/s41598-021-85242-1
20133  Nakamura A, Kakihara Y, Funayama A, Haga K, Mikami T, Kobayashi D, Yoshida Y, Izumi K, Kobayashi T, Saeki M.  HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma.  Biochem Biophys Res Commun  2021  557:294-301  PubMed ID: 33894417   DOI: 10.1016/j.bbrc.2021.04.021
14869  Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K.  miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells  Sci Rep  2021  11(1):13502  PubMed ID: 34226586   DOI: 10.1038/s41598-021-92879-5
20350  Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI.  Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression.  Transl Oncol  2021  14(12):101236  PubMed ID: 34624685   DOI: 10.1016/j.tranon.2021.101236
20406  Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.  High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.  Heliyon  2021  7(11):e08318  PubMed ID: 34816032   DOI: 10.1016/j.heliyon.2021.e08318
20438  Yang KH, Tang JY, Chen YN, Chuang YT, Tsai IH, Chiu CC, Li LJ, Chien TM, Cheng YB, Chang FR, Yen CY, Chang HW.  Nepenthes Extract Induces Selective Killing, Necrosis, and Apoptosis in Oral Cancer Cells.  J Pers Med  2021  11(9)  PubMed ID: 34575651   DOI: 10.3390/jpm11090871
15868  Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K.  Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma  Oncol Lett  2021  22(4):730  PubMed ID: 34429770   DOI: 10.3892/ol.2021.12991
16099  Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E.  PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1  Int J Oncol  2021  58(6):29  PubMed ID: 33887877   DOI: 10.3892/ijo.2021.5209
16112  Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M.  Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells  Oral Surg Oral Med Oral Pathol Oral Radiol  2021  132(5):549-565  PubMed ID: 34518137   DOI: 10.1016/j.oooo.2021.04.006
16136  Harada K, Ferdous T, Watanabe K, Mizukami Y, Mishima K.  Effects of an elemental diet, Elental®, may differ between healthy oral cells and oral cancer cells  Oncol Rep  2021  45(2):738-751  PubMed ID: 33416174   DOI: 10.3892/or.2020.7896
16138  Ando T, Kasamatsu A, Kawasaki K, Hiroshima K, Fukushima R, Iyoda M, Nakashima D, Endo-Sakamoto Y, Uzawa K.  Tumor Suppressive Circular RNA-102450: Development of a Novel Diagnostic Procedure for Lymph Node Metastasis from Oral Cancer  Cancers (Basel)  2021  13(22):5708  PubMed ID: 34830863   DOI: 10.3390/cancers13225708
16139  Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma  Int J Mol Sci   2021  22(23):12684  PubMed ID: 34884487   DOI: 10.3390/ijms222312684
16173  Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S.  Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels  Nat Biomed Eng  2021  5(8):914-925  PubMed ID: 33782572   DOI: 10.1038/s41551-021-00692-2
16196  Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S.  Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue  Medicines (Basel)  2021  8(7):33  PubMed ID: 34206186   DOI: 10.3390/medicines8070033
16206  Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma  Int J Mol Sci  2021  22(18):9947  PubMed ID: 34576110   DOI: 10.3390/ijms22189947
16862  Kawasaki M, Sakabe T, Kodani I, Umekita Y.  Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma  Anticancer Res  2021  41(9):4563-4570  PubMed ID: 34475084   DOI: 10.21873/anticanres.15269
16975  Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K.  Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling  Anticancer Res  2021  41(4):1821-1830  PubMed ID: 33813387   DOI: 10.21873/anticanres.14948
11844  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Oral Dis  2020  26(4):745-755  PubMed ID: 31603606   DOI: 10.1111/odi.13210
11965  Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T.  The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.  Lab. Invest.  2020    PubMed ID: 31857698   DOI: 10.1038/s41374-019-0357-z
13013  Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H.  Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation.  In Vivo  2020    PubMed ID: 32354886   DOI: 10.21873/invivo.11869
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607   DOI: 10.21873/anticanres.14357
13148  Tang JY, Wu KH, Wang YY, Farooqi AA, Huang HW, Yuan SF, Jian RI, Tsao LY, Chen PA, Chang FR, Cheng YB, Hu HC, Chang HW.  Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress.  Antioxidants (Basel)  2020    PubMed ID: 32756347   DOI: 10.3390/antiox9080694
13205  Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H.  Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro.  Anticancer Res  2020    PubMed ID: 32878776   DOI: 10.21873/anticanres.14491
13401  Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H.  Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.  Oncoimmunology  2020    PubMed ID: 33457076   DOI: 10.1080/2162402X.2020.1856545
13783  Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O.  Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy  Cancer Sci  2020  111(1):127-136.  PubMed ID: 31692172   DOI: 10.1111/cas.14224
13892  Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H, Kayamori K, Yamaguchi A, Sakamoto K.  AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression  PLoS One  2020  15(2):e0222689  PubMed ID: 32012175   DOI: 10.1371/journal.pone.0222689
