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22463
Otsuka Y, Yano M.
FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production.
FEBS Open Bio
2025
PubMed ID: 39821719
DOI: 10.1002/2211-5463.13967
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22558
Uzu M, Takezawa T.
Potential of connexin 32 as a predictive marker for drug-induced cholestatic liver injury in a collagen vitrigel-culture model of HepG2-NIAS cells, a new subline of HepG2 cells, with bile canaliculus-like structures.
J Toxicol Sci
2025
50(3):135-145
PubMed ID: 40024757
DOI: 10.2131/jts.50.135
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22636
Daidouji Y, Suzuki S, Wang X, Fahreza RR, Nemoto E, Yamada S.
Periodontal inflammation potentially inhibits hepatic cytochrome P450 expression and disrupts the omega-3 epoxidation pathway in a murine model
J Dent Sci
2025
20(1):444-451
PubMed ID: 39873042
DOI: 10.1016/j.jds.2024.05.028
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21548
Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.
An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.
J Pharmacol Sci
2024
154(1):37-46
PubMed ID: 38081682
DOI: 10.1016/j.jphs.2023.11.005
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21661
Katoh M, Fujii T, Tabuchi Y, Shimizu T, Sakai H.
Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect.
J Physiol Sci
2024
74(1):23
PubMed ID: 38561668
DOI: 10.1186/s12576-024-00914-7
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21904
Negoro R, Ouchi A, Deguchi S, Takayama K, Fujita T.
Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.
Biol Pharm Bull
2024
47(8):1422-1428
PubMed ID: 39111864
DOI: 10.1248/bpb.b24-00202
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22004
Urakawa D, Shioiridani Y, Igata S, Hou DX, Sakao K.
Comparative Analysis of Acetylated Flavonoids' Chemopreventive Effects in Different Cancer Cell Lines
Int J Mol Sci
2024
25(14):7689.
PubMed ID: 39062932
DOI: 10.3390/ijms25147689
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22095
Toma T, Miyakawa N, Arakaki Y, Watanabe T, Nakahara R, Ali TFS, Biswas T, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H.
An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models.
Diabetologia
2024
67(11):2568-2584
PubMed ID: 39251430
DOI: 10.1007/s00125-024-06260-y
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22486
Yamada K, Mukaimine A, Nakamura A, Kusakari Y, Pradipta AR, Chang TC, Tanaka K.
Chemistry-driven translocation of glycosylated proteins in mice
Nat Commun
2024
15(1):7409
PubMed ID: 39358337
DOI: 10.1038/s41467-024-51342-5
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22654
Morikawa T, Inoue N, Yamamoto S, Shiotani M, Manse Y, Ninomiya K.
Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino
J Nat Med
2024
78(3):709-721
PubMed ID: 38575838
DOI: 10.1007/s11418-024-01799-x
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22655
Saeki T, Yamamoto S, Akaki J, Tanaka T, Nakasone M, Ikeda H, Wang W, Inoue M, Manse Y, Ninomiya K, Morikawa T.
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
J Nat Med
2024
78(3):576-589
PubMed ID: 38662301
DOI: 10.1007/s11418-024-01803-4
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19558
Kurawaka M, Sasaki N, Yamazaki Y, Shimura F.
Near-Physiological Concentrations of Extracellular Pyruvate Stimulated Glucose Utilization along with Triglyceride Accumulation and Mitochondrial Activity in HepG2 Cells
J Nutr Sci Vitaminol (Tokyo)
2023
69(5):314-325
PubMed ID: 37940572
DOI: 10.3177/jnsv.69.314
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19640
Sakao K, Saruwatari H, Minami S, Hou DX.
Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells
Int J Mol Sci
2023
24(23):16652
PubMed ID: 38068974
DOI: 10.3390/ijms242316652
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19644
Nakamura M, Urakawa D, He Z, Akagi I, Hou DX, Sakao K.
