CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1945 : HSC-2]

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19774 Kasamatsu A, Nozaki R, Kawasaki K, Saito T, Minemura C, Seki N, Moss J, Uzawa K. Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma Cancers (Basel) 2024 16(6):1242 PubMed ID: 38539573 DOI: 10.3390/cancers16061242

21577 Al Awadh AA, Sakagami H, Amano S, Sayed AM, Abouelela ME, Alhasaniah AH, Aldabaan N, Refaey MS, Abdelhamid RA, Khalil HMA, Hamdan DI, Abdel-Sattar ES, Orabi MAA. In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations. Front Pharmacol 2024 15:1325272 PubMed ID: 38303989 DOI: 10.3389/fphar.2024.1325272

21708 Inomata M, Abe M, Kawase Y, Hayashi T, Amano S, Sakagami H. Dectin-1/SYK Activation Induces Antimicrobial Peptide and Negative Regulator of NF-κB Signaling in Human Oral Epithelial Cells. In Vivo 2024 38(3):1042-1048 PubMed ID: 38688646 DOI: 10.21873/invivo.13537

21752 Yonesi A, Tomihara K, Takatsuka D, Tachinami H, Yamazaki M, Jadidi ARY, Takaichi M, Imaue S, Fujiwara K, Yamada SI, Tanuma JI, Noguchi M. Rapamycin Induces Phenotypic Alterations in Oral Cancer Cells That May Facilitate Antitumor T Cell Responses. Biomedicines 2024 12(5) PubMed ID: 38791040 DOI: 10.3390/biomedicines12051078

21807 Takatsuka D, Tachinami H, Suzuki N, Yamazaki M, Yonesi A, Takaichi M, Imaue S, Yamada SI, Tanuma JI, Noguchi M, Tomihara K. PAK4 inhibition augments anti-tumour effect by immunomodulation in oral squamous cell carcinoma. Sci Rep 2024 14(1):14092 PubMed ID: 38890401 DOI: 10.1038/s41598-024-64126-0

21900 Mayuka Yamagata, Sen Higashi, Noboru Yaida, Akane Ichihara, Manabu Habu, Masaaki Sasaguri, Kazuhiro Tominaga, Hiroshi Takeuchi Enhanced degradation of epidermal growth factor receptor by metformin Oral Science International 2024 21:59-67 DOI: 10.1002/osi2.1179

22052 Abé T, Yamazaki M, Nozumi M, Maruyama S, Takamura K, Ohashi R, Ajioka Y, Tanuma JI. Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved in cell migration and epithelial phenotype. Sci Rep 2024 14(1):22778 PubMed ID: 39354061 DOI: 10.1038/s41598-024-74041-z

22313 Karki SS, Das U, Balzarini J, De Clercq E, Sakagami H, Uesawa Y, Roayapalley PK, Dimmock JR. Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones? Medicines (Basel) 2024 11(8) PubMed ID: 39584969 DOI: 10.3390/medicines11080019

19591 Kawasaki Y, Omori Y, Suzuki S, Yamada T. CD98hc as a marker of radiotherapy-resistant cancer stem cells in head and neck squamous cell carcinoma Arch Med Sci 2023 19(6):1859-1868 PubMed ID: 38058706 DOI: 10.5114/aoms.2020.92872

19748 Yamaki H, Kono M, Wakisaka R, Komatsuda H, Kumai T, Hayashi R, Sato R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Hayashi T, Kobayashi H, Katada A. Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer Cancer Immunol Immunother 2023 72(8):2799-2812 PubMed ID: 37173455 DOI: 10.1007/s00262-023-03460-0

19759 Takanori Takenawa, Koji Harada, Tarannum Ferdous, Keisuke Kawasaki, Yasuhiro Kuramitsu, Katsuaki Mishima Silencing of Tropomyosin 1 suppresses the proliferation, invasion and metastasis of oral squamous cell carcinoma in vitro Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023 35:282-287 DOI: 10.1016/j.ajoms.2022.10.004

19822 Nakashiro KI, Tokuzen N, Saika M, Shirai H, Kuribayashi N, Goda H, Uchida D. MicroRNA-1289 Functions as a Novel Tumor Suppressor in Oral Squamous Cell Carcinoma Cancers (Basel) 2023 15(16):4138 PubMed ID: 37627167 DOI: 10.3390/cancers15164138

19875 Abe T, Sakagami H, Amano S, Uota S, Bandow K, Uesawa Y, U S, Shibata H, Takemura Y, Kimura Y, Takao K, Sugita Y, Sato A, Tanuma SI, Takeshima H. A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs Medicines (Basel) 2023 10(7):43 PubMed ID: 37505064 DOI: 10.3390/medicines10070043

21184 Chan NN, Yamazaki M, Maruyama S, Abé T, Haga K, Kawaharada M, Izumi K, Kobayashi T, Tanuma JI. Cholesterol Is a Regulator of CAV1 Localization and Cell Migration in Oral Squamous Cell Carcinoma. Int J Mol Sci 2023 24(7) PubMed ID: 37047005 DOI: 10.3390/ijms24076035

21370 Yamada T, Yamamori Y, Matsuda N, Nagamune H, Ohkura K, Tomoyasu T, Tabata A. Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors. Sci Rep 2023 13(1):13720 PubMed ID: 37608082 DOI: 10.1038/s41598-023-40981-1

