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Cell No. : Cell Name
RCB1648 : Hep G2  update : 2024/05/14
CommentHuman cell line derived from hepatoblastoma. Secretes several products such as albumin, alpha2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 85011430 prior to order. Information
Comment from the depositor
Terms and conditions1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85011430 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor ECACC
Year of deposit 2000
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 15 years
Tissue liver
Disease name hepatocyte carcinoma
Classification cancer
History overseas, Dr.Knowles (Wistar Institute, Ohiladelphoa) -> ECACC -> RIKEN Cell Bank
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0027
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 51-53(50) : 51(12).52(22),53(16)
STR(human) OK
Reference information Reference 5
User's Publication 148

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11987  Dolores López-Terrada, Sau Wai Cheung, Milton J Finegold, Barbara B Knowles  Hep G2 is a hepatoblastoma-derived cell line  Hum Pathol  2009  40(10):1512-5  PubMed ID: 19751877   DOI: 10.1016/j.humpath.2009.07.003
1156  Darlington GJ, Kelly JH, Buffone GJ.  Growth and hepatospecific gene expression of human hepatoma cells in a defined medium  In Vitro Cell Dev Biol  1987  23(5):349-54.  PubMed ID: 3034851   DOI: 10.1007/BF02620991
1155  Knowles, B B, Howe, C C, Aden, D P  Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.  Science  1980  209:497-9  PubMed ID: 6248960   DOI: 10.1126/science.6248960
4984  Diamond L1, Kruszewski F, Aden DP, Knowles BB, Baird WM.  Metabolic activation of benzo[a]pyrene by a human hepatoma cell line.  Carcinogenesis  1980  1(10):871-5  PubMed ID: 11219860   DOI: 10.1093/carcin/1.10.871
465  Aden, D P, Fogel A, Plotkin S, Damjanov I, Knowles, B B  Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line.  Nature  1979  282:615-6  PubMed ID: 233137   DOI: 10.1038/282615a0

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User's Publication
21548  Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.  An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.  J Pharmacol Sci  2024  154(1):37-46  PubMed ID: 38081682   DOI: 10.1016/j.jphs.2023.11.005
21661  Katoh M, Fujii T, Tabuchi Y, Shimizu T, Sakai H.  Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.  J Physiol Sci  2024  74(1):23  PubMed ID: 38561668   DOI: 10.1186/s12576-024-00914-7
19558  Kurawaka M, Sasaki N, Yamazaki Y, Shimura F.  Near-Physiological Concentrations of Extracellular Pyruvate Stimulated Glucose Utilization along with Triglyceride Accumulation and Mitochondrial Activity in HepG2 Cells  J Nutr Sci Vitaminol (Tokyo)  2023  69(5):314-325  PubMed ID: 37940572   DOI: 10.3177/jnsv.69.314
19640  Sakao K, Saruwatari H, Minami S, Hou DX.  Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells  Int J Mol Sci  2023  24(23):16652  PubMed ID: 38068974   DOI: 10.3390/ijms242316652
19644  Nakamura M, Urakawa D, He Z, Akagi I, Hou DX, Sakao K.  Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II)  Int J Mol Sci  2023  24(24):17457  PubMed ID: 38139286   DOI: 10.3390/ijms242417457
19989  Kodama S, Matsumoto S, Takamura Y, Fujihara M, Watanabe M, Ono A, Kakuta H.  Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha  Toxicol Lett  2023  15:373:76-83.  PubMed ID: 36368620   DOI: 10.1016/j.toxlet.2022.11.003
21179  Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.  Lysine long-chain fatty acylation regulates the TEAD transcription factor.  Cell Rep  2023  112388  PubMed ID: 37060904   DOI: 10.1016/j.celrep.2023.112388
21481  Nagatomo A, Kohno M, Kawakami H, Manse Y, Morikawa T.  Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver.  J Nat Med  2023    PubMed ID: 37973705   DOI: 10.1007/s11418-023-01756-0
17664  Matsumura M, Murakami M, Funaba M.  Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family  Cell Biochem Funct   2022  ;40(7):742-749  PubMed ID: 36062805   DOI: 10.1002/cbf.3739
17682  Okumura M, Iwakiri T, Yoshikawa N, Nagatomo T, Ayabe T, Tsuneyoshi I, Ikeda R.  Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells  Int J Mol Sci  2022  23(16):9108  PubMed ID: 36012373   DOI: 10.3390/ijms23169108
20482  Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.  Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.  Int J Oncol  2022  60(1)  PubMed ID: 34913069   DOI: 10.3892/ijo.2021.5294
