CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1975 : HSC-3]

3303 Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S. Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium. In Vitro Cell Dev Biol 1990 26:849-856 PubMed ID: 2228902 DOI: 10.1007/BF02624609

3248 Ichijo H, Momose F, Miyazono K Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells. Exp Cell Res 1990 187:263-9 PubMed ID: 2156718 DOI: 10.1016/0014-4827(90)90090-w

3243 Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas. J Oral Pathol Med 1989 18:391-5 PubMed ID: 2585303 DOI: 10.1111/j.1600-0714.1989.tb01570.x

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23003 Komatsuda H, Nagato T, Kosaka A, Ohkuri T, Sasaki T, Kumai T, Kono M, Yamaki H, Wakisaka R, Yasuda S, Inoue T, Hayashi R, Ujiie N, Sato R, Ohara K, Kishibe K, Hayashi T, Takahara M, Kobayashi H. Tumor-promoting function of paternally expressed gene 10 and its immunogenicity in inducing anti-tumor helper T cells in head and neck squamous cell carcinoma. Cancer Immunol Immunother 2025 74(8):251 PubMed ID: 40560436 DOI: 10.1007/s00262-025-04110-3

19774 Kasamatsu A, Nozaki R, Kawasaki K, Saito T, Minemura C, Seki N, Moss J, Uzawa K. Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma Cancers (Basel) 2024 16(6):1242 PubMed ID: 38539573 DOI: 10.3390/cancers16061242

21577 Al Awadh AA, Sakagami H, Amano S, Sayed AM, Abouelela ME, Alhasaniah AH, Aldabaan N, Refaey MS, Abdelhamid RA, Khalil HMA, Hamdan DI, Abdel-Sattar ES, Orabi MAA. In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations. Front Pharmacol 2024 15:1325272 PubMed ID: 38303989 DOI: 10.3389/fphar.2024.1325272

21596 Hamada M, Inaba H, Nishiyama K, Yoshida S, Yura Y, Matsumoto-Nakano M, Uzawa N. Transcriptomic analysis of Porphyromonas gingivalis-infected head and neck cancer cells: Identification of PLAU as a candidate prognostic biomarker. J Cell Mol Med 2024 28(4) PubMed ID: 38363001 DOI: 10.1111/jcmm.18167

21696 Yoshimura T, Hirano Y, Hamada T, Yokoyama S, Suzuki H, Takayama H, Migita H, Ishida T, Nakamura Y, Ohsawa M, Asakawa A, Ishihata K, Tanimoto A. Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M. Cancers (Basel) 2024 16(6) PubMed ID: 38539521 DOI: 10.3390/cancers16061187

21708 Inomata M, Abe M, Kawase Y, Hayashi T, Amano S, Sakagami H. Dectin-1/SYK Activation Induces Antimicrobial Peptide and Negative Regulator of NF-κB Signaling in Human Oral Epithelial Cells. In Vivo 2024 38(3):1042-1048 PubMed ID: 38688646 DOI: 10.21873/invivo.13537

21752 Yonesi A, Tomihara K, Takatsuka D, Tachinami H, Yamazaki M, Jadidi ARY, Takaichi M, Imaue S, Fujiwara K, Yamada SI, Tanuma JI, Noguchi M. Rapamycin Induces Phenotypic Alterations in Oral Cancer Cells That May Facilitate Antitumor T Cell Responses. Biomedicines 2024 12(5) PubMed ID: 38791040 DOI: 10.3390/biomedicines12051078

21807 Takatsuka D, Tachinami H, Suzuki N, Yamazaki M, Yonesi A, Takaichi M, Imaue S, Yamada SI, Tanuma JI, Noguchi M, Tomihara K. PAK4 inhibition augments anti-tumour effect by immunomodulation in oral squamous cell carcinoma. Sci Rep 2024 14(1):14092 PubMed ID: 38890401 DOI: 10.1038/s41598-024-64126-0

22052 Abé T, Yamazaki M, Nozumi M, Maruyama S, Takamura K, Ohashi R, Ajioka Y, Tanuma JI. Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved in cell migration and epithelial phenotype. Sci Rep 2024 14(1):22778 PubMed ID: 39354061 DOI: 10.1038/s41598-024-74041-z

22313 Karki SS, Das U, Balzarini J, De Clercq E, Sakagami H, Uesawa Y, Roayapalley PK, Dimmock JR. Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones? Medicines (Basel) 2024 11(8) PubMed ID: 39584969 DOI: 10.3390/medicines11080019

19591 Kawasaki Y, Omori Y, Suzuki S, Yamada T. CD98hc as a marker of radiotherapy-resistant cancer stem cells in head and neck squamous cell carcinoma Arch Med Sci 2023 19(6):1859-1868 PubMed ID: 38058706 DOI: 10.5114/aoms.2020.92872

19730 Katase N, Kudo K, Ogawa K, Sakamoto Y, Nishimatsu SI, Yamauchi A, Fujita S. DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer Oral Dis 2023 29(8):3193-3204 PubMed ID: 35708905 DOI: 10.1111/odi.14277

