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Cell No. : Cell Name
RCB1886 : Hep G2  update : 2021/10/08
CommentHuman cell line derived from hepatoblastoma. Secretes several products such as albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. TKG0205 (Deposited from Tohoku Univ.). Information
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0205 HepG2
Animal _human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Male
Age at sampling 15 years
Tissue liver
Disease name hepatocyte carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0205)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0027
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 137


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Reference
11987  Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles  Hep G2 is a hepatoblastoma-derived cell line  Hum Pathol  2009  40(10):1512-5  PubMed ID: 19751877
1155  Knowles, B B, Howe, C C, Aden, D P  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.  Science  1980  209:497-9  PubMed ID: 6248960
4984  Diamond L1, Kruszewski F, Aden DP, Knowles BB, Baird WM.  Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.  Carcinogenesis  1980  1(10):871-5  PubMed ID: 11219860
465  Aden, D P, Fogel A, Plotkin S, Damjanov I, Knowles, B B  Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.  Nature  1979  282:615-6  PubMed ID: 233137

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User's Publication
13179  Hayakawa EH, Kato H, Nardone GA, Usukura J.  A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells.  Parasitol Int  2021    PubMed ID: 32853776
13396  Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H, Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.  Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis.  Biochem Biophys Rep  2021    PubMed ID: 33392396
13418  Abiko Y, Aoki H, Kumagai Y.  Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome.  Toxicol Appl Pharmacol  2021    PubMed ID: 33428920
20024  Yamazaki T, Tokiwa T.  Elevated levels of expression of cytochrome P450 3A4 in a human liver epithelial cell line in differentiation-inducing conditions.  Hum Cell  2021    PubMed ID: 33495943
20049  Abiko Y, Katayama Y, Akiyama M, Kumagai Y.  Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts.  Food Chem Toxicol  2021  150:112061  PubMed ID: 33587975
20081  Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.  The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.  Oncotarget  2021  12(4):333-343  PubMed ID: 33659044
20119  Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H.  Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication.  Commun Biol  2021  4(1):425  PubMed ID: 33782534
20166  Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.  CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.  Hepatol Commun  2021  5(2):334-348  PubMed ID: 33553979
20204  Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C.  Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells.  Monoclon Antib Immunodiagn Immunother  2021  40(3):118-123  PubMed ID: 34076498
20281  Liu WY, Miyakawa T, Lu J, Hsieh YH, Gu R, Miyauchi Y, Katsuno K, Cai MY, Tanokura M.  Isolation and characterization of oligopeptides with vascular disease suppression effects derived from wheat gluten.  J Food Sci Technol  2021  58(9):3504-3513  PubMed ID: 34366467
20288  Iwado S, Abe S, Oshimura M, Kazuki Y, Nakajima Y.  Bioluminescence Measurement of Time-Dependent Dynamic Changes of CYP-Mediated Cytotoxicity in CYP-Expressing Luminescent HepG2 Cells.  Int J Mol Sci  2021  22(6)  PubMed ID: 33799598
12057  Seyama M, Yoshida K, Yoshida K, Fujiwara N, Ono K, Eguchi T, Kawai H, Guo J, Weng Y, Haoze Y, Uchibe K, Ikegame M, Sasaki A, Nagatsuka H, Okamoto K, Okamura H, Ozaki K.  Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver.  Biochim Biophys Acta Mol Basis Dis  2020    PubMed ID: 32088316
