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細胞番号 : 細胞名
RCB1637 : 293  update : 2024/11/22
細胞特性(Comment:英)A human cell line derived from kidney of a fetus. Transformed with sheared human Ad5 DNA. Sensitive to human adenoviruses and adenovirus DNA. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 85120602 prior to order.
細胞特性(日)ヒト胎児腎臓由来細胞株。アデノウイルス5型による形質転換株。HEK293細胞ともいう。ECACC由来株。使用条件等がECACCによって随時変更となる可能性があります。ご購入前に、ECACC 85120602 を必ずご参照ください。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85120602 prior to order.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。しかし、使用条件等がECACCによって随時変更となる可能性があるので、購入前に、ECA85120602 を必ず参照すること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 2000
別名 HEK293
動物種 _human < Mammals
属名 Homo
種名 sapiens
embryo
採取組織 kidney
細胞分類 transformed
入手歴 overseas, ECACC -> Riken cell bank
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0045
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS + 0.1mM NEAA
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
動物種PCR OK
染色体検査 63-71(50) : /65(5),66(5),67(8),68(10),69(10),70(8)/
個体識別検査 OK
文献情報 Reference(英) 3件
Reference(日) 0件
利用者成果(英) 338件
利用者成果(日) 2件

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Reference(英)
4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220   DOI: 10.1016/0042-6822(78)90003-x
2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862   DOI: 10.1016/0042-6822(77)90428-7
2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304   DOI: 10.1099/0022-1317-36-1-59

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Reference(日)

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利用者成果(英)
19831  Yamaguchi F, Sakane H, Akasaki K.  Comparative study of the steady-state subcellular distribution of lysosome-associated membrane glycoprotein-2 (LAMP-2) isoforms with GYXXΦ-type tyrosine-based motifs that interact differently with four adaptor protein (AP) complexes  J Biochem  2024  175(3):275-287  PubMed ID: 37983719   DOI: 10.1093/jb/mvad096
19873  Kataoka H, Akiyoshi T, Uchida Y, Imaoka A, Terasaki T, Ohtani H.  The effects of N-glycosylation on the expression and transport activity of OATP1A2 and OATP2B1  J Pharm Sci  2024  S0022-3549(24)00058-3  PubMed ID: 38432624   DOI: 10.1016/j.xphs.2024.02.012
19956  Mixich L, Boonstra E, Masuda K, Li SW, Nakashima Y, Meng F, Sakata M, Goda T, Uchida S, Cabral H.  Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo  Biomacromolecules  2024  Jan 5  PubMed ID: 38181450   DOI: 10.1021/acs.biomac.3c01102
21560  Wang A, Uchida K, Yokoyama A, Higashino F, Yasuda M.  Human adenovirus oncolytic properties and the inhibitory role of E4 orf4 and E4 orf6/7 on endogenously activated NF-κB.  Biochem Biophys Rep  2024  37:101616  PubMed ID: 38205184   DOI: 10.1016/j.bbrep.2023.101616
21700  Katayama K, Ito J, Murakami R, Yamashita A, Sasajima H, Narahashi S, Chiba J, Yamamoto I, Fujii W, Tochigi Y, Suzuki H.  Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.  Mamm Genome  2024    PubMed ID: 38658415   DOI: 10.1007/s00335-024-10041-8
21741  Kato S, Tamura K, Masuda Y, Konishi M, Yamanaka K, Oikawa T.  A novel type IIb L-asparaginase from Latilactobacillus sakei LK-145: characterization and application.  Arch Microbiol  2024  206(6):266  PubMed ID: 38761213   DOI: 10.1007/s00203-024-03979-5
21778  Imamura I, Kiyama R.  Potential involvement of KANK1 haploinsufficiency in centrosome aberrations.  Biochim Biophys Acta Gen Subj  2024  130648  PubMed ID: 38830559   DOI: 10.1016/j.bbagen.2024.130648
