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Cell No. : Cell Name
RCB1947 : Ca Ski  update : 2024/06/12
CommentHuman cell line derived from uterine cervical epidermoid carcinoma. TKG0366 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Obinata, Masuo
Originator Pattillo, R. A.
Year of deposit 2004
Original cell TKG0366
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 40 years
Tissue cervix
Disease name epidermoid carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0366)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1100
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
deposit info
lot info
Reference information Reference 9
User's Publication 12

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3250  Kurban G, Ishiwata T, Lu, Y P, Fujii T, Kawahara K, Naito Z, Yamada N, Asano G  [Expression and intracytoplasmic signal transduction pathway of fibroblast growth factor (FGF)-10 in human cervical cancer cell lines]  J Nippon Med Sch  2001  68:253-8  PubMed ID: 11404772   DOI: 10.1272/jnms.68.253
3256  Hendricks, D T, Taylor R, Reed M, Birrer, M J  FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines.  Cancer Res  1997  57:2112-5  PubMed ID: 9187105  
3249  Baker, C C, Phelps, W C, Lindgren V, Braun, M J, Gonda, M A, Howley, P M  Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines.  J Virol  1987  61:962-71  PubMed ID: 3029430   DOI: 10.1128/JVI.61.4.962-971.1987
5053  Hussa RO, Pattillo RA, Ruckert AC, Rinke ML, Cortesi JP, Fein HG.  Optimization of the production of hCG beta-like material by CaSki human cervical carcinoma cells in roller bottle culture.  Oncology  1986  43(1):54-9  PubMed ID: 3753621   DOI: 10.1159/000226105
5054  Hussa RO, Fein HG, Pattillo RA, Nagelberg SB, Rosen SW, Weintraub BD, Perini F, Ruddon RW, Cole LA.  A distinctive form of human chorionic gonadotropin beta-subunit-like material produced by cervical carcinoma cells.  Cancer Res  1986  46(4 Pt 2):1948-54  PubMed ID: 2418956  
5055  Hussa RO, Maruo T, Strobel JL, Pattillo RA, Mochizuki M.  Production of tumor-associated antigen, TA-4, by the CaSki cervical carcinoma cell line.  Obstet Gynecol  1986  67(6):802-5  PubMed ID: 2422615   DOI: 10.1097/00006250-198606000-00010
3255  Yee C, Krishnan-Hewlett I, Baker, C C, Schlegel R, Howley, P M  Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.  Am J Pathol  1985  119:361-6  PubMed ID: 2990217  
3254  Pater, M M, Pater A  Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix.  Virology  1985  145:313-8  PubMed ID: 2992153   DOI: 10.1016/0042-6822(85)90164-3
3253  Pattillo, R A, Hussa, R O, Story, M T, Ruckert, A C, Shalaby, M R, Mattingly, R F  Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line.  Science  1977  196:1456-8  PubMed ID: 867042   DOI: 10.1126/science.867042

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User's Publication
19540  Furukawa Y, Ishii M, Ando J, Ikeda K, Igarashi KJ, Kinoshita S, Azusawa Y, Toyota T, Honda T, Nakanishi M, Ohshima K, Masuda A, Yoshida E, Kitade M, Porteus M, Terao Y, Nakauchi H, Ando M.  iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer  Cell Rep Med  2023  4(12):101327  PubMed ID: 38091985   DOI: 10.1016/j.xcrm.2023.101327
18210  Krishnamurthy S, Yoda H, Hiraoka K, Inoue T, Lin J, Shinozaki Y, Watanabe T, Koshikawa N, Takatori A, Nagase H.  Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer  Cancer Sci  2021  112(3):1141-1149  PubMed ID: 33377228   DOI: 10.1111/cas.14785
13328  Kagabu M, Yoshino N, Saito T, Miura Y, Takeshita R, Murakami K, Kawamura H, Baba T, Sugiyama T.  The efficacy of a third-generation oncolytic herpes simplex viral therapy for an HPV-related uterine cervical cancer model.  Int J Clin Oncol  2021  26(3):591-597.  PubMed ID: 33146805   DOI: 10.1007/s10147-020-01823-6
20249  Makise M, Uchimura R, Higashi K, Mashiki Y, Shiraishi R, Shutoku Y, Kuniyasu A.  Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells.  Histochem Cell Biol  2021    PubMed ID: 34331103   DOI: 10.1007/s00418-021-02020-w
20389  D S P, Chaturvedi PK, Shimokawa T, Kim KH, Park WY.  Silencing of Fused Toes Homolog (FTS) Increases Radiosensitivity to Carbon-Ion Through Downregulation of Notch Signaling in Cervical Cancer Cells.  Front Oncol  2021  11:730607  PubMed ID: 34765546   DOI: 10.3389/fonc.2021.730607
4371  Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Yonese J, Yuasa T.  Abundance of TRAIL attenuated by HIF2α and c-FLIP affects malignancy in renal cell carcinomas.  Oncotarget  2018  9(33):23091-23101  PubMed ID: 29796174   DOI: 10.18632/oncotarget.25214
14611  Ueda T, Tsubamoto H, Inoue K, Sakata K, Shibahara H, Sonoda T.  Itraconazole Modulates Hedgehog, WNT/β-catenin, as well as Akt Signalling, and Inhibits Proliferation of Cervical Cancer Cells  Anticancer Res  2017  3521-3526  PubMed ID: 28668841   DOI: 10.21873/anticanres.11720
5011  Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, Yamaguchi K, Abiko K, Koshiyama M, Mandai M, Murata T, Murphy SK, Konishi I.  Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.  Gynecol Oncol  2015  136(1):104-11  PubMed ID: 25434636   DOI: 10.1016/j.ygyno.2014.11.075
6096  Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A.  Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms.  Lab Invest  2012  92(5):688-702  PubMed ID: 22330335   DOI: 10.1038/labinvest.2012.9
7659  Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.  HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.  Cancer Res.  2011  71:6633-42  PubMed ID: 22009535   DOI: 10.1158/0008-5472.CAN-11-0034
8093  Matsuda Y, Fujii T, Suzuki T, Yamahatsu K, Kawahara K, Teduka K, Kawamoto Y, Yamamoto T, Ishiwata T, Naito Z.  Comparison of fixation methods for preservation of morphology, RNAs, and proteins from paraffin-embedded human cancer cell-implanted mouse models.  J. Histochem. Cytochem.  2011  59:68-75  PubMed ID: 20940453   DOI: 10.1369/jhc.2010.957217
3516  Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S.  Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines.  BMC Mol Biol  2011  12:31  PubMed ID: 21771320   DOI: 10.1186/1471-2199-12-31

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