CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1902 : HSC-4]

3303 Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S. Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium. In Vitro Cell Dev Biol 1990 26:849-856 PubMed ID: 2228902 DOI: 10.1007/BF02624609

3089 Miyazaki K, Takaku H, Umeda M, Fujita T, Huang WD, Kimura T, Yamashita J, Horio T Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a Mycoplasma-infected cell line. Cancer Res 1990 50:4522-7 PubMed ID: 2164440

3248 Ichijo H, Momose F, Miyazono K Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells. Exp Cell Res 1990 187:263-9 PubMed ID: 2156718 DOI: 10.1016/0014-4827(90)90090-w

3243 Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas. J Oral Pathol Med 1989 18:391-5 PubMed ID: 2585303 DOI: 10.1111/j.1600-0714.1989.tb01570.x

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19774 Kasamatsu A, Nozaki R, Kawasaki K, Saito T, Minemura C, Seki N, Moss J, Uzawa K. Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma Cancers (Basel) 2024 16(6):1242 PubMed ID: 38539573 DOI: 10.3390/cancers16061242

21577 Al Awadh AA, Sakagami H, Amano S, Sayed AM, Abouelela ME, Alhasaniah AH, Aldabaan N, Refaey MS, Abdelhamid RA, Khalil HMA, Hamdan DI, Abdel-Sattar ES, Orabi MAA. In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations. Front Pharmacol 2024 15:1325272 PubMed ID: 38303989 DOI: 10.3389/fphar.2024.1325272

21608 Sakai R, Fujiwara K, Nagasaki-Maeoka E, Inagaki Y, Yamaoka B, Muto-Fujita E, Kamidaki Y, Koshinaga T, Uehara S, Takayama T, Sato S. Knockdown of TFAP2E results in rapid G2/M transition in oral squamous cell carcinoma cells. Oncol Lett 2024 27(3):128 PubMed ID: 38333638 DOI: 10.3892/ol.2024.14260

21664 Kina S, Miyamoto S, Kawabata-Iwakawa R, Kina-Tanada M, Ogawa M, Yokoo S. Higher overall survival rates of oral squamous cell carcinoma treated with metronomic neoadjuvant chemotherapy. Am J Cancer Res 2024 14(3):1033-1051 PubMed ID: 38590400 DOI: 10.62347/EYNT8387

21708 Inomata M, Abe M, Kawase Y, Hayashi T, Amano S, Sakagami H. Dectin-1/SYK Activation Induces Antimicrobial Peptide and Negative Regulator of NF-κB Signaling in Human Oral Epithelial Cells. In Vivo 2024 38(3):1042-1048 PubMed ID: 38688646 DOI: 10.21873/invivo.13537

21807 Takatsuka D, Tachinami H, Suzuki N, Yamazaki M, Yonesi A, Takaichi M, Imaue S, Yamada SI, Tanuma JI, Noguchi M, Tomihara K. PAK4 inhibition augments anti-tumour effect by immunomodulation in oral squamous cell carcinoma. Sci Rep 2024 14(1):14092 PubMed ID: 38890401 DOI: 10.1038/s41598-024-64126-0

21866 Tokizaki S, Podyma-Inoue KA, Matsumoto T, Takahashi K, Kobayashi M, Ibi H, Uchida S, Iwabuchi S, Harada H, Hashimoto S, Miyazono K, Shirouzu M, Watabe T. Inhibition of transforming growth factor-β signals suppresses tumor formation by regulation of tumor microenvironment networks Cancer Sci 2024 115(1):211-226 PubMed ID: 37972575 DOI: 10.1111/cas.16006

22052 Abé T, Yamazaki M, Nozumi M, Maruyama S, Takamura K, Ohashi R, Ajioka Y, Tanuma JI. Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved in cell migration and epithelial phenotype. Sci Rep 2024 14(1):22778 PubMed ID: 39354061 DOI: 10.1038/s41598-024-74041-z

19591 Kawasaki Y, Omori Y, Suzuki S, Yamada T. CD98hc as a marker of radiotherapy-resistant cancer stem cells in head and neck squamous cell carcinoma Arch Med Sci 2023 19(6):1859-1868 PubMed ID: 38058706 DOI: 10.5114/aoms.2020.92872

19747 Komatsuda H, Wakisaka R, Kono M, Kumai T, Hayashi R, Yamaki H, Sato R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Takahara M, Katada A, Kobayashi H. Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation Cancer Sci 2023 114(2):399-409 PubMed ID: 36285482 DOI: 10.1111/cas.15619

19748 Yamaki H, Kono M, Wakisaka R, Komatsuda H, Kumai T, Hayashi R, Sato R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Hayashi T, Kobayashi H, Katada A. Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer Cancer Immunol Immunother 2023 72(8):2799-2812 PubMed ID: 37173455 DOI: 10.1007/s00262-023-03460-0

19759 Takanori Takenawa, Koji Harada, Tarannum Ferdous, Keisuke Kawasaki, Yasuhiro Kuramitsu, Katsuaki Mishima Silencing of Tropomyosin 1 suppresses the proliferation, invasion and metastasis of oral squamous cell carcinoma in vitro Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023 35:282-287 DOI: 10.1016/j.ajoms.2022.10.004

