Search
CELL BANK Website

Back Back
Cell No. : Cell Name
RCB1939 : NUGC-4  update : 2024/08/14
CommentHuman cell line derived from signet ring cell carcinoma of stomach. TKG0449 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0449
Animal _human < Mammals
Genus Homo
Species sapiens
Tissue stomach
Disease name Signet ring cell carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0449)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_3082
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Isozyme LD, NP
STR(human) OK
Reference information Reference 6
User's Publication 81


To topTop
Reference
3129  Kobayashi M, Nagata S, Iwasaki T, Yanagihara K, Saitoh I, Karouji Y, Ihara S, Fukui Y  Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase.  Proc Natl Acad Sci U S A  1999  96:4874-9  PubMed ID: 10220386   DOI: 10.1073/pnas.96.9.4874
3128  Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao, H Y, Nagai Y, Takagi H  Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.  Jpn J Cancer Res.  1991  82:1428-35  PubMed ID: 1778766   DOI: 10.1111/j.1349-7006.1991.tb01816.x
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682   DOI: 10.1111/j.1349-7006.1990.tb03332.x
3127  Yoshikawa K, Furukawa K, Ueda R, Iwasa S, Lloyd, K O, Notake K, Takahashi T  A human monoclonal antibody recognizing a surface antigen on stomach cancer cells.  Jpn J Cancer Res (--> Cancer Sci)  1989  80:546-53  PubMed ID: 2474525   DOI: 10.1111/j.1349-7006.1989.tb01674.x
5049  Akiyama S, Amo H, Watanabe T, Matsuyama M, Sakamoto J, Imaizumi M, Ichihashi H, Kondo T, Takagi H.  Characteristics of three human gastric cancer cell lines, NU-GC-2, NU-GC-3 and NU-GC-4.  Jpn J Surg  1988  18(4):438-46  PubMed ID: 3172586   DOI: 10.1007/bf02471470
3126  Yokoyama I, Watanabe T, Nishikimi M, Ichihashi H, Kondo T, Takagi H, Sakuma S  Radioimmunoscintigraphy of human gastric carcinoma xenografts with 125I-labeled monoclonal antibody.  Jpn J Cancer Res  1986  77:1114-21  PubMed ID: 3098721  

To topTop
User's Publication
21759  Cao Z, Hou Y, Zhao Z, Zhang H, Tian L, Zhang Y, Dong C, Guo F, Tan L, Han Y, Wang W, Jiao S, Tang Y, An L, Zhou Z.  Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity.  J Biol Chem  2024  300(6):107311  PubMed ID: 38657866   DOI: 10.1016/j.jbc.2024.107311
17881  Kimura Y, Ohzawa H, Miyato H, Kaneko Y, Kuchimaru T, Takahashi R, Yamaguchi H, Kurashina K, Saito S, Hosoya Y, Lefor AK, Sata N, Kitayama J.  Intraperitoneal transfer of microRNA-29b-containing small extracellular vesicles can suppress peritoneal metastases of gastric cancer  Cancer Sci  2023  Mar 20  PubMed ID: 36939028   DOI: 10.1111/cas.15793
19708  Hachisu K, Tsuchida A, Takada Y, Mizuno M, Ideo H.  Galectin-4 Is Involved in the Structural Changes of Glycosphingolipid Glycans in Poorly Differentiated Gastric Cancer Cells with High Metastatic Potential  Int J Mol Sci  2023  24(15):12305  PubMed ID: 37569679   DOI: 10.3390/ijms241512305
19729  Sato T, Saito M, Nakajima S, Saito K, Katagata M, Fukai S, Okayama H, Sakamoto W, Saze Z, Momma T, Mimura K, Kono K.  ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer  Gastric Cancer  2023  26(3):379-392  PubMed ID: 36811690   DOI: 10.1007/s10120-023-01373-6
19939  hiozaki A, Fukami T, Shimizu H, Kosuga T, Kudou M, Takemoto K, Katsurahara K, Nishibeppu K, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Otsuji E.  Effects of TRPV2 on the Expression of PD-L1 and Its Binding Ability to PD-1 in Gastric Cancer  Ann Surg Oncol  2023  30(13):8704-8716  PubMed ID: 37599296   DOI: 10.1245/s10434-023-14084-0
21122  Ideo H, Tsuchida A, Takada Y, Kinoshita J, Inaki N, Minamoto T.  Suppression of galectin-4 attenuates peritoneal metastasis of poorly differentiated gastric cancer cells.  Gastric Cancer  2023    PubMed ID: 36695981   DOI: 10.1007/s10120-023-01366-5
21458  Kitagawa H, Hiraki M, Namba T, Baba K, Miyake S, Ito K, Tanaka T, Noshiro H.  The Oncological Effect of Mutant p53 on the Metastatic Phenotype of Gastric Cancer Cells.  Anticancer Res  2023  43(11):4887-4895  PubMed ID: 37909947   DOI: 10.21873/anticanres.16686