19747 Komatsuda H, Wakisaka R, Kono M, Kumai T, Hayashi R, Yamaki H, Sato R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Takahara M, Katada A, Kobayashi H. Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation Cancer Sci 2023 114(2):399-409 PubMed ID: 36285482 DOI: 10.1111/cas.15619

19748 Yamaki H, Kono M, Wakisaka R, Komatsuda H, Kumai T, Hayashi R, Sato R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Hayashi T, Kobayashi H, Katada A. Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer Cancer Immunol Immunother 2023 72(8):2799-2812 PubMed ID: 37173455 DOI: 10.1007/s00262-023-03460-0

19759 Takanori Takenawa, Koji Harada, Tarannum Ferdous, Keisuke Kawasaki, Yasuhiro Kuramitsu, Katsuaki Mishima Silencing of Tropomyosin 1 suppresses the proliferation, invasion and metastasis of oral squamous cell carcinoma in vitro Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023 35:282-287 DOI: 10.1016/j.ajoms.2022.10.004

19875 Abe T, Sakagami H, Amano S, Uota S, Bandow K, Uesawa Y, U S, Shibata H, Takemura Y, Kimura Y, Takao K, Sugita Y, Sato A, Tanuma SI, Takeshima H. A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs Medicines (Basel) 2023 10(7):43 PubMed ID: 37505064 DOI: 10.3390/medicines10070043

21184 Chan NN, Yamazaki M, Maruyama S, Abé T, Haga K, Kawaharada M, Izumi K, Kobayashi T, Tanuma JI. Cholesterol Is a Regulator of CAV1 Localization and Cell Migration in Oral Squamous Cell Carcinoma. Int J Mol Sci 2023 24(7) PubMed ID: 37047005 DOI: 10.3390/ijms24076035

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

21527 Orabi MAA, Orabi EA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Sakagami H, Hatano T. New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines. Antioxidants (Basel) 2023 12(11) PubMed ID: 38001804 DOI: 10.3390/antiox12111951

22959 Ohara G, Okabe K, Toyama N, Ohta Y, Xinman S, Ichimura N, Sato K, Urata Y, Hibi H. Hyperthermia maintains death receptor expression and promotes TRAIL-induced apoptosis J Oral Pathol Med 2023 52(8):718-726 PubMed ID: 37317871 DOI: 10.1111/jop.13457

17668 Tsukasa SAKAMOTO , Yuichi OHNISHI, Masami NOZAKI, Masahiro NAKAJIMA, Tomoharu OKAMURA, Kazuya TOMINAGA Relation to HGF/c‐Met pathway and PD‐L1 expression in oral squamous cell carcinoma Journal of Osaka Dental University 2022 56:51-61 DOI: 10.18905/jodu.56.1_51

20382 Fan M, Arai M, Tawada A, Chiba T, Fukushima R, Uzawa K, Shiiba M, Kato N, Tanzawa H, Takiguchi Y. Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers. Oncol Rep 2022 47(1) PubMed ID: 34738627 DOI: 10.3892/or.2021.8216

20513 Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y. Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma. Oncoimmunology 2022 11(1):2021619 PubMed ID: 35003900 DOI: 10.1080/2162402X.2021.2021619

20544 Matsuda R, Sakagami H, Amano S, Iijima Y, Sano M, Uesawa Y, Tamura N, Oishi Y, Takeshima H. Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid. Anticancer Res 2022 42(2):781-790 PubMed ID: 35093876 DOI: 10.21873/anticanres.15536

16180 Katsuhiro Asaka, Akira Fukatsu, Chiaki Komine The Effectiveness of a Portable Fluorescence Spectrophotometer for Early Detection of Oral Cancer Open Journal of Stomatology 2022 12:30-31 DOI: 10.4236/ojst.2022.121003

16203 Sasabe E, Tomomura A, Liu H, Sento S, Kitamura N, Yamamoto T. Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis Cancer Sci 2022 113(2):609-621 PubMed ID: 34874595 DOI: 10.1111/cas.15225

20648 Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H. Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives. Int J Mol Sci 2022 23(5) PubMed ID: 35269748 DOI: 10.3390/ijms23052601

20815 Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR. Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells. Medicines (Basel) 2022 9(6) PubMed ID: 35736248 DOI: 10.3390/medicines9060035

17100 Izumi A, Yamamoto K, Kawaguchi M, Yamashita F, Fukushima T, Kiwaki T, Tanaka H, Yamashita Y, Kataoka H. Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells Cancer Sci 2022 113(6):2179-2193 PubMed ID: 35332604 DOI: 10.1111/cas.15346

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20932 Katase N, Nishimatsu SI, Yamauchi A, Okano S, Fujita S. Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC). Cancer Cell Int 2022 22(1):352 PubMed ID: 36376957 DOI: 10.1186/s12935-022-02783-9

20970 Murakami K, Umemura N, Adachi M, Motoki M, Ohkoshi E. ABCG2, CD44 and SOX9 are increased with the acquisition of drug resistance and involved in cancer stem cell activities in head and neck squamous cell carcinoma cells. Exp Ther Med 2022 24(6):722 PubMed ID: 36340608 DOI: 10.3892/etm.2022.11658

