| User's Publication |
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21179
Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.
Lysine long-chain fatty acylation regulates the TEAD transcription factor.
Cell Rep
2023
112388
PubMed ID: 37060904
DOI: 10.1016/j.celrep.2023.112388
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17664
Matsumura M, Murakami M, Funaba M.
Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family
Cell Biochem Funct
2022
;40(7):742-749
PubMed ID: 36062805
DOI: 10.1002/cbf.3739
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17682
Okumura M, Iwakiri T, Yoshikawa N, Nagatomo T, Ayabe T, Tsuneyoshi I, Ikeda R.
Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells
Int J Mol Sci
2022
23(16):9108
PubMed ID: 36012373
DOI: 10.3390/ijms23169108
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20482
Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.
Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.
Int J Oncol
2022
60(1)
PubMed ID: 34913069
DOI: 10.3892/ijo.2021.5294
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20514
Takezawa T, Uzu M.
HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.
J Toxicol Sci
2022
47(1):39-50
PubMed ID: 34987140
DOI: 10.2131/jts.47.39
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20608
Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
J Nat Med
2022
PubMed ID: 35292883
DOI: 10.1007/s11418-022-01614-5
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20639
Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.
Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.
Oncol Rep
2022
47(4)
PubMed ID: 35169858
DOI: 10.3892/or.2022.8282
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20691
Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.
A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.
Nat Commun
2022
13(1):2533
PubMed ID: 35534485
DOI: 10.1038/s41467-022-30153-6
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16451
Kitano H, Kawabe Y, Kamihira M.
HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions
Cells
2022
11(7):1194
PubMed ID: 35406758
DOI: 10.3390/cells11071194
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16644
Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.
Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System
Cells
2022
11(10):1677
PubMed ID: 35626714
DOI: 10.3390/cells11101677
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20752
Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.
Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.
J Toxicol Sci
2022
47(6):249-255
PubMed ID: 35650141
DOI: 10.2131/jts.47.249
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20799
Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.
Nat Commun
2022
13(1):4355
PubMed ID: 35906200
DOI: 10.1038/s41467-022-32034-4
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20840
Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.
Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.
Sci Rep
2022
12(1):14520
PubMed ID: 36008442
DOI: 10.1038/s41598-022-18572-3
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20911
Imanishi S, Nagata S, Fujita T, Fujii H.
Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.
Int J Exp Pathol
2022
PubMed ID: 36153641
DOI: 10.1111/iep.12457
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20926
Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biol
2022
57:102514
PubMed ID: 36279630
DOI: 10.1016/j.redox.2022.102514
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13301
Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.
J Biomater Sci Polym Ed
2021
32(3):405-416
PubMed ID: 33074050
DOI: 10.1080/09205063.2020.1838045
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13453
SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor
Drug Metabolism and Pharmacokinetics
2021
PubMed ID: 33515843
DOI: 10.1016/j.dmpk.2020.11.002
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20006
Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.
Pharmaceutics
2021
13(1)
PubMed ID: 33430003
DOI: 10.3390/pharmaceutics13010078
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20035
Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.
Glycoconj J
2021
38(1):45-54
PubMed ID: 33523362
DOI: 10.1007/s10719-020-09970-8
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20110
Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.
Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.
J Biochem
2021
PubMed ID: 33844018
DOI: 10.1093/jb/mvab049
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20136
El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.
Ann Surg Oncol
2021
PubMed ID: 33886022
DOI: 10.1245/s10434-021-09778-2
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15116
Toshiaki TAKEZAWA
Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes
Nano Biomedicine
2021
13:1-7
DOI: 10.11344/nano.13.1
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15515
Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.
A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment
Cancers (Basel)
2021
13(16):3997
PubMed ID: 34439154
DOI: 10.3390/cancers13163997
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16049
Endo A, Asayama S.
Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization
Pharmaceutics
2021
13(12):2084
PubMed ID: 34959365
DOI: 10.3390/pharmaceutics13122084
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16135
Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.
A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals
Free Radic Biol Med
2021
163:297-305
PubMed ID: 33359688
DOI: 10.1016/j.freeradbiomed.2020.12.028
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20621
Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.
J Toxicol Sci
2021
46(12):569-587
PubMed ID: 34853243
DOI: 10.2131/jts.46.569
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16527
Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.
Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach
Tumour Biol
2021
43(1):309-325
PubMed ID: 34897107
DOI: 10.3233/TUB-211507
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16876
Takemura A, Gong S, Sato T, Kawaguchi M, Sekine S, Kazuki Y, Horie T, Ito K.
Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells
J Pharm Sci
2021
110(9):3306-3312
PubMed ID: 34097978
DOI: 10.1016/j.xphs.2021.06.001
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16984
Kawase A, Hirosoko M, Sugihara Y, Koyama Y, Fukae A, Shimada H, Iwaki M.
NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells
Pharmaceuticals (Basel)
2021
14(3):239.
PubMed ID: 33800412
DOI: 10.3390/ph14030239
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11062
Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto
Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation
Journal of Molecular Liquids
2020
299:112166
DOI: 10.1016/j.molliq.2019.112166
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12988
Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.
Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.
Sci Rep
2020
PubMed ID: 32317652
DOI: 10.1038/s41598-020-63362-4
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13110
Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.
Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.
J Biosci Bioeng
2020
PubMed ID: 32636145
DOI: 10.1016/j.jbiosc.2020.05.010
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13491
Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide
Fundamental Toxicological Sciences
2020
7 :161-166
DOI: 10.2131/fts.7.161
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14497
Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.
Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
R Soc Open Sci
2020
7(7):200027
PubMed ID: 32874617
DOI: 10.1098/rsos.200027
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14851
Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.
Protective Effects of Rice Peptide Oryza Peptide-P60 against Oxidative Injury through Activation of Nrf2 Signaling Pathway In Vitro and In Vivo
ACS Omega
2020
5(22):13096-13107
PubMed ID: 32548495
DOI: 10.1021/acsomega.0c01016
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15192
Takagi K, Midorikawa Y, Takayama T, Abe H, Fujiwara K, Soma M, Nagase H, Miki T, Fukuda N.
Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells
Molecules
2020
25(12):2883
PubMed ID: 32585841
DOI: 10.3390/molecules25122883
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16623
Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.
Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A
Anticancer Res
2020
40(1):161-168
PubMed ID: 31892564
DOI: 10.21873/anticanres.13937
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16883
Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.
Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines
Toxicol In Vitro
2020
69:104999.
PubMed ID: 32949729
DOI: 10.1016/j.tiv.2020.104999
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17874
Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.
Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells
J Histochem Cytochem
2019
67(2):129-141
PubMed ID: 30303767
DOI: 10.1369/0022155418804507
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11540
Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Virol. J.
2019
PubMed ID: 31046787
DOI: 10.1186/s12985-019-1169-x
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11585
Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.
Medicines (Basel)
2019
PubMed ID: 31163644
DOI: 10.3390/medicines6020063
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9810
Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
DOI: 10.1080/15592324.2019.1644594
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10371
Akito Endo, Shoichiro Asayama
Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery
Journal of Minerals and Materials Characterization and Engineering
2019
7:94802,8
DOI: 10.4236/jmmce.2019.75016
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10854
Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki
PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces
Sensors and Actuators B: Chemical
2019
287:486-495
DOI: 10.1016/j.snb.2019.02.067
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11906
Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
J Pharm Pharm Sci
2019
PubMed ID: 31804920
DOI: 10.18433/jpps30444
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12437
Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
2019
14(3):e0214000
PubMed ID: 30875389
DOI: 10.1371/journal.pone.0214000
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14893
Morikawa T, Nagatomo A, Oka T, Miki Y, Taira N, Shibano-Kitahara M, Hori Y, Muraoka O, Ninomiya K.
Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism
Int J Mol Sci
2019
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PubMed ID: 31847420
DOI: 10.3390/ijms20246322
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4214
Matsumura K, Imai H, Go Y, Kusuhara M, Yamaguchi K, Shirai T, Ohshima K.
Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor.
Gene
2018
PubMed ID: 30096459
DOI: 10.1016/j.gene.2018.08.033
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4216
Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.
Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.
Cell Commun. Signal
2018
PubMed ID: 30180849
DOI: 10.1186/s12964-018-0262-x
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4222
Miyamoto D, Hara T, Hyakutake A, Nakazawa K.
Changes in HepG2 spheroid behavior induced by differences in the gap distance between spheroids in a micropatterned culture system.
J. Biosci. Bioeng.
2018
PubMed ID: 29352710
DOI: 10.1016/j.jbiosc.2017.12.013
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4340
Nagatome M, Kondo Y, Kadowaki D, Saishyo Y, Irikura M, Irie T, Ishitsuka Y.
Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine.
