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Cell No. : Cell Name
RCB1886 : Hep G2  update : 2024/10/10
CommentHuman cell line derived from hepatoblastoma. Secretes several products such as albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. TKG0205 (Deposited from Tohoku Univ.). Information
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0205 HepG2
Animal _human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Male
Age at sampling 15 years
Tissue liver
Disease name hepatocyte carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0205)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0027
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Animal PCR OK
Virus (HBV) (-)
Virus (HCV) (-)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 5
User's Publication 214


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Reference
11987  Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles  Hep G2 is a hepatoblastoma-derived cell line  Hum Pathol  2009  40(10):1512-5  PubMed ID: 19751877   DOI: 10.1016/j.humpath.2009.07.003
1156  Darlington GJ, Kelly JH, Buffone GJ.  Growth and hepatospecific gene expression of human hepatoma cells in a defined medium  In Vitro Cell Dev Biol  1987  23(5):349-54.  PubMed ID: 3034851   DOI: 10.1007/BF02620991
1155  Knowles, B B, Howe, C C, Aden, D P  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.  Science  1980  209:497-9  PubMed ID: 6248960   DOI: 10.1126/science.6248960
4984  Diamond L1, Kruszewski F, Aden DP, Knowles BB, Baird WM.  Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.  Carcinogenesis  1980  1(10):871-5  PubMed ID: 11219860   DOI: 10.1093/carcin/1.10.871
465  Aden, D P, Fogel A, Plotkin S, Damjanov I, Knowles, B B  Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.  Nature  1979  282:615-6  PubMed ID: 233137   DOI: 10.1038/282615a0

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User's Publication
19845  Uchida Y, Ferdousi F, Takahashi S, Isoda H.  Comprehensive Transcriptome Profiling of Antioxidant Activities by Glutathione in Human HepG2 Cells  Molecules  2024  29(5):1090  PubMed ID: 38474603   DOI: 10.3390/molecules29051090
19882  Kaito S, Takeshita JI, Iwata M, Sasaki T, Hosaka T, Shizu R, Yoshinari K.  Utility of human cytochrome P450 inhibition data in the assessment of drug-induced liver injury  Xenobiotica  2024  1-30  PubMed ID: 38315106   DOI: 10.1080/00498254.2024.2312505
19985  Shimura M, Higashi-Kuwata N, Fujiwara A, Taniguchi M, Ichinose T, Hamano F, Uematsu M, Inoue T, Matsuyama S, Suzuki T, Ghosh AK, Shindou H, Shimuzu T, Mitsuya H.  A lipid index for risk of hyperlipidemia caused by anti-retroviral drugs  Antiviral Res  2024  3:223:105819  PubMed ID: 38272319   DOI: 10.1016/j.antiviral.2024.105819
21713  Furuno K, Suzuki K, Sakai S.  Transduction and Genome Editing of the Heart with Adeno-Associated Viral Vectors Loaded onto Electrospun Polydioxanone Nonwoven Fabrics.  Biomolecules  2024  14(4)  PubMed ID: 38672522   DOI: 10.3390/biom14040506
21943  Yanagisawa H, Maeda H, Noguchi I, Tanaka M, Wada N, Nagasaki T, Kobayashi K, Kanazawa G, Taguchi K, Chuang VTG, Sakai H, Nakashima H, Kinoshita M, Kitagishi H, Iwakiri Y, Sasaki Y, Tanaka Y, Otagiri M, Watanabe H, Maruyama T.  Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation.  Redox Biol  2024  76:103314  PubMed ID: 39163766   DOI: 10.1016/j.redox.2024.103314
21944  Ogiwara N, Nakano T, Baba K, Noguchi H, Masuda T, Takai M.  High-Quality Three-Dimensionally Cultured Cells Using Interfaces of Diblock Copolymers Containing Different Ratios of Zwitterionic N-Oxides.  ACS Appl Mater Interfaces  2024    PubMed ID: 39160767   DOI: 10.1021/acsami.4c10118
21949  Sato T, Shizu R, Baba R, Ooka A, Hosaka T, Kanno Y, Yoshinari K.  Pregnane X receptor inhibits the transdifferentiation of hepatic stellate cells by downregulating periostin expression.  Biochem J  2024    PubMed ID: 39171361   DOI: 10.1042/BCJ20240172
21972  Ogawa T, Terada T.  The Beneficial Effect of Brazilian Propolis for Liver Damage through Endoplasmic Reticulum Stress  Biol Pharm Bull  2024  47(7):1265-1274  PubMed ID: 38987175   DOI: 10.1248/bpb.b24-00092