20085 Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H. Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Sci Rep 2021 11(1):5897 PubMed ID: 33723306 DOI: 10.1038/s41598-021-85242-1

20133 Nakamura A, Kakihara Y, Funayama A, Haga K, Mikami T, Kobayashi D, Yoshida Y, Izumi K, Kobayashi T, Saeki M. HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma. Biochem Biophys Res Commun 2021 557:294-301 PubMed ID: 33894417 DOI: 10.1016/j.bbrc.2021.04.021

14869 Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K. miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells Sci Rep 2021 11(1):13502 PubMed ID: 34226586 DOI: 10.1038/s41598-021-92879-5

20350 Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI. Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression. Transl Oncol 2021 14(12):101236 PubMed ID: 34624685 DOI: 10.1016/j.tranon.2021.101236

20406 Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K. High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines. Heliyon 2021 7(11):e08318 PubMed ID: 34816032 DOI: 10.1016/j.heliyon.2021.e08318

20438 Yang KH, Tang JY, Chen YN, Chuang YT, Tsai IH, Chiu CC, Li LJ, Chien TM, Cheng YB, Chang FR, Yen CY, Chang HW. Nepenthes Extract Induces Selective Killing, Necrosis, and Apoptosis in Oral Cancer Cells. J Pers Med 2021 11(9) PubMed ID: 34575651 DOI: 10.3390/jpm11090871

15868 Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K. Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma Oncol Lett 2021 22(4):730 PubMed ID: 34429770 DOI: 10.3892/ol.2021.12991

16099 Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E. PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1 Int J Oncol 2021 58(6):29 PubMed ID: 33887877 DOI: 10.3892/ijo.2021.5209

16112 Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M. Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells Oral Surg Oral Med Oral Pathol Oral Radiol 2021 132(5):549-565 PubMed ID: 34518137 DOI: 10.1016/j.oooo.2021.04.006

16136 Harada K, Ferdous T, Watanabe K, Mizukami Y, Mishima K. Effects of an elemental diet, Elental®, may differ between healthy oral cells and oral cancer cells Oncol Rep 2021 45(2):738-751 PubMed ID: 33416174 DOI: 10.3892/or.2020.7896

16138 Ando T, Kasamatsu A, Kawasaki K, Hiroshima K, Fukushima R, Iyoda M, Nakashima D, Endo-Sakamoto Y, Uzawa K. Tumor Suppressive Circular RNA-102450: Development of a Novel Diagnostic Procedure for Lymph Node Metastasis from Oral Cancer Cancers (Basel) 2021 13(22):5708 PubMed ID: 34830863 DOI: 10.3390/cancers13225708

16139 Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma Int J Mol Sci 2021 22(23):12684 PubMed ID: 34884487 DOI: 10.3390/ijms222312684

16173 Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S. Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels Nat Biomed Eng 2021 5(8):914-925 PubMed ID: 33782572 DOI: 10.1038/s41551-021-00692-2

16196 Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S. Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue Medicines (Basel) 2021 8(7):33 PubMed ID: 34206186 DOI: 10.3390/medicines8070033

16206 Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma Int J Mol Sci 2021 22(18):9947 PubMed ID: 34576110 DOI: 10.3390/ijms22189947

16862 Kawasaki M, Sakabe T, Kodani I, Umekita Y. Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma Anticancer Res 2021 41(9):4563-4570 PubMed ID: 34475084 DOI: 10.21873/anticanres.15269

16975 Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K. Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Res 2021 41(4):1821-1830 PubMed ID: 33813387 DOI: 10.21873/anticanres.14948

11844 Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M. CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity. Oral Dis 2020 26(4):745-755 PubMed ID: 31603606 DOI: 10.1111/odi.13210

11965 Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T. The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. Lab. Invest. 2020 PubMed ID: 31857698 DOI: 10.1038/s41374-019-0357-z

13013 Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H. Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation. In Vivo 2020 PubMed ID: 32354886 DOI: 10.21873/invivo.11869

13093 Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. Protection of Bortezomib-induced Neurotoxicity by Antioxidants. Anticancer Res 2020 PubMed ID: 32620607 DOI: 10.21873/anticanres.14357

13148 Tang JY, Wu KH, Wang YY, Farooqi AA, Huang HW, Yuan SF, Jian RI, Tsao LY, Chen PA, Chang FR, Cheng YB, Hu HC, Chang HW. Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress. Antioxidants (Basel) 2020 PubMed ID: 32756347 DOI: 10.3390/antiox9080694

13205 Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H. Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro. Anticancer Res 2020 PubMed ID: 32878776 DOI: 10.21873/anticanres.14491

13401 Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. Oncoimmunology 2020 PubMed ID: 33457076 DOI: 10.1080/2162402X.2020.1856545

13783 Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy Cancer Sci 2020 111(1):127-136. PubMed ID: 31692172 DOI: 10.1111/cas.14224