Heliyon
2018
PubMed ID: 29560444
DOI: 10.1016/j.heliyon.2018.e00521
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9973
Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.
Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.
J Clin Biochem Nutr
2017
60:115-120
PubMed ID: 28366990
DOI: 10.3164/jcbn.16-44
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10185
Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.
Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.
Br. J. Cancer
2017
116:1046-1056
PubMed ID: 28291773
DOI: 10.1038/bjc.2017.65
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10595
Uemura T, Takasaka T, Igarashi K, Ikegaya H.
Spermine oxidase promotes bile canalicular lumen formation through acrolein production.
Sci Rep
2017
7:14841
PubMed ID: 29093526
DOI: 10.1038/s41598-017-14929-1
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12220
Shoichiro Asayama, Mizuki Sakata, Hiroyoshi Kawakami
Structure-activity relationship between Zn 2+-chelated alkylated poly(1-vinylimidazole) and gene transfection
J Inorg Biochem
2017
173:120-125
PubMed ID: 28511062
DOI: 10.1016/j.jinorgbio.2017.05.007
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14592
Kusama K, Okamoto Y, Saito K, Kasahara T, Murata T, Ueno Y, Kobayashi Y, Kamada Y, Miyoshi E.
Reevaluation of Pholiota squarrosa lectin-reactive haptoglobin as a pancreatic cancer biomarker using an improved ELISA system
Glycoconj J
2017
34(4):537-544
PubMed ID: 28455724
DOI: 10.1007/s10719-017-9772-9
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14609
Enomoto J, Kageyama T, Osaki T, Bonalumi F, Marchese F, Gautieri A, Bianchi E, Dubini G, Arrigoni C, Moretti M, Fukuda J.
Catch-and-Release of Target Cells Using Aptamer-Conjug
Sci Rep
2017
7:43375
PubMed ID: 28266533
DOI: 10.1038/srep43375
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9576
Sugai S, Yoshikawa T, Iwama T, Tsuchiya N, Ueda N, Fujinami N, Shimomura M, Zhang R, Kaneko S, Uemura Y, Nakatsura T.
Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate.
Int. J. Oncol.
2016
48:1794-804
PubMed ID: 26936487
DOI: 10.3892/ijo.2016.3403
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9946
Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.
Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator.
J Toxicol Sci
2016
41:775-781
PubMed ID: 27853106
DOI: 10.2131/jts.41.775
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10020
Moriyama K, Naito S, Wakabayashi R, Goto M, Kamiya N.
Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation.
Biotechnol J
2016
11:1452-1460
PubMed ID: 27617786
DOI: 10.1002/biot.201600087
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4039
Oshikata-Miyazaki A, Takezawa T.
Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber.
Cytotechnology
2016
68(5):1801-11
PubMed ID: 26660096
DOI: 10.1007/s10616-015-9934-1
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12685
Takei T, Kitazono J, Tanaka S, Nishimata H, Yoshida M.
Necrotic regions are absent in fiber-shaped cell aggregates, approximately 100 μm in diameter
Artif Cells Nanomed Biotechnol
2016
44(1):62-5
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DOI: 10.3109/21691401.2014.909824
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12946
Yun YS, Tajima M, Takahashi S, Takahashi Y, Umemura M, Nakano H, Park HS, Inoue H.
Two Alkaloids from Bulbs of Lycoris sanguinea M AXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB
Phytother Res
2016
30(10):1689-1695
PubMed ID: 27388056
DOI: 10.1002/ptr.5676
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7373
Takei T, Aokawa R, Shigemitsu T, Kawakami K, Yoshida M.
Fabrication of uniformly cell-laden porous scaffolds using a gas-in-liquid templating technique.
J. Biosci. Bioeng.
2015
120:577-81
PubMed ID: 25912452
DOI: 10.1016/j.jbiosc.2015.03.017
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7456
Okina Y, Takeuchi F, Yokomichi T, Takada Y, Kataoka T.
Cardenolide aglycones inhibit tumor necrosis factor α-induced expression of intercellular adhesion molecule-1 at the translation step by blocking Na⁺/K⁺-ATPase
Biol. Pharm. Bull.
2015
38:39-47
PubMed ID: 25744456
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7501
Lai YT, Sato M, Ohta S, Akamatsu K, Nakao S, Sakai Y, Ito T.
Preparation of uniform-sized hemoglobin-albumin microspheres as oxygen carriers by Shirasu porous glass membrane emulsification technique.
