CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1638 : Hepa 1-6]

2494 Darlington, G J, Bernhard, H P, Miller, R A, Ruddle, F H Expression of liver phenotypes in cultured mouse hepatoma cells. J Natl Cancer Inst 1980 64:809-19 PubMed ID: 6102619

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19711 Asahi T, Abe S, Cui G, Shimba A, Nabekura T, Miyachi H, Kitano S, Ohira K, Dijkstra JM, Miyazaki M, Shibuya A, Ohno H, Ikuta K. Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches Elife 2023 12:e84209 PubMed ID: 37352115 DOI: 10.7554/eLife.84209

21433 Sadakane H, Matsumura M, Murakami M, Itoyama E, Shimokawa F, Sakota S, Yoshioka H, Kawabata H, Matsui T, Funaba M. Weak response of bovine hepcidin induction to iron through decreased expression of Smad4. FASEB J 2023 37(11):e23243 PubMed ID: 37800888 DOI: 10.1096/fj.202301186RR

21450 Sato J, Satoh Y, Yamamoto T, Watanabe T, Matsubara S, Satake H, Kimura AP. PTBP2 binds to a testis-specific long noncoding RNA, Tesra, and activates transcription of the Prss42/Tessp-2 gene. Gene 2023 893:147907 PubMed ID: 37858745 DOI: 10.1016/j.gene.2023.147907

21511 Tominaga S, Yoshioka H, Yokota S, Tsukiboshi Y, Suzui M, Nagai M, Hara H, Maeda T, Miura N. Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice. Environ Health Prev Med 2023 28:78 PubMed ID: 38092388 DOI: 10.1265/ehpm.23-00205

17702 Homma T, Kobayashi S, Fujii J. Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in F Cells 2022 11(10):1603 PubMed ID: 35626640 DOI: 10.3390/cells11101603

17704 Homma T, Osaki T, Kobayashi S, Sato H, Fujii J. d-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione J Clin Biochem Nutr 2022 71(1):48-54 PubMed ID: 35903611 DOI: 10.3164/jcbn.21-143

18222 Homma T, Nishino Y, Fujii J, Yokoyama C. Flow cytometric determination of ferroptosis using a rat monoclonal antibody raised against ferroptotic cells J Immunol Methods 2022 510:113358 PubMed ID: 36126779 DOI: 10.1016/j.jim.2022.113358

20637 Tagawa R, Kobayashi M, Sakurai M, Yoshida M, Kaneko H, Mizunoe Y, Nozaki Y, Okita N, Sudo Y, Higami Y. Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids. Int J Mol Sci 2022 23(3) PubMed ID: 35163722 DOI: 10.3390/ijms23031793

20950 Yoshioka H, Tominaga S, Suzui M, Shinohara Y, Maeda T, Miura N. Involvement of Npas2 and Per2 modifications in zinc-induced acute diurnal toxicity in mice. J Toxicol Sci 2022 47(12):547-553 PubMed ID: 36450499 DOI: 10.2131/jts.47.547

21002 Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J. Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes. iScience 2022 25(12):105662 PubMed ID: 36505926 DOI: 10.1016/j.isci.2022.105662

13346 Kobayashi S, Harada Y, Homma T, Yokoyama C, Fujii J. Characterization of a rat monoclonal antibody raised against ferroptotic cells. J Immunol Methods 2021 PubMed ID: 33189725 DOI: 10.1016/j.jim.2020.112912

20021 Homma T, Kobayashi S, Sato H, Fujii J. Superoxide produced by mitochondrial complex III plays a pivotal role in the execution of ferroptosis induced by cysteine starvation. Arch Biochem Biophys 2021 700:108775 PubMed ID: 33493440 DOI: 10.1016/j.abb.2021.108775

20131 Siswanto FM, Oguro A, Imaoka S. Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2. J Biol Chem 2021 100704 PubMed ID: 33895141 DOI: 10.1016/j.jbc.2021.100704

20245 Homma T, Kobayashi S, Conrad M, Konno H, Yokoyama C, Fujii J. Nitric oxide protects against ferroptosis by aborting the lipid peroxidation chain reaction. Nitric Oxide 2021 115:34-43 PubMed ID: 34329739 DOI: 10.1016/j.niox.2021.07.003

