CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1933 : NALM-6]

細胞番号 : 細胞名 RCB1933 : NALM-6 update : 2024/11/20
細胞特性(Comment:英)			Human cell line derived from B cell leukemia. TKG0413 (Deposited from Tohoku Univ.).
細胞特性(日)			ヒトＢ細胞白血病細胞由来細胞株。 TKG0413 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)			基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英)			Order Form(C-0005.pdf) MTA(C-0007.pdf) MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日)			依頼書C-0001.pdf 同意書(非営利学術目的)C-0003.pdf 同意書(営利目的)C-0003p.pdf
			提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料			手数料とお支払いについてはこちらをご覧ください。
細胞基本情報		寄託者	Obinata, Masuo
		寄託日	2004
		元の細胞	TKG0413
		動物種	_human < Mammals
		属名	Homo
		種名	sapiens
		採取組織	blood
		病名	B cell of ALL
		細胞分類	cancer
		入手歴	Cell Resource Center for Biomedical Research, Tohoku University（TKG0413）
		細胞寿命	infinite
		細胞形態	lymphocyte-like
		Cellosaurus(Expasy)	CVCL_0092
細胞培養・検査情報			寄託時情報	ロット情報
	培地・試薬情報		培地・試薬一覧はこちらをご覧ください。
		培養形態		Suspension cells
		培養方法		浮遊細胞の培養に関する一般的な注意(Japanese)
		培地		RPMI1640 + 10% FBS
		抗生物質		Free
		継代方法		dilution
		継代密度		1 : 10 split
		継代・培地交換頻度		Subculture : 2 times/week
		培養最適温度		37 ℃
		二酸化炭素濃度		5 %
		凍結培地		Medium + 10% DMSO
		マイコプラズマ/アコレプラズマ		(-)
		ウィルス（HIV)		LT 400
		ウィルス（HTLV-1)		(-)
		アイソザイム検査		LD, NP
		個体識別検査		OK
文献情報		Reference(英)	9件
		Reference(日)	0件
		利用者成果(英)	14件
		利用者成果(日)	0件

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Reference(英)

3527 Rowland AJ, Pietersz GA, McKenzie IF. Preclinical investigation of the antitumour effects of anti-CD19-idarubicin immunoconjugates. Cancer Immunol Immunother 1993 37(3):195-202 PubMed ID: 7687521 DOI: 10.1007/bf01525435

5041 Luo Y, Seon BK. Marked difference in the in vivo antitumor efficacy between two immunotoxins targeted to different epitopes of common acute lymphoblastic leukemia antigen (CD10). Mechanisms involved in the differential activities of immunotoxins. J Immunol 1990 145(6):1974-82 PubMed ID: 1697314

5040 Luo Y, Hara H, Haruta Y, Seon BK. Establishment of ascitic tumor of human pre-B acute lymphoblastic leukemia in nonconditioned nude mice. Cancer Res 1989 49(3):706-10 PubMed ID: 2783384

3522 Pulczynski S, Boesen AM, Jensen OM, Ellegaard J, Hokland P. Immunoelectron microscopy studies on the modulation of common acute lymphoblastic leukemia antigen (CALLA) on NALM-6 cells: delineation of intracellular transport. Leukemia 1989 3(2):137-44 PubMed ID: 2521368

3523 Shipp MA, Vijayaraghavan J, Schmidt EV, Masteller EL, D'Adamio L, Hersh LB, Reinherz EL. Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. Proc Natl Acad Sci U S A 1989 86(1):297-301 PubMed ID: 2521388 DOI: 10.1073/pnas.86.1.297

5042 Haruta Y, Seon BK. Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6. Proc Natl Acad Sci U S A 1986 83(20):7898-902 PubMed ID: 3464004 DOI: 10.1073/pnas.83.20.7898

5045 Han T, Dadey B, Minowada J. Cultured human leukemic non-T/non-B lymphoblasts and their stimulating capacity in "one-way" mixed lymphocyte reaction: suggestive evidence for early T-cell or B-cell precursors. Cancer 1979 44(1):136-40 PubMed ID: 156581 DOI: 10.1002/1097-0142(197907)44:1<136::aid-cncr2820440124>3.0.co;2-i

5043 Han T, Minowada J. Use of stimulating capacity of mixed lymphocyte reaction (MLR-S) as a possible marker for the cell-origin of null-cell acute lymphoblastic leukaemia. Immunology 1978 35(2):333-9 PubMed ID: 155647