13903  Aika Tanzawa et al.  Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma  Oral Science International  2020  17(2):67-72    DOI: 10.1002/osi2.1044
13920  Kazutaka KIMURA, Yuichi OHNISHI, Tomoharu OKAMURA, Kazuya TOMINAGA, Masahiro NAKAJIMA  Effect of HGF/c-Met pathway in oral squamous cell carcinoma on EMT and metastatic potential  Journal of Osaka Dental University  2020  54(1):135-144    DOI: 10.18905/jodu.54.1_135
10691  Iwai S, Kishimoto S, Amano Y, Nishiguchi A, Matsusaki M, Takeshita A, Akashi M.  Three-dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion.  J Biomed Mater Res A  2019  107(2):292-300  PubMed ID: 29280265   DOI: 10.1002/jbm.a.36319
11300  Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.  Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma.  Int. J. Oncol.  2019    PubMed ID: 30431077   DOI: 10.3892/ijo.2018.4631
11350  Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Fujita S.  DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.  Int. J. Oncol.  2019    PubMed ID: 30569110   DOI: 10.3892/ijo.2018.4667
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341   DOI: 10.1016/j.bbrc.2018.12.066
6020  Matsuo K, Suzuki H, Yatagai N, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Matsumoto K, Komori T.  Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line.  Kobe J Med Sci  2019  64(6):E210-E216  PubMed ID: 31327864  
11584  Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW.  Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress.  Environ. Toxicol.  2019    PubMed ID: 31157515   DOI: 10.1002/tox.22748
11590  Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW.  Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells.  DNA Cell Biol.  2019    PubMed ID: 31170002   DOI: 10.1089/dna.2018.4436
11620  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Anticancer Res.  2019    PubMed ID: 31262875   DOI: 10.21873/anticanres.13497
11759  Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H.  Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma.  Sci Rep  2019    PubMed ID: 31434965   DOI: 10.1038/s41598-019-48717-w
9696  Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa  Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma  Exp Cell Res  2019  384(2):111622  PubMed ID: 31518558   DOI: 10.1016/j.yexcr.2019.111622
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
9890  Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa  Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement  J Cancer  2019  10(16):3728-3734  PubMed ID: 31333790   DOI: 10.7150/jca.32281
11907  Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M.  Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review.  Dis. Markers  2019    PubMed ID: 31019584   DOI: 10.1155/2019/8040361
11931  Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs.  Anticancer Res.  2019    PubMed ID: 31810932   DOI: 10.21873/anticanres.13882
11933  Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones.  Anticancer Res.  2019    PubMed ID: 31810912   DOI: 10.21873/anticanres.13862
12457  Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  SYT12 plays a critical role in oral cancer and may be a novel therapeutic target  J Cancer  2019  10(20):4913-4920  PubMed ID: 31598163   DOI: 10.7150/jca.32582
12459  Krishnan NM, Katoh H, Palve V, Pareek M, Sato R, Ishikawa S, Panda B.  Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma  PeerJ  2019  7:e6464  PubMed ID: 30842898   DOI: 10.7717/peerj.6464
12460  Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H.  LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer  Oncotarget  2019  10(10):1014-1030  PubMed ID: 30800215   DOI: 10.18632/oncotarget.26583
12586  Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S.  Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner  J Clin Biochem Nutr  2019  65(1):8-15  PubMed ID: 31379408   DOI: 10.3164/jcbn.18-91
10649  Koshizuka K, Hanazawa T, Kikkawa N, Katada K, Okato A, Arai T, Idichi T, Osako Y, Okamoto Y, Seki N.  Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma.  Auris Nasus Larynx  2018  45:854-865  PubMed ID: 29233721   DOI: 10.1016/j.anl.2017.11.019
10664  Ohnishi Y, Yasui H, Nozaki M, Nakajima M.  Molecularly-targeted therapy for the oral cancer stem cells.  Jpn Dent Sci Rev  2018  54:88-103  PubMed ID: 29755619   DOI: 10.1016/j.jdsr.2017.11.001
10668  Ikehata N, Takanashi M, Satomi T, Watanabe M, Hasegawa O, Kono M, Enomoto A, Chikazu D, Kuroda M.  Toll-like receptor 2 activation implicated in oral squamous cell carcinoma development.  Biochem. Biophys. Res. Commun.  2018  495:2227-2234  PubMed ID: 29269299   DOI: 10.1016/j.bbrc.2017.12.098
10724  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707   DOI: 10.21873/anticanres.12289
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312   DOI: 10.1016/j.yexcr.2018.03.041
10829  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  In Vivo  2018  32:479-486  PubMed ID: 29695549   DOI: 10.21873/invivo.11264
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454   DOI: 10.21873/invivo.11303
11115  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(7):3897-3906  PubMed ID: 29970510   DOI: 10.21873/anticanres.12674
