Cell No. : Cell Name RCB1637 : 293  update : 2023/09/27
Comment			A human cell line derived from kidney of a fetus. Transformed with sheared human Ad5 DNA. Sensitive to human adenoviruses and adenovirus DNA. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 85120602 prior to order.
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85120602 prior to order.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	ECACC
		Year of deposit	2000
		Another name	HEK293
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Age at sampling	embryo
		Tissue	kidney
		Classification	transformed
		History	overseas, ECACC -> Riken cell bank
		Lifespan	infinite
		Morphology	epithelial-like
		Cellosaurus(Expasy)	CVCL_0045
			deposit info	lot info
		Medium	Medium List
		Culture type		Adherent cells
		Culture medium		MEM + 10% FBS + 0.1mM NEAA
		Antibiotics		Free
		Passage method		0.25% Trypsin
	Culture information	Passage ratio		1 : 8 split
		SC frequency		Subculture : once/week, Medium Renewal : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma		(-)
		Isozyme		LD, NP
		Chromosome mode		63-71(50) : /65(5),66(5),67(8),68(10),69(10),70(8)/
		STR(human)		OK
Reference information		Reference	3
		User's Publication	285

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Reference

4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220   DOI: 10.1016/0042-6822(78)90003-x

2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862   DOI: 10.1016/0042-6822(77)90428-7

2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304   DOI: 10.1099/0022-1317-36-1-59

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User's Publication

17776  Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H.  Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels  BMC Cancer  2023  23(1):356  PubMed ID: 37072777   DOI: 10.1186/s12885-023-10845-y

17778  Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai  Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα  Drug Metabolism and Pharmacokinetics  2023      DOI: 10.1016/j.dmpk.2023.100512

21018  Nakashima KI, Okamura M, Matsumoto I, Kameda N, Tsuboi T, Yamaguchi E, Itoh A, Inoue M.  Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator-activated receptor by designed lignans based on natural products in 3T3-L1 cells.  J Nat Med  2023    PubMed ID: 36607539   DOI: 10.1007/s11418-022-01674-7

21023  Nakamura Y, Aizawa C, Kawata H, Nakanishi T.  N-glycosylation Modifies Prostaglandin E2 Uptake by Reducing Cell Surface Expression of SLCO2A1.  Prostaglandins Other Lipid Mediat  2023  106714  PubMed ID: 36706979   DOI: 10.1016/j.prostaglandins.2023.106714

21041  Shiraki A, Shimizu S.  The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor.  Biochem Biophys Res Commun  2023  640:64-72  PubMed ID: 36502633   DOI: 10.1016/j.bbrc.2022.11.098

21068  Yamakado N, Okuda S, Tobiume K, Uetsuki R, Ono S, Mizuta K, Nakagawa T, Aikawa T.  Chemical inhibition of LSD1 leads to epithelial to mesenchymal transition in vitro of an oral squamous cell carcinoma OM-1 cell line via release from LSD1-dependent suppression of ZEB1.  Biochem Biophys Res Commun  2023  647:23-29  PubMed ID: 36709669   DOI: 10.1016/j.bbrc.2023.01.062

21100  Suzuki Y, Nakamoto C, Watanabe-Iida I, Watanabe M, Takeuchi T, Sasaoka T, Abe M, Sakimura K.  Quantitative analysis of NMDA receptor subunits proteins in mouse brain.  Neurochem Int  2023  105517  PubMed ID: 36913980   DOI: 10.1016/j.neuint.2023.105517

21116  Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y.  Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.  Cells  2023  12(4)  PubMed ID: 36831269   DOI: 10.3390/cells12040602

21153  Yang W, Miyazaki T, Nakagawa Y, Boonstra E, Masuda K, Nakashima Y, Chen P, Mixich L, Barthelmes K, Matsumoto A, Mi P, Uchida S, Cabral H.  Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π-π stacking-assisted micellar assembly.  Sci Technol Adv Mater  2023  24(1):2170164  PubMed ID: 36950277   DOI: 10.1080/14686996.2023.2170164

