CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1954 : T98G]

4618 Stein GH, Yanishevsky RM. Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons. Proc Natl Acad Sci U S A 1981 78(5):3025-9 PubMed ID: 6265932 DOI: 10.1073/pnas.78.5.3025

3267 Stein, G H T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. J Cell Physiol 1979 99:43-54 PubMed ID: 222778 DOI: 10.1002/jcp.1040990107

Top

User's Publication

22921 Nakano H, Kidachi J, Imazato M, Kojima M, Tsutsumi K. The balance among radiation-induced cell death pathways in the p53-mutant human glioblastoma cell line T98G: A preliminary study. Biomed Res 2025 46(3):101-110 PubMed ID: 40436761 DOI: 10.2220/biomedres.46.101

19808 Yamaguchi I, Katoh H. Merlin/NF2 regulates SLC7A11/xCT expression and cell viability under glucose deprivation at high cell density in glioblastoma cells J Biochem 2024 175(3):313-322 PubMed ID: 38102738 DOI: 10.1093/jb/mvad105

19869 Morimoto T, Nakazawa T, Maeoka R, Matsuda R, Nakamura M, Nishimura F, Yamada S, Nakagawa I, Park YS, Tsujimura T. Bulk RNA sequencing reveals the comprehensive genetic characteristics of human cord blood-derived natural killer cells Regen Ther 2024 25:367-376 PubMed ID: 38405180 DOI: 10.1016/j.reth.2024.02.002

21603 Morimoto T, Nakazawa T, Matsuda R, Maeoka R, Nishimura F, Nakamura M, Yamada S, Park YS, Tsujimura T, Nakagawa I. Antitumor Effects of Intravenous Natural Killer Cell Infusion in an Orthotopic Glioblastoma Xenograft Murine Model and Gene Expression Profile Analysis. Int J Mol Sci 2024 25(4) PubMed ID: 38397112 DOI: 10.3390/ijms25042435

21638 Koh I, Hagiwara M. Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction. Commun Biol 2024 7(1):177 PubMed ID: 38418614 DOI: 10.1038/s42003-024-05857-8

21674 Kinoshita S, Ishii M, Ando J, Kimura T, Yamaguchi T, Harada S, Takahashi F, Nakashima K, Nakazawa Y, Yamazaki S, Ohshima K, Takahashi K, Nakauchi H, Ando M. Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer. Cancer Res Commun 2024 4(3):723-737 PubMed ID: 38380966 DOI: 10.1158/2767-9764.CRC-23-0259

22628 Nakazawa T, Morimoto T, Maeoka R, Yamada K, Matsuda R, Nakamura M, Nishimura F, Yamada S, Park YS, Tsujimura T, Nakagawa I. Characterization of HIF-1α Knockout Primary Human Natural Killer Cells Including Populations in Allogeneic Glioblastoma Int J Mol Sci 2024 25(11):5896 PubMed ID: 38892084 DOI: 10.3390/ijms25115896

22855 Tsutsumi K, Tippayamontri T, Hayashi M, Matsuda N, Goto Y. The dynamic relationship between inorganic polyphosphate and adenosine triphosphate in human non-small cell lung cancer H1299 cells FEBS Open Bio 2024 14(2):344-354 PubMed ID: 38105501 DOI: 10.1002/2211-5463.13753

19592 Maeoka R, Nakazawa T, Matsuda R, Morimoto T, Shida Y, Yamada S, Nishimura F, Nakamura M, Nakagawa I, Park YS, Tsujimura T, Nakase H. Therapeutic Anti-KIR Antibody of 1-7F9 Attenuates the Antitumor Effects of Expanded and Activated Human Primary Natural Killer Cells on In Vitro Glioblastoma-like Cells and Orthotopic Tumors Derived Therefrom Int J Mol Sci 2023 24(18):14183 PubMed ID: 37762486 DOI: 10.3390/ijms241814183

19770 Mitobe Y, Suzuki S, Nakagawa-Saito Y, Togashi K, Sugai A, Sonoda Y, Kitanaka C, Okada M. Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells Cancers (Basel) 2023 15(17):4326 PubMed ID: 37686602 DOI: 10.3390/cancers15174326

19946 Nakazawa T, Maeoka R, Morimoto T, Matsuda R, Nakamura M, Nishimura F, Yamada S, Nakagawa I, Park YS, Ito T, Nakase H, Tsujimura T. An efficient feeder-free and chemically-defined expansion strategy for highly purified natural killer cells derived from human cord blood Regen Ther 2023 24:32-42 PubMed ID: 37303464 DOI: 10.1016/j.reth.2023.05.006