19875 Abe T, Sakagami H, Amano S, Uota S, Bandow K, Uesawa Y, U S, Shibata H, Takemura Y, Kimura Y, Takao K, Sugita Y, Sato A, Tanuma SI, Takeshima H. A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs Medicines (Basel) 2023 10(7):43 PubMed ID: 37505064 DOI: 10.3390/medicines10070043

21082 Bessho T, Takagi T, Igawa K, Sato K. Gelatin-based cell culture device for construction and X-ray irradiation of a three-dimensional oral cancer model. Anal Sci 2023 PubMed ID: 36848001 DOI: 10.1007/s44211-023-00308-6

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

21527 Orabi MAA, Orabi EA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Sakagami H, Hatano T. New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines. Antioxidants (Basel) 2023 12(11) PubMed ID: 38001804 DOI: 10.3390/antiox12111951

20382 Fan M, Arai M, Tawada A, Chiba T, Fukushima R, Uzawa K, Shiiba M, Kato N, Tanzawa H, Takiguchi Y. Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers. Oncol Rep 2022 47(1) PubMed ID: 34738627 DOI: 10.3892/or.2021.8216

20513 Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y. Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma. Oncoimmunology 2022 11(1):2021619 PubMed ID: 35003900 DOI: 10.1080/2162402X.2021.2021619

20544 Matsuda R, Sakagami H, Amano S, Iijima Y, Sano M, Uesawa Y, Tamura N, Oishi Y, Takeshima H. Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid. Anticancer Res 2022 42(2):781-790 PubMed ID: 35093876 DOI: 10.21873/anticanres.15536

20551 Kono M, Yamaki H, Komatsuda H, Kumai T, Hayashi R, Wakisaka R, Sato R, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Harabuchi Y. IL-2 complex recovers steroid-induced inhibition in immunochemotherapy for head and neck cancer. Transl Oncol 2022 18:101358 PubMed ID: 35123188 DOI: 10.1016/j.tranon.2022.101358

20559 Komatsu M, Saito K, Miyamoto I, Koike K, Iyoda M, Nakashima D, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis. Oncol Lett 2022 23(2):49 PubMed ID: 34992682 DOI: 10.3892/ol.2021.13167

16203 Sasabe E, Tomomura A, Liu H, Sento S, Kitamura N, Yamamoto T. Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis Cancer Sci 2022 113(2):609-621 PubMed ID: 34874595 DOI: 10.1111/cas.15225

20648 Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H. Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives. Int J Mol Sci 2022 23(5) PubMed ID: 35269748 DOI: 10.3390/ijms23052601

20815 Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR. Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells. Medicines (Basel) 2022 9(6) PubMed ID: 35736248 DOI: 10.3390/medicines9060035

20838 Kobayashi M, Fujiwara K, Takahashi K, Yoshioka Y, Ochiya T, Podyma-Inoue KA, Watabe T. Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition. Inflamm Regen 2022 42(1):38 PubMed ID: 36057626 DOI: 10.1186/s41232-022-00225-7

20870 Takahashi K, Podyma-Inoue KA, Saito M, Sakakitani S, Sugauchi A, Iida K, Iwabuchi S, Koinuma D, Kurioka K, Konishi T, Tanaka S, Kaida A, Miura M, Hashimoto S, Okada M, Uchihashi T, Miyazono K, Watabe T. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3. Cell Rep 2022 40(13):111411 PubMed ID: 36170816 DOI: 10.1016/j.celrep.2022.111411

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20960 Zhang X, Han Y, Liu S, Guo B, Xu S, He Y, Liu L. MF-094 nanodelivery inhibits oral squamous cell carcinoma by targeting USP30. Cell Mol Biol Lett 2022 27(1):107 PubMed ID: 36474192 DOI: 10.1186/s11658-022-00407-8

20965 Morisaka H, Takaishi M, Akira S, Sano S. Keratinocyte Regnase-1, a down-regulator of skin inflammation, contributes to protection against tumor promotion by limiting COX-2 expression. J Invest Dermatol 2022 PubMed ID: 36470473 DOI: 10.1016/j.jid.2022.11.007

13361 Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T. Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines. Fitoterapia 2021 PubMed ID: 33246033 DOI: 10.1016/j.fitote.2020.104780

13462 Sawa Y, Ibaragi S, Okui T, Yamashita J, Ikebe T, Harada H. Expression of SARS-CoV-2 entry factors in human oral tissue J Anat 2021 Jan 9 PubMed ID: 33421967 DOI: 10.1111/joa.13391

20059 Kiguchi T, Kakihara Y, Yamazaki M, Katsura K, Izumi K, Tanuma JI, Saku T, Takagi R, Saeki M. Identification and characterization of R2TP in the development of oral squamous cell carcinoma. Biochem Biophys Res Commun 2021 548: 161-166 PubMed ID: 33640610 DOI: 10.1016/j.bbrc.2021.02.074

20085 Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H. Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Sci Rep 2021 11(1):5897 PubMed ID: 33723306 DOI: 10.1038/s41598-021-85242-1

