検索画面
細胞材料開発室サイト

戻る 戻る
細胞番号 : 細胞名
RCB1648 : Hep G2  update : 2024/09/19
細胞特性(Comment:英)Human cell line derived from hepatoblastoma. Secretes several products such as albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 85011430 prior to order. Information
細胞特性(日)ヒト肝芽腫由来細胞株。albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin, plasminogenなどを分泌。ECACC由来株。使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、ECACC 85011430 を必ずご参照ください。Hep G2細胞の由来について
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85011430 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)1) 基礎的研究につきましては、使用制限はありません。しかし、使用条件等がECACCによって随時変更となる可能性があるので、購入前に、ECA85011430 を必ず参照すること。2) 商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 2000
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Male
15 years
採取組織 liver
病名 hepatocyte carcinoma
細胞分類 cancer
入手歴 overseas, Dr.Knowles (Wistar Institute, Ohiladelphoa) -> ECACC -> RIKEN Cell Bank
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0027
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS + 0.1mM NEAA
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 4-8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
ウィルス(HBV) (-)
ウィルス(HCV) (-)
アイソザイム検査 LD, NP
染色体検査 51-53(50) : 51(12).52(22),53(16)
個体識別検査 OK
文献情報 Reference(英) 5件
Reference(日) 1件
利用者成果(英) 163件
利用者成果(日) 0件

トップへページトップへ
Reference(英)
11987  Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles  Hep G2 is a hepatoblastoma-derived cell line  Hum Pathol  2009  40(10):1512-5  PubMed ID: 19751877   DOI: 10.1016/j.humpath.2009.07.003
1156  Darlington GJ, Kelly JH, Buffone GJ.  Growth and hepatospecific gene expression of human hepatoma cells in a defined medium  In Vitro Cell Dev Biol  1987  23(5):349-54.  PubMed ID: 3034851   DOI: 10.1007/BF02620991
1155  Knowles, B B, Howe, C C, Aden, D P  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.  Science  1980  209:497-9  PubMed ID: 6248960   DOI: 10.1126/science.6248960
4984  Diamond L1, Kruszewski F, Aden DP, Knowles BB, Baird WM.  Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.  Carcinogenesis  1980  1(10):871-5  PubMed ID: 11219860   DOI: 10.1093/carcin/1.10.871
465  Aden, D P, Fogel A, Plotkin S, Damjanov I, Knowles, B B  Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.  Nature  1979  282:615-6  PubMed ID: 233137   DOI: 10.1038/282615a0

トップへページトップへ
Reference(日)
1707  堀内龍也  ヒト : Hep G2  生体の科学  1992  43:383-384   

トップへページトップへ
利用者成果(英)
21548  Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.  An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.  J Pharmacol Sci  2024  154(1):37-46  PubMed ID: 38081682   DOI: 10.1016/j.jphs.2023.11.005
21661  Katoh M, Fujii T, Tabuchi Y, Shimizu T, Sakai H.  Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.  J Physiol Sci  2024  74(1):23  PubMed ID: 38561668   DOI: 10.1186/s12576-024-00914-7
21904  Negoro R, Ouchi A, Deguchi S, Takayama K, Fujita T.  Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.  Biol Pharm Bull  2024  47(8):1422-1428  PubMed ID: 39111864   DOI: 10.1248/bpb.b24-00202
22004  Urakawa D, Shioiridani Y, Igata S, Hou DX, Sakao K.  Comparative Analysis of Acetylated Flavonoids' Chemopreventive Effects in Different Cancer Cell Lines  Int J Mol Sci  2024  25(14):7689.  PubMed ID: 39062932   DOI: 10.3390/ijms25147689
22095  Toma T, Miyakawa N, Arakaki Y, Watanabe T, Nakahara R, Ali TFS, Biswas T, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.  An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models.  Diabetologia  2024  67(11):2568-2584  PubMed ID: 39251430   DOI: 10.1007/s00125-024-06260-y
19558  Kurawaka M, Sasaki N, Yamazaki Y, Shimura F.  Near-Physiological Concentrations of Extracellular Pyruvate Stimulated Glucose Utilization along with Triglyceride Accumulation and Mitochondrial Activity in HepG2 Cells  J Nutr Sci Vitaminol (Tokyo)  2023  69(5):314-325  PubMed ID: 37940572   DOI: 10.3177/jnsv.69.314
19640  Sakao K, Saruwatari H, Minami S, Hou DX.  Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells  Int J Mol Sci  2023  24(23):16652  PubMed ID: 38068974   DOI: 10.3390/ijms242316652
19644  Nakamura M, Urakawa D, He Z, Akagi I, Hou DX, Sakao K.  Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II)  Int J Mol Sci  2023  24(24):17457  PubMed ID: 38139286   DOI: 10.3390/ijms242417457
19989  Kodama S, Matsumoto S, Takamura Y, Fujihara M, Watanabe M, Ono A, Kakuta H.  Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha  Toxicol Lett  2023  15:373:76-83.  PubMed ID: 36368620   DOI: 10.1016/j.toxlet.2022.11.003
21179  Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.  Lysine long-chain fatty acylation regulates the TEAD transcription factor.  Cell Rep  2023  112388  PubMed ID: 37060904   DOI: 10.1016/j.celrep.2023.112388
21481  Nagatomo A, Kohno M, Kawakami H, Manse Y, Morikawa T.  Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver.  J Nat Med  2023    PubMed ID: 37973705   DOI: 10.1007/s11418-023-01756-0