5044 Han T, Dadey B, Minowada J. Unique leukemic non-T/non-B lymphoid cell lines (REH and KM-3): absence of MLR-S and presence of suppressor cell activity for normal T-cell response. J Clin Lab Immunol 1978 1(3):237-43 PubMed ID: 159361

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Reference(日)

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利用者成果(英)

19668 Lu X, Lofgren SM, Zhao Y, Mazur PK. Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides Nat Biomed Eng 2023 7(9):1170-1187 PubMed ID: 37652986 DOI: 10.1038/s41551-023-01085-3

21352 Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A. SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. Cell Rep 2023 112940 PubMed ID: 37582370 DOI: 10.1016/j.celrep.2023.112940

20013 Iriguchi S, Yasui Y, Kawai Y, Arima S, Kunitomo M, Sato T, Ueda T, Minagawa A, Mishima Y, Yanagawa N, Baba Y, Miyake Y, Nakayama K, Takiguchi M, Shinohara T, Nakatsura T, Yasukawa M, Kassai Y, Hayashi A, Kaneko S. A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy. Nat Commun 2021 12(1):430 PubMed ID: 33462228 DOI: 10.1038/s41467-020-20658-3

20353 Min Q, Meng X, Zhou Q, Wang Y, Li Y, Lai N, Xiong E, Wang W, Yasuda S, Yu M, Zhang H, Sun J, Wang X, Wang JY. RAG1 splicing mutation causes enhanced B cell differentiation and autoantibody production. JCI Insight 2021 6(19) PubMed ID: 34622798 DOI: 10.1172/jci.insight.148887

16757 Yamashita M, Kuehn HS, Okuyama K, Okada S, Inoue Y, Mitsuiki N, Imai K, Takagi M, Kanegane H, Takeuchi M, Shimojo N, Tsumura M, Padhi AK, Zhang KYJ, Boisson B, Casanova JL, Ohara O, Rosenzweig SD, Taniuchi I, Morio T. A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS Nat Immunol 2021 22(7):893-903 PubMed ID: 34155405 DOI: 10.1038/s41590-021-00951-z

13842 Hsieh HY, Jia W, Jin ZC, Kidoya H, Takakura N. High expression of PSF1 promotes drug resistance and cell cycle transit in leukemia cells Cancer Sci 2020 111(7):2400-2412 PubMed ID: 32391593 DOI: 10.1111/cas.14452

14798 Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Nishimasu H, Nureki O, Ohmura M, Hayakawa N, Hishiki T, Uchibori R, Ozawa K, Yoshimura A. The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells Cancer Res 2020 80(3):471-483 PubMed ID: 31767627 DOI: 10.1158/0008-5472.CAN-19-1196

10269 Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M. Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages J Clin Exp Hematop 2017 57:15-20 PubMed ID: 28420814 DOI: 10.3960/jslrt.17003

14232 Yasunaga M, Manabe S, Matsumura Y. Immunoregulation by IL-7R-targeting antibody-drug conjugates: overcoming steroid-resistance in cancer and autoimmune disease Sci Rep 2017 7(1):10735 PubMed ID: 28878234 DOI: 10.1038/s41598-017-11255-4

18185 Weeks RJ, Ludgate JL, LeMée G, Morison IM. TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells PLoS One 2016 11(3):e0151341 PubMed ID: 26985820 DOI: 10.1371/journal.pone.0151341

9722 Richmond J, Robbins A, Evans K, Beck D, Kurmasheva RT, Billups CA, Carol H, Heatley S, Sutton R, Marshall GM, White D, Pimanda J, Houghton PJ, Smith MA, Lock RB. Acute Sensitivity of Ph-like Acute Lymphoblastic Leukemia to the SMAC-Mimetic Birinapant. Cancer Res. 2016 76:4579-91 PubMed ID: 27302164 DOI: 10.1158/0008-5472.CAN-16-0523

6423 Yamamoto H, Ishimura M, Ochiai M, Takada H, Kusuhara K, Nakatsu Y, Tsuzuki T, Mitani K, Hara T. BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector. Gene Ther 2016 23(2):205-13 PubMed ID: 26280081 DOI: 10.1038/gt.2015.91

13994 Horlad H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, Endo S, Kikukawa Y, Okuno Y, Matsuoka M, Takeya M, Komohara Y. An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma Cancer Sci 2016 107(11):1696-1704 PubMed ID: 27564404 DOI: 10.1111/cas.13065

6132 Naito H, Kidoya H, Sato Y, Takakura N. Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population. J Biochem 2009 145(5):653-9 PubMed ID: 19179360 DOI: 10.1093/jb/mvp021

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