21214  Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H.  Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality.  iScience  2023  26(4):106487  PubMed ID: 37096037   DOI: 10.1016/j.isci.2023.106487

21246  Ishiyama S, Hasegawa T, Sugeno N, Kobayashi J, Yoshida S, Miki Y, Wakabayashi K, Fukuda M, Kawata Y, Nakamura T, Sato K, Ezura M, Kikuchi A, Takeda A, Aoki M.  Sortilin acts as an endocytic receptor for α-synuclein fibril.  FASEB J  2023  37(7):e23017  PubMed ID: 37272890   DOI: 10.1096/fj.202201605RR

21270  Yamaguchi S, Kamino M, Hamamura M, Otsuguro KI.  The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells.  PLoS One  2023  18(6):e0287249  PubMed ID: 37352201   DOI: 10.1371/journal.pone.0287249

21333  Kogaki T, Hase H, Tanimoto M, Tashiro A, Kitae K, Ueda Y, Jingushi K, Tsujikawa K.  ALKBH4 is a novel enzyme that promotes translation through modified uridine regulation.  J Biol Chem  2023  105093  PubMed ID: 37507018   DOI: 10.1016/j.jbc.2023.105093

21384  Nishida K, Wang G, Kobatake E, Mie M.  Sensitive Detection of Tumor Cells Using Protein Nanoparticles with Multiple Displays of DNA Aptamers and Bioluminescent Reporters.  ACS Biomater Sci Eng  2023    PubMed ID: 37642536   DOI: 10.1021/acsbiomaterials.3c00712

21453  Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.  Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.  J Pharmacol Sci  2023  153(3):153-160  PubMed ID: 37770156   DOI: 10.1016/j.jphs.2023.08.008

21467  Suzuki S, Saito S, Narushima Y, Kodani S, Kagaya N, Suenaga H, Shin-Ya K, Arai MA.  Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation.  J Antibiot (Tokyo)  2023    PubMed ID: 37938761   DOI: 10.1038/s41429-023-00673-4

21485  Zhao X, Ma D, Ishiguro K, Saito H, Akichika S, Matsuzawa I, Mito M, Irie T, Ishibashi K, Wakabayashi K, Sakaguchi Y, Yokoyama T, Mishima Y, Shirouzu M, Iwasaki S, Suzuki T, Suzuki T.  Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.  Cell  2023    PubMed ID: 37992713   DOI: 10.1016/j.cell.2023.10.026

17537  Emiko Kinoshita-Kikuta, Yoko Ino, Yayoi Kimura, Tomoko Akiyama, Eiji Kinoshita, Tohru Koike  Use of Escherichia coli expression system for analyzing kinase motifs  Journal of Electrophoresis  2022  66:13-20    DOI: 10.2198/jelectroph.66.13

17583  Han H, Akiyoshi T, Morita T, Kataoka H, Katayama K, Yajima K, Imaoka A, Ohtani H.  Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants  Drug Metab Pharmacokinet  2022  47:100470  PubMed ID: 36116173   DOI: 10.1016/j.dmpk.2022.100470

17609  Yoshihara A, Kawasaki H, Masuno H, Takada K, Numoto N, Ito N, Hirata N, Kanda Y, Ishizawa M, Makishima M, Kagechika H, Tanatani A.  Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists  Biomolecules  2022  12(1):130  PubMed ID: 35053278   DOI: 10.3390/biom12010130

17708  Nakamura Y, Kozakai H, Nishio T, Yoshida K, Nakanishi T.  Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1  Drug Metab Pharmacokinet  2022  44:100452  PubMed ID: 35299026   DOI: 10.1016/j.dmpk.2022.100452

17798  Chen P, Yang W, Hong T, Miyazaki T, Dirisala A, Kataoka K, Cabral H.  Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC  Biomaterials  2022  288:121748  PubMed ID: 36038419   DOI: 10.1016/j.biomaterials.2022.121748

