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HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.
J Toxicol Sci
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Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
J Nat Med
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Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.
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J Toxicol Sci
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Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.
Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.
Oncol Rep
2022
47(4)
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Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.
A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.
Nat Commun
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Kitano H, Kawabe Y, Kamihira M.
HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions
Cells
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Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.
J Biomater Sci Polym Ed
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SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor
Drug Metabolism and Pharmacokinetics
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Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
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Pharmaceutics
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Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.
Glycoconj J
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Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.
Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.
J Biochem
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El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.
Ann Surg Oncol
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Toshiaki TAKEZAWA
Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes
Nano Biomedicine
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Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.
A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment
Cancers (Basel)
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Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.
Int J Oncol
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A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals
Free Radic Biol Med
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Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation
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Sci Rep
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Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.
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J Biosci Bioeng
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Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide
Fundamental Toxicological Sciences
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Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.
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R Soc Open Sci
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Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.
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ACS Omega
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Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.
Medicines (Basel)
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Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
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Akito Endo, Shoichiro Asayama
Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery
Journal of Minerals and Materials Characterization and Engineering
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Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki
PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces
Sensors and Actuators B: Chemical
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Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism
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Cell Commun. Signal
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Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.
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Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber.
Cytotechnology
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Artif Cells Nanomed Biotechnol
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Two Alkaloids from Bulbs of Lycoris sanguinea M AXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB
Phytother Res
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Preparation of uniform-sized hemoglobin-albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique.
Colloids Surf B Biointerfaces
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Nakajima Y, Kanno T, Nagaya T, Kuribayashi K, Nakano T, Gotoh A, Nishizaki T.
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.
Cell Physiol Biochem
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Higashi T, Hayashi H, Ishimoto T, Takeyama H, Kaida T, Arima K, Taki K, Sakamoto K, Kuroki H, Okabe H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H.
miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells
Br J Cancer
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Motoyama K, Hirai Y, Nishiyama R, Maeda Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Era T, Arima H.
Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells
Beilstein J Org Chem
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Nobumasa Hara, Tomoko Shibata, Harumi Osago, Kazuo Yamada, Mikako Tsuchiya
Formation of [nicotinamide-²H₃]NAD⁺ From [²H₄]nicotinamide and [²H₄]nicotinic Acid in Human HepG2N Cells and Involvement of ²H/¹H Exchange at the Redox Site of NAD⁺/NADH
J Nutr Sci Vitaminol (Tokyo)
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Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa
Comparison of the Effects of Curcumin and Curcumin Glucuronide in Human Hepatocellular Carcinoma HepG2 Cells
Food Chem
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Naoki Tanigawa, Sachiko Yano, Akira Higashibata, Yoshikazu Tsuchiya, Haruna Tanii, Noboru Ando, Koji Kubota, Mutsumu Nagase
Development and Validation of a Closed Chamber for Cell Culture Experiments in Space
Biological Sciences in Space
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Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Pharmacology
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Hanada S, Fujioka K, Futamura Y, Manabe N, Hoshino A, Yamamoto K.
Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect
Int J Mol Sci
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Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.
Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers
Proc Natl Acad Sci U S A
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Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation
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Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
Biol Pharm Bull
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A(2a) adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-X(L) expression and upregulating Bid expression
J Cell Biochem
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Macromol Biosci
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J. Agric. Food Chem.
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Adenosine promotes GATA-2-regulated p53 gene transcription to induce HepG2 cell apoptosis
Cell Physiol Biochem
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Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines
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Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.
J. Biosci. Bioeng.
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Sakai Y, Yoshida S, Yoshiura Y, Mori R, Tamura T, Yahiro K, Mori H, Kanemura Y, Yamasaki M, Nakazawa K.
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J. Biosci. Bioeng.
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Cell Biol Toxicol
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Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid
Drug Metab Pharmacokinet
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Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes
Mol Microbiol
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Biochem Pharmacol
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Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy
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Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
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3407
Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi
Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.
Am J Physiol Endocrinol Metab
2005
288:E1101-9
PubMed ID: 15671080
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14325
Sugatani J, Sueyoshi T, Negishi M, Miwa M.
Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor
Methods Enzymol
2005
400:92-104
PubMed ID: 16399345
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
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9172
Harada K, Ohba K, Ozaki S, Isse K, Hirayama T, Wada A, Nakanuma Y.
Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree.
Hepatology
2004
40:925-32
PubMed ID: 15382127
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
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12845
Choi S, Nishikawa M, Sakoda A, Sakai Y.
Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity
Toxicol In Vitro
2004
18(3):393-402
PubMed ID: 15046787
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3793
Yoshida S, Honda A, Matsuzaki Y, Fukushima S, Tanaka N, Takagiwa A, Fujimoto Y, Miyazaki H, Salen G.
Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.
Steroids
2003
68(1):73-83
PubMed ID: 12475725
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
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14329
Hata K, Hori K, Ogasawara H, Takahashi S.
Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene
Toxicol Lett
2003
143(1):1-7
PubMed ID: 12697374
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9400
Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S.
Identification and characterization of the human long form of Sox5 (L-SOX5) gene.
Gene
2002
298:59-68
PubMed ID: 12406576
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3787
Mikiko Shimizu, Hiro-omi Tamura
Identification and Localization of Two Hydroxysteroid Sulfotransferases in the Human Brain
Journal of Health Science
2002
48:467-472
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3773
Hirano R, Igarashi O, Kondo K, Itakura H, Matsumoto A.
Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.
Lipids
2001
36(4):401-6
PubMed ID: 11383693
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6400
Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.
A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.
J Orthop Sci
2001
6(3):269-75
PubMed ID: 11484122
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