Apoptosis Induction in HepG2 and HCT116 Cells by a Novel Quercetin-Zinc (II) Complex: Enhanced Absorption of Quercetin and Zinc (II)
Int J Mol Sci
2023
24(24):17457
PubMed ID: 38139286
DOI: 10.3390/ijms242417457
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19989
Kodama S, Matsumoto S, Takamura Y, Fujihara M, Watanabe M, Ono A, Kakuta H.
Structural characterization of 1,3-bis-tert-butyl monocyclic benzene derivatives with agonistic activity towards retinoid X receptor alpha
Toxicol Lett
2023
15:373:76-83.
PubMed ID: 36368620
DOI: 10.1016/j.toxlet.2022.11.003
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21179
Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.
Lysine long-chain fatty acylation regulates the TEAD transcription factor.
Cell Rep
2023
112388
PubMed ID: 37060904
DOI: 10.1016/j.celrep.2023.112388
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21481
Nagatomo A, Kohno M, Kawakami H, Manse Y, Morikawa T.
Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver.
J Nat Med
2023
PubMed ID: 37973705
DOI: 10.1007/s11418-023-01756-0
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22032
Shizu R, Otsuka Y, Ishii C, Ezaki K, Yoshinari K.
PPARα Induces the Expression of CAR That Works as a Negative Regulator of PPARα Functions in Mouse Livers.
Int J Mol Sci
2023
24(4)
PubMed ID: 36835365
DOI: 10.3390/ijms24043953
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17664
Matsumura M, Murakami M, Funaba M.
Transcriptional activation of hepcidin by the microphthalmia/transcription factor E family
Cell Biochem Funct
2022
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PubMed ID: 36062805
DOI: 10.1002/cbf.3739
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17682
Okumura M, Iwakiri T, Yoshikawa N, Nagatomo T, Ayabe T, Tsuneyoshi I, Ikeda R.
Hepatocyte Growth Factor Enhances Antineoplastic Effect of 5-Fluorouracil by Increasing UPP1 Expression in HepG2 Cells
Int J Mol Sci
2022
23(16):9108
PubMed ID: 36012373
DOI: 10.3390/ijms23169108
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20482
Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.
Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.
Int J Oncol
2022
60(1)
PubMed ID: 34913069
DOI: 10.3892/ijo.2021.5294
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20514
Takezawa T, Uzu M.
HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane.
J Toxicol Sci
2022
47(1):39-50
PubMed ID: 34987140
DOI: 10.2131/jts.47.39
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20608
Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, Shibasaka A, Muraoka O, Ninomiya K, Yoshikawa M, Manse Y, Morikawa T.
Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
J Nat Med
2022
PubMed ID: 35292883
DOI: 10.1007/s11418-022-01614-5
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20639
Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.
Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.
Oncol Rep
2022
47(4)
PubMed ID: 35169858
DOI: 10.3892/or.2022.8282
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20691
Kajiwara K, Osaki H, Greßies S, Kuwata K, Kim JH, Gensch T, Sato Y, Glorius F, Yamaguchi S, Taki M.
A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.
Nat Commun
2022
13(1):2533
PubMed ID: 35534485
DOI: 10.1038/s41467-022-30153-6
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16451
Kitano H, Kawabe Y, Kamihira M.
HepG2-Based Designer Cells with Heat-Inducible Enhanced Liver Functions
Cells
2022
11(7):1194
PubMed ID: 35406758
DOI: 10.3390/cells11071194
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16644
Negoro R, Tasaka M, Deguchi S, Takayama K, Fujita T.
Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System
Cells
2022
11(10):1677
PubMed ID: 35626714
DOI: 10.3390/cells11101677
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20752
Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K.
Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells.
J Toxicol Sci
2022
47(6):249-255
PubMed ID: 35650141
DOI: 10.2131/jts.47.249
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20799
Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.
HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.
Nat Commun
2022
13(1):4355
PubMed ID: 35906200
DOI: 10.1038/s41467-022-32034-4
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20840
Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.
Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines.
