CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1886 : Hep G2]

11987 Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles Hep G2 is a hepatoblastoma-derived cell line Hum Pathol 2009 40(10):1512-5 PubMed ID: 19751877 DOI: 10.1016/j.humpath.2009.07.003

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21073 Matsuo K, Abiko Y, Yamano S, Toriba A, Matsusue K, Kumagai Y. Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine. Biol Pharm Bull 2023 46(2):338-342 PubMed ID: 36724962 DOI: 10.1248/bpb.b22-00543

21074 Matsuo K, Abiko Y, Yamano S, Matsusue K, Kumagai Y. Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine. Biol Pharm Bull 2023 46(2):334-337 PubMed ID: 36724961 DOI: 10.1248/bpb.b22-00531

20483 Koide R, Hirane N, Kambe D, Yokoi Y, Otaki M, Nishimura SI. Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis. Biomaterials 2022 280:121314 PubMed ID: 34906850 DOI: 10.1016/j.biomaterials.2021.121314

16114 Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK. Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts Cell Biol Toxicol 2022 Mar 15 PubMed ID: 33723743 DOI: 10.1007/s10565-021-09592-2

16273 Sakai S, Kotani T, Harada R, Goto R, Morita T, Bouissil S, Dubessay P, Pierre G, Michaud P, El Boutachfaiti R, Nakahata M, Kojima M, Petit E, Delattre C. Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks Carbohydr Polym 2022 277:118820 PubMed ID: 34893237 DOI: 10.1016/j.carbpol.2021.118820

20613 Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M. Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells. Analyst 2022 PubMed ID: 35297918 DOI: 10.1039/d2an00052k

20752 Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K. Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells. J Toxicol Sci 2022 47(6):249-255 PubMed ID: 35650141 DOI: 10.2131/jts.47.249

20753 Luong NC, Abiko Y, Aoki H, Kumagai Y. A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones. Biol Pharm Bull 2022 45(6):798-802 PubMed ID: 35650106 DOI: 10.1248/bpb.b22-00080

16739 Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T. Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles J Biotechnol 2022 354:34-44 PubMed ID: 35724765 DOI: 10.1016/j.jbiotec.2022.06.006

20784 Abiko Y, Taguchi K, Hisamori M, Hiyoshi-Arai K, Luong NC, Toriba A, Kumagai Y. Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor. Chem Res Toxicol 2022 PubMed ID: 35862866 DOI: 10.1021/acs.chemrestox.2c00174

16971 Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M. Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells Int J Mol Sci 2022 23(15):8660 PubMed ID: 35955793 DOI: 10.3390/ijms23158660

20862 Tachikawa R, Saito H, Moteki H, Kimura M, Kitagishi H, Arce F Jr, See GL, Tanikawa T, Inoue Y. Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins. ACS Omega 2022 7(35):31233-31245 PubMed ID: 36092555 DOI: 10.1021/acsomega.2c03489

20947 Ishida-Ishihara S, Takada R, Furusawa K, Ishihara S, Haga H. Improvement of the cell viability of hepatocytes cultured in three-dimensional collagen gels using pump-free perfusion driven by water level difference. Sci Rep 2022 12(1):20269 PubMed ID: 36434099 DOI: 10.1038/s41598-022-24423-y

17333 Inaba H, Sueki Y, Ichikawa M, Kabir AMR, Iwasaki T, Shigematsu H, Kakugo A, Sada K, Tsukazaki T, Matsuura K. Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside Sci Adv 2022 8(36):eabq3817 PubMed ID: 36070375 DOI: 10.1126/sciadv.abq3817

20997 Kawaguchi M, Noda M, Ono A, Kamiya M, Matsumoto M, Tsurumaru M, Mizukami S, Mukai H, Kawakami S. Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice. J Pharm Sci 2022 PubMed ID: 36596392 DOI: 10.1016/j.xphs.2022.12.026