21486  Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H.  Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway.  Ann Surg Oncol  2023    PubMed ID: 38006530   DOI: 10.1245/s10434-023-14586-x
17567  Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer  Cancer Sci  2022  113(6):1984-1998  PubMed ID: 35307915   DOI: 10.1111/cas.15342
17646  Ogawa K, Yamada K, Etoh T, Kitagawa M, Shirasaka Y, Noguchi K, Kobayashi T, Nishizono A, Inomata M.  Development of an oncolytic mammalian orthoreovirus expressing the near-infrared fluorescent protein iRFP720  J Virol Methods  2022  308:114574  PubMed ID: 35798198   DOI: 10.1016/j.jviromet.2022.114574
20459  Kato S, Shiozaki A, Kudou M, Shimizu H, Kosuga T, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway.  Ann Surg Oncol  2022    PubMed ID: 34855064   DOI: 10.1245/s10434-021-11132-5
20609  Shen Y, Eng JS, Fajardo F, Liang L, Li C, Collins P, Tedesco D, Nolan-Stevaux O.  Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway.  J Immunother Cancer  2022  10(3)  PubMed ID: 35296559   DOI: 10.1136/jitc-2021-004348
20622  Takaki W, Konishi H, Matsubara D, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Role of Extracellular High-Mobility Group Box-1 as a Therapeutic Target of Gastric Cancer.  Int J Mol Sci  2022  23(6)  PubMed ID: 35328684   DOI: 10.3390/ijms23063264
20627  Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.  Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.  Sci Rep  2022  12(1):5050  PubMed ID: 35322078   DOI: 10.1038/s41598-022-08904-8
20661  Inoue H, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functions and Clinical Significance of CACNA2D1 in Gastric Cancer.  Ann Surg Oncol  2022    PubMed ID: 35445337   DOI: 10.1245/s10434-022-11752-5
16894  Kimura Y, Ohzawa H, Miyato H, Kaneko Y, Saito A, Takahashi K, Tojo M, Yamaguchi H, Kurashina K, Saito S, Hosoya Y, Lefor AK, Sata N, Kitayama J.  MiR-29b may suppresses peritoneal metastases through inhibition of the mesothelial-mesenchymal transition (MMT) of human peritoneal mesothelial cells  Sci Rep  2022  12(1):205  PubMed ID: 34997082   DOI: 10.1038/s41598-021-04065-2
16979  Ma J, Zhang C, Liang W, Li L, Du J, Pan C, Chen B, Chen Y, Wang Y.  ω-3 and ω-6 Polyunsaturated Fatty Acids Regulate the Proliferation, Invasion and Angiogenesis of Gastric Cancer Through COX/PGE Signaling Pathway  Front Oncol  2022  12:802009  PubMed ID: 35251974   DOI: 10.3389/fonc.2022.802009
21996  Fukami T, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Morinaga Y, Konishi E, Otsuji E.  Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer  World J Gastroenterol  2022  28(32):4649-4667.  PubMed ID: 36157935   DOI: 10.3748/wjg.v28.i32.4649
18099  Kato T, Nakamori M, Matsumura S, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H.  Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer  Oncol Lett  2021  21(6):490  PubMed ID: 33968206   DOI: 10.3892/ol.2021.12751
13160  Sakuratani T, Takeuchi T, Yasufuku I, Iwata Y, Saigo C, Kito Y, Yoshida K.  Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway.  Virchows Arch  2021  478(3):401-411  PubMed ID: 32789692   DOI: 10.1007/s00428-020-02899-1
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
13337  Kim S, Ahn JM, Bae WJ, Han JH, Lee D.  Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer.  Gastric Cancer  2021  24(3):577-588  PubMed ID: 33164142   DOI: 10.1007/s10120-020-01139-4
20116  Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway.  Gastric Cancer  2021    PubMed ID: 33864161   DOI: 10.1007/s10120-021-01187-4
20135  Saitoh Y, Kawasaki N, Eguchi N, Ikeshima M.  Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4.  Free Radic Res  2021  1-10  PubMed ID: 33929281   DOI: 10.1080/10715762.2021.1902514
20148  Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E.  β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.  Sci Rep  2021  11(1):10664  PubMed ID: 34021168   DOI: 10.1038/s41598-021-88982-2
14345  Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer  Cancer Sci  2021  112(3):1026-1037.   PubMed ID: 33404124   DOI: 10.1111/cas.14796
