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細胞番号 : 細胞名
RCB1648 : Hep G2  update : 2024/09/19
細胞特性(Comment:英)Human cell line derived from hepatoblastoma. Secretes several products such as albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 85011430 prior to order. Information
細胞特性(日)ヒト肝芽腫由来細胞株。albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin, plasminogenなどを分泌。ECACC由来株。使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、ECACC 85011430 を必ずご参照ください。Hep G2細胞の由来について
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85011430 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)1) 基礎的研究につきましては、使用制限はありません。しかし、使用条件等がECACCによって随時変更となる可能性があるので、購入前に、ECA85011430 を必ず参照すること。2) 商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 2000
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Male
15 years
採取組織 liver
病名 hepatocyte carcinoma
細胞分類 cancer
入手歴 overseas, Dr.Knowles (Wistar Institute, Ohiladelphoa) -> ECACC -> RIKEN Cell Bank
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0027
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS + 0.1mM NEAA
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 4-8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
ウィルス(HBV) (-)
ウィルス(HCV) (-)
アイソザイム検査 LD, NP
染色体検査 51-53(50) : 51(12).52(22),53(16)
個体識別検査 OK
文献情報 Reference(英) 5件
Reference(日) 1件
利用者成果(英) 162件
利用者成果(日) 0件

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Reference(英)
11987  Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles  Hep G2 is a hepatoblastoma-derived cell line  Hum Pathol  2009  40(10):1512-5  PubMed ID: 19751877   DOI: 10.1016/j.humpath.2009.07.003
1156  Darlington GJ, Kelly JH, Buffone GJ.  Growth and hepatospecific gene expression of human hepatoma cells in a defined medium  In Vitro Cell Dev Biol  1987  23(5):349-54.  PubMed ID: 3034851   DOI: 10.1007/BF02620991
1155  Knowles, B B, Howe, C C, Aden, D P  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.  Science  1980  209:497-9  PubMed ID: 6248960   DOI: 10.1126/science.6248960
4984  Diamond L1, Kruszewski F, Aden DP, Knowles BB, Baird WM.  Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.  Carcinogenesis  1980  1(10):871-5  PubMed ID: 11219860   DOI: 10.1093/carcin/1.10.871
465  Aden, D P, Fogel A, Plotkin S, Damjanov I, Knowles, B B  Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.  Nature  1979  282:615-6  PubMed ID: 233137   DOI: 10.1038/282615a0

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Reference(日)
1707  堀内龍也  ヒト : Hep G2  生体の科学  1992  43:383-384   

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利用者成果(英)
21548  Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.  An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.  J Pharmacol Sci  2024  154(1):37-46  PubMed ID: 38081682   DOI: 10.1016/j.jphs.2023.11.005
21661  Katoh M, Fujii T, Tabuchi Y, Shimizu T, Sakai H.  Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.  J Physiol Sci  2024  74(1):23  PubMed ID: 38561668   DOI: 10.1186/s12576-024-00914-7
21904  Negoro R, Ouchi A, Deguchi S, Takayama K, Fujita T.  Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.  Biol Pharm Bull  2024  47(8):1422-1428  PubMed ID: 39111864   DOI: 10.1248/bpb.b24-00202
22004  Urakawa D, Shioiridani Y, Igata S, Hou DX, Sakao K.  Comparative Analysis of Acetylated Flavonoids' Chemopreventive Effects in Different Cancer Cell Lines  Int J Mol Sci  2024  25(14):7689.  PubMed ID: 39062932   DOI: 10.3390/ijms25147689
22095  Toma T, Miyakawa N, Arakaki Y, Watanabe T, Nakahara R, Ali TFS, Biswas T, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.  An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models.  Diabetologia  2024  67(11):2568-2584  PubMed ID: 39251430   DOI: 10.1007/s00125-024-06260-y
19558  Kurawaka M, Sasaki N, Yamazaki Y, Shimura F.  Near-Physiological Concentrations of Extracellular Pyruvate Stimulated Glucose Utilization along with Triglyceride Accumulation and Mitochondrial Activity in HepG2 Cells  J Nutr Sci Vitaminol (Tokyo)  2023  69(5):314-325  PubMed ID: 37940572   DOI: 10.3177/jnsv.69.314
19640  Sakao K, Saruwatari H, Minami S, Hou DX.  Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells  Int J Mol Sci  2023  24(23):16652  PubMed ID: 38068974   DOI: 10.3390/ijms242316652
19644  Nakamura M, Urakawa D, He Z, Akagi I, Hou DX, Sakao K.  Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II)  Int J Mol Sci  2023  24(24):17457  PubMed ID: 38139286   DOI: 10.3390/ijms242417457
19989  Kodama S, Matsumoto S, Takamura Y, Fujihara M, Watanabe M, Ono A, Kakuta H.  Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha  Toxicol Lett  2023  15:373:76-83.  PubMed ID: 36368620   DOI: 10.1016/j.toxlet.2022.11.003
21179  Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.  Lysine long-chain fatty acylation regulates the TEAD transcription factor.  Cell Rep  2023  112388  PubMed ID: 37060904   DOI: 10.1016/j.celrep.2023.112388
