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21548
Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.
An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.
J Pharmacol Sci
2024
154(1):37-46
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Katoh M, Fujii T, Tabuchi Y, Shimizu T, Sakai H.
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.
J Physiol Sci
2024
74(1):23
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Negoro R, Ouchi A, Deguchi S, Takayama K, Fujita T.
Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.
Biol Pharm Bull
2024
47(8):1422-1428
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22004
Urakawa D, Shioiridani Y, Igata S, Hou DX, Sakao K.
Comparative Analysis of Acetylated Flavonoids' Chemopreventive Effects in Different Cancer Cell Lines
Int J Mol Sci
2024
25(14):7689.
PubMed ID: 39062932
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22095
Toma T, Miyakawa N, Arakaki Y, Watanabe T, Nakahara R, Ali TFS, Biswas T, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.
An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models.
Diabetologia
2024
67(11):2568-2584
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19558
Kurawaka M, Sasaki N, Yamazaki Y, Shimura F.
Near-Physiological Concentrations of Extracellular Pyruvate Stimulated Glucose Utilization along with Triglyceride Accumulation and Mitochondrial Activity in HepG2 Cells
J Nutr Sci Vitaminol (Tokyo)
2023
69(5):314-325
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19640
Sakao K, Saruwatari H, Minami S, Hou DX.
Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells
Int J Mol Sci
2023
24(23):16652
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19644
Nakamura M, Urakawa D, He Z, Akagi I, Hou DX, Sakao K.
Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II)
Int J Mol Sci
2023
24(24):17457
PubMed ID: 38139286
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19989
Kodama S, Matsumoto S, Takamura Y, Fujihara M, Watanabe M, Ono A, Kakuta H.
Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha
Toxicol Lett
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Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.
Lysine long-chain fatty acylation regulates the TEAD transcription factor.
Cell Rep
2023
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Nagatomo A, Kohno M, Kawakami H, Manse Y, Morikawa T.
Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver.
J Nat Med
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Shizu R, Otsuka Y, Ishii C, Ezaki K, Yoshinari K.
PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers.
Int J Mol Sci
2023
24(4)
PubMed ID: 36835365
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Matsumura M, Murakami M, Funaba M.
Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family
Cell Biochem Funct
2022
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Okumura M, Iwakiri T, Yoshikawa N, Nagatomo T, Ayabe T, Tsuneyoshi I, Ikeda R.
Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells
Int J Mol Sci
2022
23(16):9108
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Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.
Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.
Int J Oncol
2022
60(1)
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Takezawa T, Uzu M.
HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.
J Toxicol Sci
2022
47(1):39-50
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Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
J Nat Med
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PubMed ID: 35292883
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Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.
Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.
Oncol Rep
2022
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Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.
A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.
Nat Commun
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Kitano H, Kawabe Y, Kamihira M.
HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions
Cells
2022
11(7):1194
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Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.
Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System
Cells
2022
11(10):1677
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Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.
Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.
J Toxicol Sci
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47(6):249-255
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Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.
Nat Commun
2022
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PubMed ID: 35906200
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Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.
Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.
Sci Rep
2022
12(1):14520
PubMed ID: 36008442
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Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.
Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.
J Oral Microbiol
2022
14(1):2105013
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Imanishi S, Nagata S, Fujita T, Fujii H.
Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.
Int J Exp Pathol
2022
PubMed ID: 36153641
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Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biol
2022
57:102514
PubMed ID: 36279630
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Nagatomo A, Ninomiya K, Marumoto S, Sakai C, Watanabe S, Ishikawa W, Manse Y, Kikuchi T, Yamada T, Tanaka R, Muraoka O, Morikawa T.
A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells.
Int J Mol Sci
2022
23(21)
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Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.
J Biomater Sci Polym Ed
2021
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SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor
Drug Metabolism and Pharmacokinetics
2021
PubMed ID: 33515843
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Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.
Pharmaceutics
2021
13(1)
PubMed ID: 33430003
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Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.