21794  Zhou J, Murata H, Tomonobu N, Mizuta N, Yamakawa A, Yamamoto KI, Kinoshita R, Sakaguchi M.  S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway.  In Vitro Cell Dev Biol Anim  2024    PubMed ID: 38842658   DOI: 10.1007/s11626-024-00930-2
21796  Hara Y, Ichiraku A, Matsuda T, Sakane A, Sasaki T, Nagai T, Horikawa K.  High-affinity tuning of single fluorescent protein-type indicators by flexible linker length optimization in topology mutant.  Commun Biol  2024    PubMed ID: 38851844   DOI: 10.1038/s42003-024-06394-0
21798  Ichiyama-Kobayashi S, Hata K, Wakamori K, Takahata Y, Murakami T, Yamanaka H, Takano H, Yao R, Uzawa N, Nishimura R.  Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development.  JCI Insight  2024  9(11)  PubMed ID: 38855864   DOI: 10.1172/jci.insight.175486
21799  Yamamoto R, Segawa R, Kato H, Niino Y, Sato T, Hiratsuka M, Hirasawa N.  Identification of amino acids in transmembrane domains of mutated cytokine receptor-like factor 2 and interleukin-7 receptor α required for constitutive signal transduction.  Biochim Biophys Acta Biomembr  2024  184359  PubMed ID: 38862034   DOI: 10.1016/j.bbamem.2024.184359
21837  Maruyama Y, Ohsawa Y, Suzuki T, Yamauchi Y, Ohno K, Inoue H, Yamamoto A, Hayashi M, Okuhara Y, Muramatsu W, Namiki K, Hagiwara N, Miyauchi M, Miyao T, Ishikawa T, Horie K, Hayama M, Akiyama N, Hirokawa T, Akiyama T.  Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist.  Nat Commun  2024  15(1):5743  PubMed ID: 39030171   DOI: 10.1038/s41467-024-49893-8
21962  Okamoto Y, Kitakaze K, Takenouchi Y, Matsui R, Koga D, Miyashima R, Ishimaru H, Tsuboi K.  GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.  Biochim Biophys Acta Mol Cell Res  2024  1871(7):119798  PubMed ID: 39047914   DOI: 10.1016/j.bbamcr.2024.119798
22008  Kawaue H, Matsubara T, Nagano K, Ikedo A, Rojasawasthien T, Yoshimura A, Nakatomi C, Imai Y, Kakuta Y, Addison WN, Kokabu S.  KIF22 regulates mitosis and proliferation of chondrocyte cells.  iScience  2024  27(7):110151  PubMed ID: 38989461   DOI: 10.1016/j.isci.2024.110151
22009  Ishizawa M, Takano M, Kittaka A, Matsumoto T, Makishima M.  2α-Substituted Vitamin D Derivatives Effectively Enhance the Osteoblast Differentiation of Dedifferentiated Fat Cells.  Biomolecules  2024  14(6)  PubMed ID: 38927109   DOI: 10.3390/biom14060706
22068  Kato S, Deguchi K, Obana M, Fujio Y, Fukuda Y, Inoue T.  Metabolite phosphatase from anhydrobiotic tardigrades.  FEBS J  2024    PubMed ID: 39417615   DOI: 10.1111/febs.17296
22088  Oyama S, Zhang H, Ferdous R, Tomochika Y, Chen B, Jiang S, Islam MS, Hasan MM, Zhai Q, Waliullah ASM, Ping Y, Yan J, Mimi MA, Zhang C, Aramaki S, Takanashi Y, Kahyo T, Hashizume Y, Kaneda D, Setou M.  UBL3 Interacts with PolyQ-Expanded Huntingtin Fragments and Modifies Their Intracellular Sorting.  Neurol Int  2024  16(6):1175-1188  PubMed ID: 39449505   DOI: 10.3390/neurolint16060089
22131  Kawataki S, Kubota Y, Katayama K, Imoto S, Takekawa M.  GADD45β-MTK1 signaling axis mediates oncogenic stress-induced activation of the p38 and JNK pathways.  Cancer Sci  2024    PubMed ID: 39526327   DOI: 10.1111/cas.16389
22236  Lin N, Miyamoto K, Ogawara T, Sakurai S, Kizaka-Kondoh S, Kadonosono T.  Epitope binning for multiple antibodies simultaneously using mammalian cell display and DNA sequencing  Commun Biol  2024  7(1):652  PubMed ID: 38806676   DOI: 10.1038/s42003-024-06363-7
22237  Mubuchi A, Takechi M, Nishio S, Matsuda T, Itoh Y, Sato C, Kitajima K, Kitagawa H, Miyata S.  Assembly of neuron- and radial glial-cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons  Elife  2024  12:RP92342  PubMed ID: 38512724   DOI: 10.7554/eLife.92342
