CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1886 : Hep G2]

11987 Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles Hep G2 is a hepatoblastoma-derived cell line Hum Pathol 2009 40(10):1512-5 PubMed ID: 19751877 DOI: 10.1016/j.humpath.2009.07.003

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22405 Sato N, Kusano T, Nagata K, Okamoto K. A non-purine inhibitor of xanthine oxidoreductase mitigates adenosine triphosphate degradation under hypoxic conditions in mouse brain. Brain Res 2025 149444 PubMed ID: 39755194 DOI: 10.1016/j.brainres.2025.149444

22722 Hori A, Hirata M, Nonogaki R, Utoh R, Yamada M. Designing Porosity-Tailored Hydrogel Sponges with Controlled Cell Positioning Using Dispersible, Autofragmented Sacrificial Microfibers. ACS Omega 2025 10(12):11900-11910 PubMed ID: 40191313 DOI: 10.1021/acsomega.4c08536

19845 Uchida Y, Ferdousi F, Takahashi S, Isoda H. Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells Molecules 2024 29(5):1090 PubMed ID: 38474603 DOI: 10.3390/molecules29051090

19882 Kaito S, Takeshita JI, Iwata M, Sasaki T, Hosaka T, Shizu R, Yoshinari K. Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury Xenobiotica 2024 1-30 PubMed ID: 38315106 DOI: 10.1080/00498254.2024.2312505

19985 Shimura M, Higashi-Kuwata N, Fujiwara A, Taniguchi M, Ichinose T, Hamano F, Uematsu M, Inoue T, Matsuyama S, Suzuki T, Ghosh AK, Shindou H, Shimuzu T, Mitsuya H. A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs Antiviral Res 2024 3:223:105819 PubMed ID: 38272319 DOI: 10.1016/j.antiviral.2024.105819

21713 Furuno K, Suzuki K, Sakai S. Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics. Biomolecules 2024 14(4) PubMed ID: 38672522 DOI: 10.3390/biom14040506

21943 Yanagisawa H, Maeda H, Noguchi I, Tanaka M, Wada N, Nagasaki T, Kobayashi K, Kanazawa G, Taguchi K, Chuang VTG, Sakai H, Nakashima H, Kinoshita M, Kitagishi H, Iwakiri Y, Sasaki Y, Tanaka Y, Otagiri M, Watanabe H, Maruyama T. Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation. Redox Biol 2024 76:103314 PubMed ID: 39163766 DOI: 10.1016/j.redox.2024.103314

21944 Ogiwara N, Nakano T, Baba K, Noguchi H, Masuda T, Takai M. High-Quality Three-Dimensionally Cultured Cells Using Interfaces of Diblock Copolymers Containing Different Ratios of Zwitterionic N-Oxides. ACS Appl Mater Interfaces 2024 PubMed ID: 39160767 DOI: 10.1021/acsami.4c10118

21949 Sato T, Shizu R, Baba R, Ooka A, Hosaka T, Kanno Y, Yoshinari K. Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression. Biochem J 2024 PubMed ID: 39171361 DOI: 10.1042/BCJ20240172

21972 Ogawa T, Terada T. The Beneficial Effect of Brazilian Propolis for Liver Damage through Endoplasmic Reticulum Stress Biol Pharm Bull 2024 47(7):1265-1274 PubMed ID: 38987175 DOI: 10.1248/bpb.b24-00092

21991 Kasano-Camones CI, Yokota S, Ohashi M, Sakamoto N, Ito D, Saito Y, Uchida R, Ninomiya K, Inoue Y. Hepatocyte nuclear factor 4α is a critical factor for the production of complement components in the liver. In Vitro Cell Dev Biol Anim 2024 PubMed ID: 39285151 DOI: 10.1007/s11626-024-00972-6

21992 Mitsutani M, Yokoyama M, Hano H, Morita A, Matsushita M, Tagami T, Moriyama K. Growth hormone is involved in GATA1 gene expression via STAT5B in human erythroleukemia and monocytic cell lines. Blood Cells Mol Dis 2024 110:102894 PubMed ID: 39303396 DOI: 10.1016/j.bcmd.2024.102894