Colloids Surf B Biointerfaces
2015
127:1-7
PubMed ID: 25635614
DOI: 10.1016/j.colsurfb.2015.01.018
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5372
Nakajima Y, Kanno T, Nagaya T, Kuribayashi K, Nakano T, Gotoh A, Nishizaki T.
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.
Cell Physiol Biochem
2015
35(1):51-60
PubMed ID: 25547995
DOI: 10.1159/000369674
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14967
Higashi T, Hayashi H, Ishimoto T, Takeyama H, Kaida T, Arima K, Taki K, Sakamoto K, Kuroki H, Okabe H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H.
miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells
Br J Cancer
2015
113(2):252-8
PubMed ID: 26125451
DOI: 10.1038/bjc.2015.170
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15231
Motoyama K, Hirai Y, Nishiyama R, Maeda Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Era T, Arima H.
Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells
Beilstein J Org Chem
2015
11:2079-86
PubMed ID: 26664628
DOI: 10.3762/bjoc.11.224
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5589
Ozeki M, Kato H, Tamaki K.
Development of a novel miniplex DNA identification system for the Japanese population
Leg Med (Tokyo)
2015
17(3):205-9
PubMed ID: 25596639
DOI: 10.1016/j.legalmed.2014.12.007
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10275
Nobumasa Hara, Tomoko Shibata, Harumi Osago, Kazuo Yamada, Mikako Tsuchiya
Formation of [nicotinamide-²H₃]NAD⁺ From [²H₄]nicotinamide and [²H₄]nicotinic Acid in Human HepG2N Cells and Involvement of ²H/¹H Exchange at the Redox Site of NAD⁺/NADH
J Nutr Sci Vitaminol (Tokyo)
2014
60(1):17-21
PubMed ID: 24759255
DOI: 10.3177/jnsv.60.17
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10281
Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa
Comparison of the Effects of Curcumin and Curcumin Glucuronide in Human Hepatocellular Carcinoma HepG2 Cells
Food Chem
2014
151:126-32
PubMed ID: 24423511
DOI: 10.1016/j.foodchem.2013.11.021
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14194
Naoki Tanigawa, Sachiko Yano, Akira Higashibata, Yoshikazu Tsuchiya, Haruna Tanii, Noboru Ando, Koji Kubota, Mutsumu Nagase
Development and Validation of a Closed Chamber for Cell Culture Experiments in Space
Biological Sciences in Space
2014
28:1-5
DOI: 10.2187/bss.28.1
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17095
Mori M, Tiang G, Higuchi K.
AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform
Amyloid
2014
21(1):1-8
PubMed ID: 24228751
DOI: 10.3109/13506129.2013.852529
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5844
Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.
1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.
Pharmacology
2013
91(5-6):339-45
PubMed ID: 23817168
DOI: 10.1159/000351747
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12867
Hanada S, Fujioka K, Futamura Y, Manabe N, Hoshino A, Yamamoto K.
Evaluation of anti-inflammatory drug-conjugated silicon quantum dots: their cytotoxicity and biological effect
Int J Mol Sci
2013
14(1):1323-34
PubMed ID: 23306154
DOI: 10.3390/ijms14011323
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15922
Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.
Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers
Proc Natl Acad Sci U S A
2013
110(6):2105-10
PubMed ID: 23345451
DOI: 10.1073/pnas.1214233110
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15936
Kondo Y, Ishitsuka Y, Kadowaki D, Fukumoto Y, Miyamoto Y, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T.
Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation
J Pharm Pharmacol
2013
65(3):390-401
PubMed ID: 23356848
DOI: 10.1111/j.2042-7158.2012.01602.x
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16610
Abiko Y, Kumagai Y.
Interaction of Keap1 modified by 2-tert-butyl-1,4-benzoquinone with GSH: evidence for S-transarylatio
Chem Res Toxicol
2013
26(7):1080-7
PubMed ID: 23718696
DOI: 10.1021/tx400085h
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7683
Fujii T, Minagawa T, Shimizu T, Takeguchi N, Sakai H.
Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells.
J Physiol Sci
2012
62:53-8
PubMed ID: 21932081
DOI: 10.1007/s12576-011-0176-5
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12539
Kawano Y, Nagata M, Kohno T, Ichimiya A, Iwakiri T, Okumura M, Arimori K.