21481  Nagatomo A, Kohno M, Kawakami H, Manse Y, Morikawa T.  Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver.  J Nat Med  2023    PubMed ID: 37973705   DOI: 10.1007/s11418-023-01756-0
22032  Shizu R, Otsuka Y, Ishii C, Ezaki K, Yoshinari K.  PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers.  Int J Mol Sci  2023  24(4)  PubMed ID: 36835365   DOI: 10.3390/ijms24043953
17664  Matsumura M, Murakami M, Funaba M.  Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family  Cell Biochem Funct   2022  ;40(7):742-749  PubMed ID: 36062805   DOI: 10.1002/cbf.3739
17682  Okumura M, Iwakiri T, Yoshikawa N, Nagatomo T, Ayabe T, Tsuneyoshi I, Ikeda R.  Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells  Int J Mol Sci  2022  23(16):9108  PubMed ID: 36012373   DOI: 10.3390/ijms23169108
20482  Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.  Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.  Int J Oncol  2022  60(1)  PubMed ID: 34913069   DOI: 10.3892/ijo.2021.5294
20514  Takezawa T, Uzu M.  HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.  J Toxicol Sci  2022  47(1):39-50  PubMed ID: 34987140   DOI: 10.2131/jts.47.39
20608  Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.  Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.  J Nat Med  2022    PubMed ID: 35292883   DOI: 10.1007/s11418-022-01614-5
20639  Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.  Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.  Oncol Rep  2022  47(4)  PubMed ID: 35169858   DOI: 10.3892/or.2022.8282
20691  Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.  A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.  Nat Commun  2022  13(1):2533  PubMed ID: 35534485   DOI: 10.1038/s41467-022-30153-6
16451  Kitano H, Kawabe Y, Kamihira M.  HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions  Cells  2022  11(7):1194  PubMed ID: 35406758   DOI: 10.3390/cells11071194
16644  Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.  Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System  Cells  2022  11(10):1677  PubMed ID: 35626714   DOI: 10.3390/cells11101677
20752  Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.  Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.  J Toxicol Sci  2022  47(6):249-255  PubMed ID: 35650141   DOI: 10.2131/jts.47.249
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20840  Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.  Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.  Sci Rep  2022  12(1):14520  PubMed ID: 36008442   DOI: 10.1038/s41598-022-18572-3
20842  Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.  Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.  J Oral Microbiol  2022  14(1):2105013  PubMed ID: 35937899   DOI: 10.1080/20002297.2022.2105013
20911  Imanishi S, Nagata S, Fujita T, Fujii H.  Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.  Int J Exp Pathol  2022    PubMed ID: 36153641   DOI: 10.1111/iep.12457
20926  Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.  Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.  Redox Biol  2022  57:102514  PubMed ID: 36279630   DOI: 10.1016/j.redox.2022.102514
22034  Nagatomo A, Ninomiya K, Marumoto S, Sakai C, Watanabe S, Ishikawa W, Manse Y, Kikuchi T, Yamada T, Tanaka R, Muraoka O, Morikawa T.  A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells.  Int J Mol Sci  2022  23(21)  PubMed ID: 36361930   DOI: 10.3390/ijms232113141
13301  Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.  Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.  J Biomater Sci Polym Ed  2021  32(3):405-416  PubMed ID: 33074050   DOI: 10.1080/09205063.2020.1838045
13453  SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima  Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor  Drug Metabolism and Pharmacokinetics  2021    PubMed ID: 33515843   DOI: 10.1016/j.dmpk.2020.11.002
20006  Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.  Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.  Pharmaceutics  2021  13(1)  PubMed ID: 33430003   DOI: 10.3390/pharmaceutics13010078
20035  Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.  Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.  Glycoconj J  2021  38(1):45-54  PubMed ID: 33523362   DOI: 10.1007/s10719-020-09970-8
20110  Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.  Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.  J Biochem  2021    PubMed ID: 33844018   DOI: 10.1093/jb/mvab049
20136  El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.  MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33886022   DOI: 10.1245/s10434-021-09778-2
15116  Toshiaki TAKEZAWA  Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes  Nano Biomedicine  2021  13:1-7    DOI: 10.11344/nano.13.1
15515  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.  A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment  Cancers (Basel)  2021  13(16):3997  PubMed ID: 34439154   DOI: 10.3390/cancers13163997