21991  Kasano-Camones CI, Yokota S, Ohashi M, Sakamoto N, Ito D, Saito Y, Uchida R, Ninomiya K, Inoue Y.  Hepatocyte nuclear factor 4α is a critical factor for the production of complement components in the liver.  In Vitro Cell Dev Biol Anim  2024    PubMed ID: 39285151   DOI: 10.1007/s11626-024-00972-6
21992  Mitsutani M, Yokoyama M, Hano H, Morita A, Matsushita M, Tagami T, Moriyama K.  Growth hormone is involved in GATA1 gene expression via STAT5B in human erythroleukemia and monocytic cell lines.  Blood Cells Mol Dis  2024  110:102894  PubMed ID: 39303396   DOI: 10.1016/j.bcmd.2024.102894
22012  Adachi M, Kumagai T, Hosho K, Nagata K, Fujiyoshi M, Shimada M.  Exploring Acute Liver Damage: Slimming Health Foods and CYP3A4 Induction.  Yonago Acta Med  2024  67(2):124-134  PubMed ID: 38803590   DOI: 10.33160/yam.2024.05.004
22023  Okami K, Fumoto S, Yamashita M, Nakashima M, Miyamoto H, Kawakami S, Nishida K.  One-Step Formation Method of Plasmid DNA-Loaded, Extracellular Vesicles-Mimicking Lipid Nanoparticles Based on Nucleic Acids Dilution-Induced Assembly.  Cells  2024  13(14):  PubMed ID: 39056764   DOI: 10.3390/cells13141183
19583  Tabei Y, Abe H, Suzuki S, Takeda N, Arai JI, Nakajima Y.  Sedanolide Activates KEAP1-NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death  Int J Mol Sci  2023  24(22):16532  PubMed ID: 38003720   DOI: 10.3390/ijms242216532
19652  oko Takeo, Kai Sakurai, Noboru Furuya, Kyota Yoshinaga, Takenori Shimamura, Satoru Egawa, Hisao Kiuchi, Hidekazu Mimura, Haruhiko Ohashi, Yoshihisa Harada, Mari Shimura, Takashi Kimura  Development of soft X-ray ptychography and fluorescence microscopy system using total-reflection wolter mirror and application to measurement of drug-treated mammalian cells  Journal of Electron Spectroscopy and Related Phenomena  2023  237:147380    DOI: 10.1016/j.elspec.2023.147380
19659  Goto R, Nakahata M, Delattre C, Petit E, El Boutachfaiti R, Sakai S.  Fabrication of cell-laden microbeads and microcapsules composed of bacterial polyglucuronic acid  Int J Biol Macromol  2023  244:125481  PubMed ID: 37343612   DOI: 10.1016/j.ijbiomac.2023.125481
19663  Kotani T, Mubarok W, Hananouchi T, Sakai S.  Horseradish Peroxidase-Mediated Bioprinting via Bioink Gelation by Alternately Extruded Support Material  ACS Biomater Sci Eng  2023  9(10):5804-5812  PubMed ID: 37738620   DOI: 10.1021/acsbiomaterials.3c00996
19800  Hori M, Takahashi A, Hosoda K, Ogura M, Harada-Shiba M.  A Low-Frequency APOB p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia  J Clin Endocrinol Metab  2023  108(2):422-432  PubMed ID: 36190978   DOI: 10.1210/clinem/dgac572
19810  Sekiguchi M, Fujinami Y, Takado K, Kimoto Y, Higashimura Y.  Activity difference of three labdane diterpenoids on human constitutive androstane receptor  Biosci Biotechnol Biochem  2023  87(11):1310-1315  PubMed ID: 37580155   DOI: 10.1093/bbb/zbad113
19821  Liu S, Morihiro K, Takeuchi F, Li Y, Okamoto A.  Interstrand crosslinking oligonucleotides elucidate the effect of metal ions on the methylation status of repetitive DNA elements  Front Chem  2023  11:1122474  PubMed ID: 36711237   DOI: 10.3389/fchem.2023.1122474
19846  Takagi M, Yamada M, Utoh R, Seki M.  A multiscale, vertical-flow perfusion system with integrated porous microchambers for upgrading multicellular spheroid culture  Lab Chip  2023  23(9):2257-2267  PubMed ID: 37038847   DOI: 10.1039/d3lc00168g
19919  Wuputra K, Tsai MH, Kato K, Ku CC, Pan JB, Yang YH, Saito S, Wu CC, Lin YC, Cheng KH, Kuo KK, Noguchi M, Nakamura Y, Yoshioka T, Wu DC, Lin CS, Yokoyama KK.  Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery  Inflamm Regen  2023  43(1):42  PubMed ID: 37596694   DOI: 10.1186/s41232-023-00290-6
19948  Ota K, Sakai S, Ohhata T, Suzuki T, Uchida C, Niida H, Kitagawa M.  APOBEC3B expression is promoted by lincNMR collaborating with TGF-β-Smad pathway  Carcinogenesis  2023  44(1):1-14  PubMed ID: 36335471   DOI: 10.1093/carcin/bgac086
