| 利用者成果(英) |
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19711
Asahi T, Abe S, Cui G, Shimba A, Nabekura T, Miyachi H, Kitano S, Ohira K, Dijkstra JM, Miyazaki M, Shibuya A, Ohno H, Ikuta K.
Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches
Elife
2023
12:e84209
PubMed ID: 37352115
DOI: 10.7554/eLife.84209
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21433
Sadakane H, Matsumura M, Murakami M, Itoyama E, Shimokawa F, Sakota S, Yoshioka H, Kawabata H, Matsui T, Funaba M.
Weak response of bovine hepcidin induction to iron through decreased expression of Smad4.
FASEB J
2023
37(11):e23243
PubMed ID: 37800888
DOI: 10.1096/fj.202301186RR
|
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21450
Sato J, Satoh Y, Yamamoto T, Watanabe T, Matsubara S, Satake H, Kimura AP.
PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene.
Gene
2023
893:147907
PubMed ID: 37858745
DOI: 10.1016/j.gene.2023.147907
|
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21511
Tominaga S, Yoshioka H, Yokota S, Tsukiboshi Y, Suzui M, Nagai M, Hara H, Maeda T, Miura N.
Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice.
Environ Health Prev Med
2023
28:78
PubMed ID: 38092388
DOI: 10.1265/ehpm.23-00205
|
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17702
Homma T, Kobayashi S, Fujii J.
Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in F
Cells
2022
11(10):1603
PubMed ID: 35626640
DOI: 10.3390/cells11101603
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17704
Homma T, Osaki T, Kobayashi S, Sato H, Fujii J.
d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione
J Clin Biochem Nutr
2022
71(1):48-54
PubMed ID: 35903611
DOI: 10.3164/jcbn.21-143
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18222
Homma T, Nishino Y, Fujii J, Yokoyama C.
Flow cytometric determination of ferroptosis using a rat monoclonal antibody raised against ferroptotic cells
J Immunol Methods
2022
510:113358
PubMed ID: 36126779
DOI: 10.1016/j.jim.2022.113358
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20637
Tagawa R, Kobayashi M, Sakurai M, Yoshida M, Kaneko H, Mizunoe Y, Nozaki Y, Okita N, Sudo Y, Higami Y.
Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids.
Int J Mol Sci
2022
23(3)
PubMed ID: 35163722
DOI: 10.3390/ijms23031793
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20950
Yoshioka H, Tominaga S, Suzui M, Shinohara Y, Maeda T, Miura N.
Involvement of Npas2 and Per2 modifications in zinc-induced acute diurnal toxicity in mice.
J Toxicol Sci
2022
47(12):547-553
PubMed ID: 36450499
DOI: 10.2131/jts.47.547
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21002
Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J.
Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.
iScience
2022
25(12):105662
PubMed ID: 36505926
DOI: 10.1016/j.isci.2022.105662
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13346
Kobayashi S, Harada Y, Homma T, Yokoyama C, Fujii J.
Characterization of a rat monoclonal antibody raised against ferroptotic cells.
J Immunol Methods
2021
PubMed ID: 33189725
DOI: 10.1016/j.jim.2020.112912
|
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20021
Homma T, Kobayashi S, Sato H, Fujii J.
Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation.
Arch Biochem Biophys
2021
700:108775
PubMed ID: 33493440
DOI: 10.1016/j.abb.2021.108775
|
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20131
Siswanto FM, Oguro A, Imaoka S.
Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2.
J Biol Chem
2021
100704
PubMed ID: 33895141
DOI: 10.1016/j.jbc.2021.100704
|
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20245
Homma T, Kobayashi S, Conrad M, Konno H, Yokoyama C, Fujii J.
Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.
Nitric Oxide
2021
115:34-43
PubMed ID: 34329739
DOI: 10.1016/j.niox.2021.07.003
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20279
Une N, Takano-Kasuya M, Kitamura N, Ohta M, Inose T, Kato C, Nishimura R, Tada H, Miyagi S, Ishida T, Unno M, Kamei T, Gonda K.
The anti-angiogenic agent lenvatinib induces tumor vessel normalization and enhances radiosensitivity in hepatocellular tumors.
Med Oncol
2021
38(6):60
PubMed ID: 33881631
DOI: 10.1007/s12032-021-01503-z
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11821
Saparbay J, Tanaka Y, Tanimine N, Ohira M, Ohdan H.
Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice.
Transpl. Int.
2020
33(2):229-243
PubMed ID: 31560810
DOI: 10.1111/tri.13536
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6951
Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T4, Otani T5, Takeuchi H6, Jimi E7, Hirata M8.
GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin.