20213  Kuramitsu S, Masuda T, Hu Q, Tobo T, Yashiro M, Fujii A, Kitagawa A, Abe T, Otsu H, Ito S, Oki E, Mori M, Mimori K.  Cancer-associated Fibroblast-derived Spondin-2 Promotes Motility of Gastric Cancer Cells.  Cancer Genomics Proteomics  2021  18(4):521-529  PubMed ID: 34183385   DOI: 10.21873/cgp.20277
20224  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Ohashi T, Okamoto K, Kuriki Y, Hanaoka K, Urano Y, Otsuji E.  Matrix metalloprotease-14 is a Target Enzyme for Detecting Peritoneal Metastasis in Gastric Cancer.  Photodiagnosis Photodyn Ther  2021    PubMed ID: 34242818   DOI: 10.1016/j.pdpdt.2021.102420
20286  Zhang X, Yamamoto Y, Wang X, Sato M, Imanishi M, Sugaya A, Hirose M, Endo S, Moriwaki T, Yamato K, Hyodo I.  MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53.  Anticancer Res  2021  41(3):1475-1483  PubMed ID: 33788740   DOI: 10.21873/anticanres.14906
20520  Komatsu S, Imamura T, Kiuchi J, Takashima Y, Kamiya H, Ohashi T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Otsuji E.  Depletion of tumor suppressor miRNA-148a in plasma relates to tumor progression and poor outcomes in gastric cancer.  Am J Cancer Res  2021  11(12):6133-6146  PubMed ID: 35018247  
16126  Nakamura K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  The expression of the alpha1 subunit of Na +/K +-ATPase is related to tumor development and clinical outcomes in gastric cancer  Gastric Cancer  2021  24(6):1278-1292  PubMed ID: 34251542   DOI: 10.1007/s10120-021-01212-6
16866  Yamashita K, Iwatsuki M, Yasuda-Yoshihara N, Morinaga T, Nakao Y, Harada K, Eto K, Kurashige J, Hiyoshi Y, Ishimoto T, Nagai Y, Iwagami S, Baba Y, Miyamoto Y, Yoshida N, Ajani JA, Baba H.  Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer  Br J Cancer  2021  124(3):595-603  PubMed ID: 33100329   DOI: 10.1038/s41416-020-01138-3
14297  Kumagai Y, Ohzawa H, Miyato H, Horie H, Hosoya Y, Lefor AK, Sata N, Kitayama J.  Surgical Stress Increases Circulating Low-Density Neutrophils Which May Promote Tumor Recurrence  J Surg Res  2020  246:52-61  PubMed ID: 31561178   DOI: 10.1016/j.jss.2019.08.022
19269  Shun Zhang, Yoshinori Kohira, Hajime Orita, Momoko Ishimine, Toshiyuki Kobayashi, Sharlyn Mae Buendia Chua, Hirofumi Nakaoka, Ituro Inoue, Okio Hino, Takehiko Yokomizo, Tetsu Fukunaga, Hyeon-Cheol Lee-Okada  Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation  BPB Reports  2019  2:130-133    DOI: 10.1248/bpbreports.2.6_130
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11733  Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.  Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells.  Int. J. Oncol.  2019    PubMed ID: 31432150   DOI: 10.3892/ijo.2019.4853
11969  Desamero MJ, Kakuta S, Tang Y, Chambers JK, Uchida K, Estacio MA, Cervancia C, Kominami Y, Ushio H, Nakayama J, Nakayama H, Kyuwa S.  Tumor-suppressing potential of stingless bee propolis in in vitro and in vivo models of differentiated-type gastric adenocarcinoma.  Sci Rep  2019    PubMed ID: 31873082   DOI: 10.1038/s41598-019-55465-4
11499  S Zhang et al  Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation  BPB Reports  2019  2,130-133   
12331  Imanishi M, Yamamoto Y, Wang X, Sugaya A, Hirose M, Endo S, Natori Y, Yamato K, Hyodo I.  Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells  Cancer Sci   2019  110(2):639-649  PubMed ID: 30488540   DOI: 10.1111/cas.13893
11246  Kimura R, Yoneshige A, Hagiyama M, Otani T, Inoue T, Shiraishi N, Yanagihara K, Wakayama T, Ito A.  Expression of cell adhesion molecule 1 in gastric neck and base glandular cells: Possible involvement in peritoneal dissemination of signet ring cells.  Life Sci.  2018    PubMed ID: 30312702   DOI: 10.1016/j.lfs.2018.10.017
4190  Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M.  Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.  Oncol. Rep.  2018    PubMed ID: 29138864   DOI: 10.3892/or.2017.6093
4313  Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E.  Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.  Am J Cancer Res  2018    PubMed ID: 30662802  
