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20483
Koide R, Hirane N, Kambe D, Yokoi Y, Otaki M, Nishimura SI.
Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis.
Biomaterials
2022
280:121314
PubMed ID: 34906850
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16114
Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK.
Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts
Cell Biol Toxicol
2022
Mar 15
PubMed ID: 33723743
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16273
Sakai S, Kotani T, Harada R, Goto R, Morita T, Bouissil S, Dubessay P, Pierre G, Michaud P, El Boutachfaiti R, Nakahata M, Kojima M, Petit E, Delattre C.
Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks
Carbohydr Polym
2022
277:118820
PubMed ID: 34893237
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20613
Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.
Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.
Analyst
2022
PubMed ID: 35297918
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16644
Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.
Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System
Cells
2022
11(10):1677
PubMed ID: 35626714
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13179
Hayakawa EH, Kato H, Nardone GA, Usukura J.
A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells.
Parasitol Int
2021
PubMed ID: 32853776
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13396
Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.
Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis.
Biochem Biophys Rep
2021
PubMed ID: 33392396
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13418
Abiko Y, Aoki H, Kumagai Y.
Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome.
Toxicol Appl Pharmacol
2021
PubMed ID: 33428920
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20024
Yamazaki T, Tokiwa T.
Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.
Hum Cell
2021
PubMed ID: 33495943
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20049
Abiko Y, Katayama Y, Akiyama M, Kumagai Y.
Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts.
Food Chem Toxicol
2021
150:112061
PubMed ID: 33587975
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20081
Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.
The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.
Oncotarget
2021
12(4):333-343
PubMed ID: 33659044
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20119
Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H.
Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication.
Commun Biol
2021
4(1):425
PubMed ID: 33782534
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20166
Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.
CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.
Hepatol Commun
2021
5(2):334-348
PubMed ID: 33553979
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20204
Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C.
Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells.
Monoclon Antib Immunodiagn Immunother
2021
40(3):118-123
PubMed ID: 34076498
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20281
Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M.
Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten.
J Food Sci Technol
2021
58(9):3504-3513
PubMed ID: 34366467
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20288
Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y.
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Int J Mol Sci
2021
22(6)
PubMed ID: 33799598
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20384
Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.
Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.
Mol Pharm
2021
PubMed ID: 34734526
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20502
Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K.
PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.
Cells
2021
10(12)
PubMed ID: 34944058
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16205
Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.
Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway
J Nutr Biochem
2021
89:108573
PubMed ID: 33388347
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16370
Enokiya T, Nishikawa K, Hamada Y, Ikemura K, Sugimura Y, Okuda M.
Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene
Basic Clin Pharmacol Toxicol
2021
128(3):525-533
PubMed ID: 33248001
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16372
Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai
Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment
Journal of Crystal Growth
2021
572:126265
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20621
Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.
J Toxicol Sci
2021
46(12):569-587
PubMed ID: 34853243
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12057
Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.
Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver.
Biochim Biophys Acta Mol Basis Dis
2020
PubMed ID: 32088316
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12094
Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H.
Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet.
Tissue Eng Part C Methods
2020
PubMed ID: 32186996
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12198
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
Nature Communications
2020
11:5292
PubMed ID: 33087715
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12439
Fujiyama Y, Kumamoto Y, Nishizawa N, Nakamoto S, Harada H, Yokota K, Tanaka Y, Igarashi K, Oiki H, Okuwaki K, Iwai T, Kajita S, Takahashi H, Tajima H, Kaizu T, Sasaki J, Watanabe M, Yamashita K.
Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN)
Ann Surg Oncol
2020
27(10):4007-4016
PubMed ID: 32144623
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12963
Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M.
Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation.
ACS Omega
2020
PubMed ID: 32905425
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13027
Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T.
Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells.
In Vitro Cell Dev Biol Anim
2020
PubMed ID: 32394241
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13053
Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ.
TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells.
Cell Death Dis
2020
PubMed ID: 32471991
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13073
Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.
Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.
Free Radic Biol Med
2020
PubMed ID: 32553752
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13103
Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J.
Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.
NPJ Precis Oncol
2020
PubMed ID: 32656360
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13189
Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y.
A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract.
Food Chem Toxicol
2020
PubMed ID: 32871193
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13191
Xu DQ, Yuan XJ, Hirayama M, Toyoda H.
Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway.
In Vivo
2020
PubMed ID: 32871763
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13241
Yamashita R, Komaki Y, Yang G, Ibuki Y.
Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.
Mutat Res
2020
PubMed ID: 33198939
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13290
Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H.
Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential.
Sci Rep
2020
PubMed ID: 33060804
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13528
Ishizawa K, Togami K, Tada H, Chono S.
Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers
J Pharm Sci
2020
109(12):3608-3616
PubMed ID: 32926888
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13635
Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K.
Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system
Xenobiotica
2020
50(6):654-662
PubMed ID: 31631733
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14866
Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I.
Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver
Mol Pharm
2020
17(8):2821-2830
PubMed ID: 32602343
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5357
Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.
AUTACs: Cargo-Specific Degraders Using Selective Autophagy.
Mol Cell
2019
76(5):797-810
PubMed ID: 31606272
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11522
Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H.
Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.
J. Cell. Physiol.
2019
PubMed ID: 30993729
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11538
Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.
Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.
Neoplasia
2019
PubMed ID: 31042624
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11857
Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y.
Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists.
Molecules
2019
PubMed ID: 31137814
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6837
Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S.
Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.
Anticancer Agents Med Chem
2019
19(13):1651-1657
PubMed ID: 31038081
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9758
Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai
Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line
Oncol Lett
2019
17(2):2431-2440
PubMed ID: 30719114
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9759
Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito
Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells
Fundamental Toxicological Sciences
2019
6 :281-286
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9763
Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita
Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells
Biochem Biophys Res Commun
2019
509(1):268-274
PubMed ID: 30583860
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11906
Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
J Pharm Pharm Sci
2019
PubMed ID: 31804920
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11048
Yuta Kurashina, Ryo Sato, Hiroaki Onoe
Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly
APL Bioeng
2019
3(4):046101
PubMed ID: 31737859
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11057
Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda
Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein
Sci Rep
2019
9(1):20359
PubMed ID: 31889141
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12238
Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond
Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy
Anal Chem
2019
91(4):2710-2718
PubMed ID: 30664349
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12365
Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K.
Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro
Drug Metab Pharmacokinet
2019
34(4):272-279
PubMed ID: 31280915
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12443
Kojima K, Nakamura T, Ooizumi Y, Igarashi K, Tanaka T, Yokoi K, Ishii S, Nishizawa N, Katoh H, Kosaka Y, Sato T, Watanabe M, Yamashita K.
Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer
PLoS One
2019
14(1):e0211108
PubMed ID: 30677088
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12444
Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T.
Plasmodium RON12 localizes to the rhoptry body in sporozoites
Parasitol Int
2019
68(1):17-23
PubMed ID: 30290224
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12445
Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T.
Glass-based organ-on-a-chip device for restricting small molecular absorption
J Biosci Bioeng
2019
127(5):641-646
PubMed ID: 30473393
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12472
Hara M, Takeba Y, Iiri T, Ohta Y, Ootaki M, Watanabe M, Watanabe D, Koizumi S, Otsubo T, Matsumoto N.
Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway
Cancer Sci
2019
110(1):235-244
PubMed ID: 30390393
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12517
Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)
Nat Prod Res
2019
33(2):189-195
PubMed ID: 29457741
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10634
Hara J, Tanaka Y, Kaneko H, Itoh Y, Ikegaya H.
Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains.
Arch. Virol.
2018
163:633-637
PubMed ID: 29198036
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10641
Kaji K, Nishimura N, Seki K, Sato S, Saikawa S, Nakanishi K, Furukawa M, Kawaratani H, Kitade M, Moriya K, Namisaki T, Yoshiji H.
Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake.
Int. J. Cancer
2018
142:1712-1722
PubMed ID: 29205334
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10660
Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M.
β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.
Environ Sci Pollut Res Int
2018
25:6320-6328
PubMed ID: 29247416
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10774
Yajima Y, Lee CN, Yamada M, Utoh R, Seki M.
Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers.
J. Biosci. Bioeng.
2018
126(1):111-118
PubMed ID: 29502942
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10786
He Q, Okajima T, Onoe H, Subagyo A, Sueoka K, Kuribayashi-Shigetomi K.
Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures.
Sci Rep
2018
8:4556
PubMed ID: 29540810
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10847
Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K.
Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.
PLoS ONE
2018
13:e0194785
PubMed ID: 29746493
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|
11025
Isolation of activating factors of serotonin N-acetyltransferase from rice peptides
Journal of Functional Foods
2018
41, 148-154
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11089
Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S.
Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides.
PLoS ONE
2018
13(6):e0198264
PubMed ID: 29856876
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11139
Saikawa S, Kaji K, Nishimura N, Seki K, Sato S, Nakanishi K, Kitagawa K, Kawaratani H, Kitade M, Moriya K, Namisaki T, Mitoro A, Yoshiji H.
Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein.
Cancer Lett.
2018
434:120-129
PubMed ID: 30031758
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11113
Kawai T, Ota N, Imasato A, Shirasaki Y, Otsuka K, Tanaka Y.
Profiling of N-linked glycans from 100 cells by capillary electrophoresis with large-volume dual preconcentration by isotachophoresis and stacking.
J Chromatogr A
2018
1565:138-144
PubMed ID: 29945790
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11160
Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O.
In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana.
J Evid Based Integr Med
2018
PubMed ID: 30088418
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11292
Hori T, Kurosawa O.
A Three-dimensional Cell Culture Method with a Micromesh Sheet and Its Application to Hepatic Cells.
Tissue Eng Part C Methods
2018
PubMed ID: 30412042
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4452
Phoebe Trio1, Atsuyoshi Kawahara, Satoru Fujisaki, De-Xing Hou
Comparative Gene Expression Profiling in Cultured Cell Lines after Treatment with Wasabi-derived Isothiocyanates
KIMIKA
2018
29, 1-10
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4224
Sultana H, Watanabe K, Rana MM, Takashima R, Ohashi A, Komai M, Shirakawa H.
Effects of Vitamin K₂ on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR.
Nutrients
2018
PubMed ID: 30060524
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4225
Takashima Y, Horisawa K, Udono M, Ohkawa Y, Suzuki A.
Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors.
Cancer Sci.
2018
PubMed ID: 30220099
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4483
Anusornvongchai T, Nangaku M, Jao TM, Wu CH, Ishimoto Y, Maekawa H, Tanaka T, Shimizu A, Yamamoto M, Suzuki N, Sassa R, Inagi R.
Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response.
Kidney Int.
2018
94(3):536-550
PubMed ID: 29887316
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4484
Wang S, Fumoto S, Miyamoto H, Tanaka M, Nishida K.
Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice.
Int J Pharm
2018
548(1):173-181
PubMed ID: 29969708
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14907
Takiguchi S, Ayaori M, Yakushiji E, Nishida T, Nakaya K, Sasaki M, Iizuka M, Uto-Kondo H, Terao Y, Yogo M, Komatsu T, Ogura M, Ikewaki K.
Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways
Arterioscler Thromb Vasc Biol
2018
38(7):1454-1467
PubMed ID: 29748333
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9988
Li S, Gao A, Dong S, Chen Y, Sun S, Lei Z, Zhang Z.
Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta.
Int. J. Biol. Macromol.
2017
96:26-34
PubMed ID: 27939510
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10080
Wakuri S, Yamakage K, Kazuki Y, Kazuki K, Oshimura M, Aburatani S, Yasunaga M, Nakajima Y.
Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase.
Anal. Biochem.
2017
522:18-29
PubMed ID: 28111305
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10167
Takahashi K, Suzuki N, Ogra Y.
Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.
Int J Mol Sci
2017
18:
PubMed ID: 28245633
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10236
Sudo K, Niikura K, Iwaki K, Kohyama S, Fujiwara K, Doi N.
Human-derived fusogenic peptides for the intracellular delivery of proteins.
J Control Release
2017
255:1-11
PubMed ID: 28385674
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10351
Nakashima KI, Ogiwara T, Hirai T, Tanaka T, Murata H, Kaburagi K, Fujii-Kuriyama Y, Hayashi H, Inoue M.
Gerontoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist.
Bioorg. Med. Chem.
2017
25:4253-4258
PubMed ID: 28662965
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10392
Ono Y, Tomimori N, Hori H, Kitagawa Y, Shibata H.
Mechanisms of chromosomal aberrations induced by sesamin metabolites in Chinese hamster lung cells.
