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Cell No. : Cell Name
RCB1963 : VMRC-RCW  update : 2023/05/02
CommentHuman renal cell carcinoma cell line. TKG0447 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Akiyama, M.
Year of deposit 2004
Original cell TKG0447
Animal _human < Mammals
Genus Homo
Species sapiens
Tissue kidney
Disease name renal cell carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University（TKG0447）
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1790
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 12


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Reference
3282  Emoto N, Isozaki O, Ohmura E, Ito F, Tsushima T, Shizume K, Demura H, Toma H  Basic fibroblast growth factor (FGF-2) in renal cell carcinoma, which is indistinguishable from that in normal kidney, is involved in renal cell carcinoma growth.  J Urol  1994  152:1626-31  PubMed ID: 7523715   DOI: 10.1016/s0022-5347(17)32492-8
3285  Kitamura M, Shirasawa T, Mitarai T, Muramatsu T, Maruyama N  A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines.  Am J Pathol  1993  142:425-31  PubMed ID: 8434639  
3284  Nishimura N, Kanda S, Yogi Y, Kawamura M, Nakamura M, Hyakutake H, Kanetake H, Saito Y  Secretion of autocrine growth-promoting activity by renal-carcinoma cells treated with 5-fluorouracil.  Int J Cancer  1992  52:105-9  PubMed ID: 1500215   DOI: 10.1002/ijc.2910520119
3283  Ikemoto S, Hayahara N, Wada S, Nishio S, Maekawa M  Combined effect of tumor necrosis factor alpha and anticancer chemotherapeutic agents against human renal carcinoma cell lines.  Eur Urol  1991  19:236-9  PubMed ID: 1855530   DOI: 10.1159/000473628

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User's Publication
10005  Soki Kashima, Takuya Maeda, Kyoko Masuda, Seiji Nagano, Takamitsu Inoue, Masashi Takeda, Yuka Kono, Takashi Kobayashi, Shigeyoshi Saito, Takahiro Higuchi, Hiroshi Ichise, Yuka Kobayashi, Keiko Iwaisako, Koji Terada, Yasutoshi Agata, Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Masaki Yasukawa, Osamu Ogawa, Tomonori Habuchi, Hiroshi Kawamoto  Cytotoxic T Lymphocytes Regenerated From iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model  iScience  2020  23(4):100998  PubMed ID: 32259478   DOI: 10.1016/j.isci.2020.100998
11922  Isono T, Suzaki M.  Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines.  PLoS ONE  2019    PubMed ID: 31774870   DOI: 10.1371/journal.pone.0225721
4371  Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Yonese J, Yuasa T.  Abundance of TRAIL attenuated by HIF2α and c-FLIP affects malignancy in renal cell carcinomas.  Oncotarget  2018  9(33):23091-23101  PubMed ID: 29796174   DOI: 10.18632/oncotarget.25214
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2017  8:2890-2905  PubMed ID: 27926516   DOI: 10.18632/oncotarget.13761
9731  Mizutani N, Abe M, Matsuoka S, Kajino K, Wakiya M, Ohtsuji N, Hatano R, Morimoto C, Hino O.  Establishment of anti-mesothelioma monoclonal antibodies.  BMC Res Notes  2016  9:324  PubMed ID: 27342200   DOI: 10.1186/s13104-016-2128-x
9920  Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Suzaki M, Yuasa T.  Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas.  Am J Cancer Res  2016  6:2263-2276  PubMed ID: 27822416  
9921  Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, Reber LL, Pirottin D, Kim J, Chambon P, Roers A, Antoine N, Kawakami Y, Kawakami T, Bureau F, Tam SY, Tsai M, Galli SJ.  Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.  J. Clin. Invest.  2016  126:4497-4515  PubMed ID: 27820702   DOI: 10.1172/JCI86359
6403  Terasaka N, Futai K, Katoh T, Suga H.  A human microRNA precursor binding to folic acid discovered by small RNA transcriptomic SELEX.  RNA  2016  22(12):1918-1928  PubMed ID: 27852928   DOI: 10.1261/rna.057737.116
3744  Nakamura R, Oyama T, Tajiri R, Mizokami A, Namiki M, Nakamoto M, Ooi A.  Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.  Cancer Sci  2015  106(5):656-64  PubMed ID: 25726761   DOI: 10.1111/cas.12649
6384  Hidenori Kawashima Sakae Masaki Marie Kawamura  Induction of HLA‑A* 33‑restricted cytotoxic lymphocytes against renal cell carcinoma targeting galectin 9 and PINCH  Biomedical Reports  2014  2:809-812  PubMed ID: 25279150   DOI: 10.3892/br.2014.334
18125  Naoe M, Ogawa Y, Hasebe Y, Morita J, Shichijo T, Igarashi A, Fuji K, Iwamoto S, Suzuki T, Terao S.  Enhancement of IL-2-induced cytotoxicity by interferon-alpha in renal cell carcinoma  Oncol Res  2011  19(10-11):479-86  PubMed ID: 22715591   DOI: 10.3727/096504012x13285365944373
5012  Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K.  Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.  Hum Mol Genet  2006  15(6):821-30  PubMed ID: 16439445   DOI: 10.1093/hmg/ddl001


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