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

21527 Orabi MAA, Orabi EA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Sakagami H, Hatano T. New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines. Antioxidants (Basel) 2023 12(11) PubMed ID: 38001804 DOI: 10.3390/antiox12111951

20382 Fan M, Arai M, Tawada A, Chiba T, Fukushima R, Uzawa K, Shiiba M, Kato N, Tanzawa H, Takiguchi Y. Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers. Oncol Rep 2022 47(1) PubMed ID: 34738627 DOI: 10.3892/or.2021.8216

20513 Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y. Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma. Oncoimmunology 2022 11(1):2021619 PubMed ID: 35003900 DOI: 10.1080/2162402X.2021.2021619

20544 Matsuda R, Sakagami H, Amano S, Iijima Y, Sano M, Uesawa Y, Tamura N, Oishi Y, Takeshima H. Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid. Anticancer Res 2022 42(2):781-790 PubMed ID: 35093876 DOI: 10.21873/anticanres.15536

20559 Komatsu M, Saito K, Miyamoto I, Koike K, Iyoda M, Nakashima D, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis. Oncol Lett 2022 23(2):49 PubMed ID: 34992682 DOI: 10.3892/ol.2021.13167

16180 Katsuhiro Asaka, Akira Fukatsu, Chiaki Komine The Effectiveness of a Portable Fluorescence Spectrophotometer for Early Detection of Oral Cancer Open Journal of Stomatology 2022 12:30-31 DOI: 10.4236/ojst.2022.121003

16203 Sasabe E, Tomomura A, Liu H, Sento S, Kitamura N, Yamamoto T. Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis Cancer Sci 2022 113(2):609-621 PubMed ID: 34874595 DOI: 10.1111/cas.15225

20638 Shahbaz K, Asif JA, Liszen T, Nurul AA, Alam MK. Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line. Biomed Res Int 2022 2022:5792830 PubMed ID: 35233390 DOI: 10.1155/2022/5792830

20648 Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H. Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives. Int J Mol Sci 2022 23(5) PubMed ID: 35269748 DOI: 10.3390/ijms23052601

20658 Tabata A, Shirai R, Miki H, Nishikawa Y, Kashima T, Aoyama T, Murakami S, Azuma M, Tomoyasu T, Nagamune H. Hapten-labeled fusion-polymerase chain reaction of multiple marker genes for the application of immunochromatographic test. J Biosci Bioeng 2022 PubMed ID: 35450786 DOI: 10.1016/j.jbiosc.2022.03.006

20815 Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR. Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells. Medicines (Basel) 2022 9(6) PubMed ID: 35736248 DOI: 10.3390/medicines9060035

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20965 Morisaka H, Takaishi M, Akira S, Sano S. Keratinocyte Regnase-1, a down-regulator of skin inflammation, contributes to protection against tumor promotion by limiting COX-2 expression. J Invest Dermatol 2022 PubMed ID: 36470473 DOI: 10.1016/j.jid.2022.11.007

22986 Nakamura N, Fujihara H, Kawaguchi K, Yamada H, Nakayama R, Yasukawa M, Kishi Y, Hamada Y, Masutani M. Possible Action of Olaparib for Preventing Invasion of Oral Squamous Cell Carcinoma In Vitro and In Vivo Int J Mol Sci 2022 23(5):2527 PubMed ID: 35269669 DOI: 10.3390/ijms23052527

13361 Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T. Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines. Fitoterapia 2021 PubMed ID: 33246033 DOI: 10.1016/j.fitote.2020.104780

20020 Shishido K, Kuroishi T, Sugawara S. P2 purinergic receptor signaling and interleukin-1 synergistically induce interleukin-6 production in a human oral squamous carcinoma cell line. J Oral Biosci 2021 PubMed ID: 33497843 DOI: 10.1016/j.job.2021.01.004

13580 Matsumoto A, Tabata A, Ohkura K, Oda H, Kodama C, Ohkuni H, Takao A, Kikuchi K, Tomoyasu T, Nagamune H. Molecular characteristics of an adhesion molecule containing cholesterol-dependent cytolysin-motif produced by mitis group streptococci Microbiol Immunol 2021 65(2):61-75 PubMed ID: 33331679 DOI: 10.1111/1348-0421.12868

20085 Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H. Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Sci Rep 2021 11(1):5897 PubMed ID: 33723306 DOI: 10.1038/s41598-021-85242-1

13776 Hamilton KL, Sheehan SA, Retzbach EP, Timmerman CA, Gianneschi GB, Tempera PJ, Balachandran P, Goldberg GS. Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways J Cancer Res Clin Oncol 2021 147(2):445-457 PubMed ID: 33205348 DOI: 10.1007/s00432-020-03456-8

20350 Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI. Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression. Transl Oncol 2021 14(12):101236 PubMed ID: 34624685 DOI: 10.1016/j.tranon.2021.101236

15868 Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K. Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma Oncol Lett 2021 22(4):730 PubMed ID: 34429770 DOI: 10.3892/ol.2021.12991

