Cell No. : Cell Name RCB1871 : TL-1  update : 2024/01/17
Comment			Human lymphoid cell line derived from Burkitt's lymphoma. Tumorigenic in nude mouse. TKG0607 (Deposited from Tohoku Univ.). Application consideration
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	Obinata, Masuo
		Originator	Hayashi, Yutaka (Tohoku University)
		Year of deposit	2004
		Original cell	TKG0607
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Tissue	ileocecal lymph node meta
		Classification	cancer
		History	Cell Resource Center for Biomedical Research, Tohoku University（TKG0607）
		Lifespan	infinite
		Morphology	other
		Cellosaurus(Expasy)	CVCL_B371
			deposit info	lot info
		Medium	Medium List
		Culture type		Suspension cells
		Culture method		浮遊細胞の培養に関する一般的な注意(Japanese)
		Culture medium		RPMI1640 + 10% FBS
		Antibiotics		Free
		Passage method		dilution
	Culture information	Passage ratio		1 : 4 split
		SC frequency		Subculture : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma/Acholeplasma		(-)
		Virus (HIV)		LT 400
		Virus (HTLV-1)		(-)
		Isozyme		LD, NP
		Chromosome mode		47-49(50) : 47(11),48(38),49(1)
		STR(human)		OK
Reference information		Reference	2
		User's Publication	5

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Reference

5005  Yaoita S1, Ohoi R, Hayashi Y, Watanabe T.  Establishment and characterization of TL-1 cell line from a ileo-cecal Burkitt's lymphoma  Hum Cell  1989  2(2):197  PubMed ID: 2486610

2710  Hayashi Y, Matsumura Y, Nishihira T, Watanabe I, Ohi R, Kasai M, Kumagai K, Kamada N  Burkitt's lymphoma cell line bearing surface IgA and negative for nuclear antigen of Epstein-Barr virus (EBNA).  Jpn J Exp Med  1980  50:423-34  PubMed ID: 6268866

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User's Publication

16945  Yano H, Fujiwara Y, Horlad H, Pan C, Kai K, Niino D, Ohsawa K, Higashi M, Nosaka K, Okuno Y, Tamaru JI, Mukasa A, Matsuoka M, Komohara Y.  Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy  Cancer Sci  2022  113(6):2129-2143  PubMed ID: 35343027   DOI: 10.1111/cas.15349

13099  Fujimoto K, Shinojima N, Hayashi M, Nakano T, Ichimura K, Mukasa A.  Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma.  Neurooncol Adv  2020    PubMed ID: 32793886   DOI: 10.1093/noajnl/vdaa084

11858  Shinojima N, Fujimoto K, Makino K, Todaka K, Yamada K, Mikami Y, Oda K, Nakamura K, Jono H, Kuratsu JI, Nakamura H, Yano S, Mukasa A.  Clinical significance of polyglutamylation in primary central nervous system lymphoma.  Acta Neuropathol Commun  2018    PubMed ID: 29475458   DOI: 10.1186/s40478-018-0522-4

10269  Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.  Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages  J Clin Exp Hematop  2017  57:15-20  PubMed ID: 28420814   DOI: 10.3960/jslrt.17003

13994  Horlad H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, Endo S, Kikukawa Y, Okuno Y, Matsuoka M, Takeya M, Komohara Y.  An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma  Cancer Sci  2016  107(11):1696-1704  PubMed ID: 27564404   DOI: 10.1111/cas.13065