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Cell No. : Cell Name
RCB1886 : Hep G2  update : 2022/11/25
CommentHuman cell line derived from hepatoblastoma. Secretes several products such as albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. TKG0205 (Deposited from Tohoku Univ.). Information
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0205 HepG2
Animal human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Male
Age at sampling 15 years
Tissue liver
Disease name hepatocyte carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0205)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0027
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 164


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Reference
11987  Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles  Hep G2 is a hepatoblastoma-derived cell line  Hum Pathol  2009  40(10):1512-5  PubMed ID: 19751877   DOI: 10.1016/j.humpath.2009.07.003
1155  Knowles, B B, Howe, C C, Aden, D P  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.  Science  1980  209:497-9  PubMed ID: 6248960   DOI: 10.1126/science.6248960
4984  Diamond L1, Kruszewski F, Aden DP, Knowles BB, Baird WM.  Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.  Carcinogenesis  1980  1(10):871-5  PubMed ID: 11219860   DOI: 10.1093/carcin/1.10.871
465  Aden, D P, Fogel A, Plotkin S, Damjanov I, Knowles, B B  Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.  Nature  1979  282:615-6  PubMed ID: 233137   DOI: 10.1038/282615a0

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User's Publication
20483  Koide R, Hirane N, Kambe D, Yokoi Y, Otaki M, Nishimura SI.  Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis.  Biomaterials  2022  280:121314  PubMed ID: 34906850   DOI: 10.1016/j.biomaterials.2021.121314
16114  Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK.  Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts  Cell Biol Toxicol  2022  Mar 15  PubMed ID: 33723743   DOI: 10.1007/s10565-021-09592-2
16273  Sakai S, Kotani T, Harada R, Goto R, Morita T, Bouissil S, Dubessay P, Pierre G, Michaud P, El Boutachfaiti R, Nakahata M, Kojima M, Petit E, Delattre C.  Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks  Carbohydr Polym  2022  277:118820  PubMed ID: 34893237   DOI: 10.1016/j.carbpol.2021.118820
20613  Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.  Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.  Analyst  2022    PubMed ID: 35297918   DOI: 10.1039/d2an00052k
20752  Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.  Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.  J Toxicol Sci  2022  47(6):249-255  PubMed ID: 35650141   DOI: 10.2131/jts.47.249
20753  Luong NC, Abiko Y, Aoki H, Kumagai Y.  A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones.  Biol Pharm Bull  2022  45(6):798-802  PubMed ID: 35650106   DOI: 10.1248/bpb.b22-00080
16739  Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T.  Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles  J Biotechnol  2022  354:34-44  PubMed ID: 35724765   DOI: 10.1016/j.jbiotec.2022.06.006
20784  Abiko Y, Taguchi K, Hisamori M, Hiyoshi-Arai K, Luong NC, Toriba A, Kumagai Y.  Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor.  Chem Res Toxicol  2022    PubMed ID: 35862866   DOI: 10.1021/acs.chemrestox.2c00174
16971  Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M.  Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells  Int J Mol Sci  2022  23(15):8660  PubMed ID: 35955793   DOI: 10.3390/ijms23158660
20862  Tachikawa R, Saito H, Moteki H, Kimura M, Kitagishi H, Arce F Jr, See GL, Tanikawa T, Inoue Y.  Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins.  ACS Omega  2022  7(35):31233-31245  PubMed ID: 36092555   DOI: 10.1021/acsomega.2c03489
20947  Ishida-Ishihara S, Takada R, Furusawa K, Ishihara S, Haga H.  Improvement of the cell viability of hepatocytes cultured in three-dimensional collagen gels using pump-free perfusion driven by water level difference.  Sci Rep  2022  12(1):20269  PubMed ID: 36434099   DOI: 10.1038/s41598-022-24423-y
13179  Hayakawa EH, Kato H, Nardone GA, Usukura J.  A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells.  Parasitol Int  2021    PubMed ID: 32853776   DOI: 10.1016/j.parint.2020.102179
13396  Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.  Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis.  Biochem Biophys Rep  2021    PubMed ID: 33392396   DOI: 10.1016/j.bbrep.2020.100882