12094  Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H.  Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet.  Tissue Eng Part C Methods  2020    PubMed ID: 32186996
12198  Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito, Kenichi Horisawa, Yasuyuki Ohkawa, Shizuka Miura, Takeshi Goya, Junpei Yamamoto, Masao Nagasaki, Kazuko Ueno, Daisuke Saitou, Mikita Suyama, Yoshihiko Maehara, Wataru Kumamaru, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki   Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells  Nature Communications  2020  11:5292   PubMed ID: 33087715
12963  Saeki K, Hiramatsu H, Hori A, Hirai Y, Yamada M, Utoh R, Seki M.  Sacrificial Alginate-Assisted Microfluidic Engineering of Cell-Supportive Protein Microfibers for Hydrogel-Based Cell Encapsulation.  ACS Omega  2020    PubMed ID: 32905425
13027  Hirano T, Hirata M, Fujimoto S, Nguyen NT, Le QA, Tanihara F, Otoi T.  Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells.  In Vitro Cell Dev Biol Anim  2020    PubMed ID: 32394241
13053  Kim DH, Kim WD, Kim SK, Moon DH, Lee SJ.  TGF-β1-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells.  Cell Death Dis  2020    PubMed ID: 32471991
13073  Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.  Free Radic Biol Med  2020    PubMed ID: 32553752
13103  Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, Koh K, Hayashi Y, Kanamori Y, Kasahara M, Kohashi K, Kato M, Yoshioka T, Matsumoto K, Oka A, Taguchi T, Sanada M, Tanaka Y, Miyano S, Hata K, Ogawa S, Takita J.  Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.  NPJ Precis Oncol  2020    PubMed ID: 32656360
13189  Abiko Y, Okada M, Aoki H, Mizokawa M, Kumagai Y.  A strategy for repression of arsenic toxicity through nuclear factor E2 related factor 2 activation mediated by the (E)-2-alkenals in Coriandrum sativum L. leaf extract.  Food Chem Toxicol  2020    PubMed ID: 32871193
13191  Xu DQ, Yuan XJ, Hirayama M, Toyoda H.  Huaier Extract Induces Apoptosis in Hepatoblastoma Cells Via the MEK/ERK Signaling Pathway.  In Vivo  2020    PubMed ID: 32871763
13241  Yamashita R, Komaki Y, Yang G, Ibuki Y.  Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair.  Mutat Res  2020    PubMed ID: 33198939
13528  Ishizawa K, Togami K, Tada H, Chono S.  Multiscale Live Imaging Using Förster Resonance Energy Transfer (FRET) for Evaluating the Biological Behavior of Nanoparticles as Drug Carriers  J Pharm Sci   2020  109(12):3608-3616  PubMed ID: 32926888
13635  Taniguchi M, Miyamoto H, Tokunaga A, Fumoto S, Tanaka T, Nishida K.  Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system  Xenobiotica  2020  50(6):654-662  PubMed ID: 31631733
14866  Tajiri A, Hirota T, Kawano S, Yonamine A, Ieiri I.  Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver  Mol Pharm  2020  17(8):2821-2830  PubMed ID: 32602343
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272
11522  Li M, Cui ZG, Zakki SA, Feng Q, Sun L, Feril LB Jr, Inadera H.  Aluminum chloride causes 5-fluorouracil resistance in hepatocellular carcinoma HepG2 cells.  J. Cell. Physiol.  2019    PubMed ID: 30993729
11538  Maehara O, Ohnishi S, Asano A, Suda G, Natsuizaka M, Nakagawa K, Kobayashi M, Sakamoto N, Takeda H.  Metformin Regulates the Expression of CD133 Through the AMPK-CEBPβ Pathway in Hepatocellular Carcinoma Cell Lines.  Neoplasia  2019    PubMed ID: 31042624
11857  Utsugi Y, Kobuchi H, Kawamura Y, Atito ASA, Nagao M, Isoda H, Miyamae Y.  Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPARγ Agonists.  Molecules  2019    PubMed ID: 31137814
6837  Bouallagui Z, Mahmoudi A, Maalej A, Hadrich F, Isoda H, Sayadi S.  Contribution of Major Polyphenols to the Antioxidant Profile and Cytotoxic Activity of Olive Leaves.  Anticancer Agents Med Chem  2019  19(13):1651-1657  PubMed ID: 31038081