20279 Une N, Takano-Kasuya M, Kitamura N, Ohta M, Inose T, Kato C, Nishimura R, Tada H, Miyagi S, Ishida T, Unno M, Kamei T, Gonda K. The anti-angiogenic agent lenvatinib induces tumor vessel normalization and enhances radiosensitivity in hepatocellular tumors. Med Oncol 2021 38(6):60 PubMed ID: 33881631 DOI: 10.1007/s12032-021-01503-z

11821 Saparbay J, Tanaka Y, Tanimine N, Ohira M, Ohdan H. Everolimus enhances TRAIL-mediated anti-tumor activity of liver resident natural killer cells in mice. Transpl. Int. 2020 33(2):229-243 PubMed ID: 31560810 DOI: 10.1111/tri.13536

6951 Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T4, Otani T5, Takeuchi H6, Jimi E7, Hirata M8. GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin. J Endocrinol 2020 PubMed ID: 31693486 DOI: 10.1530/JOE-19-0288

11951 Liew LC, Gailhouste L, Tan GC, Yamamoto Y, Takeshita F, Nakagama H, Ochiya T. MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells. Stem Cells 2020 PubMed ID: 31828873 DOI: 10.1002/stem.3136

12082 Kobayashi S, Ikeda Y, Shigeno Y, Konno H, Fujii J. γ-Glutamylcysteine synthetase and γ-glutamyl transferase as differential enzymatic sources of γ-glutamylpeptides in mice. Amino Acids 2020 PubMed ID: 32170467 DOI: 10.1007/s00726-020-02835-2

12116 Noguchi T, Ikeda M, Murakami M, Masuzawa M, Imamura T, Hashimoto O, Matsui T, Funaba M. Regulatory expression of bone morphogenetic protein 6 by 2,2'-dipyridyl. Biochim Biophys Acta Gen Subj 2020 PubMed ID: 32251709 DOI: 10.1016/j.bbagen.2020.129610

13036 Tanaka M, Sato A, Kishimoto Y, Mabashi-Asazuma H, Kondo K, Iida K. Gallic Acid Inhibits Lipid Accumulation via AMPK Pathway and Suppresses Apoptosis and Macrophage-Mediated Inflammation in Hepatocytes. Nutrients 2020 PubMed ID: 32443660 DOI: 10.3390/nu12051479

13060 Mayama S, Hamazaki N, Maruyama Y, Matsubara S, Kimura AP. Transcriptional activation of the mouse Scd2 gene by interdependent enhancers and long noncoding RNAs in ovarian granulosa cells. J Reprod Dev 2020 PubMed ID: 32507774 DOI: 10.1262/jrd.2019-161

13073 Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T. Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling. Free Radic Biol Med 2020 PubMed ID: 32553752 DOI: 10.1016/j.freeradbiomed.2020.06.005

13090 Homma T, Kobayashi S, Fujii J. Cysteine preservation confers resistance to glutathione-depleted cells against ferroptosis via CDGSH iron sulphur domain-containing proteins (CISDs). Free Radic Res 2020 PubMed ID: 32605459 DOI: 10.1080/10715762.2020.1780229

13566 Kim DH, Sadakane H, Nishikiori Y, Matsumura M, Ikeda M, Diao Z, Jha R, Murakami M, Matsui T, Funaba M. Factors affecting expression and transcription of uncoupling protein 2 gene J Vet Med Sci 2020 82(12):1734-1741 PubMed ID: 33162463 DOI: 10.1292/jvms.20-0444

14835 Yamada T, Tateishi R, Iwai M, Koike K, Todo T. Neoadjuvant Use of Oncolytic Herpes Virus G47Δ Enhances the Antitumor Efficacy of Radiofrequency Ablation Mol Ther Oncolytics 2020 18:535-54 PubMed ID: 32995479 DOI: 10.1016/j.omto.2020.08.010

11550 Shigeto H, Ono T, Ikeda T, Hirota R, Ishida T, Kuroda A, Funabashi H. Insulin sensor cells for the analysis of insulin secretion responses in single living pancreatic β cells. Analyst 2019 PubMed ID: 31089611 DOI: 10.1039/c9an00405j