17776  Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H.  Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels  BMC Cancer  2023  23(1):356  PubMed ID: 37072777   DOI: 10.1186/s12885-023-10845-y
17778  Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai  Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα  Drug Metabolism and Pharmacokinetics  2023      DOI: 10.1016/j.dmpk.2023.100512
19535  Yan J, Zhang H, Tomochika Y, Chen B, Ping Y, Islam MS, Aramaki S, Sato T, Nagashima Y, Nakamura T, Kahyo T, Kaneda D, Ogawa K, Yoshida M, Setou M.  UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3  Biomedicines  2023  11(9):2491  PubMed ID: 37760932   DOI: 10.3390/biomedicines11092491
19666  Aso A, Nabetani H, Matsuura Y, Kadonaga Y, Shirakami Y, Watabe T, Yoshiya T, Mochizuki M, Ooe K, Kawakami A, Jinno N, Toyoshima A, Haba H, Wang Y, Cardinale J, Giesel FL, Shimoyama A, Kaneda-Nakashima K, Fukase K.  Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine  Int J Mol Sci  2023  24(10):8701  PubMed ID: 37240044   DOI: 10.3390/ijms24108701
19686  Takeuchi M, Nishisho T, Toki S, Kawaguchi S, Tamaki S, Oya T, Uto Y, Katagiri T, Sairyo K.  Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondr  Cancer Med  2023  12(8):9668-9683  PubMed ID: 36722116   DOI: 10.1002/cam4.5664
19701  Yamamoto R, Segawa R, Liu J, Isaji T, Gu J, Hiratsuka M, Hirasawa N.  Effect of N-glycosylation on constitutive signal transduction by mutated cytokine receptor-like factor 2  Biochim Biophys Acta Gen Subj  2023  1867(11):130465  PubMed ID: 37748663   DOI: 10.1016/j.bbagen.2023.130465
19785  Yamamoto H, Tanaka Y, Sawada M, Kihara S.  ERRα Attenuates Vascular Inflammation via Enhanced NFκB Degradation Pathway  Endocrinology  2023  164(3):bqac212  PubMed ID: 36534970   DOI: 10.1210/endocr/bqac212
19803  Murase W, Kubota A, Ikeda-Araki A, Terasaki M, Nakagawa K, Shizu R, Yoshinari K, Kojima H.  Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays  Toxicology  2023  494:153577  PubMed ID: 37302725   DOI: 10.1016/j.tox.2023.153577
19809  Tezuka M, Yonekubo-Awaka S, Tamai Y, Tsuchioka K, Kobayashi K, Kuramochi Y, Tatemichi S, Nagasawa T, Kiguchi S.  Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models  Clin Exp Pharmacol Physiol  2023  50(11):914-923  PubMed ID: 37622483   DOI: 10.1111/1440-1681.13817
19876  Maekawa K, Ishizawa M, Ikawa T, Sajiki H, Matsumoto T, Tokiwa H, Makishima M, Yamada S.  Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D3 Derivatives with Structure-Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs  Biomolecules  2023  13(7):1082  PubMed ID: 37509118   DOI: 10.3390/biom13071082
19899  Nakamura T, Sugeno N, Hasegawa T, Ikeda K, Yoshida S, Ishiyama S, Sato K, Takeda A, Aoki M.  Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex  FEBS J  2023  Dec 17  PubMed ID: 38105619   DOI: 10.1111/febs.17037
19947  Moriizumi H, Kubota Y, Tsuchiya T, Naka R, Takekawa M.  Caspase 3-specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress-induced apoptosis  FEBS Open Bio  2023  13(4):684-700  PubMed ID: 36776127   DOI: 10.1002/2211-5463.13574
19987  Miyajima Y, Noguchi-Yachide T, Ochiai K, Fujii S.  Physicochemical characterization of B-hydroxyphenyl phosphine borane derivatives and their evaluation as nuclear estrogen receptor ligands  RSC Med Chem  2023  15(1):119-12  PubMed ID: 38283218   DOI: 10.1039/d3md00350g
