Cell No. : Cell Name RCB1935 : HPB-ALL  update : 2024/01/17
Comment			Human cell line derived from T cell leukemia. TKG0199 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	Obinata, Masuo
		Year of deposit	2004
		Original cell	TKG0199
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Race	Japanese
		Gender	Male
		Tissue	blood
		Disease name	T cell leukemia
		Classification	cancer
		History	Cell Resource Center for Biomedical Research, Tohoku University（TKG0199）
		Lifespan	infinite
		Morphology	lymphocyte-like
		Cellosaurus(Expasy)	CVCL_1820
			deposit info	lot info
		Medium	Medium List
		Culture type		Suspension cells
		Culture medium		RPMI1640 + 10% FBS
		Culture method
		Antibiotics		Free
		Passage method		dilution
	Culture information	Passage ratio		1 : 10 split
		SC frequency		Subculture : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma		(-)
		Virus (HIV)		LT 400
		Virus (HTLV-1)		(-)
		Isozyme		LD, NP
		STR(human)		OK
Reference information		Reference	2
		User's Publication	6

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Reference

5071  Drexler HG, Gaedicke G, Minowada J.  T-leukemia cell lines CCRF-CEM, HPB-ALL, JM and MOLT-4: changes in isoenzyme profiles during induction of differentiation.  Blut  1987  54(2):79-87  PubMed ID: 3493047   DOI: 10.1007/bf00321034

5047  Morikawa S, Tatsumi E, Baba M, Harada T, Yasuhira K.  Two E-rosette-forming lymphoid cell lines.  Int J Cancer  1978  21(2):166-70  PubMed ID: 203546   DOI: 10.1002/ijc.2910210207

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User's Publication

20393  Makita Y, Saito S, Tsuchiya A, Ishibashi M, Arai MA.  Identification of 1β,2α-epoxytagitinin C as a Notch inhibitor, oxidative stress mechanism and its anti-leukemia activity.  J Nat Med  2022    PubMed ID: 34779991   DOI: 10.1007/s11418-021-01584-0

13112  Tsuchiya A, Makita Y, Koyano T, Kowithayakorn T, Ishibashi M, Arai MA.  Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors.  J Nat Med  2020    PubMed ID: 32648094   DOI: 10.1007/s11418-020-01432-7

10804  Arai MA, Akamine R, Tsuchiya A, Yoneyama T, Koyano T, Kowithayakorn T, Ishibashi M.  The Notch inhibitor cowanin accelerates nicastrin degradation.  Sci Rep  2018  8:5376  PubMed ID: 29599482   DOI: 10.1038/s41598-018-23698-4

9651  Randhawa S, Cho BS, Ghosh D, Sivina M, Koehrer S, Müschen M, Peled A, Davis RE, Konopleva M, Burger JA.  Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia.  Br. J. Haematol.  2016  174:425-36  PubMed ID: 27071778   DOI: 10.1111/bjh.14075

5608  Zhou X, Koizumi Y, Zhang M, Natsui M, Koyota S, Yamada M, Kondo Y, Hamada F, Sugiyama T.  Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice  Cancer Sci  2015  106(5):635-41  PubMed ID: 25735932   DOI: 10.1111/cas.12651

16810  Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, Kurokawa M, Chiba S, Bailey DK, Kennedy GC, Ogawa S.  A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays  Cancer Res  2005  65(14):6071-9  PubMed ID: 16024607   DOI: 10.1158/0008-5472.CAN-05-0465