戻る 戻る
細胞番号 : 細胞名
RCB1954 : T98G  update : 2023/02/09
細胞特性(Comment:英)Human cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト glioblastoma multiforme (Caucasian)由来細胞株. Hyperpentaploid chromosome count。 TKG0471 (東北大学医用細胞資源センターからの寄託)。
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
寄託日 2004
元の細胞 TKG0471
動物種 human < Mammals
属名 Homo
種名 sapiens
性別 Male
61 years
採取組織 brain
病名 glioblastoma multiforme tumor
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0471)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0556
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP
個体識別検査 OK
文献情報 Reference(英) 2件
Reference(日) 0件
利用者成果(英) 42件
利用者成果(日) 0件

4618  Stein GH, Yanishevsky RM.  Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons.  Proc Natl Acad Sci U S A  1981  78(5):3025-9  PubMed ID: 6265932   DOI: 10.1073/pnas.78.5.3025
3267  Stein, G H  T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro.  J Cell Physiol  1979  99:43-54  PubMed ID: 222778   DOI: 10.1002/jcp.1040990107


21090  Li Y, Matsumoto Y, Chen L, Sugawara Y, Oe E, Fujisawa N, Ebara M, Sakurai H.  Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma.  Nanomaterials (Basel)  2023  13(3)  PubMed ID: 36770373   DOI: 10.3390/nano13030414
17698  Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe  Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i>  Advances in Microbiology  2022  12:649-670    DOI: 10.4236/aim.2022.1212045
20564  Hayashima K, Katoh H.  Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis.  J Biol Chem  2022  101703  PubMed ID: 35148992   DOI: 10.1016/j.jbc.2022.101703
20607  Shinohara Y, Ando H, Maekawa M, Arai M, Horibata Y, Satou M, Jojima T, Usui I, Aso Y, Sugimoto H.  Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS.  Biochim Biophys Acta Mol Cell Biol Lipids  2022  1867(6):159136  PubMed ID: 35306146   DOI: 10.1016/j.bbalip.2022.159136
20874  Mitobe Y, Nakagawa-Saito Y, Togashi K, Suzuki S, Sugai A, Matsuda KI, Sonoda Y, Kitanaka C, Okada M.  CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells.  Anticancer Res  2022  42(10):4727-4733  PubMed ID: 36192008   DOI: 10.21873/anticanres.15977
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
13413  Hayashima K, Kimura I, Katoh H.  Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.  Biochem Biophys Res Commun  2021    PubMed ID: 33421769   DOI: 10.1016/j.bbrc.2020.12.075
12121  Yamaguchi I, Yoshimura SH, Katoh H.  High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).  J. Biol. Chem.  2020    PubMed ID: 32265299   DOI: 10.1074/jbc.RA119.012213
12999  Kinashi Y, Ikawa T, Takahashi S.  The combined effect of neutron irradiation and temozolomide on glioblastoma cell lines with different MGMT and P53 status.  Appl Radiat Isot  2020    PubMed ID: 32561044   DOI: 10.1016/j.apradiso.2020.109204
11419  Feng S, Cai X, Li Y, Jian X, Zhang L, Li B.  Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells.  J. Exp. Clin. Cancer Res.  2019    PubMed ID: 30728039   DOI: 10.1186/s13046-019-1070-x
4672  Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y.  Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.  Cancer Res  2019  79(19):4814-4827  PubMed ID: 31431463   DOI: 10.1158/0008-5472.CAN-19-1272
11505  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217   DOI: 10.1016/j.bbrep.2019.100632
6953  Imaeda A, Tomoike F, Hayakawa M, Nakamoto K, Kimura Y, Abe N, Abe H.  N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity.  Nucleosides Nucleotides Nucleic Acids  2019  38(12):972-979  PubMed ID: 31298608   DOI: 10.1080/15257770.2019.1641205
12144  Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A.  Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma  Cell Rep  2019  2274-2281.e5  PubMed ID: 30811978   DOI: 10.1016/j.celrep.2019.01.109
12593  Qiu W, Song S, Chen W, Zhang J, Yang H, Chen Y.  Hypoxia-induced EPHB2 promotes invasive potential of glioblastoma  Int J Clin Exp Pathol  2019  12(2):539-548  PubMed ID: 31933858  
14811  Fan L, Chen Z, Wu X, Cai X, Feng S, Lu J, Wang H, Liu N.  Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail  Mol Cancer Res  2019  17(10):1975-1984  PubMed ID: 31266817   DOI: 10.1158/1541-7786.MCR-19-0197
4353  Peng F, Wang X, Shu M, Yang M, Wang L, Ouyang Z, Shen C, Hou X, Zhao B, Wang X, Zhang LW, Liu Y, Zhao S.  Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis.  Cell. Physiol. Biochem.  2018  47(3):1108-1121  PubMed ID: 29843152   DOI: 10.1159/000490187
4375  Fukushima T, Kawaguchi M, Yamamoto K, Yamashita F, Izumi A, Kaieda T, Takezaki Y, Itoh H, Takeshima H, Kataoka H.  Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas.  Cancer Sci.  2018  109(9):2970-2979  PubMed ID: 29987920   DOI: 10.1111/cas.13732
4503  Ishiguro Y, Kobayashi M, Ideno M, Narumi K, Furugen A, Iseki K.  Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity.  Int J Pharm  2018  551(1-2):97-102  PubMed ID: 30138705   DOI: 10.1016/j.ijpharm.2018.08.039