21018  Nakashima KI, Okamura M, Matsumoto I, Kameda N, Tsuboi T, Yamaguchi E, Itoh A, Inoue M.  Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator-activated receptor by designed lignans based on natural products in 3T3-L1 cells.  J Nat Med  2023    PubMed ID: 36607539   DOI: 10.1007/s11418-022-01674-7
21023  Nakamura Y, Aizawa C, Kawata H, Nakanishi T.  N-glycosylation Modifies Prostaglandin E2 Uptake by Reducing Cell Surface Expression of SLCO2A1.  Prostaglandins Other Lipid Mediat  2023  106714  PubMed ID: 36706979   DOI: 10.1016/j.prostaglandins.2023.106714
21041  Shiraki A, Shimizu S.  The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor.  Biochem Biophys Res Commun  2023  640:64-72  PubMed ID: 36502633   DOI: 10.1016/j.bbrc.2022.11.098
21068  Yamakado N, Okuda S, Tobiume K, Uetsuki R, Ono S, Mizuta K, Nakagawa T, Aikawa T.  Chemical inhibition of LSD1 leads to epithelial to mesenchymal transition in vitro of an oral squamous cell carcinoma OM-1 cell line via release from LSD1-dependent suppression of ZEB1.  Biochem Biophys Res Commun  2023  647:23-29  PubMed ID: 36709669   DOI: 10.1016/j.bbrc.2023.01.062
21100  Suzuki Y, Nakamoto C, Watanabe-Iida I, Watanabe M, Takeuchi T, Sasaoka T, Abe M, Sakimura K.  Quantitative analysis of NMDA receptor subunits proteins in mouse brain.  Neurochem Int  2023  105517  PubMed ID: 36913980   DOI: 10.1016/j.neuint.2023.105517
21116  Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y.  Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.  Cells  2023  12(4)  PubMed ID: 36831269   DOI: 10.3390/cells12040602
21153  Yang W, Miyazaki T, Nakagawa Y, Boonstra E, Masuda K, Nakashima Y, Chen P, Mixich L, Barthelmes K, Matsumoto A, Mi P, Uchida S, Cabral H.  Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π-π stacking-assisted micellar assembly.  Sci Technol Adv Mater  2023  24(1):2170164  PubMed ID: 36950277   DOI: 10.1080/14686996.2023.2170164
21214  Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H.  Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality.  iScience  2023  26(4):106487  PubMed ID: 37096037   DOI: 10.1016/j.isci.2023.106487
21246  Ishiyama S, Hasegawa T, Sugeno N, Kobayashi J, Yoshida S, Miki Y, Wakabayashi K, Fukuda M, Kawata Y, Nakamura T, Sato K, Ezura M, Kikuchi A, Takeda A, Aoki M.  Sortilin acts as an endocytic receptor for α-synuclein fibril.  FASEB J  2023  37(7):e23017  PubMed ID: 37272890   DOI: 10.1096/fj.202201605RR
21270  Yamaguchi S, Kamino M, Hamamura M, Otsuguro KI.  The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells.  PLoS One  2023  18(6):e0287249  PubMed ID: 37352201   DOI: 10.1371/journal.pone.0287249
21333  Kogaki T, Hase H, Tanimoto M, Tashiro A, Kitae K, Ueda Y, Jingushi K, Tsujikawa K.  ALKBH4 is a novel enzyme that promotes translation through modified uridine regulation.  J Biol Chem  2023  105093  PubMed ID: 37507018   DOI: 10.1016/j.jbc.2023.105093
21384  Nishida K, Wang G, Kobatake E, Mie M.  Sensitive Detection of Tumor Cells Using Protein Nanoparticles with Multiple Displays of DNA Aptamers and Bioluminescent Reporters.  ACS Biomater Sci Eng  2023    PubMed ID: 37642536   DOI: 10.1021/acsbiomaterials.3c00712
21453  Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.  Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.  J Pharmacol Sci  2023  153(3):153-160  PubMed ID: 37770156   DOI: 10.1016/j.jphs.2023.08.008
21467  Suzuki S, Saito S, Narushima Y, Kodani S, Kagaya N, Suenaga H, Shin-Ya K, Arai MA.  Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation.  J Antibiot (Tokyo)  2023    PubMed ID: 37938761   DOI: 10.1038/s41429-023-00673-4