13418  Abiko Y, Aoki H, Kumagai Y.  Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome.  Toxicol Appl Pharmacol  2021    PubMed ID: 33428920   DOI: 10.1016/j.taap.2020.115392
20024  Yamazaki T, Tokiwa T.  Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.  Hum Cell  2021    PubMed ID: 33495943   DOI: 10.1007/s13577-021-00487-2
20049  Abiko Y, Katayama Y, Akiyama M, Kumagai Y.  Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts.  Food Chem Toxicol  2021  150:112061  PubMed ID: 33587975   DOI: 10.1016/j.fct.2021.112061
20081  Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.  The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.  Oncotarget  2021  12(4):333-343  PubMed ID: 33659044   DOI: 10.18632/oncotarget.27881
20119  Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H.  Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication.  Commun Biol  2021  4(1):425  PubMed ID: 33782534   DOI: 10.1038/s42003-021-01880-1
20166  Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.  CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.  Hepatol Commun  2021  5(2):334-348  PubMed ID: 33553979   DOI: 10.1002/hep4.1643
20204  Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C.  Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells.  Monoclon Antib Immunodiagn Immunother  2021  40(3):118-123  PubMed ID: 34076498   DOI: 10.1089/mab.2020.0046
20281  Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M.  Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten.  J Food Sci Technol  2021  58(9):3504-3513  PubMed ID: 34366467   DOI: 10.1007/s13197-021-05040-5
20288  Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y.  Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.  Int J Mol Sci  2021  22(6)  PubMed ID: 33799598   DOI: 10.3390/ijms22062843
20384  Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.  Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.  Mol Pharm  2021    PubMed ID: 34734526   DOI: 10.1021/acs.molpharmaceut.1c00490
20502  Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K.  PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.  Cells  2021  10(12)  PubMed ID: 34944058   DOI: 10.3390/cells10123550
16100  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Yamamoto Y, Morimura R, Ikoma H, Okamoto K, Kamiya M, Urano Y, Otsuji E.  Rapid fluorescence imaging of human hepatocellular carcinoma using the β-galactosidase-activatable fluorescence probe SPiDER-βGal  Sci Rep  2021  11(1):1794  PubMed ID: 34504174   DOI: 10.1038/s41598-021-97073-1
16205  Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.  Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway  J Nutr Biochem  2021  89:108573  PubMed ID: 33388347   DOI: 10.1016/j.jnutbio.2020.108573
16370  Enokiya T, Nishikawa K, Hamada Y, Ikemura K, Sugimura Y, Okuda M.  Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene  Basic Clin Pharmacol Toxicol   2021  128(3):525-533  PubMed ID: 33248001   DOI: 10.1111/bcpt.13539
16372  Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai  Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment  Journal of Crystal Growth  2021  572:126265    DOI: 10.1016/j.jcrysgro.2021.126265
20621  Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.  Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.  J Toxicol Sci  2021  46(12):569-587  PubMed ID: 34853243   DOI: 10.2131/jts.46.569
12057  Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.  Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver.  Biochim Biophys Acta Mol Basis Dis  2020    PubMed ID: 32088316   DOI: 10.1016/j.bbadis.2020.165731
12094  Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H.  Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet.  Tissue Eng Part C Methods  2020    PubMed ID: 32186996   DOI: 10.1089/ten.tec.2019.0330
12198  Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki   Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells  Nature Communications  2020  11:5292   PubMed ID: 33087715   DOI: 10.1038/s41467-020-19041-z
12439  Fujiyama Y, Kumamoto Y, Nishizawa N, Nakamoto S, Harada H, Yokota K, Tanaka Y, Igarashi K, Oiki H, Okuwaki K, Iwai T, Kajita S, Takahashi H, Tajima H, Kaizu T, Sasaki J, Watanabe M, Yamashita K.  Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN)  Ann Surg Oncol   2020  27(10):4007-4016  PubMed ID: 32144623   DOI: 10.1245/s10434-020-08291-2