11603 Aoki N, Matsui Y. Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells. Mol. Cell. Biol. 2019 PubMed ID: 31208979 DOI: 10.1128/MCB.00154-19

11769 Homma T, Kobayashi S, Fujii J. Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 31445701 DOI: 10.1016/j.bbrc.2019.08.073

11782 Homma T, Kobayashi S, Sato H, Fujii J. Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro. Exp. Cell Res. 2019 PubMed ID: 31479686 DOI: 10.1016/j.yexcr.2019.111592

9192 Toru Suzuki, Chisato Kikuguchi, Saori Nishijima, Takeshi Nagashima, Akinori Takahashi, Mariko Okada, Tadashi Yamamoto Postnatal Liver Functional Maturation Requires Cnot Complex-Mediated Decay of mRNAs Encoding Cell Cycle and Immature Liver Genes Development 2019 146 (4) PubMed ID: 30733279 DOI: 10.1242/dev.168146

10525 Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y. Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways. Redox Biol 2018 15:115-124 PubMed ID: 29241092 DOI: 10.1016/j.redox.2017.09.007

10795 Matsushita J, Okamura K, Nakabayashi K, Suzuki T, Horibe Y, Kawai T, Sakurai T, Yamashita S, Higami Y, Ichihara G, Hata K, Nohara K. The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes. BMC Cancer 2018 18:317 PubMed ID: 29566670 DOI: 10.1186/s12885-018-4221-0

11103 Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S. Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function. Sci Rep 2018 8(1):9072 PubMed ID: 29899468 DOI: 10.1038/s41598-018-27280-w

11100 Nakano R, Ohira M, Yano T, Imaoka Y, Tanaka Y, Ohdan H. Hepatic irradiation persistently eliminates liver resident NK cells. PLoS ONE 2018 13(6):e0198904 PubMed ID: 29897952 DOI: 10.1371/journal.pone.0198904

11157 Germond A, Ichimura T, Chiu LD, Fujita K, Watanabe TM, Fujita H. Cell type discrimination based on image features of molecular component distribution. Sci Rep 2018 8(1):11726 PubMed ID: 30082723 DOI: 10.1038/s41598-018-30276-1

4217 Shinto S, Matsuoka Y, Yamato M, Yamada KI. Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death. J Clin Biochem Nutr 2018 PubMed ID: 29610552 DOI: 10.3164/jcbn.17-60

10033 Nishihara M, Kanda GN, Suzuki T, Yamakado S, Harashima H, Kamiya H. Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase. J. Biosci. Bioeng. 2017 123:277-280 PubMed ID: 27746157 DOI: 10.1016/j.jbiosc.2016.09.008

10211 Fujita K, Iguchi Y, Une M, Watanabe S. Ursodeoxycholic Acid Suppresses Lipogenesis in Mouse Liver: Possible Role of the Decrease in β-Muricholic Acid, a Farnesoid X Receptor Antagonist. Lipids 2017 52:335-344 PubMed ID: 28315136 DOI: 10.1007/s11745-017-4242-5

10364 Lee J, Homma T, Fujii J. Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress. Toxicol. Lett. 2017 277:92-103 PubMed ID: 28642009 DOI: 10.1016/j.toxlet.2017.06.005

10583 Lee J, Kang ES, Kobayashi S, Homma T, Sato H, Seo HG, Fujii J. The viability of primary hepatocytes is maintained under a low cysteine-glutathione redox state with a marked elevation in ophthalmic acid production. Exp. Cell Res. 2017 361:178-191 PubMed ID: 29079265 DOI: 10.1016/j.yexcr.2017.10.017

7067 Yamada K, Mito F, Matsuoka Y, Ide S, Shikimachi K, Fujiki A, Kusakabe D, Ishida Y, Enoki M, Tada A, Ariyoshi M, Yamasaki T, Yamato M. Fluorescence probes to detect lipid-derived radicals. Nat. Chem. Biol. 2016 12:608-13 PubMed ID: 27294322 DOI: 10.1038/nchembio.2105

9733 Takahashi T, Sugawara W, Takiguchi Y, Takizawa K, Nakabayashi A, Nakamura M, Nagano-Ito M, Ichikawa S. Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells. Evid Based Complement Alternat Med 2016 2016:4282758 PubMed ID: 27429636 DOI: 10.1155/2016/4282758