22032  Shizu R, Otsuka Y, Ishii C, Ezaki K, Yoshinari K.  PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers.  Int J Mol Sci  2023  24(4)  PubMed ID: 36835365   DOI: 10.3390/ijms24043953
17664  Matsumura M, Murakami M, Funaba M.  Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family  Cell Biochem Funct   2022  ;40(7):742-749  PubMed ID: 36062805   DOI: 10.1002/cbf.3739
17682  Okumura M, Iwakiri T, Yoshikawa N, Nagatomo T, Ayabe T, Tsuneyoshi I, Ikeda R.  Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells  Int J Mol Sci  2022  23(16):9108  PubMed ID: 36012373   DOI: 10.3390/ijms23169108
20482  Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.  Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.  Int J Oncol  2022  60(1)  PubMed ID: 34913069   DOI: 10.3892/ijo.2021.5294
20514  Takezawa T, Uzu M.  HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.  J Toxicol Sci  2022  47(1):39-50  PubMed ID: 34987140   DOI: 10.2131/jts.47.39
20608  Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.  Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.  J Nat Med  2022    PubMed ID: 35292883   DOI: 10.1007/s11418-022-01614-5
20639  Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.  Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.  Oncol Rep  2022  47(4)  PubMed ID: 35169858   DOI: 10.3892/or.2022.8282
20691  Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.  A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.  Nat Commun  2022  13(1):2533  PubMed ID: 35534485   DOI: 10.1038/s41467-022-30153-6
16451  Kitano H, Kawabe Y, Kamihira M.  HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions  Cells  2022  11(7):1194  PubMed ID: 35406758   DOI: 10.3390/cells11071194
16644  Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.  Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System  Cells  2022  11(10):1677  PubMed ID: 35626714   DOI: 10.3390/cells11101677
20752  Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.  Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.  J Toxicol Sci  2022  47(6):249-255  PubMed ID: 35650141   DOI: 10.2131/jts.47.249
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20840  Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.  Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.  Sci Rep  2022  12(1):14520  PubMed ID: 36008442   DOI: 10.1038/s41598-022-18572-3
20842  Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.  Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.  J Oral Microbiol  2022  14(1):2105013  PubMed ID: 35937899   DOI: 10.1080/20002297.2022.2105013
20911  Imanishi S, Nagata S, Fujita T, Fujii H.  Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.  Int J Exp Pathol  2022    PubMed ID: 36153641   DOI: 10.1111/iep.12457
20926  Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.  Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.  Redox Biol  2022  57:102514  PubMed ID: 36279630   DOI: 10.1016/j.redox.2022.102514
22034  Nagatomo A, Ninomiya K, Marumoto S, Sakai C, Watanabe S, Ishikawa W, Manse Y, Kikuchi T, Yamada T, Tanaka R, Muraoka O, Morikawa T.  A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells.  Int J Mol Sci  2022  23(21)  PubMed ID: 36361930   DOI: 10.3390/ijms232113141
13301  Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.  Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.  J Biomater Sci Polym Ed  2021  32(3):405-416  PubMed ID: 33074050   DOI: 10.1080/09205063.2020.1838045
13453  SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima  Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor  Drug Metabolism and Pharmacokinetics  2021    PubMed ID: 33515843   DOI: 10.1016/j.dmpk.2020.11.002
20006  Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.  Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.  Pharmaceutics  2021  13(1)  PubMed ID: 33430003   DOI: 10.3390/pharmaceutics13010078
20035  Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.  Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.  Glycoconj J  2021  38(1):45-54  PubMed ID: 33523362   DOI: 10.1007/s10719-020-09970-8
20110  Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.  Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.  J Biochem  2021    PubMed ID: 33844018   DOI: 10.1093/jb/mvab049
20136  El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.  MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33886022   DOI: 10.1245/s10434-021-09778-2
15116  Toshiaki TAKEZAWA  Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes  Nano Biomedicine  2021  13:1-7    DOI: 10.11344/nano.13.1
15515  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.  A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment  Cancers (Basel)  2021  13(16):3997  PubMed ID: 34439154   DOI: 10.3390/cancers13163997