21485  Zhao X, Ma D, Ishiguro K, Saito H, Akichika S, Matsuzawa I, Mito M, Irie T, Ishibashi K, Wakabayashi K, Sakaguchi Y, Yokoyama T, Mishima Y, Shirouzu M, Iwasaki S, Suzuki T, Suzuki T.  Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.  Cell  2023    PubMed ID: 37992713   DOI: 10.1016/j.cell.2023.10.026
21508  Kenji Ohba, Hiroaki Mizukami  Protocol for producing an adeno-associated virus vector by controlling capsid expression timing  STAR Protocols  2023  4:102542  PubMed ID: 38103199   DOI: 10.1016/j.xpro.2023.102542
21534  Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Johnson EL, Harada Y, Tamura JI, Taniguchi N.  Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model.  J Biol Chem  2023  299(8):105052  PubMed ID: 37454739   DOI: 10.1016/j.jbc.2023.105052
17537  Emiko Kinoshita-Kikuta, Yoko Ino, Yayoi Kimura, Tomoko Akiyama, Eiji Kinoshita, Tohru Koike  Use of Escherichia coli expression system for analyzing kinase motifs  Journal of Electrophoresis  2022  66:13-20    DOI: 10.2198/jelectroph.66.13
17583  Han H, Akiyoshi T, Morita T, Kataoka H, Katayama K, Yajima K, Imaoka A, Ohtani H.  Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants  Drug Metab Pharmacokinet  2022  47:100470  PubMed ID: 36116173   DOI: 10.1016/j.dmpk.2022.100470
17609  Yoshihara A, Kawasaki H, Masuno H, Takada K, Numoto N, Ito N, Hirata N, Kanda Y, Ishizawa M, Makishima M, Kagechika H, Tanatani A.  Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists  Biomolecules  2022  12(1):130  PubMed ID: 35053278   DOI: 10.3390/biom12010130
17708  Nakamura Y, Kozakai H, Nishio T, Yoshida K, Nakanishi T.  Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1  Drug Metab Pharmacokinet  2022  44:100452  PubMed ID: 35299026   DOI: 10.1016/j.dmpk.2022.100452
17798  Chen P, Yang W, Hong T, Miyazaki T, Dirisala A, Kataoka K, Cabral H.  Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC  Biomaterials  2022  288:121748  PubMed ID: 36038419   DOI: 10.1016/j.biomaterials.2022.121748
15439  Shams R, Matsukawa A, Ochi Y, Ito Y, Miyatake H.  In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1  J Med Chem  2022  Jun 30  PubMed ID: 34191518   DOI: 10.1021/acs.jmedchem.1c00536
20553  Urabe T, Miyoshi H, Narasaki S, Yanase Y, Uchida K, Noguchi S, Hide M, Tsutsumi YM, Sakai N.  Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic.  PLoS One  2022  17(2):e0263395  PubMed ID: 35104283   DOI: 10.1371/journal.pone.0263395
16391  Sakamoto T, Yu Z, Otani Y.  Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells  Anal Chem  2022  Mar 2  PubMed ID: 35234461   DOI: 10.1021/acs.analchem.1c04804
20612  Yamatoya K, Nagai Y, Teramoto N, Kang W, Miyado K, Nakata K, Yagi T, Miyamoto Y.  Cryopreservation of undifferentiated and differentiated human neuronal cells.  Regen Ther  2022  19:58-68  PubMed ID: 35059480   DOI: 10.1016/j.reth.2021.12.007
20616  Liu JY, Inoshita T, Shiba-Fukushima K, Yoshida S, Ogata K, Ishihama Y, Imai Y, Hattori N.  Ubiquitination at the lysine 27 residue of the parkin ubiquitin-like domain is suggestive of a new mechanism of parkin activation.  Hum Mol Genet  2022    PubMed ID: 35313349   DOI: 10.1093/hmg/ddac064
20649  Liu Y, Nisisako T.  Microfluidic generation of monodispersed Janus alginate hydrogel microparticles using water-in-oil emulsion reactant.  Biomicrofluidics  2022  16(2):024101  PubMed ID: 35282035   DOI: 10.1063/5.0077916