20133 Nakamura A, Kakihara Y, Funayama A, Haga K, Mikami T, Kobayashi D, Yoshida Y, Izumi K, Kobayashi T, Saeki M. HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma. Biochem Biophys Res Commun 2021 557:294-301 PubMed ID: 33894417 DOI: 10.1016/j.bbrc.2021.04.021

14341 Kono M, Kumai T, Hayashi R, Yamaki H, Komatsuda H, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Kobayashi H, Harabuchi Y. Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery Cancer Immunol Immunother 2021 PubMed ID: 33866408 DOI: 10.1007/s00262-021-02940-5

15499 Kosaka A, Yajima Y, Hatayama M, Ikuta K, Sasaki T, Hirai N, Yasuda S, Nagata M, Hayashi R, Harabuchi S, Ohara K, Ohara M, Kumai T, Ishibashi K, Hirata-Nozaki Y, Nagato T, Oikawa K, Harabuchi Y, Celis E, Okumura T, Ohsaki Y, Kobayashi H, Ohkuri T. A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy Cancer Sci 2021 112(7):2705-2713 PubMed ID: 34009705 DOI: 10.1111/cas.14973

20350 Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI. Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression. Transl Oncol 2021 14(12):101236 PubMed ID: 34624685 DOI: 10.1016/j.tranon.2021.101236

15868 Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K. Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma Oncol Lett 2021 22(4):730 PubMed ID: 34429770 DOI: 10.3892/ol.2021.12991

20455 Harada K, Ferdous T, Mishima K. Efficacy of a Novel Oral Chemotherapeutic Agent, TAS-102, Against Human Oral Squamous Cell Carcinoma Cells. Anticancer Res 2021 41(12):6039-6049 PubMed ID: 34848458 DOI: 10.21873/anticanres.15423

16136 Harada K, Ferdous T, Watanabe K, Mizukami Y, Mishima K. Effects of an elemental diet, Elental®, may differ between healthy oral cells and oral cancer cells Oncol Rep 2021 45(2):738-751 PubMed ID: 33416174 DOI: 10.3892/or.2020.7896

16174 Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U. Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts Molecules 2021 26(23):7132 PubMed ID: 34885719 DOI: 10.3390/molecules26237132

16196 Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S. Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue Medicines (Basel) 2021 8(7):33 PubMed ID: 34206186 DOI: 10.3390/medicines8070033

16200 Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR. Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring Medicines (Basel) 2021 8(12):78 PubMed ID: 34940290 DOI: 10.3390/medicines8120078

16206 Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma Int J Mol Sci 2021 22(18):9947 PubMed ID: 34576110 DOI: 10.3390/ijms22189947

16211 Shyla Gopalakrishnan, Soumya Krishnan Uma, Gayathri Mohan, Amrutha Mohan, Geetha Shanmugam, Vineeth T. V. Kumar, Sreekumar J, Sivakumar K. Chandrika, Dileep Vasudevan, Sai Ravi Chandra Nori, Shijulal Nelson Sathi, Sanil George, Tessy Thomas Maliekal SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells Front Immunol 2021 12:740620 PubMed ID: 34867962 DOI: 10.3389/fimmu.2021.740620

16862 Kawasaki M, Sakabe T, Kodani I, Umekita Y. Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma Anticancer Res 2021 41(9):4563-4570 PubMed ID: 34475084 DOI: 10.21873/anticanres.15269

16975 Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K. Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Res 2021 41(4):1821-1830 PubMed ID: 33813387 DOI: 10.21873/anticanres.14948

11844 Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M. CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity. Oral Dis 2020 26(4):745-755 PubMed ID: 31603606 DOI: 10.1111/odi.13210

11965 Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T. The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. Lab. Invest. 2020 PubMed ID: 31857698 DOI: 10.1038/s41374-019-0357-z

12166 Yuichi Ohnishi Tsukasa Sakamoto Li Zhengguang Hiroki Yasui Hiroyuki Hamada Hirohito Kubo Masahiro Nakajima Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade Oncology Letter 2020 PubMed ID: 32391111 DOI: 10.3892/ol.2020.11523

13013 Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H. Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation. In Vivo 2020 PubMed ID: 32354886 DOI: 10.21873/invivo.11869

13093 Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. Protection of Bortezomib-induced Neurotoxicity by Antioxidants. Anticancer Res 2020 PubMed ID: 32620607 DOI: 10.21873/anticanres.14357

13205 Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H. Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro. Anticancer Res 2020 PubMed ID: 32878776 DOI: 10.21873/anticanres.14491

13401 Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. Oncoimmunology 2020 PubMed ID: 33457076 DOI: 10.1080/2162402X.2020.1856545

13524 Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T. TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation Cancer Sci 2020 111(7):2385-2399 PubMed ID: 32385953 DOI: 10.1111/cas.14455

13783 Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O. Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy Cancer Sci 2020 111(1):127-136. PubMed ID: 31692172 DOI: 10.1111/cas.14224

13903 Aika Tanzawa et al. Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma Oral Science International 2020 17(2):67-72 DOI: 10.1002/osi2.1044

11354 Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K. Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30587341 DOI: 10.1016/j.bbrc.2018.12.066

11620 Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H. Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives. Anticancer Res. 2019 PubMed ID: 31262875 DOI: 10.21873/anticanres.13497