12963  Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M.  Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation.  ACS Omega  2020    PubMed ID: 32905425   DOI: 10.1021/acsomega.0c02385
13027  Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T.  Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells.  In Vitro Cell Dev Biol Anim  2020    PubMed ID: 32394241   DOI: 10.1007/s11626-020-00451-8
13053  Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ.  TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells.  Cell Death Dis  2020    PubMed ID: 32471991   DOI: 10.1038/s41419-020-2618-6
13073  Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.  Free Radic Biol Med  2020    PubMed ID: 32553752   DOI: 10.1016/j.freeradbiomed.2020.06.005
13103  Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J.  Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.  NPJ Precis Oncol  2020    PubMed ID: 32656360   DOI: 10.1038/s41698-020-0125-y
13189  Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y.  A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract.  Food Chem Toxicol  2020    PubMed ID: 32871193   DOI: 10.1016/j.fct.2020.111706
13191  Xu DQ, Yuan XJ, Hirayama M, Toyoda H.  Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway.  In Vivo  2020    PubMed ID: 32871763   DOI: 10.21873/invivo.12051
13241  Yamashita R, Komaki Y, Yang G, Ibuki Y.  Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.  Mutat Res  2020    PubMed ID: 33198939   DOI: 10.1016/j.mrgentox.2020.503273
13290  Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H.  Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential.  Sci Rep  2020    PubMed ID: 33060804   DOI: 10.1038/s41598-020-74590-z
13528  Ishizawa K, Togami K, Tada H, Chono S.  Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers  J Pharm Sci   2020  109(12):3608-3616  PubMed ID: 32926888   DOI: 10.1016/j.xphs.2020.08.028
13635  Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K.  Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system  Xenobiotica  2020  50(6):654-662  PubMed ID: 31631733   DOI: 10.1080/00498254.2019.1683258
14866  Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I.  Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver  Mol Pharm  2020  17(8):2821-2830  PubMed ID: 32602343   DOI: 10.1021/acs.molpharmaceut.0c00193
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272   DOI: 10.1016/j.molcel.2019.09.009
11522  Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H.  Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.  J. Cell. Physiol.  2019    PubMed ID: 30993729   DOI: 10.1002/jcp.28625
11538  Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.  Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.  Neoplasia  2019    PubMed ID: 31042624   DOI: 10.1016/j.neo.2019.03.007
11857  Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y.  Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists.  Molecules  2019    PubMed ID: 31137814   DOI: 10.3390/molecules24102019
6837  Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S.  Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.  Anticancer Agents Med Chem  2019  19(13):1651-1657  PubMed ID: 31038081   DOI: 10.2174/1871520619666190416101622
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114   DOI: 10.3892/ol.2018.9869
9759  Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito  Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells  Fundamental Toxicological Sciences  2019  6 :281-286    DOI: 10.2131/fts.6.281
9763  Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita  Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells  Biochem Biophys Res Commun  2019  509(1):268-274  PubMed ID: 30583860   DOI: 10.1016/j.bbrc.2018.12.118
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920   DOI: 10.18433/jpps30444
11048  Yuta Kurashina, Ryo Sato, Hiroaki Onoe  Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly  APL Bioeng  2019  3(4):046101  PubMed ID: 31737859   DOI: 10.1063/1.5109966
11057  Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda  Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein  Sci Rep  2019  9(1):20359  PubMed ID: 31889141   DOI: 10.1038/s41598-019-56900-2