19960  Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.  An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types  BMC Genomics  2023  24(1):735  PubMed ID: 38049715   DOI: 10.1186/s12864-023-09841-0
21073  Matsuo K, Abiko Y, Yamano S, Toriba A, Matsusue K, Kumagai Y.  Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine.  Biol Pharm Bull  2023  46(2):338-342  PubMed ID: 36724962   DOI: 10.1248/bpb.b22-00543
21074  Matsuo K, Abiko Y, Yamano S, Matsusue K, Kumagai Y.  Activation of HSP90/HSF1 Signaling as an Adaptive Response to an Electrophilic Metabolite of Morphine.  Biol Pharm Bull  2023  46(2):334-337  PubMed ID: 36724961   DOI: 10.1248/bpb.b22-00531
21276  Mubarok W, Elvitigala KCML, Kotani T, Sakai S.  Visible light photocrosslinking of sugar beet pectin for 3D bioprinting applications.  Carbohydr Polym  2023  316:121026  PubMed ID: 37321724   DOI: 10.1016/j.carbpol.2023.121026
17493  Yamazaki K, Matsuo K, Okada A, Uno N, Suzuki T, Abe S, Hamamichi S, Kishima N, Togai S, Tomizuka K, Kazuki Y.  Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery  Sci Rep  2022  12(1):21790  PubMed ID: 36526651   DOI: 10.1038/s41598-022-25959-9
17512  amamoto H, Yoshida N, Kihara S.  Esaxerenone Blocks Vascular Endothelial Inflammation Through SGK1  J Cardiovasc Pharmacol  2022  80(4):583-591  PubMed ID: 35900901   DOI: 10.1097/FJC.0000000000001316
17594  Akiyama M, Shinkai Y, Yamakawa H, Kim YG, Kumagai Y.  Potentiation of methylmercury toxicity by combined metal exposure: In vitro and in vivo models of a restricted metal exposome  Chemosphere  2022  299:134374  PubMed ID: 35318019   DOI: 10.1016/j.chemosphere.2022.134374
17669  Kamiya M, Matsumoto M, Yamashita K, Izumi T, Kawaguchi M, Mizukami S, Tsurumaru M, Mukai H, Kawakami S.  Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability  Pharmaceutics  2022  14(11):2357  PubMed ID: 36365175   DOI: 10.3390/pharmaceutics14112357
17788  Takeuchi Y, Ushimaru K, Kaneda K, Maruyama C, Ito T, Yamanaka K, Ogasawara Y, Katano H, Kato Y, Dairi T, Hamano Y.  First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria  Commun Biol  2022  5(1):1132  PubMed ID: 36289442   DOI: 10.1038/s42003-022-04110-4
19530  Hu D, Fumoto S, Miyamoto H, Tanaka M, Nishida K.  Flavonoids Enhance Lipofection Efficiency and Ameliorate Cytotoxicity in Colon26 and HepG2 Cells via Oxidative Stress Regulation  Pharmaceutics  2022  14(6):1203  PubMed ID: 35745776   DOI: 10.3390/pharmaceutics14061203
20483  Koide R, Hirane N, Kambe D, Yokoi Y, Otaki M, Nishimura SI.  Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis.  Biomaterials  2022  280:121314  PubMed ID: 34906850   DOI: 10.1016/j.biomaterials.2021.121314
16114  Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK.  Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts  Cell Biol Toxicol  2022  Mar 15  PubMed ID: 33723743   DOI: 10.1007/s10565-021-09592-2
16273  Sakai S, Kotani T, Harada R, Goto R, Morita T, Bouissil S, Dubessay P, Pierre G, Michaud P, El Boutachfaiti R, Nakahata M, Kojima M, Petit E, Delattre C.  Development of phenol-grafted polyglucuronic acid and its application to extrusion-based bioprinting inks  Carbohydr Polym  2022  277:118820  PubMed ID: 34893237   DOI: 10.1016/j.carbpol.2021.118820
20613  Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.  Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.  Analyst  2022    PubMed ID: 35297918   DOI: 10.1039/d2an00052k
20657  Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y.  Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.  Biochem Biophys Rep  2022  29:101223  PubMed ID: 35146136   DOI: 10.1016/j.bbrep.2022.101223
20752  Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.  Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.  J Toxicol Sci  2022  47(6):249-255  PubMed ID: 35650141   DOI: 10.2131/jts.47.249
20753  Luong NC, Abiko Y, Aoki H, Kumagai Y.  A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones.  Biol Pharm Bull  2022  45(6):798-802  PubMed ID: 35650106   DOI: 10.1248/bpb.b22-00080