13892 Nguyen CTK, Sawangarun W, Mandasari M, Morita KI, Harada H, Kayamori K, Yamaguchi A, Sakamoto K. AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression PLoS One 2020 15(2):e0222689 PubMed ID: 32012175 DOI: 10.1371/journal.pone.0222689

13903 Aika Tanzawa et al. Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma Oral Science International 2020 17(2):67-72 DOI: 10.1002/osi2.1044

13920 Kazutaka KIMURA, Yuichi OHNISHI, Tomoharu OKAMURA, Kazuya TOMINAGA, Masahiro NAKAJIMA Effect of HGF/c-Met pathway in oral squamous cell carcinoma on EMT and metastatic potential Journal of Osaka Dental University 2020 54(1):135-144 DOI: 10.18905/jodu.54.1_135

10691 Iwai S, Kishimoto S, Amano Y, Nishiguchi A, Matsusaki M, Takeshita A, Akashi M. Three-dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion. J Biomed Mater Res A 2019 107(2):292-300 PubMed ID: 29280265 DOI: 10.1002/jbm.a.36319

11300 Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A. Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma. Int. J. Oncol. 2019 PubMed ID: 30431077 DOI: 10.3892/ijo.2018.4631

11350 Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Fujita S. DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways. Int. J. Oncol. 2019 PubMed ID: 30569110 DOI: 10.3892/ijo.2018.4667

11354 Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K. Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30587341 DOI: 10.1016/j.bbrc.2018.12.066

6020 Matsuo K, Suzuki H, Yatagai N, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Matsumoto K, Komori T. Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line. Kobe J Med Sci 2019 64(6):E210-E216 PubMed ID: 31327864

11584 Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW. Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress. Environ. Toxicol. 2019 PubMed ID: 31157515 DOI: 10.1002/tox.22748

11590 Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW. Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells. DNA Cell Biol. 2019 PubMed ID: 31170002 DOI: 10.1089/dna.2018.4436

11620 Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H. Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives. Anticancer Res. 2019 PubMed ID: 31262875 DOI: 10.21873/anticanres.13497

11759 Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H. Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma. Sci Rep 2019 PubMed ID: 31434965 DOI: 10.1038/s41598-019-48717-w

9696 Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma Exp Cell Res 2019 384(2):111622 PubMed ID: 31518558 DOI: 10.1016/j.yexcr.2019.111622

9810 Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves Plant Signal Behav 2019 14(10):e1644594 PubMed ID: 31342859 DOI: 10.1080/15592324.2019.1644594

9890 Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement J Cancer 2019 10(16):3728-3734 PubMed ID: 31333790 DOI: 10.7150/jca.32281

11907 Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Dis. Markers 2019 PubMed ID: 31019584 DOI: 10.1155/2019/8040361

11931 Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs. Anticancer Res. 2019 PubMed ID: 31810932 DOI: 10.21873/anticanres.13882

11933 Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones. Anticancer Res. 2019 PubMed ID: 31810912 DOI: 10.21873/anticanres.13862

12457 Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. SYT12 plays a critical role in oral cancer and may be a novel therapeutic target J Cancer 2019 10(20):4913-4920 PubMed ID: 31598163 DOI: 10.7150/jca.32582

12459 Krishnan NM, Katoh H, Palve V, Pareek M, Sato R, Ishikawa S, Panda B. Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma PeerJ 2019 7:e6464 PubMed ID: 30842898 DOI: 10.7717/peerj.6464

12460 Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H. LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer Oncotarget 2019 10(10):1014-1030 PubMed ID: 30800215 DOI: 10.18632/oncotarget.26583

12586 Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner J Clin Biochem Nutr 2019 65(1):8-15 PubMed ID: 31379408 DOI: 10.3164/jcbn.18-91

10649 Koshizuka K, Hanazawa T, Kikkawa N, Katada K, Okato A, Arai T, Idichi T, Osako Y, Okamoto Y, Seki N. Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma. Auris Nasus Larynx 2018 45:854-865 PubMed ID: 29233721 DOI: 10.1016/j.anl.2017.11.019

10664 Ohnishi Y, Yasui H, Nozaki M, Nakajima M. Molecularly-targeted therapy for the oral cancer stem cells. Jpn Dent Sci Rev 2018 54:88-103 PubMed ID: 29755619 DOI: 10.1016/j.jdsr.2017.11.001

10668 Ikehata N, Takanashi M, Satomi T, Watanabe M, Hasegawa O, Kono M, Enomoto A, Chikazu D, Kuroda M. Toll-like receptor 2 activation implicated in oral squamous cell carcinoma development. Biochem. Biophys. Res. Commun. 2018 495:2227-2234 PubMed ID: 29269299 DOI: 10.1016/j.bbrc.2017.12.098

10724 Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters. Anticancer Res. 2018 38:817-823 PubMed ID: 29374707 DOI: 10.21873/anticanres.12289

10806 Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp. Cell Res. 2018 367:112-118 PubMed ID: 29614312 DOI: 10.1016/j.yexcr.2018.03.041