21019 Kazama R, Fujita S, Sakai S. Cell Dome as an Evaluation Platform for Organized HepG2 Cells. Cells 2022 PubMed ID: 36611862 DOI: 10.3390/cells12010069

13179 Hayakawa EH, Kato H, Nardone GA, Usukura J. A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells. Parasitol Int 2021 PubMed ID: 32853776 DOI: 10.1016/j.parint.2020.102179

13396 Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M. Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis. Biochem Biophys Rep 2021 PubMed ID: 33392396 DOI: 10.1016/j.bbrep.2020.100882

13418 Abiko Y, Aoki H, Kumagai Y. Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome. Toxicol Appl Pharmacol 2021 PubMed ID: 33428920 DOI: 10.1016/j.taap.2020.115392

20024 Yamazaki T, Tokiwa T. Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions. Hum Cell 2021 PubMed ID: 33495943 DOI: 10.1007/s13577-021-00487-2

20049 Abiko Y, Katayama Y, Akiyama M, Kumagai Y. Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts. Food Chem Toxicol 2021 150:112061 PubMed ID: 33587975 DOI: 10.1016/j.fct.2021.112061

20081 Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M. The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma. Oncotarget 2021 12(4):333-343 PubMed ID: 33659044 DOI: 10.18632/oncotarget.27881

20119 Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H. Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication. Commun Biol 2021 4(1):425 PubMed ID: 33782534 DOI: 10.1038/s42003-021-01880-1

20166 Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M. CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma. Hepatol Commun 2021 5(2):334-348 PubMed ID: 33553979 DOI: 10.1002/hep4.1643

20204 Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C. Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells. Monoclon Antib Immunodiagn Immunother 2021 40(3):118-123 PubMed ID: 34076498 DOI: 10.1089/mab.2020.0046

20281 Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M. Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten. J Food Sci Technol 2021 58(9):3504-3513 PubMed ID: 34366467 DOI: 10.1007/s13197-021-05040-5

20288 Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y. Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells. Int J Mol Sci 2021 22(6) PubMed ID: 33799598 DOI: 10.3390/ijms22062843

20384 Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T. Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia. Mol Pharm 2021 PubMed ID: 34734526 DOI: 10.1021/acs.molpharmaceut.1c00490

20502 Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K. PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α. Cells 2021 10(12) PubMed ID: 34944058 DOI: 10.3390/cells10123550

16100 Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Yamamoto Y, Morimura R, Ikoma H, Okamoto K, Kamiya M, Urano Y, Otsuji E. Rapid fluorescence imaging of human hepatocellular carcinoma using the β-galactosidase-activatable fluorescence probe SPiDER-βGal Sci Rep 2021 11(1):1794 PubMed ID: 34504174 DOI: 10.1038/s41598-021-97073-1

16205 Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H. Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway J Nutr Biochem 2021 89:108573 PubMed ID: 33388347 DOI: 10.1016/j.jnutbio.2020.108573

16370 Enokiya T, Nishikawa K, Hamada Y, Ikemura K, Sugimura Y, Okuda M. Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene Basic Clin Pharmacol Toxicol 2021 128(3):525-533 PubMed ID: 33248001 DOI: 10.1111/bcpt.13539

16372 Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment Journal of Crystal Growth 2021 572:126265 DOI: 10.1016/j.jcrysgro.2021.126265

20621 Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A. Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats. J Toxicol Sci 2021 46(12):569-587 PubMed ID: 34853243 DOI: 10.2131/jts.46.569

12057 Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K. Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver. Biochim Biophys Acta Mol Basis Dis 2020 PubMed ID: 32088316 DOI: 10.1016/j.bbadis.2020.165731

12094 Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H. Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet. Tissue Eng Part C Methods 2020 PubMed ID: 32186996 DOI: 10.1089/ten.tec.2019.0330

12198 Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells Nature Communications 2020 11:5292 PubMed ID: 33087715 DOI: 10.1038/s41467-020-19041-z