16049  Endo A, Asayama S.  Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization  Pharmaceutics  2021  13(12):2084  PubMed ID: 34959365   DOI: 10.3390/pharmaceutics13122084
16135  Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.  A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals  Free Radic Biol Med  2021  163:297-305  PubMed ID: 33359688   DOI: 10.1016/j.freeradbiomed.2020.12.028
20621  Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.  Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.  J Toxicol Sci  2021  46(12):569-587  PubMed ID: 34853243   DOI: 10.2131/jts.46.569
16527  Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.  Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach  Tumour Biol  2021  43(1):309-325  PubMed ID: 34897107   DOI: 10.3233/TUB-211507
16876  Takemura A, Gong S, Sato T, Kawaguchi M, Sekine S, Kazuki Y, Horie T, Ito K.  Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells  J Pharm Sci  2021  110(9):3306-3312  PubMed ID: 34097978   DOI: 10.1016/j.xphs.2021.06.001
16984  Kawase A, Hirosoko M, Sugihara Y, Koyama Y, Fukae A, Shimada H, Iwaki M.  NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells  Pharmaceuticals (Basel)  2021  14(3):239.  PubMed ID: 33800412   DOI: 10.3390/ph14030239
22037  Tsuji T, Morita SY, Nakamura Y, Ikeda Y, Kambe T, Terada T.  Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth.  Sci Rep  2021  11(1):2731  PubMed ID: 33526799   DOI: 10.1038/s41598-021-81733-3
11062  Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto  Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation  Journal of Molecular Liquids  2020  299:112166    DOI: 10.1016/j.molliq.2019.112166
12988  Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.  Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.  Sci Rep  2020    PubMed ID: 32317652   DOI: 10.1038/s41598-020-63362-4
13110  Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.  Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.  J Biosci Bioeng  2020    PubMed ID: 32636145   DOI: 10.1016/j.jbiosc.2020.05.010
13491  Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai  Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide  Fundamental Toxicological Sciences  2020  7 :161-166    DOI: 10.2131/fts.7.161
14497  Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.  Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device  R Soc Open Sci  2020  7(7):200027  PubMed ID: 32874617   DOI: 10.1098/rsos.200027
14851  Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.  Protective Effects of Rice Peptide Oryza Peptide-P60 against Oxidative Injury through Activation of Nrf2 Signaling Pathway In Vitro and In Vivo  ACS Omega  2020  5(22):13096-13107  PubMed ID: 32548495   DOI: 10.1021/acsomega.0c01016
15192  Takagi K, Midorikawa Y, Takayama T, Abe H, Fujiwara K, Soma M, Nagase H, Miki T, Fukuda N.  Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells  Molecules  2020  25(12):2883  PubMed ID: 32585841   DOI: 10.3390/molecules25122883
16623  Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.  Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A  Anticancer Res  2020  40(1):161-168  PubMed ID: 31892564   DOI: 10.21873/anticanres.13937
16883  Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.  Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines  Toxicol In Vitro  2020  69:104999.  PubMed ID: 32949729   DOI: 10.1016/j.tiv.2020.104999
17874  Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.  Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells  J Histochem Cytochem  2019  67(2):129-141  PubMed ID: 30303767   DOI: 10.1369/0022155418804507
11540  Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.  A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.  Virol. J.  2019    PubMed ID: 31046787   DOI: 10.1186/s12985-019-1169-x
11585  Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.  Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.  Medicines (Basel)  2019    PubMed ID: 31163644   DOI: 10.3390/medicines6020063
11851  Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.  Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.  Sci Rep  2019    PubMed ID: 31611630   DOI: 10.1038/s41598-019-51462-9
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
10371  Akito Endo, Shoichiro Asayama  Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery  Journal of Minerals and Materials Characterization and Engineering  2019  7:94802,8    DOI: 10.4236/jmmce.2019.75016
10854  Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki  PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces  Sensors and Actuators B: Chemical  2019  287:486-495    DOI: 10.1016/j.snb.2019.02.067
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920   DOI: 10.18433/jpps30444