20455 Harada K, Ferdous T, Mishima K. Efficacy of a Novel Oral Chemotherapeutic Agent, TAS-102, Against Human Oral Squamous Cell Carcinoma Cells. Anticancer Res 2021 41(12):6039-6049 PubMed ID: 34848458 DOI: 10.21873/anticanres.15423

16099 Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E. PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1 Int J Oncol 2021 58(6):29 PubMed ID: 33887877 DOI: 10.3892/ijo.2021.5209

16112 Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M. Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells Oral Surg Oral Med Oral Pathol Oral Radiol 2021 132(5):549-565 PubMed ID: 34518137 DOI: 10.1016/j.oooo.2021.04.006

16136 Harada K, Ferdous T, Watanabe K, Mizukami Y, Mishima K. Effects of an elemental diet, Elental®, may differ between healthy oral cells and oral cancer cells Oncol Rep 2021 45(2):738-751 PubMed ID: 33416174 DOI: 10.3892/or.2020.7896

16139 Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma Int J Mol Sci 2021 22(23):12684 PubMed ID: 34884487 DOI: 10.3390/ijms222312684

16174 Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U. Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts Molecules 2021 26(23):7132 PubMed ID: 34885719 DOI: 10.3390/molecules26237132

16195 Yamali C, Sakagami H, Uesawa Y, Kurosaki K, Satoh K, Masuda Y, Yokose S, Ece A, Bua S, Angeli A, Supuran CT, Gul HI. Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides Eur J Med Chem 2021 217:113351 PubMed ID: 33744685 DOI: 10.1016/j.ejmech.2021.113351

16196 Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S. Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue Medicines (Basel) 2021 8(7):33 PubMed ID: 34206186 DOI: 10.3390/medicines8070033

16200 Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR. Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring Medicines (Basel) 2021 8(12):78 PubMed ID: 34940290 DOI: 10.3390/medicines8120078

16206 Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma Int J Mol Sci 2021 22(18):9947 PubMed ID: 34576110 DOI: 10.3390/ijms22189947

16862 Kawasaki M, Sakabe T, Kodani I, Umekita Y. Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma Anticancer Res 2021 41(9):4563-4570 PubMed ID: 34475084 DOI: 10.21873/anticanres.15269

16975 Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K. Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Res 2021 41(4):1821-1830 PubMed ID: 33813387 DOI: 10.21873/anticanres.14948

11844 Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M. CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity. Oral Dis 2020 26(4):745-755 PubMed ID: 31603606 DOI: 10.1111/odi.13210

6954 Hayashi H, Chiba T, Mihara-Tomiyama N, Negishi T, Kodama Y, Sakashita H, Imai K. Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear localization in oral carcinoma cells and the proliferation inhibition. Biochem Biophys Res Commun 2020 522(3):799-804 PubMed ID: 31791579 DOI: 10.1016/j.bbrc.2019.11.171

11965 Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T. The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. Lab. Invest. 2020 PubMed ID: 31857698 DOI: 10.1038/s41374-019-0357-z

12037 Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H. Modification of TRPV4 activity by acetaminophen. Heliyon 2020 PubMed ID: 32051870 DOI: 10.1016/j.heliyon.2020.e03301

13013 Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H. Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation. In Vivo 2020 PubMed ID: 32354886 DOI: 10.21873/invivo.11869

13093 Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. Protection of Bortezomib-induced Neurotoxicity by Antioxidants. Anticancer Res 2020 PubMed ID: 32620607 DOI: 10.21873/anticanres.14357

13205 Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H. Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro. Anticancer Res 2020 PubMed ID: 32878776 DOI: 10.21873/anticanres.14491

13427 Thahomina Khan, Kazunori Igarashi, Ami Tanabe, Taiki Miyazawa, Shigeto Fukushima, Yutaka Miura, Yu Matsumoto, Tatsuya Yamasoba, Akira Matsumoto, Horacio Cabral, and Kazunori Kataoka Structural Control of Boronic Acid Ligands Enhances Intratumoral Targeting of Sialic Acid To Eradicate Cancer Stem-like Cells ACS Appl. Bio Mater. 2020 PubMed ID: 35021680 DOI: 10.1021/acsabm.0c00530

13775 Al-Tayar BA, Ahmad A, Yusoff ME, Abdullah SF, Mohamad NK, Md Hashim SN, Kishida S, Kishida M, Nakamura N, Kibe T, Harun MH. Cytotoxic Effects of Betel Quid and Areca Nut Aqueous Extracts on Mouse Fibroblast, Human Mouth-Ordinary-Epithelium 1 and Human Oral Squamous Cell Carcinoma Cell Lines Asian Pac J Cancer Prev 2020 21(4):1005-1009 PubMed ID: 32334462 DOI: 10.31557/APJCP.2020.21.4.1005

13783 Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy Cancer Sci 2020 111(1):127-136. PubMed ID: 31692172 DOI: 10.1111/cas.14224

13853 Rizwan Mahmood, Jawaad Ahmed Asif, Wan Nazatul, Shima Shahidan Stingless-bee (Trigona itama) honey adversely impacts the growth of oral squamous cell carcinoma cell lines (HSC-2) European Journal of Integrative Medicine 2020 37 DOI: 10.1016/j.eujim.2020.101162

13903 Aika Tanzawa et al. Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma Oral Science International 2020 17(2):67-72 DOI: 10.1002/osi2.1044