12439 Fujiyama Y, Kumamoto Y, Nishizawa N, Nakamoto S, Harada H, Yokota K, Tanaka Y, Igarashi K, Oiki H, Okuwaki K, Iwai T, Kajita S, Takahashi H, Tajima H, Kaizu T, Sasaki J, Watanabe M, Yamashita K. Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN) Ann Surg Oncol 2020 27(10):4007-4016 PubMed ID: 32144623 DOI: 10.1245/s10434-020-08291-2

12963 Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M. Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation. ACS Omega 2020 PubMed ID: 32905425 DOI: 10.1021/acsomega.0c02385

13027 Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T. Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells. In Vitro Cell Dev Biol Anim 2020 PubMed ID: 32394241 DOI: 10.1007/s11626-020-00451-8

13053 Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ. TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells. Cell Death Dis 2020 PubMed ID: 32471991 DOI: 10.1038/s41419-020-2618-6

13073 Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T. Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling. Free Radic Biol Med 2020 PubMed ID: 32553752 DOI: 10.1016/j.freeradbiomed.2020.06.005

13103 Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J. Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets. NPJ Precis Oncol 2020 PubMed ID: 32656360 DOI: 10.1038/s41698-020-0125-y

13189 Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y. A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract. Food Chem Toxicol 2020 PubMed ID: 32871193 DOI: 10.1016/j.fct.2020.111706

13191 Xu DQ, Yuan XJ, Hirayama M, Toyoda H. Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway. In Vivo 2020 PubMed ID: 32871763 DOI: 10.21873/invivo.12051

13241 Yamashita R, Komaki Y, Yang G, Ibuki Y. Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair. Mutat Res 2020 PubMed ID: 33198939 DOI: 10.1016/j.mrgentox.2020.503273

13290 Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H. Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential. Sci Rep 2020 PubMed ID: 33060804 DOI: 10.1038/s41598-020-74590-z

13528 Ishizawa K, Togami K, Tada H, Chono S. Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers J Pharm Sci 2020 109(12):3608-3616 PubMed ID: 32926888 DOI: 10.1016/j.xphs.2020.08.028

13635 Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K. Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system Xenobiotica 2020 50(6):654-662 PubMed ID: 31631733 DOI: 10.1080/00498254.2019.1683258

14866 Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I. Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver Mol Pharm 2020 17(8):2821-2830 PubMed ID: 32602343 DOI: 10.1021/acs.molpharmaceut.0c00193

5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272 DOI: 10.1016/j.molcel.2019.09.009

11522 Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H. Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells. J. Cell. Physiol. 2019 PubMed ID: 30993729 DOI: 10.1002/jcp.28625

11538 Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H. Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines. Neoplasia 2019 PubMed ID: 31042624 DOI: 10.1016/j.neo.2019.03.007

11857 Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y. Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists. Molecules 2019 PubMed ID: 31137814 DOI: 10.3390/molecules24102019

6837 Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S. Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves. Anticancer Agents Med Chem 2019 19(13):1651-1657 PubMed ID: 31038081 DOI: 10.2174/1871520619666190416101622

9758 Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line Oncol Lett 2019 17(2):2431-2440 PubMed ID: 30719114 DOI: 10.3892/ol.2018.9869

9759 Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells Fundamental Toxicological Sciences 2019 6 :281-286 DOI: 10.2131/fts.6.281

9763 Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells Biochem Biophys Res Commun 2019 509(1):268-274 PubMed ID: 30583860 DOI: 10.1016/j.bbrc.2018.12.118

11906 Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M. Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells. J Pharm Pharm Sci 2019 PubMed ID: 31804920 DOI: 10.18433/jpps30444

11048 Yuta Kurashina, Ryo Sato, Hiroaki Onoe Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly APL Bioeng 2019 3(4):046101 PubMed ID: 31737859 DOI: 10.1063/1.5109966