Sci Rep
2022
12(1):14520
PubMed ID: 36008442
DOI: 10.1038/s41598-022-18572-3
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20842
Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.
Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.
J Oral Microbiol
2022
14(1):2105013
PubMed ID: 35937899
DOI: 10.1080/20002297.2022.2105013
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20911
Imanishi S, Nagata S, Fujita T, Fujii H.
Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma.
Int J Exp Pathol
2022
PubMed ID: 36153641
DOI: 10.1111/iep.12457
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20926
Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biol
2022
57:102514
PubMed ID: 36279630
DOI: 10.1016/j.redox.2022.102514
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22034
Nagatomo A, Ninomiya K, Marumoto S, Sakai C, Watanabe S, Ishikawa W, Manse Y, Kikuchi T, Yamada T, Tanaka R, Muraoka O, Morikawa T.
A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells.
Int J Mol Sci
2022
23(21)
PubMed ID: 36361930
DOI: 10.3390/ijms232113141
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13301
Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Noncorrelative relation between in vitro and in vivo for plasmid DNA transfection by succinylated polyethylenimine muscular injection.
J Biomater Sci Polym Ed
2021
32(3):405-416
PubMed ID: 33074050
DOI: 10.1080/09205063.2020.1838045
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13453
SeiyaTakemoto, Masataka Nakano, Kaori Nozaki, Tatsuki Fukami, Miki Nakajima
Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor
Drug Metabolism and Pharmacokinetics
2021
PubMed ID: 33515843
DOI: 10.1016/j.dmpk.2020.11.002
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20006
Mori A, Kobayashi Y, Nirasawa K, Negishi Y, Asayama S.
Structure-Activity Relationship of Mono-Ion Complexes for Plasmid DNA Delivery by Muscular Injection.
Pharmaceutics
2021
13(1)
PubMed ID: 33430003
DOI: 10.3390/pharmaceutics13010078
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20035
Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.
Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.
Glycoconj J
2021
38(1):45-54
PubMed ID: 33523362
DOI: 10.1007/s10719-020-09970-8
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20110
Watanabe Y, Tanabe A, Hamakubo T, Nagatoishi S, Tsumoto K.
Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells.
J Biochem
2021
PubMed ID: 33844018
DOI: 10.1093/jb/mvab049
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20136
El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.
Ann Surg Oncol
2021
PubMed ID: 33886022
DOI: 10.1245/s10434-021-09778-2
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15116
Toshiaki TAKEZAWA
Revolution in Cell Culture Technology Based on a Novel Concept for Enclosing Cells using Collagen Vitrigel Membranes
Nano Biomedicine
2021
13:1-7
DOI: 10.11344/nano.13.1
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15515
Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.
A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment
Cancers (Basel)
2021
13(16):3997
PubMed ID: 34439154
DOI: 10.3390/cancers13163997
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16049
Endo A, Asayama S.
Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization
Pharmaceutics
2021
13(12):2084
PubMed ID: 34959365
DOI: 10.3390/pharmaceutics13122084
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16135
Azuma R, Yamasaki T, Sano K, Munekane M, Matsuoka Y, Yamada KI, Mukai T.
A radioiodinated nitroxide probe with improved stability against bioreduction for in vivo detection of lipid radicals
Free Radic Biol Med
2021
163:297-305
PubMed ID: 33359688
DOI: 10.1016/j.freeradbiomed.2020.12.028
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20621
Kodama S, Yoshii N, Ota A, Takeshita JI, Yoshinari K, Ono A.
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats.
J Toxicol Sci
2021
46(12):569-587
PubMed ID: 34853243
DOI: 10.2131/jts.46.569
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16527
Takeba Y, Ohta Y, Ootaki M, Kobayashi T, Kida K, Watanabe M, Koizumi S, Otsubo T, Iiri T, Matsumoto N.