11300 Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A. Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma. Int. J. Oncol. 2019 PubMed ID: 30431077 DOI: 10.3892/ijo.2018.4631

11354 Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K. Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30587341 DOI: 10.1016/j.bbrc.2018.12.066

11363 Nishioka T, Tada H, Ibaragi S, Chen C, Sasano T. Nicotine exposure induces the proliferation of oral cancer cells through the α7 subunit of the nicotinic acetylcholine receptor. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30598264 DOI: 10.1016/j.bbrc.2018.12.154

11620 Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H. Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives. Anticancer Res. 2019 PubMed ID: 31262875 DOI: 10.21873/anticanres.13497

6911 Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H. β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro. J Oral Microbiol 2019 11(1):1609839. PubMed ID: 31105901 DOI: 10.1080/20002297.2019.1609839

9696 Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma Exp Cell Res 2019 384(2):111622 PubMed ID: 31518558 DOI: 10.1016/j.yexcr.2019.111622

9726 Mohamed A A Orabi, Esam A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl ( m-GO- m-GOG)-Type Ellagitannins From the Galls of Tamarix aphylla J Nat Prod 2019 82(10):2682-2695 PubMed ID: 31532650 DOI: 10.1021/acs.jnatprod.9b00073

9890 Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement J Cancer 2019 10(16):3728-3734 PubMed ID: 31333790 DOI: 10.7150/jca.32281

11907 Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Dis. Markers 2019 PubMed ID: 31019584 DOI: 10.1155/2019/8040361

11931 Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs. Anticancer Res. 2019 PubMed ID: 31810932 DOI: 10.21873/anticanres.13882

11933 Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones. Anticancer Res. 2019 PubMed ID: 31810912 DOI: 10.21873/anticanres.13862

12456 Bilginer S, Gul HI, Erdal FS, Sakagami H, Levent S, Gulcin I, Supuran CT. Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2( 3H)-benzoxazolones J Enzyme Inhib Med Chem 2019 34(1):1722-1729 PubMed ID: 31576761 DOI: 10.1080/14756366.2019.1670657

12457 Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. SYT12 plays a critical role in oral cancer and may be a novel therapeutic target J Cancer 2019 10(20):4913-4920 PubMed ID: 31598163 DOI: 10.7150/jca.32582

12458 Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O. Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma Cancer Sci 2019 110(11):3453-3463 PubMed ID: 31444923 DOI: 10.1111/cas.14182

12586 Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner J Clin Biochem Nutr 2019 65(1):8-15 PubMed ID: 31379408 DOI: 10.3164/jcbn.18-91

16176 Kawano S, Ito K, Yahata K, Kira K, Abe T, Akagi T, Asano M, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Kaburagi Y, Yokoi A, Asano O, Owa T, Kishi Y. A landmark in drug discovery based on complex natural product synthesis Sci Rep 2019 9(1):8656 PubMed ID: 31209263 DOI: 10.1038/s41598-019-45001-9

16194 Yamali C, Gul HI, Ece A, Bua S, Angeli A, Sakagami H, Sahin E, Supuran CT. Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors Bioorg Chem 2019 92:103222. PubMed ID: 31499260 DOI: 10.1016/j.bioorg.2019.103222

10618 Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y. Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells. J. Periodont. Res. 2018 53:353-361 PubMed ID: 29159877 DOI: 10.1111/jre.12520

10682 Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. Biochem. Biophys. Res. Commun. 2018 495:2469-2474 PubMed ID: 29278705 DOI: 10.1016/j.bbrc.2017.12.138

10683 Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H. Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma. Biochem. Biophys. Res. Commun. 2018 495:2303-2309 PubMed ID: 29278708 DOI: 10.1016/j.bbrc.2017.12.136

10724 Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters. Anticancer Res. 2018 38:817-823 PubMed ID: 29374707 DOI: 10.21873/anticanres.12289

10727 Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones. Anticancer Res. 2018 38:763-770 PubMed ID: 29374700 DOI: 10.21873/anticanres.12282

10806 Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp. Cell Res. 2018 367:112-118 PubMed ID: 29614312 DOI: 10.1016/j.yexcr.2018.03.041

10829 Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H. In Vitro Anti-tumor Activity of Azulene Amide Derivatives. In Vivo 2018 32:479-486 PubMed ID: 29695549 DOI: 10.21873/invivo.11264

11086 Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones. Anticancer Res. 2018 38(6):3283-3290 PubMed ID: 29848675 DOI: 10.21873/anticanres.12593

11110 Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants. In Vivo 2018 32(4):745-752 PubMed ID: 29936454 DOI: 10.21873/invivo.11303

11115 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(7):3897-3906 PubMed ID: 29970510 DOI: 10.21873/anticanres.12674

11147 Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones. Anticancer Res. 2018 38(8):4449-4457 PubMed ID: 30061209 DOI: 10.21873/anticanres.12747

11148 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(8):4459-4467 PubMed ID: 30061210 DOI: 10.21873/anticanres.12748

11192 Miyaguchi J, Shiga K, Ogawa K, Suzuki F, Katagiri K, Saito D, Ikeda A, Horii A, Watanabe M, Igimi S. Treatment with Lactobacillus Retards the Tumor Growth of Head and Neck Squamous Cell Carcinoma Cells Inoculated in Mice. Tohoku J. Exp. Med. 2018 245(4):269-275 PubMed ID: 30158369 DOI: 10.1620/tjem.245.269