15439  Shams R, Matsukawa A, Ochi Y, Ito Y, Miyatake H.  In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1  J Med Chem  2022  Jun 30  PubMed ID: 34191518   DOI: 10.1021/acs.jmedchem.1c00536

20553  Urabe T, Miyoshi H, Narasaki S, Yanase Y, Uchida K, Noguchi S, Hide M, Tsutsumi YM, Sakai N.  Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic.  PLoS One  2022  17(2):e0263395  PubMed ID: 35104283   DOI: 10.1371/journal.pone.0263395

16391  Sakamoto T, Yu Z, Otani Y.  Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells  Anal Chem  2022  Mar 2  PubMed ID: 35234461   DOI: 10.1021/acs.analchem.1c04804

20612  Yamatoya K, Nagai Y, Teramoto N, Kang W, Miyado K, Nakata K, Yagi T, Miyamoto Y.  Cryopreservation of undifferentiated and differentiated human neuronal cells.  Regen Ther  2022  19:58-68  PubMed ID: 35059480   DOI: 10.1016/j.reth.2021.12.007

20616  Liu JY, Inoshita T, Shiba-Fukushima K, Yoshida S, Ogata K, Ishihama Y, Imai Y, Hattori N.  Ubiquitination at the lysine 27 residue of the parkin ubiquitin-like domain is suggestive of a new mechanism of parkin activation.  Hum Mol Genet  2022    PubMed ID: 35313349   DOI: 10.1093/hmg/ddac064

20649  Liu Y, Nisisako T.  Microfluidic generation of monodispersed Janus alginate hydrogel microparticles using water-in-oil emulsion reactant.  Biomicrofluidics  2022  16(2):024101  PubMed ID: 35282035   DOI: 10.1063/5.0077916

20657  Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y.  Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.  Biochem Biophys Rep  2022  29:101223  PubMed ID: 35146136   DOI: 10.1016/j.bbrep.2022.101223

20701  Yonezawa H, Ikeda A, Takahashi R, Endo H, Sugawara Y, Goto M, Kanno M, Ogawa S, Nakamura K, Ujiie H, Iwatsuki M, Hirose T, Sunazuka T, Uehara Y, Nishiya N.  Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases.  iScience  2022  25(3):103912  PubMed ID: 35530256   DOI: 10.1016/j.isci.2022.103912

20774  Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.  Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.  Nat Commun  2022  13(1):4063  PubMed ID: 35831322   DOI: 10.1038/s41467-022-31690-w

20796  Honda T, Kawasaki N, Yanagihara R, Tamura R, Murakami K, Ichimiya T, Matsumoto N, Nishihara S, Yamamoto K.  Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9).  PLoS One  2022  17(7):e0268485  PubMed ID: 35901072   DOI: 10.1371/journal.pone.0268485

20807  Ertunc N, Phitak T, Wu D, Fujita H, Hane M, Sato C, Kitajima K.  Sulfation of sialic acid is ubiquitous and essential for vertebrate development.  Sci Rep  2022  12(1)  PubMed ID: 35864127   DOI: 10.1038/s41598-022-15143-4

20816  Krama A, Tokura N, Isoda H, Shigemori H, Miyamae Y.  Cyanidin 3-Glucoside Induces Hepatocyte Growth Factor in Normal Human Dermal Fibroblasts through the Activation of β2-Adrenergic Receptor.  ACS Omega  2022  7(26):22889-22895  PubMed ID: 35811916   DOI: 10.1021/acsomega.2c02659

20890  Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E.  Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.  Nat Commun  2022  13(1):6092  PubMed ID: 36241662   DOI: 10.1038/s41467-022-33842-4

20897  Ito M, Maejima Y, Nishimura K, Nakae Y, Ono A, Iwaki-Egawa S.  A role for N-glycosylation in active adenosine deaminase 2 production.  Biochim Biophys Acta Gen Subj  2022  1866(12):130237  PubMed ID: 36029899   DOI: 10.1016/j.bbagen.2022.130237

