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細胞番号 : 細胞名
RCB1638 : Hepa 1-6  update : 2024/05/14
細胞特性(Comment:英)Mouse cell line derived from hepatoma. Derived from BW7756 tumour in a C57L mouse. Secretes several products such as albumin, alpha-fetoprotein, alpha 1-antitrypin and amylase. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 92110305 prior to order.
細胞特性(日)マウス肝細胞癌由来細胞株。albumin, alpha-fetoprotein, alpha 1-antitrypin, amylaseなどを分泌。ECACC由来株。使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、ECACC 92110305 を必ずご参照ください。
使用条件(英)1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA92110305 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)1) 基礎的研究につきましては、使用制限はありません。しかし、使用条件等がECACCによって随時変更となる可能性があるので、購入前に、ECA92110305 を必ず参照すること。2) 商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 2000
動物種 _mouse < Mammals
動物系統名 C57L
採取組織 liver
病名 hepatopma
細胞分類 cancer
入手歴 overseas, ECACC -> RIKEN Cell Bank
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0327
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (high glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
マウス系統検査 OK
アイソザイム検査 LD, NP
文献情報 Reference(英) 2件
Reference(日) 0件
利用者成果(英) 67件
利用者成果(日) 0件

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20637  Tagawa R, Kobayashi M, Sakurai M, Yoshida M, Kaneko H, Mizunoe Y, Nozaki Y, Okita N, Sudo Y, Higami Y.  Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids.  Int J Mol Sci  2022  23(3)  PubMed ID: 35163722   DOI: 10.3390/ijms23031793
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21002  Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J.  Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.  iScience  2022  25(12):105662  PubMed ID: 36505926   DOI: 10.1016/j.isci.2022.105662
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20021  Homma T, Kobayashi S, Sato H, Fujii J.  Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation.  Arch Biochem Biophys  2021  700:108775  PubMed ID: 33493440   DOI: 10.1016/j.abb.2021.108775
20131  Siswanto FM, Oguro A, Imaoka S.  Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2.  J Biol Chem  2021  100704  PubMed ID: 33895141   DOI: 10.1016/j.jbc.2021.100704
20245  Homma T, Kobayashi S, Conrad M, Konno H, Yokoyama C, Fujii J.  Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction.  Nitric Oxide  2021  115:34-43  PubMed ID: 34329739   DOI: 10.1016/j.niox.2021.07.003
20279  Une N, Takano-Kasuya M, Kitamura N, Ohta M, Inose T, Kato C, Nishimura R, Tada H, Miyagi S, Ishida T, Unno M, Kamei T, Gonda K.  The anti-angiogenic agent lenvatinib induces tumor vessel normalization and enhances radiosensitivity in hepatocellular tumors.  Med Oncol  2021  38(6):60  PubMed ID: 33881631   DOI: 10.1007/s12032-021-01503-z
11821  Saparbay J, Tanaka Y, Tanimine N, Ohira M, Ohdan H.  Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice.  Transpl. Int.  2020  33(2):229-243  PubMed ID: 31560810   DOI: 10.1111/tri.13536
6951  Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T4, Otani T5, Takeuchi H6, Jimi E7, Hirata M8.  GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin.  J Endocrinol  2020    PubMed ID: 31693486   DOI: 10.1530/JOE-19-0288
11951  Liew LC, Gailhouste L, Tan GC, Yamamoto Y, Takeshita F, Nakagama H, Ochiya T.  MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells.  Stem Cells  2020    PubMed ID: 31828873   DOI: 10.1002/stem.3136
12082  Kobayashi S, Ikeda Y, Shigeno Y, Konno H, Fujii J.  γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice.  Amino Acids  2020    PubMed ID: 32170467   DOI: 10.1007/s00726-020-02835-2
12116  Noguchi T, Ikeda M, Murakami M, Masuzawa M, Imamura T, Hashimoto O, Matsui T, Funaba M.  Regulatory expression of bone morphogenetic protein 6 by 2,2'-dipyridyl.  Biochim Biophys Acta Gen Subj  2020    PubMed ID: 32251709   DOI: 10.1016/j.bbagen.2020.129610
13060  Mayama S, Hamazaki N, Maruyama Y, Matsubara S, Kimura AP.  Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells.  J Reprod Dev  2020    PubMed ID: 32507774   DOI: 10.1262/jrd.2019-161
13073  Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.  Free Radic Biol Med  2020    PubMed ID: 32553752   DOI: 10.1016/j.freeradbiomed.2020.06.005