10829 Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H. In Vitro Anti-tumor Activity of Azulene Amide Derivatives. In Vivo 2018 32:479-486 PubMed ID: 29695549 DOI: 10.21873/invivo.11264

11110 Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants. In Vivo 2018 32(4):745-752 PubMed ID: 29936454 DOI: 10.21873/invivo.11303

11115 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(7):3897-3906 PubMed ID: 29970510 DOI: 10.21873/anticanres.12674

11148 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(8):4459-4467 PubMed ID: 30061210 DOI: 10.21873/anticanres.12748

11226 Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer 2018 PubMed ID: 30271493 DOI: 10.7150/jca.25666

11306 Kakuguchi W, Nomura T, Kitamura T, Otsuguro S, Matsushita K, Sakaitani M, Maenaka K, Tei K. Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells. Cancer Med 2018 PubMed ID: 30449075 DOI: 10.1002/cam4.1877

4173 Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H. In Vitro Antitumor Activity of Alkylaminoguaiazulenes. In Vivo 2018 PubMed ID: 29695558 DOI: 10.21873/invivo.11273

4235 Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget 2018 PubMed ID: 30333913 DOI: 10.18632/oncotarget.26112

4236 Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncol. Rep. 2018 PubMed ID: 29192320 DOI: 10.3892/or.2017.6105

4237 Yamanouchi R, Harada K, Ferdous T, Ueyama Y. Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Mol Clin Oncol 2018 PubMed ID: 29456845 DOI: 10.3892/mco.2018.1548

4238 Sumi S, Umemura N, Adachi M, Ohta T, Naganawa K, Kawaki H, Takayama E, Kondoh N, Sumitomo S. The luminance ratio of autofluorescence in a xenograft mouse model is stable through tumor growth stages. Clin Exp Dent Res 2018 PubMed ID: 30386639 DOI: 10.1002/cre2.126

4239 Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D. Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma. Int. J. Oncol. 2018 PubMed ID: 29344674 DOI: 10.3892/ijo.2018.4247

4240 Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M. DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4. Arch. Oral Biol. 2018 PubMed ID: 29522917 DOI: 10.1016/j.archoralbio.2018.02.016

4241 Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI. Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma. Oncol. Rep. 2018 PubMed ID: 30132562 DOI: 10.3892/or.2018.6665

4242 Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y. Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. Int. J. Oncol. 2018 PubMed ID: 29115586 DOI: 10.3892/ijo.2017.4181

14824 Chung MK, Jung YH, Lee JK, Cho SY, Murillo-Sauca O, Uppaluri R, Shin JH, Sunwoo JB. CD271 Confers an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug Clin Cancer Res 2018 24(3):674-683 PubMed ID: 29208672 DOI: 10.1158/1078-0432.CCR-17-0866

14677 Yamamoto K, Kawaguchi M, Shimomura T, Izumi A, Konari K, Honda A, Lin CY, Johnson MD, Yamashita Y, Fukushima T, Kataoka H. Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/ SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells Oncotarget 2018 9(14):11691-11706. PubMed ID: 29545930 DOI: 10.18632/oncotarget.24450

16201 Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K. Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer Lab Invest 2018 98(8):980-988 PubMed ID: 29855544 DOI: 10.1038/s41374-018-0070-3

16207 Akihiro Ito, Mitsuhiko Ohta, Yukinari Kato, Shunko Inada, Toshio Kato , Susumu Nakata, Yasushi Yatabe, Mitsuo Goto, Norio Kaneda , Kenichi Kurita, Hayao Nakanishi, Kenji Yoshida A Real-Time Near-Infrared Fluorescence Imaging Method for the Detection of Oral Cancers in Mice Using an Indocyanine Green-Labeled Podoplanin Antibody Technol Cancer Res Treat 2018 1533033818767936. PubMed ID: 29649929 DOI: 10.1177/1533033818767936

10044 Ohkoshi E, Umemura N. Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells. Int. J. Oncol. 2017 50:387-395 PubMed ID: 28035370 DOI: 10.3892/ijo.2016.3821

10148 Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Exp. Cell Res. 2017 352:357-363 PubMed ID: 28237246 DOI: 10.1016/j.yexcr.2017.02.026

10191 Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem. Biophys. Res. Commun. 2017 486:385-390 PubMed ID: 28315328 DOI: 10.1016/j.bbrc.2017.03.050

10197 Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T. Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin. Anticancer Res. 2017 37:1023-1029 PubMed ID: 28314260 DOI: 10.21873/anticanres.11412

10201 Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Chalcones. Anticancer Res. 2017 37:1091-1098 PubMed ID: 28314269 DOI: 10.21873/anticanres.11421

10206 Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T. Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas. Molecules 2017 22: PubMed ID: 28294988 DOI: 10.3390/molecules22030470

10241 Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M. A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem. Pharm. Bull. 2017 65:365-372 PubMed ID: 28381677 DOI: 10.1248/cpb.c16-00830

10386 Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y. Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices. In Vivo 2017 31:591-598 PubMed ID: 28652425 DOI: 10.21873/invivo.11099

10576 Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters. Anticancer Res. 2017 37:6161-6168 PubMed ID: 29061797 DOI: 10.21873/anticanres.12065