J Endocrinol
2020
PubMed ID: 31693486
DOI: 10.1530/JOE-19-0288
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11951
Liew LC, Gailhouste L, Tan GC, Yamamoto Y, Takeshita F, Nakagama H, Ochiya T.
MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells.
Stem Cells
2020
PubMed ID: 31828873
DOI: 10.1002/stem.3136
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12082
Kobayashi S, Ikeda Y, Shigeno Y, Konno H, Fujii J.
γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice.
Amino Acids
2020
PubMed ID: 32170467
DOI: 10.1007/s00726-020-02835-2
|
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12116
Noguchi T, Ikeda M, Murakami M, Masuzawa M, Imamura T, Hashimoto O, Matsui T, Funaba M.
Regulatory expression of bone morphogenetic protein 6 by 2,2'-dipyridyl.
Biochim Biophys Acta Gen Subj
2020
PubMed ID: 32251709
DOI: 10.1016/j.bbagen.2020.129610
|
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13036
Tanaka M, Sato A, Kishimoto Y, Mabashi-Asazuma H, Kondo K, Iida K.
Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes.
Nutrients
2020
PubMed ID: 32443660
DOI: 10.3390/nu12051479
|
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13060
Mayama S, Hamazaki N, Maruyama Y, Matsubara S, Kimura AP.
Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells.
J Reprod Dev
2020
PubMed ID: 32507774
DOI: 10.1262/jrd.2019-161
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13073
Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.
Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.
Free Radic Biol Med
2020
PubMed ID: 32553752
DOI: 10.1016/j.freeradbiomed.2020.06.005
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13090
Homma T, Kobayashi S, Fujii J.
Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs).
Free Radic Res
2020
PubMed ID: 32605459
DOI: 10.1080/10715762.2020.1780229
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13566
Kim DH, Sadakane H, Nishikiori Y, Matsumura M, Ikeda M, Diao Z, Jha R, Murakami M, Matsui T, Funaba M.
Factors affecting expression and transcription of uncoupling protein 2 gene
J Vet Med Sci
2020
82(12):1734-1741
PubMed ID: 33162463
DOI: 10.1292/jvms.20-0444
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14835
Yamada T, Tateishi R, Iwai M, Koike K, Todo T.
Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation
Mol Ther Oncolytics
2020
18:535-54
PubMed ID: 32995479
DOI: 10.1016/j.omto.2020.08.010
|
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11550
Shigeto H, Ono T, Ikeda T, Hirota R, Ishida T, Kuroda A, Funabashi H.
Insulin sensor cells for the analysis of insulin secretion responses in single living pancreatic β cells.
Analyst
2019
PubMed ID: 31089611
DOI: 10.1039/c9an00405j
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11603
Aoki N, Matsui Y.
Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.
Mol. Cell. Biol.
2019
PubMed ID: 31208979
DOI: 10.1128/MCB.00154-19
|
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11769
Homma T, Kobayashi S, Fujii J.
Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide.
Biochem. Biophys. Res. Commun.
2019
PubMed ID: 31445701
DOI: 10.1016/j.bbrc.2019.08.073
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11782
Homma T, Kobayashi S, Sato H, Fujii J.
Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro.
Exp. Cell Res.
2019
PubMed ID: 31479686
DOI: 10.1016/j.yexcr.2019.111592
|
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9192
Toru Suzuki, Chisato Kikuguchi, Saori Nishijima, Takeshi Nagashima, Akinori Takahashi, Mariko Okada, Tadashi Yamamoto
Postnatal Liver Functional Maturation Requires Cnot Complex-Mediated Decay of mRNAs Encoding Cell Cycle and Immature Liver Genes
Development
2019
146 (4)
PubMed ID: 30733279
DOI: 10.1242/dev.168146
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10525
Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y.
Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.
Redox Biol
2018
15:115-124
PubMed ID: 29241092
DOI: 10.1016/j.redox.2017.09.007
|
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10795
Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K.
The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.
BMC Cancer
2018
18:317
PubMed ID: 29566670
DOI: 10.1186/s12885-018-4221-0
|
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11103
Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.
Sci Rep
2018
8(1):9072
PubMed ID: 29899468
DOI: 10.1038/s41598-018-27280-w
|
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11100
Nakano R, Ohira M, Yano T, Imaoka Y, Tanaka Y, Ohdan H.
Hepatic irradiation persistently eliminates liver resident NK cells.
PLoS ONE
2018
13(6):e0198904
PubMed ID: 29897952
DOI: 10.1371/journal.pone.0198904
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11157
Germond A, Ichimura T, Chiu LD, Fujita K, Watanabe TM, Fujita H.
Cell type discrimination based on image features of molecular component distribution.