13090  Homma T, Kobayashi S, Fujii J.  Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs).  Free Radic Res  2020    PubMed ID: 32605459   DOI: 10.1080/10715762.2020.1780229
13566  Kim DH, Sadakane H, Nishikiori Y, Matsumura M, Ikeda M, Diao Z, Jha R, Murakami M, Matsui T, Funaba M.  Factors affecting expression and transcription of uncoupling protein 2 gene  J Vet Med Sci  2020  82(12):1734-1741  PubMed ID: 33162463   DOI: 10.1292/jvms.20-0444
14835  Yamada T, Tateishi R, Iwai M, Koike K, Todo T.  Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation  Mol Ther Oncolytics  2020  18:535-54  PubMed ID: 32995479   DOI: 10.1016/j.omto.2020.08.010
11550  Shigeto H, Ono T, Ikeda T, Hirota R, Ishida T, Kuroda A, Funabashi H.  Insulin sensor cells for the analysis of insulin secretion responses in single living pancreatic β cells.  Analyst  2019    PubMed ID: 31089611   DOI: 10.1039/c9an00405j
11603  Aoki N, Matsui Y.  Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.  Mol. Cell. Biol.  2019    PubMed ID: 31208979   DOI: 10.1128/MCB.00154-19
11769  Homma T, Kobayashi S, Fujii J.  Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31445701   DOI: 10.1016/j.bbrc.2019.08.073
11782  Homma T, Kobayashi S, Sato H, Fujii J.  Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro.  Exp. Cell Res.  2019    PubMed ID: 31479686   DOI: 10.1016/j.yexcr.2019.111592
9192  Toru Suzuki, Chisato Kikuguchi, Saori Nishijima, Takeshi Nagashima, Akinori Takahashi, Mariko Okada, Tadashi Yamamoto  Postnatal Liver Functional Maturation Requires Cnot Complex-Mediated Decay of mRNAs Encoding Cell Cycle and Immature Liver Genes  Development  2019  146 (4)  PubMed ID: 30733279   DOI: 10.1242/dev.168146
10525  Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y.  Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways.  Redox Biol  2018  15:115-124  PubMed ID: 29241092   DOI: 10.1016/j.redox.2017.09.007
10795  Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K.  The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes.  BMC Cancer  2018  18:317  PubMed ID: 29566670   DOI: 10.1186/s12885-018-4221-0
11103  Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.  Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.  Sci Rep  2018  8(1):9072  PubMed ID: 29899468   DOI: 10.1038/s41598-018-27280-w
11100  Nakano R, Ohira M, Yano T, Imaoka Y, Tanaka Y, Ohdan H.  Hepatic irradiation persistently eliminates liver resident NK cells.  PLoS ONE  2018  13(6):e0198904  PubMed ID: 29897952   DOI: 10.1371/journal.pone.0198904
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12291  Saneyuki Ujino, Hironori Nishitsuji, Takayuki Hishiki, Kazuo Sugiyama, Hiroshi Takaku, Kunitada Shimotohno  Hepatitis C virus utilizes VLDLR as a novel entry pathway  Proc Natl Acad Sci U S A  2016  113(1):188-93  PubMed ID: 26699506   DOI: 10.1073/pnas.1506524113
14124  Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taguchi C, Tateishi S, Kawada T, Kim YI, Murai A, Horio F.  Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12  BMC Genet  2016  17(1):73  PubMed ID: 27266874   DOI: 10.1186/s12863-016-0385-2
7330  Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N.  Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES.  J. Biol. Chem.  2015  290:17520-34  PubMed ID: 26018079   DOI: 10.1074/jbc.M114.635433
7395  Mutai H, Miya F, Fujii M, Tsunoda T, Matsunaga T.  Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4.  PLoS ONE  2015  10:e0124301  PubMed ID: 25875282   DOI: 10.1371/journal.pone.0124301
15811  Ichi I, Kono N, Arita Y, Haga S, Arisawa K, Yamano M, Nagase M, Fujiwara Y, Arai H.  Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency  Biochim Biophys Acta  2014  1841(1):204-13  PubMed ID: 24184513   DOI: 10.1016/j.bbalip.2013.10.013
15913  Kurihara M, Shiraishi A, Satake H, Kimura AP.  A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA  J Mol Biol  2014  426(17):3069-93  PubMed ID: 25020229   DOI: 10.1016/j.jmb.2014.06.018
18997  Akihiro Deguchi  GnT V-Catalyzed N-glycan Products are not increased in Hepatomas  Journal of Glycomics & Lipidomics  2013  01    DOI: 10.4172/2153-0637.s5-003