Identification of interleukin-16 production on tumor aggravation in hepatocellular carcinoma by a proteomics approach
Tumour Biol
2021
43(1):309-325
PubMed ID: 34897107
DOI: 10.3233/TUB-211507
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16876
Takemura A, Gong S, Sato T, Kawaguchi M, Sekine S, Kazuki Y, Horie T, Ito K.
Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells
J Pharm Sci
2021
110(9):3306-3312
PubMed ID: 34097978
DOI: 10.1016/j.xphs.2021.06.001
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16984
Kawase A, Hirosoko M, Sugihara Y, Koyama Y, Fukae A, Shimada H, Iwaki M.
NHERF1/EBP50 as a Target for Modulation of MRP Function in HepG2 Cells
Pharmaceuticals (Basel)
2021
14(3):239.
PubMed ID: 33800412
DOI: 10.3390/ph14030239
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22037
Tsuji T, Morita SY, Nakamura Y, Ikeda Y, Kambe T, Terada T.
Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth.
Sci Rep
2021
11(1):2731
PubMed ID: 33526799
DOI: 10.1038/s41598-021-81733-3
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11062
Rahman Md Moshikur, Md Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhamma Moniruzzaman, Masahiro Goto
Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation
Journal of Molecular Liquids
2020
299:112166
DOI: 10.1016/j.molliq.2019.112166
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12988
Ramadhan W, Kagawa G, Moriyama K, Wakabayashi R, Minamihata K, Goto M, Kamiya N.
Construction of higher-order cellular microstructures by a self-wrapping co-culture strategy using a redox-responsive hydrogel.
Sci Rep
2020
PubMed ID: 32317652
DOI: 10.1038/s41598-020-63362-4
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13110
Ramadhan W, Ohama Y, Minamihata K, Moriyama K, Wakabayashi R, Goto M, Kamiya N.
Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids.
J Biosci Bioeng
2020
PubMed ID: 32636145
DOI: 10.1016/j.jbiosc.2020.05.010
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13491
Masahiro Akiyama, Takamitsu Unoki, Yoshito Kumagai
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide
Fundamental Toxicological Sciences
2020
7 :161-166
DOI: 10.2131/fts.7.161
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14497
Yamahira S, Satoh T, Yanagawa F, Tamura M, Takagi T, Nakatani E, Kusama Y, Sumaru K, Sugiura S, Kanamori T.
Stepwise construction of dynamic microscale concentration gradients around hydrogel-encapsulated cells in a microfluidic perfusion culture device
R Soc Open Sci
2020
7(7):200027
PubMed ID: 32874617
DOI: 10.1098/rsos.200027
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14851
Moritani C, Kawakami K, Shimoda H, Hatanaka T, Suzaki E, Tsuboi S.
Protective Effects of Rice Peptide Oryza Peptide-P60 against Oxidative Injury through Activation of Nrf2 Signaling Pathway In Vitro and In Vivo
ACS Omega
2020
5(22):13096-13107
PubMed ID: 32548495
DOI: 10.1021/acsomega.0c01016
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15192
Takagi K, Midorikawa Y, Takayama T, Abe H, Fujiwara K, Soma M, Nagase H, Miki T, Fukuda N.
Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells
Molecules
2020
25(12):2883
PubMed ID: 32585841
DOI: 10.3390/molecules25122883
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16623
Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.
Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A
Anticancer Res
2020
40(1):161-168
PubMed ID: 31892564
DOI: 10.21873/anticanres.13937
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16883
Kamata S, Hashiyama R, Hana-Ika H, Ohkubo I, Saito R, Honda A, Anan Y, Akahoshi N, Noguchi K, Kanda Y, Ishii I.
Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines
Toxicol In Vitro
2020
69:104999.
PubMed ID: 32949729
DOI: 10.1016/j.tiv.2020.104999
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17874
Ozeki M, Aini W, Miyagawa-Hayashino A, Tamaki K.
Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-Stimulated HepG2 Cells
J Histochem Cytochem
2019
67(2):129-141
PubMed ID: 30303767
DOI: 10.1369/0022155418804507
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11540
Ogura S, Tameda M, Sugimoto K, Ikejiri M, Usui M, Ito M, Takei Y.