20923  Isobe A, Arai Y, Kuroda D, Okumura N, Ono T, Ushiba S, Nakakita SI, Daidoji T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y.  ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner.  Commun Biol  2022  5(1):1188  PubMed ID: 36335195   DOI: 10.1038/s42003-022-04170-6

20954  Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M.  ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.  Nat Commun  2022  13(1):7476  PubMed ID: 36463234   DOI: 10.1038/s41467-022-35230-4

21000  Miyoshi K, Shimizu S, Shiraki A, Egi M.  Ubiquitination of the μ-opioid receptor regulates receptor internalization without affecting Gi/o-mediated intracellular signaling or receptor phosphorylation.  Biochem Biophys Res Commun  2022  643:96-104  PubMed ID: 36592585   DOI: 10.1016/j.bbrc.2022.12.077

20101  Matsuo T, Isosaka T, Hayashi Y, Tang L, Doi A, Yasuda A, Hayashi M, Lee CY, Cao L, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu Q, Kobayakawa R, Kobayakawa K.  Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.  Nat Commun  2021  12(1):2074  PubMed ID: 33824316   DOI: 10.1038/s41467-021-22205-0

20182  Takahashi K, Araki K, Miyamoto H, Shirakawa R, Yoshida T, Wakamori M.  Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization.  Front Pharmacol  2021  12:672157  PubMed ID: 34093200   DOI: 10.3389/fphar.2021.672157

20187  Miki T, Nakai T, Hashimoto M, Kajiwara K, Tsutsumi H, Mihara H.  Intracellular artificial supramolecules based on de novo designed Y15 peptides.  Nat Commun  2021  12(1):3412  PubMed ID: 34099696   DOI: 10.1038/s41467-021-23794-6

20197  Ju N, Hayashi H, Shimamura M, Yoshida S, Nakamaru R, Nakagami H, Morishita R, Rakugi H.  Prevention of Acute Lung Injury by a Novel CD14-Inhibitory Receptor Activator of the NF-κB Ligand Peptide in Mice.  Immunohorizons  2021  5(6):438-447  PubMed ID: 34131020   DOI: 10.4049/immunohorizons.2000112

20217  Takashima S, Kurogochi M, Tsukimura W, Mori M, Osumi K, Sugawara SI, Amano J, Mizuno M, Takada Y, Matsuda A.  Preparation and biological activities of anti-HER2 monoclonal antibodies with multi-branched complex-type N-glycans.  Glycobiology  2021    PubMed ID: 34192331   DOI: 10.1093/glycob/cwab064

20272  Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.  Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.  Sci Rep  2021  11(1):13471  PubMed ID: 34188113   DOI: 10.1038/s41598-021-92860-2

15274  Yasuda K, Matsubara T, Shirakawa T, Kawamoto T, Kokabu S.  Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos  Bone Rep  2021  5:101114  PubMed ID: 34401407   DOI: 10.1016/j.bonr.2021.101114

15284  Yoshiko Iizuka, Kinuko Inomata, Risako Nohara, Akimitsu Miyawaki and Yoshifumi Watanabe  Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus  International Journal of Herbal Medicine  2021  9(3):54-60

20357  Watanabe Y, Sugano E, Tabata K, Hatakeyama A, Sakajiri T, Fukuda T, Ozaki T, Suzuki T, Sayama T, Tomita H.  Development of an optogenetic gene sensitive to daylight and its implications in vision restoration.  NPJ Regen Med  2021  6(1):64  PubMed ID: 34650094   DOI: 10.1038/s41536-021-00177-5

15664  Tabata K, Sugano E, Hatakeyama A, Watanabe Y, Suzuki T, Ozaki T, Fukuda T, Tomita H.  Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene  Int J Mol Sci   2021  ;22(13):6732  PubMed ID: 34201658   DOI: 10.3390/ijms22136732