11057 Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein Sci Rep 2019 9(1):20359 PubMed ID: 31889141 DOI: 10.1038/s41598-019-56900-2

12238 Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy Anal Chem 2019 91(4):2710-2718 PubMed ID: 30664349 DOI: 10.1021/acs.analchem.8b04393

12365 Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K. Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro Drug Metab Pharmacokinet 2019 34(4):272-279 PubMed ID: 31280915 DOI: 10.1016/j.dmpk.2019.04.005

12443 Kojima K, Nakamura T, Ooizumi Y, Igarashi K, Tanaka T, Yokoi K, Ishii S, Nishizawa N, Katoh H, Kosaka Y, Sato T, Watanabe M, Yamashita K. Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer PLoS One 2019 14(1):e0211108 PubMed ID: 30677088 DOI: 10.1371/journal.pone.0211108

12444 Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T. Plasmodium RON12 localizes to the rhoptry body in sporozoites Parasitol Int 2019 68(1):17-23 PubMed ID: 30290224 DOI: 10.1016/j.parint.2018.10.001

12445 Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T. Glass-based organ-on-a-chip device for restricting small molecular absorption J Biosci Bioeng 2019 127(5):641-646 PubMed ID: 30473393 DOI: 10.1016/j.jbiosc.2018.10.019

12472 Hara M, Takeba Y, Iiri T, Ohta Y, Ootaki M, Watanabe M, Watanabe D, Koizumi S, Otsubo T, Matsumoto N. Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway Cancer Sci 2019 110(1):235-244 PubMed ID: 30390393 DOI: 10.1111/cas.13861

12517 Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K. Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi) Nat Prod Res 2019 33(2):189-195 PubMed ID: 29457741 DOI: 10.1080/14786419.2018.1440229

10634 Hara J, Tanaka Y, Kaneko H, Itoh Y, Ikegaya H. Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains. Arch. Virol. 2018 163:633-637 PubMed ID: 29198036 DOI: 10.1007/s00705-017-3665-x

10641 Kaji K, Nishimura N, Seki K, Sato S, Saikawa S, Nakanishi K, Furukawa M, Kawaratani H, Kitade M, Moriya K, Namisaki T, Yoshiji H. Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake. Int. J. Cancer 2018 142:1712-1722 PubMed ID: 29205334 DOI: 10.1002/ijc.31193

10660 Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M. β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line. Environ Sci Pollut Res Int 2018 25:6320-6328 PubMed ID: 29247416 DOI: 10.1007/s11356-017-0977-z

10774 Yajima Y, Lee CN, Yamada M, Utoh R, Seki M. Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers. J. Biosci. Bioeng. 2018 126(1):111-118 PubMed ID: 29502942 DOI: 10.1016/j.jbiosc.2018.01.022

10786 He Q, Okajima T, Onoe H, Subagyo A, Sueoka K, Kuribayashi-Shigetomi K. Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures. Sci Rep 2018 8:4556 PubMed ID: 29540810 DOI: 10.1038/s41598-018-22598-x

10847 Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K. Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer. PLoS ONE 2018 13:e0194785 PubMed ID: 29746493 DOI: 10.1371/journal.pone.0194785

11025 Isolation of activating factors of serotonin N-acetyltransferase from rice peptides Journal of Functional Foods 2018 41, 148-154 DOI: 10.1016/j.jff.2017.12.051

11089 Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S. Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides. PLoS ONE 2018 13(6):e0198264 PubMed ID: 29856876 DOI: 10.1371/journal.pone.0198264

11139 Saikawa S, Kaji K, Nishimura N, Seki K, Sato S, Nakanishi K, Kitagawa K, Kawaratani H, Kitade M, Moriya K, Namisaki T, Mitoro A, Yoshiji H. Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein. Cancer Lett. 2018 434:120-129 PubMed ID: 30031758 DOI: 10.1016/j.canlet.2018.07.021