A substitution in the pre-S1 promoter region is associated with the viral regulation of hepatitis B virus.
Virol. J.
2019
PubMed ID: 31046787
DOI: 10.1186/s12985-019-1169-x
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11585
Okubo S, Komori H, Kuwahara A, Ohta T, Shoyama Y, Uto T.
Screening of Crude Drugs Used in Japanese Kampo Formulas for Autophagy-Mediated Cell Survival of the Human Hepatocellular Carcinoma Cell Line.
Medicines (Basel)
2019
PubMed ID: 31163644
DOI: 10.3390/medicines6020063
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11851
Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.
Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.
Sci Rep
2019
PubMed ID: 31611630
DOI: 10.1038/s41598-019-51462-9
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9810
Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda
Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves
Plant Signal Behav
2019
14(10):e1644594
PubMed ID: 31342859
DOI: 10.1080/15592324.2019.1644594
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10371
Akito Endo, Shoichiro Asayama
Preparation of Zn2+-Chelated Carboxymethyl Poly(1-Vinylimidazole) for Intracellular Zn2+ Delivery
Journal of Minerals and Materials Characterization and Engineering
2019
7:94802,8
DOI: 10.4236/jmmce.2019.75016
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10854
Hideki Iwadate, Masumi Yamada, Naoki Kimura, Rina Hashimoto, Yuya Yajima, Rie Utoh, Minoru Seki
PDMS microstencil plate-supported fabrication of ultra-thin, condensed ECM membranes for separated cell coculture on both surfaces
Sensors and Actuators B: Chemical
2019
287:486-495
DOI: 10.1016/j.snb.2019.02.067
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11906
Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.
Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.
J Pharm Pharm Sci
2019
PubMed ID: 31804920
DOI: 10.18433/jpps30444
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12437
Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
2019
14(3):e0214000
PubMed ID: 30875389
DOI: 10.1371/journal.pone.0214000
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14893
Morikawa T, Nagatomo A, Oka T, Miki Y, Taira N, Shibano-Kitahara M, Hori Y, Muraoka O, Ninomiya K.
Glucose Tolerance-Improving Activity of Helichrysoside in Mice and Its Structural Requirements for Promoting Glucose and Lipid Metabolism
Int J Mol Sci
2019
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PubMed ID: 31847420
DOI: 10.3390/ijms20246322
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21997
Zohra T, Ovais M, Khalil AT, Qasim M, Ayaz M, Shinwari ZK, Ahmad S, Zahoor M.
Bio-guided profiling and HPLC-DAD finger printing of Atriplex lasiantha Boiss.
BMC Complement Altern Med
2019
19(1):4
PubMed ID: 30606171
DOI: 10.1186/s12906-018-2416-1
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19234
Tsuchiya H, Oura S.
Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion
Int J Mol Sci
2018
19(5):1450
PubMed ID: 29757260
DOI: 10.3390/ijms19051450
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Hattori N, Suzuki T, Jinno S, Okeya H, Ishikawa A, Kondo C, Hayashi T, Ito M, Kanamori T, Kawai T, Noguchi T.
Methyl methacrylate activates the Gsta1 promoter.
J. Dent. Res.
2008
87:1117-21
PubMed ID: 19029078
DOI: 10.1177/154405910808701214
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8720
Mori R, Sakai Y, Nakazawa K.
Micropatterned organoid culture of rat hepatocytes and HepG2 cells.
J. Biosci. Bioeng.
2008
106:237-42
PubMed ID: 18929998
DOI: 10.1263/jbb.106.237
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8765
Saigo K, Yoshida K, Ikeda R, Sakamoto Y, Murakami Y, Urashima T, Asano T, Kenmochi T, Inoue I.
Integration of hepatitis B virus DNA into the myeloid/lymphoid or mixed-lineage leukemia (MLL4) gene and rearrangements of MLL4 in human hepatocellular carcinoma.