20657  Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y.  Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.  Biochem Biophys Rep  2022  29:101223  PubMed ID: 35146136   DOI: 10.1016/j.bbrep.2022.101223
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6236  Xu H, Shen Z, Xiao J, Yang Y, Huang W, Zhou Z, Shen J, Zhu Y1, Liu XY, Chu L.  Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect.  BMC Cancer  2014  14:668  PubMed ID: 25220382   DOI: 10.1186/1471-2407-14-668
3443  Shimizu S, Yonezawa R, Hagiwara T, Yoshida T, Takahashi N, Hamano S, Negoro T, Toda T, Wakamori M, Mori Y, Ishii M.  Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry.  Eur J Pharmacol  2014  742:22-30  PubMed ID: 25179574   DOI: 10.1016/j.ejphar.2014.08.023
9113  Mutsuyo Takayama-Ito, Kazuo Nakamichi, Hitomi Kinoshita, Satsuki Kakiuchi, Ichiro Kurane, Masayuki Saijo, Chang-Kweng Lim  A Sensitive in Vitro Assay for the Detection of Residual Viable Rabies Virus in Inactivated Rabies Vaccines  Biologicals  2014  42 (1), 42-7  PubMed ID: 24321529   DOI: 10.1016/j.biologicals.2013.11.003
9475  Kazuhiro Shiozaki, Sena Ryuzono, Naoto Matsushita, Asami Ikeda, Kazuki Takeshita, Petros Kingstone Chigwechokha, Masaharu Komatsu, Taeko Miyagi  Molecular Cloning and Biochemical Characterization of Medaka (Oryzias Latipes) Lysosomal neu4 Sialidase  Fish Physiol Biochemc  2014  40(5):1461-72  PubMed ID: 24744226   DOI: 10.1007/s10695-014-9940-9
9478  Petros Kingstone Chigwechokha, Masaharu Komatsu, Takao Itakura, Kazuhiro Shiozaki  Nile Tilapia Neu3 Sialidases: Molecular Cloning, Functional Characterization and Expression in Oreochromis Niloticus  Gene  2014  552(1):155-64  PubMed ID: 25234733   DOI: 10.1016/j.gene.2014.09.029
15322  Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H.  Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene  J Nat Prod  2014  77(7):1670-7  PubMed ID: 24959987   DOI: 10.1021/np5002016
15820  Takeuchi T, Kubo Y, Okano K, Okano T.  Identification and characterization of cryptochrome4 in the ovary of western clawed frog Xenopus tropicalis  Zoolog Sci  2014  31(3):152-9  PubMed ID: 24601777   DOI: 10.2108/zsj.31.152
15910  Wang H, Cai Z, Yang F, Luo J, Satoh M, Arai Y, Li D.  Enhanced antitumor efficacy of integrin-targeted oncolytic adenovirus AxdAdB3-F/RGD on bladder cancer  Urology  2014  83(2):508.e13-9  PubMed ID: 24315309   DOI: 10.1016/j.urology.2013.10.025
15911  Tan C, Takayama T, Takaoka N, Fujita H, Miyazaki M, Sugiyama T, Ozono S.  Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival  Clin Med Insights Oncol  2014  8:21-7  PubMed ID: 24653654   DOI: 10.4137/CMO.S13684
16007  Zhou B, Wei FY, Kanai N, Fujimura A, Kaitsuka T, Tomizawa K.  Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human.  Hum Mol Genet  2014  23(17):4639-50  PubMed ID: 24760768   DOI: 10.1093/hmg/ddu184
18281  Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K.  Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a)  Biochem Biophys Res Commun  2013  441(1):157-63  PubMed ID: 24134843   DOI: 10.1016/j.bbrc.2013.10.020
4392  Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T.  Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes).  Biochimie  2013  95(2):280-9  PubMed ID: 23032629   DOI: 10.1016/j.biochi.2012.09.026
6565  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878   DOI: 10.1002/art.37779
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12710  Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, Kobayashi M, Takeda H.  hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors  PLoS One  2013  8(6):e66255  PubMed ID: 23840432   DOI: 10.1371/journal.pone.0066255