22012 Adachi M, Kumagai T, Hosho K, Nagata K, Fujiyoshi M, Shimada M. Exploring Acute Liver Damage: Slimming Health Foods and CYP3A4 Induction. Yonago Acta Med 2024 67(2):124-134 PubMed ID: 38803590 DOI: 10.33160/yam.2024.05.004

22023 Okami K, Fumoto S, Yamashita M, Nakashima M, Miyamoto H, Kawakami S, Nishida K. One-Step Formation Method of Plasmid DNA-Loaded, Extracellular Vesicles-Mimicking Lipid Nanoparticles Based on Nucleic Acids Dilution-Induced Assembly. Cells 2024 13(14): PubMed ID: 39056764 DOI: 10.3390/cells13141183

22363 Yamazaki T, Tokiwa T. Suppressive effect of isofraxidin on the overexpression of IL-6 and its molecular mechanism in a TPA-treated human hepatocellular carcinoma cell line, HuH-7 Naunyn Schmiedebergs Arch Pharmacol 2024 2024 Aug 22 PubMed ID: 39172147 DOI: 10.1007/s00210-024-03394-z

22384 George Adjei-Hinneh, Felix Kwame Zoiku, Evelyn Asante-Kwatia, Abraham Yeboah Mensah In vitro and in vivo evaluation of the antimalarial, anti-inflammatory and free radical scavenging potentials of the hydro-alcoholic leaf extract of Microdesmis puberula Hook. F. ex Planch (Pandaceae) Vegetos 2024 DOI: 10.1007/s42535-024-01056-2

22525 Yoshitaka Koseki, Keita Tanita, Motofumi Nakamura, Aki Shibata, Kiyotaka Maruoka, Takaaki Kamishima, Hitoshi Kasai Fabrication of carrier-free heterodimeric nano-prodrugs with podophyllotoxin and SN-38 for a co-delivery system Molecular Crystals and Liquid Crystals 2024 768:481-487 DOI: 10.1080/15421406.2024.2353966

22643 Shizu R, Makida N, Sobe K, Ishimura M, Takeshita A, Hosaka T, Kanno Y, Sasaki T, Yoshinari K. Interaction with YAP underlies the species differences between humans and rodents in CAR-dependent hepatocyte proliferation Toxicol Sci 2024 198(1):101-112. PubMed ID: 38128062 DOI: 10.1093/toxsci/kfad129

22653 Raghda Shahin, Yoko Sakai, Kotaro Shirai, Tadahiro Hashita, Tamihide Matsunaga, Takahiro Iwao Converting suspension-type human primary hepatocytes to be plateable-type for use as an in vitro pharmacokinetics model Drug Metabolism and Pharmacokinetics 2024 101044 DOI: 10.1016/j.dmpk.2024.101044

19583 Tabei Y, Abe H, Suzuki S, Takeda N, Arai JI, Nakajima Y. Sedanolide Activates KEAP1-NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death Int J Mol Sci 2023 24(22):16532 PubMed ID: 38003720 DOI: 10.3390/ijms242216532

19652 oko Takeo, Kai Sakurai, Noboru Furuya, Kyota Yoshinaga, Takenori Shimamura, Satoru Egawa, Hisao Kiuchi, Hidekazu Mimura, Haruhiko Ohashi, Yoshihisa Harada, Mari Shimura, Takashi Kimura Development of soft X-ray ptychography and fluorescence microscopy system using total-reflection wolter mirror and application to measurement of drug-treated mammalian cells Journal of Electron Spectroscopy and Related Phenomena 2023 237:147380 DOI: 10.1016/j.elspec.2023.147380

19659 Goto R, Nakahata M, Delattre C, Petit E, El Boutachfaiti R, Sakai S. Fabrication of cell-laden microbeads and microcapsules composed of bacterial polyglucuronic acid Int J Biol Macromol 2023 244:125481 PubMed ID: 37343612 DOI: 10.1016/j.ijbiomac.2023.125481