Hum. Mutat.
2008
29:703-8
PubMed ID: 18320596
DOI: 10.1002/humu.20701
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8786
Tamura T, Sakai Y, Nakazawa K.
Two-dimensional microarray of HepG2 spheroids using collagen/polyethylene glycol micropatterned chip.
J Mater Sci Mater Med
2008
19:2071-7
PubMed ID: 17968500
DOI: 10.1007/s10856-007-3305-1
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18671
Shibata A, Nakagawa K, Sookwong P, Tsuduki T, Tomita S, Shirakawa H, Komai M, Miyazawa T.
Tocotrienol inhibits secretion of angiogenic factors from human colorectal adenocarcinoma cells by suppressing hypoxia-inducible factor-1alpha
J Nutr
2008
138(11):2136-42
PubMed ID: 18936210
DOI: 10.3945/jn.108.093237
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19048
Tonooka K, Kabashima T, Shibata T, Tang C, Yu Z, Kai M.
Facile assay of telomerase activity utilizing a DNA-detectable chemiluminogenic reagent
Anal Sci
2008
24(4):471-5
PubMed ID: 18403837
DOI: 10.2116/analsci.24.471
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8969
Li RS, Nakagawa Y, Liu YJ, Fujisawa Y, Sai S, Nakanishi T, Chapman KE, Seckl JR, Ohzeki T.
Growth hormone inhibits the 11 beta-Hydroxysteroid dehydrogenase type 1 gene promoter activity via insulin-like growth factor I in HepG2 cells
Horm Metab Res
2008
40(4):286-8
PubMed ID: 18548388
DOI: 10.1055/s-2008-1058076
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12797
Yoshinari K, Ueda R, Kusano K, Yoshimura T, Nagata K, Yamazoe Y.
Omeprazole transactivates human CYP1A1 and CYP1A2 expression through the common regulatory region containing multiple xenobiotic-responsive elements
Biochem Pharmacol
2008
76(1):139-45
PubMed ID: 18502397
DOI: 10.1016/j.bcp.2008.04.005
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13723
Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy
J Exp Ther Oncol
2008
7(2):153-67
PubMed ID: 18771089
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14931
Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y.
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
Lab Invest
2008
88(8):873-82
PubMed ID: 18591938
DOI: 10.1038/labinvest.2008.52
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18984
Adachi T, Nakagawa H, Chung I, Hagiya Y, Hoshijima K, Noguchi N, Kuo MT, Ishikawa T.
Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress
J Exp Ther Oncol
2007
6(4):335-48
PubMed ID: 18038766
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19110
Takeba Y, Kumai T, Matsumoto N, Nakaya S, Tsuzuki Y, Yanagida Y, Kobayashi S.
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis
J Pharmacol Sci
2007
104(3):232-42
PubMed ID: 17609585
DOI: 10.1254/jphs.fp0070442
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12662
Sakai Y, Nakazawa K.
Technique for the control of spheroid diameter using microfabricated chips
Acta Biomater
2007
3(6):1033-40
PubMed ID: 17689307
DOI: 10.1016/j.actbio.2007.06.004
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8860
Horiuchi S, Aoyama Y.
Systematic lactose-functionalization of amphiphilic octaamine macrocycle as a gene carrier. Optimization of the charge, size, toxicity, and receptor factors for hepatocyte targeting.
J Control Release
2006
116:107-14
PubMed ID: 16905218
DOI: 10.1016/j.jconrel.2006.07.004
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2257
A new method of competitive reverse transcription polymerase chain reaction with SYBR Gold staining for quantitative analysis of mRNA.
A new method of competitive reverse transcription polymerase chain reaction with SYBR Gold staining for quantitative analysis of mRNA
Electrophoresis
2006
27(14):2865-8
PubMed ID: 16688698
DOI: 10.1002/elps.200500568
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3413
Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio
Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.