14903  Zhao B, Shen C, Zheng Z, Wang X, Zhao W, Chen X, Peng F, Xue L, Shu M, Hou X, Wang K, Zhong C, Sun J, Wan J, Zhao S.  Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking  Cell Physiol Biochem  2018  51(4):1566-1583  PubMed ID: 30497066   DOI: 10.1159/000495646
10052  Shinoda Y, Takahashi T, Akimoto J, Ichikawa M, Yamazaki H, Narumi A, Yano S, Fujiwara Y.  Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.  J Toxicol Sci  2017  42:111-119  PubMed ID: 28070104   DOI: 10.2131/jts.42.111
10523  Asano M, Tanaka S, Sakaguchi M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K.  Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis.  Sci Rep  2017  7:11406  PubMed ID: 28900243   DOI: 10.1038/s41598-017-11784-y
10559  Goji T, Takahara K, Negishi M, Katoh H.  Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation.  J. Biol. Chem.  2017  292:19721-19732  PubMed ID: 29038291   DOI: 10.1074/jbc.M117.814392
5680  Ginting TE, Suryatenggara J, Christian S, Mathew G.  Proinflammatory response induced by Newcastle disease virus in tumor and normal cells.  Oncolytic Virother  2017  6:21-30  PubMed ID: 28293547   DOI: 10.2147/OV.S123292
14208  Miyata K, Takemoto A, Okumura S, Nishio M, Fujita N.  Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation  Sci Rep  2017  7(1):4059  PubMed ID: 28642617   DOI: 10.1038/s41598-017-04324-1
7299  Miki Y, Akimoto J, Moritake K, Hironaka C, Fujiwara Y.  Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells.  Lasers Med Sci  2015  30:1739-45  PubMed ID: 26109138   DOI: 10.1007/s10103-015-1783-9
7547  Miki Y., Akimoto J., Sato A., Fujiwara Y.  Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death.  Fundamental Toxicological Sciences  2015  2:111-116    DOI: 10.2131/fts.2.111
7557  Seki K, Kinashi Y, Takahashi S.  Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma.  Anticancer Res.  2015  35:169-74  PubMed ID: 25550548  
15122  Liu H, Li C, Shen C, Yin F, Wang K, Liu Y, Zheng B, Zhang W, Hou X, Chen X, Wu J, Wang X, Zhong C, Zhang J, Shi H, Ai J, Zhao S.  MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3  J Neurooncol  2015  122(3):431-9  PubMed ID: 25720694   DOI: 10.1007/s11060-015-1736-y
15156  Hirohara S, Oka C, Totani M, Obata M, Yuasa J, Ito H, Tamura M, Matsui H, Kakiuchi K, Kawai T, Kawaichi M, Tanihara M.  Synthesis, Photophysical Properties, and Biological Evaluation of trans-Bisthioglycosylated Tetrakis(fluorophenyl)chlorin for Photodynamic Therapy  J Med Chem  2015  58(21):8658-70  PubMed ID: 26457363   DOI: 10.1021/acs.jmedchem.5b01262
15102  Sasaki S, Futagi Y, Kobayashi M, Ogura J, Iseki K.  Functional characterization of 5-oxoproline transport via SLC16A1/MCT1  J Biol Chem  2015  290(4):2303-11  PubMed ID: 25371203   DOI: 10.1074/jbc.M114.581892
17085  Kinashi Y, Okumura K, Kubota Y, Kitajima E, Okayasu R, Ono K, Takahashi S.  Dose-rate effect was observed in T98G glioma cells following BNCT  Appl Radiat Isot  2014  88:81-5  PubMed ID: 24360864   DOI: 10.1016/j.apradiso.2013.11.117
13710  Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H.  Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-κB, on glioblastoma  Neuro Oncol  2012  14(1):19-28  PubMed ID: 21968049   DOI: 10.1093/neuonc/nor168
15728  Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C.  Targeting JNK for therapeutic depletion of stem-like glioblastoma cells  Sci Rep  2012  2:516  PubMed ID: 22816039   DOI: 10.1038/srep00516
6312  Ohsaka, Y. & Nishino, H.  Normal Japanese individuals harbor polymorphisms in the p14 ARF /INK4 locus promoters and/or other gene introns. — Variation in nucleotide sequences in each individual  Genes Genom  2011  33: 621    DOI: 10.1007/s13258-011-0085-2
7797  Ohsaka Y, Nishino H.  Polymorphisms in promoter sequences of MDM2, p53, and p16 genes in normal Japanese individuals.  Genet. Mol. Biol.  2010  33:615-26  PubMed ID: 21637567   DOI: 10.1590/s1415-47572010000400004
7905  Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C.  MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.  Cell Death Dis  2010  1:e60  PubMed ID: 21364665   DOI: 10.1038/cddis.2010.37
8109  Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H.  Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.  Biochem. Genet.  2010  48:970-86  PubMed ID: 20862607   DOI: 10.1007/s10528-010-9379-3
16551  Song X, Chen Z, Wu C, Zhao S.  Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines  Can J Neurol Sci  2010  37(4):504-11  PubMed ID: 20724260   DOI: 10.1017/s0317167100010544
3698  Fukushima T, Tezuka T, Shimomura T, Nakano S, Kataoka H.  Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24.  J Biol Chem  2007  282(25):18634-44  PubMed ID: 17475624   DOI: 10.1074/jbc.M609567200
14417  Sano M, Genkai N, Yajima N, Tsuchiya N, Homma J, Tanaka R, Miki T, Yamanaka R.  Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients  Oncol Rep  2006  16(5):1093-8  PubMed ID: 17016598  
14418  Homma J, Yamanaka R, Yajima N, Tsuchiya N, Genkai N, Sano M, Tanaka R.  Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients  Oncol Rep  2006  15(3):595-601  PubMed ID: 16465418  


戻る 戻る 理研トップページへ