11148  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210   DOI: 10.21873/anticanres.12748
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493   DOI: 10.7150/jca.25666
11306  Kakuguchi W, Nomura T, Kitamura T, Otsuguro S, Matsushita K, Sakaitani M, Maenaka K, Tei K.  Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells.  Cancer Med  2018    PubMed ID: 30449075   DOI: 10.1002/cam4.1877
4173  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  In Vivo  2018    PubMed ID: 29695558   DOI: 10.21873/invivo.11273
4235  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Oncotarget  2018    PubMed ID: 30333913   DOI: 10.18632/oncotarget.26112
4236  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Oncol. Rep.  2018    PubMed ID: 29192320   DOI: 10.3892/or.2017.6105
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845   DOI: 10.3892/mco.2018.1548
4238  Sumi S, Umemura N, Adachi M, Ohta T, Naganawa K, Kawaki H, Takayama E, Kondoh N, Sumitomo S.  The luminance ratio of autofluorescence in a xenograft mouse model is stable through tumor growth stages.  Clin Exp Dent Res  2018    PubMed ID: 30386639   DOI: 10.1002/cre2.126
4239  Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D.  Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma.  Int. J. Oncol.  2018    PubMed ID: 29344674   DOI: 10.3892/ijo.2018.4247
4240  Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M.  DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.  Arch. Oral Biol.  2018    PubMed ID: 29522917   DOI: 10.1016/j.archoralbio.2018.02.016
4241  Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI.  Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.  Oncol. Rep.  2018    PubMed ID: 30132562   DOI: 10.3892/or.2018.6665
4242  Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.  Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.  Int. J. Oncol.  2018    PubMed ID: 29115586   DOI: 10.3892/ijo.2017.4181
14824  Chung MK, Jung YH, Lee JK, Cho SY, Murillo-Sauca O, Uppaluri R, Shin JH, Sunwoo JB.  CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug  Clin Cancer Res  2018  24(3):674-683  PubMed ID: 29208672   DOI: 10.1158/1078-0432.CCR-17-0866
14677  Yamamoto K, Kawaguchi M, Shimomura T, Izumi A, Konari K, Honda A, Lin CY, Johnson MD, Yamashita Y, Fukushima T, Kataoka H.  Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/ SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells  Oncotarget  2018  9(14):11691-11706.  PubMed ID: 29545930   DOI: 10.18632/oncotarget.24450
16201  Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K.  Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer  Lab Invest  2018  98(8):980-988  PubMed ID: 29855544   DOI: 10.1038/s41374-018-0070-3
16207  Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato , Susumu Nakata, Yasushi Yatabe, Mitsuo Goto, Norio Kaneda , Kenichi Kurita, Hayao Nakanishi, Kenji Yoshida  A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green-Labeled Podoplanin Antibody  Technol Cancer Res Treat  2018  1533033818767936.  PubMed ID: 29649929   DOI: 10.1177/1533033818767936
10044  Ohkoshi E, Umemura N.  Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells.  Int. J. Oncol.  2017  50:387-395  PubMed ID: 28035370   DOI: 10.3892/ijo.2016.3821
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246   DOI: 10.1016/j.yexcr.2017.02.026
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328   DOI: 10.1016/j.bbrc.2017.03.050
10197  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260   DOI: 10.21873/anticanres.11412
10201  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269   DOI: 10.21873/anticanres.11421
10206  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Molecules  2017  22:  PubMed ID: 28294988   DOI: 10.3390/molecules22030470
10241  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677   DOI: 10.1248/cpb.c16-00830
10386  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  In Vivo  2017  31:591-598  PubMed ID: 28652425   DOI: 10.21873/invivo.11099
10576  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797   DOI: 10.21873/anticanres.12065
11036    Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation  Int J Cancer Oncol  2017  4: 225- 230    DOI: 10.15436/2377-0902.17.1628
6024  Hamada M, Kameyama H, Iwai S, Yura Y.  Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.  Cell Death Discov  2017  3:17047  PubMed ID: 29109864   DOI: 10.1038/cddiscovery.2017.47
14254  Koshizuka K, Nohata N, Hanazawa T, Kikkawa N, Arai T, Okato A, Fukumoto I, Katada K, Okamoto Y, Seki N.  Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs  Oncotarget  2017  8(18):30288-30304  PubMed ID: 28415821   DOI: 10.18632/oncotarget.16327
14365  Koshizuka K, Hanazawa T, Kikkawa N, Arai T, Okato A, Kurozumi A, Kato M, Katada K, Okamoto Y, Seki N.  Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer  Cancer Sci  2017  108(8):1681-1692  PubMed ID: 28612520   DOI: 10.1111/cas.13298
7096  Yoshino F, Yoshida A, Toyama T, Wada-T S, Takahashi S  α-Glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch.  J Functional Foods  2016  21:223-231    DOI: 10.1016/j.jff.2015.12.008
9584  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  In Vivo  2016  30:91-7  PubMed ID: 26912818  