J Biochem
2005
138:663-72
PubMed ID: 16428294
DOI: 10.1093/jb/mvi177
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2892
Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E
Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis
J Biochem (Tokyo)
2005
137:17-25
PubMed ID: 15713879
DOI: 10.1093/jb/mvi003
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3407
Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi
Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.
Am J Physiol Endocrinol Metab
2005
288:E1101-9
PubMed ID: 15671080
DOI: 10.1152/ajpendo.00502.2004
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14325
Sugatani J, Sueyoshi T, Negishi M, Miwa M.
Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor, and glucocorticoid receptor
Methods Enzymol
2005
400:92-104
PubMed ID: 16399345
DOI: 10.1016/S0076-6879(05)00006-6
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2894
Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio
A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.
J Biol Chem
2004
279:21282-6
PubMed ID: 15026424
DOI: 10.1074/jbc.M401881200
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9172
Harada K, Ohba K, Ozaki S, Isse K, Hirayama T, Wada A, Nakanuma Y.
Peptide antibiotic human beta-defensin-1 and -2 contribute to antimicrobial defense of the intrahepatic biliary tree.
Hepatology
2004
40:925-32
PubMed ID: 15382127
DOI: 10.1002/hep.20379
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12842
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Use of a perfusion co-culture system consisting of Caco-2 and Hep G2 cell compartments for the kinetic analysis of benzo[a]pyrene toxicity
Altern Lab Anim
2004
32 Suppl 1A:99-103
PubMed ID: 23577440
DOI: 10.1177/026119290403201s15
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12844
Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
Biochem Pharmacol
2004
67(5):989-1000
PubMed ID: 15104253
DOI: 10.1016/j.bcp.2003.11.002
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12845
Choi S, Nishikawa M, Sakoda A, Sakai Y.
Feasibility of a simple double-layered coculture system incorporating metabolic processes of the intestine and liver tissue: application to the analysis of benzo[a]pyrene toxicity
Toxicol In Vitro
2004
18(3):393-402
PubMed ID: 15046787
DOI: 10.1016/j.tiv.2003.09.010
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3793
Yoshida S, Honda A, Matsuzaki Y, Fukushima S, Tanaka N, Takagiwa A, Fujimoto Y, Miyazaki H, Salen G.
Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.
Steroids
2003
68(1):73-83
PubMed ID: 12475725
DOI: 10.1016/s0039-128x(02)00117-4
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3794
Sakai Y, Fukuda O, Choi SH, Sakoda A.
Development of a biohybrid simulator for absorption and biotransformation processes in humans based on in vitro models of small intestine and liver tissues.
J Artif Organs
2003
6(4):273-81
PubMed ID: 14691670
DOI: 10.1007/s10047-003-0238-4
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14329
Hata K, Hori K, Ogasawara H, Takahashi S.
Anti-leukemia activities of Lup-28-al-20(29)-en-3-one, a lupane triterpene
Toxicol Lett
2003
143(1):1-7
PubMed ID: 12697374
DOI: 10.1016/s0378-4274(03)00092-4
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9400
Ikeda T, Zhang J, Chano T, Mabuchi A, Fukuda A, Kawaguchi H, Nakamura K, Ikegawa S.
Identification and characterization of the human long form of Sox5 (L-SOX5) gene.
Gene
2002
298:59-68
PubMed ID: 12406576
DOI: 10.1016/s0378-1119(02)00927-7
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3787
Mikiko Shimizu, Hiro-omi Tamura
Identification and Localization of Two Hydroxysteroid Sulfotransferases in the Human Brain
Journal of Health Science
2002
48:467-472
DOI: 10.1248/jhs.48.467
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3773
Hirano R, Igarashi O, Kondo K, Itakura H, Matsumoto A.
Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.
Lipids
2001
36(4):401-6
PubMed ID: 11383693
DOI: 10.1007/s11745-001-0735-3
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6400
Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.
A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.
J Orthop Sci
2001
6(3):269-75
PubMed ID: 11484122
DOI: 10.1007/s007760100046
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