16739  Hori K, Higashida S, Osaki T, Kawano T, Inaba H, Matsuura K, Iwasaki T.  Intracellular delivery and photothermal therapeutic effects of polyhistidine peptide-modified gold nanoparticles  J Biotechnol  2022  354:34-44  PubMed ID: 35724765   DOI: 10.1016/j.jbiotec.2022.06.006
20784  Abiko Y, Taguchi K, Hisamori M, Hiyoshi-Arai K, Luong NC, Toriba A, Kumagai Y.  Redox Homeostasis is Disturbed by Redox Cycling between Reactive Cysteines of Thioredoxin 1 and 9,10-Phenanthrenequinone, an Atmospheric Electron Acceptor.  Chem Res Toxicol  2022    PubMed ID: 35862866   DOI: 10.1021/acs.chemrestox.2c00174
16971  Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M.  Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells  Int J Mol Sci  2022  23(15):8660  PubMed ID: 35955793   DOI: 10.3390/ijms23158660
20862  Tachikawa R, Saito H, Moteki H, Kimura M, Kitagishi H, Arce F Jr, See GL, Tanikawa T, Inoue Y.  Preparation, Characterization, and In Vitro Evaluation of Inclusion Complexes Formed between S-Allylcysteine and Cyclodextrins.  ACS Omega  2022  7(35):31233-31245  PubMed ID: 36092555   DOI: 10.1021/acsomega.2c03489
20947  Ishida-Ishihara S, Takada R, Furusawa K, Ishihara S, Haga H.  Improvement of the cell viability of hepatocytes cultured in three-dimensional collagen gels using pump-free perfusion driven by water level difference.  Sci Rep  2022  12(1):20269  PubMed ID: 36434099   DOI: 10.1038/s41598-022-24423-y
17333  Inaba H, Sueki Y, Ichikawa M, Kabir AMR, Iwasaki T, Shigematsu H, Kakugo A, Sada K, Tsukazaki T, Matsuura K.  Generation of stable microtubule superstructures by binding of peptide-fused tetrameric proteins to inside and outside  Sci Adv  2022  8(36):eabq3817  PubMed ID: 36070375   DOI: 10.1126/sciadv.abq3817
20997  Kawaguchi M, Noda M, Ono A, Kamiya M, Matsumoto M, Tsurumaru M, Mizukami S, Mukai H, Kawakami S.  Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice.  J Pharm Sci  2022    PubMed ID: 36596392   DOI: 10.1016/j.xphs.2022.12.026
21019  Kazama R, Fujita S, Sakai S.  Cell Dome as an Evaluation Platform for Organized HepG2 Cells.  Cells  2022    PubMed ID: 36611862   DOI: 10.3390/cells12010069
21983  Hu X, Roy SR, Jin C, Li G, Zhang Q, Asano N, Asahina S, Kajiwara T, Takahara A, Feng B, Aoki K, Xu C, Zhang Y.  Control cell migration by engineering integrin ligand assembly.  Nat Commun  2022  13(1):5002  PubMed ID: 36008449   DOI: 10.1038/s41467-022-32686-2
13179  Hayakawa EH, Kato H, Nardone GA, Usukura J.  A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells.  Parasitol Int  2021    PubMed ID: 32853776   DOI: 10.1016/j.parint.2020.102179
13396  Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.  Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis.  Biochem Biophys Rep  2021    PubMed ID: 33392396   DOI: 10.1016/j.bbrep.2020.100882
13418  Abiko Y, Aoki H, Kumagai Y.  Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome.  Toxicol Appl Pharmacol  2021    PubMed ID: 33428920   DOI: 10.1016/j.taap.2020.115392
20024  Yamazaki T, Tokiwa T.  Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.  Hum Cell  2021    PubMed ID: 33495943   DOI: 10.1007/s13577-021-00487-2
20049  Abiko Y, Katayama Y, Akiyama M, Kumagai Y.  Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts.  Food Chem Toxicol  2021  150:112061  PubMed ID: 33587975   DOI: 10.1016/j.fct.2021.112061
20081  Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.  The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.  Oncotarget  2021  12(4):333-343  PubMed ID: 33659044   DOI: 10.18632/oncotarget.27881
20119  Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H.  Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication.  Commun Biol  2021  4(1):425  PubMed ID: 33782534   DOI: 10.1038/s42003-021-01880-1
20166  Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.  CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.  Hepatol Commun  2021  5(2):334-348  PubMed ID: 33553979   DOI: 10.1002/hep4.1643