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959   DOI: 10.7150/jca.13820
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852   DOI: 10.7150/jca.14208
9654  Kumasaka A, Matsumoto N, Mukae S, Kitano T, Noguchi H, Ohki H, Komiyama K, Ando T.  Rapid and Specific Screening Assay for KRAS Oncogene Mutation by a Novel Gene Amplification Method.  Anticancer Res.  2016  36:1571-9  PubMed ID: 27069133  
9676  Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A.  Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.  Anticancer Res.  2016  36:2161-8  PubMed ID: 27127118  
9694  Harada K, Ferdous T, Harada T, Ueyama Y.  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058   DOI: 10.3892/ijo.2016.3523
9762  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818   DOI: 10.1371/journal.pone.0159693
9808  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  In Vivo  2016  30:645-50  PubMed ID: 27566085  
9851  Masui A, Hamada M, Kameyama H, Wakabayashi K, Takasu A, Imai T, Iwai S, Yura Y.  Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis.  PLoS ONE  2016  11:e0162786  PubMed ID: 27658240   DOI: 10.1371/journal.pone.0162786
9892  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902   DOI: 10.21873/anticanres.11164
9896  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918   DOI: 10.21873/anticanres.11180
9911  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  Antiviral and Antitumor Activity of Licorice Root Extracts.  In Vivo  2016  30:777-785  PubMed ID: 27815461   DOI: 10.21873/invivo.10994
6032  Tada H, Shimizu T, Nagaoka I, Takada H.  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607   DOI: 10.2220/biomedres.37.199
6033  Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R.  Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.  Int J Oncol  2016  48(4):1670-8  PubMed ID: 26893131   DOI: 10.3892/ijo.2016.3391
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916   DOI: 10.3892/ijo.2015.3305
6042  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332   DOI: 10.1002/mc.22347
14162  Yamali C, Gul HI, Sakagami H, Supuran CT.  Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases  J Enzyme Inhib Med Chem  2016  31(sup4):125-131  PubMed ID: 27594305   DOI: 10.1080/14756366.2016.1221825
14178  Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T.  Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra  J Nat Prod  2016  79(4):984-95  PubMed ID: 26938659   DOI: 10.1021/acs.jnatprod.5b01065
7109  Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K.  Telomerase activity in the occurrence and progression of oral squamous cell carcinoma.  J Oral Sci  2015  57:295-303  PubMed ID: 26666852   DOI: 10.2334/josnusd.57.295
7175  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway.  Int. J. Oncol.  2015  47:2165-72  PubMed ID: 26497980   DOI: 10.3892/ijo.2015.3215
7196  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690  
5422  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695  
6043  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471   DOI: 10.1016/j.toxrep.2015.09.009
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921   DOI: 10.1186/s12885-015-1577-2
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377   DOI: 10.1371/journal.pone.0142252
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920   DOI: 10.1371/journal.pone.0137923
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166   DOI: 10.1016/j.bbrep.2015.07.008
6058  Shida-Sakazume T et al  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864   DOI: 10.1371/journal.pone.0120143
15042  Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer  Cancer Med  2015  4(5):759-69  PubMed ID: 25644496   DOI: 10.1002/cam4.418
6023  Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M.  NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma.  Oncol Lett  2014  7(1):35-40  PubMed ID: 24348816   DOI: 10.3892/ol.2013.1690
6006  Ohnishi Y, Watanabe M, Yasui H, Kakudo K.  Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines.  Oncol Lett  2014  7(5):1439-1442  PubMed ID: 24765152   DOI: 10.3892/ol.2014.1946
5916  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  In Vivo  2014  28(4):549-56  PubMed ID: 24982221  
5859  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344   DOI: 10.2220/biomedres.35.381
5807  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906  
5778  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469   DOI: 10.1002/mc.22007
5659  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035  
5605  Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M.  Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.  PLoS One  2014  9(12):e114121  PubMed ID: 25437003   DOI: 10.1371/journal.pone.0114121
5544  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367  
5337  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069  
5315  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705  
5307  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.  J Transl Med  2014  12:265  PubMed ID: 25240937   DOI: 10.1186/s12967-014-0265-3
5122  Iida S, Shimada J, Sakagami H.  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687  
5110  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061  
