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20483
Koide R, Hirane N, Kambe D, Yokoi Y, Otaki M, Nishimura SI.
Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis.
Biomaterials
2022
280:121314
PubMed ID: 34906850
DOI: 10.1016/j.biomaterials.2021.121314
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16114
Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK.
Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts
Cell Biol Toxicol
2022
Mar 15
PubMed ID: 33723743
DOI: 10.1007/s10565-021-09592-2
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16273
Sakai S, Kotani T, Harada R, Goto R, Morita T, Bouissil S, Dubessay P, Pierre G, Michaud P, El Boutachfaiti R, Nakahata M, Kojima M, Petit E, Delattre C.
Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks
Carbohydr Polym
2022
277:118820
PubMed ID: 34893237
DOI: 10.1016/j.carbpol.2021.118820
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20613
Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.
Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.
Analyst
2022
PubMed ID: 35297918
DOI: 10.1039/d2an00052k
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20752
Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.
Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.
J Toxicol Sci
2022
47(6):249-255
PubMed ID: 35650141
DOI: 10.2131/jts.47.249
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20753
Luong NC, Abiko Y, Aoki H, Kumagai Y.
A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones.
Biol Pharm Bull
2022
45(6):798-802
PubMed ID: 35650106
DOI: 10.1248/bpb.b22-00080
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16739
Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T.
Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles
J Biotechnol
2022
354:34-44
PubMed ID: 35724765
DOI: 10.1016/j.jbiotec.2022.06.006
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20784
Abiko Y, Taguchi K, Hisamori M, Hiyoshi-Arai K, Luong NC, Toriba A, Kumagai Y.
Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor.
Chem Res Toxicol
2022
PubMed ID: 35862866
DOI: 10.1021/acs.chemrestox.2c00174
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16971
Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M.
Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells
Int J Mol Sci
2022
23(15):8660
PubMed ID: 35955793
DOI: 10.3390/ijms23158660
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20862
Tachikawa R, Saito H, Moteki H, Kimura M, Kitagishi H, Arce F Jr, See GL, Tanikawa T, Inoue Y.
Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins.
ACS Omega
2022
7(35):31233-31245
PubMed ID: 36092555
DOI: 10.1021/acsomega.2c03489
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20947
Ishida-Ishihara S, Takada R, Furusawa K, Ishihara S, Haga H.
Improvement of the cell viability of hepatocytes cultured in three-dimensional collagen gels using pump-free perfusion driven by water level difference.
Sci Rep
2022
12(1):20269
PubMed ID: 36434099
DOI: 10.1038/s41598-022-24423-y
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13179
Hayakawa EH, Kato H, Nardone GA, Usukura J.
A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells.
Parasitol Int
2021
PubMed ID: 32853776
DOI: 10.1016/j.parint.2020.102179
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13396
Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.
Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis.
Biochem Biophys Rep
2021
PubMed ID: 33392396
DOI: 10.1016/j.bbrep.2020.100882
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13418
Abiko Y, Aoki H, Kumagai Y.
Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome.
Toxicol Appl Pharmacol
2021
PubMed ID: 33428920
DOI: 10.1016/j.taap.2020.115392
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20024
Yamazaki T, Tokiwa T.
Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.
Hum Cell
2021
PubMed ID: 33495943
DOI: 10.1007/s13577-021-00487-2
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20049
Abiko Y, Katayama Y, Akiyama M, Kumagai Y.
Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts.
Food Chem Toxicol
2021
150:112061
PubMed ID: 33587975
DOI: 10.1016/j.fct.2021.112061
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20081
Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.
The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.
Oncotarget
2021
12(4):333-343
PubMed ID: 33659044
DOI: 10.18632/oncotarget.27881
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20119
Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H.
Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication.
Commun Biol
2021
4(1):425
PubMed ID: 33782534
DOI: 10.1038/s42003-021-01880-1
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20166
Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.
CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.
Hepatol Commun
2021
5(2):334-348
PubMed ID: 33553979
DOI: 10.1002/hep4.1643
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20204
Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C.
Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells.
Monoclon Antib Immunodiagn Immunother
2021
40(3):118-123
PubMed ID: 34076498
DOI: 10.1089/mab.2020.0046
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20281
Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M.
Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten.