Glycoconj J
2021
38(1):45-54
PubMed ID: 33523362
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Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.
Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.
J Biochem
2021
PubMed ID: 33844018
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El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.
Ann Surg Oncol
2021
PubMed ID: 33886022
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Toshiaki TAKEZAWA
Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes
Nano Biomedicine
2021
13:1-7
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Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.
A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment
Cancers (Basel)
2021
13(16):3997
PubMed ID: 34439154
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Endo A, Asayama S.
Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization
Pharmaceutics
2021
13(12):2084
PubMed ID: 34959365
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16135
Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.
A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals
Free Radic Biol Med
2021
163:297-305
PubMed ID: 33359688
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Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.
J Toxicol Sci
2021
46(12):569-587
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Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.
Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach
Tumour Biol
2021
43(1):309-325
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Takemura A, Gong S, Sato T, Kawaguchi M, Sekine S, Kazuki Y, Horie T, Ito K.
Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells
J Pharm Sci
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110(9):3306-3312
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Kawase A, Hirosoko M, Sugihara Y, Koyama Y, Fukae A, Shimada H, Iwaki M.
NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells
Pharmaceuticals (Basel)
2021
14(3):239.
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Tsuji T, Morita SY, Nakamura Y, Ikeda Y, Kambe T, Terada T.
Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth.
Sci Rep
2021
11(1):2731
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Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto
Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation
Journal of Molecular Liquids
2020
299:112166
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Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.
Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.
Sci Rep
2020
PubMed ID: 32317652
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Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.
Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.
J Biosci Bioeng
2020
PubMed ID: 32636145
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Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide
Fundamental Toxicological Sciences
2020
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Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.
Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
R Soc Open Sci
2020
7(7):200027
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Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.
Protective Effects of Rice Peptide Oryza Peptide-P60 against Oxidative Injury through Activation of Nrf2 Signaling Pathway In Vitro and In Vivo
ACS Omega
2020
5(22):13096-13107
PubMed ID: 32548495
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Takagi K, Midorikawa Y, Takayama T, Abe H, Fujiwara K, Soma M, Nagase H, Miki T, Fukuda N.
Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells
Molecules
2020
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Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.
Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A
Anticancer Res
2020
40(1):161-168
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Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.
Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines
Toxicol In Vitro
2020
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Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.
Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells
J Histochem Cytochem
2019
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Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Virol. J.
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PubMed ID: 31046787
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Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.
Medicines (Basel)
2019
PubMed ID: 31163644
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Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.
Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.
Sci Rep
2019
PubMed ID: 31611630
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9810
Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
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Akito Endo, Shoichiro Asayama
Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery
Journal of Minerals and Materials Characterization and Engineering
2019
7:94802,8
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Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki
PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces
Sensors and Actuators B: Chemical
2019
287:486-495
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Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
J Pharm Pharm Sci
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PubMed ID: 31804920
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Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
2019
14(3):e0214000
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Morikawa T, Nagatomo A, Oka T, Miki Y, Taira N, Shibano-Kitahara M, Hori Y, Muraoka O, Ninomiya K.
Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism
Int J Mol Sci
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Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss.
BMC Complement Altern Med
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Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion
Int J Mol Sci
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Matsumura K, Imai H, Go Y, Kusuhara M, Yamaguchi K, Shirai T, Ohshima K.
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Gene
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Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.
Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.
Cell Commun. Signal
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J. Biosci. Bioeng.
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Nagatome M, Kondo Y, Kadowaki D, Saishyo Y, Irikura M, Irie T, Ishitsuka Y.
Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine.
Heliyon
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Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.
Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.
J Clin Biochem Nutr
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Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.
Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.
Br. J. Cancer
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Uemura T, Takasaka T, Igarashi K, Ikegaya H.
Spermine oxidase promotes bile canalicular lumen formation through acrolein production.
Sci Rep
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Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Kato N, Fujiwara T, Mizuguchi H.
uppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB
Mol Ther Oncolytics
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