20514  Takezawa T, Uzu M.  HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.  J Toxicol Sci  2022  47(1):39-50  PubMed ID: 34987140   DOI: 10.2131/jts.47.39
20608  Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.  Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.  J Nat Med  2022    PubMed ID: 35292883   DOI: 10.1007/s11418-022-01614-5
20639  Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.  Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.  Oncol Rep  2022  47(4)  PubMed ID: 35169858   DOI: 10.3892/or.2022.8282
20691  Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.  A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.  Nat Commun  2022  13(1):2533  PubMed ID: 35534485   DOI: 10.1038/s41467-022-30153-6
16451  Kitano H, Kawabe Y, Kamihira M.  HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions  Cells  2022  11(7):1194  PubMed ID: 35406758   DOI: 10.3390/cells11071194
16644  Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.  Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System  Cells  2022  11(10):1677  PubMed ID: 35626714   DOI: 10.3390/cells11101677
20752  Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.  Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.  J Toxicol Sci  2022  47(6):249-255  PubMed ID: 35650141   DOI: 10.2131/jts.47.249
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20840  Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.  Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.  Sci Rep  2022  12(1):14520  PubMed ID: 36008442   DOI: 10.1038/s41598-022-18572-3
20911  Imanishi S, Nagata S, Fujita T, Fujii H.  Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.  Int J Exp Pathol  2022    PubMed ID: 36153641   DOI: 10.1111/iep.12457
20926  Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.  Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.  Redox Biol  2022  57:102514  PubMed ID: 36279630   DOI: 10.1016/j.redox.2022.102514
13301  Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.  Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.  J Biomater Sci Polym Ed  2021  32(3):405-416  PubMed ID: 33074050   DOI: 10.1080/09205063.2020.1838045
13453  SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima  Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor  Drug Metabolism and Pharmacokinetics  2021    PubMed ID: 33515843   DOI: 10.1016/j.dmpk.2020.11.002
20006  Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.  Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.  Pharmaceutics  2021  13(1)  PubMed ID: 33430003   DOI: 10.3390/pharmaceutics13010078
20035  Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.  Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.  Glycoconj J  2021  38(1):45-54  PubMed ID: 33523362   DOI: 10.1007/s10719-020-09970-8
20110  Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.  Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.  J Biochem  2021    PubMed ID: 33844018   DOI: 10.1093/jb/mvab049
20136  El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.  MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33886022   DOI: 10.1245/s10434-021-09778-2
15116  Toshiaki TAKEZAWA  Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes  Nano Biomedicine  2021  13:1-7    DOI: 10.11344/nano.13.1
15515  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.  A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment  Cancers (Basel)  2021  13(16):3997  PubMed ID: 34439154   DOI: 10.3390/cancers13163997
16049  Endo A, Asayama S.  Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization  Pharmaceutics  2021  13(12):2084  PubMed ID: 34959365   DOI: 10.3390/pharmaceutics13122084
16135  Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.  A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals  Free Radic Biol Med  2021  163:297-305  PubMed ID: 33359688   DOI: 10.1016/j.freeradbiomed.2020.12.028
20621  Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.  Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.  J Toxicol Sci  2021  46(12):569-587  PubMed ID: 34853243   DOI: 10.2131/jts.46.569
16527  Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.  Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach  Tumour Biol  2021  43(1):309-325  PubMed ID: 34897107   DOI: 10.3233/TUB-211507
16876  Takemura A, Gong S, Sato T, Kawaguchi M, Sekine S, Kazuki Y, Horie T, Ito K.  Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells  J Pharm Sci  2021  110(9):3306-3312  PubMed ID: 34097978   DOI: 10.1016/j.xphs.2021.06.001
