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Cell No. : Cell Name
RCB1951 : TE-15  update : 2021/05/20
CommentHuman cell line derived from esophageal cancer (highly differentiated squamous cell carcinoma). Not transplantable to nude mouse. TKG0266 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditions1) In publishing the research results to be obtained by use of this cell line, an acknowledgment to the Depositor, Dr. Tetsuro Nishihira is required. 2) There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Nishihira, Tetsuro (Akaishi, T.)
Year of deposit 2004
Original cell TKG0266
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Tissue esophagus
Disease name squamous carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0266)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1763
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Coating dish type I collagen coated dish
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 2
User's Publication 38


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Reference
3174  Hay, Park, Gazdar, Ed.    Atlas of Human Tumor Cell Lines  1994  269-282 
3173  Nishihira T, Hashimoto Y, Katayama M, Mori S, Kuroki T  Molecular and cellular features of esophageal cancer cells.  J Cancer Res Clin Oncol  1993  119:441-9  PubMed ID: 8509434

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User's Publication
20614  Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O.  Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer.  Biochem Biophys Rep  2022  30:101246  PubMed ID: 35330672
13104  Yoshida T, Yokobori T, Saito H, Kuriyama K, Kumakura Y, Honjo H, Hara K, Sakai M, Miyazaki T, Obinata H, Erkhem-Ochir B, Gombodorj N, Sohda M, Saeki H, Kuwano H, Shirabe K.  CD36 Expression Is Associated with Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 32529269
13383  Sakamoto H, Koma YI, Higashino N, Kodama T, Tanigawa K, Shimizu M, Fujikawa M, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.  Lab Invest  2021  101(3):353-368  PubMed ID: 33311557
20015  Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.  Am J Pathol  2021    PubMed ID: 33460563
20046  Mitsuda M, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33565032
16863  Takaki W, Konishi H, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Fujiwara H, Masuda K, Otsuji E.  Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2021  28(13):8508-8518  PubMed ID: 34185205
12107  Matsubara D, Konishi H, Arita T, Shoda K, Fujita Y, Ogino S, Takao K, Nanishi K, Kosuga T, Komatsu S, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E.  Involvement of Intracellular and Extracellular High-Mobility Group Box-1 in the Progression of Esophageal Squamous Cell Carcinoma.  Ann. Surg. Oncol.  2020    PubMed ID: 32221734
13045  Kodama T, Koma YI, Arai N, Kido A, Urakawa N, Nishio M, Shigeoka M, Yokozaki H.  CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways.  Lab Invest  2020    PubMed ID: 32457351
13609  Okamoto M, Koma YI, Kodama T, Nishio M, Shigeoka M, Yokozaki H.  Growth Differentiation Factor 15 Promotes Progression of Esophageal Squamous Cell Carcinoma via TGF-β Type II Receptor Activation  Pathobiology  2020  87(2):100-113  PubMed ID: 31896114
11432  Kodaira H, Koma YI, Hosono M, Higashino N, Suemune K, Nishio M, Shigeoka M, Yokozaki H.  ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma.  Pathol. Int.  2019    PubMed ID: 30758105
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826
11631  Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.  LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.  Am. J. Pathol.  2019    PubMed ID: 31323188
11809  Iwabu J, Yamashita S, Takeshima H, Kishino T, Takahashi T, Oda I, Koyanagi K, Igaki H, Tachimori Y, Daiko H, Nakazato H, Nishiyama K, Lee YC, Hanazaki K, Ushijima T.  FGF5 methylation is a sensitivity marker of esophageal squamous cell carcinoma to definitive chemoradiotherapy.  Sci Rep  2019    PubMed ID: 31527639
11897  Su D, Zhang D, Jin J, Ying L, Han M, Chen K, Li B, Wu J, Xie Z, Zhang F, Lin Y, Cheng G, Li JY, Huang M, Wang J, Wang K, Zhang J, Li F, Xiong L, Futreal A, Mao W.  Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.  Nat Commun  2019    PubMed ID: 31700061
11699  Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ogata Y, Eto K, Hiyoshi Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer.  Cancer Sci  2019  110(6):1863-1871  PubMed ID: 31012515