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114
9759  Tomoyuki Sato, Akinori Takemura, Yugo Ikeyama, Yuriko Sakamaki, Ayako Mimata, Haruyo Aoyagi, Hideki Aizaki, Shuichi Sekine, Kousei Ito  Transmission electron microscopy of the benzbromarone-induced change in mitochondrial morphology in HepG2 cells  Fundamental Toxicological Sciences  2019  6 :281-286 
9763  Kosuke Inamura, Yuji Komizu, Mami Yamakuchi, Seiichi Ishida, Yoko Matsumoto, Taku Matsushita  Inhibitory Effect of Hybrid Liposomes on the Growth of Liver Cancer Stem Cells  Biochem Biophys Res Commun  2019  509(1):268-274  PubMed ID: 30583860
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920
11048  Yuta Kurashina, Ryo Sato, Hiroaki Onoe  Microfiber-shaped building-block tissues with endothelial networks for constructing macroscopic tissue assembly  APL Bioeng  2019  3(4):046101  PubMed ID: 31737859
11057  Kenji Ikemura, Shun-Ichi Hiramatsu, Yuri Shinogi, Yusuke Nakatani, Isao Tawara, Takuya Iwamoto, Naoyuki Katayama, Masahiro Okuda  Concomitant febuxostat enhances methotrexate-induced hepatotoxicity by inhibiting breast cancer resistance protein  Sci Rep  2019  9(1):20359  PubMed ID: 31889141
12238  Ahmed Ali, Yasmine Abouleila, Yoshihiro Shimizu, Eiso Hiyama, Tomonobu M Watanabe, Toshio Yanagida, Arno Germond  Single-Cell Screening of Tamoxifen Abundance and Effect Using Mass Spectrometry and Raman-Spectroscopy  Anal Chem  2019  91(4):2710-2718  PubMed ID: 30664349
12365  Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K.  Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro  Drug Metab Pharmacokinet  2019  34(4):272-279  PubMed ID: 31280915
12443  Kojima K, Nakamura T, Ooizumi Y, Igarashi K, Tanaka T, Yokoi K, Ishii S, Nishizawa N, Katoh H, Kosaka Y, Sato T, Watanabe M, Yamashita K.  Clinical significance of cancer specific methylation of the CDO1 gene in small bowel cancer  PLoS One  2019  14(1):e0211108  PubMed ID: 30677088
12444  Oda-Yokouchi Y, Tachibana M, Iriko H, Torii M, Ishino T, Tsuboi T.  Plasmodium RON12 localizes to the rhoptry body in sporozoites  Parasitol Int  2019  68(1):17-23  PubMed ID: 30290224
12445  Hirama H, Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Kanamori T, Inoue T.  Glass-based organ-on-a-chip device for restricting small molecular absorption  J Biosci Bioeng  2019  127(5):641-646  PubMed ID: 30473393
12472  Hara M, Takeba Y, Iiri T, Ohta Y, Ootaki M, Watanabe M, Watanabe D, Koizumi S, Otsubo T, Matsumoto N.  Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway  Cancer Sci  2019  110(1):235-244  PubMed ID: 30390393
12517  Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.  Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)  Nat Prod Res  2019  33(2):189-195  PubMed ID: 29457741
10634  Hara J, Tanaka Y, Kaneko H, Itoh Y, Ikegaya H.  Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains.  Arch. Virol.  2018  163:633-637  PubMed ID: 29198036
10641  Kaji K, Nishimura N, Seki K, Sato S, Saikawa S, Nakanishi K, Furukawa M, Kawaratani H, Kitade M, Moriya K, Namisaki T, Yoshiji H.  Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake.  Int. J. Cancer  2018  142:1712-1722  PubMed ID: 29205334
10660  Darwish WS, Ikenaka Y, Nakayama S, Mizukawa H, Thompson LA, Ishizuka M.  β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line.  Environ Sci Pollut Res Int  2018  25:6320-6328  PubMed ID: 29247416
10774  Yajima Y, Lee CN, Yamada M, Utoh R, Seki M.  Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers.  J. Biosci. Bioeng.  2018  126(1):111-118  PubMed ID: 29502942
10786  He Q, Okajima T, Onoe H, Subagyo A, Sueoka K, Kuribayashi-Shigetomi K.  Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures.  Sci Rep  2018  8:4556  PubMed ID: 29540810