19663 Kotani T, Mubarok W, Hananouchi T, Sakai S. Horseradish Peroxidase-Mediated Bioprinting via Bioink Gelation by Alternately Extruded Support Material ACS Biomater Sci Eng 2023 9(10):5804-5812 PubMed ID: 37738620 DOI: 10.1021/acsbiomaterials.3c00996

19800 Hori M, Takahashi A, Hosoda K, Ogura M, Harada-Shiba M. A Low-Frequency APOB p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia J Clin Endocrinol Metab 2023 108(2):422-432 PubMed ID: 36190978 DOI: 10.1210/clinem/dgac572

19810 Sekiguchi M, Fujinami Y, Takado K, Kimoto Y, Higashimura Y. Activity difference of three labdane diterpenoids on human constitutive androstane receptor Biosci Biotechnol Biochem 2023 87(11):1310-1315 PubMed ID: 37580155 DOI: 10.1093/bbb/zbad113

19821 Liu S, Morihiro K, Takeuchi F, Li Y, Okamoto A. Interstrand crosslinking oligonucleotides elucidate the effect of metal ions on the methylation status of repetitive DNA elements Front Chem 2023 11:1122474 PubMed ID: 36711237 DOI: 10.3389/fchem.2023.1122474

19846 Takagi M, Yamada M, Utoh R, Seki M. A multiscale, vertical-flow perfusion system with integrated porous microchambers for upgrading multicellular spheroid culture Lab Chip 2023 23(9):2257-2267 PubMed ID: 37038847 DOI: 10.1039/d3lc00168g

19919 Wuputra K, Tsai MH, Kato K, Ku CC, Pan JB, Yang YH, Saito S, Wu CC, Lin YC, Cheng KH, Kuo KK, Noguchi M, Nakamura Y, Yoshioka T, Wu DC, Lin CS, Yokoyama KK. Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery Inflamm Regen 2023 43(1):42 PubMed ID: 37596694 DOI: 10.1186/s41232-023-00290-6

19948 Ota K, Sakai S, Ohhata T, Suzuki T, Uchida C, Niida H, Kitagawa M. APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway Carcinogenesis 2023 44(1):1-14 PubMed ID: 36335471 DOI: 10.1093/carcin/bgac086

19960 Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H. An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types BMC Genomics 2023 24(1):735 PubMed ID: 38049715 DOI: 10.1186/s12864-023-09841-0

21073 Matsuo K, Abiko Y, Yamano S, Toriba A, Matsusue K, Kumagai Y. Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine. Biol Pharm Bull 2023 46(2):338-342 PubMed ID: 36724962 DOI: 10.1248/bpb.b22-00543

21074 Matsuo K, Abiko Y, Yamano S, Matsusue K, Kumagai Y. Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine. Biol Pharm Bull 2023 46(2):334-337 PubMed ID: 36724961 DOI: 10.1248/bpb.b22-00531

21276 Mubarok W, Elvitigala KCML, Kotani T, Sakai S. Visible light photocrosslinking of sugar beet pectin for 3D bioprinting applications. Carbohydr Polym 2023 316:121026 PubMed ID: 37321724 DOI: 10.1016/j.carbpol.2023.121026

17493 Yamazaki K, Matsuo K, Okada A, Uno N, Suzuki T, Abe S, Hamamichi S, Kishima N, Togai S, Tomizuka K, Kazuki Y. Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery Sci Rep 2022 12(1):21790 PubMed ID: 36526651 DOI: 10.1038/s41598-022-25959-9

17512 amamoto H, Yoshida N, Kihara S. Esaxerenone Blocks Vascular Endothelial Inflammation Through SGK1 J Cardiovasc Pharmacol 2022 80(4):583-591 PubMed ID: 35900901 DOI: 10.1097/FJC.0000000000001316

17594 Akiyama M, Shinkai Y, Yamakawa H, Kim YG, Kumagai Y. Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome Chemosphere 2022 299:134374 PubMed ID: 35318019 DOI: 10.1016/j.chemosphere.2022.134374