20204  Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C.  Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells.  Monoclon Antib Immunodiagn Immunother  2021  40(3):118-123  PubMed ID: 34076498   DOI: 10.1089/mab.2020.0046
20281  Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M.  Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten.  J Food Sci Technol  2021  58(9):3504-3513  PubMed ID: 34366467   DOI: 10.1007/s13197-021-05040-5
20288  Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y.  Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.  Int J Mol Sci  2021  22(6)  PubMed ID: 33799598   DOI: 10.3390/ijms22062843
20384  Fujita I, Watanabe H, Ikegami K, Imafuku T, Ichimizu S, Chikamatsu M, Kobayashi K, Tanaka R, Yamada K, Maeda H, Maruyama T.  Involvement of the Parathyroid Hormone-Related Protein on Changes in the CYP3A Expression in Cancer Cachexia.  Mol Pharm  2021    PubMed ID: 34734526   DOI: 10.1021/acs.molpharmaceut.1c00490
20502  Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K.  PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.  Cells  2021  10(12)  PubMed ID: 34944058   DOI: 10.3390/cells10123550
16100  Ogawa S, Kubo H, Murayama Y, Kubota T, Yubakami M, Matsumoto T, Yamamoto Y, Morimura R, Ikoma H, Okamoto K, Kamiya M, Urano Y, Otsuji E.  Rapid fluorescence imaging of human hepatocellular carcinoma using the β-galactosidase-activatable fluorescence probe SPiDER-βGal  Sci Rep  2021  11(1):1794  PubMed ID: 34504174   DOI: 10.1038/s41598-021-97073-1
16205  Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T, Yoshiji H.  Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway  J Nutr Biochem  2021  89:108573  PubMed ID: 33388347   DOI: 10.1016/j.jnutbio.2020.108573
16370  Enokiya T, Nishikawa K, Hamada Y, Ikemura K, Sugimura Y, Okuda M.  Temporary decrease in tacrolimus clearance in cytochrome P450 3A5 non-expressors early after living donor kidney transplantation: Effect of interleukin 6-induced suppression of the cytochrome P450 3A gene  Basic Clin Pharmacol Toxicol   2021  128(3):525-533  PubMed ID: 33248001   DOI: 10.1111/bcpt.13539
16372  Yoshitaka Koseki, Yoshikazu Ikuta, Farsai Taemaitree, Nozomi Saito, Ryuju Suzuki, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai  Fabrication of size-controlled SN-38 pure drug nanocrystals through an ultrasound-assisted reprecipitation method toward efficient drug delivery for cancer treatment  Journal of Crystal Growth  2021  572:126265    DOI: 10.1016/j.jcrysgro.2021.126265
20621  Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.  Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.  J Toxicol Sci  2021  46(12):569-587  PubMed ID: 34853243   DOI: 10.2131/jts.46.569
22038  Taguchi T, Kodera Y, Oba K, Saito T, Nakagawa Y, Kawashima Y, Shichiri M.  Suprabasin-derived bioactive peptides identified by plasma peptidomics.  Sci Rep  2021    PubMed ID: 33441610   DOI: 10.1038/s41598-020-79353-4
19253  Wen-Ying Liu, Takuya Miyakawa, Jun Lu, Rui-Zeng Gu, Yun Hua Hsieh, Yumiko Miyauchi, Kana Katsuno, Mu-Yi Cai, Masaru Tanokura  Low-molecular-weight peptides with potential cardiovascular regulatory functions from Atlantic salmon skin  International Journal of Food Engineering  2020  16    DOI: 10.1515/ijfe-2020-0072
12030  Yoshizawa N, Sugimoto K, Tameda M, Inagaki Y, Ikejiri M, Inoue H, Usui M, Ito M, Takei Y.  miR-3940-5p/miR-8069 ratio in urine exosomes is a novel diagnostic biomarker for pancreatic ductal adenocarcinoma.  Oncol Lett  2020    PubMed ID: 32218818   DOI: 10.3892/ol.2020.11357
12057  Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.  Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver.  Biochim Biophys Acta Mol Basis Dis  2020    PubMed ID: 32088316   DOI: 10.1016/j.bbadis.2020.165731
12094  Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H.  Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet.  Tissue Eng Part C Methods  2020    PubMed ID: 32186996   DOI: 10.1089/ten.tec.2019.0330
12198  Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki   Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells  Nature Communications  2020  11:5292   PubMed ID: 33087715   DOI: 10.1038/s41467-020-19041-z