Mutat. Res.
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Tung NH, Uto T, Hai NT, Li G, Shoyama Y.
Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines.
Pharmacogn Mag
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Chen Z, Wu Y, Ma YS, Kobayashi Y, Zhao YY, Miura Y, Chiba H, Hui SP.
Profiling of cardiolipins and their hydroperoxides in HepG2 cells by LC/MS.
Anal Bioanal Chem
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Machihara K, Tanaka H, Hayashi Y, Murakami I, Namba T.
Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78.
Biochem. Biophys. Res. Commun.
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Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J.
Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.
Sci Rep
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Fukushima T, Hara-Yamamura H, Nakashima K, Tan LC, Okabe S.
Multiple-endpoints gene alteration-based (MEGA) assay: A toxicogenomics approach for water quality assessment of wastewater effluents.
Chemosphere
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Oda Y, Hidaka M, Suzuki A.
Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells.
Biol. Pharm. Bull.
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Inoue C, Zhao C, Tsuduki Y, Udono M, Wang L, Nomura M, Katakura Y.
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NPJ Aging Mech Dis
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Toda M, Totoki T, Nakamura C, Yasuma T, D' Alessandro-Gabazza CN, Mifuji-Moroka R, Nishihama K, Iwasa M, Horiki N, Gabazza EC, Takei Y.
Low dose of alcohol attenuates pro-atherosclerotic activity of thrombin.
Atherosclerosis
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265:215-224
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Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.
Sake lees hydrolysate protects against acetaminophen-induced hepatotoxicity via activation of the Nrf2 antioxidant pathway.
J Clin Biochem Nutr
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Zhou Y, Fukuda T, Hang Q, Hou S, Isaji T, Kameyama A, Gu J.
Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation.
Sci Rep
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Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, Yamana Y, Fujita K, Sakamoto T, Nomura T, Yoneyama H, Kobara H, Mori H, Iwama H, Okano K, Suzuki Y, Masaki T.
Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest.
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Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.
Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.
Am. J. Chin. Med.
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Igarashi K, Yamashita K, Katoh H, Kojima K, Ooizumi Y, Nishizawa N, Nishiyama R, Kawamata H, Tajima H, Kaizu T, Kumamoto Y, Watanabe M.
Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease.
PLoS ONE
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Cell Sheet Fabrication Using RGD Peptide-Coupled Alginate Hydrogels Fabricated by an Electrodeposition Method
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Induction of Drug Resistance in Human Hepatoma Cells Cultured on a Silicate Fiber-Based 3D Scaffold
Adv Biochem Biotechnol
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Collagen Microparticle-mediated 3D Cell Organization: A Facile Route to Bottom-Up Engineering of Thick and Porous Tissues
ACS Biomater. Sci. Eng.
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CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element
Fundamental Toxicological Sciences
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Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
A New Sarasinoside Congener, Sarasinoside M 2, From a Marine Sponge Collected in the Solomon Islands
Biosci Biotechnol Biochem
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Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori
Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells
Int J Oncol
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Yoshihiko Kihara, Riho Maeda, Azusa Imaizumi, Tsukasa Ichikawa, Nobukatsu Nemoto, Tsutomu Ishihara, Nobutaka Hirano, and Mitsuru Haruki
Alkyne-Functionalized Cationic Polysiloxane Polymers Conjugated with Targeting Molecules by Click Reactions for DNA Delivery
Journal of Nanoscience and Nanotechnology
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Uchiyama T, Ota H, Itaya-Hironaka A, Shobatake R, Yamauchi A, Sakuramoto-Tsuchida S, Makino M, Kimura H, Takeda M, Ohbayashi C, Takasawa S.
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DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells
Nutr Cancer
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Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
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Int J Oncol
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J Am Chem Soc
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Drug Metab. Pharmacokinet.
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Chem. Pharm. Bull.
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Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system.
Microbes Infect.
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Anchoring PEG-oleate to cell membranes stimulates reactive oxygen species production.
Colloids Surf B Biointerfaces
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Molecular hydrogen suppresses activated Wnt/β-catenin signaling.
Sci Rep
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δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.