10847  Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K.  Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.  PLoS ONE  2018  13:e0194785  PubMed ID: 29746493
11025    Isolation of activating factors of serotonin N-acetyltransferase from rice peptides  Journal of Functional Foods  2018  41, 148-154 
11089  Yamamiya D, Mizukoshi E, Kaji K, Terashima T, Kitahara M, Yamashita T, Arai K, Fushimi K, Honda M, Kaneko S.  Immune responses of human T lymphocytes to novel hepatitis B virus-derived peptides.  PLoS ONE  2018  13(6):e0198264  PubMed ID: 29856876
11139  Saikawa S, Kaji K, Nishimura N, Seki K, Sato S, Nakanishi K, Kitagawa K, Kawaratani H, Kitade M, Moriya K, Namisaki T, Mitoro A, Yoshiji H.  Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein.  Cancer Lett.  2018  434:120-129  PubMed ID: 30031758
11113  Kawai T, Ota N, Imasato A, Shirasaki Y, Otsuka K, Tanaka Y.  Profiling of N-linked glycans from 100 cells by capillary electrophoresis with large-volume dual preconcentration by isotachophoresis and stacking.  J Chromatogr A  2018  1565:138-144  PubMed ID: 29945790
11160  Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O.  In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana.  J Evid Based Integr Med  2018    PubMed ID: 30088418
11292  Hori T, Kurosawa O.  A Three-dimensional Cell Culture Method with a Micromesh Sheet and Its Application to Hepatic Cells.  Tissue Eng Part C Methods  2018    PubMed ID: 30412042
4452  Phoebe Trio1, Atsuyoshi Kawahara, Satoru Fujisaki, De-Xing Hou  Comparative Gene Expression Profiling in Cultured Cell Lines after Treatment with Wasabi-derived Isothiocyanates  KIMIKA  2018  29, 1-10 
4224  Sultana H, Watanabe K, Rana MM, Takashima R, Ohashi A, Komai M, Shirakawa H.  Effects of Vitamin K₂ on the Expression of Genes Involved in Bile Acid Synthesis and Glucose Homeostasis in Mice with Humanized PXR.  Nutrients  2018    PubMed ID: 30060524
4225  Takashima Y, Horisawa K, Udono M, Ohkawa Y, Suzuki A.  Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors.  Cancer Sci.  2018    PubMed ID: 30220099
4483  Anusornvongchai T, Nangaku M, Jao TM, Wu CH, Ishimoto Y, Maekawa H, Tanaka T, Shimizu A, Yamamoto M, Suzuki N, Sassa R, Inagi R.  Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response.  Kidney Int.  2018  94(3):536-550  PubMed ID: 29887316
4484  Wang S, Fumoto S, Miyamoto H, Tanaka M, Nishida K.  Edaravone, a cytoprotective drug, enhances transgene expression mediated by lipoplexes in HepG2 cells and mice.  Int J Pharm  2018  548(1):173-181  PubMed ID: 29969708
14907  Takiguchi S, Ayaori M, Yakushiji E, Nishida T, Nakaya K, Sasaki M, Iizuka M, Uto-Kondo H, Terao Y, Yogo M, Komatsu T, Ogura M, Ikewaki K.  Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways  Arterioscler Thromb Vasc Biol  2018  38(7):1454-1467  PubMed ID: 29748333
9988  Li S, Gao A, Dong S, Chen Y, Sun S, Lei Z, Zhang Z.  Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta.  Int. J. Biol. Macromol.  2017  96:26-34  PubMed ID: 27939510
10080  Wakuri S, Yamakage K, Kazuki Y, Kazuki K, Oshimura M, Aburatani S, Yasunaga M, Nakajima Y.  Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase.  Anal. Biochem.  2017  522:18-29  PubMed ID: 28111305
10167  Takahashi K, Suzuki N, Ogra Y.  Bioavailability Comparison of Nine Bioselenocompounds In Vitro and In Vivo.  Int J Mol Sci  2017  18:  PubMed ID: 28245633
10236  Sudo K, Niikura K, Iwaki K, Kohyama S, Fujiwara K, Doi N.  Human-derived fusogenic peptides for the intracellular delivery of proteins.  J Control Release  2017  255:1-11  PubMed ID: 28385674
10351  Nakashima KI, Ogiwara T, Hirai T, Tanaka T, Murata H, Kaburagi K, Fujii-Kuriyama Y, Hayashi H, Inoue M.  Gerontoxanthone B from Maclura cochinchinensis var. gerontogea exhibits anti-inflammatory potential as an aryl hydrocarbon receptor agonist.  Bioorg. Med. Chem.  2017  25:4253-4258  PubMed ID: 28662965
