CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1975 : HSC-3]

3303 Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S. Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium. In Vitro Cell Dev Biol 1990 26:849-856 PubMed ID: 2228902

3248 Ichijo H, Momose F, Miyazono K Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells. Exp Cell Res 1990 187:263-9 PubMed ID: 2156718

3243 Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas. J Oral Pathol Med 1989 18:391-5 PubMed ID: 2585303

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20085 Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H. Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Sci Rep 2021 11(1):5897 PubMed ID: 33723306

11965 Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T. The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. Lab. Invest. 2020 PubMed ID: 31857698

13013 Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H. Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation. In Vivo 2020 PubMed ID: 32354886

13148 Tang JY, Wu KH, Wang YY, Farooqi AA, Huang HW, Yuan SF, Jian RI, Tsao LY, Chen PA, Chang FR, Cheng YB, Hu HC, Chang HW. Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress. Antioxidants (Basel) 2020 PubMed ID: 32756347

13205 Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H. Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro. Anticancer Res 2020 PubMed ID: 32878776

13401 Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. Oncoimmunology 2020 PubMed ID: 33457076

13783 Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy Cancer Sci 2020 111(1):127-136. PubMed ID: 31692172

13892 Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H, Kayamori K, Yamaguchi A, Sakamoto K. AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression PLoS One 2020 15(2):e0222689 PubMed ID: 32012175

10691 Iwai S, Kishimoto S, Amano Y, Nishiguchi A, Matsusaki M, Takeshita A, Akashi M. Three-dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion. J Biomed Mater Res A 2019 107(2):292-300 PubMed ID: 29280265

11300 Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A. Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma. Int. J. Oncol. 2019 PubMed ID: 30431077

11350 Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Fujita S. DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways. Int. J. Oncol. 2019 PubMed ID: 30569110

11354 Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K. Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30587341

6020 Matsuo K, Suzuki H, Yatagai N, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Matsumoto K, Komori T. Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line. Kobe J Med Sci 2019 64(6):E210-E216 PubMed ID: 31327864

11584 Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW. Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress. Environ. Toxicol. 2019 PubMed ID: 31157515

11590 Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW. Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells. DNA Cell Biol. 2019 PubMed ID: 31170002

11620 Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H. Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives. Anticancer Res. 2019 PubMed ID: 31262875

11759 Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H. Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma. Sci Rep 2019 PubMed ID: 31434965

11844 Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M. CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity. Oral Dis 2019 PubMed ID: 31603606

9696 Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma Exp Cell Res 2019 384(2):111622 PubMed ID: 31518558

9890 Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement J Cancer 2019 10(16):3728-3734 PubMed ID: 31333790

11907 Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Dis. Markers 2019 PubMed ID: 31019584

11931 Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs. Anticancer Res. 2019 PubMed ID: 31810932

11933 Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones. Anticancer Res. 2019 PubMed ID: 31810912

12457 Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. SYT12 plays a critical role in oral cancer and may be a novel therapeutic target J Cancer 2019 10(20):4913-4920 PubMed ID: 31598163

12459 Krishnan NM, Katoh H, Palve V, Pareek M, Sato R, Ishikawa S, Panda B. Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma PeerJ 2019 7:e6464 PubMed ID: 30842898

12460 Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H. LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer Oncotarget 2019 10(10):1014-1030 PubMed ID: 30800215

12586 Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner J Clin Biochem Nutr 2019 65(1):8-15 PubMed ID: 31379408

10649 Koshizuka K, Hanazawa T, Kikkawa N, Katada K, Okato A, Arai T, Idichi T, Osako Y, Okamoto Y, Seki N. Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma. Auris Nasus Larynx 2018 45:854-865 PubMed ID: 29233721

10664 Ohnishi Y, Yasui H, Nozaki M, Nakajima M. Molecularly-targeted therapy for the oral cancer stem cells. Jpn Dent Sci Rev 2018 54:88-103 PubMed ID: 29755619

10668 Ikehata N, Takanashi M, Satomi T, Watanabe M, Hasegawa O, Kono M, Enomoto A, Chikazu D, Kuroda M. Toll-like receptor 2 activation implicated in oral squamous cell carcinoma development. Biochem. Biophys. Res. Commun. 2018 495:2227-2234 PubMed ID: 29269299