9696 Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma Exp Cell Res 2019 384(2):111622 PubMed ID: 31518558 DOI: 10.1016/j.yexcr.2019.111622

9726 Mohamed A A Orabi, Esam A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl ( m-GO- m-GOG)-Type Ellagitannins From the Galls of Tamarix aphylla J Nat Prod 2019 82(10):2682-2695 PubMed ID: 31532650 DOI: 10.1021/acs.jnatprod.9b00073

9890 Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement J Cancer 2019 10(16):3728-3734 PubMed ID: 31333790 DOI: 10.7150/jca.32281

10427 Siti Aisyah Abd Ghafar, Ira Hazwani Hasan Fikri, Zolkapli Eshak Antioxidant Activity of Musa Paradisiaca(Banana) Soft Pith and Its Cytotoxicity Against Oral Squamous Carcinoma Cell Lines MJoSHT 2019 3(1):8-11

11907 Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Dis. Markers 2019 PubMed ID: 31019584 DOI: 10.1155/2019/8040361

11931 Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs. Anticancer Res. 2019 PubMed ID: 31810932 DOI: 10.21873/anticanres.13882

11933 Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones. Anticancer Res. 2019 PubMed ID: 31810912 DOI: 10.21873/anticanres.13862

12457 Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. SYT12 plays a critical role in oral cancer and may be a novel therapeutic target J Cancer 2019 10(20):4913-4920 PubMed ID: 31598163 DOI: 10.7150/jca.32582

12458 Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O. Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma Cancer Sci 2019 110(11):3453-3463 PubMed ID: 31444923 DOI: 10.1111/cas.14182

12459 Krishnan NM, Katoh H, Palve V, Pareek M, Sato R, Ishikawa S, Panda B. Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma PeerJ 2019 7:e6464 PubMed ID: 30842898 DOI: 10.7717/peerj.6464

12460 Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H. LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer Oncotarget 2019 10(10):1014-1030 PubMed ID: 30800215 DOI: 10.18632/oncotarget.26583

12586 Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner J Clin Biochem Nutr 2019 65(1):8-15 PubMed ID: 31379408 DOI: 10.3164/jcbn.18-91

10664 Ohnishi Y, Yasui H, Nozaki M, Nakajima M. Molecularly-targeted therapy for the oral cancer stem cells. Jpn Dent Sci Rev 2018 54:88-103 PubMed ID: 29755619 DOI: 10.1016/j.jdsr.2017.11.001

10682 Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. Biochem. Biophys. Res. Commun. 2018 495:2469-2474 PubMed ID: 29278705 DOI: 10.1016/j.bbrc.2017.12.138

10724 Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters. Anticancer Res. 2018 38:817-823 PubMed ID: 29374707 DOI: 10.21873/anticanres.12289

10806 Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp. Cell Res. 2018 367:112-118 PubMed ID: 29614312 DOI: 10.1016/j.yexcr.2018.03.041

10829 Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H. In Vitro Anti-tumor Activity of Azulene Amide Derivatives. In Vivo 2018 32:479-486 PubMed ID: 29695549 DOI: 10.21873/invivo.11264

11086 Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones. Anticancer Res. 2018 38(6):3283-3290 PubMed ID: 29848675 DOI: 10.21873/anticanres.12593

11110 Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants. In Vivo 2018 32(4):745-752 PubMed ID: 29936454 DOI: 10.21873/invivo.11303

11115 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(7):3897-3906 PubMed ID: 29970510 DOI: 10.21873/anticanres.12674

11148 Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives. Anticancer Res. 2018 38(8):4459-4467 PubMed ID: 30061210 DOI: 10.21873/anticanres.12748

11226 Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer 2018 PubMed ID: 30271493 DOI: 10.7150/jca.25666

4078 Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates Medicinal Chemistry Research 2018 27:2366–2378 DOI: 10.1007/s00044-018-2242-5

4401 Tamaki NAKANISHI and Koichi IMAI Interleukin-6, Matrix Metallopeptidase-9 Expression in Three-dimensional Tumor Microenvironment using Oral Cancer Cells Nano Biomedicine 2018 10, 77-82 DOI: 10.11344/nano.10.77

4402 Tamaki NAKANISHI, Kaname TSUJI, Yuki MATSUSHIMA, Koji YAMADA, Kazuhiro MATSUMOTO, Hiroaki YOSHIDA, Tomio ISEKI, Hideo SHIMIZU, Shosuke MORITA Interleukin-6 Expression in Three-dimensional Tumor Microenvironment using HSC-4 Cells Nano Biomedicine 2018 10, 21-25 DOI: 10.11344/nano.10.21

4173 Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H. In Vitro Antitumor Activity of Alkylaminoguaiazulenes. In Vivo 2018 PubMed ID: 29695558 DOI: 10.21873/invivo.11273

4183 Ohara K, Ohkuri T, Kumai T, Nagato T, Nozaki Y, Ishibashi K, Kosaka A, Nagata M, Harabuchi S, Ohara M, Oikawa K, Aoki N, Harabuchi Y, Celis E, Kobayashi H. Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma. Oncoimmunology 2018 PubMed ID: 30510853 DOI: 10.1080/2162402X.2018.1466771