16984  Kawase A, Hirosoko M, Sugihara Y, Koyama Y, Fukae A, Shimada H, Iwaki M.  NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells  Pharmaceuticals (Basel)  2021  14(3):239.  PubMed ID: 33800412   DOI: 10.3390/ph14030239
11062  Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto  Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation  Journal of Molecular Liquids  2020  299:112166    DOI: 10.1016/j.molliq.2019.112166
12988  Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.  Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.  Sci Rep  2020    PubMed ID: 32317652   DOI: 10.1038/s41598-020-63362-4
13110  Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.  Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.  J Biosci Bioeng  2020    PubMed ID: 32636145   DOI: 10.1016/j.jbiosc.2020.05.010
13491  Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai  Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide  Fundamental Toxicological Sciences  2020  7 :161-166    DOI: 10.2131/fts.7.161
14497  Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.  Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device  R Soc Open Sci  2020  7(7):200027  PubMed ID: 32874617   DOI: 10.1098/rsos.200027
14851  Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.  Protective Effects of Rice Peptide Oryza Peptide-P60 against Oxidative Injury through Activation of Nrf2 Signaling Pathway In Vitro and In Vivo  ACS Omega  2020  5(22):13096-13107  PubMed ID: 32548495   DOI: 10.1021/acsomega.0c01016
15192  Takagi K, Midorikawa Y, Takayama T, Abe H, Fujiwara K, Soma M, Nagase H, Miki T, Fukuda N.  Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells  Molecules  2020  25(12):2883  PubMed ID: 32585841   DOI: 10.3390/molecules25122883
16623  Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.  Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A  Anticancer Res  2020  40(1):161-168  PubMed ID: 31892564   DOI: 10.21873/anticanres.13937
16883  Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.  Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines  Toxicol In Vitro  2020  69:104999.  PubMed ID: 32949729   DOI: 10.1016/j.tiv.2020.104999
17874  Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.  Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells  J Histochem Cytochem  2019  67(2):129-141  PubMed ID: 30303767   DOI: 10.1369/0022155418804507
11540  Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.  A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.  Virol. J.  2019    PubMed ID: 31046787   DOI: 10.1186/s12985-019-1169-x
11585  Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.  Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.  Medicines (Basel)  2019    PubMed ID: 31163644   DOI: 10.3390/medicines6020063
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
10371  Akito Endo, Shoichiro Asayama  Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery  Journal of Minerals and Materials Characterization and Engineering  2019  7:94802,8    DOI: 10.4236/jmmce.2019.75016
10854  Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki  PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces  Sensors and Actuators B: Chemical  2019  287:486-495    DOI: 10.1016/j.snb.2019.02.067
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920   DOI: 10.18433/jpps30444
12437  Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.  Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry  PLoS One  2019  14(3):e0214000  PubMed ID: 30875389   DOI: 10.1371/journal.pone.0214000
14893  Morikawa T, Nagatomo A, Oka T, Miki Y, Taira N, Shibano-Kitahara M, Hori Y, Muraoka O, Ninomiya K.  Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism  Int J Mol Sci  2019  ;20(24):6322  PubMed ID: 31847420   DOI: 10.3390/ijms20246322
4214  Matsumura K, Imai H, Go Y, Kusuhara M, Yamaguchi K, Shirai T, Ohshima K.  Transcriptional activation of a chimeric retrogene PIPSL in a hominoid ancestor.  Gene  2018    PubMed ID: 30096459   DOI: 10.1016/j.gene.2018.08.033
4216  Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.  Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.  Cell Commun. Signal  2018    PubMed ID: 30180849   DOI: 10.1186/s12964-018-0262-x
4222  Miyamoto D, Hara T, Hyakutake A, Nakazawa K.  Changes in HepG2 spheroid behavior induced by differences in the gap distance between spheroids in a micropatterned culture system.  J. Biosci. Bioeng.  2018    PubMed ID: 29352710   DOI: 10.1016/j.jbiosc.2017.12.013