12437  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.  Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry  PLoS One  2019  14(3):e0214000  PubMed ID: 30875389   DOI: 10.1371/journal.pone.0214000
14893  Morikawa T, Nagatomo A, Oka T, Miki Y, Taira N, Shibano-Kitahara M, Hori Y, Muraoka O, Ninomiya K.  Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism  Int J Mol Sci  2019  ;20(24):6322  PubMed ID: 31847420   DOI: 10.3390/ijms20246322
21997  Zohra T, Ovais M, Khalil AT, Qasim M, Ayaz M, Shinwari ZK, Ahmad S, Zahoor M.  Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss.  BMC Complement Altern Med  2019  19(1):4  PubMed ID: 30606171   DOI: 10.1186/s12906-018-2416-1
19234  Tsuchiya H, Oura S.  Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion  Int J Mol Sci  2018  19(5):1450  PubMed ID: 29757260   DOI: 10.3390/ijms19051450
4214  Matsumura K, Imai H, Go Y, Kusuhara M, Yamaguchi K, Shirai T, Ohshima K.  Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor.  Gene  2018    PubMed ID: 30096459   DOI: 10.1016/j.gene.2018.08.033
4216  Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.  Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.  Cell Commun. Signal  2018    PubMed ID: 30180849   DOI: 10.1186/s12964-018-0262-x
4222  Miyamoto D, Hara T, Hyakutake A, Nakazawa K.  Changes in HepG2 spheroid behavior induced by differences in the gap distance between spheroids in a micropatterned culture system.  J. Biosci. Bioeng.  2018    PubMed ID: 29352710   DOI: 10.1016/j.jbiosc.2017.12.013
4340  Nagatome M, Kondo Y, Kadowaki D, Saishyo Y, Irikura M, Irie T, Ishitsuka Y.  Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine.  Heliyon  2018    PubMed ID: 29560444   DOI: 10.1016/j.heliyon.2018.e00521
9973  Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.  Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.  J Clin Biochem Nutr  2017  60:115-120  PubMed ID: 28366990   DOI: 10.3164/jcbn.16-44
10185  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773   DOI: 10.1038/bjc.2017.65
10595  Uemura T, Takasaka T, Igarashi K, Ikegaya H.  Spermine oxidase promotes bile canalicular lumen formation through acrolein production.  Sci Rep  2017  7:14841  PubMed ID: 29093526   DOI: 10.1038/s41598-017-14929-1
19317  Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Kato N, Fujiwara T, Mizuguchi H.  uppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB  Mol Ther Oncolytics  2017  7:76-85  PubMed ID: 29202008   DOI: 10.1016/j.omto.2017.10.003
12220  Shoichiro Asayama, Mizuki Sakata, Hiroyoshi Kawakami  Structure-activity relationship between Zn 2+-chelated alkylated poly(1-vinylimidazole) and gene transfection  J Inorg Biochem  2017  173:120-125  PubMed ID: 28511062   DOI: 10.1016/j.jinorgbio.2017.05.007
14592  Kusama K, Okamoto Y, Saito K, Kasahara T, Murata T, Ueno Y, Kobayashi Y, Kamada Y, Miyoshi E.  Reevaluation of Pholiota squarrosa lectin-reactive haptoglobin as a pancreatic cancer biomarker using an improved ELISA system  Glycoconj J  2017  34(4):537-544  PubMed ID: 28455724   DOI: 10.1007/s10719-017-9772-9
14609  Enomoto J, Kageyama T, Osaki T, Bonalumi F, Marchese F, Gautieri A, Bianchi E, Dubini G, Arrigoni C, Moretti M, Fukuda J.  Catch-and-Release of Target Cells Using Aptamer-Conjug  Sci Rep  2017  7:43375  PubMed ID: 28266533   DOI: 10.1038/srep43375
21998  Zahra SS, Ahmed M, Qasim M, Gul B, Zia M, Mirza B, Haq IU.  Polarity based characterization of biologically active extracts of Ajuga bracteosa Wall. ex Benth. and RP-HPLC analysis.  BMC Complement Altern Med  2017  17(1):443  PubMed ID: 28870197   DOI: 10.1186/s12906-017-1951-5
21999  Ahmed M, Fatima H, Qasim M, Gul B, Ihsan-Ul-Haq.  Polarity directed optimization of phytochemical and in vitro biological potential of an indigenous folklore: Quercus dilatata Lindl. ex Royle.  BMC Complement Altern Med  2017  17(1):386  PubMed ID: 28774308   DOI: 10.1186/s12906-017-1894-x
9576  Sugai S, Yoshikawa T, Iwama T, Tsuchiya N, Ueda N, Fujinami N, Shimomura M, Zhang R, Kaneko S, Uemura Y, Nakatsura T.  Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate.  Int. J. Oncol.  2016  48:1794-804  PubMed ID: 26936487   DOI: 10.3892/ijo.2016.3403
9946  Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.  Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator.  J Toxicol Sci  2016  41:775-781  PubMed ID: 27853106   DOI: 10.2131/jts.41.775
10020  Moriyama K, Naito S, Wakabayashi R, Goto M, Kamiya N.  Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation.  Biotechnol J  2016  11:1452-1460  PubMed ID: 27617786   DOI: 10.1002/biot.201600087
19281  Kitagawa N, Ninomiya K, Okugawa S, Motaia C, Nakanishi Y, Yoshikawa M, Muraoka O, Morikawa T.  Quantitative Determination of Principal Alkaloid and Flavonoid Constituents in Wintersweet, the Flower Buds of Chimonanthuspraecox  Nat Prod Commun  2016  11(7):953-956  PubMed ID: 30452170  