16049  Endo A, Asayama S.  Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization  Pharmaceutics  2021  13(12):2084  PubMed ID: 34959365   DOI: 10.3390/pharmaceutics13122084
16135  Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.  A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals  Free Radic Biol Med  2021  163:297-305  PubMed ID: 33359688   DOI: 10.1016/j.freeradbiomed.2020.12.028
20621  Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.  Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.  J Toxicol Sci  2021  46(12):569-587  PubMed ID: 34853243   DOI: 10.2131/jts.46.569
16527  Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.  Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach  Tumour Biol  2021  43(1):309-325  PubMed ID: 34897107   DOI: 10.3233/TUB-211507
16876  Takemura A, Gong S, Sato T, Kawaguchi M, Sekine S, Kazuki Y, Horie T, Ito K.  Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells  J Pharm Sci  2021  110(9):3306-3312  PubMed ID: 34097978   DOI: 10.1016/j.xphs.2021.06.001
16984  Kawase A, Hirosoko M, Sugihara Y, Koyama Y, Fukae A, Shimada H, Iwaki M.  NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells  Pharmaceuticals (Basel)  2021  14(3):239.  PubMed ID: 33800412   DOI: 10.3390/ph14030239
22037  Tsuji T, Morita SY, Nakamura Y, Ikeda Y, Kambe T, Terada T.  Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth.  Sci Rep  2021  11(1):2731  PubMed ID: 33526799   DOI: 10.1038/s41598-021-81733-3
11062  Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto  Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation  Journal of Molecular Liquids  2020  299:112166    DOI: 10.1016/j.molliq.2019.112166
12988  Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.  Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.  Sci Rep  2020    PubMed ID: 32317652   DOI: 10.1038/s41598-020-63362-4
13110  Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.  Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.  J Biosci Bioeng  2020    PubMed ID: 32636145   DOI: 10.1016/j.jbiosc.2020.05.010
13491  Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai  Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide  Fundamental Toxicological Sciences  2020  7 :161-166    DOI: 10.2131/fts.7.161
14497  Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.  Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device  R Soc Open Sci  2020  7(7):200027  PubMed ID: 32874617   DOI: 10.1098/rsos.200027
14851  Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.  Protective Effects of Rice Peptide Oryza Peptide-P60 against Oxidative Injury through Activation of Nrf2 Signaling Pathway In Vitro and In Vivo  ACS Omega  2020  5(22):13096-13107  PubMed ID: 32548495   DOI: 10.1021/acsomega.0c01016
15192  Takagi K, Midorikawa Y, Takayama T, Abe H, Fujiwara K, Soma M, Nagase H, Miki T, Fukuda N.  Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells  Molecules  2020  25(12):2883  PubMed ID: 32585841   DOI: 10.3390/molecules25122883
16623  Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.  Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A  Anticancer Res  2020  40(1):161-168  PubMed ID: 31892564   DOI: 10.21873/anticanres.13937
16883  Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.  Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines  Toxicol In Vitro  2020  69:104999.  PubMed ID: 32949729   DOI: 10.1016/j.tiv.2020.104999
17874  Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.  Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells  J Histochem Cytochem  2019  67(2):129-141  PubMed ID: 30303767   DOI: 10.1369/0022155418804507
11540  Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.  A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.  Virol. J.  2019    PubMed ID: 31046787   DOI: 10.1186/s12985-019-1169-x
11585  Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.  Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.  Medicines (Basel)  2019    PubMed ID: 31163644   DOI: 10.3390/medicines6020063
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
10371  Akito Endo, Shoichiro Asayama  Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery  Journal of Minerals and Materials Characterization and Engineering  2019  7:94802,8    DOI: 10.4236/jmmce.2019.75016
10854  Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki  PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces  Sensors and Actuators B: Chemical  2019  287:486-495    DOI: 10.1016/j.snb.2019.02.067
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920   DOI: 10.18433/jpps30444
12437  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.  Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry  PLoS One  2019  14(3):e0214000  PubMed ID: 30875389   DOI: 10.1371/journal.pone.0214000
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