4340  Nagatome M, Kondo Y, Kadowaki D, Saishyo Y, Irikura M, Irie T, Ishitsuka Y.  Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced by N-acetyl-p-benzoquinone imine.  Heliyon  2018    PubMed ID: 29560444   DOI: 10.1016/j.heliyon.2018.e00521
9973  Kawakami K, Moritani C, Uraji M, Fujita A, Kawakami K, Hatanaka T, Suzaki E, Tsuboi S.  Hepatoprotective effects of rice-derived peptides against acetaminophen-induced damage in mice.  J Clin Biochem Nutr  2017  60:115-120  PubMed ID: 28366990   DOI: 10.3164/jcbn.16-44
10185  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773   DOI: 10.1038/bjc.2017.65
10595  Uemura T, Takasaka T, Igarashi K, Ikegaya H.  Spermine oxidase promotes bile canalicular lumen formation through acrolein production.  Sci Rep  2017  7:14841  PubMed ID: 29093526   DOI: 10.1038/s41598-017-14929-1
12220  Shoichiro Asayama, Mizuki Sakata, Hiroyoshi Kawakami  Structure-activity relationship between Zn 2+-chelated alkylated poly(1-vinylimidazole) and gene transfection  J Inorg Biochem  2017  173:120-125  PubMed ID: 28511062   DOI: 10.1016/j.jinorgbio.2017.05.007
14592  Kusama K, Okamoto Y, Saito K, Kasahara T, Murata T, Ueno Y, Kobayashi Y, Kamada Y, Miyoshi E.  Reevaluation of Pholiota squarrosa lectin-reactive haptoglobin as a pancreatic cancer biomarker using an improved ELISA system  Glycoconj J  2017  34(4):537-544  PubMed ID: 28455724   DOI: 10.1007/s10719-017-9772-9
14609  Enomoto J, Kageyama T, Osaki T, Bonalumi F, Marchese F, Gautieri A, Bianchi E, Dubini G, Arrigoni C, Moretti M, Fukuda J.  Catch-and-Release of Target Cells Using Aptamer-Conjug  Sci Rep  2017  7:43375  PubMed ID: 28266533   DOI: 10.1038/srep43375
9576  Sugai S, Yoshikawa T, Iwama T, Tsuchiya N, Ueda N, Fujinami N, Shimomura M, Zhang R, Kaneko S, Uemura Y, Nakatsura T.  Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T lymphocyte-mediated killing is increased by zoledronate.  Int. J. Oncol.  2016  48:1794-804  PubMed ID: 26936487   DOI: 10.3892/ijo.2016.3403
9946  Abiko Y, Lin FY, Lee H, Puga A, Kumagai Y.  Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator.  J Toxicol Sci  2016  41:775-781  PubMed ID: 27853106   DOI: 10.2131/jts.41.775
10020  Moriyama K, Naito S, Wakabayashi R, Goto M, Kamiya N.  Enzymatically prepared redox-responsive hydrogels as potent matrices for hepatocellular carcinoma cell spheroid formation.  Biotechnol J  2016  11:1452-1460  PubMed ID: 27617786   DOI: 10.1002/biot.201600087
4039  Oshikata-Miyazaki A, Takezawa T.  Development of an oxygenation culture method for activating the liver-specific functions of HepG2 cells utilizing a collagen vitrigel membrane chamber.  Cytotechnology  2016  68(5):1801-11  PubMed ID: 26660096   DOI: 10.1007/s10616-015-9934-1
12685  Takei T, Kitazono J, Tanaka S, Nishimata H, Yoshida M.  Necrotic regions are absent in fiber-shaped cell aggregates, approximately 100 μm in diameter  Artif Cells Nanomed Biotechnol  2016  44(1):62-5  PubMed ID: 24813225   DOI: 10.3109/21691401.2014.909824
12946  Yun YS, Tajima M, Takahashi S, Takahashi Y, Umemura M, Nakano H, Park HS, Inoue H.  Two Alkaloids from Bulbs of Lycoris sanguinea M AXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB  Phytother Res  2016  30(10):1689-1695  PubMed ID: 27388056   DOI: 10.1002/ptr.5676
7373  Takei T, Aokawa R, Shigemitsu T, Kawakami K, Yoshida M.  Fabrication of uniformly cell-laden porous scaffolds using a gas-in-liquid templating technique.  J. Biosci. Bioeng.  2015  120:577-81  PubMed ID: 25912452   DOI: 10.1016/j.jbiosc.2015.03.017
7456  Okina Y, Takeuchi F, Yokomichi T, Takada Y, Kataoka T.  Cardenolide aglycones inhibit tumor necrosis factor α-induced expression of intercellular adhesion molecule-1 at the translation step by blocking Na⁺/K⁺-ATPase  Biol. Pharm. Bull.  2015  38:39-47  PubMed ID: 25744456   DOI: 10.1248/bpb.b14-00532
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5372  Nakajima Y, Kanno T, Nagaya T, Kuribayashi K, Nakano T, Gotoh A, Nishizaki T.  Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.  Cell Physiol Biochem  2015  35(1):51-60  PubMed ID: 25547995   DOI: 10.1159/000369674
14967  Higashi T, Hayashi H, Ishimoto T, Takeyama H, Kaida T, Arima K, Taki K, Sakamoto K, Kuroki H, Okabe H, Nitta H, Hashimoto D, Chikamoto A, Beppu T, Baba H.  miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells  Br J Cancer  2015  113(2):252-8  PubMed ID: 26125451   DOI: 10.1038/bjc.2015.170