12238  Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond  Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy  Anal Chem  2019  91(4):2710-2718  PubMed ID: 30664349   DOI: 10.1021/acs.analchem.8b04393
12365  Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K.  Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro  Drug Metab Pharmacokinet  2019  34(4):272-279  PubMed ID: 31280915   DOI: 10.1016/j.dmpk.2019.04.005
12443  Kojima K, Nakamura T, Ooizumi Y, Igarashi K, Tanaka T, Yokoi K, Ishii S, Nishizawa N, Katoh H, Kosaka Y, Sato T, Watanabe M, Yamashita K.  Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer  PLoS One  2019  14(1):e0211108  PubMed ID: 30677088   DOI: 10.1371/journal.pone.0211108
12444  Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T.  Plasmodium RON12 localizes to the rhoptry body in sporozoites  Parasitol Int  2019  68(1):17-23  PubMed ID: 30290224   DOI: 10.1016/j.parint.2018.10.001
12445  Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T.  Glass-based organ-on-a-chip device for restricting small molecular absorption  J Biosci Bioeng  2019  127(5):641-646  PubMed ID: 30473393   DOI: 10.1016/j.jbiosc.2018.10.019
12472  Hara M, Takeba Y, Iiri T, Ohta Y, Ootaki M, Watanabe M, Watanabe D, Koizumi S, Otsubo T, Matsumoto N.  Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway  Cancer Sci  2019  110(1):235-244  PubMed ID: 30390393   DOI: 10.1111/cas.13861
12517  Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.  Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)  Nat Prod Res  2019  33(2):189-195  PubMed ID: 29457741   DOI: 10.1080/14786419.2018.1440229
10634  Hara J, Tanaka Y, Kaneko H, Itoh Y, Ikegaya H.  Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains.  Arch. Virol.  2018  163:633-637  PubMed ID: 29198036   DOI: 10.1007/s00705-017-3665-x
10641  Kaji K, Nishimura N, Seki K, Sato S, Saikawa S, Nakanishi K, Furukawa M, Kawaratani H, Kitade M, Moriya K, Namisaki T, Yoshiji H.  Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake.  Int. J. Cancer  2018  142:1712-1722  PubMed ID: 29205334   DOI: 10.1002/ijc.31193
10660  Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M.  β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.  Environ Sci Pollut Res Int  2018  25:6320-6328  PubMed ID: 29247416   DOI: 10.1007/s11356-017-0977-z
10774  Yajima Y, Lee CN, Yamada M, Utoh R, Seki M.  Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers.  J. Biosci. Bioeng.  2018  126(1):111-118  PubMed ID: 29502942   DOI: 10.1016/j.jbiosc.2018.01.022
10786  He Q, Okajima T, Onoe H, Subagyo A, Sueoka K, Kuribayashi-Shigetomi K.  Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures.  Sci Rep  2018  8:4556  PubMed ID: 29540810   DOI: 10.1038/s41598-018-22598-x
10847  Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K.  Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.  PLoS ONE  2018  13:e0194785  PubMed ID: 29746493   DOI: 10.1371/journal.pone.0194785
11025    Isolation of activating factors of serotonin N-acetyltransferase from rice peptides  Journal of Functional Foods  2018  41, 148-154    DOI: 10.1016/j.jff.2017.12.051
11089  Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S.  Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides.  PLoS ONE  2018  13(6):e0198264  PubMed ID: 29856876   DOI: 10.1371/journal.pone.0198264
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10236  Sudo K, Niikura K, Iwaki K, Kohyama S, Fujiwara K, Doi N.  Human-derived fusogenic peptides for the intracellular delivery of proteins.  J Control Release  2017  255:1-11  PubMed ID: 28385674   DOI: 10.1016/j.jconrel.2017.03.398
10351  Nakashima KI, Ogiwara T, Hirai T, Tanaka T, Murata H, Kaburagi K, Fujii-Kuriyama Y, Hayashi H, Inoue M.  Gerontoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist.  Bioorg. Med. Chem.  2017  25:4253-4258  PubMed ID: 28662965   DOI: 10.1016/j.bmc.2017.05.047
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10435  Tung NH, Uto T, Hai NT, Li G, Shoyama Y.  Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines.  Pharmacogn Mag  2017  13:459-462  PubMed ID: 28839372   DOI: 10.4103/pm.pm_353_16
10446  Chen Z, Wu Y, Ma YS, Kobayashi Y, Zhao YY, Miura Y, Chiba H, Hui SP.  Profiling of cardiolipins and their hydroperoxides in HepG2 cells by LC/MS.  Anal Bioanal Chem  2017  409:5735-5745  PubMed ID: 28762068   DOI: 10.1007/s00216-017-0515-3