J Food Sci Technol
2021
58(9):3504-3513
PubMed ID: 34366467
DOI: 10.1007/s13197-021-05040-5
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20288
Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y.
Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.
Int J Mol Sci
2021
22(6)
PubMed ID: 33799598
DOI: 10.3390/ijms22062843
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20384
Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.
Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.
Mol Pharm
2021
PubMed ID: 34734526
DOI: 10.1021/acs.molpharmaceut.1c00490
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20502
Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K.
PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.
Cells
2021
10(12)
PubMed ID: 34944058
DOI: 10.3390/cells10123550
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16100
Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Yamamoto Y, Morimura R, Ikoma H, Okamoto K, Kamiya M, Urano Y, Otsuji E.
Rapid fluorescence imaging of human hepatocellular carcinoma using the β-galactosidase-activatable fluorescence probe SPiDER-βGal
Sci Rep
2021
11(1):1794
PubMed ID: 34504174
DOI: 10.1038/s41598-021-97073-1
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16205
Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.
Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway
J Nutr Biochem
2021
89:108573
PubMed ID: 33388347
DOI: 10.1016/j.jnutbio.2020.108573
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16370
Enokiya T, Nishikawa K, Hamada Y, Ikemura K, Sugimura Y, Okuda M.
Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene
Basic Clin Pharmacol Toxicol
2021
128(3):525-533
PubMed ID: 33248001
DOI: 10.1111/bcpt.13539
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16372
Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai
Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment
Journal of Crystal Growth
2021
572:126265
DOI: 10.1016/j.jcrysgro.2021.126265
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20621
Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.
J Toxicol Sci
2021
46(12):569-587
PubMed ID: 34853243
DOI: 10.2131/jts.46.569
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12057
Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.
Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver.
Biochim Biophys Acta Mol Basis Dis
2020
PubMed ID: 32088316
DOI: 10.1016/j.bbadis.2020.165731
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12094
Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H.
Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet.
Tissue Eng Part C Methods
2020
PubMed ID: 32186996
DOI: 10.1089/ten.tec.2019.0330
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12198
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki
Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
Nature Communications
2020
11:5292
PubMed ID: 33087715
DOI: 10.1038/s41467-020-19041-z
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12439
Fujiyama Y, Kumamoto Y, Nishizawa N, Nakamoto S, Harada H, Yokota K, Tanaka Y, Igarashi K, Oiki H, Okuwaki K, Iwai T, Kajita S, Takahashi H, Tajima H, Kaizu T, Sasaki J, Watanabe M, Yamashita K.
Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN)
Ann Surg Oncol
2020
27(10):4007-4016
PubMed ID: 32144623
DOI: 10.1245/s10434-020-08291-2
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12963
Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M.
Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation.
ACS Omega
2020
PubMed ID: 32905425
DOI: 10.1021/acsomega.0c02385
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13027
Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T.
Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells.
In Vitro Cell Dev Biol Anim
2020
PubMed ID: 32394241
DOI: 10.1007/s11626-020-00451-8
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13053
Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ.
TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells.
Cell Death Dis
2020
PubMed ID: 32471991
DOI: 10.1038/s41419-020-2618-6
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13073
Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.
Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.
Free Radic Biol Med
2020
PubMed ID: 32553752
DOI: 10.1016/j.freeradbiomed.2020.06.005
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13103
Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J.
Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.
NPJ Precis Oncol
2020
PubMed ID: 32656360
DOI: 10.1038/s41698-020-0125-y
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13189
Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y.
A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract.
Food Chem Toxicol
2020
PubMed ID: 32871193
DOI: 10.1016/j.fct.2020.111706
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13191
Xu DQ, Yuan XJ, Hirayama M, Toyoda H.
Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway.
In Vivo
2020
PubMed ID: 32871763
DOI: 10.21873/invivo.12051
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13241
Yamashita R, Komaki Y, Yang G, Ibuki Y.
Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.
Mutat Res
2020
PubMed ID: 33198939
DOI: 10.1016/j.mrgentox.2020.503273
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13290
Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H.
Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential.
Sci Rep
2020
PubMed ID: 33060804
DOI: 10.1038/s41598-020-74590-z
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13528
Ishizawa K, Togami K, Tada H, Chono S.
Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers
J Pharm Sci
2020
109(12):3608-3616
PubMed ID: 32926888
DOI: 10.1016/j.xphs.2020.08.028
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13635
Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K.
Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system
Xenobiotica
2020
50(6):654-662
PubMed ID: 31631733
DOI: 10.1080/00498254.2019.1683258
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14866
Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I.
Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver
Mol Pharm
2020
17(8):2821-2830
PubMed ID: 32602343
DOI: 10.1021/acs.molpharmaceut.0c00193
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5357
Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.
AUTACs: Cargo-Specific Degraders Using Selective Autophagy.
Mol Cell
2019
76(5):797-810
PubMed ID: 31606272
DOI: 10.1016/j.molcel.2019.09.009
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11522
Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H.
Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.
J. Cell. Physiol.
2019
PubMed ID: 30993729
DOI: 10.1002/jcp.28625
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11538
Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.
Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.
Neoplasia
2019
PubMed ID: 31042624
DOI: 10.1016/j.neo.2019.03.007
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11857
Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y.
Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists.
Molecules
2019
PubMed ID: 31137814
DOI: 10.3390/molecules24102019
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6837
Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S.
Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.
Anticancer Agents Med Chem
2019
19(13):1651-1657
PubMed ID: 31038081
DOI: 10.2174/1871520619666190416101622
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9758
Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai
Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line
Oncol Lett
2019
17(2):2431-2440
PubMed ID: 30719114
DOI: 10.3892/ol.2018.9869
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9759
Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito
Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells
Fundamental Toxicological Sciences
2019
6 :281-286
DOI: 10.2131/fts.6.281
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9763
Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita
Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells
Biochem Biophys Res Commun
2019
509(1):268-274
PubMed ID: 30583860
DOI: 10.1016/j.bbrc.2018.12.118
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11906
Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
J Pharm Pharm Sci
2019
PubMed ID: 31804920
DOI: 10.18433/jpps30444
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11048
Yuta Kurashina, Ryo Sato, Hiroaki Onoe
Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly
APL Bioeng
2019
3(4):046101
PubMed ID: 31737859
DOI: 10.1063/1.5109966
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11057
Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda
Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein
Sci Rep
2019
9(1):20359
PubMed ID: 31889141
DOI: 10.1038/s41598-019-56900-2
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12238
Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond
Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy
Anal Chem
2019
91(4):2710-2718
PubMed ID: 30664349
DOI: 10.1021/acs.analchem.8b04393
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12365
Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K.
Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro
Drug Metab Pharmacokinet
2019
34(4):272-279
PubMed ID: 31280915
DOI: 10.1016/j.dmpk.2019.04.005
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12443
Kojima K, Nakamura T, Ooizumi Y, Igarashi K, Tanaka T, Yokoi K, Ishii S, Nishizawa N, Katoh H, Kosaka Y, Sato T, Watanabe M, Yamashita K.
Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer
PLoS One
2019
14(1):e0211108
PubMed ID: 30677088
DOI: 10.1371/journal.pone.0211108
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12444
Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T.
Plasmodium RON12 localizes to the rhoptry body in sporozoites
Parasitol Int
2019
68(1):17-23
PubMed ID: 30290224
DOI: 10.1016/j.parint.2018.10.001
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12445
Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T.
Glass-based organ-on-a-chip device for restricting small molecular absorption
J Biosci Bioeng
2019
127(5):641-646
PubMed ID: 30473393
DOI: 10.1016/j.jbiosc.2018.10.019
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12472
Hara M, Takeba Y, Iiri T, Ohta Y, Ootaki M, Watanabe M, Watanabe D, Koizumi S, Otsubo T, Matsumoto N.
Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway
Cancer Sci
2019
110(1):235-244
PubMed ID: 30390393
DOI: 10.1111/cas.13861
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12517
Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.
Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)
Nat Prod Res
2019
33(2):189-195
PubMed ID: 29457741
DOI: 10.1080/14786419.2018.1440229
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10634
Hara J, Tanaka Y, Kaneko H, Itoh Y, Ikegaya H.
Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains.
Arch. Virol.
2018
163:633-637
PubMed ID: 29198036
DOI: 10.1007/s00705-017-3665-x
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10641
Kaji K, Nishimura N, Seki K, Sato S, Saikawa S, Nakanishi K, Furukawa M, Kawaratani H, Kitade M, Moriya K, Namisaki T, Yoshiji H.
Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake.
Int. J. Cancer
2018
142:1712-1722
PubMed ID: 29205334
DOI: 10.1002/ijc.31193
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10660
Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M.
β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.
Environ Sci Pollut Res Int
2018
25:6320-6328
PubMed ID: 29247416
DOI: 10.1007/s11356-017-0977-z
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Yajima Y, Lee CN, Yamada M, Utoh R, Seki M.
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2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
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DOI: 10.1109/mhs.2016.7824174
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14165
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Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood
J Am Chem Soc
2016
138(16):5417-25
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7128
Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.
Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.
J Pharm Pharm Sci
2015
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7219
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Stem Cell Res Ther
2015
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7238
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Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection.
PLoS ONE
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10:e0136381
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7257
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2015
28:1803-14
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7278
Yamaori S, Kinugasa Y, Jiang R, Takeda S, Yamamoto I, Watanabe K.
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Life Sci.
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7324
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Int J Pharm
2015
490:316-23
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7474
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Biochem. Biophys. Res. Commun.
2015
458:920-7
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7553
Priscilla Boccia, Claudia Meconi, Elena Sturchio, Salvatore Margiotta, Pietro Ragone, Vito Summa
Natural geochemical risk in the Pollino Massif: a case-study of chromium.
Frontiers in Genetics
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7568
Tung NH, Uto T, Morinaga O, Shoyama Y
Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.
Natural Product Sciences
2015
21:71-75
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10187
Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
Mutagenicity of Modelled-Heat-Treated Meat Extracts: Mutagenicity Assay, Analysis and Mechanism of Mutagenesis
Jpn J Vet Res
2015
63(4):173-82
PubMed ID: 26753243
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14962
Kazuya Furusawa, Masayuki Tsuchida, Saki Yahata
Construction of engineered liver cancer tissues with multichannel collagen gel
2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
2015
2015-11
DOI: 10.1109/MHS.2015.7438238
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15144
Kawase A, Hata S, Takagi M, Iwaki M.
Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption
J Pharm Pharm Sci
2015
18(5):765-7
PubMed ID: 26670369
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15145
Mira A, Shimizu K.
In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and its Isolated Compounds
Pharmacogn Mag
2015
11(Suppl 4):S564-9
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15159
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Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers
Proc Natl Acad Sci U S A
2015
112(29):E3816-25
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15195
Ohtera A, Miyamae Y, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M.
Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy
ACS Chem Biol
2015
10(12):2794-804
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17094
Kondo Y, Yoshihashi S, Mimori K, Ogihara R, Kanehama Y, Maki Y, Enosawa S, Kurose K, Iwao T, Nakamura K, Matsunaga T.
Selective culture method for hepatocyte-like cells differentiated from human induced pluripotent stem cells
Drug Metab Pharmacokinet
2014
29(5):407-13
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Tokumoto M, Kutsukake N, Yamanishi E, Katsuta D, Anan Y, Ogra Y.
Arsenic (+3 oxidation state) methyltransferase is a specific but replaceable factor against arsenic toxicity
Toxicol Rep
2014
1:589-595
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17125
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Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells
PLoS One
2014
9(8):e104123
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17130
Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S.
An efficient method for differentiation of human induced pluripotent stem cells into hepatocyte-like cells retaining drug metabolizing activity
Drug Metab Pharmacokinet
2014
29(3):237-43
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Evaluation of whole wastewater effluent impacts on HepG2 using DNA microarray-based transcriptome analysis
Environ Sci Technol
2013
47(10):5425-32
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Acetaldehyde-induced cytotoxicity involves induction of spermine oxidase at the transcriptional level
Toxicology
2013
310:1-7
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12539
Kawano Y, Nagata M, Kohno T, Ichimiya A, Iwakiri T, Okumura M, Arimori K.
Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
Biol Pharm Bull
2012
35(3):400-7
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All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells
Biochem Biophys Res Commun
2012
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Dose of 3-methylcholanthrene enhances vitamin C accumulation and mRNA expression of its transporter in the liver of ODS rats and in HepG2 cells
J Biochem Mol Toxicol
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Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive
Dokkyo Journal of Medical Sciences
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ACE in three tunicae of rat aorta: expression in smooth muscle and effect of renovascular hypertension.
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