17669 Kamiya M, Matsumoto M, Yamashita K, Izumi T, Kawaguchi M, Mizukami S, Tsurumaru M, Mukai H, Kawakami S. Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability Pharmaceutics 2022 14(11):2357 PubMed ID: 36365175 DOI: 10.3390/pharmaceutics14112357

17788 Takeuchi Y, Ushimaru K, Kaneda K, Maruyama C, Ito T, Yamanaka K, Ogasawara Y, Katano H, Kato Y, Dairi T, Hamano Y. First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria Commun Biol 2022 5(1):1132 PubMed ID: 36289442 DOI: 10.1038/s42003-022-04110-4

19530 Hu D, Fumoto S, Miyamoto H, Tanaka M, Nishida K. Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation Pharmaceutics 2022 14(6):1203 PubMed ID: 35745776 DOI: 10.3390/pharmaceutics14061203

20483 Koide R, Hirane N, Kambe D, Yokoi Y, Otaki M, Nishimura SI. Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis. Biomaterials 2022 280:121314 PubMed ID: 34906850 DOI: 10.1016/j.biomaterials.2021.121314

16114 Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK. Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts Cell Biol Toxicol 2022 Mar 15 PubMed ID: 33723743 DOI: 10.1007/s10565-021-09592-2

16273 Sakai S, Kotani T, Harada R, Goto R, Morita T, Bouissil S, Dubessay P, Pierre G, Michaud P, El Boutachfaiti R, Nakahata M, Kojima M, Petit E, Delattre C. Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks Carbohydr Polym 2022 277:118820 PubMed ID: 34893237 DOI: 10.1016/j.carbpol.2021.118820

20613 Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M. Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells. Analyst 2022 PubMed ID: 35297918 DOI: 10.1039/d2an00052k

20657 Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y. Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure. Biochem Biophys Rep 2022 29:101223 PubMed ID: 35146136 DOI: 10.1016/j.bbrep.2022.101223

20752 Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K. Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells. J Toxicol Sci 2022 47(6):249-255 PubMed ID: 35650141 DOI: 10.2131/jts.47.249

20753 Luong NC, Abiko Y, Aoki H, Kumagai Y. A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones. Biol Pharm Bull 2022 45(6):798-802 PubMed ID: 35650106 DOI: 10.1248/bpb.b22-00080

16739 Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T. Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles J Biotechnol 2022 354:34-44 PubMed ID: 35724765 DOI: 10.1016/j.jbiotec.2022.06.006

20784 Abiko Y, Taguchi K, Hisamori M, Hiyoshi-Arai K, Luong NC, Toriba A, Kumagai Y. Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor. Chem Res Toxicol 2022 PubMed ID: 35862866 DOI: 10.1021/acs.chemrestox.2c00174

16971 Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M. Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells Int J Mol Sci 2022 23(15):8660 PubMed ID: 35955793 DOI: 10.3390/ijms23158660

20862 Tachikawa R, Saito H, Moteki H, Kimura M, Kitagishi H, Arce F Jr, See GL, Tanikawa T, Inoue Y. Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins. ACS Omega 2022 7(35):31233-31245 PubMed ID: 36092555 DOI: 10.1021/acsomega.2c03489

20947 Ishida-Ishihara S, Takada R, Furusawa K, Ishihara S, Haga H. Improvement of the cell viability of hepatocytes cultured in three-dimensional collagen gels using pump-free perfusion driven by water level difference. Sci Rep 2022 12(1):20269 PubMed ID: 36434099 DOI: 10.1038/s41598-022-24423-y

17333 Inaba H, Sueki Y, Ichikawa M, Kabir AMR, Iwasaki T, Shigematsu H, Kakugo A, Sada K, Tsukazaki T, Matsuura K. Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside Sci Adv 2022 8(36):eabq3817 PubMed ID: 36070375 DOI: 10.1126/sciadv.abq3817