11226 Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer 2018 PubMed ID: 30271493 DOI: 10.7150/jca.25666

11272 Sakagami H, Sugimoto M, Kanda Y, Murakami Y, Amano O, Saitoh J, Kochi A. Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol. Medicines (Basel) 2018 PubMed ID: 30384403 DOI: 10.3390/medicines5040116

4078 Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates Medicinal Chemistry Research 2018 27:2366–2378 DOI: 10.1007/s00044-018-2242-5

4173 Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H. In Vitro Antitumor Activity of Alkylaminoguaiazulenes. In Vivo 2018 PubMed ID: 29695558 DOI: 10.21873/invivo.11273

4235 Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget 2018 PubMed ID: 30333913 DOI: 10.18632/oncotarget.26112

4236 Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J. Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells. Oncol. Rep. 2018 PubMed ID: 29192320 DOI: 10.3892/or.2017.6105

4237 Yamanouchi R, Harada K, Ferdous T, Ueyama Y. Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Mol Clin Oncol 2018 PubMed ID: 29456845 DOI: 10.3892/mco.2018.1548

4239 Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D. Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma. Int. J. Oncol. 2018 PubMed ID: 29344674 DOI: 10.3892/ijo.2018.4247

14708 Arimoto T, Yambe R, Morisaki H, Umezawa H, Kataoka H, Matsui S, Kuwata H. Influence of excess branched-chain amino acid uptake by Streptococcus mutans in human host cells FEMS Microbiol Lett 2018 365(3) PubMed ID: 29240953 DOI: 10.1093/femsle/fnx273

14912 Yun MR, Choi HM, Kang HN, Lee Y, Joo HS, Kim DH, Kim HR, Hong MH, Yoon SO, Cho BC. ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma Oncogene 2018 37(3):377-388 PubMed ID: 28945228 DOI: 10.1038/onc.2017.339

10044 Ohkoshi E, Umemura N. Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells. Int. J. Oncol. 2017 50:387-395 PubMed ID: 28035370 DOI: 10.3892/ijo.2016.3821

10148 Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Exp. Cell Res. 2017 352:357-363 PubMed ID: 28237246 DOI: 10.1016/j.yexcr.2017.02.026

10155 Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer. Sci Rep 2017 7:43379 PubMed ID: 28230172 DOI: 10.1038/srep43379

10191 Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem. Biophys. Res. Commun. 2017 486:385-390 PubMed ID: 28315328 DOI: 10.1016/j.bbrc.2017.03.050

10197 Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T. Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin. Anticancer Res. 2017 37:1023-1029 PubMed ID: 28314260 DOI: 10.21873/anticanres.11412

10201 Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Chalcones. Anticancer Res. 2017 37:1091-1098 PubMed ID: 28314269 DOI: 10.21873/anticanres.11421

10206 Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T. Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas. Molecules 2017 22: PubMed ID: 28294988 DOI: 10.3390/molecules22030470

10241 Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M. A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem. Pharm. Bull. 2017 65:365-372 PubMed ID: 28381677 DOI: 10.1248/cpb.c16-00830

10384 Miyano K, Cabral H, Miura Y, Matsumoto Y, Mochida Y, Kinoh H, Iwata C, Nagano O, Saya H, Nishiyama N, Kataoka K, Yamasoba T. cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. J Control Release 2017 261:275-286 PubMed ID: 28666729 DOI: 10.1016/j.jconrel.2017.06.021

10386 Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y. Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices. In Vivo 2017 31:591-598 PubMed ID: 28652425 DOI: 10.21873/invivo.11099

10395 Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A. Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma. Int. J. Oncol. 2017 51:625-632 PubMed ID: 28656278 DOI: 10.3892/ijo.2017.4050

10418 Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis. J Cancer 2017 8:2033-2041 PubMed ID: 28819404 DOI: 10.7150/jca.18714

10572 Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Aurones. Anticancer Res. 2017 37:6169-6176 PubMed ID: 29061798 DOI: 10.21873/anticanres.12066

10576 Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters. Anticancer Res. 2017 37:6161-6168 PubMed ID: 29061797 DOI: 10.21873/anticanres.12065

10579 Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A. Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma. Anticancer Res. 2017 37:6119-6123 PubMed ID: 29061792 DOI: 10.21873/anticanres.12060

10600 Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y. Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity. Int J Mol Sci 2017 18: PubMed ID: 29112119 DOI: 10.3390/ijms18112358

11036 Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation Int J Cancer Oncol 2017 4: 225- 230 DOI: 10.15436/2377-0902.17.1628

6025 Abé T, Maruyama S, Yamazaki M, Xu B, Babkair H, Sumita Y, Cheng J, Yamamoto T, Saku T. Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia. Exp Mol Pathol 2017 102(2):327-336 PubMed ID: 28242296 DOI: 10.1016/j.yexmp.2017.02.018

6026 Morishima H, Washio J, Kitamura J, Shinohara Y, Takahashi T, Takahashi N. Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH. Sci Rep. 2017 7(1):10092 PubMed ID: 28855722 DOI: 10.1038/s41598-017-10893-y