10466  Machihara K, Tanaka H, Hayashi Y, Murakami I, Namba T.  Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78.  Biochem. Biophys. Res. Commun.  2017  492:33-40  PubMed ID: 28811106   DOI: 10.1016/j.bbrc.2017.08.042
10470  Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J.  Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.  Sci Rep  2017  7:8253  PubMed ID: 28811612   DOI: 10.1038/s41598-017-08899-7
10478  Fukushima T, Hara-Yamamura H, Nakashima K, Tan LC, Okabe S.  Multiple-endpoints gene alteration-based (MEGA) assay: A toxicogenomics approach for water quality assessment of wastewater effluents.  Chemosphere  2017  188:312-319  PubMed ID: 28888119   DOI: 10.1016/j.chemosphere.2017.08.107
10488  Oda Y, Hidaka M, Suzuki A.  Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells.  Biol. Pharm. Bull.  2017  40:2005-2009  PubMed ID: 28855448   DOI: 10.1248/bpb.b17-00457
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10494  Toda M, Totoki T, Nakamura C, Yasuma T, D' Alessandro-Gabazza CN, Mifuji-Moroka R, Nishihama K, Iwasa M, Horiki N, Gabazza EC, Takei Y.  Low dose of alcohol attenuates pro-atherosclerotic activity of thrombin.  Atherosclerosis  2017  265:215-224  PubMed ID: 28923781   DOI: 10.1016/j.atherosclerosis.2017.09.005
10495  Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.  Sake lees hydrolysate protects against acetaminophen-induced hepatotoxicity via activation of the Nrf2 antioxidant pathway.  J Clin Biochem Nutr  2017  61:203-209  PubMed ID: 29203962   DOI: 10.3164/jcbn.17-21
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10531  Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, Yamana Y, Fujita K, Sakamoto T, Nomura T, Yoneyama H, Kobara H, Mori H, Iwama H, Okano K, Suzuki Y, Masaki T.  Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest.  Oncol. Rep.  2017  38:2825-2835  PubMed ID: 29048654   DOI: 10.3892/or.2017.5977
10552  Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.  Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.  Am. J. Chin. Med.  2017  45:1497-1511  PubMed ID: 29025293   DOI: 10.1142/S0192415X17500811
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10990    CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element  Fundamental Toxicological Sciences  2017  4, 229-239    DOI: 10.2131/fts.4.229
9497  Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita  A New Sarasinoside Congener, Sarasinoside M 2, From a Marine Sponge Collected in the Solomon Islands  Biosci Biotechnol Biochem  2017  81(2):222-225  PubMed ID: 27760495   DOI: 10.1080/09168451.2016.1246172
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9717  Miyamae Y, Nishito Y, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, Nagao M.  Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line.  Biochem. Biophys. Res. Commun.  2016  477:40-6  PubMed ID: 27270032   DOI: 10.1016/j.bbrc.2016.06.018
9786  Sakai S, Nomura K, Mochizuki K, Taya M.  Anchoring PEG-oleate to cell membranes stimulates reactive oxygen species production.  Colloids Surf B Biointerfaces  2016  147:336-342  PubMed ID: 27544656   DOI: 10.1016/j.colsurfb.2016.08.013
9812  Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.  Molecular hydrogen suppresses activated Wnt/β-catenin signaling.  Sci Rep  2016  6:31986  PubMed ID: 27558955   DOI: 10.1038/srep31986
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12288  Kung-Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying-Chu Lin, Ming-Ho Tsai, Kenly Wuputra, Yen-Liang Lee, Chia-Chen Ku, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Chun-Chieh Wu, Chee-Yin Chai, Richard Eckner, Chen-Lung Steve Lin, Sophie S-W Wang, Deng-Chyang Wu, Chang-Shen Lin, Kazunari K Yokoyama  Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer  Stem Cells  2016  34(11):2613-2624  PubMed ID: 27341307   DOI: 10.1002/stem.2447
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14088  Yoshitaka Koseki, Yoshikazu Ikuta, Takaaki Kamishima, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai  Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of Nano-Prodrug  Bulletin of the Chemical Society of Japan  2016  89:540–545    DOI: 10.1246/bcsj.20150405
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7219  Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T.  In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.  Stem Cell Res Ther  2015  6:171  PubMed ID: 26358689   DOI: 10.1186/s13287-015-0154-6
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