Sci Rep
2018
8(1):11726
PubMed ID: 30082723
DOI: 10.1038/s41598-018-30276-1
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4217
Shinto S, Matsuoka Y, Yamato M, Yamada KI.
Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death.
J Clin Biochem Nutr
2018
PubMed ID: 29610552
DOI: 10.3164/jcbn.17-60
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10033
Nishihara M, Kanda GN, Suzuki T, Yamakado S, Harashima H, Kamiya H.
Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase.
J. Biosci. Bioeng.
2017
123:277-280
PubMed ID: 27746157
DOI: 10.1016/j.jbiosc.2016.09.008
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10211
Fujita K, Iguchi Y, Une M, Watanabe S.
Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β-Muricholic Acid, a Farnesoid X Receptor Antagonist.
Lipids
2017
52:335-344
PubMed ID: 28315136
DOI: 10.1007/s11745-017-4242-5
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10364
Lee J, Homma T, Fujii J.
Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress.
Toxicol. Lett.
2017
277:92-103
PubMed ID: 28642009
DOI: 10.1016/j.toxlet.2017.06.005
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10583
Lee J, Kang ES, Kobayashi S, Homma T, Sato H, Seo HG, Fujii J.
The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production.
Exp. Cell Res.
2017
361:178-191
PubMed ID: 29079265
DOI: 10.1016/j.yexcr.2017.10.017
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7067
Yamada K, Mito F, Matsuoka Y, Ide S, Shikimachi K, Fujiki A, Kusakabe D, Ishida Y, Enoki M, Tada A, Ariyoshi M, Yamasaki T, Yamato M.
Fluorescence probes to detect lipid-derived radicals.
Nat. Chem. Biol.
2016
12:608-13
PubMed ID: 27294322
DOI: 10.1038/nchembio.2105
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9733
Takahashi T, Sugawara W, Takiguchi Y, Takizawa K, Nakabayashi A, Nakamura M, Nagano-Ito M, Ichikawa S.
Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells.
Evid Based Complement Alternat Med
2016
2016:4282758
PubMed ID: 27429636
DOI: 10.1155/2016/4282758
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12291
Saneyuki Ujino, Hironori Nishitsuji, Takayuki Hishiki, Kazuo Sugiyama, Hiroshi Takaku, Kunitada Shimotohno
Hepatitis C virus utilizes VLDLR as a novel entry pathway
Proc Natl Acad Sci U S A
2016
113(1):188-93
PubMed ID: 26699506
DOI: 10.1073/pnas.1506524113
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14124
Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taguchi C, Tateishi S, Kawada T, Kim YI, Murai A, Horio F.
Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12
BMC Genet
2016
17(1):73
PubMed ID: 27266874
DOI: 10.1186/s12863-016-0385-2
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7330
Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N.
Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.
J. Biol. Chem.
2015
290:17520-34
PubMed ID: 26018079
DOI: 10.1074/jbc.M114.635433
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7395
Mutai H, Miya F, Fujii M, Tsunoda T, Matsunaga T.
Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.
PLoS ONE
2015
10:e0124301
PubMed ID: 25875282
DOI: 10.1371/journal.pone.0124301
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15811
Ichi I, Kono N, Arita Y, Haga S, Arisawa K, Yamano M, Nagase M, Fujiwara Y, Arai H.
Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency
Biochim Biophys Acta
2014
1841(1):204-13
PubMed ID: 24184513
DOI: 10.1016/j.bbalip.2013.10.013
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15913
Kurihara M, Shiraishi A, Satake H, Kimura AP.
A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA
J Mol Biol
2014
426(17):3069-93
PubMed ID: 25020229
DOI: 10.1016/j.jmb.2014.06.018
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18997
Akihiro Deguchi
GnT V-Catalyzed N-glycan Products are not increased in Hepatomas
Journal of Glycomics & Lipidomics
2013
01
DOI: 10.4172/2153-0637.s5-003
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19073
Kawahara T, Toso C, Yamaguchi K, Cader S, Douglas DN, Nourbakhsh M, Lewis JT, Churchill TA, Yagita H, Kneteman NM.
Additive effect of sirolimus and anti-death receptor 5 agonistic antibody against hepatocellular carcinoma
Liver Int
2013
33(9):1441-8
PubMed ID: 23895107
DOI: 10.1111/liv.12275
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15764
Burdeos GC, Nakagawa K, Watanabe A, Kimura F, Miyazawa T.
γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6
J Nutr Sci Vitaminol (Tokyo)
2013
59(2):148-51
PubMed ID: 23727646
DOI: 10.3177/jnsv.59.148
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18568
Kimura T, Yoshida K, Yamamoto C, Suzuki M, Uno T, Isobe M, Naka H, Yasuike S, Satoh M, Kaji T, Uchiyama M.