4039  Oshikata-Miyazaki A, Takezawa T.  Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber.  Cytotechnology  2016  68(5):1801-11  PubMed ID: 26660096   DOI: 10.1007/s10616-015-9934-1
12685  Takei T, Kitazono J, Tanaka S, Nishimata H, Yoshida M.  Necrotic regions are absent in fiber-shaped cell aggregates, approximately 100 μm in diameter  Artif Cells Nanomed Biotechnol  2016  44(1):62-5  PubMed ID: 24813225   DOI: 10.3109/21691401.2014.909824
12946  Yun YS, Tajima M, Takahashi S, Takahashi Y, Umemura M, Nakano H, Park HS, Inoue H.  Two Alkaloids from Bulbs of Lycoris sanguinea M AXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB  Phytother Res  2016  30(10):1689-1695  PubMed ID: 27388056   DOI: 10.1002/ptr.5676
7373  Takei T, Aokawa R, Shigemitsu T, Kawakami K, Yoshida M.  Fabrication of uniformly cell-laden porous scaffolds using a gas-in-liquid templating technique.  J. Biosci. Bioeng.  2015  120:577-81  PubMed ID: 25912452   DOI: 10.1016/j.jbiosc.2015.03.017
7456  Okina Y, Takeuchi F, Yokomichi T, Takada Y, Kataoka T.  Cardenolide aglycones inhibit tumor necrosis factor α-induced expression of intercellular adhesion molecule-1 at the translation step by blocking Na⁺/K⁺-ATPase  Biol. Pharm. Bull.  2015  38:39-47  PubMed ID: 25744456   DOI: 10.1248/bpb.b14-00532
7501  Lai YT, Sato M, Ohta S, Akamatsu K, Nakao S, Sakai Y, Ito T.  Preparation of uniform-sized hemoglobin-albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique.  Colloids Surf B Biointerfaces  2015  127:1-7  PubMed ID: 25635614   DOI: 10.1016/j.colsurfb.2015.01.018
5372  Nakajima Y, Kanno T, Nagaya T, Kuribayashi K, Nakano T, Gotoh A, Nishizaki T.  Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.  Cell Physiol Biochem  2015  35(1):51-60  PubMed ID: 25547995   DOI: 10.1159/000369674
14967  Higashi T, Hayashi H, Ishimoto T, Takeyama H, Kaida T, Arima K, Taki K, Sakamoto K, Kuroki H, Okabe H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H.  miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells  Br J Cancer  2015  113(2):252-8  PubMed ID: 26125451   DOI: 10.1038/bjc.2015.170
15231  Motoyama K, Hirai Y, Nishiyama R, Maeda Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Era T, Arima H.  Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells  Beilstein J Org Chem  2015  11:2079-86  PubMed ID: 26664628   DOI: 10.3762/bjoc.11.224
5589  Ozeki M, Kato H, Tamaki K.  Development of a novel miniplex DNA identification system for the Japanese population  Leg Med (Tokyo)  2015  17(3):205-9  PubMed ID: 25596639   DOI: 10.1016/j.legalmed.2014.12.007
18174  Tameda M, Sugimoto K, Shiraki K, Yamamoto N, Okamoto R, Usui M, Ito M, Takei Y, Nobori T, Kojima T, Suzuki H, Uchida M, Uchida K.  Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility  Int J Oncol  2014  45(2):541-8  PubMed ID: 24841500   DOI: 10.3892/ijo.2014.2445
18953  Ninomiya K, Kawabata S, Tashita H, Shimizu N.  Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer  Ultrason Sonochem  2014  21(1):310-6  PubMed ID: 23948493   DOI: 10.1016/j.ultsonch.2013.07.014
10275  Nobumasa Hara, Tomoko Shibata, Harumi Osago, Kazuo Yamada, Mikako Tsuchiya  Formation of [nicotinamide-²H₃]NAD⁺ From [²H₄]nicotinamide and [²H₄]nicotinic Acid in Human HepG2N Cells and Involvement of ²H/¹H Exchange at the Redox Site of NAD⁺/NADH  J Nutr Sci Vitaminol (Tokyo)  2014  60(1):17-21  PubMed ID: 24759255   DOI: 10.3177/jnsv.60.17
10281  Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa  Comparison of the Effects of Curcumin and Curcumin Glucuronide in Human Hepatocellular Carcinoma HepG2 Cells  Food Chem  2014  151:126-32  PubMed ID: 24423511   DOI: 10.1016/j.foodchem.2013.11.021
14194  Naoki Tanigawa, Sachiko Yano, Akira Higashibata, Yoshikazu Tsuchiya, Haruna Tanii, Noboru Ando, Koji Kubota, Mutsumu Nagase  Development and Validation of a Closed Chamber for Cell Culture Experiments in Space  Biological Sciences in Space  2014  28:1-5    DOI: 10.2187/bss.28.1
17095  Mori M, Tiang G, Higuchi K.  AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform  Amyloid  2014  21(1):1-8  PubMed ID: 24228751   DOI: 10.3109/13506129.2013.852529
18855  Hirano S, Kataoka T.  Deoxynivalenol induces ectodomain shedding of TNF receptor 1 and thereby inhibits the TNF-α-induced NF-κB signaling pathway  Eur J Pharmacol  2013  701(1-3):144-51  PubMed ID: 23357557   DOI: 10.1016/j.ejphar.2013.01.019
18957  Ninomiya K, Kaneda K, Kawashima S, Miyachi Y, Ogino C, Shimizu N.  Cell-SELEX based selection and characterization of DNA aptamer recognizing human hepatocarcinoma  Bioorg Med Chem Lett  2013  23(6):1797-802  PubMed ID: 23403083   DOI: 10.1016/j.bmcl.2013.01.040
18992  Yun YS, Noda S, Shigemori G, Kuriyama R, Takahashi S, Umemura M, Takahashi Y, Inoue H.  Phenolic diterpenes from rosemary suppress cAMP responsiveness of gluconeogenic gene promoters  Phytother Res  2013  27(6):906-10  PubMed ID: 22927089   DOI: 10.1002/ptr.4794
