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Cell No. : Cell Name
RCB1773 : Lu-143  update : 2024/01/17
CommentHuman cell line derived from lung cancer. Small cell carcinoma. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Terasaki, Takeo
Originator Terasaki, Takeo
Year of deposit 2001
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 60 years
Tissue lung
Disease name Terasaki, Takeo
Metastatic ability Yes
Metastatic tissue lymph node
Classification cancer
Year of origin 1987
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_3348
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 6
User's Publication 3


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Reference
870  Yokoi S, Yasui K, Saito-Ohara F, Koshikawa K, Iizasa T, Fujisawa T, Terasaki T, Horii A, Takahashi T, Hirohashi S, Inazawa J.  A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers  Am J Pathol  2002  161(1):207-16  PubMed ID: 12107105   DOI: 10.1016/S0002-9440(10)64172-7
1974  Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K  Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.  Jpn J Cancer Res (--> Cancer Sci)  1994  85:718-22  PubMed ID: 8071114   DOI: 10.1111/j.1349-7006.1994.tb02420.x
3143  Sameshima Y, Matsuno Y, Hirohashi S, Shimosato Y, Mizoguchi H, Sugimura T, Terada M, Yokota J  Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.  Oncogene  1992  7:451-7  PubMed ID: 1312700  
3147  Miller, C W, Simon K, Aslo A, Kok K, Yokota J, Buys, C H, Terada M, Koeffler, H P  p53 mutations in human lung tumors.  Cancer Res  1992  52:1695-8  PubMed ID: 1312896  
3146  Sameshima Y, Akiyama T, Mori N, Mizoguchi H, Toyoshima K, Sugimura T, Terada M, Yokota J  Point mutation of the p53 gene resulting in splicing inhibition in small cell lung carcinoma.  Biochem Biophys Res Commun  1990  173:697-703  PubMed ID: 2175605   DOI: 10.1016/s0006-291x(05)80091-9
1111  Yokota J, Akiyama T, Fung, Y K, Benedict, W F, Namba Y, Hanaoka M, Wada M, Terasaki T, Shimosato Y, Sugimura T, et al.  Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.  Oncogene  1988  3:471-5  PubMed ID: 2856251  

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User's Publication
21515  Tabata S, Umemura S, Narita M, Udagawa H, Ishikawa T, Tsuboi M, Goto K, Ishii G, Tsuchihara K, Ochiai A, Kobayashi SS, Soga T, Makinoshima H.  Metabolic hallmarks for purine nucleotide biosynthesis in small-cell lung carcinoma.  Mol Cancer Res  2023    PubMed ID: 37773022   DOI: 10.1158/1541-7786.MCR-23-0386
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781   DOI: 10.1016/j.ccell.2018.02.004
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x



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