11113 Kawai T, Ota N, Imasato A, Shirasaki Y, Otsuka K, Tanaka Y. Profiling of N-linked glycans from 100 cells by capillary electrophoresis with large-volume dual preconcentration by isotachophoresis and stacking. J Chromatogr A 2018 1565:138-144 PubMed ID: 29945790 DOI: 10.1016/j.chroma.2018.06.034

11160 Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O. In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana. J Evid Based Integr Med 2018 PubMed ID: 30088418 DOI: 10.1177/2515690X18790723

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10470 Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J. Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition. Sci Rep 2017 7:8253 PubMed ID: 28811612 DOI: 10.1038/s41598-017-08899-7

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10488 Oda Y, Hidaka M, Suzuki A. Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells. Biol. Pharm. Bull. 2017 40:2005-2009 PubMed ID: 28855448 DOI: 10.1248/bpb.b17-00457

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10519 Zhou Y, Fukuda T, Hang Q, Hou S, Isaji T, Kameyama A, Gu J. Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation. Sci Rep 2017 7:11563 PubMed ID: 28912543 DOI: 10.1038/s41598-017-11911-9

10531 Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, Yamana Y, Fujita K, Sakamoto T, Nomura T, Yoneyama H, Kobara H, Mori H, Iwama H, Okano K, Suzuki Y, Masaki T. Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest. Oncol. Rep. 2017 38:2825-2835 PubMed ID: 29048654 DOI: 10.3892/or.2017.5977

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10936 Cell Sheet Fabrication Using RGD Peptide-Coupled Alginate Hydrogels Fabricated by an Electrodeposition Method Chem. Lett. 2017 46, 605–608 DOI: 10.1246/cl.170003

10959 Induction of Drug Resistance in Human Hepatoma Cells Cultured on a Silicate Fiber-Based 3D Scaffold Adv Biochem Biotechnol 2017 112

10975 Collagen Microparticle-mediated 3D Cell Organization: A Facile Route to Bottom-Up Engineering of Thick and Porous Tissues ACS Biomater. Sci. Eng. 2017 3, 2144–2154 PubMed ID: 33440563 DOI: 10.1021/acsbiomaterials.7b00131

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9497 Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita A New Sarasinoside Congener, Sarasinoside M 2, From a Marine Sponge Collected in the Solomon Islands Biosci Biotechnol Biochem 2017 81(2):222-225 PubMed ID: 27760495 DOI: 10.1080/09168451.2016.1246172

10028 Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells Int J Oncol 2017 50(3):787-797. PubMed ID: 28197625 DOI: 10.3892/ijo.2017.3859

12319 Yoshihiko Kihara, Riho Maeda, Azusa Imaizumi, Tsukasa Ichikawa, Nobukatsu Nemoto, Tsutomu Ishihara, Nobutaka Hirano, and Mitsuru Haruki Alkyne-Functionalized Cationic Polysiloxane Polymers Conjugated with Targeting Molecules by Click Reactions for DNA Delivery Journal of Nanoscience and Nanotechnology 2017 17/7:5081-5089 DOI: 10.1166/jnn.2017.13121

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14234 Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E. Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5 Int J Oncol 2017 50(5):1857-1867 PubMed ID: 28358429 DOI: 10.3892/ijo.2017.3940

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9642 Darwish AG, Samy MN, Sugimoto S, Otsuka H, Abdel-Salam H, Matsunami K. Effects of Hepatoprotective Compounds from the Leaves of Lumnitzera racemosa on Acetaminophen-Induced Liver Damage in Vitro. Chem. Pharm. Bull. 2016 64:360-5 PubMed ID: 27039833 DOI: 10.1248/cpb.c15-00830

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9812 Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K. Molecular hydrogen suppresses activated Wnt/β-catenin signaling. Sci Rep 2016 6:31986 PubMed ID: 27558955 DOI: 10.1038/srep31986