10392  Ono Y, Tomimori N, Hori H, Kitagawa Y, Shibata H.  Mechanisms of chromosomal aberrations induced by sesamin metabolites in Chinese hamster lung cells.  Mutat. Res.  2017  822:19-26  PubMed ID: 28844238
10435  Tung NH, Uto T, Hai NT, Li G, Shoyama Y.  Quassinoids from the Root of Eurycoma longifolia and Their Antiproliferative Activity on Human Cancer Cell Lines.  Pharmacogn Mag  2017  13:459-462  PubMed ID: 28839372
10446  Chen Z, Wu Y, Ma YS, Kobayashi Y, Zhao YY, Miura Y, Chiba H, Hui SP.  Profiling of cardiolipins and their hydroperoxides in HepG2 cells by LC/MS.  Anal Bioanal Chem  2017  409:5735-5745  PubMed ID: 28762068
10466  Machihara K, Tanaka H, Hayashi Y, Murakami I, Namba T.  Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78.  Biochem. Biophys. Res. Commun.  2017  492:33-40  PubMed ID: 28811106
10470  Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K, Sawashita J.  Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.  Sci Rep  2017  7:8253  PubMed ID: 28811612
10478  Fukushima T, Hara-Yamamura H, Nakashima K, Tan LC, Okabe S.  Multiple-endpoints gene alteration-based (MEGA) assay: A toxicogenomics approach for water quality assessment of wastewater effluents.  Chemosphere  2017  188:312-319  PubMed ID: 28888119
10488  Oda Y, Hidaka M, Suzuki A.  Caffeine Has a Synergistic Anticancer Effect with Cisplatin via Inhibiting Fanconi Anemia Group D2 Protein Monoubiquitination in Hepatocellular Carcinoma Cells.  Biol. Pharm. Bull.  2017  40:2005-2009  PubMed ID: 28855448
10490  Takano M, Kamei H, Nagahiro M, Kawami M, Yumoto R.  Nicotine transport in lung and non-lung epithelial cells.  Life Sci.  2017  188:76-82  PubMed ID: 28866099
10491  Inoue C, Zhao C, Tsuduki Y, Udono M, Wang L, Nomura M, Katakura Y.  SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.  NPJ Aging Mech Dis  2017  3:11  PubMed ID: 28868154
10494  Toda M, Totoki T, Nakamura C, Yasuma T, D' Alessandro-Gabazza CN, Mifuji-Moroka R, Nishihama K, Iwasa M, Horiki N, Gabazza EC, Takei Y.  Low dose of alcohol attenuates pro-atherosclerotic activity of thrombin.  Atherosclerosis  2017  265:215-224  PubMed ID: 28923781
10495  Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.  Sake lees hydrolysate protects against acetaminophen-induced hepatotoxicity via activation of the Nrf2 antioxidant pathway.  J Clin Biochem Nutr  2017  61:203-209  PubMed ID: 29203962
10519  Zhou Y, Fukuda T, Hang Q, Hou S, Isaji T, Kameyama A, Gu J.  Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation.  Sci Rep  2017  7:11563  PubMed ID: 28912543
10531  Oura K, Tadokoro T, Fujihara S, Morishita A, Chiyo T, Samukawa E, Yamana Y, Fujita K, Sakamoto T, Nomura T, Yoneyama H, Kobara H, Mori H, Iwama H, Okano K, Suzuki Y, Masaki T.  Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest.  Oncol. Rep.  2017  38:2825-2835  PubMed ID: 29048654
10552  Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.  Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.  Am. J. Chin. Med.  2017  45:1497-1511  PubMed ID: 29025293
10622  Igarashi K, Yamashita K, Katoh H, Kojima K, Ooizumi Y, Nishizawa N, Nishiyama R, Kawamata H, Tajima H, Kaizu T, Kumamoto Y, Watanabe M.  Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease.  PLoS ONE  2017  12:e0188178  PubMed ID: 29161283
10936    Cell Sheet Fabrication Using RGD Peptide-Coupled Alginate Hydrogels Fabricated by an Electrodeposition Method  Chem. Lett.  2017  46, 605–608 
10959    Induction of Drug Resistance in Human Hepatoma Cells Cultured on a Silicate Fiber-Based 3D Scaffold  Adv Biochem Biotechnol  2017  112 
10975    Collagen Microparticle-mediated 3D Cell Organization: A Facile Route to Bottom-Up Engineering of Thick and Porous Tissues  ACS Biomater. Sci. Eng.  2017  3, 2144–2154 
10990    CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element  Fundamental Toxicological Sciences  2017  4, 229-239 