6029 Ishida S　et al Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis. Biochem Biophys Res Commun 2017 483(1):339-345 PubMed ID: 28017725 DOI: 10.1016/j.bbrc.2016.12.142

12679 Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K. Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Cancer Res 2017 77(9):2363-2374 PubMed ID: 28209617 DOI: 10.1158/0008-5472.CAN-16-2114

14231 Harada K, Ferdous T, Harada T, Takenawa T, Ueyama Y. Gimeracil enhances the antitumor effect of cisplatin in oral squamous cell carcinoma cells in vitro and in vivo Oncol Lett 2017 14(3):3349-3356. PubMed ID: 28927087 DOI: 10.3892/ol.2017.6602

9584 Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H. Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline. In Vivo 2016 30:91-7 PubMed ID: 26912818

9616 Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer 2016 7:600-7 PubMed ID: 27053959 DOI: 10.7150/jca.13820

9630 Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma. J Cancer 2016 7:702-10 PubMed ID: 27076852 DOI: 10.7150/jca.14208

9640 Wang M, Miura Y, Tsuchihashi K, Miyano K, Nagano O, Yoshikawa M, Tanabe A, Makino J, Mochida Y, Nishiyama N, Saya H, Cabral H, Kataoka K. Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. J Control Release 2016 230:26-33 PubMed ID: 27040816 DOI: 10.1016/j.jconrel.2016.03.038

9694 Harada K, Ferdous T, Harada T, Ueyama Y. Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. Int. J. Oncol. 2016 49:276-84 PubMed ID: 27210058 DOI: 10.3892/ijo.2016.3523

9770 Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y. Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors. BMC Cancer 2016 16:548 PubMed ID: 27464948 DOI: 10.1186/s12885-016-2416-9

9808 Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H. Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone. In Vivo 2016 30:645-50 PubMed ID: 27566085

9892 Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y. Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones. Anticancer Res. 2016 36:5803-5812 PubMed ID: 27793902 DOI: 10.21873/anticanres.11164

9896 Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y. Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata. Anticancer Res. 2016 36:5931-5935 PubMed ID: 27793918 DOI: 10.21873/anticanres.11180

9900 Harada K, Ferdous T, Ueyama Y. Gimeracil Exerts Radiosensitizing Effects on Oral Squamous Cell Carcinoma Cells In Vitro and In Vivo. Anticancer Res. 2016 36:5923-5930 PubMed ID: 27793917 DOI: 10.21873/anticanres.11179

9911 Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H. Antiviral and Antitumor Activity of Licorice Root Extracts. In Vivo 2016 30:777-785 PubMed ID: 27815461 DOI: 10.21873/invivo.10994

5809 Ninomiya K et al Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines. J Nat Med 2016 70(3):435-51 PubMed ID: 27178360 DOI: 10.1007/s11418-016-0998-9

5810 Kitagawa N et al The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines. Int J Mol Sci 2016 17(12). pii: E1979 PubMed ID: 27898032 DOI: 10.3390/ijms17121979

6032 Tada H, Shimizu T, Nagaoka I, Takada H. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res 2016 37(3):199-205 PubMed ID: 27356607 DOI: 10.2220/biomedres.37.199

6036 Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer. Int J Oncol. 2016 48(2):607-12 PubMed ID: 26718916 DOI: 10.3892/ijo.2015.3305

6042 Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa Cavin-2 in oral cancer: A potential predictor for tumor progression. Mol Carcinog 2016 55(6):1037-47 PubMed ID: 26086332 DOI: 10.1002/mc.22347

12933 Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer Oncotarget 2016 7(7):8223-39 PubMed ID: 26882562 DOI: 10.18632/oncotarget.6972

14162 Yamali C, Gul HI, Sakagami H, Supuran CT. Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases J Enzyme Inhib Med Chem 2016 31(sup4):125-131 PubMed ID: 27594305 DOI: 10.1080/14756366.2016.1221825

14178 Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T. Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra J Nat Prod 2016 79(4):984-95 PubMed ID: 26938659 DOI: 10.1021/acs.jnatprod.5b01065

14581 Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, Kishi Y, Hamada Y, Masutani M. Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo Int J Mol Sci 2016 17(3):272 PubMed ID: 26927065 DOI: 10.3390/ijms17030272

7196 Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. Anticancer Res. 2015 35:5299-307 PubMed ID: 26408690

7442 Shirako Y, Taya Y, Sato K, Chiba T, Imai K, Shimazu Y, Aoba T, Soeno Y. Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model. J. Oral Pathol. Med. 2015 44:656-68 PubMed ID: 25765182 DOI: 10.1111/jop.12318

5422 Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5. Quantitative Structure-Cytotoxicity Relationship of Oleoylamides. Anticancer Res 2015 5(10):5341-51 PubMed ID: 26408695

6043 Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y. Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells. Toxicol Rep 2015 2:1281-1290 PubMed ID: 28962471 DOI: 10.1016/j.toxrep.2015.09.009

6044 Kasama H　et al Adenosine A2b receptor promotes progression of human oral cancer. BMC Cancer 2015 15:563 PubMed ID: 26228921 DOI: 10.1186/s12885-015-1577-2

6051 Okamoto A　et al Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma. PLoS One 2015 10(11):e0142252 PubMed ID: 26554377 DOI: 10.1371/journal.pone.0142252