19097  Orimoto A, Suzuki T, Ueno A, Kawai T, Nakamura H, Kanamori T.  Effect of 2-hydroxyethyl methacrylate on antioxidant responsive element-mediated transcription: a possible indication of its cytotoxicity  PLoS One  2013  8(3):e58907  PubMed ID: 23516576   DOI: 10.1371/journal.pone.0058907
5844  Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.  1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.  Pharmacology  2013  91(5-6):339-45  PubMed ID: 23817168   DOI: 10.1159/000351747
12867  Hanada S, Fujioka K, Futamura Y, Manabe N, Hoshino A, Yamamoto K.  Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect  Int J Mol Sci  2013  14(1):1323-34  PubMed ID: 23306154   DOI: 10.3390/ijms14011323
15922  Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.  Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers  Proc Natl Acad Sci U S A   2013  110(6):2105-10  PubMed ID: 23345451   DOI: 10.1073/pnas.1214233110
15936  Kondo Y, Ishitsuka Y, Kadowaki D, Fukumoto Y, Miyamoto Y, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T.  Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation  J Pharm Pharmacol  2013  65(3):390-401  PubMed ID: 23356848   DOI: 10.1111/j.2042-7158.2012.01602.x
16610  Abiko Y, Kumagai Y.  Interaction of Keap1 modified by 2-tert-butyl-1,4-benzoquinone with GSH: evidence for S-transarylatio  Chem Res Toxicol  2013  26(7):1080-7  PubMed ID: 23718696   DOI: 10.1021/tx400085h
7683  Fujii T, Minagawa T, Shimizu T, Takeguchi N, Sakai H.  Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.  J Physiol Sci  2012  62:53-8  PubMed ID: 21932081   DOI: 10.1007/s12576-011-0176-5
18568  Kimura T, Yoshida K, Yamamoto C, Suzuki M, Uno T, Isobe M, Naka H, Yasuike S, Satoh M, Kaji T, Uchiyama M.  Bis(L-cysteinato)zincate(lI) as a coordination compound that induces metallothionein gene transcription without inducing cell-stress-related gene transcription  J Inorg Biochem  2012  117:140-6  PubMed ID: 23085594   DOI: 10.1016/j.jinorgbio.2012.07.021
12539  Kawano Y, Nagata M, Kohno T, Ichimiya A, Iwakiri T, Okumura M, Arimori K.  Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells  Biol Pharm Bull  2012  35(3):400-7  PubMed ID: 22382328   DOI: 10.1248/bpb.35.400
12727  Tamura K, Kanno T, Fujita Y, Gotoh A, Nakano T, Nishizaki T.  A(2a) adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-X(L) expression and upregulating Bid expression  J Cell Biochem  2012  113(5):1766-75.  PubMed ID: 22213163   DOI: 10.1002/jcb.24048
15749  Fukuda J, Takahashi S, Osaki T, Mochizuki N, Suzuki H.  Processing of nanolitre liquid plugs for microfluidic cell-based assays  Sci Technol Adv Mater  2012  13(6):064201  PubMed ID: 27877528   DOI: 10.1088/1468-6996/13/6/064201
7642  Tagaya M, Yamazaki T, Tsuya D, Sugimoto Y, Hanagata N, Ikoma T.  Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion.  Macromol Biosci  2011  11:1586-93  PubMed ID: 22052565   DOI: 10.1002/mabi.201100182
7988  Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.  Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.  J. Agric. Food Chem.  2011  59:1470-6  PubMed ID: 21226458   DOI: 10.1021/jf103820b
18578  Haque A, Hexig B, Meng Q, Hossain S, Nagaoka M, Akaike T.  The effect of recombinant E-cadherin substratum on the differentiation of endoderm-derived hepatocyte-like cells from embryonic stem cells  Biomaterials  2011  32(8):2032-42  PubMed ID: 21163520   DOI: 10.1016/j.biomaterials.2010.11.045
12747  Yaguchi T, Nakano T, Gotoh A, Nishizaki T.  Adenosine promotes GATA-2-regulated p53 gene transcription to induce HepG2 cell apoptosis  Cell Physiol Biochem  2011  28(4):761-70  PubMed ID: 22178888   DOI: 10.1159/000335770
13678  Masuda M, Shimomura M, Kobayashi K, Kojima S, Nakatsura T.  Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines  Oncol Rep  2011  26(5):1273-9  PubMed ID: 21725613   DOI: 10.3892/or.2011.1370
8211  Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.  Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.  J. Biosci. Bioeng.  2010  110:572-6  PubMed ID: 20591731   DOI: 10.1016/j.jbiosc.2010.05.013
8234  Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.  Cell micropatterning inside a microchannel and assays under a stable concentration gradient.  J. Biosci. Bioeng.  2010  110:230-7  PubMed ID: 20547384   DOI: 10.1016/j.jbiosc.2010.02.001
8237  Sakai Y, Yoshida S, Yoshiura Y, Mori R, Tamura T, Yahiro K, Mori H, Kanemura Y, Yamasaki M, Nakazawa K.  Effect of microwell chip structure on cell microsphere production of various animal cells.  J. Biosci. Bioeng.  2010  110:223-9  PubMed ID: 20547385   DOI: 10.1016/j.jbiosc.2010.01.021
8454  Yang D, Yaguchi T, Lim CR, Ishizawa Y, Nakano T, Nishizaki T.  Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.  Cancer Lett.  2010  291:225-9  PubMed ID: 19900759   DOI: 10.1016/j.canlet.2009.10.016