Food Funct
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Tanaka Y, Tateishi K, Nakatsuka T, Kudo Y, Takahashi R, Miyabayashi K, Yamamoto K, Asaoka Y, Ijichi H, Tateishi R, Shibahara J, Fukayama M, Ishizawa T, Hasegawa K, Kokudo N, Koike K.
Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression.
Oncogenesis
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Bioactive Compounds from the Leaves of Lumnitzera racemosa against Acetaminophen-induced Liver damage in vitro
Journal of Arid Land Studies
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Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line.
Front Pharmacol
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Kung-Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying-Chu Lin, Ming-Ho Tsai, Kenly Wuputra, Yen-Liang Lee, Chia-Chen Ku, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Chun-Chieh Wu, Chee-Yin Chai, Richard Eckner, Chen-Lung Steve Lin, Sophie S-W Wang, Deng-Chyang Wu, Chang-Shen Lin, Kazunari K Yokoyama
Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer
Stem Cells
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34(11):2613-2624
PubMed ID: 27341307
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12644
Minatani N, Waraya M, Yamashita K, Kikuchi M, Ushiku H, Kojo K, Ema A, Nishimiya H, Kosaka Y, Katoh H, Sengoku N, Tanino H, Sidransky D, Watanabe M.
Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer
PLoS One
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11(1):e0144862
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Kawauchi S, Nakamura T, Horibe S, Tanahashi T, Mizuno S, Hamaguchi T, Rikitake Y.
Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers
Biopharm Drug Dispos
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37(9):522-532
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Liu Y, Sakai S, Taya M.
Engineering tissues with a perfusable vessel-like network using endothelialized alginate hydrogel fiber and spheroid-enclosing microcapsules
Heliyon
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2(2):e00067
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14088
Yoshitaka Koseki, Yoshikazu Ikuta, Takaaki Kamishima, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai
Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of Nano-Prodrug
Bulletin of the Chemical Society of Japan
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Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.
Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma
Cancer Res
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76(11):3265-76
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Kazuya Furusawa, Masayuki Tsuchida
Study on the effects of the hierarchical structures of collagen gels on the morphologies of engineered liver cancer tissues
2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
2016
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Kitagishi H, Minegishi S, Yumura A, Negi S, Taketani S, Amagase Y, Mizukawa Y, Urushidani T, Sugiura Y, Kano K.
Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood
J Am Chem Soc
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Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.
Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.
J Pharm Pharm Sci
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Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T.
In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.
Stem Cell Res Ther
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Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection.
PLoS ONE
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Anan Y, Kimura M, Hayashi M, Koike R, Ogra Y.
Detoxification of selenite to form selenocyanate in mammalian cells.
Chem. Res. Toxicol.
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Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.
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One-step scalable preparation method for non-cationic liposomes with high siRNA content.
Int J Pharm
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Priscilla Boccia, Claudia Meconi, Elena Sturchio, Salvatore Margiotta, Pietro Ragone, Vito Summa
Natural geochemical risk in the Pollino Massif: a case-study of chromium.
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Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.
Natural Product Sciences
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Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
Mutagenicity of Modelled-Heat-Treated Meat Extracts: Mutagenicity Assay, Analysis and Mechanism of Mutagenesis
Jpn J Vet Res
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Kazuya Furusawa, Masayuki Tsuchida, Saki Yahata
Construction of engineered liver cancer tissues with multichannel collagen gel
2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
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Kawase A, Hata S, Takagi M, Iwaki M.
Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption
J Pharm Pharm Sci
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Mira A, Shimizu K.
In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and its Isolated Compounds
Pharmacogn Mag
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Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers
Proc Natl Acad Sci U S A
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Ohtera A, Miyamae Y, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M.
Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy
ACS Chem Biol
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Hara-Yamamura H, Nakashima K, Hoque A, Miyoshi T, Kimura K, Watanabe Y, Okabe S.
Evaluation of whole wastewater effluent impacts on HepG2 using DNA microarray-based transcriptome analysis
Environ Sci Technol
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Uemura T, Tanaka Y, Higashi K, Miyamori D, Takasaka T, Nagano T, Toida T, Yoshimoto K, Igarashi K, Ikegaya H.
Acetaldehyde-induced cytotoxicity involves induction of spermine oxidase at the transcriptional level
Toxicology
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Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
Biol Pharm Bull
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All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells
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