12439  Fujiyama Y, Kumamoto Y, Nishizawa N, Nakamoto S, Harada H, Yokota K, Tanaka Y, Igarashi K, Oiki H, Okuwaki K, Iwai T, Kajita S, Takahashi H, Tajima H, Kaizu T, Sasaki J, Watanabe M, Yamashita K.  Promoter DNA Hypermethylation of the Cysteine Dioxygenase 1 (CDO1) Gene in Intraductal Papillary Mucinous Neoplasm (IPMN)  Ann Surg Oncol   2020  27(10):4007-4016  PubMed ID: 32144623   DOI: 10.1245/s10434-020-08291-2
12963  Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M.  Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation.  ACS Omega  2020    PubMed ID: 32905425   DOI: 10.1021/acsomega.0c02385
13027  Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T.  Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells.  In Vitro Cell Dev Biol Anim  2020    PubMed ID: 32394241   DOI: 10.1007/s11626-020-00451-8
13036  Tanaka M, Sato A, Kishimoto Y, Mabashi-Asazuma H, Kondo K, Iida K.  Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes.  Nutrients  2020    PubMed ID: 32443660   DOI: 10.3390/nu12051479
13053  Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ.  TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells.  Cell Death Dis  2020    PubMed ID: 32471991   DOI: 10.1038/s41419-020-2618-6
13073  Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.  Free Radic Biol Med  2020    PubMed ID: 32553752   DOI: 10.1016/j.freeradbiomed.2020.06.005
13103  Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J.  Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.  NPJ Precis Oncol  2020    PubMed ID: 32656360   DOI: 10.1038/s41698-020-0125-y
13189  Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y.  A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract.  Food Chem Toxicol  2020    PubMed ID: 32871193   DOI: 10.1016/j.fct.2020.111706
13191  Xu DQ, Yuan XJ, Hirayama M, Toyoda H.  Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway.  In Vivo  2020    PubMed ID: 32871763   DOI: 10.21873/invivo.12051
13241  Yamashita R, Komaki Y, Yang G, Ibuki Y.  Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.  Mutat Res  2020    PubMed ID: 33198939   DOI: 10.1016/j.mrgentox.2020.503273
13290  Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H.  Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential.  Sci Rep  2020    PubMed ID: 33060804   DOI: 10.1038/s41598-020-74590-z
13528  Ishizawa K, Togami K, Tada H, Chono S.  Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers  J Pharm Sci   2020  109(12):3608-3616  PubMed ID: 32926888   DOI: 10.1016/j.xphs.2020.08.028
13635  Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K.  Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system  Xenobiotica  2020  50(6):654-662  PubMed ID: 31631733   DOI: 10.1080/00498254.2019.1683258
14866  Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I.  Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver  Mol Pharm  2020  17(8):2821-2830  PubMed ID: 32602343   DOI: 10.1021/acs.molpharmaceut.0c00193
5027  Nishizawa N1, Harada H1, Kumamoto Y1, Kaizu T, Katoh H, Tajima H, Ushiku H, Yokoi K, Igarashi K, Fujiyama Y, Okuwaki K, Iwai T, Watanabe M, Yamashita K1  Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer.  Cancer Sci  2019  110(9):2846-2855  PubMed ID: 31325200   DOI: 10.1111/cas.14134
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272   DOI: 10.1016/j.molcel.2019.09.009
11522  Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H.  Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.  J. Cell. Physiol.  2019    PubMed ID: 30993729   DOI: 10.1002/jcp.28625
11538  Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.  Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.  Neoplasia  2019    PubMed ID: 31042624   DOI: 10.1016/j.neo.2019.03.007
11857  Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y.  Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists.  Molecules  2019    PubMed ID: 31137814   DOI: 10.3390/molecules24102019