4235 Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O. Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. Oncotarget 2018 PubMed ID: 30333913 DOI: 10.18632/oncotarget.26112

4237 Yamanouchi R, Harada K, Ferdous T, Ueyama Y. Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma. Mol Clin Oncol 2018 PubMed ID: 29456845 DOI: 10.3892/mco.2018.1548

4240 Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M. DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4. Arch. Oral Biol. 2018 PubMed ID: 29522917 DOI: 10.1016/j.archoralbio.2018.02.016

4241 Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI. Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma. Oncol. Rep. 2018 PubMed ID: 30132562 DOI: 10.3892/or.2018.6665

4242 Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y. Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. Int. J. Oncol. 2018 PubMed ID: 29115586 DOI: 10.3892/ijo.2017.4181

4243 Kinouchi M, Izumi S, Nakashiro KI, Haruyama Y, Kobashi G, Uchida D, Hasegawa T, Kawamata H. Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland? Int. J. Cancer 2018 PubMed ID: 30121960 DOI: 10.1002/ijc.31811

6022 Yakop F, Abd Ghafar SA, Yong YK, Saiful Yazan L, Mohamad Hanafiah R, Lim V, Eshak Z. Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines. Artif Cells Nanomed Biotechnol 2018 46(sup2):131-139 PubMed ID: 29561182 DOI: 10.1080/21691401.2018.1452750

14544 Yuichi OHNISHI, Hiroki YASUI, Kazutaka KIMURA, Masahiro WATANABE, Tomoko FUJII, Hiroyuki HAMADA, Yuri MUROI, Tomokazu MOTOHASHI, Hirohito KUBO, Masaki AKANE, Masayuki TSUNOKUMA, Masahiro NAKAJIMA Hepatocyte growth factor increases the invasive potential of human oral cancer cells Journal of Osaka Dental University 2018 52:69-74 DOI: 10.18905/jodu.52.1_69

16201 Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K. Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer Lab Invest 2018 98(8):980-988 PubMed ID: 29855544 DOI: 10.1038/s41374-018-0070-3

10148 Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Exp. Cell Res. 2017 352:357-363 PubMed ID: 28237246 DOI: 10.1016/j.yexcr.2017.02.026

10155 Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer. Sci Rep 2017 7:43379 PubMed ID: 28230172 DOI: 10.1038/srep43379

10191 Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem. Biophys. Res. Commun. 2017 486:385-390 PubMed ID: 28315328 DOI: 10.1016/j.bbrc.2017.03.050

10197 Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T. Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin. Anticancer Res. 2017 37:1023-1029 PubMed ID: 28314260 DOI: 10.21873/anticanres.11412

10201 Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Chalcones. Anticancer Res. 2017 37:1091-1098 PubMed ID: 28314269 DOI: 10.21873/anticanres.11421

10206 Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T. Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas. Molecules 2017 22: PubMed ID: 28294988 DOI: 10.3390/molecules22030470

10241 Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M. A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest. Chem. Pharm. Bull. 2017 65:365-372 PubMed ID: 28381677 DOI: 10.1248/cpb.c16-00830

10386 Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y. Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices. In Vivo 2017 31:591-598 PubMed ID: 28652425 DOI: 10.21873/invivo.11099

10418 Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis. J Cancer 2017 8:2033-2041 PubMed ID: 28819404 DOI: 10.7150/jca.18714

10572 Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Aurones. Anticancer Res. 2017 37:6169-6176 PubMed ID: 29061798 DOI: 10.21873/anticanres.12066

10576 Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters. Anticancer Res. 2017 37:6161-6168 PubMed ID: 29061797 DOI: 10.21873/anticanres.12065

10600 Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y. Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity. Int J Mol Sci 2017 18: PubMed ID: 29112119 DOI: 10.3390/ijms18112358

10961 HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin J Osaka Dent Univ 2017 51 : 1−8 DOI: 10.18905/jodu.51.1_1

11036 Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation Int J Cancer Oncol 2017 4: 225- 230 DOI: 10.15436/2377-0902.17.1628

4574 Yasui H, Ohnishi Y, Nakajima M, Nozaki M. Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation. Oncol Rep 2017 37(6):3674-3680 PubMed ID: 28440510 DOI: 10.3892/or.2017.5587

6029 Ishida S　et al Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis. Biochem Biophys Res Commun 2017 483(1):339-345 PubMed ID: 28017725 DOI: 10.1016/j.bbrc.2016.12.142

12679 Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K. Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Cancer Res 2017 77(9):2363-2374 PubMed ID: 28209617 DOI: 10.1158/0008-5472.CAN-16-2114

14638 Ohnishi Y, Yasui H, Kakudo K, Nozaki M. Regulation of cell migration via the EGFR signaling pathway in oral squamous cell carcinoma cells Oncol Lett 2017 13(2):930-936 PubMed ID: 28356980 DOI: 10.3892/ol.2016.5500

9584 Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H. Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline. In Vivo 2016 30:91-7 PubMed ID: 26912818

9616 Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer 2016 7:600-7 PubMed ID: 27053959 DOI: 10.7150/jca.13820

9630 Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma. J Cancer 2016 7:702-10 PubMed ID: 27076852 DOI: 10.7150/jca.14208

9676 Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A. Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production. Anticancer Res. 2016 36:2161-8 PubMed ID: 27127118