11036 Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation Int J Cancer Oncol 2017 4: 225- 230 DOI: 10.15436/2377-0902.17.1628

6024 Hamada M, Kameyama H, Iwai S, Yura Y. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov 2017 3:17047 PubMed ID: 29109864 DOI: 10.1038/cddiscovery.2017.47

14254 Koshizuka K, Nohata N, Hanazawa T, Kikkawa N, Arai T, Okato A, Fukumoto I, Katada K, Okamoto Y, Seki N. Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs Oncotarget 2017 8(18):30288-30304 PubMed ID: 28415821 DOI: 10.18632/oncotarget.16327

14365 Koshizuka K, Hanazawa T, Kikkawa N, Arai T, Okato A, Kurozumi A, Kato M, Katada K, Okamoto Y, Seki N. Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer Cancer Sci 2017 108(8):1681-1692 PubMed ID: 28612520 DOI: 10.1111/cas.13298

7096 Yoshino F, Yoshida A, Toyama T, Wada-T S, Takahashi S α-Glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch. J Functional Foods 2016 21:223-231 DOI: 10.1016/j.jff.2015.12.008

9584 Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H. Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline. In Vivo 2016 30:91-7 PubMed ID: 26912818

9616 Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer 2016 7:600-7 PubMed ID: 27053959 DOI: 10.7150/jca.13820

9630 Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma. J Cancer 2016 7:702-10 PubMed ID: 27076852 DOI: 10.7150/jca.14208

9654 Kumasaka A, Matsumoto N, Mukae S, Kitano T, Noguchi H, Ohki H, Komiyama K, Ando T. Rapid and Specific Screening Assay for KRAS Oncogene Mutation by a Novel Gene Amplification Method. Anticancer Res. 2016 36:1571-9 PubMed ID: 27069133

9676 Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A. Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production. Anticancer Res. 2016 36:2161-8 PubMed ID: 27127118

9694 Harada K, Ferdous T, Harada T, Ueyama Y. Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. Int. J. Oncol. 2016 49:276-84 PubMed ID: 27210058 DOI: 10.3892/ijo.2016.3523

9762 Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M. Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. PLoS ONE 2016 11:e0159693 PubMed ID: 27441818 DOI: 10.1371/journal.pone.0159693

9808 Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H. Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone. In Vivo 2016 30:645-50 PubMed ID: 27566085

9851 Masui A, Hamada M, Kameyama H, Wakabayashi K, Takasu A, Imai T, Iwai S, Yura Y. Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis. PLoS ONE 2016 11:e0162786 PubMed ID: 27658240 DOI: 10.1371/journal.pone.0162786

9892 Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y. Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones. Anticancer Res. 2016 36:5803-5812 PubMed ID: 27793902 DOI: 10.21873/anticanres.11164

9896 Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y. Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata. Anticancer Res. 2016 36:5931-5935 PubMed ID: 27793918 DOI: 10.21873/anticanres.11180

9911 Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H. Antiviral and Antitumor Activity of Licorice Root Extracts. In Vivo 2016 30:777-785 PubMed ID: 27815461 DOI: 10.21873/invivo.10994

6032 Tada H, Shimizu T, Nagaoka I, Takada H. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res 2016 37(3):199-205 PubMed ID: 27356607 DOI: 10.2220/biomedres.37.199

6033 Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R. Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. Int J Oncol 2016 48(4):1670-8 PubMed ID: 26893131 DOI: 10.3892/ijo.2016.3391

6036 Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer. Int J Oncol. 2016 48(2):607-12 PubMed ID: 26718916 DOI: 10.3892/ijo.2015.3305

6042 Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa Cavin-2 in oral cancer: A potential predictor for tumor progression. Mol Carcinog 2016 55(6):1037-47 PubMed ID: 26086332 DOI: 10.1002/mc.22347

14162 Yamali C, Gul HI, Sakagami H, Supuran CT. Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases J Enzyme Inhib Med Chem 2016 31(sup4):125-131 PubMed ID: 27594305 DOI: 10.1080/14756366.2016.1221825

14178 Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T. Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra J Nat Prod 2016 79(4):984-95 PubMed ID: 26938659 DOI: 10.1021/acs.jnatprod.5b01065

7109 Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K. Telomerase activity in the occurrence and progression of oral squamous cell carcinoma. J Oral Sci 2015 57:295-303 PubMed ID: 26666852 DOI: 10.2334/josnusd.57.295

7175 Ohnishi Y, Yasui H, Kakudo K, Nozaki M. Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway. Int. J. Oncol. 2015 47:2165-72 PubMed ID: 26497980 DOI: 10.3892/ijo.2015.3215

7196 Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. Anticancer Res. 2015 35:5299-307 PubMed ID: 26408690

5422 Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5. Quantitative Structure-Cytotoxicity Relationship of Oleoylamides. Anticancer Res 2015 5(10):5341-51 PubMed ID: 26408695

6043 Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y. Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells. Toxicol Rep 2015 2:1281-1290 PubMed ID: 28962471 DOI: 10.1016/j.toxrep.2015.09.009