12291 Saneyuki Ujino, Hironori Nishitsuji, Takayuki Hishiki, Kazuo Sugiyama, Hiroshi Takaku, Kunitada Shimotohno Hepatitis C virus utilizes VLDLR as a novel entry pathway Proc Natl Acad Sci U S A 2016 113(1):188-93 PubMed ID: 26699506 DOI: 10.1073/pnas.1506524113

14124 Kobayashi M, Suzuki M, Ohno T, Tsuzuki K, Taguchi C, Tateishi S, Kawada T, Kim YI, Murai A, Horio F. Detection of differentially expressed candidate genes for a fatty liver QTL on mouse chromosome 12 BMC Genet 2016 17(1):73 PubMed ID: 27266874 DOI: 10.1186/s12863-016-0385-2

7330 Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, Araki N, Arai H, Ueda N. Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES. J. Biol. Chem. 2015 290:17520-34 PubMed ID: 26018079 DOI: 10.1074/jbc.M114.635433

7395 Mutai H, Miya F, Fujii M, Tsunoda T, Matsunaga T. Attenuation of progressive hearing loss in DBA/2J mice by reagents that affect epigenetic modifications is associated with up-regulation of the zinc importer Zip4. PLoS ONE 2015 10:e0124301 PubMed ID: 25875282 DOI: 10.1371/journal.pone.0124301

15811 Ichi I, Kono N, Arita Y, Haga S, Arisawa K, Yamano M, Nagase M, Fujiwara Y, Arai H. Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency Biochim Biophys Acta 2014 1841(1):204-13 PubMed ID: 24184513 DOI: 10.1016/j.bbalip.2013.10.013

15913 Kurihara M, Shiraishi A, Satake H, Kimura AP. A conserved noncoding sequence can function as a spermatocyte-specific enhancer and a bidirectional promoter for a ubiquitously expressed gene and a testis-specific long noncoding RNA J Mol Biol 2014 426(17):3069-93 PubMed ID: 25020229 DOI: 10.1016/j.jmb.2014.06.018

18997 Akihiro Deguchi GnT V-Catalyzed N-glycan Products are not increased in Hepatomas Journal of Glycomics & Lipidomics 2013 01 DOI: 10.4172/2153-0637.s5-003

19073 Kawahara T, Toso C, Yamaguchi K, Cader S, Douglas DN, Nourbakhsh M, Lewis JT, Churchill TA, Yagita H, Kneteman NM. Additive effect of sirolimus and anti-death receptor 5 agonistic antibody against hepatocellular carcinoma Liver Int 2013 33(9):1441-8 PubMed ID: 23895107 DOI: 10.1111/liv.12275

15764 Burdeos GC, Nakagawa K, Watanabe A, Kimura F, Miyazawa T. γ-Tocotrienol attenuates triglyceride through effect on lipogenic gene expressions in mouse hepatocellular carcinoma Hepa 1-6 J Nutr Sci Vitaminol (Tokyo) 2013 59(2):148-51 PubMed ID: 23727646 DOI: 10.3177/jnsv.59.148

18568 Kimura T, Yoshida K, Yamamoto C, Suzuki M, Uno T, Isobe M, Naka H, Yasuike S, Satoh M, Kaji T, Uchiyama M. Bis(L-cysteinato)zincate(lI) as a coordination compound that induces metallothionein gene transcription without inducing cell-stress-related gene transcription J Inorg Biochem 2012 117:140-6 PubMed ID: 23085594 DOI: 10.1016/j.jinorgbio.2012.07.021

13154 Hideaki Yamamoto, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira Enhanced liver functions in mouse hepatoma cells by induced overexpression of liver-enriched transcription factor Biochemical Engineering Journal 2012 60:67-73 DOI: 10.1016/j.bej.2011.10.004

15762 Hamasaki T, Suzuki H, Shirohzu H, Matsumoto T, D'Alessandro-Gabazza CN, Gil-Bernabe P, Boveda-Ruiz D, Naito M, Kobayashi T, Toda M, Mizutani T, Taguchi O, Morser J, Eguchi Y, Kuroda M, Ochiya T, Hayashi H, Gabazza EC, Ohgi T. Efficacy of a novel class of RNA interference therapeutic agents PLoS One 2012 7(8):e42655 PubMed ID: 22916145 DOI: 10.1371/journal.pone.0042655