19073  Kawahara T, Toso C, Yamaguchi K, Cader S, Douglas DN, Nourbakhsh M, Lewis JT, Churchill TA, Yagita H, Kneteman NM.  Additive effect of sirolimus and anti-death receptor 5 agonistic antibody against hepatocellular carcinoma  Liver Int  2013  33(9):1441-8  PubMed ID: 23895107   DOI: 10.1111/liv.12275
15764  Burdeos GC, Nakagawa K, Watanabe A, Kimura F, Miyazawa T.  γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6  J Nutr Sci Vitaminol (Tokyo)  2013  59(2):148-51  PubMed ID: 23727646   DOI: 10.3177/jnsv.59.148
13154  Hideaki Yamamoto, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira  Enhanced liver functions in mouse hepatoma cells by induced overexpression of liver-enriched transcription factor  Biochemical Engineering Journal  2012  60:67-73     DOI: 10.1016/j.bej.2011.10.004
15762  Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T.  Efficacy of a novel class of RNA interference therapeutic agents  PLoS One  2012  7(8):e42655  PubMed ID: 22916145   DOI: 10.1371/journal.pone.0042655
8206  Matsubara S, Takahashi T, Kimura AP.  Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression.  Gene  2010  465:17-29  PubMed ID: 20600704   DOI: 10.1016/j.gene.2010.06.006
8276  Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y.  Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line.  Biochem. J.  2010  429:53-61  PubMed ID: 20433422   DOI: 10.1042/BJ20100223
15367  Miki T, Iguchi M, Akiba K, Hosono M, Sobue T, Danbara H, Okada N.  Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes  Mol Microbiol  2010  77(4):855-72  PubMed ID: 20545857   DOI: 10.1111/j.1365-2958.2010.07248.x
19099  Shintaro Katayama, Mutsumi Kanamori-Katayama, Kazumi Yamaguchi, Piero Carninci, Yoshihide Hayashizaki  CAGE-TSSchip: promoter-based expression profiling using the 5'-leading label of capped transcripts  Genome Biology  2007  8:R42    DOI: 10.1186/gb-2007-8-3-r42
3356  Kubota, Koichi  A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection.  J Immunol  2006  176:7576-88  PubMed ID: 16751404   DOI: 10.4049/jimmunol.176.12.7576
18467  Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T, Mori M.  Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone  Endocrinology  2006  147(9):4292-302  PubMed ID: 16794015   DOI: 10.1210/en.2006-0116
3336  Kuang M, Liu, S Q, Saijo K, Uchimura E, Huang L, Leong, K W, Lu, M D, Huang, J F, Ohno T  Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity.  Int J Hyperthermia  2005  21:247-57  PubMed ID: 16019851   DOI: 10.1080/02656730500052027
3189  Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S.  Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system.  Stem Cells  2005  23:903-13  PubMed ID: 16043458   DOI: 10.1634/stemcells.2004-0295
9007  Emoto M, Miki M, Sarker AH, Nakamura T, Seki Y, Seki S, Ikeda S.  Structure and transcription promoter activity of mouse flap endonuclease 1 gene: alternative splicing and bidirectional promoter.  Gene  2005  357:47-54  PubMed ID: 15967598   DOI: 10.1016/j.gene.2005.05.009
2705  Kushida S, Peng, B G, Uchimura E, Kuang M, Huang L, Miwa M, Ohno T  A tumour vaccine of fixed tumour fragments in a controlled-release vehicle with cytokines for therapy of hepatoma in mice.  Dig Liver Dis  2004  36:478-85  PubMed ID: 15285528   DOI: 10.1016/j.dld.2004.02.010
19036  Tanaka T, Tomaru Y, Nomura Y, Miura H, Suzuki M, Hayashizaki Y.  Comprehensive search for HNF-1beta-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi  Nucleic Acids Res  2004  32(9):2740-50  PubMed ID: 15148361   DOI: 10.1093/nar/gkh597
18639  Tomaru Y, Kondo S, Suzuki M, Hayashizaki Y.  A comprehensive search for HNF-3alpha-regulated genes in mouse hepatoma cells by 60K cDNA microarray and chromatin immunoprecipitation/PCR analysis  Biochem Biophys Res Commun  2003  310(2):667-74  PubMed ID: 14521963   DOI: 10.1016/j.bbrc.2003.08.148
2637  Kasahara M, Watanabe Y, Sumasu M, Nagata T  A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.  Proc Natl Acad Sci U S A  2002  99:13687-92  PubMed ID: 12370446   DOI: 10.1073/pnas.212375299
2519  Zhang BN, Watanabe S, Kohyama M, Saijo K, Kusakabe M, Ohno T.  Tumor formation suppressed in gammadeltaT knock-out mice.  Cancer Lett  2000  153(1-2):63-6  PubMed ID: 10779631   DOI: 10.1016/s0304-3835(00)00343-8


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