6052 Saito T et al Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis. PLoS One 2015 10(9):e0137923 PubMed ID: 26378920 DOI: 10.1371/journal.pone.0137923

6053 Miyamoto I et al Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth. Biochem Biophys Rep 2015 3:26-31 PubMed ID: 29124166 DOI: 10.1016/j.bbrep.2015.07.008

6054 Baba T et al Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway. Mol Carcinog 2015 54(8):608-17 PubMed ID: 24375483 DOI: 10.1002/mc.22127

6058 Shida-Sakazume T et al Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. PLoS One. 2015 10(3):e0120143 PubMed ID: 25803864 DOI: 10.1371/journal.pone.0120143

15042 Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer Cancer Med 2015 4(5):759-69 PubMed ID: 25644496 DOI: 10.1002/cam4.418

15186 Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma Oncoimmunology 2015 4(2):e976077 PubMed ID: 25949874 DOI: 10.4161/2162402X.2014.976077

6056 Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y. Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics. Anticancer Res 2014 34(8):4117-20 PubMed ID: 25075037

6040 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Ando Y, Kanda Y, Hibino Y, Nakajima H, Sakagami H. Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line. In Vivo 2014 28(2):209-15 PubMed ID: 24632975

6038 Hiroshi Sakagami et al Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line Metabolomics 2014 10:270–279 DOI: 10.1007/s11306-013-0576-z

5916 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells. In Vivo 2014 28(4):549-56 PubMed ID: 24982221

5859 Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC. Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma. Biomed Res. 2014 35(6):381-8 PubMed ID: 25743344 DOI: 10.2220/biomedres.35.381

5807 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells. In Vivo 2014 28(5):895-907 PubMed ID: 25189906

5778 Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer. Mol Carcinog 2014 53(7):557-65 PubMed ID: 23371469 DOI: 10.1002/mc.22007

5659 Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of 3-styrylchromones. Anticancer Res 2014 34(10):5405-11 PubMed ID: 25275035

5605 Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M. Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing. PLoS One 2014 9(12):e114121 PubMed ID: 25437003 DOI: 10.1371/journal.pone.0114121

5544 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of phenylpropanoid amides. Anticancer Res 2014 34(7):3543-8 PubMed ID: 24982367

5337 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of piperic acid amides. Anticancer Res 2014 34(9):4877-84 PubMed ID: 25202069

5315 Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H. Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones. Anticancer Res 2014 4(4):1743-50 PubMed ID: 24692705

16010 Fukumoto C, Nakashima D, Kasamatsu A, Unozawa M, Shida-Sakazume T, Higo M, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice Oncoscience 2014 1(12):807-20 PubMed ID: 25621296 DOI: 10.18632/oncoscience.101

5190 Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H. Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4. Acta Med Okayama 2013 67(3):153-64 PubMed ID: 23804138 DOI: 10.18926/AMO/50408

5122 Iida S, Shimada J, Sakagami H. Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines. In Vivo 2013 27(3):321-32 PubMed ID: 23606687

5110 Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res 2013 33(8):3061-8 PubMed ID: 23898061

5028 Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol 2013 139(4):585-94 PubMed ID: 23242234 DOI: 10.1007/s00432-012-1361-5

6065 Miyazaki Y, Fujinami M, Inoue H, Kikuchi K, Ide F, Kusama K. Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma. J Oral Sci 2013 55(4):293-9 PubMed ID: 24351917 DOI: 10.2334/josnusd.55.293

6067 Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K. High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer. Int J Oncol 2013 42(1):141-50 PubMed ID: 23123766 DOI: 10.3892/ijo.2012.1677

6070 Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013 139(4):533-42 PubMed ID: 23207790 DOI: 10.1007/s00432-012-1356-2

6072 Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One 2013 8(2):e56381 PubMed ID: 23418564 DOI: 10.1371/journal.pone.0056381

6076 Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Kinesin family member 4A: a potential predictor for progression of human oral cancer. PLoS One. 2 2013 8(12):e85951 PubMed ID: 24386490 DOI: 10.1371/journal.pone.0085951

6077 Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma. J Oral Pathol Med 2013 42(2):133-9 PubMed ID: 22672247 DOI: 10.1111/j.1600-0714.2012.01182.x

6078 Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K. Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J 2013 30(6):585-97 PubMed ID: 23242548 DOI: 10.1007/s10719-012-9458-2

6081 Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation. BMC Cancer 2013 13:555 PubMed ID: 24261884 DOI: 10.1186/1471-2407-13-555

6083 Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy. Br J Cancer 2013 109(8):2155-66 PubMed ID: 24045666 DOI: 10.1038/bjc.2013.577

15086 Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H. Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells Oncol Rep 2013 29(4):1349-55 PubMed ID: 23354949 DOI: 10.3892/or.2013.2251

16085 Ferdous T, Harada K, Kin T, Harada T, Ueyama Y. Efficacy of schedule-dependent metronomic S-1 chemotherapy in human oral squamous cell carcinoma cells Int J Oncol 2013 43(1):271-9 PubMed ID: 23695365 DOI: 10.3892/ijo.2013.1950

16313 Ohkoshi E Amano S Efficient Utilization of Plant Resources by Alkaline Extraction Alternative & Integrative Medicine 2013 02 DOI: 10.4172/2327-5162.1000133

