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Cell No. : Cell Name
RCB1928 : KG-1a  update : 2023/07/11
CommentHuman cell line derived from acute myelogenous leukemia. The variant subline of KG-1(RCB1166) cell line. TKG0402 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Obinata, Masuo
Originator Koeffler,H.P. & Golde,D,W.
Year of deposit 2004
Original cell TKG0402
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 59 years
Tissue bone marrow
Disease name acute myelogenous leukemia
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0402)
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_1824
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) Undetected
Virus (HTLV-1) (-)
Isozyme LD, NP
STR(human) OK
Reference information Reference 3
User's Publication 8

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880  Koeffler, H P  Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications.  Blood  1983  62:709-21  PubMed ID: 6192859  
1937  Koeffler, H P, Golde, D W  Human myeloid leukemia cell lines: a review.  Blood  1980  56:344-50  PubMed ID: 6996765  
625  Koeffler, H P, Golde, D W  Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity.  Science  1978  200:1153-4  PubMed ID: 306682   DOI: 10.1126/science.306682

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User's Publication
21364  Yamanaka S, Furihata H, Yanagihara Y, Taya A, Nagasaka T, Usui M, Nagaoka K, Shoya Y, Nishino K, Yoshida S, Kosako H, Tanokura M, Miyakawa T, Imai Y, Shibata N, Sawasaki T.  Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation.  Nat Commun  2023  14(1):4683  PubMed ID: 37596276   DOI: 10.1038/s41467-023-40385-9
16840  Sameh A. Mohammed, Yasuhiro Kimura, Yuhki Toku, Yang Ju  Bioengineered PLEKHA7 nanodelivery regularly induces behavior alteration and growth retardation of acute myeloid leukemia  Biomaterials and Biosystems  2022  6:100045    DOI: 10.1016/j.bbiosy.2022.100045
20347  Katayama K, Nishihata A.  RSK inhibition induces apoptosis by downregulating protein synthesis in a variety of acute myeloid leukemia cell lines.  Biol Pharm Bull  2021    PubMed ID: 34602526   DOI: 10.1248/bpb.b21-00531
20437  Mahara A, Kitagawa K, Otaka A, Nakaoki T, Ishihara K, Yamaoka T.  Impact of REDV peptide density and its linker structure on the capture, movement, and adhesion of flowing endothelial progenitor cells in microfluidic devices.  Mater Sci Eng C Mater Biol Appl  2021  129:112381  PubMed ID: 34579900   DOI: 10.1016/j.msec.2021.112381
16209  Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada  KDM4B promotes acute myeloid leukemia associated with AML1-ETO by regulating chromatin accessibility  FASEB Bioadv   2021  3(12):1020-1033  PubMed ID: 34938963   DOI: 10.1096/fba.2021-00030
13354  Noura M, Morita K, Kiyose H, Matsuo H, Nishinaka-Arai Y, Kurokawa M, Kamikubo Y, Adachi S.  Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells.  Sci Rep  2020    PubMed ID: 33219287   DOI: 10.1038/s41598-020-76951-0
13842  Hsieh HY, Jia W, Jin ZC, Kidoya H, Takakura N.  High expression of PSF1 promotes drug resistance and cell cycle transit in leukemia cells  Cancer Sci  2020  111(7):2400-2412  PubMed ID: 32391593   DOI: 10.1111/cas.14452
6132  Naito H, Kidoya H, Sato Y, Takakura N.  Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.  J Biochem  2009  145(5):653-9  PubMed ID: 19179360   DOI: 10.1093/jb/mvp021

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