14602  Kanamaru R, Ohzawa H, Miyato H, Yamaguchi H, Hosoya Y, Lefor AK, Sata N, Kitayama J.  Neutrophil Extracellular Traps Generated by Low Density Neutrophils Obtained from Peritoneal Lavage Fluid Mediate Tumor Cell Growth and Attachment  J Vis Exp  2018  (138):58201  PubMed ID: 30124642   DOI: 10.3791/58201
14733  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma  Carcinogenesis  2018  39(2):263-271  PubMed ID: 29228320   DOI: 10.1093/carcin/bgx139
10082  Jia L, Ren S, Li T, Wu J, Zhou X, Zhang Y, Wu J, Liu W.  Effects of Combined Simultaneous and Sequential Endostar and Cisplatin Treatment in a Mice Model of Gastric Cancer Peritoneal Metastases.  Gastroenterol Res Pract  2017  2017:2920384  PubMed ID: 28197204   DOI: 10.1155/2017/2920384
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336   DOI: 10.1016/j.canlet.2017.04.002
10586  Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M.  The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios.  Oncotarget  2017  8:74567-74581  PubMed ID: 29088808   DOI: 10.18632/oncotarget.20209
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969   DOI: 10.18632/oncotarget.20860
5804  Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki  Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26  Oncology Letters  2017  13(1):215-221  PubMed ID: 28123544   DOI: 10.3892/ol.2016.5386
9931  Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito  Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications  Front Physiol  2017  8:997  PubMed ID: 29259558   DOI: 10.3389/fphys.2017.00997
14271  Muguruma N, Okamoto K, Nakagawa T, Sannomiya K, Fujimoto S, Mitsui Y, Kimura T, Miyamoto H, Higashijima J, Shimada M, Horino Y, Matsumoto S, Hanaoka K, Nagano T, Shibutani M, Takayama T.  Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1  Sci Rep  2017  7(1):6536  PubMed ID: 28747791   DOI: 10.1038/s41598-017-06857-x
14615  Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.  Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer  Oncotarget   2017  8(64):107666-107677  PubMed ID: 29296196   DOI: 10.18632/oncotarget.22587
14738  Wei H, Cai H, Jin Y, Wang P, Zhang Q, Lin Y, Wang W, Cheng J, Zeng N, Xu T, Zhou A.  Structural basis of a novel heterodimeric Fc for bispecific antibody production  Oncotarget   2017  8(31):51037-51049  PubMed ID: 28881627   DOI: 10.18632/oncotarget.17558
14744  Ohashi T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Imamura T, Kiuchi J, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma  Br J Cancer  2017  116(2):218-226  PubMed ID: 27898655   DOI: 10.1038/bjc.2016.394
10862    Bioequivalence Studies of A Generic Formulation (SW651K) to the Brand Drug S-1 in Tumor-Bearing Rat Models  Journal of Bioequivalence & Bioavailability  2016  8(3): 112-117    DOI: 10.4172/jbb.1000279
5815  Tamura F et al  RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.  Gastric Cancer  2016  19(1):85-97  PubMed ID: 25532910   DOI: 10.1007/s10120-014-0454-z
7233  Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.  Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.  Sci Rep  2015  5:13474  PubMed ID: 26310847   DOI: 10.1038/srep13474
15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
10870  Waraya M, Yamashita K, Ema A, Katada N, Kikuchi S, Watanabe M.  Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype  PLoS One  2015  10(10):e0139902  PubMed ID: 26447864   DOI: 10.1371/journal.pone.0139902
5827  Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.  ERC/mesothelin is expressed in human gastric cancer tissues and cell lines.  Oncol Rep  2014  31(1):27-33  PubMed ID: 24146039   DOI: 10.3892/or.2013.2803
5830  Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I.  Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.  PLoS One  2014  9(7):e102831  PubMed ID: 25033286   DOI: 10.1371/journal.pone.0102831
5833  Sato M, Muguruma N, Nakagawa T, Okamoto K, Kimura T, Kitamura S, Yano H, Sannomiya K, Goji T, Miyamoto H, Okahisa T, Mikasa H, Wada S, Iwata M, Takayama T.  High antitumor activity of pladienolide B and its derivative in gastric cancer.  Cancer Sci  2014  105(1):110-6  PubMed ID: 24635824   DOI: 10.1111/cas.12317