15231  Motoyama K, Hirai Y, Nishiyama R, Maeda Y, Higashi T, Ishitsuka Y, Kondo Y, Irie T, Era T, Arima H.  Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells  Beilstein J Org Chem  2015  11:2079-86  PubMed ID: 26664628   DOI: 10.3762/bjoc.11.224
5589  Ozeki M, Kato H, Tamaki K.  Development of a novel miniplex DNA identification system for the Japanese population  Leg Med (Tokyo)  2015  17(3):205-9  PubMed ID: 25596639   DOI: 10.1016/j.legalmed.2014.12.007
18174  Tameda M, Sugimoto K, Shiraki K, Yamamoto N, Okamoto R, Usui M, Ito M, Takei Y, Nobori T, Kojima T, Suzuki H, Uchida M, Uchida K.  Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility  Int J Oncol  2014  45(2):541-8  PubMed ID: 24841500   DOI: 10.3892/ijo.2014.2445
18953  Ninomiya K, Kawabata S, Tashita H, Shimizu N.  Ultrasound-mediated drug delivery using liposomes modified with a thermosensitive polymer  Ultrason Sonochem  2014  21(1):310-6  PubMed ID: 23948493   DOI: 10.1016/j.ultsonch.2013.07.014
10275  Nobumasa Hara, Tomoko Shibata, Harumi Osago, Kazuo Yamada, Mikako Tsuchiya  Formation of [nicotinamide-²H₃]NAD⁺ From [²H₄]nicotinamide and [²H₄]nicotinic Acid in Human HepG2N Cells and Involvement of ²H/¹H Exchange at the Redox Site of NAD⁺/NADH  J Nutr Sci Vitaminol (Tokyo)  2014  60(1):17-21  PubMed ID: 24759255   DOI: 10.3177/jnsv.60.17
10281  Motomu Shoji, Kiyotaka Nakagawa, Akio Watanabe, Tsuyoshi Tsuduki, Teiko Yamada, Shigefumi Kuwahara, Fumiko Kimura, Teruo Miyazawa  Comparison of the Effects of Curcumin and Curcumin Glucuronide in Human Hepatocellular Carcinoma HepG2 Cells  Food Chem  2014  151:126-32  PubMed ID: 24423511   DOI: 10.1016/j.foodchem.2013.11.021
14194  Naoki Tanigawa, Sachiko Yano, Akira Higashibata, Yoshikazu Tsuchiya, Haruna Tanii, Noboru Ando, Koji Kubota, Mutsumu Nagase  Development and Validation of a Closed Chamber for Cell Culture Experiments in Space  Biological Sciences in Space  2014  28:1-5    DOI: 10.2187/bss.28.1
17095  Mori M, Tiang G, Higuchi K.  AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform  Amyloid  2014  21(1):1-8  PubMed ID: 24228751   DOI: 10.3109/13506129.2013.852529
18855  Hirano S, Kataoka T.  Deoxynivalenol induces ectodomain shedding of TNF receptor 1 and thereby inhibits the TNF-α-induced NF-κB signaling pathway  Eur J Pharmacol  2013  701(1-3):144-51  PubMed ID: 23357557   DOI: 10.1016/j.ejphar.2013.01.019
18957  Ninomiya K, Kaneda K, Kawashima S, Miyachi Y, Ogino C, Shimizu N.  Cell-SELEX based selection and characterization of DNA aptamer recognizing human hepatocarcinoma  Bioorg Med Chem Lett  2013  23(6):1797-802  PubMed ID: 23403083   DOI: 10.1016/j.bmcl.2013.01.040
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19097  Orimoto A, Suzuki T, Ueno A, Kawai T, Nakamura H, Kanamori T.  Effect of 2-hydroxyethyl methacrylate on antioxidant responsive element-mediated transcription: a possible indication of its cytotoxicity  PLoS One  2013  8(3):e58907  PubMed ID: 23516576   DOI: 10.1371/journal.pone.0058907
5844  Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.  1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.  Pharmacology  2013  91(5-6):339-45  PubMed ID: 23817168   DOI: 10.1159/000351747
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15922  Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.  Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers  Proc Natl Acad Sci U S A   2013  110(6):2105-10  PubMed ID: 23345451   DOI: 10.1073/pnas.1214233110
15936  Kondo Y, Ishitsuka Y, Kadowaki D, Fukumoto Y, Miyamoto Y, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T.  Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation  J Pharm Pharmacol  2013  65(3):390-401  PubMed ID: 23356848   DOI: 10.1111/j.2042-7158.2012.01602.x
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8234  Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.  Cell micropatterning inside a microchannel and assays under a stable concentration gradient.  J. Biosci. Bioeng.  2010  110:230-7  PubMed ID: 20547384   DOI: 10.1016/j.jbiosc.2010.02.001
8237  Sakai Y, Yoshida S, Yoshiura Y, Mori R, Tamura T, Yahiro K, Mori H, Kanemura Y, Yamasaki M, Nakazawa K.  Effect of microwell chip structure on cell microsphere production of various animal cells.  J. Biosci. Bioeng.  2010  110:223-9  PubMed ID: 20547385   DOI: 10.1016/j.jbiosc.2010.01.021
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