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Cell No. : Cell Name
RCB1974 : SAS  update : 2021/11/24
CommentHuman cell line derived from tongue cancer. Squamous cell carcinoma. TKG0470 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Takahashi, K.
Year of deposit 2004
Original cell TKG0470
Animal _human < Mammals
Genus Homo
Species sapiens
Tissue tongue
Disease name squamous cell carcinoma of tongue
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0470)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1675
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 85


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Reference
5067  Yoshida H, Hasegawa S, Kuromi H, Inagaki N, Seino S, Takahashi K, Sato K.  A variant form of laminin is responsible for the neurite outgrowth-promoting activity in conditioned medium from a squamous carcinoma cell line.  Connect Tissue Res  1993  30(1):23-35.  PubMed ID: 8149742

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User's Publication
20085  Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H.  Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.  Sci Rep  2021  11(1):5897  PubMed ID: 33723306
20133  Nakamura A, Kakihara Y, Funayama A, Haga K, Mikami T, Kobayashi D, Yoshida Y, Izumi K, Kobayashi T, Saeki M.  HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma.  Biochem Biophys Res Commun  2021  557:294-301  PubMed ID: 33894417
20227  Yamamoto K, Yamashita F, Kawaguchi M, Izumi A, Kiwaki T, Kataoka H, Kaneuji T, Yamashita Y, Fukushima T.  Decreased prostasin expression is associated with aggressiveness of oral squamous cell carcinoma.  Hum Cell  2021    PubMed ID: 34250582
15868  Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K.  Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma  Oncol Lett  2021  22(4):730  PubMed ID: 34429770
11965  Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T.  The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.  Lab. Invest.  2020    PubMed ID: 31857698
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870
12128  Hazawa M, Yoshino H, Nakagawa Y, Shimizume R, Nitta K, Sato Y, Sato M, Wong RW, Kashiwakura I.  Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines.  Cancers (Basel)  2020    PubMed ID: 32276424
13063  Yamamoto T, Hirosue A, Nakamoto M, Yoshida R, Sakata J, Matsuoka Y, Kawahara K, Nagao Y, Nagata M, Takahashi N, Hiraki A, Shinohara M, Nakao M, Saitoh N, Nakayama H.  BRD4 promotes metastatic potential in oral squamous cell carcinoma through the epigenetic regulation of the MMP2 gene.  Br J Cancer  2020    PubMed ID: 32499570
13102  Takahashi K, Akatsu Y, Podyma-Inoue KA, Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T.  Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer.  J Biol Chem  2020    PubMed ID: 32631954
13781  Yamazaki M, Maruyama S, Abé T, Tsuneki M, Kato H, Izumi K, Tanuma JI, Cheng J, Saku T.  Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression  Exp Cell Res  2020  392(1):112013  PubMed ID: 32320683
13903  Aika Tanzawa et al.  Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma  Oral Science International  2020  17(2):67-72 
14501  Ichikawa T, Shanab O, Nakahata S, Shimosaki S, Manachai N, Ono M, Iha H, Shimoda K, Morishita K.  Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2 low ATL and various cancer cells  Biochim Biophys Acta Mol Cell Res  2020  1867(2):118615  PubMed ID: 31765670
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341
11377  Inoue K, Hatano K, Hanamatsu Y, Saigo C, Kito Y, Bunai K, Shibata T, Takeuchi T.  Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma.  J. Cancer Res. Clin. Oncol.  2019    PubMed ID: 30635792
11405  Uzawa K, Kasamatsu A, Saito T, Kita A, Sawai Y, Toeda Y, Koike K, Nakashima D, Endo Y, Shiiba M, Takiguchi Y, Tanzawa H.  Growth suppression of human oral cancer cells by candidate agents for cetuximab-side effects.  Exp. Cell Res.  2019    PubMed ID: 30690028
11497  Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S.  Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells.  J. Biochem.  2019    PubMed ID: 30918974
11616  Hano K, Hatano K, Saigo C, Kito Y, Shibata T, Takeuchi T.  An adiponectin paralog protein, CTRP6 decreased the proliferation and invasion activity of oral squamous cell carcinoma cells: possible interaction with laminin receptor pathway.  Mol. Biol. Rep.  2019    PubMed ID: 31254244
11759  Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H.  Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma.  Sci Rep  2019    PubMed ID: 31434965
11775  Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M.  Evaluation of IC50 levels immediately after treatment with anticancer reagents using a real-time cell monitoring device.  Exp Ther Med  2019    PubMed ID: 31555392
9696  Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa  Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma  Exp Cell Res  2019  384(2):111622  PubMed ID: 31518558
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114
