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Cell No. : Cell Name
RCB1871 : TL-1  update : 2024/01/17
CommentHuman lymphoid cell line derived from Burkitt's lymphoma. Tumorigenic in nude mouse. TKG0607 (Deposited from Tohoku Univ.). Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Obinata, Masuo
Originator Hayashi, Yutaka (Tohoku University)
Year of deposit 2004
Original cell TKG0607
Animal _human < Mammals
Genus Homo
Species sapiens
Tissue ileocecal lymph node meta
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0607)
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_B371
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Culture method
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) LT 400
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 47-49(50) : 47(11),48(38),49(1)
STR(human) OK
Reference information Reference 2
User's Publication 5

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5005  Yaoita S1, Ohoi R, Hayashi Y, Watanabe T.  Establishment and characterization of TL-1 cell line from a ileo-cecal Burkitt's lymphoma  Hum Cell  1989  2(2):197  PubMed ID: 2486610  
2710  Hayashi Y, Matsumura Y, Nishihira T, Watanabe I, Ohi R, Kasai M, Kumagai K, Kamada N  Burkitt's lymphoma cell line bearing surface IgA and negative for nuclear antigen of Epstein-Barr virus (EBNA).  Jpn J Exp Med  1980  50:423-34  PubMed ID: 6268866  

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User's Publication
16945  Yano H, Fujiwara Y, Horlad H, Pan C, Kai K, Niino D, Ohsawa K, Higashi M, Nosaka K, Okuno Y, Tamaru JI, Mukasa A, Matsuoka M, Komohara Y.  Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy  Cancer Sci  2022  113(6):2129-2143  PubMed ID: 35343027   DOI: 10.1111/cas.15349
13099  Fujimoto K, Shinojima N, Hayashi M, Nakano T, Ichimura K, Mukasa A.  Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma.  Neurooncol Adv  2020    PubMed ID: 32793886   DOI: 10.1093/noajnl/vdaa084
11858  Shinojima N, Fujimoto K, Makino K, Todaka K, Yamada K, Mikami Y, Oda K, Nakamura K, Jono H, Kuratsu JI, Nakamura H, Yano S, Mukasa A.  Clinical significance of polyglutamylation in primary central nervous system lymphoma.  Acta Neuropathol Commun  2018    PubMed ID: 29475458   DOI: 10.1186/s40478-018-0522-4
10269  Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.  Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages  J Clin Exp Hematop  2017  57:15-20  PubMed ID: 28420814   DOI: 10.3960/jslrt.17003
13994  Horlad H, Ma C, Yano H, Pan C, Ohnishi K, Fujiwara Y, Endo S, Kikukawa Y, Okuno Y, Matsuoka M, Takeya M, Komohara Y.  An IL-27/Stat3 axis induces expression of programmed cell death 1 ligands (PD-L1/2) on infiltrating macrophages in lymphoma  Cancer Sci  2016  107(11):1696-1704  PubMed ID: 27564404   DOI: 10.1111/cas.13065

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