9694 Harada K, Ferdous T, Harada T, Ueyama Y. Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. Int. J. Oncol. 2016 49:276-84 PubMed ID: 27210058 DOI: 10.3892/ijo.2016.3523

9762 Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M. Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target. PLoS ONE 2016 11:e0159693 PubMed ID: 27441818 DOI: 10.1371/journal.pone.0159693

9808 Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H. Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone. In Vivo 2016 30:645-50 PubMed ID: 27566085

9892 Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y. Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones. Anticancer Res. 2016 36:5803-5812 PubMed ID: 27793902 DOI: 10.21873/anticanres.11164

9896 Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y. Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata. Anticancer Res. 2016 36:5931-5935 PubMed ID: 27793918 DOI: 10.21873/anticanres.11180

9911 Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H. Antiviral and Antitumor Activity of Licorice Root Extracts. In Vivo 2016 30:777-785 PubMed ID: 27815461 DOI: 10.21873/invivo.10994

9935 Suganya S AA, Kochurani KJ, Nair MG, Louis JM, Sankaran S, Rajagopal R, Kumar KS, Abraham P, P G B, Sebastian P, Somananthan T, Maliekal TT. TM1-IR680 peptide for assessment of surgical margin and lymph node metastasis in murine orthotopic model of oral cancer. Sci Rep 2016 6:36726 PubMed ID: 27827443 DOI: 10.1038/srep36726

5809 Ninomiya K et al Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines. J Nat Med 2016 70(3):435-51 PubMed ID: 27178360 DOI: 10.1007/s11418-016-0998-9

5810 Kitagawa N et al The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines. Int J Mol Sci 2016 17(12). pii: E1979 PubMed ID: 27898032 DOI: 10.3390/ijms17121979

6032 Tada H, Shimizu T, Nagaoka I, Takada H. Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res 2016 37(3):199-205 PubMed ID: 27356607 DOI: 10.2220/biomedres.37.199

6033 Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R. Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. Int J Oncol 2016 48(4):1670-8 PubMed ID: 26893131 DOI: 10.3892/ijo.2016.3391

6036 Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer. Int J Oncol. 2016 48(2):607-12 PubMed ID: 26718916 DOI: 10.3892/ijo.2015.3305

6042 Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa Cavin-2 in oral cancer: A potential predictor for tumor progression. Mol Carcinog 2016 55(6):1037-47 PubMed ID: 26086332 DOI: 10.1002/mc.22347

13988 Ishibashi K, Kumai T, Ohkuri T, Kosaka A, Nagato T, Hirata Y, Ohara K, Oikawa K, Aoki N, Akiyama N, Sado M, Kitada M, Harabuchi Y, Celis E, Kobayashi H. Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy Oncoimmunology 2016 5(6):e1169356 PubMed ID: 27471649 DOI: 10.1080/2162402X.2016.1169356

14162 Yamali C, Gul HI, Sakagami H, Supuran CT. Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases J Enzyme Inhib Med Chem 2016 31(sup4):125-131 PubMed ID: 27594305 DOI: 10.1080/14756366.2016.1221825

14178 Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T. Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra J Nat Prod 2016 79(4):984-95 PubMed ID: 26938659 DOI: 10.1021/acs.jnatprod.5b01065

7109 Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K. Telomerase activity in the occurrence and progression of oral squamous cell carcinoma. J Oral Sci 2015 57:295-303 PubMed ID: 26666852 DOI: 10.2334/josnusd.57.295

7175 Ohnishi Y, Yasui H, Kakudo K, Nozaki M. Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway. Int. J. Oncol. 2015 47:2165-72 PubMed ID: 26497980 DOI: 10.3892/ijo.2015.3215

7196 Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y. Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes. Anticancer Res. 2015 35:5299-307 PubMed ID: 26408690

7283 Uzawa K, Kasamatsu A, Baba T, Kimura Y, Nakashima D, Higo M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H. Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer. Int. J. Oncol. 2015 47:1077-83 PubMed ID: 26179426 DOI: 10.3892/ijo.2015.3083

5422 Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5. Quantitative Structure-Cytotoxicity Relationship of Oleoylamides. Anticancer Res 2015 5(10):5341-51 PubMed ID: 26408695

6043 Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y. Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells. Toxicol Rep 2015 2:1281-1290 PubMed ID: 28962471 DOI: 10.1016/j.toxrep.2015.09.009

6044 Kasama H　et al Adenosine A2b receptor promotes progression of human oral cancer. BMC Cancer 2015 15:563 PubMed ID: 26228921 DOI: 10.1186/s12885-015-1577-2

6051 Okamoto A　et al Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma. PLoS One 2015 10(11):e0142252 PubMed ID: 26554377 DOI: 10.1371/journal.pone.0142252

6052 Saito T et al Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis. PLoS One 2015 10(9):e0137923 PubMed ID: 26378920 DOI: 10.1371/journal.pone.0137923

6053 Miyamoto I et al Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth. Biochem Biophys Rep 2015 3:26-31 PubMed ID: 29124166 DOI: 10.1016/j.bbrep.2015.07.008

6054 Baba T et al Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway. Mol Carcinog 2015 54(8):608-17 PubMed ID: 24375483 DOI: 10.1002/mc.22127