20417  Shams R, Ito Y, Miyatake H.  Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays.  Int J Mol Sci  2021  22(16)  PubMed ID: 34445471   DOI: 10.3390/ijms22168766

20441  Hongprasit A, Okamoto Y, Toida T, Ogra Y.  Comparison of quantification of selenocyanate and thiocyanate in cultured mammalian cells between HPLC-fluorescence detector and HPLC-inductively coupled plasma mass spectrometer.  J Chromatogr B Analyt Technol Biomed Life Sci  2021  1181:122924  PubMed ID: 34508979   DOI: 10.1016/j.jchromb.2021.122924

15887  See K, Kadonosono T, Miyamoto K, Tsubaki T, Ota Y, Katsumi M, Ryo S, Aida K, Minegishi M, Isozaki T, Kuchimaru T, Kizaka-Kondoh S.  Antibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display  Sci Rep  2021  11(1):22098  PubMed ID: 34764369   DOI: 10.1038/s41598-021-01603-w

16832  Nakanishi T, Maekawa A, Suzuki M, Tabata H, Sato K, Mori M, Saito I.  Construction of adenovirus vectors simultaneously expressing four multiplex, double-nicking guide RNAs of CRISPR/Cas9 and in vivo genome editing  Sci Rep  2021  11(1):3961  PubMed ID: 33597562   DOI: 10.1038/s41598-021-83259-0

16860  Akaike Y, Nakane Y, Chibazakura T.  Analysis of E1A domains involved in the enhancement of CDK2 activity  Biochem Biophys Res Commun  2021  548:98-103  PubMed ID: 33640611   DOI: 10.1016/j.bbrc.2021.02.064

6934  Baba K, Kuwada S, Nakao A, Li X, Okuda N, Nishida A, Mitsuda S, Fukuoka N, Kakeya H, Kataoka T.  Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.  Histochem Cell Biol  2020    PubMed ID: 31907597   DOI: 10.1007/s00418-019-01842-z

9190  Rui Jiang, Ziyan Zhang, Zhiwei Zhong, Yuxuan Dai, Guangyao Liu, Chao Zhang  Phosphorylation of Histone H4 at Serine 1 Is Associated With GCN5 and Mediates Autophagy in Osteosarcoma Bone Cell Lines  J Cell Physiol   2020    PubMed ID: 31903552   DOI: 10.1002/jcp.29434

9738  Kanano Kitamura, Jane Surya Erlangga, Sakuka Tsukamoto, Yuri Sakamoto, Hideaki Mabashi-Asazuma, Kaoruko Iida  Daidzein Promotes the Expression of Oxidative Phosphorylation- And Fatty Acid Oxidation-Related Genes via an Estrogen-Related Receptor α Pathway to Decrease Lipid Accumulation in Muscle Cells  J Nutr Biochem  2020  77:108315  PubMed ID: 31923756   DOI: 10.1016/j.jnutbio.2019.108315

10370  Yusuke Higuchi, Jun-Ichirou Yasunaga, Yu Mitagami, Hirotake Tsukamoto, Kazutaka Nakashima, Koichi Ohshima, Masao Matsuoka  HTLV-1 Induces T Cell Malignancy and Inflammation by Viral Antisense Factor-Mediated Modulation of the Cytokine Signaling  Proc Natl Acad Sci U S A  2020  117(24):13740-13749  PubMed ID: 32471947   DOI: 10.1073/pnas.1922884117

12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870   DOI: 10.1016/j.heliyon.2020.e03301

12113  Horii T, Morita S, Hino S, Kimura M, Hino Y, Kogo H, Nakao M, Hatada I.  Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome.  Genome Biol.  2020    PubMed ID: 32234052   DOI: 10.1186/s13059-020-01991-8

12360  Morita T, Akiyoshi T, Sato R, Katayama K, Yajima K, Kataoka H, Imaoka A, Sugimoto Y, Ohtani H.  pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2  Drug Metab Pharmacokinet  2020  35(2):220-227  PubMed ID: 31974044   DOI: 10.1016/j.dmpk.2019.12.002