10724 Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters. Anticancer Res. 2018 38:817-823 PubMed ID: 29374707

10806 Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp. Cell Res. 2018 367:112-118 PubMed ID: 29614312

10829 Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H. In Vitro Anti-tumor Activity of Azulene Amide Derivatives. In Vivo 2018 32:479-486 PubMed ID: 29695549

11110 Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants. In Vivo 2018 32(4):745-752 PubMed ID: 29936454

11115 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(7):3897-3906 PubMed ID: 29970510

11148 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(8):4459-4467 PubMed ID: 30061210

11226 Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer 2018 PubMed ID: 30271493

11306 Kakuguchi W, Nomura T, Kitamura T, Otsuguro S, Matsushita K, Sakaitani M, Maenaka K, Tei K. Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells. Cancer Med 2018 PubMed ID: 30449075

4173 Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H. In Vitro Antitumor Activity of Alkylaminoguaiazulenes. In Vivo 2018 PubMed ID: 29695558

4235 Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget 2018 PubMed ID: 30333913

4236 Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncol. Rep. 2018 PubMed ID: 29192320

4237 Yamanouchi R, Harada K, Ferdous T, Ueyama Y. Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Mol Clin Oncol 2018 PubMed ID: 29456845

4238 Sumi S, Umemura N, Adachi M, Ohta T, Naganawa K, Kawaki H, Takayama E, Kondoh N, Sumitomo S. The luminance ratio of autofluorescence in a xenograft mouse model is stable through tumor growth stages. Clin Exp Dent Res 2018 PubMed ID: 30386639

4239 Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D. Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma. Int. J. Oncol. 2018 PubMed ID: 29344674

4240 Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M. DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4. Arch. Oral Biol. 2018 PubMed ID: 29522917

4241 Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI. Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma. Oncol. Rep. 2018 PubMed ID: 30132562

4242 Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y. Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. Int. J. Oncol. 2018 PubMed ID: 29115586

10044 Ohkoshi E, Umemura N. Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells. Int. J. Oncol. 2017 50:387-395 PubMed ID: 28035370

10148 Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Exp. Cell Res. 2017 352:357-363 PubMed ID: 28237246

10191 Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem. Biophys. Res. Commun. 2017 486:385-390 PubMed ID: 28315328

10197 Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T. Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin. Anticancer Res. 2017 37:1023-1029 PubMed ID: 28314260

10201 Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Chalcones. Anticancer Res. 2017 37:1091-1098 PubMed ID: 28314269

10206 Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T. Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas. Molecules 2017 22: PubMed ID: 28294988

10241 Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M. A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem. Pharm. Bull. 2017 65:365-372 PubMed ID: 28381677

10386 Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y. Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices. In Vivo 2017 31:591-598 PubMed ID: 28652425

10576 Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters. Anticancer Res. 2017 37:6161-6168 PubMed ID: 29061797

11036 Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation Int J Cancer Oncol 2017 4: 225- 230

6024 Hamada M, Kameyama H, Iwai S, Yura Y. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov 2017 3:17047 PubMed ID: 29109864

7096 Yoshino F, Yoshida A, Toyama T, Wada-T S, Takahashi S α-Glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch. J Functional Foods 2016 21:223-231

9584 Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H. Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline. In Vivo 2016 30:91-7 PubMed ID: 26912818

9616 Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer 2016 7:600-7 PubMed ID: 27053959

9630 Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma. J Cancer 2016 7:702-10 PubMed ID: 27076852

9654 Kumasaka A, Matsumoto N, Mukae S, Kitano T, Noguchi H, Ohki H, Komiyama K, Ando T. Rapid and Specific Screening Assay for KRAS Oncogene Mutation by a Novel Gene Amplification Method. Anticancer Res. 2016 36:1571-9 PubMed ID: 27069133

9676 Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A. Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production. Anticancer Res. 2016 36:2161-8 PubMed ID: 27127118

9694 Harada K, Ferdous T, Harada T, Ueyama Y. Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. Int. J. Oncol. 2016 49:276-84 PubMed ID: 27210058

9762 Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M. Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. PLoS ONE 2016 11:e0159693 PubMed ID: 27441818