18483  Imura Y, Sato K, Yoshimura E.  Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity  Anal Chem  2010  82(24):9983-8  PubMed ID: 21090751   DOI: 10.1021/ac100806x
18716  Norikura T, Mukai Y, Fujita S, Mikame K, Funaoka M, Sato S.  Lignophenols decrease oleate-induced apolipoprotein-B secretion in HepG2 cells  Basic Clin Pharmacol Toxicol  2010  107(4):813-7  PubMed ID: 20412465   DOI: 10.1111/j.1742-7843.2010.00575.x
18768  Goda T, Goto Y, Ishihara K.  Cell-penetrating macromolecules: direct penetration of amphipathic phospholipid polymers across plasma membrane of living cells  Biomaterials  2010  31(8):2380-7  PubMed ID: 20004016   DOI: 10.1016/j.biomaterials.2009.11.095
18899  Suzuki H, Sasaki T, Kumagai T, Sakaguchi S, Nagata K.  Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs)  J Toxicol Sci  2010  35(2):137-47  PubMed ID: 20371965   DOI: 10.2131/jts.35.137
18985  Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells  Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells  J Toxicol Sci  2010  35(3):419-23  PubMed ID: 20519851   DOI: 10.2131/jts.35.419
18986  Yamazaki T, Ohmi A, Kurumaya H, Kato K, Abe T, Yamamoto H, Nakanishi N, Okuyama R, Umemura M, Kaise T, Watanabe R, Okawa Y, Takahashi S, Takahashi Y.  Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells  Life Sci  2010  87(9-10):294-301  PubMed ID: 20654631   DOI: 10.1016/j.lfs.2010.07.006
19107  Shibuya K, Fukuoka J, Fujii T, Shimoda E, Shimizu T, Sakai H, Tsukada K.  Increase in ouabain-sensitive K+-ATPase activity in hepatocellular carcinoma by overexpression of Na+, K+-ATPase alpha 3-isoform  Eur J Pharmacol  2010  638(1-3):42-6  PubMed ID: 20447393   DOI: 10.1016/j.ejphar.2010.04.029
12754  Yang D, Yaguchi T, Nakano T, Nishizaki T.  Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells  Cell Biol Toxicol  2010  26(4):319-30  PubMed ID: 20063052   DOI: 10.1007/s10565-009-9145-7
12757  Sato W, Suzuki H, Sasaki T, Kumagai T, Sakaguchi S, Mizugaki M, Miyairi S, Yamazoe Y, Nagata K.  Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid  Drug Metab Pharmacokinet  2010  25(2):180-9  PubMed ID: 20460824   DOI: 10.2133/dmpk.25.180
15367  Miki T, Iguchi M, Akiba K, Hosono M, Sobue T, Danbara H, Okada N.  Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes  Mol Microbiol  2010  77(4):855-72  PubMed ID: 20545857   DOI: 10.1111/j.1365-2958.2010.07248.x
16392  Plessy C, Bertin N, Takahashi H, Simone R, Salimullah M, Lassmann T, Vitezic M, Severin J, Olivarius S, Lazarevic D, Hornig N, Orlando V, Bell I, Gao H, Dumais J, Kapranov P, Wang H, Davis CA, Gingeras TR, Kawai J, Daub CO, Hayashizaki Y, Gustincich S, Carninci P.  Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan  Nat Methods  2010  7(7):528-34  PubMed ID: 20543846   DOI: 10.1038/nmeth.1470
18456  Kikuchi K, Sumaru K, Edahiro J, Ooshima Y, Sugiura S, Takagi T, Kanamori T.  Stepwise assembly of micropatterned co-cultures using photoresponsive culture surfaces and its application to hepatic tissue arrays  Biotechnol Bioeng  2009  103(3):552-61.  PubMed ID: 19170244   DOI: 10.1002/bit.22253
18478  Ikebuchi Y, Takada T, Ito K, Yoshikado T, Anzai N, Kanai Y, Suzuki H.  Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4  Hepatol Res  2009  39(11):1091-107  PubMed ID: 19674157   DOI: 10.1111/j.1872-034X.2009.00544.x
18850  Abe H, Ochi H, Maekawa T, Hatakeyama T, Tsuge M, Kitamura S, Kimura T, Miki D, Mitsui F, Hiraga N, Imamura M, Fujimoto Y, Takahashi S, Nakamura Y, Kumada H, Chayama K.  Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection  Hepatol Res  2009  39(12):1159-68  PubMed ID: 19788695   DOI: 10.1111/j.1872-034X.2009.00566.x
8705  Hattori N, Suzuki T, Jinno S, Okeya H, Ishikawa A, Kondo C, Hayashi T, Ito M, Kanamori T, Kawai T, Noguchi T.  Methyl methacrylate activates the Gsta1 promoter.  J. Dent. Res.  2008  87:1117-21  PubMed ID: 19029078   DOI: 10.1177/154405910808701214
8720  Mori R, Sakai Y, Nakazawa K.  Micropatterned organoid culture of rat hepatocytes and HepG2 cells.  J. Biosci. Bioeng.  2008  106:237-42  PubMed ID: 18929998   DOI: 10.1263/jbb.106.237
8765  Saigo K, Yoshida K, Ikeda R, Sakamoto Y, Murakami Y, Urashima T, Asano T, Kenmochi T, Inoue I.  Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.  Hum. Mutat.  2008  29:703-8  PubMed ID: 18320596   DOI: 10.1002/humu.20701
8786  Tamura T, Sakai Y, Nakazawa K.  Two-dimensional microarray of HepG2 spheroids using collagen/polyethylene glycol micropatterned chip.  J Mater Sci Mater Med  2008  19:2071-7  PubMed ID: 17968500   DOI: 10.1007/s10856-007-3305-1
18671  Shibata A, Nakagawa K, Sookwong P, Tsuduki T, Tomita S, Shirakawa H, Komai M, Miyazawa T.  Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha  J Nutr  2008  138(11):2136-42  PubMed ID: 18936210   DOI: 10.3945/jn.108.093237