9890  Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa  Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement  J Cancer  2019  10(16):3728-3734  PubMed ID: 31333790
11921  Okada R, Koshizuka K, Yamada Y, Moriya S, Kikkawa N, Kinoshita T, Hanazawa T, Seki N.  Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma.  Cells  2019    PubMed ID: 31795200
12457  Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  SYT12 plays a critical role in oral cancer and may be a novel therapeutic target  J Cancer  2019  10(20):4913-4920  PubMed ID: 31598163
12460  Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H.  LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer  Oncotarget  2019  10(10):1014-1030  PubMed ID: 30800215
12585  Suzuki S, Toyoma S, Tsuji T, Kawasaki Y, Yamada T.  CD147 mediates transforming growth factor-β1-induced epithelial-mesenchymal transition and cell invasion in squamous cell carcinoma of the tongue  Exp Ther Med  2019  17(4):2855-2860  PubMed ID: 30906472
12586  Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S.  Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner  J Clin Biochem Nutr  2019  65(1):8-15  PubMed ID: 31379408
10549  Adachi Y, Yoshimura M, Nishida K, Usuki H, Shibata K, Hattori M, Kondo N, Yatabe Y, Iwata H, Kikumori T, Kodera Y, Nakanishi H.  Acute phase dynamics of circulating tumor cells after paclitaxel and doxorubicin chemotherapy in breast cancer mouse models.  Breast Cancer Res. Treat.  2018  167:439-450  PubMed ID: 29027049
10623  Bunai K, Okubo H, Hano K, Inoue K, Kito Y, Saigo C, Shibata T, Takeuchi T.  TMEM207 hinders the tumour suppressor function of WWOX in oral squamous cell carcinoma.  J. Cell. Mol. Med.  2018  22:1026-1033  PubMed ID: 29164763
10649  Koshizuka K, Hanazawa T, Kikkawa N, Katada K, Okato A, Arai T, Idichi T, Osako Y, Okamoto Y, Seki N.  Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma.  Auris Nasus Larynx  2018  45:854-865  PubMed ID: 29233721
10664  Ohnishi Y, Yasui H, Nozaki M, Nakajima M.  Molecularly-targeted therapy for the oral cancer stem cells.  Jpn Dent Sci Rev  2018  54:88-103  PubMed ID: 29755619
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312
10820  Fukamachi M, Kasamatsu A, Endo-Sakamoto Y, Fushimi K, Kasama H, Iyoda M, Minakawa Y, Shiiba M, Tanzawa H, Uzawa K.  Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.  Exp. Cell Res.  2018  368:119-125  PubMed ID: 29679592
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493
11306  Kakuguchi W, Nomura T, Kitamura T, Otsuguro S, Matsushita K, Sakaitani M, Maenaka K, Tei K.  Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells.  Cancer Med  2018    PubMed ID: 30449075
4236  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Oncol. Rep.  2018    PubMed ID: 29192320
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845
4345  Hou B, Ishinaga H, Midorikawa K, Nakamura S, Hiraku Y, Oikawa S, Ma N, Takeuchi K, Murata M.  Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2.  Oncotarget  2018    PubMed ID: 29507664
14677  Yamamoto K, Kawaguchi M, Shimomura T, Izumi A, Konari K, Honda A, Lin CY, Johnson MD, Yamashita Y, Fukushima T, Kataoka H.  Hepatocyte growth factor activator inhibitor type-2 (HAI-2)/ SPINT2 contributes to invasive growth of oral squamous cell carcinoma cells  Oncotarget  2018  9(14):11691-11706.  PubMed ID: 29545930
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328
10395  Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.  Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma.  Int. J. Oncol.  2017  51:625-632  PubMed ID: 28656278
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404
10929    Assessment of Cytotoxicity of Imatinib for Oral Squamous Cell Carcinoma by a Real-Time Cell Analysis System.  Electronic Journal of Biology  2017  13: 56-62 
4555  Furukawa Y, Takasu A, Yura Y.  Role of autophagy in oncolytic herpes simplex virus type 1-induced cell death in squamous cell carcinoma cells.  Cancer Gene Ther.  2017  24(9):393-400  PubMed ID: 28984290
4574  Yasui H, Ohnishi Y, Nakajima M, Nozaki M.  Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.  Oncol Rep  2017  37(6):3674-3680  PubMed ID: 28440510
6024  Hamada M, Kameyama H, Iwai S, Yura Y.  Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.  Cell Death Discov  2017  3:17047  PubMed ID: 29109864
6027  lNorihisa Ichimura et al  Notch3 is frequently downregulated in oral cancer  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2017  29:504-510 
6029  Ishida S et al  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725
12679  Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K.  Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential  Cancer Res  2017  77(9):2363-2374  PubMed ID: 28209617
14231  Harada K, Ferdous T, Harada T, Takenawa T, Ueyama Y.  Gimeracil enhances the antitumor effect of cisplatin in oral squamous cell carcinoma cells in vitro and in vivo  Oncol Lett  2017  14(3):3349-3356.  PubMed ID: 28927087