6087 Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K. Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines. J Oral Sci 2012 54(1):71-5 PubMed ID: 22466889 DOI: 10.2334/josnusd.54.71

6088 Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H. Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness. J Pathol 2012 228(2):181-92 PubMed ID: 22262311 DOI: 10.1002/path.3993

6089 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines. J Oral Sci 2012 54(3):241-50 PubMed ID: 23047035 DOI: 10.2334/josnusd.54.241

6091 Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T. Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages. Microbes Infect 2012 14(11):916-21 PubMed ID: 22561467 DOI: 10.1016/j.micinf.2012.04.015

6095 Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H. Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma. Oncol Lett 2012 3(2):273-280 PubMed ID: 22740894 DOI: 10.3892/ol.2011.473

6098 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity. Tumour Biol 2012 33(1):183-94 PubMed ID: 22081310 DOI: 10.1007/s13277-011-0261-7

15671 Harada T, Harada K, Ueyama Y. The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma Int J Oncol 2012 41(2):565-72 PubMed ID: 22664937 DOI: 10.3892/ijo.2012.1501

15740 Hashimoto T, Soeno Y, Maeda G, Taya Y, Aoba T, Nasu M, Kawashiri S, Imai K. Progression of oral squamous cell carcinoma accompanied with reduced E-cadherin expression but not cadherin switch PLoS One 2012 7(10):e4789 PubMed ID: 23110125 DOI: 10.1371/journal.pone.0047899

7601 Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H. Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives. Anticancer Res. 2011 31:4231-8 PubMed ID: 22199286

7764 Otsuki S, Sugiyama K, Amano O, Yasui T, Sakagami H. Negative regulation of NaF-induced apoptosis by Bad-CAII complex. Toxicology 2011 287:131-6 PubMed ID: 21708216 DOI: 10.1016/j.tox.2011.06.007

7967 Iwasaka K, Tomita K, Ozawa Y, Katayama T, Sakagami H. Effect of CO2 laser irradiation on hormesis induction in cultured oral cells. In Vivo 2011 25:93-8 PubMed ID: 21282740

5323 Jitsuno M, Yokosuka A, Hashimoto K, Amano O, Sakagami H, Mimaki Y. Chemical constituents of Lycoris albiflora and their cytotoxic activities. Nat Prod Commun 2011 6(2):187-92 PubMed ID: 21425671

6116 Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H. Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells. Oncol Rep 2011 25(3):795-802 PubMed ID: 21206983 DOI: 10.3892/or.2010.1130

8085 Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. In Vivo 2010 24:735-43 PubMed ID: 20952742

8406 Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y. NOD1 and NOD2 mediate sensing of periodontal pathogens. J. Dent. Res. 2010 89:186-91 PubMed ID: 20040739 DOI: 10.1177/0022034509354843

19126 Shintani S, Hamakawa H, Nakashiro K, Shirota T, Hatori M, Tanaka M, Kuroshita Y, Kurokawa Y. Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma Int J Oral Maxillofac Surg 2010 39(11):1115-9 PubMed ID: 20709497 DOI: 10.1016/j.ijom.2010.02.027

5611 Wakabayashi H, Narita T, Suga A, Sakagami H. Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives. In Vivo 2010 24(1):39-44 PubMed ID: 20133973

6119 Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T. Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. Biochem Biophys Res Commun 2010 391(2):1192-6 PubMed ID: 20004645 DOI: 10.1016/j.bbrc.2009.12.029

6120 Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Biochem Biophys Res Commun 2010 391(4):1785-91 PubMed ID: 20045673 DOI: 10.1016/j.bbrc.2009.12.156

6122 Nomi N, Kodama S, Suzuki M. Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway. Oncol Rep 2010 24(1):225-31 PubMed ID: 20514466 DOI: 10.3892/or_00000850

6123 Yuji Miyazaki　et al Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer J Cancer Sci Ther 2010 2(2) :26-32

6127 Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H. Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines. Anticancer Res 2009 29(8):3079-86 PubMed ID: 19661319

6128 Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A. Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure. Anticancer Res 2009 29(1):455-64 PubMed ID: 19331186

6129 Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H. Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives. Anticancer Res 2009 29(4):1123-30 PubMed ID: 19414354

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x

6136 Okamura M, Shimada J, Sakagami H. Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines. Anticancer Res 2008 28(1A):253-9 PubMed ID: 18383853

6138 Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines. Anticancer Res 2008 28(2A):1069-78 PubMed ID: 18507056

6141 Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I. Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma. Cancer Sci 2008 99(7):1390-400 PubMed ID: 18452558 DOI: 10.1111/j.1349-7006.2008.00838.x

6142 Okamura M, Kobayashi M, Suzuki F, Shimada J, Sakagami H. Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line. Anticancer Res 2007 27(5A):3331-7 PubMed ID: 17970078

6143 Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res. 2007 27(1A):133-43 PubMed ID: 17352225

6148 Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H. Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines. Anticancer Res 2006 26(3A):1917-23 PubMed ID: 16827125

6150 Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene 2006 25(8):1216-24 PubMed ID: 16247456 DOI: 10.1038/sj.onc.1209158

6152 Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H. Cytotoxic activity of azulenequinones against human oral tumor cell lines. Anticancer Res 2005 25(1A):305-12 PubMed ID: 15816552