15769  Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, Martelli AM, Topham MK, Iino M, Goto K.  Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity  J Cell Sci  2013  126(Pt 13):2785-97  PubMed ID: 23606744   DOI: 10.1242/jcs.118711
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15927  Togo Y, Takahashi K, Saito K, Kiso H, Huang B, Tsukamoto H, Hyon SH, Bessho K.  Aldehyded Dextran and ε -Poly(L-lysine) Hydrogel as Nonviral Gene Carrier  Stem Cells Int  2013  2013:634379  PubMed ID: 24027586   DOI: 10.1155/2013/634379
15928  Tanaka YT, Tanaka K, Kojima H, Hamada T, Masutani T, Tsuboi M, Akao Y.  Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B  Bioorg Med Chem Lett  2013  23(2):518-23  PubMed ID: 23232059   DOI: 10.1016/j.bmcl.2012.11.034
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15960  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner  Biochem J  2013  450(2):303-9  PubMed ID: 23256752   DOI: 10.1042/BJ20121348
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18699  Nemoto Y, Zhou YM, Tatsumi E, Nakayama Y.  Photoinduced cross-linking of star vector for improvement of gene transfer efficiency  Bioconjug Chem  2008  19(12):2513-9  PubMed ID: 19007107   DOI: 10.1021/bc800003t
19153  Murata T, Shinozuka Y, Obata Y, Yokoyama KK.  Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1  Anal Biochem  2008  376(1):115-21  PubMed ID: 18307971   DOI: 10.1016/j.ab.2008.01.038
4714  Sakurai M, Misawa T, Shiba H, Iida T, Ohashi T, Yanaga K.  A novel approach for gene transduction with adenovirus vector and the fibrin glue system.  Anticancer Res  2008  28(6A):3809-13  PubMed ID: 19189668  
3723  Toyoda E, Doi R, Kami K, Mori T, Ito D, Koizumi M, Kida A, Nagai K, Ito T, Masui T, Wada M, Tagawa M, Uemoto S.  Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer  J Exp Clin Cancer Res  2008  27(1):30  PubMed ID: 18717994   DOI: 10.1186/1756-9966-27-30
3438  Kira Y1, Nishikawa M.  The identification and characterization of a new GTP-binding protein (Gbp45) involved in cell proliferation and death related to mitochondrial function.  Cell Mol Biol Lett  2008  13(4):570-84  PubMed ID: 18536999   DOI: 10.2478/s11658-008-0023-8
6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406   DOI: 10.1172/JCI31373
13805    JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts  J Bone Miner Res  2008  23(6):907-14  PubMed ID: 18251700   DOI: 10.1359/jbmr.080211
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18831  Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site  J Lipid Res  2006  47(6):1146-56  PubMed ID: 16520488   DOI: 10.1194/jlr.M500329-JLR200
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10355  Osamu Hashimoto, Yuuki Ushiro, Kazunari Sekiyama, Osamu Yamaguchi, Kazuki Yoshioka, Ken-ichiro Mutoh, Yoshihisa Hasegawa  Impaired Growth of Pancreatic Exocrine Cells in Transgenic Mice Expressing Human Activin betaE Subunit  Biochem Biophys Res Commun  2006  341(2):416-24  PubMed ID: 16426570   DOI: 10.1016/j.bbrc.2005.12.205
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15483  林 浩之輔, 友添 祐介, 永井 賢治, 松葉 恭一, 三ツ森 正之, 平石 佳之, 松村 外志張, 上田 宏, 神谷 典穂  固相免疫測定を目的とした融合タンパク質試薬の設計とヒト培養細胞による生産プロセスの最適化  化学工学論文集  2015  41:38-42    DOI: 10.1252/kakoronbunshu.41.38
5869  野田頭 達也, 小田桐 弘毅, 池永 照史郎一期, 丸山 将輝, 佐藤 利行, 袴田 健一  Cre/loxP system を用いた HER2/neu 発現細胞に対する特異的かつ効率的遺伝子導入システムの開発  弘前医学  2010  61:26―34    DOI: 10.32216/hirosakiigaku.61.1_26



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