19048  Tonooka K, Kabashima T, Shibata T, Tang C, Yu Z, Kai M.  Facile assay of telomerase activity utilizing a DNA-detectable chemiluminogenic reagent  Anal Sci  2008  24(4):471-5  PubMed ID: 18403837   DOI: 10.2116/analsci.24.471
8969  Li RS, Nakagawa Y, Liu YJ, Fujisawa Y, Sai S, Nakanishi T, Chapman KE, Seckl JR, Ohzeki T.  Growth hormone inhibits the 11 beta-Hydroxysteroid dehydrogenase type 1 gene promoter activity via insulin-like growth factor I in HepG2 cells  Horm Metab Res  2008  40(4):286-8  PubMed ID: 18548388   DOI: 10.1055/s-2008-1058076
12797  Yoshinari K, Ueda R, Kusano K, Yoshimura T, Nagata K, Yamazoe Y.  Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements  Biochem Pharmacol  2008  76(1):139-45  PubMed ID: 18502397   DOI: 10.1016/j.bcp.2008.04.005
13723    Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy  J Exp Ther Oncol  2008  7(2):153-67  PubMed ID: 18771089  
14931  Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y.  The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma  Lab Invest  2008  88(8):873-82  PubMed ID: 18591938   DOI: 10.1038/labinvest.2008.52
18984  Adachi T, Nakagawa H, Chung I, Hagiya Y, Hoshijima K, Noguchi N, Kuo MT, Ishikawa T.  Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress  J Exp Ther Oncol  2007  6(4):335-48  PubMed ID: 18038766  
19110  Takeba Y, Kumai T, Matsumoto N, Nakaya S, Tsuzuki Y, Yanagida Y, Kobayashi S.  Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis  J Pharmacol Sci  2007  104(3):232-42  PubMed ID: 17609585   DOI: 10.1254/jphs.fp0070442
8860  Horiuchi S, Aoyama Y.  Systematic lactose-functionalization of amphiphilic octaamine macrocycle as a gene carrier. Optimization of the charge, size, toxicity, and receptor factors for hepatocyte targeting.  J Control Release  2006  116:107-14  PubMed ID: 16905218   DOI: 10.1016/j.jconrel.2006.07.004
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294   DOI: 10.1093/jb/mvi177
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879   DOI: 10.1093/jb/mvi003
3407  Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi  Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.  Am J Physiol Endocrinol Metab  2005  288:E1101-9  PubMed ID: 15671080   DOI: 10.1152/ajpendo.00502.2004
14325  Sugatani J, Sueyoshi T, Negishi M, Miwa M.  Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor  Methods Enzymol  2005  400:92-104  PubMed ID: 16399345   DOI: 10.1016/S0076-6879(05)00006-6
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424   DOI: 10.1074/jbc.M401881200
9172  Harada K, Ohba K, Ozaki S, Isse K, Hirayama T, Wada A, Nakanuma Y.  Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree.  Hepatology  2004  40:925-32  PubMed ID: 15382127   DOI: 10.1002/hep.20379
12842  Sakai Y, Fukuda O, Choi SH, Sakoda A.  Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity  Altern Lab Anim  2004  32 Suppl 1A:99-103  PubMed ID: 23577440   DOI: 10.1177/026119290403201s15
12844  Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.  The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics  Biochem Pharmacol  2004  67(5):989-1000  PubMed ID: 15104253   DOI: 10.1016/j.bcp.2003.11.002
12845  Choi S, Nishikawa M, Sakoda A, Sakai Y.  Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity  Toxicol In Vitro  2004  18(3):393-402  PubMed ID: 15046787   DOI: 10.1016/j.tiv.2003.09.010
3793  Yoshida S, Honda A, Matsuzaki Y, Fukushima S, Tanaka N, Takagiwa A, Fujimoto Y, Miyazaki H, Salen G.  Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.  Steroids  2003  68(1):73-83  PubMed ID: 12475725   DOI: 10.1016/s0039-128x(02)00117-4
3794  Sakai Y, Fukuda O, Choi SH, Sakoda A.  Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.  J Artif Organs  2003  6(4):273-81  PubMed ID: 14691670   DOI: 10.1007/s10047-003-0238-4
14329  Hata K, Hori K, Ogasawara H, Takahashi S.  Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene  Toxicol Lett  2003  143(1):1-7  PubMed ID: 12697374   DOI: 10.1016/s0378-4274(03)00092-4
9400  Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S.  Identification and characterization of the human long form of Sox5 (L-SOX5) gene.  Gene  2002  298:59-68  PubMed ID: 12406576   DOI: 10.1016/s0378-1119(02)00927-7
3787  Mikiko Shimizu, Hiro-omi Tamura  Identification and Localization of Two Hydroxysteroid Sulfotransferases in the Human Brain  Journal of Health Science  2002  48:467-472    DOI: 10.1248/jhs.48.467
3773  Hirano R, Igarashi O, Kondo K, Itakura H, Matsumoto A.  Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.  Lipids  2001  36(4):401-6  PubMed ID: 11383693   DOI: 10.1007/s11745-001-0735-3
6400  Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.  A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.  J Orthop Sci  2001  6(3):269-75  PubMed ID: 11484122   DOI: 10.1007/s007760100046

トップへページトップへ
利用者成果(日)



戻る 戻る 理研トップページへ