20997 Kawaguchi M, Noda M, Ono A, Kamiya M, Matsumoto M, Tsurumaru M, Mizukami S, Mukai H, Kawakami S. Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice. J Pharm Sci 2022 PubMed ID: 36596392 DOI: 10.1016/j.xphs.2022.12.026

21019 Kazama R, Fujita S, Sakai S. Cell Dome as an Evaluation Platform for Organized HepG2 Cells. Cells 2022 PubMed ID: 36611862 DOI: 10.3390/cells12010069

21983 Hu X, Roy SR, Jin C, Li G, Zhang Q, Asano N, Asahina S, Kajiwara T, Takahara A, Feng B, Aoki K, Xu C, Zhang Y. Control cell migration by engineering integrin ligand assembly. Nat Commun 2022 13(1):5002 PubMed ID: 36008449 DOI: 10.1038/s41467-022-32686-2

22635 Okamoto Y, Kishikawa N, Hagimori M, El-Maghrabey M, Kawakami S, Kuroda N. A turn-on hydrazide oxidative decomposition-based fluorescence probe for highly selective detection of Cu2+ in tap water as well as cell imaging Anal Chim Acta 2022 1217:340024 PubMed ID: 35690425 DOI: 10.1016/j.aca.2022.340024

13179 Hayakawa EH, Kato H, Nardone GA, Usukura J. A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells. Parasitol Int 2021 PubMed ID: 32853776 DOI: 10.1016/j.parint.2020.102179

13396 Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M. Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis. Biochem Biophys Rep 2021 PubMed ID: 33392396 DOI: 10.1016/j.bbrep.2020.100882

13418 Abiko Y, Aoki H, Kumagai Y. Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome. Toxicol Appl Pharmacol 2021 PubMed ID: 33428920 DOI: 10.1016/j.taap.2020.115392

20024 Yamazaki T, Tokiwa T. Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions. Hum Cell 2021 PubMed ID: 33495943 DOI: 10.1007/s13577-021-00487-2

20049 Abiko Y, Katayama Y, Akiyama M, Kumagai Y. Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts. Food Chem Toxicol 2021 150:112061 PubMed ID: 33587975 DOI: 10.1016/j.fct.2021.112061

20081 Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M. The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma. Oncotarget 2021 12(4):333-343 PubMed ID: 33659044 DOI: 10.18632/oncotarget.27881

20119 Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H. Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication. Commun Biol 2021 4(1):425 PubMed ID: 33782534 DOI: 10.1038/s42003-021-01880-1

20166 Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M. CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma. Hepatol Commun 2021 5(2):334-348 PubMed ID: 33553979 DOI: 10.1002/hep4.1643

20204 Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C. Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells. Monoclon Antib Immunodiagn Immunother 2021 40(3):118-123 PubMed ID: 34076498 DOI: 10.1089/mab.2020.0046

20281 Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M. Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten. J Food Sci Technol 2021 58(9):3504-3513 PubMed ID: 34366467 DOI: 10.1007/s13197-021-05040-5

20288 Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y. Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells. Int J Mol Sci 2021 22(6) PubMed ID: 33799598 DOI: 10.3390/ijms22062843

20384 Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T. Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia. Mol Pharm 2021 PubMed ID: 34734526 DOI: 10.1021/acs.molpharmaceut.1c00490

20502 Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K. PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α. Cells 2021 10(12) PubMed ID: 34944058 DOI: 10.3390/cells10123550

16100 Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Yamamoto Y, Morimura R, Ikoma H, Okamoto K, Kamiya M, Urano Y, Otsuji E. Rapid fluorescence imaging of human hepatocellular carcinoma using the β-galactosidase-activatable fluorescence probe SPiDER-βGal Sci Rep 2021 11(1):1794 PubMed ID: 34504174 DOI: 10.1038/s41598-021-97073-1

16205 Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H. Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway J Nutr Biochem 2021 89:108573 PubMed ID: 33388347 DOI: 10.1016/j.jnutbio.2020.108573

16370 Enokiya T, Nishikawa K, Hamada Y, Ikemura K, Sugimura Y, Okuda M. Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene Basic Clin Pharmacol Toxicol 2021 128(3):525-533 PubMed ID: 33248001 DOI: 10.1111/bcpt.13539

