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Cell No. : Cell Name
RCB1935 : HPB-ALL  update : 2024/01/17
CommentHuman cell line derived from T cell leukemia. TKG0199 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0199
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Tissue blood
Disease name T cell leukemia
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0199)
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_1820
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) LT 400
Virus (HTLV-1) (-)
Isozyme LD, NP
STR(human) OK
Reference information Reference 2
User's Publication 7

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5071  Drexler HG, Gaedicke G, Minowada J.  T-leukemia cell lines CCRF-CEM, HPB-ALL, JM and MOLT-4: changes in isoenzyme profiles during induction of differentiation.  Blut  1987  54(2):79-87  PubMed ID: 3493047   DOI: 10.1007/bf00321034
5047  Morikawa S, Tatsumi E, Baba M, Harada T, Yasuhira K.  Two E-rosette-forming lymphoid cell lines.  Int J Cancer  1978  21(2):166-70  PubMed ID: 203546   DOI: 10.1002/ijc.2910210207

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User's Publication
21826  Terasaki T, Semba Y, Sasaki K, Imanaga H, Setoguchi K, Yamauchi T, Hirabayashi S, Nakao F, Akahane K, Inukai T, Sanda T, Akashi K, Maeda T.  The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells.  Leukemia  2024    PubMed ID: 38987275   DOI: 10.1038/s41375-024-02343-2
20393  Makita Y, Saito S, Tsuchiya A, Ishibashi M, Arai MA.  Identification of 1β,2α-epoxytagitinin C as a Notch inhibitor, oxidative stress mechanism and its anti-leukemia activity.  J Nat Med  2022    PubMed ID: 34779991   DOI: 10.1007/s11418-021-01584-0
13112  Tsuchiya A, Makita Y, Koyano T, Kowithayakorn T, Ishibashi M, Arai MA.  Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors.  J Nat Med  2020    PubMed ID: 32648094   DOI: 10.1007/s11418-020-01432-7
10804  Arai MA, Akamine R, Tsuchiya A, Yoneyama T, Koyano T, Kowithayakorn T, Ishibashi M.  The Notch inhibitor cowanin accelerates nicastrin degradation.  Sci Rep  2018  8:5376  PubMed ID: 29599482   DOI: 10.1038/s41598-018-23698-4
9651  Randhawa S, Cho BS, Ghosh D, Sivina M, Koehrer S, Müschen M, Peled A, Davis RE, Konopleva M, Burger JA.  Effects of pharmacological and genetic disruption of CXCR4 chemokine receptor function in B-cell acute lymphoblastic leukaemia.  Br. J. Haematol.  2016  174:425-36  PubMed ID: 27071778   DOI: 10.1111/bjh.14075
5608  Zhou X, Koizumi Y, Zhang M, Natsui M, Koyota S, Yamada M, Kondo Y, Hamada F, Sugiyama T.  Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice  Cancer Sci  2015  106(5):635-41  PubMed ID: 25735932   DOI: 10.1111/cas.12651
16810  Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, Kurokawa M, Chiba S, Bailey DK, Kennedy GC, Ogawa S.  A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays  Cancer Res  2005  65(14):6071-9  PubMed ID: 16024607   DOI: 10.1158/0008-5472.CAN-05-0465

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