14306  Noriko Komatsu, Kenichi Mitsui, Osamu Kusano-Arai, Hiroko Iwanari, Kazuto Hoshi, Tsuyoshi Takato, Takahiro Abe and Takao Hamakubo  Enhancement of anti-robo1 immunotoxin cytotoxicity to head and neck squamous cell carcinoma via photochemical internalization  Archives in Cancer Research  2017  5 
14365  Koshizuka K, Hanazawa T, Kikkawa N, Arai T, Okato A, Kurozumi A, Kato M, Katada K, Okamoto Y, Seki N.  Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer  Cancer Sci  2017  108(8):1681-1692  PubMed ID: 28612520
14638  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Regulation of cell migration via the EGFR signaling pathway in oral squamous cell carcinoma cells  Oncol Lett  2017  13(2):930-936  PubMed ID: 28356980
14649  Kuo YZ, Fang WY, Huang CC, Tsai ST, Wang YC, Yang CL, Wu LW.  Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer  Oncotarget  2017  8(9):15563-15583  PubMed ID: 28107185
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852
9762  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818
9851  Masui A, Hamada M, Kameyama H, Wakabayashi K, Takasu A, Imai T, Iwai S, Yura Y.  Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis.  PLoS ONE  2016  11:e0162786  PubMed ID: 27658240
9900  Harada K, Ferdous T, Ueyama Y.  Gimeracil Exerts Radiosensitizing Effects on Oral Squamous Cell Carcinoma Cells In Vitro and In Vivo.  Anticancer Res.  2016  36:5923-5930  PubMed ID: 27793917
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916
6042  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332
14581  Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, Kishi Y, Hamada Y, Masutani M.  Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo  Int J Mol Sci  2016  17(3):272  PubMed ID: 26927065
7175  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway.  Int. J. Oncol.  2015  47:2165-72  PubMed ID: 26497980
7532  IIKAWA N, YAMAMOTO Y, KAWASAKI Y, YOSHIOKA T, NISHIJIMA A, ENOMOTO K  Intra-Golgi Connexin26 behaves in a pro-oncogenic manner in head and neck cancer cells.  Akita J Med  2015  42:87-94 
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166
14460  Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I.  Effects of X‑ray irradiation in combination with ascorbic acid on tumor control  Mol Med Rep  2015  12(4):5449-54  PubMed ID: 26238154
14987  Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H.  Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression  Oncotarget  2015  6(32):33345-57  PubMed ID: 26452260
15057  Ohmura G, Tsujikawa T, Yaguchi T, Kawamura N, Mikami S, Sugiyama J, Nakamura K, Kobayashi A, Iwata T, Nakano H, Shimada T, Hisa Y, Kawakami Y.  Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC  Mol Cancer Res  2015  13(4):721-31  PubMed ID: 25421751
6003  Aoyama 1, Ota Y, Kajiwara K, Hirayama N, Kimura M.  Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma.  Biochem Biophys Res Commun  2014  452(4):980-5  PubMed ID: 25234595
6023  Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M.  NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma.  Oncol Lett  2014  7(1):35-40  PubMed ID: 24348816
6006  Ohnishi Y, Watanabe M, Yasui H, Kakudo K.  Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines.  Oncol Lett  2014  7(5):1439-1442  PubMed ID: 24765152
15800  Yoshida R, Nakayama H, Nagata M, Hirosue A, Tanaka T, Kawahara K, Nakagawa Y, Matsuoka Y, Sakata J, Arita H, Hiraki A, Shinohara M, Ito T.  Overexpression of nucleostemin contributes to an advanced malignant phenotype and a poor prognosis in oral squamous cell carcinoma  Br J Cancer  2014  111(12):2308-15  PubMed ID: 25314067
5057  Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y.  Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.  Int J Cancer.  2013  132(12):2755-66  PubMed ID: 23180648
6077  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247
7691  Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H.  Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma.  Cancer Sci.  2011  102:2164-71  PubMed ID: 21899661
6109  Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M.  A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions.  Int J Oncol  2011  39(6):1401-5  PubMed ID: 21785818
6111  Hiroshi Inoue, Yuichi Ohnishi, Masahiro Watanabe, Tomoko Fujii, Yuki Minamino, Yoshihide Ugaki, Suguru Dateoka, Mitsuchika Sugitatsu, Masayuki Tsunokuma, Hirohito Kubo, Masahiro Nakajima, Kenji Kakudo  Effect of EpCAM localization on proliferation of an oral squamous cell carcinoma cell line  Journal of Osaka Dental UniversityJournal of Osaka Dental University  2011  45:259-264 
6112  lHiroshi Inoue et al  Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines  Asian Journal of Oral and Maxillofacial Surgery   2011  23:1-6 
6118  Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo  Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer  Journal of Osaka Dental University  2011  45:31-36 
6122  Nomi N, Kodama S, Suzuki M.  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466



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