Caffeine increases the antitumor effect of Cisplatin in human hepatocellular carcinoma cells
Biol Pharm Bull
2012
35(3):400-7
PubMed ID: 22382328
DOI: 10.1248/bpb.35.400
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12727
Tamura K, Kanno T, Fujita Y, Gotoh A, Nakano T, Nishizaki T.
A(2a) adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-X(L) expression and upregulating Bid expression
J Cell Biochem
2012
113(5):1766-75.
PubMed ID: 22213163
DOI: 10.1002/jcb.24048
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7642
Tagaya M, Yamazaki T, Tsuya D, Sugimoto Y, Hanagata N, Ikoma T.
Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion.
Macromol Biosci
2011
11:1586-93
PubMed ID: 22052565
DOI: 10.1002/mabi.201100182
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7988
Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J.
Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells.
J. Agric. Food Chem.
2011
59:1470-6
PubMed ID: 21226458
DOI: 10.1021/jf103820b
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12747
Yaguchi T, Nakano T, Gotoh A, Nishizaki T.
Adenosine promotes GATA-2-regulated p53 gene transcription to induce HepG2 cell apoptosis
Cell Physiol Biochem
2011
28(4):761-70
PubMed ID: 22178888
DOI: 10.1159/000335770
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13678
Masuda M, Shimomura M, Kobayashi K, Kojima S, Nakatsura T.
Growth inhibition by NVP-BEZ235, a dual PI3K/mTOR inhibitor, in hepatocellular carcinoma cell lines
Oncol Rep
2011
26(5):1273-9
PubMed ID: 21725613
DOI: 10.3892/or.2011.1370
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8211
Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.
Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.
J. Biosci. Bioeng.
2010
110:572-6
PubMed ID: 20591731
DOI: 10.1016/j.jbiosc.2010.05.013
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8234
Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.
Cell micropatterning inside a microchannel and assays under a stable concentration gradient.
J. Biosci. Bioeng.
2010
110:230-7
PubMed ID: 20547384
DOI: 10.1016/j.jbiosc.2010.02.001
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8237
Sakai Y, Yoshida S, Yoshiura Y, Mori R, Tamura T, Yahiro K, Mori H, Kanemura Y, Yamasaki M, Nakazawa K.
Effect of microwell chip structure on cell microsphere production of various animal cells.
J. Biosci. Bioeng.
2010
110:223-9
PubMed ID: 20547385
DOI: 10.1016/j.jbiosc.2010.01.021
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8454
Yang D, Yaguchi T, Lim CR, Ishizawa Y, Nakano T, Nishizaki T.
Tuning of apoptosis-mediator gene transcription in HepG2 human hepatoma cells through an adenosine signal.
Cancer Lett.
2010
291:225-9
PubMed ID: 19900759
DOI: 10.1016/j.canlet.2009.10.016
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12754
Yang D, Yaguchi T, Nakano T, Nishizaki T.
Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells
Cell Biol Toxicol
2010
26(4):319-30
PubMed ID: 20063052
DOI: 10.1007/s10565-009-9145-7
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12757
Sato W, Suzuki H, Sasaki T, Kumagai T, Sakaguchi S, Mizugaki M, Miyairi S, Yamazoe Y, Nagata K.
Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid
Drug Metab Pharmacokinet
2010
25(2):180-9
PubMed ID: 20460824
DOI: 10.2133/dmpk.25.180
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15367
Miki T, Iguchi M, Akiba K, Hosono M, Sobue T, Danbara H, Okada N.
Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes
Mol Microbiol
2010
77(4):855-72
PubMed ID: 20545857
DOI: 10.1111/j.1365-2958.2010.07248.x
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16392
Plessy C, Bertin N, Takahashi H, Simone R, Salimullah M, Lassmann T, Vitezic M, Severin J, Olivarius S, Lazarevic D, Hornig N, Orlando V, Bell I, Gao H, Dumais J, Kapranov P, Wang H, Davis CA, Gingeras TR, Kawai J, Daub CO, Hayashizaki Y, Gustincich S, Carninci P.
Linking promoters to functional transcripts in small samples with nanoCAGE and CAGEscan
Nat Methods
2010
7(7):528-34
PubMed ID: 20543846
DOI: 10.1038/nmeth.1470
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8705
Hattori N, Suzuki T, Jinno S, Okeya H, Ishikawa A, Kondo C, Hayashi T, Ito M, Kanamori T, Kawai T, Noguchi T.
Methyl methacrylate activates the Gsta1 promoter.