12594  Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer  Cancer Sci  2019  110(12):3727-3737  PubMed ID: 31599475
10141  Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.  Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.  Int. J. Cancer  2017  140:2608-2621  PubMed ID: 28233302
10353  Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma.  Tumour Biol.  2017  39:1010428317700409  PubMed ID: 28618928
10692  Hosono M, Koma YI, Takase N, Urakawa N, Higashino N, Suemune K, Kodaira H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells.  Oncotarget  2017  8:106071-106088  PubMed ID: 29285315
14243  Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.  Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma  Oncotarget  2017  8(11):17921-17935  PubMed ID: 28160546
14585  Kikuchi M, Katoh H, Waraya M, Tanaka Y, Ishii S, Tanaka T, Nishizawa N, Yokoi K, Minatani N, Ema A, Kosaka Y, Tanino H, Yamashita K, Watanabe M.  Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer  Cancer Lett  2017  384:70-78  PubMed ID: 27756570
14654  Hadisaputri YE, Miyazaki T, Yokobori T, Sohda M, Sakai M, Ozawa D, Hara K, Honjo H, Kumakura Y, Kuwano H.  TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma  Int J Oncol  2017  50(3):1002-1010  PubMed ID: 28197630
9724  Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.  Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.  Br. J. Cancer  2016  115:66-75  PubMed ID: 27310703
12618  Kosumi K, Baba Y, Sakamoto A, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H.  Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer  Int J Cancer  2016  138(2):428-39  PubMed ID: 26240060
12903  Nishio M, Urakawa N, Shigeoka M, Takase N, Ichihara Y, Arai N, Koma Y, Yokozaki H.  Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma  Pathol Int  2016  66(2):83-93  PubMed ID: 26778807
12969  Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I.  Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma  Oncotarget  2016  7(13):17111-28  PubMed ID: 26958940
13973  Takase N, Koma Y, Urakawa N, Nishio M, Arai N, Akiyama H, Shigeoka M, Kakeji Y, Yokozaki H.  NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells  Cancer Lett  2016  380(1):47-58  PubMed ID: 27317650
13992  Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H.  UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma  Oncotarget  2016  7(36):57821-5783  PubMed ID: 27507047
14119  Park M, Yoon HJ, Kang MC, Kwon J, Lee HW.  PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma  Tumour Biol  2016  37(10):14217-14224  PubMed ID: 27557627
7382  Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T.  The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.  BMC Cancer  2015  15:82  PubMed ID: 25884729
15151  Yokobori T, Bao P, Fukuchi M, Altan B, Ozawa D, Rokudai S, Bai T, Kumakura Y, Honjo H, Hara K, Sakai M, Sohda M, Miyazaki T, Ide M, Nishiyama M, Oyama T, Kuwano H.  Nuclear PROX1 is Associated with Hypoxia-Inducible Factor 1α Expression and Cancer Progression in Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2015  22 Suppl 3:S1566-73  PubMed ID: 26310281
15184  Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.  Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom  Anticancer Res  2015  35(9):4617-24  PubMed ID: 26254350
15229  Shigeoka M, Urakawa N, Nishio M, Takase N, Utsunomiya S, Akiyama H, Kakeji Y, Komori T, Koma Y, Yokozaki H.  Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma  Cancer Med  2015  4(3):437-46  PubMed ID: 25620088
15232  Urakawa N, Utsunomiya S, Nishio M, Shigeoka M, Takase N, Arai N, Kakeji Y, Koma Y, Yokozaki H.  GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways  Lab Invest  2015  95(5):491-503  PubMed ID: 25730371
13765  Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H.  Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer  Cancer Res  2014  74(2):575-85  PubMed ID: 24272485
5026  Waraya M, Yamashita K, Katoh H, Ooki A, Kawamata H, Nishimiya H, Nakamura K, Ema A, Watanabe M.  Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis.  BMC Cancer  2012  12:397  PubMed ID: 22958219
8430  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.  Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.  Int. J. Cancer  2010  127:543-54  PubMed ID: 19960436
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309



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