Bis(L-cysteinato)zincate(lI) as a coordination compound that induces metallothionein gene transcription without inducing cell-stress-related gene transcription
J Inorg Biochem
2012
117:140-6
PubMed ID: 23085594
DOI: 10.1016/j.jinorgbio.2012.07.021
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13154
Hideaki Yamamoto, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira
Enhanced liver functions in mouse hepatoma cells by induced overexpression of liver-enriched transcription factor
Biochemical Engineering Journal
2012
60:67-73
DOI: 10.1016/j.bej.2011.10.004
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15762
Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T.
Efficacy of a novel class of RNA interference therapeutic agents
PLoS One
2012
7(8):e42655
PubMed ID: 22916145
DOI: 10.1371/journal.pone.0042655
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8206
Matsubara S, Takahashi T, Kimura AP.
Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression.
Gene
2010
465:17-29
PubMed ID: 20600704
DOI: 10.1016/j.gene.2010.06.006
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8276
Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y.
Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line.
Biochem. J.
2010
429:53-61
PubMed ID: 20433422
DOI: 10.1042/BJ20100223
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15367
Miki T, Iguchi M, Akiba K, Hosono M, Sobue T, Danbara H, Okada N.
Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes
Mol Microbiol
2010
77(4):855-72
PubMed ID: 20545857
DOI: 10.1111/j.1365-2958.2010.07248.x
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19099
Shintaro Katayama, Mutsumi Kanamori-Katayama, Kazumi Yamaguchi, Piero Carninci, Yoshihide Hayashizaki
CAGE-TSSchip: promoter-based expression profiling using the 5'-leading label of capped transcripts
Genome Biology
2007
8:R42
DOI: 10.1186/gb-2007-8-3-r42
|
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3356
Kubota, Koichi
A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection.
J Immunol
2006
176:7576-88
PubMed ID: 16751404
DOI: 10.4049/jimmunol.176.12.7576
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18467
Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T, Mori M.
Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone
Endocrinology
2006
147(9):4292-302
PubMed ID: 16794015
DOI: 10.1210/en.2006-0116
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3336
Kuang M, Liu, S Q, Saijo K, Uchimura E, Huang L, Leong, K W, Lu, M D, Huang, J F, Ohno T
Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity.
Int J Hyperthermia
2005
21:247-57
PubMed ID: 16019851
DOI: 10.1080/02656730500052027
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3189
Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S.
Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system.
Stem Cells
2005
23:903-13
PubMed ID: 16043458
DOI: 10.1634/stemcells.2004-0295
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9007
Emoto M, Miki M, Sarker AH, Nakamura T, Seki Y, Seki S, Ikeda S.
Structure and transcription promoter activity of mouse flap endonuclease 1 gene: alternative splicing and bidirectional promoter.
Gene
2005
357:47-54
PubMed ID: 15967598
DOI: 10.1016/j.gene.2005.05.009
|
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2705
Kushida S, Peng, B G, Uchimura E, Kuang M, Huang L, Miwa M, Ohno T
A tumour vaccine of fixed tumour fragments in a controlled-release vehicle with cytokines for therapy of hepatoma in mice.
Dig Liver Dis
2004
36:478-85
PubMed ID: 15285528
DOI: 10.1016/j.dld.2004.02.010
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19036
Tanaka T, Tomaru Y, Nomura Y, Miura H, Suzuki M, Hayashizaki Y.
Comprehensive search for HNF-1beta-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi
Nucleic Acids Res
2004
32(9):2740-50
PubMed ID: 15148361
DOI: 10.1093/nar/gkh597
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18639
Tomaru Y, Kondo S, Suzuki M, Hayashizaki Y.
A comprehensive search for HNF-3alpha-regulated genes in mouse hepatoma cells by 60K cDNA microarray and chromatin immunoprecipitation/PCR analysis
Biochem Biophys Res Commun
2003
310(2):667-74
PubMed ID: 14521963
DOI: 10.1016/j.bbrc.2003.08.148
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2637
Kasahara M, Watanabe Y, Sumasu M, Nagata T
A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.
Proc Natl Acad Sci U S A
2002
99:13687-92
PubMed ID: 12370446
DOI: 10.1073/pnas.212375299
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2519
Zhang BN, Watanabe S, Kohyama M, Saijo K, Kusakabe M, Ohno T.
Tumor formation suppressed in gammadeltaT knock-out mice.
Cancer Lett
2000
153(1-2):63-6
PubMed ID: 10779631
DOI: 10.1016/s0304-3835(00)00343-8
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