16372 Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment Journal of Crystal Growth 2021 572:126265 DOI: 10.1016/j.jcrysgro.2021.126265

20621 Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A. Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats. J Toxicol Sci 2021 46(12):569-587 PubMed ID: 34853243 DOI: 10.2131/jts.46.569

22038 Taguchi T, Kodera Y, Oba K, Saito T, Nakagawa Y, Kawashima Y, Shichiri M. Suprabasin-derived bioactive peptides identified by plasma peptidomics. Sci Rep 2021 PubMed ID: 33441610 DOI: 10.1038/s41598-020-79353-4

19253 Wen-Ying Liu, Takuya Miyakawa, Jun Lu, Rui-Zeng Gu, Yun Hua Hsieh, Yumiko Miyauchi, Kana Katsuno, Mu-Yi Cai, Masaru Tanokura Low-molecular-weight peptides with potential cardiovascular regulatory functions from Atlantic salmon skin International Journal of Food Engineering 2020 16 DOI: 10.1515/ijfe-2020-0072

19410 Fukushima T, Jintana W, Okabe S. Mixture toxicity of the combinations of silver nanoparticles and environmental pollutants Environ Sci Pollut Res Int 2020 27(6):6326-6337. PubMed ID: 31865577 DOI: 10.1007/s11356-019-07413-y

12030 Yoshizawa N, Sugimoto K, Tameda M, Inagaki Y, Ikejiri M, Inoue H, Usui M, Ito M, Takei Y. miR-3940-5p/miR-8069 ratio in urine exosomes is a novel diagnostic biomarker for pancreatic ductal adenocarcinoma. Oncol Lett 2020 PubMed ID: 32218818 DOI: 10.3892/ol.2020.11357

12057 Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K. Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver. Biochim Biophys Acta Mol Basis Dis 2020 PubMed ID: 32088316 DOI: 10.1016/j.bbadis.2020.165731

12094 Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H. Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet. Tissue Eng Part C Methods 2020 PubMed ID: 32186996 DOI: 10.1089/ten.tec.2019.0330

12198 Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells Nature Communications 2020 11:5292 PubMed ID: 33087715 DOI: 10.1038/s41467-020-19041-z

12439 Fujiyama Y, Kumamoto Y, Nishizawa N, Nakamoto S, Harada H, Yokota K, Tanaka Y, Igarashi K, Oiki H, Okuwaki K, Iwai T, Kajita S, Takahashi H, Tajima H, Kaizu T, Sasaki J, Watanabe M, Yamashita K. Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN) Ann Surg Oncol 2020 27(10):4007-4016 PubMed ID: 32144623 DOI: 10.1245/s10434-020-08291-2

12963 Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M. Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation. ACS Omega 2020 PubMed ID: 32905425 DOI: 10.1021/acsomega.0c02385

13027 Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T. Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells. In Vitro Cell Dev Biol Anim 2020 PubMed ID: 32394241 DOI: 10.1007/s11626-020-00451-8

13036 Tanaka M, Sato A, Kishimoto Y, Mabashi-Asazuma H, Kondo K, Iida K. Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. Nutrients 2020 PubMed ID: 32443660 DOI: 10.3390/nu12051479

13053 Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ. TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells. Cell Death Dis 2020 PubMed ID: 32471991 DOI: 10.1038/s41419-020-2618-6

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13189 Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y. A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract. Food Chem Toxicol 2020 PubMed ID: 32871193 DOI: 10.1016/j.fct.2020.111706

13191 Xu DQ, Yuan XJ, Hirayama M, Toyoda H. Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway. In Vivo 2020 PubMed ID: 32871763 DOI: 10.21873/invivo.12051

13241 Yamashita R, Komaki Y, Yang G, Ibuki Y. Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair. Mutat Res 2020 PubMed ID: 33198939 DOI: 10.1016/j.mrgentox.2020.503273

13290 Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H. Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential. Sci Rep 2020 PubMed ID: 33060804 DOI: 10.1038/s41598-020-74590-z

