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細胞番号 : 細胞名
RCB1954 : T98G  update : 2021/02/26
細胞特性(Comment:英)Human cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト glioblastoma multiforme (Caucasian)由来細胞株. Hyperpentaploid chromosome count。 TKG0471 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
寄託日 2004
元の細胞 TKG0471
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Male
61 years
採取組織 brain
病名 glioblastoma multiforme tumor
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0471)
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
アイソザイム検査 LD, NP
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 2件
Reference(日) 0件
利用者成果(英) 23件
利用者成果(日) 0件

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Reference(英)
4618  Stein GH, Yanishevsky RM.  Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons.  Proc Natl Acad Sci U S A  1981  78(5):3025-9  PubMed ID: 6265932
3267  Stein, G H  T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro.  J Cell Physiol  1979  99:43-54  PubMed ID: 222778

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Reference(日)

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利用者成果(英)
13413  Hayashima K, Kimura I, Katoh H.  Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.  Biochem Biophys Res Commun  2021    PubMed ID: 33421769
12121  Yamaguchi I, Yoshimura SH, Katoh H.  High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).  J. Biol. Chem.  2020    PubMed ID: 32265299
12999  Kinashi Y, Ikawa T, Takahashi S.  The combined effect of neutron irradiation and temozolomide on glioblastoma cell lines with different MGMT and P53 status.  Appl Radiat Isot  2020    PubMed ID: 32561044
11419  Feng S, Cai X, Li Y, Jian X, Zhang L, Li B.  Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells.  J. Exp. Clin. Cancer Res.  2019    PubMed ID: 30728039
4672  Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y.  Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.  Cancer Res  2019  79(19):4814-4827  PubMed ID: 31431463
11505  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217
6953  Imaeda A, Tomoike F, Hayakawa M, Nakamoto K, Kimura Y, Abe N, Abe H.  N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity.  Nucleosides Nucleotides Nucleic Acids  2019  38(12):972-979  PubMed ID: 31298608
12144  Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A.  Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma  Cell Rep  2019  2274-2281.e5  PubMed ID: 30811978
12593  Qiu W, Song S, Chen W, Zhang J, Yang H, Chen Y.  Hypoxia-induced EPHB2 promotes invasive potential of glioblastoma  Int J Clin Exp Pathol  2019  12(2):539-548  PubMed ID: 31933858
4353  Peng F, Wang X, Shu M, Yang M, Wang L, Ouyang Z, Shen C, Hou X, Zhao B, Wang X, Zhang LW, Liu Y, Zhao S.  Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis.  Cell. Physiol. Biochem.  2018  47(3):1108-1121  PubMed ID: 29843152
4375  Fukushima T, Kawaguchi M, Yamamoto K, Yamashita F, Izumi A, Kaieda T, Takezaki Y, Itoh H, Takeshima H, Kataoka H.  Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas.  Cancer Sci.  2018  109(9):2970-2979  PubMed ID: 29987920
4503  Ishiguro Y, Kobayashi M, Ideno M, Narumi K, Furugen A, Iseki K.  Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity.  Int J Pharm  2018  551(1-2):97-102  PubMed ID: 30138705
10052  Shinoda Y, Takahashi T, Akimoto J, Ichikawa M, Yamazaki H, Narumi A, Yano S, Fujiwara Y.  Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.  J Toxicol Sci  2017  42:111-119  PubMed ID: 28070104
10523  Asano M, Tanaka S, Sakaguchi M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K.  Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis.  Sci Rep  2017  7:11406  PubMed ID: 28900243
10559  Goji T, Takahara K, Negishi M, Katoh H.  Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation.  J. Biol. Chem.  2017  292:19721-19732  PubMed ID: 29038291
7299  Miki Y, Akimoto J, Moritake K, Hironaka C, Fujiwara Y.  Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells.  Lasers Med Sci  2015  30:1739-45  PubMed ID: 26109138
7547  Miki Y., Akimoto J., Sato A., Fujiwara Y.  Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death.  Fundamental Toxicological Sciences  2015  2:111-116 
7557  Seki K, Kinashi Y, Takahashi S.  Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma.  Anticancer Res.  2015  35:169-74  PubMed ID: 25550548
13710  Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H.  Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-κB, on glioblastoma  Neuro Oncol  2012  14(1):19-28  PubMed ID: 21968049
6312  Ohsaka, Y. & Nishino, H.  Normal Japanese individuals harbor polymorphisms in the p14 ARF /INK4 locus promoters and/or other gene introns. — Variation in nucleotide sequences in each individual  Genes Genom  2011  33: 621 
7905  Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C.  MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.  Cell Death Dis  2010  1:e60  PubMed ID: 21364665
8109  Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H.  Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.  Biochem. Genet.  2010  48:970-86  PubMed ID: 20862607
3698  Fukushima T, Tezuka T, Shimomura T, Nakano S, Kataoka H.  Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24.  J Biol Chem  2007  282(25):18634-44  PubMed ID: 17475624

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