9808 Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H. Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone. In Vivo 2016 30:645-50 PubMed ID: 27566085

9851 Masui A, Hamada M, Kameyama H, Wakabayashi K, Takasu A, Imai T, Iwai S, Yura Y. Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis. PLoS ONE 2016 11:e0162786 PubMed ID: 27658240

9892 Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y. Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones. Anticancer Res. 2016 36:5803-5812 PubMed ID: 27793902

9896 Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y. Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata. Anticancer Res. 2016 36:5931-5935 PubMed ID: 27793918

9911 Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H. Antiviral and Antitumor Activity of Licorice Root Extracts. In Vivo 2016 30:777-785 PubMed ID: 27815461

6032 Tada H, Shimizu T, Nagaoka I, Takada H. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res 2016 37(3):199-205 PubMed ID: 27356607

6033 Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R. Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. Int J Oncol 2016 48(4):1670-8 PubMed ID: 26893131

6036 Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer. Int J Oncol. 2016 48(2):607-12 PubMed ID: 26718916

6042 Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa Cavin-2 in oral cancer: A potential predictor for tumor progression. Mol Carcinog 2016 55(6):1037-47 PubMed ID: 26086332

7109 Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K. Telomerase activity in the occurrence and progression of oral squamous cell carcinoma. J Oral Sci 2015 57:295-303 PubMed ID: 26666852

7175 Ohnishi Y, Yasui H, Kakudo K, Nozaki M. Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway. Int. J. Oncol. 2015 47:2165-72 PubMed ID: 26497980

7196 Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. Anticancer Res. 2015 35:5299-307 PubMed ID: 26408690

5422 Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5. Quantitative Structure-Cytotoxicity Relationship of Oleoylamides. Anticancer Res 2015 5(10):5341-51 PubMed ID: 26408695

6043 Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y. Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells. Toxicol Rep 2015 2:1281-1290 PubMed ID: 28962471

6044 Kasama H　et al Adenosine A2b receptor promotes progression of human oral cancer. BMC Cancer 2015 15:563 PubMed ID: 26228921

6051 Okamoto A　et al Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma. PLoS One 2015 10(11):e0142252 PubMed ID: 26554377

6052 Saito T et al Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis. PLoS One 2015 10(9):e0137923 PubMed ID: 26378920

6053 Miyamoto I et al Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth. Biochem Biophys Rep 2015 3:26-31 PubMed ID: 29124166

6058 Shida-Sakazume T et al Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. PLoS One. 2015 10(3):e0120143 PubMed ID: 25803864

6023 Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M. NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma. Oncol Lett 2014 7(1):35-40 PubMed ID: 24348816

6006 Ohnishi Y, Watanabe M, Yasui H, Kakudo K. Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines. Oncol Lett 2014 7(5):1439-1442 PubMed ID: 24765152

5916 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells. In Vivo 2014 28(4):549-56 PubMed ID: 24982221

5859 Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC. Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma. Biomed Res. 2014 35(6):381-8 PubMed ID: 25743344

5807 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells. In Vivo 2014 28(5):895-907 PubMed ID: 25189906

5778 Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer. Mol Carcinog 2014 53(7):557-65 PubMed ID: 23371469

5659 Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of 3-styrylchromones. Anticancer Res 2014 34(10):5405-11 PubMed ID: 25275035

5605 Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M. Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing. PLoS One 2014 9(12):e114121 PubMed ID: 25437003

5544 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of phenylpropanoid amides. Anticancer Res 2014 34(7):3543-8 PubMed ID: 24982367

5337 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of piperic acid amides. Anticancer Res 2014 34(9):4877-84 PubMed ID: 25202069

5315 Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H. Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones. Anticancer Res 2014 4(4):1743-50 PubMed ID: 24692705

5307 Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor. J Transl Med 2014 12:265 PubMed ID: 25240937

5122 Iida S, Shimada J, Sakagami H. Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines. In Vivo 2013 27(3):321-32 PubMed ID: 23606687

5110 Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res 2013 33(8):3061-8 PubMed ID: 23898061

5057 Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y. Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma. Int J Cancer. 2013 132(12):2755-66 PubMed ID: 23180648

6070 Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013 139(4):533-42 PubMed ID: 23207790