9497  Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita  A New Sarasinoside Congener, Sarasinoside M 2, From a Marine Sponge Collected in the Solomon Islands  Biosci Biotechnol Biochem  2017  81(2):222-225  PubMed ID: 27760495
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625
12319  Yoshihiko Kihara, Riho Maeda, Azusa Imaizumi, Tsukasa Ichikawa, Nobukatsu Nemoto, Tsutomu Ishihara, Nobutaka Hirano, and Mitsuru Haruki  Alkyne-Functionalized Cationic Polysiloxane Polymers Conjugated with Targeting Molecules by Click Reactions for DNA Delivery  Journal of Nanoscience and Nanotechnology  2017  17/7:5081-5089 
14218  Uchiyama T, Ota H, Itaya-Hironaka A, Shobatake R, Yamauchi A, Sakuramoto-Tsuchida S, Makino M, Kimura H, Takeda M, Ohbayashi C, Takasawa S.  Up-regulation of selenoprotein P and HIP/PAP mRNAs in hepatocytes by intermittent hypoxia via down-regulation of miR-203  Biochem Biophys Rep  2017  11:130-137.  PubMed ID: 28955777
14233  Trio PZ, Kawahara A, Tanigawa S, Sakao K, Hou DX.  DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells  Nutr Cancer  2017  69(1):105-116  PubMed ID: 27911093
14234  Kudou M, Shiozaki A, Kosuga T, Shimizu H, Ichikawa D, Konishi H, Morimura R, Komatsu S, Ikoma H, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.  Heat shock exerts anticancer effects on liver cancer via autophagic degradation of aquaporin 5  Int J Oncol  2017  50(5):1857-1867  PubMed ID: 28358429
14435  Sasaki T, Sato Y, Kumagai T, Yoshinari K, Nagata K.  Effect of health foods on cytochrome P450-mediated drug metabolism  J Pharm Health Care Sci  2017  3:14  PubMed ID: 28496987
14563  Peng J, Fumoto S, Miyamoto H, Chen Y, Kuroda N, Nishida K.  One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin  J Drug Target  2017  25(8):704-714  PubMed ID: 28368667
14725  Minegishi S, Yumura A, Miyoshi H, Negi S, Taketani S, Motterlini R, Foresti R, Kano K, Kitagishi H.  Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-Permeable Hemoprotein Model Complexes  J Am Chem Soc  2017  139(16):5984-5991  PubMed ID: 28388069
7067  Yamada K, Mito F, Matsuoka Y, Ide S, Shikimachi K, Fujiki A, Kusakabe D, Ishida Y, Enoki M, Tada A, Ariyoshi M, Yamasaki T, Yamato M.  Fluorescence probes to detect lipid-derived radicals.  Nat. Chem. Biol.  2016  12:608-13  PubMed ID: 27294322
7092  M Khanmohammadi, S Sakai, T Ashida, M Taya  Production of hyaluronic-acid-based cell-enclosing microparticles and microcapsules via enzymatic reaction using a microfluidic system.  J Applied Polymer Science  2016  133:43107 
7125  Darwish WS, Ikenaka Y, Nakayama SM, Mizukawa H, Ishizuka M.  Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells.  J. Food Sci.  2016  81:T275-81  PubMed ID: 26630500
7270  Takei T, Kitazono Z, Ozuno Y, Yoshinaga T, Nishimata H, Yoshida M.  Vascular-like network prepared using hollow hydrogel microfibers.  J. Biosci. Bioeng.  2016  121:336-40  PubMed ID: 26199226
7476  Yanagida A, Nakauchi H, Kamiya A.  Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells.  Methods Mol. Biol.  2016  1357:295-310  PubMed ID: 25697415
9536  Kumagai T, Aratsu Y, Sugawara R, Sasaki T, Miyairi S, Nagata K.  Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor.  Drug Metab. Pharmacokinet.  2016  31:139-45  PubMed ID: 26987505
9642  Darwish AG, Samy MN, Sugimoto S, Otsuka H, Abdel-Salam H, Matsunami K.  Effects of Hepatoprotective Compounds from the Leaves of Lumnitzera racemosa on Acetaminophen-Induced Liver Damage in Vitro.  Chem. Pharm. Bull.  2016  64:360-5  PubMed ID: 27039833
9701  Zaitsu Y, Iwatake M, Sato K, Tsukuba T.  Lipid droplets affect elimination of Porphyromonas gingivalis in HepG2 cells by altering the autophagy-lysosome system.  Microbes Infect.  2016  18:565-71  PubMed ID: 27237960