19953 Nakazawa T, Morimoto T, Maeoka R, Matsuda R, Nakamura M, Nishimura F, Ouji N, Yamada S, Nakagawa I, Park YS, Ito T, Nakase H, Tsujimura T. CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma J Exp Clin Cancer Res 2023 42(1):205 PubMed ID: 37563692 DOI: 10.1186/s13046-023-02770-6

21090 Li Y, Matsumoto Y, Chen L, Sugawara Y, Oe E, Fujisawa N, Ebara M, Sakurai H. Smart Nanofiber Mesh with Locally Sustained Drug Release Enabled Synergistic Combination Therapy for Glioblastoma. Nanomaterials (Basel) 2023 13(3) PubMed ID: 36770373 DOI: 10.3390/nano13030414

21373 Suzuki MM, Iijima K, Ogami K, Shinjo K, Murofushi Y, Xie J, Wang X, Kitano Y, Mamiya A, Kibe Y, Nishimura T, Ohka F, Saito R, Sato S, Kobayashi J, Yao R, Miyata K, Kataoka K, Suzuki HI, Kondo Y. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation. Nat Commun 2023 14(1):4521 PubMed ID: 37607907 DOI: 10.1038/s41467-023-40243-8

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

17698 Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i> Advances in Microbiology 2022 12:649-670 DOI: 10.4236/aim.2022.1212045

20564 Hayashima K, Katoh H. Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis. J Biol Chem 2022 101703 PubMed ID: 35148992 DOI: 10.1016/j.jbc.2022.101703

20607 Shinohara Y, Ando H, Maekawa M, Arai M, Horibata Y, Satou M, Jojima T, Usui I, Aso Y, Sugimoto H. Transcription of cytochrome P450 46A1 in NIH3T3 cells is negatively regulated by FBS. Biochim Biophys Acta Mol Cell Biol Lipids 2022 1867(6):159136 PubMed ID: 35306146 DOI: 10.1016/j.bbalip.2022.159136

20874 Mitobe Y, Nakagawa-Saito Y, Togashi K, Suzuki S, Sugai A, Matsuda KI, Sonoda Y, Kitanaka C, Okada M. CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells. Anticancer Res 2022 42(10):4727-4733 PubMed ID: 36192008 DOI: 10.21873/anticanres.15977

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

13413 Hayashima K, Kimura I, Katoh H. Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells. Biochem Biophys Res Commun 2021 PubMed ID: 33421769 DOI: 10.1016/j.bbrc.2020.12.075

12121 Yamaguchi I, Yoshimura SH, Katoh H. High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11). J. Biol. Chem. 2020 PubMed ID: 32265299 DOI: 10.1074/jbc.RA119.012213

12999 Kinashi Y, Ikawa T, Takahashi S. The combined effect of neutron irradiation and temozolomide on glioblastoma cell lines with different MGMT and P53 status. Appl Radiat Isot 2020 PubMed ID: 32561044 DOI: 10.1016/j.apradiso.2020.109204

11419 Feng S, Cai X, Li Y, Jian X, Zhang L, Li B. Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells. J. Exp. Clin. Cancer Res. 2019 PubMed ID: 30728039 DOI: 10.1186/s13046-019-1070-x

4672 Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas. Cancer Res 2019 79(19):4814-4827 PubMed ID: 31431463 DOI: 10.1158/0008-5472.CAN-19-1272

11505 Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K. Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression. Biochem Biophys Rep 2019 18:100632 PubMed ID: 30993217 DOI: 10.1016/j.bbrep.2019.100632

6953 Imaeda A, Tomoike F, Hayakawa M, Nakamoto K, Kimura Y, Abe N, Abe H. N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity. Nucleosides Nucleotides Nucleic Acids 2019 38(12):972-979 PubMed ID: 31298608 DOI: 10.1080/15257770.2019.1641205

12144 Ranjit M, Hirano M, Aoki K, Okuno Y, Ohka F, Yamamichi A, Kato A, Maeda S, Motomura K, Matsuo K, Enomoto A, Ino Y, Todo T, Takahashi M, Wakabayashi T, Kato T, Natsume A. Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma Cell Rep 2019 2274-2281.e5 PubMed ID: 30811978 DOI: 10.1016/j.celrep.2019.01.109