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5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272 DOI: 10.1016/j.molcel.2019.09.009

11522 Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H. Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells. J. Cell. Physiol. 2019 PubMed ID: 30993729 DOI: 10.1002/jcp.28625

11538 Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H. Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines. Neoplasia 2019 PubMed ID: 31042624 DOI: 10.1016/j.neo.2019.03.007

11857 Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y. Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists. Molecules 2019 PubMed ID: 31137814 DOI: 10.3390/molecules24102019

6837 Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S. Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves. Anticancer Agents Med Chem 2019 19(13):1651-1657 PubMed ID: 31038081 DOI: 10.2174/1871520619666190416101622

9758 Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line Oncol Lett 2019 17(2):2431-2440 PubMed ID: 30719114 DOI: 10.3892/ol.2018.9869

9759 Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells Fundamental Toxicological Sciences 2019 6 :281-286 DOI: 10.2131/fts.6.281

9763 Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells Biochem Biophys Res Commun 2019 509(1):268-274 PubMed ID: 30583860 DOI: 10.1016/j.bbrc.2018.12.118

11906 Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M. Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells. J Pharm Pharm Sci 2019 PubMed ID: 31804920 DOI: 10.18433/jpps30444

11048 Yuta Kurashina, Ryo Sato, Hiroaki Onoe Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly APL Bioeng 2019 3(4):046101 PubMed ID: 31737859 DOI: 10.1063/1.5109966

11057 Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein Sci Rep 2019 9(1):20359 PubMed ID: 31889141 DOI: 10.1038/s41598-019-56900-2

12238 Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy Anal Chem 2019 91(4):2710-2718 PubMed ID: 30664349 DOI: 10.1021/acs.analchem.8b04393

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12444 Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T. Plasmodium RON12 localizes to the rhoptry body in sporozoites Parasitol Int 2019 68(1):17-23 PubMed ID: 30290224 DOI: 10.1016/j.parint.2018.10.001

12445 Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T. Glass-based organ-on-a-chip device for restricting small molecular absorption J Biosci Bioeng 2019 127(5):641-646 PubMed ID: 30473393 DOI: 10.1016/j.jbiosc.2018.10.019

12472 Hara M, Takeba Y, Iiri T, Ohta Y, Ootaki M, Watanabe M, Watanabe D, Koizumi S, Otsubo T, Matsumoto N. Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway Cancer Sci 2019 110(1):235-244 PubMed ID: 30390393 DOI: 10.1111/cas.13861

12517 Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K. Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi) Nat Prod Res 2019 33(2):189-195 PubMed ID: 29457741 DOI: 10.1080/14786419.2018.1440229

22043 Sarma SN, Nagano R, Ohsako S. Tyroxine Hydroxylase-Positive Neuronal Cell Population is Increased by Temporal Dioxin Exposure at Early Stage of Differentiation from Human Embryonic Stem Cells. Int J Mol Sci 2019 20(11) PubMed ID: 31159217 DOI: 10.3390/ijms20112687

22044 Fujiyoshi J, Yamaza H, Sonoda S, Yuniartha R, Ihara K, Nonaka K, Taguchi T, Ohga S, Yamaza T. Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease. Sci Rep 2019 9(1):1535 PubMed ID: 30733544 DOI: 10.1038/s41598-018-38275-y

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10660 Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M. β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line. Environ Sci Pollut Res Int 2018 25:6320-6328 PubMed ID: 29247416 DOI: 10.1007/s11356-017-0977-z

10774 Yajima Y, Lee CN, Yamada M, Utoh R, Seki M. Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers. J. Biosci. Bioeng. 2018 126(1):111-118 PubMed ID: 29502942 DOI: 10.1016/j.jbiosc.2018.01.022

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11025 Isolation of activating factors of serotonin N-acetyltransferase from rice peptides Journal of Functional Foods 2018 41, 148-154 DOI: 10.1016/j.jff.2017.12.051

11089 Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S. Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides. PLoS ONE 2018 13(6):e0198264 PubMed ID: 29856876 DOI: 10.1371/journal.pone.0198264