J. Dent. Res.
2008
87:1117-21
PubMed ID: 19029078
DOI: 10.1177/154405910808701214
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8720
Mori R, Sakai Y, Nakazawa K.
Micropatterned organoid culture of rat hepatocytes and HepG2 cells.
J. Biosci. Bioeng.
2008
106:237-42
PubMed ID: 18929998
DOI: 10.1263/jbb.106.237
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8765
Saigo K, Yoshida K, Ikeda R, Sakamoto Y, Murakami Y, Urashima T, Asano T, Kenmochi T, Inoue I.
Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.
Hum. Mutat.
2008
29:703-8
PubMed ID: 18320596
DOI: 10.1002/humu.20701
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8786
Tamura T, Sakai Y, Nakazawa K.
Two-dimensional microarray of HepG2 spheroids using collagen/polyethylene glycol micropatterned chip.
J Mater Sci Mater Med
2008
19:2071-7
PubMed ID: 17968500
DOI: 10.1007/s10856-007-3305-1
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12797
Yoshinari K, Ueda R, Kusano K, Yoshimura T, Nagata K, Yamazoe Y.
Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements
Biochem Pharmacol
2008
76(1):139-45
PubMed ID: 18502397
DOI: 10.1016/j.bcp.2008.04.005
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13723
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy
J Exp Ther Oncol
2008
7(2):153-67
PubMed ID: 18771089
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14931
Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y.
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
Lab Invest
2008
88(8):873-82
PubMed ID: 18591938
DOI: 10.1038/labinvest.2008.52
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8860
Horiuchi S, Aoyama Y.
Systematic lactose-functionalization of amphiphilic octaamine macrocycle as a gene carrier. Optimization of the charge, size, toxicity, and receptor factors for hepatocyte targeting.
J Control Release
2006
116:107-14
PubMed ID: 16905218
DOI: 10.1016/j.jconrel.2006.07.004
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
DOI: 10.1093/jb/mvi177
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
DOI: 10.1093/jb/mvi003
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3407
Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi
Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.
Am J Physiol Endocrinol Metab
2005
288:E1101-9
PubMed ID: 15671080
DOI: 10.1152/ajpendo.00502.2004
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14325
Sugatani J, Sueyoshi T, Negishi M, Miwa M.
Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor
Methods Enzymol
2005
400:92-104
PubMed ID: 16399345
DOI: 10.1016/S0076-6879(05)00006-6
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
DOI: 10.1074/jbc.M401881200
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9172
Harada K, Ohba K, Ozaki S, Isse K, Hirayama T, Wada A, Nakanuma Y.
Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree.
Hepatology
2004
40:925-32
PubMed ID: 15382127
DOI: 10.1002/hep.20379
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
DOI: 10.1177/026119290403201s15
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
DOI: 10.1016/j.bcp.2003.11.002
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12845
Choi S, Nishikawa M, Sakoda A, Sakai Y.
Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity
Toxicol In Vitro
2004
18(3):393-402
PubMed ID: 15046787
DOI: 10.1016/j.tiv.2003.09.010
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3793
Yoshida S, Honda A, Matsuzaki Y, Fukushima S, Tanaka N, Takagiwa A, Fujimoto Y, Miyazaki H, Salen G.
Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.
Steroids
2003
68(1):73-83
PubMed ID: 12475725
DOI: 10.1016/s0039-128x(02)00117-4
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
DOI: 10.1007/s10047-003-0238-4
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14329
Hata K, Hori K, Ogasawara H, Takahashi S.
Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene
Toxicol Lett
2003
143(1):1-7
PubMed ID: 12697374
DOI: 10.1016/s0378-4274(03)00092-4
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9400
Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S.
Identification and characterization of the human long form of Sox5 (L-SOX5) gene.
Gene
2002
298:59-68
PubMed ID: 12406576
DOI: 10.1016/s0378-1119(02)00927-7
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3787
Mikiko Shimizu, Hiro-omi Tamura
Identification and Localization of Two Hydroxysteroid Sulfotransferases in the Human Brain
Journal of Health Science
2002
48:467-472
DOI: 10.1248/jhs.48.467
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3773
Hirano R, Igarashi O, Kondo K, Itakura H, Matsumoto A.
Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.
Lipids
2001
36(4):401-6
PubMed ID: 11383693
DOI: 10.1007/s11745-001-0735-3
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6400
Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.
A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.
J Orthop Sci
2001
6(3):269-75
PubMed ID: 11484122
DOI: 10.1007/s007760100046
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