15817  Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G.  A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines  PLoS One  2014  9(2):e90155  PubMed ID: 24587255   DOI: 10.1371/journal.pone.0090155
15903  Takabayashi K, Kashiwagi K, Kawata T, Sato T, Matsuoka K, Hisamatsu T, Takaishi H, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T.  Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin  Cancer Biol Ther  2014  15(1):81-8  PubMed ID: 24149371   DOI: 10.4161/cbt.26610
5845  Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K.  Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.  PLoS One  2013  8(2):e56766  PubMed ID: 23451082   DOI: 10.1371/journal.pone.0056766
15081  Awazu Y, Nakamura K, Mizutani A, Kakoi Y, Iwata H, Yamasaki S, Miyamoto N, Imamura S, Miki H, Hori A.  A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities  Mol Cancer Ther  2013  12(6):913-24  PubMed ID: 23548264   DOI: 10.1158/1535-7163.MCT-12-1011
16082  Fujita H, Miyadera K, Kato M, Fujioka Y, Ochiiwa H, Huang J, Ito K, Aoyagi Y, Takenaka T, Suzuki T, Ito S, Hashimoto A, Suefuji T, Egami K, Kazuno H, Suda Y, Nishio K, Yonekura K.  The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile  Mol Cancer Ther  2013  12(12):2685-96  PubMed ID: 24140932   DOI: 10.1158/1535-7163.MCT-13-0459
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071   DOI: 10.3892/ijo.2012.1485
5855  Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP.  Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.  J Proteome Res  2012  11(12):5736-47  PubMed ID: 23116296   DOI: 10.1021/pr300555y
7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856   DOI: 10.1038/sj.bjc.6606075
8007  Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.  Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.  Cancer Sci.  2011  102:605-13  PubMed ID: 21205074   DOI: 10.1111/j.1349-7006.2010.01821.x
16307  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K, Watanabe M.  Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer  BMC Cancer  2011  11:122  PubMed ID: 21466710   DOI: 10.1186/1471-2407-11-122
8320  Tanaka Y, Matsuo K, Yuzuriha S, Yan H, Nakayama J.  Non-thermal cytocidal effect of infrared irradiation on cultured cancer cells using specialized device.  Cancer Sci.  2010  101:1396-402  PubMed ID: 20345484   DOI: 10.1111/j.1349-7006.2010.01548.x
18757  Kawaguchi K, Etoh T, Suzuki K, Mitui MT, Nishizono A, Shiraishi N, Kitano S.  Efficacy of oncolytic reovirus against human gastric cancer with peritoneal metastasis in experimental animal model  Int J Oncol  2010  37(6):1433-8  PubMed ID: 21042711   DOI: 10.3892/ijo_00000795
18975  Yang Y, Lim SK, Choong LY, Lee H, Chen Y, Chong PK, Ashktorab H, Wang TT, Salto-Tellez M, Yeoh KG, Lim YP.  Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins  J Proteome Res  2010  4767-78  PubMed ID: 20812763   DOI: 10.1021/pr100492x
8557  Konishi H, Kikuchi S, Ochiai T, Ikoma H, Kubota T, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Sonoyama T, Kokuba Y, Sasaki H, Matsui T, Otsuji E.  Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice.  Anticancer Res.  2009  29:2091-7  PubMed ID: 19528469  
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
18966  Ma J, Sawai H, Matsuo Y, Ochi N, Yasuda A, Takahashi H, Wakasugi T, Funahashi H, Sato M, Okada Y, Takeyama H, Manabe T.  Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell lines  J Surg Res  2008  148(2):197-204  PubMed ID: 18395750   DOI: 10.1016/j.jss.2007.08.014
6139  Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y.  IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.  Int J Cancer  2008  122(5):1040-6  PubMed ID: 17957782   DOI: 10.1002/ijc.23181
5893  Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T.  Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer.  Clin Exp Metastasis  2007  24(3):179-89  PubMed ID: 17487561   DOI: 10.1007/s10585-007-9067-9



Back Back Return Top Page