6837  Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S.  Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.  Anticancer Agents Med Chem  2019  19(13):1651-1657  PubMed ID: 31038081   DOI: 10.2174/1871520619666190416101622
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114   DOI: 10.3892/ol.2018.9869
9759  Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito  Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells  Fundamental Toxicological Sciences  2019  6 :281-286    DOI: 10.2131/fts.6.281
9763  Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita  Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells  Biochem Biophys Res Commun  2019  509(1):268-274  PubMed ID: 30583860   DOI: 10.1016/j.bbrc.2018.12.118
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920   DOI: 10.18433/jpps30444
11048  Yuta Kurashina, Ryo Sato, Hiroaki Onoe  Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly  APL Bioeng  2019  3(4):046101  PubMed ID: 31737859   DOI: 10.1063/1.5109966
11057  Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda  Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein  Sci Rep  2019  9(1):20359  PubMed ID: 31889141   DOI: 10.1038/s41598-019-56900-2
12238  Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond  Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy  Anal Chem  2019  91(4):2710-2718  PubMed ID: 30664349   DOI: 10.1021/acs.analchem.8b04393
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12444  Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T.  Plasmodium RON12 localizes to the rhoptry body in sporozoites  Parasitol Int  2019  68(1):17-23  PubMed ID: 30290224   DOI: 10.1016/j.parint.2018.10.001
12445  Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T.  Glass-based organ-on-a-chip device for restricting small molecular absorption  J Biosci Bioeng  2019  127(5):641-646  PubMed ID: 30473393   DOI: 10.1016/j.jbiosc.2018.10.019
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22044  Fujiyoshi J, Yamaza H, Sonoda S, Yuniartha R, Ihara K, Nonaka K, Taguchi T, Ohga S, Yamaza T.  Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.  Sci Rep  2019  9(1):1535  PubMed ID: 30733544   DOI: 10.1038/s41598-018-38275-y
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10660  Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M.  β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.  Environ Sci Pollut Res Int  2018  25:6320-6328  PubMed ID: 29247416   DOI: 10.1007/s11356-017-0977-z
10774  Yajima Y, Lee CN, Yamada M, Utoh R, Seki M.  Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers.  J. Biosci. Bioeng.  2018  126(1):111-118  PubMed ID: 29502942   DOI: 10.1016/j.jbiosc.2018.01.022
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10847  Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K.  Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.  PLoS ONE  2018  13:e0194785  PubMed ID: 29746493   DOI: 10.1371/journal.pone.0194785
11025    Isolation of activating factors of serotonin N-acetyltransferase from rice peptides  Journal of Functional Foods  2018  41, 148-154    DOI: 10.1016/j.jff.2017.12.051
11089  Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S.  Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides.  PLoS ONE  2018  13(6):e0198264  PubMed ID: 29856876   DOI: 10.1371/journal.pone.0198264
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14907  Takiguchi S, Ayaori M, Yakushiji E, Nishida T, Nakaya K, Sasaki M, Iizuka M, Uto-Kondo H, Terao Y, Yogo M, Komatsu T, Ogura M, Ikewaki K.  Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways  Arterioscler Thromb Vasc Biol  2018  38(7):1454-1467  PubMed ID: 29748333   DOI: 10.1161/ATVBAHA.118.311056
16887  Tanaka T, Hirota T, Ieiri I.  Relationship between DNA Methylation in the 5' CpG Island of the SLC47A1 (Multidrug and Toxin Extrusion Protein MATE1) Gene and Interindividual Variability in MATE1 Expression in the Human Liver  Mol Pharmacol  2018  93(1):1-7  PubMed ID: 29070695   DOI: 10.1124/mol.117.109553
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