11139 Saikawa S, Kaji K, Nishimura N, Seki K, Sato S, Nakanishi K, Kitagawa K, Kawaratani H, Kitade M, Moriya K, Namisaki T, Mitoro A, Yoshiji H. Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein. Cancer Lett. 2018 434:120-129 PubMed ID: 30031758 DOI: 10.1016/j.canlet.2018.07.021

11113 Kawai T, Ota N, Imasato A, Shirasaki Y, Otsuka K, Tanaka Y. Profiling of N-linked glycans from 100 cells by capillary electrophoresis with large-volume dual preconcentration by isotachophoresis and stacking. J Chromatogr A 2018 1565:138-144 PubMed ID: 29945790 DOI: 10.1016/j.chroma.2018.06.034

11160 Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O. In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana. J Evid Based Integr Med 2018 PubMed ID: 30088418 DOI: 10.1177/2515690X18790723

11292 Hori T, Kurosawa O. A Three-dimensional Cell Culture Method with a Micromesh Sheet and Its Application to Hepatic Cells. Tissue Eng Part C Methods 2018 PubMed ID: 30412042 DOI: 10.1089/ten.TEC.2018.0269

4452 Phoebe Trio1, Atsuyoshi Kawahara, Satoru Fujisaki, De-Xing Hou Comparative Gene Expression Profiling in Cultured Cell Lines after Treatment with Wasabi-derived Isothiocyanates KIMIKA 2018 29, 1-10 DOI: 10.26534/kimika.v29i1.1-10

4224 Sultana H, Watanabe K, Rana MM, Takashima R, Ohashi A, Komai M, Shirakawa H. Effects of Vitamin K₂ on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR. Nutrients 2018 PubMed ID: 30060524 DOI: 10.3390/nu10080982

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10167 Takahashi K, Suzuki N, Ogra Y. Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo. Int J Mol Sci 2017 18: PubMed ID: 28245633 DOI: 10.3390/ijms18030506

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10351 Nakashima KI, Ogiwara T, Hirai T, Tanaka T, Murata H, Kaburagi K, Fujii-Kuriyama Y, Hayashi H, Inoue M. Gerontoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist. Bioorg. Med. Chem. 2017 25:4253-4258 PubMed ID: 28662965 DOI: 10.1016/j.bmc.2017.05.047

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10435 Tung NH, Uto T, Hai NT, Li G, Shoyama Y. Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines. Pharmacogn Mag 2017 13:459-462 PubMed ID: 28839372 DOI: 10.4103/pm.pm_353_16

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10466 Machihara K, Tanaka H, Hayashi Y, Murakami I, Namba T. Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78. Biochem. Biophys. Res. Commun. 2017 492:33-40 PubMed ID: 28811106 DOI: 10.1016/j.bbrc.2017.08.042

10470 Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J. Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition. Sci Rep 2017 7:8253 PubMed ID: 28811612 DOI: 10.1038/s41598-017-08899-7

10478 Fukushima T, Hara-Yamamura H, Nakashima K, Tan LC, Okabe S. Multiple-endpoints gene alteration-based (MEGA) assay: A toxicogenomics approach for water quality assessment of wastewater effluents. Chemosphere 2017 188:312-319 PubMed ID: 28888119 DOI: 10.1016/j.chemosphere.2017.08.107

10488 Oda Y, Hidaka M, Suzuki A. Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells. Biol. Pharm. Bull. 2017 40:2005-2009 PubMed ID: 28855448 DOI: 10.1248/bpb.b17-00457

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10531 Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, Yamana Y, Fujita K, Sakamoto T, Nomura T, Yoneyama H, Kobara H, Mori H, Iwama H, Okano K, Suzuki Y, Masaki T. Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest. Oncol. Rep. 2017 38:2825-2835 PubMed ID: 29048654 DOI: 10.3892/or.2017.5977

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10959 Induction of Drug Resistance in Human Hepatoma Cells Cultured on a Silicate Fiber-Based 3D Scaffold Adv Biochem Biotechnol 2017 112

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