6044 Kasama H　et al Adenosine A2b receptor promotes progression of human oral cancer. BMC Cancer 2015 15:563 PubMed ID: 26228921 DOI: 10.1186/s12885-015-1577-2

6051 Okamoto A　et al Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma. PLoS One 2015 10(11):e0142252 PubMed ID: 26554377 DOI: 10.1371/journal.pone.0142252

6052 Saito T et al Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis. PLoS One 2015 10(9):e0137923 PubMed ID: 26378920 DOI: 10.1371/journal.pone.0137923

6053 Miyamoto I et al Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth. Biochem Biophys Rep 2015 3:26-31 PubMed ID: 29124166 DOI: 10.1016/j.bbrep.2015.07.008

6058 Shida-Sakazume T et al Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. PLoS One. 2015 10(3):e0120143 PubMed ID: 25803864 DOI: 10.1371/journal.pone.0120143

15042 Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer Cancer Med 2015 4(5):759-69 PubMed ID: 25644496 DOI: 10.1002/cam4.418

10985 Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H. Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma Sci Rep 2015 5:16280 PubMed ID: 26538233 DOI: 10.1038/srep16280

6023 Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M. NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma. Oncol Lett 2014 7(1):35-40 PubMed ID: 24348816 DOI: 10.3892/ol.2013.1690

6006 Ohnishi Y, Watanabe M, Yasui H, Kakudo K. Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines. Oncol Lett 2014 7(5):1439-1442 PubMed ID: 24765152 DOI: 10.3892/ol.2014.1946

5916 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells. In Vivo 2014 28(4):549-56 PubMed ID: 24982221

5859 Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC. Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma. Biomed Res. 2014 35(6):381-8 PubMed ID: 25743344 DOI: 10.2220/biomedres.35.381

5807 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells. In Vivo 2014 28(5):895-907 PubMed ID: 25189906

5778 Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer. Mol Carcinog 2014 53(7):557-65 PubMed ID: 23371469 DOI: 10.1002/mc.22007

5659 Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of 3-styrylchromones. Anticancer Res 2014 34(10):5405-11 PubMed ID: 25275035

5605 Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M. Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing. PLoS One 2014 9(12):e114121 PubMed ID: 25437003 DOI: 10.1371/journal.pone.0114121

5544 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of phenylpropanoid amides. Anticancer Res 2014 34(7):3543-8 PubMed ID: 24982367

5337 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of piperic acid amides. Anticancer Res 2014 34(9):4877-84 PubMed ID: 25202069

5315 Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H. Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones. Anticancer Res 2014 4(4):1743-50 PubMed ID: 24692705

5307 Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor. J Transl Med 2014 12:265 PubMed ID: 25240937 DOI: 10.1186/s12967-014-0265-3

5122 Iida S, Shimada J, Sakagami H. Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines. In Vivo 2013 27(3):321-32 PubMed ID: 23606687

5110 Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res 2013 33(8):3061-8 PubMed ID: 23898061

5057 Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y. Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma. Int J Cancer. 2013 132(12):2755-66 PubMed ID: 23180648 DOI: 10.1002/ijc.27966

6070 Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013 139(4):533-42 PubMed ID: 23207790 DOI: 10.1007/s00432-012-1356-2

6071 Kondoh M, Ohga N, Akiyama K, Hida Y, Maishi N, Towfik AM, Inoue N, Shindoh M, Hida K. Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment. PLoS One 2013 8(11):e80349 PubMed ID: 24260373 DOI: 10.1371/journal.pone.0080349

6072 Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One 2013 8(2):e56381 PubMed ID: 23418564 DOI: 10.1371/journal.pone.0056381

6076 Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Kinesin family member 4A: a potential predictor for progression of human oral cancer. PLoS One. 2 2013 8(12):e85951 PubMed ID: 24386490 DOI: 10.1371/journal.pone.0085951

6077 Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma. J Oral Pathol Med 2013 42(2):133-9 PubMed ID: 22672247 DOI: 10.1111/j.1600-0714.2012.01182.x

6078 Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K. Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J 2013 30(6):585-97 PubMed ID: 23242548 DOI: 10.1007/s10719-012-9458-2

6081 Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation. BMC Cancer 2013 13:555 PubMed ID: 24261884 DOI: 10.1186/1471-2407-13-555

6083 Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy. Br J Cancer 2013 109(8):2155-66 PubMed ID: 24045666 DOI: 10.1038/bjc.2013.577

15086 Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H. Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells Oncol Rep 2013 29(4):1349-55 PubMed ID: 23354949 DOI: 10.3892/or.2013.2251

7722 Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K. Comprehensive epigenetic analysis using oral rinse samples: a pilot study. J. Oral Maxillofac. Surg. 2012 70:1486-94 PubMed ID: 21821326 DOI: 10.1016/j.joms.2011.04.021

6087 Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K. Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines. J Oral Sci 2012 54(1):71-5 PubMed ID: 22466889 DOI: 10.2334/josnusd.54.71

6088 Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H. Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness. J Pathol 2012 228(2):181-92 PubMed ID: 22262311 DOI: 10.1002/path.3993