8206 Matsubara S, Takahashi T, Kimura AP. Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression. Gene 2010 465:17-29 PubMed ID: 20600704 DOI: 10.1016/j.gene.2010.06.006

8276 Miyayama T, Hiraoka D, Kawaji F, Nakamura E, Suzuki N, Ogra Y. Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line. Biochem. J. 2010 429:53-61 PubMed ID: 20433422 DOI: 10.1042/BJ20100223

15367 Miki T, Iguchi M, Akiba K, Hosono M, Sobue T, Danbara H, Okada N. Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes Mol Microbiol 2010 77(4):855-72 PubMed ID: 20545857 DOI: 10.1111/j.1365-2958.2010.07248.x

19099 Shintaro Katayama, Mutsumi Kanamori-Katayama, Kazumi Yamaguchi, Piero Carninci, Yoshihide Hayashizaki CAGE-TSSchip: promoter-based expression profiling using the 5'-leading label of capped transcripts Genome Biology 2007 8:R42 DOI: 10.1186/gb-2007-8-3-r42

3356 Kubota, Koichi A novel functional T cell hybridoma recognizes macrophage cell death induced by bacteria: a possible role for innate lymphocytes in bacterial infection. J Immunol 2006 176:7576-88 PubMed ID: 16751404 DOI: 10.4049/jimmunol.176.12.7576

18467 Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T, Mori M. Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone Endocrinology 2006 147(9):4292-302 PubMed ID: 16794015 DOI: 10.1210/en.2006-0116

3336 Kuang M, Liu, S Q, Saijo K, Uchimura E, Huang L, Leong, K W, Lu, M D, Huang, J F, Ohno T Microwave tumour coagulation plus in situ treatment with cytokine-microparticles: induction of potent anti-residual tumour immunity. Int J Hyperthermia 2005 21:247-57 PubMed ID: 16019851 DOI: 10.1080/02656730500052027

3189 Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S. Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system. Stem Cells 2005 23:903-13 PubMed ID: 16043458 DOI: 10.1634/stemcells.2004-0295

9007 Emoto M, Miki M, Sarker AH, Nakamura T, Seki Y, Seki S, Ikeda S. Structure and transcription promoter activity of mouse flap endonuclease 1 gene: alternative splicing and bidirectional promoter. Gene 2005 357:47-54 PubMed ID: 15967598 DOI: 10.1016/j.gene.2005.05.009

2705 Kushida S, Peng, B G, Uchimura E, Kuang M, Huang L, Miwa M, Ohno T A tumour vaccine of fixed tumour fragments in a controlled-release vehicle with cytokines for therapy of hepatoma in mice. Dig Liver Dis 2004 36:478-85 PubMed ID: 15285528 DOI: 10.1016/j.dld.2004.02.010

19036 Tanaka T, Tomaru Y, Nomura Y, Miura H, Suzuki M, Hayashizaki Y. Comprehensive search for HNF-1beta-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi Nucleic Acids Res 2004 32(9):2740-50 PubMed ID: 15148361 DOI: 10.1093/nar/gkh597

18639 Tomaru Y, Kondo S, Suzuki M, Hayashizaki Y. A comprehensive search for HNF-3alpha-regulated genes in mouse hepatoma cells by 60K cDNA microarray and chromatin immunoprecipitation/PCR analysis Biochem Biophys Res Commun 2003 310(2):667-74 PubMed ID: 14521963 DOI: 10.1016/j.bbrc.2003.08.148

2637 Kasahara M, Watanabe Y, Sumasu M, Nagata T A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Proc Natl Acad Sci U S A 2002 99:13687-92 PubMed ID: 12370446 DOI: 10.1073/pnas.212375299

2519 Zhang BN, Watanabe S, Kohyama M, Saijo K, Kusakabe M, Ohno T. Tumor formation suppressed in gammadeltaT knock-out mice. Cancer Lett 2000 153(1-2):63-6 PubMed ID: 10779631 DOI: 10.1016/s0304-3835(00)00343-8