14987 Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H. Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression Oncotarget 2015 6(32):33345-57 PubMed ID: 26452260 DOI: 10.18632/oncotarget.5428

15042 Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer Cancer Med 2015 4(5):759-69 PubMed ID: 25644496 DOI: 10.1002/cam4.418

15057 Ohmura G, Tsujikawa T, Yaguchi T, Kawamura N, Mikami S, Sugiyama J, Nakamura K, Kobayashi A, Iwata T, Nakano H, Shimada T, Hisa Y, Kawakami Y. Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC Mol Cancer Res 2015 13(4):721-31 PubMed ID: 25421751 DOI: 10.1158/1541-7786.MCR-14-0410

15186 Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma Oncoimmunology 2015 4(2):e976077 PubMed ID: 25949874 DOI: 10.4161/2162402X.2014.976077

10985 Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H. Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma Sci Rep 2015 5:16280 PubMed ID: 26538233 DOI: 10.1038/srep16280

6056 Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y. Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics. Anticancer Res 2014 34(8):4117-20 PubMed ID: 25075037

6023 Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M. NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma. Oncol Lett 2014 7(1):35-40 PubMed ID: 24348816 DOI: 10.3892/ol.2013.1690

5916 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells. In Vivo 2014 28(4):549-56 PubMed ID: 24982221

5859 Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC. Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma. Biomed Res. 2014 35(6):381-8 PubMed ID: 25743344 DOI: 10.2220/biomedres.35.381

5807 Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H. Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells. In Vivo 2014 28(5):895-907 PubMed ID: 25189906

5659 Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of 3-styrylchromones. Anticancer Res 2014 34(10):5405-11 PubMed ID: 25275035

5544 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of phenylpropanoid amides. Anticancer Res 2014 34(7):3543-8 PubMed ID: 24982367

5337 Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H. Quantitative structure-cytotoxicity relationship of piperic acid amides. Anticancer Res 2014 34(9):4877-84 PubMed ID: 25202069

5307 Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor. J Transl Med 2014 12:265 PubMed ID: 25240937 DOI: 10.1186/s12967-014-0265-3

16010 Fukumoto C, Nakashima D, Kasamatsu A, Unozawa M, Shida-Sakazume T, Higo M, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice Oncoscience 2014 1(12):807-20 PubMed ID: 25621296 DOI: 10.18632/oncoscience.101

5190 Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H. Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4. Acta Med Okayama 2013 67(3):153-64 PubMed ID: 23804138 DOI: 10.18926/AMO/50408

5122 Iida S, Shimada J, Sakagami H. Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines. In Vivo 2013 27(3):321-32 PubMed ID: 23606687

5110 Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M. Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. Anticancer Res 2013 33(8):3061-8 PubMed ID: 23898061

5057 Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y. Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma. Int J Cancer. 2013 132(12):2755-66 PubMed ID: 23180648 DOI: 10.1002/ijc.27966

5028 Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol 2013 139(4):585-94 PubMed ID: 23242234 DOI: 10.1007/s00432-012-1361-5

6067 Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K. High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer. Int J Oncol 2013 42(1):141-50 PubMed ID: 23123766 DOI: 10.3892/ijo.2012.1677

6070 Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013 139(4):533-42 PubMed ID: 23207790 DOI: 10.1007/s00432-012-1356-2

6072 Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One 2013 8(2):e56381 PubMed ID: 23418564 DOI: 10.1371/journal.pone.0056381

6074 Shimizu F1, Shiiba M2, Ogawara K3, Kimura R1, Minakawa Y1, Baba T1, Yokota S, Nakashima D1, Higo M3, Kasamatsu A3, Sakamoto Y3, Tanzawa H4, Uzawa K4. Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer. PLoS One 2013 8(12):e83187 PubMed ID: 24386158 DOI: 10.1371/journal.pone.0083187

6076 Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Kinesin family member 4A: a potential predictor for progression of human oral cancer. PLoS One. 2 2013 8(12):e85951 PubMed ID: 24386490 DOI: 10.1371/journal.pone.0085951

6077 Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma. J Oral Pathol Med 2013 42(2):133-9 PubMed ID: 22672247 DOI: 10.1111/j.1600-0714.2012.01182.x

6078 Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K. Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J 2013 30(6):585-97 PubMed ID: 23242548 DOI: 10.1007/s10719-012-9458-2

6083 Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy. Br J Cancer 2013 109(8):2155-66 PubMed ID: 24045666 DOI: 10.1038/bjc.2013.577

15086 Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H. Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells Oncol Rep 2013 29(4):1349-55 PubMed ID: 23354949 DOI: 10.3892/or.2013.2251

7722 Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K. Comprehensive epigenetic analysis using oral rinse samples: a pilot study. J. Oral Maxillofac. Surg. 2012 70:1486-94 PubMed ID: 21821326 DOI: 10.1016/j.joms.2011.04.021

6087 Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K. Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines. J Oral Sci 2012 54(1):71-5 PubMed ID: 22466889 DOI: 10.2334/josnusd.54.71

6088 Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H. Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness. J Pathol 2012 228(2):181-92 PubMed ID: 22262311 DOI: 10.1002/path.3993