6089 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines. J Oral Sci 2012 54(3):241-50 PubMed ID: 23047035 DOI: 10.2334/josnusd.54.241

6095 Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H. Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma. Oncol Lett 2012 3(2):273-280 PubMed ID: 22740894 DOI: 10.3892/ol.2011.473

6098 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity. Tumour Biol 2012 33(1):183-94 PubMed ID: 22081310 DOI: 10.1007/s13277-011-0261-7

15671 Harada T, Harada K, Ueyama Y. The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma Int J Oncol 2012 41(2):565-72 PubMed ID: 22664937 DOI: 10.3892/ijo.2012.1501

7601 Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H. Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives. Anticancer Res. 2011 31:4231-8 PubMed ID: 22199286

7691 Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H. Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma. Cancer Sci. 2011 102:2164-71 PubMed ID: 21899661 DOI: 10.1111/j.1349-7006.2011.02096.x

6109 Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M. A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. Int J Oncol 2011 39(6):1401-5 PubMed ID: 21785818 DOI: 10.3892/ijo.2011.1137

6112 lHiroshi Inoue et al Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines Asian Journal of Oral and Maxillofacial Surgery 2011 23:1-6 DOI: 10.1016/j.ajoms.2010.10.001

6116 Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H. Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells. Oncol Rep 2011 25(3):795-802 PubMed ID: 21206983 DOI: 10.3892/or.2010.1130

6118 Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer Journal of Osaka Dental University 2011 45：31-36 DOI: 10.18905/jodu.45.1_31

8085 Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. In Vivo 2010 24:735-43 PubMed ID: 20952742

8383 Uemura N, Kodama S, Nomi N, Okamoto T, Suzuki M. Correlation between anti-survivin antibody and survivin mRNA expression in head and neck cancer patients. Acta Otolaryngol. 2010 130:959-65 PubMed ID: 20100132 DOI: 10.3109/00016480903555416

18753 Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K, Itoh H. Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC Oncol Rep 2010 23(6):1625-33 PubMed ID: 20428818 DOI: 10.3892/or_00000804

19126 Shintani S, Hamakawa H, Nakashiro K, Shirota T, Hatori M, Tanaka M, Kuroshita Y, Kurokawa Y. Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma Int J Oral Maxillofac Surg 2010 39(11):1115-9 PubMed ID: 20709497 DOI: 10.1016/j.ijom.2010.02.027

5611 Wakabayashi H, Narita T, Suga A, Sakagami H. Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives. In Vivo 2010 24(1):39-44 PubMed ID: 20133973

6120 Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Biochem Biophys Res Commun 2010 391(4):1785-91 PubMed ID: 20045673 DOI: 10.1016/j.bbrc.2009.12.156

6122 Nomi N, Kodama S, Suzuki M. Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway. Oncol Rep 2010 24(1):225-31 PubMed ID: 20514466 DOI: 10.3892/or_00000850

6123 Yuji Miyazaki　et al Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer J Cancer Sci Ther 2010 2(2) :26-32

13818 Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene Journal of Electromagnetic Analysis and Applications 2010 2:382-394 DOI: 10.4236/jemaa.2010.26050

18743 Takayama S, Hatori M, Kurihara Y, Kinugasa Y, Shirota T, Shintani S. Inhibition of TGF-beta1 suppresses motility and invasiveness of oral squamous cell carcinoma cell lines via modulation of integrins and down-regulation of matrix-metalloproteinases Oncol Rep 2009 21(1):205-10 PubMed ID: 19082463

6127 Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H. Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines. Anticancer Res 2009 29(8):3079-86 PubMed ID: 19661319

6128 Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A. Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure. Anticancer Res 2009 29(1):455-64 PubMed ID: 19331186

6129 Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H. Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives. Anticancer Res 2009 29(4):1123-30 PubMed ID: 19414354

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x

18691 Shimizu M, Imai M. Effect of the antibody immunotherapy by the anti-MUC1 monoclonal antibody to the oral squamous cell carcinoma in vitro Biol Pharm Bull 2008 31(12):2288-93 PubMed ID: 19043215 DOI: 10.1248/bpb.31.2288

6136 Okamura M, Shimada J, Sakagami H. Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines. Anticancer Res 2008 28(1A):253-9 PubMed ID: 18383853

6138 Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines. Anticancer Res 2008 28(2A):1069-78 PubMed ID: 18507056

6141 Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I. Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma. Cancer Sci 2008 99(7):1390-400 PubMed ID: 18452558 DOI: 10.1111/j.1349-7006.2008.00838.x

6143 Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res. 2007 27(1A):133-43 PubMed ID: 17352225

6148 Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H. Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines. Anticancer Res 2006 26(3A):1917-23 PubMed ID: 16827125

6150 Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene 2006 25(8):1216-24 PubMed ID: 16247456 DOI: 10.1038/sj.onc.1209158

6152 Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H. Cytotoxic activity of azulenequinones against human oral tumor cell lines. Anticancer Res 2005 25(1A):305-12 PubMed ID: 15816552