5057  Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y.  Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.  Int J Cancer.  2013  132(12):2755-66  PubMed ID: 23180648   DOI: 10.1002/ijc.27966
6070  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790   DOI: 10.1007/s00432-012-1356-2
6071  Kondoh M, Ohga N, Akiyama K, Hida Y, Maishi N, Towfik AM, Inoue N, Shindoh M, Hida K.  Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment.  PLoS One  2013  8(11):e80349  PubMed ID: 24260373   DOI: 10.1371/journal.pone.0080349
6072  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564   DOI: 10.1371/journal.pone.0056381
6076  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490   DOI: 10.1371/journal.pone.0085951
6077  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247   DOI: 10.1111/j.1600-0714.2012.01182.x
6078  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548   DOI: 10.1007/s10719-012-9458-2
6081  Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.  BMC Cancer  2013  13:555  PubMed ID: 24261884   DOI: 10.1186/1471-2407-13-555
6083  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 24045666   DOI: 10.1038/bjc.2013.577
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
7722  Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K.  Comprehensive epigenetic analysis using oral rinse samples: a pilot study.  J. Oral Maxillofac. Surg.  2012  70:1486-94  PubMed ID: 21821326   DOI: 10.1016/j.joms.2011.04.021
6087  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889   DOI: 10.2334/josnusd.54.71
6088  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311   DOI: 10.1002/path.3993
6089  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  J Oral Sci  2012  54(3):241-50  PubMed ID: 23047035   DOI: 10.2334/josnusd.54.241
6095  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894   DOI: 10.3892/ol.2011.473
6098  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Tumour Biol  2012  33(1):183-94  PubMed ID: 22081310   DOI: 10.1007/s13277-011-0261-7
15671  Harada T, Harada K, Ueyama Y.  The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma  Int J Oncol  2012  41(2):565-72  PubMed ID: 22664937   DOI: 10.3892/ijo.2012.1501
7601  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286  
7691  Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H.  Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma.  Cancer Sci.  2011  102:2164-71  PubMed ID: 21899661   DOI: 10.1111/j.1349-7006.2011.02096.x
6109  Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M.  A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions.  Int J Oncol  2011  39(6):1401-5  PubMed ID: 21785818   DOI: 10.3892/ijo.2011.1137
6112  lHiroshi Inoue et al  Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines  Asian Journal of Oral and Maxillofacial Surgery   2011  23:1-6    DOI: 10.1016/j.ajoms.2010.10.001
6116  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983   DOI: 10.3892/or.2010.1130
6118  Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo  Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer  Journal of Osaka Dental University  2011  45:31-36    DOI: 10.18905/jodu.45.1_31
8085  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  In Vivo  2010  24:735-43  PubMed ID: 20952742  
8383  Uemura N, Kodama S, Nomi N, Okamoto T, Suzuki M.  Correlation between anti-survivin antibody and survivin mRNA expression in head and neck cancer patients.  Acta Otolaryngol.  2010  130:959-65  PubMed ID: 20100132   DOI: 10.3109/00016480903555416
5611  Wakabayashi H, Narita T, Suga A, Sakagami H.  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973  
6120  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673   DOI: 10.1016/j.bbrc.2009.12.156
6122  Nomi N, Kodama S, Suzuki M.  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466   DOI: 10.3892/or_00000850
6123  Yuji Miyazaki et al  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  J Cancer Sci Ther  2010  2(2) :26-32   
13818  Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura  Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene  Journal of Electromagnetic Analysis and Applications  2010  2:382-394    DOI: 10.4236/jemaa.2010.26050
6127  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319  
6128  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186  
6129  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354  
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
6136  Okamura M, Shimada J, Sakagami H.  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853  
6138  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Anticancer Res  2008  28(2A):1069-78  PubMed ID: 18507056  
6141  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558   DOI: 10.1111/j.1349-7006.2008.00838.x
6143  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225  
6148  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125  
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456   DOI: 10.1038/sj.onc.1209158
6152  Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H.  Cytotoxic activity of azulenequinones against human oral tumor cell lines.  Anticancer Res  2005  25(1A):305-12  PubMed ID: 15816552  



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