6089 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines. J Oral Sci 2012 54(3):241-50 PubMed ID: 23047035 DOI: 10.2334/josnusd.54.241

6094 Yuichi Ohnishi　et al Analysis of a cancer stem cell marker EpCAM in an oral squamous cell carcinoma cell line as monolayers and multicellular aggregates Journal of Osaka Dental University 2012 46:215-220 DOI: 10.18905/jodu.46.2_215

6095 Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H. Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma. Oncol Lett 2012 3(2):273-280 PubMed ID: 22740894 DOI: 10.3892/ol.2011.473

6098 Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K. Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity. Tumour Biol 2012 33(1):183-94 PubMed ID: 22081310 DOI: 10.1007/s13277-011-0261-7

15671 Harada T, Harada K, Ueyama Y. The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma Int J Oncol 2012 41(2):565-72 PubMed ID: 22664937 DOI: 10.3892/ijo.2012.1501

7601 Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H. Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives. Anticancer Res. 2011 31:4231-8 PubMed ID: 22199286

6109 Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M. A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions. Int J Oncol 2011 39(6):1401-5 PubMed ID: 21785818 DOI: 10.3892/ijo.2011.1137

6111 Hiroshi Inoue, Yuichi Ohnishi, Masahiro Watanabe, Tomoko Fujii, Yuki Minamino, Yoshihide Ugaki, Suguru Dateoka, Mitsuchika Sugitatsu, Masayuki Tsunokuma, Hirohito Kubo, Masahiro Nakajima, Kenji Kakudo Effect of EpCAM localization on proliferation of an oral squamous cell carcinoma cell line Journal of Osaka Dental UniversityJournal of Osaka Dental University 2011 45:259-264 DOI: 10.18905/jodu.45.2_259

6112 lHiroshi Inoue et al Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines Asian Journal of Oral and Maxillofacial Surgery 2011 23:1-6 DOI: 10.1016/j.ajoms.2010.10.001

6116 Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H. Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells. Oncol Rep 2011 25(3):795-802 PubMed ID: 21206983 DOI: 10.3892/or.2010.1130

6118 Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer Journal of Osaka Dental University 2011 45：31-36 DOI: 10.18905/jodu.45.1_31

8085 Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T. Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder. In Vivo 2010 24:735-43 PubMed ID: 20952742

18753 Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K, Itoh H. Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC Oncol Rep 2010 23(6):1625-33 PubMed ID: 20428818 DOI: 10.3892/or_00000804

19126 Shintani S, Hamakawa H, Nakashiro K, Shirota T, Hatori M, Tanaka M, Kuroshita Y, Kurokawa Y. Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral squamous cell carcinoma Int J Oral Maxillofac Surg 2010 39(11):1115-9 PubMed ID: 20709497 DOI: 10.1016/j.ijom.2010.02.027

5611 Wakabayashi H, Narita T, Suga A, Sakagami H. Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives. In Vivo 2010 24(1):39-44 PubMed ID: 20133973

6120 Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Biochem Biophys Res Commun 2010 391(4):1785-91 PubMed ID: 20045673 DOI: 10.1016/j.bbrc.2009.12.156

6122 Nomi N, Kodama S, Suzuki M. Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway. Oncol Rep 2010 24(1):225-31 PubMed ID: 20514466 DOI: 10.3892/or_00000850

6123 Yuji Miyazaki　et al Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer J Cancer Sci Ther 2010 2(2) :26-32

8490 Saitoh Y, Yoshimura Y, Nakano K, Miwa N. Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells. Exp. Oncol. 2009 31:156-62 PubMed ID: 19783965

8558 Ozawa H, Mutai H, Matsunaga T, Tokumaru Y, Fujii M, Sakamoto K, Tomita T, Ogawa K. Promoted cell proliferation by connexin 30 gene transfection to head-and-neck cancer cell line. Anticancer Res. 2009 29:1981-5 PubMed ID: 19528455

6127 Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H. Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines. Anticancer Res 2009 29(8):3079-86 PubMed ID: 19661319

6128 Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A. Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure. Anticancer Res 2009 29(1):455-64 PubMed ID: 19331186

6129 Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H. Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives. Anticancer Res 2009 29(4):1123-30 PubMed ID: 19414354

18691 Shimizu M, Imai M. Effect of the antibody immunotherapy by the anti-MUC1 monoclonal antibody to the oral squamous cell carcinoma in vitro Biol Pharm Bull 2008 31(12):2288-93 PubMed ID: 19043215 DOI: 10.1248/bpb.31.2288

6136 Okamura M, Shimada J, Sakagami H. Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines. Anticancer Res 2008 28(1A):253-9 PubMed ID: 18383853

6138 Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines. Anticancer Res 2008 28(2A):1069-78 PubMed ID: 18507056

6141 Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I. Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma. Cancer Sci 2008 99(7):1390-400 PubMed ID: 18452558 DOI: 10.1111/j.1349-7006.2008.00838.x

6143 Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H. Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines. Anticancer Res. 2007 27(1A):133-43 PubMed ID: 17352225

6148 Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H. Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines. Anticancer Res 2006 26(3A):1917-23 PubMed ID: 16827125

6150 Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene 2006 25(8):1216-24 PubMed ID: 16247456 DOI: 10.1038/sj.onc.1209158