9717  Miyamae Y, Nishito Y, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, Nagao M.  Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line.  Biochem. Biophys. Res. Commun.  2016  477:40-6  PubMed ID: 27270032
9786  Sakai S, Nomura K, Mochizuki K, Taya M.  Anchoring PEG-oleate to cell membranes stimulates reactive oxygen species production.  Colloids Surf B Biointerfaces  2016  147:336-342  PubMed ID: 27544656
9812  Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K.  Molecular hydrogen suppresses activated Wnt/β-catenin signaling.  Sci Rep  2016  6:31986  PubMed ID: 27558955
9841  Burdeos GC, Ito J, Eitsuka T, Nakagawa K, Kimura F, Miyazawa T.  δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling.  Food Funct  2016  7:4170-4174  PubMed ID: 27713963
9990  Tanaka Y, Tateishi K, Nakatsuka T, Kudo Y, Takahashi R, Miyabayashi K, Yamamoto K, Asaoka Y, Ijichi H, Tateishi R, Shibahara J, Fukayama M, Ishizawa T, Hasegawa K, Kokudo N, Koike K.  Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression.  Oncogenesis  2016  5:e277  PubMed ID: 27941932
10930    Bioactive Compounds from the Leaves of Lumnitzera racemosa against Acetaminophen-induced Liver damage in vitro  Journal of Arid Land Studies  2016  26, 179 - 182 
6039  Badr H, Kozai D, Sakaguchi R, Numata T, Mori Y.  Different Contribution of Redox-Sensitive Transient Receptor Potential Channels to Acetaminophen-Induced Death of Human Hepatoma Cell Line.  Front Pharmacol  2016  7:19  PubMed ID: 26903865
12288  Kung-Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying-Chu Lin, Ming-Ho Tsai, Kenly Wuputra, Yen-Liang Lee, Chia-Chen Ku, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Chun-Chieh Wu, Chee-Yin Chai, Richard Eckner, Chen-Lung Steve Lin, Sophie S-W Wang, Deng-Chyang Wu, Chang-Shen Lin, Kazunari K Yokoyama  Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer  Stem Cells  2016  34(11):2613-2624  PubMed ID: 27341307
12644  Minatani N, Waraya M, Yamashita K, Kikuchi M, Ushiku H, Kojo K, Ema A, Nishimiya H, Kosaka Y, Katoh H, Sengoku N, Tanino H, Sidransky D, Watanabe M.  Prognostic Significance of Promoter DNA Hypermethylation of cysteine dioxygenase 1 (CDO1) Gene in Primary Breast Cancer  PLoS One  2016  11(1):e0144862  PubMed ID: 26785325
12854  Kawauchi S, Nakamura T, Horibe S, Tanahashi T, Mizuno S, Hamaguchi T, Rikitake Y.  Down-regulation of hepatic CYP3A1 expression in a rat model of indomethacin-induced small intestinal ulcers  Biopharm Drug Dispos  2016  37(9):522-532  PubMed ID: 27666336
13986  Liu Y, Sakai S, Taya M.  Engineering tissues with a perfusable vessel-like network using endothelialized alginate hydrogel fiber and spheroid-enclosing microcapsules  Heliyon   2016  2(2):e00067  PubMed ID: 27441246
14088  Yoshitaka Koseki, Yoshikazu Ikuta, Takaaki Kamishima, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai  Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of Nano-Prodrug  Bulletin of the Chemical Society of Japan  2016  89:540–545 
14136  Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.  Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma  Cancer Res  2016  76(11):3265-76  PubMed ID: 27197151
14152  Kazuya Furusawa, Masayuki Tsuchida  Study on the effects of the hierarchical structures of collagen gels on the morphologies of engineered liver cancer tissues  2016 International Symposium on Micro-NanoMechatronics and Human Science (MHS)  2016   
14165  Kitagishi H, Minegishi S, Yumura A, Negi S, Taketani S, Amagase Y, Mizukawa Y, Urushidani T, Sugiura Y, Kano K.  Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood  J Am Chem Soc  2016  138(16):5417-25  PubMed ID: 27057920
7128  Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.  Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.  J Pharm Pharm Sci  2015  18:316-27  PubMed ID: 26626238