6071 Kondoh M, Ohga N, Akiyama K, Hida Y, Maishi N, Towfik AM, Inoue N, Shindoh M, Hida K. Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment. PLoS One 2013 8(11):e80349 PubMed ID: 24260373

6072 Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One 2013 8(2):e56381 PubMed ID: 23418564

6076 Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Kinesin family member 4A: a potential predictor for progression of human oral cancer. PLoS One. 2 2013 8(12):e85951 PubMed ID: 24386490

6077 Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma. J Oral Pathol Med 2013 42(2):133-9 PubMed ID: 22672247

6078 Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K. Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J 2013 30(6):585-97 PubMed ID: 23242548

6081 Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation. BMC Cancer 2013 13:555 PubMed ID: 24261884

6083 Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy. Br J Cancer 2013 109(8):2155-66 PubMed ID: 24045666

7722 Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K. Comprehensive epigenetic analysis using oral rinse samples: a pilot study. J. Oral Maxillofac. Surg. 2012 70:1486-94 PubMed ID: 21821326

6087 Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K. Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines. J Oral Sci 2012 54(1):71-5 PubMed ID: 22466889

6088 Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H. Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness. J Pathol 2012 228(2):181-92 PubMed ID: 22262311

6089 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines. J Oral Sci 2012 54(3):241-50 PubMed ID: 23047035

6095 Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H. Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma. Oncol Lett 2012 3(2):273-280 PubMed ID: 22740894

6098 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity. Tumour Biol 2012 33(1):183-94 PubMed ID: 22081310

7601 Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H. Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives. Anticancer Res. 2011 31:4231-8 PubMed ID: 22199286

7691 Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H. Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma. Cancer Sci. 2011 102:2164-71 PubMed ID: 21899661

6109 Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M. A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. Int J Oncol 2011 39(6):1401-5 PubMed ID: 21785818

6112 lHiroshi Inoue et al Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines Asian Journal of Oral and Maxillofacial Surgery 2011 23:1-6

6116 Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H. Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells. Oncol Rep 2011 25(3):795-802 PubMed ID: 21206983

6118 Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer Journal of Osaka Dental University 2011 45：31-36

8085 Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. In Vivo 2010 24:735-43 PubMed ID: 20952742

8383 Uemura N, Kodama S, Nomi N, Okamoto T, Suzuki M. Correlation between anti-survivin antibody and survivin mRNA expression in head and neck cancer patients. Acta Otolaryngol. 2010 130:959-65 PubMed ID: 20100132

5611 Wakabayashi H, Narita T, Suga A, Sakagami H. Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives. In Vivo 2010 24(1):39-44 PubMed ID: 20133973

6120 Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Biochem Biophys Res Commun 2010 391(4):1785-91 PubMed ID: 20045673

6122 Nomi N, Kodama S, Suzuki M. Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway. Oncol Rep 2010 24(1):225-31 PubMed ID: 20514466

6123 Yuji Miyazaki　et al Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer J Cancer Sci Ther 2010 2(2) :26-32

13818 Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene Journal of Electromagnetic Analysis and Applications 2010 2:382-394

6127 Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H. Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines. Anticancer Res 2009 29(8):3079-86 PubMed ID: 19661319

6128 Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A. Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure. Anticancer Res 2009 29(1):455-64 PubMed ID: 19331186

6129 Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H. Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives. Anticancer Res 2009 29(4):1123-30 PubMed ID: 19414354

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309

6136 Okamura M, Shimada J, Sakagami H. Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines. Anticancer Res 2008 28(1A):253-9 PubMed ID: 18383853

6138 Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines. Anticancer Res 2008 28(2A):1069-78 PubMed ID: 18507056

6141 Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I. Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma. Cancer Sci 2008 99(7):1390-400 PubMed ID: 18452558

6143 Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res. 2007 27(1A):133-43 PubMed ID: 17352225

6148 Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H. Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines. Anticancer Res 2006 26(3A):1917-23 PubMed ID: 16827125

6150 Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene 2006 25(8):1216-24 PubMed ID: 16247456

6152 Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H. Cytotoxic activity of azulenequinones against human oral tumor cell lines. Anticancer Res 2005 25(1A):305-12 PubMed ID: 15816552