12593 Qiu W, Song S, Chen W, Zhang J, Yang H, Chen Y. Hypoxia-induced EPHB2 promotes invasive potential of glioblastoma Int J Clin Exp Pathol 2019 12(2):539-548 PubMed ID: 31933858

14811 Fan L, Chen Z, Wu X, Cai X, Feng S, Lu J, Wang H, Liu N. Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail Mol Cancer Res 2019 17(10):1975-1984 PubMed ID: 31266817 DOI: 10.1158/1541-7786.MCR-19-0197

4353 Peng F, Wang X, Shu M, Yang M, Wang L, Ouyang Z, Shen C, Hou X, Zhao B, Wang X, Zhang LW, Liu Y, Zhao S. Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis. Cell. Physiol. Biochem. 2018 47(3):1108-1121 PubMed ID: 29843152 DOI: 10.1159/000490187

4375 Fukushima T, Kawaguchi M, Yamamoto K, Yamashita F, Izumi A, Kaieda T, Takezaki Y, Itoh H, Takeshima H, Kataoka H. Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas. Cancer Sci. 2018 109(9):2970-2979 PubMed ID: 29987920 DOI: 10.1111/cas.13732

4503 Ishiguro Y, Kobayashi M, Ideno M, Narumi K, Furugen A, Iseki K. Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity. Int J Pharm 2018 551(1-2):97-102 PubMed ID: 30138705 DOI: 10.1016/j.ijpharm.2018.08.039

14903 Zhao B, Shen C, Zheng Z, Wang X, Zhao W, Chen X, Peng F, Xue L, Shu M, Hou X, Wang K, Zhong C, Sun J, Wan J, Zhao S. Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking Cell Physiol Biochem 2018 51(4):1566-1583 PubMed ID: 30497066 DOI: 10.1159/000495646

10052 Shinoda Y, Takahashi T, Akimoto J, Ichikawa M, Yamazaki H, Narumi A, Yano S, Fujiwara Y. Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells. J Toxicol Sci 2017 42:111-119 PubMed ID: 28070104 DOI: 10.2131/jts.42.111

10112 Asano M, Sakaguchi M, Tanaka S, Kashimura K, Mitani T, Kawase M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K. Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator. Sci Rep 2017 7:41244 PubMed ID: 28145466 DOI: 10.1038/srep41244

10523 Asano M, Tanaka S, Sakaguchi M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K. Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis. Sci Rep 2017 7:11406 PubMed ID: 28900243 DOI: 10.1038/s41598-017-11784-y

10559 Goji T, Takahara K, Negishi M, Katoh H. Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation. J. Biol. Chem. 2017 292:19721-19732 PubMed ID: 29038291 DOI: 10.1074/jbc.M117.814392

5680 Ginting TE, Suryatenggara J, Christian S, Mathew G. Proinflammatory response induced by Newcastle disease virus in tumor and normal cells. Oncolytic Virother 2017 6:21-30 PubMed ID: 28293547 DOI: 10.2147/OV.S123292

14208 Miyata K, Takemoto A, Okumura S, Nishio M, Fujita N. Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation Sci Rep 2017 7(1):4059 PubMed ID: 28642617 DOI: 10.1038/s41598-017-04324-1

18189 Peng C, Chen Z, Wang S, Wang HW, Qiu W, Zhao L, Xu R, Luo H, Chen Y, Chen D, You Y, Liu N, Wang H. The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling Cancer Res 2016 76(8):2340-53 PubMed ID: 26960975 DOI: 10.1158/0008-5472.CAN-15-1884

7299 Miki Y, Akimoto J, Moritake K, Hironaka C, Fujiwara Y. Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells. Lasers Med Sci 2015 30:1739-45 PubMed ID: 26109138 DOI: 10.1007/s10103-015-1783-9

7547 Miki Y., Akimoto J., Sato A., Fujiwara Y. Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death. Fundamental Toxicological Sciences 2015 2:111-116 DOI: 10.2131/fts.2.111

7557 Seki K, Kinashi Y, Takahashi S. Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma. Anticancer Res. 2015 35:169-74 PubMed ID: 25550548

15122 Liu H, Li C, Shen C, Yin F, Wang K, Liu Y, Zheng B, Zhang W, Hou X, Chen X, Wu J, Wang X, Zhong C, Zhang J, Shi H, Ai J, Zhao S. MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3 J Neurooncol 2015 122(3):431-9 PubMed ID: 25720694 DOI: 10.1007/s11060-015-1736-y