7219  Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T.  In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.  Stem Cell Res Ther  2015  6:171  PubMed ID: 26358689
7238  Ozeki M, Salah A, Aini W, Tamaki K, Haga H, Miyagawa-Hayashino A.  Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection.  PLoS ONE  2015  10:e0136381  PubMed ID: 26305096
7257  Anan Y, Kimura M, Hayashi M, Koike R, Ogra Y.  Detoxification of selenite to form selenocyanate in mammalian cells.  Chem. Res. Toxicol.  2015  28:1803-14  PubMed ID: 26243445
7278  Yamaori S, Kinugasa Y, Jiang R, Takeda S, Yamamoto I, Watanabe K.  Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells.  Life Sci.  2015  136:87-93  PubMed ID: 26187180
7324  Somiya M, Yamaguchi K, Liu Q, Niimi T, Maturana AD, Iijima M, Yoshimoto N, Kuroda S.  One-step scalable preparation method for non-cationic liposomes with high siRNA content.  Int J Pharm  2015  490:316-23  PubMed ID: 26027493
7474  Suzuki Y, Nakagawa K, Kato S, Tatewaki N, Mizuochi S, Ito J, Eitsuka T, Nishida H, Miyazawa T.  Metabolism and cytotoxic effects of phosphatidylcholine hydroperoxide in human hepatoma HepG2 cells.  Biochem. Biophys. Res. Commun.  2015  458:920-7  PubMed ID: 25704087
7553  Priscilla Boccia, Claudia Meconi, Elena Sturchio, Salvatore Margiotta, Pietro Ragone, Vito Summa  Natural geochemical risk in the Pollino Massif: a case-study of chromium.  Frontiers in Genetics  2015  6: 
7568  Tung NH, Uto T, Morinaga O, Shoyama Y  Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.  Natural Product Sciences  2015  21:71-75 
10187  Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka  Mutagenicity of Modelled-Heat-Treated Meat Extracts: Mutagenicity Assay, Analysis and Mechanism of Mutagenesis  Jpn J Vet Res  2015  63(4):173-82  PubMed ID: 26753243
14962  Kazuya Furusawa, Masayuki Tsuchida, Saki Yahata  Construction of engineered liver cancer tissues with multichannel collagen gel  2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)  2015  2015-11 
15144  Kawase A, Hata S, Takagi M, Iwaki M.  Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption  J Pharm Pharm Sci  2015  18(5):765-7  PubMed ID: 26670369
15145  Mira A, Shimizu K.  In vitro Cytotoxic Activities and Molecular Mechanisms of Angelica shikokiana Extract and its Isolated Compounds  Pharmacogn Mag  2015  11(Suppl 4):S564-9  PubMed ID: 27013795
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144
15195  Ohtera A, Miyamae Y, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M.  Identification of a New Type of Covalent PPARγ Agonist using a Ligand-Linking Strategy  ACS Chem Biol  2015  10(12):2794-804  PubMed ID: 26414848
12539  Kawano Y, Nagata M, Kohno T, Ichimiya A, Iwakiri T, Okumura M, Arimori K.  Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells  Biol Pharm Bull  2012  35(3):400-7  PubMed ID: 22382328
12730  Ohno M, Ikenaka Y, Ishizuka M.  All-trans retinoic acid inhibits the recruitment of ARNT to DNA, resulting in the decrease of CYP1A1 mRNA expression in HepG2 cells  Biochem Biophys Res Commun  2012  417(1):484-9  PubMed ID: 22177959
12473  Sone Y, Ueta E, Sannomaru Y, Miyake N, Sone H, Otsuka Y, Kondo K, Kurata T, Suzuki E.  Dose of 3-methylcholanthrene enhances vitamin C accumulation and mRNA expression of its transporter in the liver of ODS rats and in HepG2 cells  J Biochem Mol Toxicol  2011  25(6):369-76  PubMed ID: 21800402
10985    Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive  Dokkyo Journal of Medical Sciences  2003  30(2):131-139 
9996  Arnal JF, Battle T, Rasetti C, Challah M, Costerousse O, Vicaut E, Michel JB, Alhenc-Gelas F.  ACE in three tunicae of rat aorta: expression in smooth muscle and effect of renovascular hypertension.  Am. J. Physiol.  1994  267:H1777-84  PubMed ID: 7977808



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