| 利用者成果(英) |
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13453
SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor
Drug Metabolism and Pharmacokinetics
2021/4/1
PubMed ID: 33515843
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20006
Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.
Pharmaceutics
2021
13(1)
PubMed ID: 33430003
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20035
Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.
Glycoconj J
2021
38(1):45-54
PubMed ID: 33523362
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11062
Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto
Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation
Journal of Molecular Liquids
2020
299:112166
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12988
Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.
Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.
Sci Rep
2020
PubMed ID: 32317652
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13110
Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.
Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.
J Biosci Bioeng
2020
PubMed ID: 32636145
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13301
Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.
J Biomater Sci Polym Ed
2020
PubMed ID: 33074050
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13491
Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide
Fundamental Toxicological Sciences
2020
7 :161-166
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11540
Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Virol. J.
2019
PubMed ID: 31046787
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11585
Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.
Medicines (Basel)
2019
PubMed ID: 31163644
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9810
Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
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10371
Akito Endo, Shoichiro Asayama
Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery
Journal of Minerals and Materials Characterization and Engineering
2019
7:94802,8
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10854
Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki
PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces
Sensors and Actuators B: Chemical
2019
287:486-495
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12437
Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
2019
14(3):e0214000
PubMed ID: 30875389
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4214
Matsumura K, Imai H, Go Y, Kusuhara M, Yamaguchi K, Shirai T, Ohshima K.
Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor.
Gene
2018
PubMed ID: 30096459
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4216
Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.
Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.
Cell Commun. Signal
2018
PubMed ID: 30180849
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9973
Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.
Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.
J Clin Biochem Nutr
2017
60:115-120
PubMed ID: 28366990
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10185
Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.
Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.
Br. J. Cancer
2017
116:1046-1056
PubMed ID: 28291773
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10595
Uemura T, Takasaka T, Igarashi K, Ikegaya H.
Spermine oxidase promotes bile canalicular lumen formation through acrolein production.
Sci Rep
2017
7:14841
PubMed ID: 29093526
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12220
Shoichiro Asayama, Mizuki Sakata, Hiroyoshi Kawakami
Structure-activity relationship between Zn 2+-chelated alkylated poly(1-vinylimidazole) and gene transfection
J Inorg Biochem
2017
173:120-125
PubMed ID: 28511062
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9946
Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.
Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator.
J Toxicol Sci
2016
41:775-781
PubMed ID: 27853106
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10020
Moriyama K, Naito S, Wakabayashi R, Goto M, Kamiya N.
Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation.
Biotechnol J
2016
11:1452-1460
PubMed ID: 27617786
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4039
Oshikata-Miyazaki A, Takezawa T.
Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber.
Cytotechnology
2016
68(5):1801-11
PubMed ID: 26660096
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12685
Takei T, Kitazono J, Tanaka S, Nishimata H, Yoshida M.
Necrotic regions are absent in fiber-shaped cell aggregates, approximately 100 μm in diameter
Artif Cells Nanomed Biotechnol
2016
44(1):62-5
PubMed ID: 24813225
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12946
Yun YS, Tajima M, Takahashi S, Takahashi Y, Umemura M, Nakano H, Park HS, Inoue H.
Two Alkaloids from Bulbs of Lycoris sanguinea M AXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB
Phytother Res
2016
30(10):1689-1695
PubMed ID: 27388056
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7456
Okina Y, Takeuchi F, Yokomichi T, Takada Y, Kataoka T.
Cardenolide aglycones inhibit tumor necrosis factor α-induced expression of intercellular adhesion molecule-1 at the translation step by blocking Na⁺/K⁺-ATPase
Biol. Pharm. Bull.
2015
38:39-47
PubMed ID: 25744456
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7501
Lai YT, Sato M, Ohta S, Akamatsu K, Nakao S, Sakai Y, Ito T.
Preparation of uniform-sized hemoglobin-albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique.
Colloids Surf B Biointerfaces
2015
127:1-7
PubMed ID: 25635614
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7574
Yuji SHIBATA, Katsuhisa YAMADA, Chiaki IMADA, Takeshi KOBAYASHI, Takeshi TERAHARA
Phenotypic Characterization of a Microbe Producing Substances for Oxidative Stress Resistance Isolated from the Deep Seawater in Izu-Akazawa, Japan.
Deep Ocean Water Research
2015
15:117-124
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5372
Nakajima Y, Kanno T, Nagaya T, Kuribayashi K, Nakano T, Gotoh A, Nishizaki T.
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.
Cell Physiol Biochem
2015
35(1):51-60
PubMed ID: 25547995
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10275
Nobumasa Hara, Tomoko Shibata, Harumi Osago, Kazuo Yamada, Mikako Tsuchiya
Formation of [nicotinamide-²H₃]NAD⁺ From [²H₄]nicotinamide and [²H₄]nicotinic Acid in Human HepG2N Cells and Involvement of ²H/¹H Exchange at the Redox Site of NAD⁺/NADH
J Nutr Sci Vitaminol (Tokyo)
2014
60(1):17-21
PubMed ID: 24759255
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10281
Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa
Comparison of the Effects of Curcumin and Curcumin Glucuronide in Human Hepatocellular Carcinoma HepG2 Cells
Food Chem
2014
151:126-32
PubMed ID: 24423511
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5844
Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Pharmacology
2013
91(5-6):339-45
PubMed ID: 23817168
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12867
Hanada S, Fujioka K, Futamura Y, Manabe N, Hoshino A, Yamamoto K.
Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect
Int J Mol Sci
2013
14(1):1323-34
PubMed ID: 23306154
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7683
Fujii T, Minagawa T, Shimizu T, Takeguchi N, Sakai H.
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.
J Physiol Sci
2012
62:53-8
PubMed ID: 21932081
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12539
Kawano Y, Nagata M, Kohno T, Ichimiya A, Iwakiri T, Okumura M, Arimori K.
Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
Biol Pharm Bull
2012
35(3):400-7
PubMed ID: 22382328
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12727
Tamura K, Kanno T, Fujita Y, Gotoh A, Nakano T, Nishizaki T.
A(2a) adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-X(L) expression and upregulating Bid expression
J Cell Biochem
2012
113(5):1766-75.
PubMed ID: 22213163
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7642
Tagaya M, Yamazaki T, Tsuya D, Sugimoto Y, Hanagata N, Ikoma T.
Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion.
Macromol Biosci
2011
11:1586-93
PubMed ID: 22052565
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7988
Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.
Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
J. Agric. Food Chem.
2011
59:1470-6
PubMed ID: 21226458
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12747
Yaguchi T, Nakano T, Gotoh A, Nishizaki T.
Adenosine promotes GATA-2-regulated p53 gene transcription to induce HepG2 cell apoptosis
Cell Physiol Biochem
2011
28(4):761-70
PubMed ID: 22178888
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13678
Masuda M, Shimomura M, Kobayashi K, Kojima S, Nakatsura T.
Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines
Oncol Rep
2011
26(5):1273-9
PubMed ID: 21725613
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8211
Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.
Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.
J. Biosci. Bioeng.
2010
110:572-6
PubMed ID: 20591731
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8234
Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.
Cell micropatterning inside a microchannel and assays under a stable concentration gradient.
J. Biosci. Bioeng.
2010
110:230-7
PubMed ID: 20547384
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8237
Sakai Y, Yoshida S, Yoshiura Y, Mori R, Tamura T, Yahiro K, Mori H, Kanemura Y, Yamasaki M, Nakazawa K.
Effect of microwell chip structure on cell microsphere production of various animal cells.
J. Biosci. Bioeng.
2010
110:223-9
PubMed ID: 20547385
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12754
Yang D, Yaguchi T, Nakano T, Nishizaki T.
Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells
Cell Biol Toxicol
2010
26(4):319-30
PubMed ID: 20063052
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12757
Sato W, Suzuki H, Sasaki T, Kumagai T, Sakaguchi S, Mizugaki M, Miyairi S, Yamazoe Y, Nagata K.
Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid
Drug Metab Pharmacokinet
2010
25(2):180-9
PubMed ID: 20460824
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8705
Hattori N, Suzuki T, Jinno S, Okeya H, Ishikawa A, Kondo C, Hayashi T, Ito M, Kanamori T, Kawai T, Noguchi T.
Methyl methacrylate activates the Gsta1 promoter.
J. Dent. Res.
2008
87:1117-21
PubMed ID: 19029078
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8720
Mori R, Sakai Y, Nakazawa K.
Micropatterned organoid culture of rat hepatocytes and HepG2 cells.
J. Biosci. Bioeng.
2008
106:237-42
PubMed ID: 18929998
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8765
Saigo K, Yoshida K, Ikeda R, Sakamoto Y, Murakami Y, Urashima T, Asano T, Kenmochi T, Inoue I.
Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.
Hum. Mutat.
2008
29:703-8
PubMed ID: 18320596
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8786
Tamura T, Sakai Y, Nakazawa K.
Two-dimensional microarray of HepG2 spheroids using collagen/polyethylene glycol micropatterned chip.
J Mater Sci Mater Med
2008
19:2071-7
PubMed ID: 17968500
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12797
Yoshinari K, Ueda R, Kusano K, Yoshimura T, Nagata K, Yamazoe Y.
Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements
Biochem Pharmacol
2008
76(1):139-45
PubMed ID: 18502397
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13723
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy
J Exp Ther Oncol
2008
7(2):153-67
PubMed ID: 18771089
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
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3407
Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi
Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.
Am J Physiol Endocrinol Metab
2005
288:E1101-9
PubMed ID: 15671080
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
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9172
Harada K, Ohba K, Ozaki S, Isse K, Hirayama T, Wada A, Nakanuma Y.
Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree.
Hepatology
2004
40:925-32
PubMed ID: 15382127
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
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12845
Choi S, Nishikawa M, Sakoda A, Sakai Y.
Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity
Toxicol In Vitro
2004
18(3):393-402
PubMed ID: 15046787
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3793
Yoshida S, Honda A, Matsuzaki Y, Fukushima S, Tanaka N, Takagiwa A, Fujimoto Y, Miyazaki H, Salen G.
Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.
Steroids
2003
68(1):73-83
PubMed ID: 12475725
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
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9400
Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S.
Identification and characterization of the human long form of Sox5 (L-SOX5) gene.
Gene
2002
298:59-68
PubMed ID: 12406576
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3787
Mikiko Shimizu, Hiro-omi Tamura
Identification and Localization of Two Hydroxysteroid Sulfotransferases in the Human Brain
Journal of Health Science
2002
48:467-472
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3773
Hirano R, Igarashi O, Kondo K, Itakura H, Matsumoto A.
Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.
Lipids
2001
36(4):401-6
PubMed ID: 11383693
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6400
Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.
A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.
J Orthop Sci
2001
6(3):269-75
PubMed ID: 11484122
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