15156 Hirohara S, Oka C, Totani M, Obata M, Yuasa J, Ito H, Tamura M, Matsui H, Kakiuchi K, Kawai T, Kawaichi M, Tanihara M. Synthesis, Photophysical Properties, and Biological Evaluation of trans-Bisthioglycosylated Tetrakis(fluorophenyl)chlorin for Photodynamic Therapy J Med Chem 2015 58(21):8658-70 PubMed ID: 26457363 DOI: 10.1021/acs.jmedchem.5b01262

15102 Sasaki S, Futagi Y, Kobayashi M, Ogura J, Iseki K. Functional characterization of 5-oxoproline transport via SLC16A1/MCT1 J Biol Chem 2015 290(4):2303-11 PubMed ID: 25371203 DOI: 10.1074/jbc.M114.581892

17085 Kinashi Y, Okumura K, Kubota Y, Kitajima E, Okayasu R, Ono K, Takahashi S. Dose-rate effect was observed in T98G glioma cells following BNCT Appl Radiat Isot 2014 88:81-5 PubMed ID: 24360864 DOI: 10.1016/j.apradiso.2013.11.117

19076 Zhao SG, Chen XF, Wang LG, Yang G, Han DY, Teng L, Yang MC, Wang DY, Shi C, Liu YH, Zheng BJ, Shi CB, Gao X, Rainov NG. Increased expression of ABCB6 enhances protoporphyrin IX accumulation and photodynamic effect in human glioma Ann Surg Oncol 2013 20(13):4379-88 PubMed ID: 22688660 DOI: 10.1245/s10434-011-2201-6

13710 Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H. Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor-κB, on glioblastoma Neuro Oncol 2012 14(1):19-28 PubMed ID: 21968049 DOI: 10.1093/neuonc/nor168

15728 Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C. Targeting JNK for therapeutic depletion of stem-like glioblastoma cells Sci Rep 2012 2:516 PubMed ID: 22816039 DOI: 10.1038/srep00516

6312 Ohsaka, Y. & Nishino, H. Normal Japanese individuals harbor polymorphisms in the p14 ARF /INK4 locus promoters and/or other gene introns. — Variation in nucleotide sequences in each individual Genes Genom 2011 33: 621 DOI: 10.1007/s13258-011-0085-2

7797 Ohsaka Y, Nishino H. Polymorphisms in promoter sequences of MDM2, p53, and p16 genes in normal Japanese individuals. Genet. Mol. Biol. 2010 33:615-26 PubMed ID: 21637567 DOI: 10.1590/s1415-47572010000400004

7905 Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C. MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death. Cell Death Dis 2010 1:e60 PubMed ID: 21364665 DOI: 10.1038/cddis.2010.37

8109 Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H. Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals. Biochem. Genet. 2010 48:970-86 PubMed ID: 20862607 DOI: 10.1007/s10528-010-9379-3

16551 Song X, Chen Z, Wu C, Zhao S. Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines Can J Neurol Sci 2010 37(4):504-11 PubMed ID: 20724260 DOI: 10.1017/s0317167100010544

18304 Zhao S, Zhang J, Zhang X, Dong X, Sun X. Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status Mol Biol Rep 2008 35(3):421-9 PubMed ID: 17530438 DOI: 10.1007/s11033-007-9102-6

3698 Fukushima T, Tezuka T, Shimomura T, Nakano S, Kataoka H. Silencing of insulin-like growth factor-binding protein-2 in human glioblastoma cells reduces both invasiveness and expression of progression-associated gene CD24. J Biol Chem 2007 282(25):18634-44 PubMed ID: 17475624 DOI: 10.1074/jbc.M609567200

18714 Genkai N, Homma J, Sano M, Tanaka R, Yamanaka R. Increased expression of pituitary tumor-transforming gene (PTTG)-1 is correlated with poor prognosis in glioma patients Oncol Rep 2006 15(6):1569-74 PubMed ID: 16685397

14417 Sano M, Genkai N, Yajima N, Tsuchiya N, Homma J, Tanaka R, Miki T, Yamanaka R. Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients Oncol Rep 2006 16(5):1093-8 PubMed ID: 17016598

14418 Homma J, Yamanaka R, Yajima N, Tsuchiya N, Genkai N, Sano M, Tanaka R. Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients Oncol Rep 2006 15(3):595-601 PubMed ID: 16465418