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9990 Tanaka Y, Tateishi K, Nakatsuka T, Kudo Y, Takahashi R, Miyabayashi K, Yamamoto K, Asaoka Y, Ijichi H, Tateishi R, Shibahara J, Fukayama M, Ishizawa T, Hasegawa K, Kokudo N, Koike K. Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression. Oncogenesis 2016 5:e277 PubMed ID: 27941932 DOI: 10.1038/oncsis.2016.76

10930 Bioactive Compounds from the Leaves of Lumnitzera racemosa against Acetaminophen-induced Liver damage in vitro Journal of Arid Land Studies 2016 26, 179 - 182 DOI: 10.14976/jals.26.3_183

6039 Badr H, Kozai D, Sakaguchi R, Numata T, Mori Y. Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line. Front Pharmacol 2016 7:19 PubMed ID: 26903865 DOI: 10.3389/fphar.2016.00019

12288 Kung-Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying-Chu Lin, Ming-Ho Tsai, Kenly Wuputra, Yen-Liang Lee, Chia-Chen Ku, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Chun-Chieh Wu, Chee-Yin Chai, Richard Eckner, Chen-Lung Steve Lin, Sophie S-W Wang, Deng-Chyang Wu, Chang-Shen Lin, Kazunari K Yokoyama Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer Stem Cells 2016 34(11):2613-2624 PubMed ID: 27341307 DOI: 10.1002/stem.2447

12644 Minatani N, Waraya M, Yamashita K, Kikuchi M, Ushiku H, Kojo K, Ema A, Nishimiya H, Kosaka Y, Katoh H, Sengoku N, Tanino H, Sidransky D, Watanabe M. Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer PLoS One 2016 11(1):e0144862 PubMed ID: 26785325 DOI: 10.1371/journal.pone.0144862

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13986 Liu Y, Sakai S, Taya M. Engineering tissues with a perfusable vessel-like network using endothelialized alginate hydrogel fiber and spheroid-enclosing microcapsules Heliyon 2016 2(2):e00067 PubMed ID: 27441246 DOI: 10.1016/j.heliyon.2016.e00067

14088 Yoshitaka Koseki, Yoshikazu Ikuta, Takaaki Kamishima, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of Nano-Prodrug Bulletin of the Chemical Society of Japan 2016 89:540–545 DOI: 10.1246/bcsj.20150405

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14152 Kazuya Furusawa, Masayuki Tsuchida Study on the effects of the hierarchical structures of collagen gels on the morphologies of engineered liver cancer tissues 2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS) 2016 DOI: 10.1109/mhs.2016.7824174

14165 Kitagishi H, Minegishi S, Yumura A, Negi S, Taketani S, Amagase Y, Mizukawa Y, Urushidani T, Sugiura Y, Kano K. Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood J Am Chem Soc 2016 138(16):5417-25 PubMed ID: 27057920 DOI: 10.1021/jacs.6b02211

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7219 Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T. In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice. Stem Cell Res Ther 2015 6:171 PubMed ID: 26358689 DOI: 10.1186/s13287-015-0154-6

7238 Ozeki M, Salah A, Aini W, Tamaki K, Haga H, Miyagawa-Hayashino A. Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection. PLoS ONE 2015 10:e0136381 PubMed ID: 26305096 DOI: 10.1371/journal.pone.0136381

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10187 Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka Mutagenicity of Modelled-Heat-Treated Meat Extracts: Mutagenicity Assay, Analysis and Mechanism of Mutagenesis Jpn J Vet Res 2015 63(4):173-82 PubMed ID: 26753243

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15144 Kawase A, Hata S, Takagi M, Iwaki M. Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption J Pharm Pharm Sci 2015 18(5):765-7 PubMed ID: 26670369 DOI: 10.18433/j3m029

15145 Mira A, Shimizu K. In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and its Isolated Compounds Pharmacogn Mag 2015 11(Suppl 4):S564-9 PubMed ID: 27013795 DOI: 10.4103/0973-1296.172962

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