13037  Ueda M, Matsuki T, Fukada M, Eda S, Toya A, Iio A, Tabata H, Nakayama A.  Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.  Mol Brain  2020    PubMed ID: 32448361   DOI: 10.1186/s13041-020-00622-4

13046  Ouchi K, Miyachi M, Yagyu S, Kikuchi K, Kuwahara Y, Tsuchiya K, Iehara T, Hosoi H.  Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells.  Cancer Cell Int  2020    PubMed ID: 32489328   DOI: 10.1186/s12935-020-01282-z

13073  Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.  Free Radic Biol Med  2020    PubMed ID: 32553752   DOI: 10.1016/j.freeradbiomed.2020.06.005

13095  Mai NNH, Yamaguchi Y, Choijookhuu N, Matsumoto J, Nanashima A, Takagi H, Sato K, Tuan LQ, Hishikawa Y.  Photodynamic Therapy Using a Novel Phosphorus Tetraphenylporphyrin Induces an Anticancer Effect via Bax/Bcl-xL-related Mitochondrial Apoptosis in Biliary Cancer Cells.  Acta Histochem Cytochem  2020    PubMed ID: 32873990   DOI: 10.1267/ahc.20-00002

13115  Urabe T, Yanase Y, Motoike S, Harada K, Hide I, Tanaka S, Tsutsumi YM, Kawamoto M, Sakai N.  Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria.  Eur J Pharmacol  2020    PubMed ID: 32681942   DOI: 10.1016/j.ejphar.2020.173303

13163  Furuno K, Wang J, Suzuki K, Nakahata M, Sakai S.  Gelatin-Based Electrospun Fibers Insolubilized by Horseradish Peroxidase-Catalyzed Cross-Linking for Biomedical Applications.  ACS Omega  2020    PubMed ID: 32875262   DOI: 10.1021/acsomega.0c03164

13193  Iio A, Kaji K, Kaji N, Hori M, Yonezawa T, Momoi Y, Maeda S.  Expression analysis of protease-activated receptor-2 in cats.  Vet Immunol Immunopathol  2020    PubMed ID: 32932190   DOI: 10.1016/j.vetimm.2020.110115

13200  Ago Y, Otsuka H, Sasai H, Abdelkreem E, Nakama M, Aoyama Y, Matsumoto H, Fujiki R, Ohara O, Akiyama K, Fukui K, Watanabe Y, Nakajima Y, Ohnishi H, Ito T, Fukao T.  Japanese patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: In vitro functional analysis of five novel HMGCS2 mutations.  Exp Ther Med  2020    PubMed ID: 32952630   DOI: 10.3892/etm.2020.9166

13307  Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y.  CELF2 regulates the species-specific alternative splicing of TREM2.  Sci Rep  2020    PubMed ID: 33093587   DOI: 10.1038/s41598-020-75057-x

13349  Konishi H, Hayashi M, Taniguchi K, Nakamura M, Kuranaga Y, Ito Y, Kondo Y, Sasaki H, Terai Y, Akao Y, Ohmichi M.  The therapeutic potential of exosomal miR-22 for cervical cancer radiotherapy.  Cancer Biol Ther  2020    PubMed ID: 33190594   DOI: 10.1080/15384047.2020.1838031

13584  Uda RM, Yoshida N, Iwasaki T, Hayashi K.  pH-triggered solubility and cytotoxicity changes of malachite green derivatives incorporated in liposomes for killing cancer cells  J Mater Chem B  2020  8(36):8242-8248  PubMed ID: 32794526   DOI: 10.1039/d0tb01346c

13610  Puteri MU, Watanabe Y, Wardhani BWK, Amalia R, Abdelaziz M, Kato M.  PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells  Genes Cells  2020  25(6):375-390  PubMed ID: 32181976   DOI: 10.1111/gtc.12766

13620  Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N.  Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats  Front Pharmacol  2020  11:1277  PubMed ID: 32922296   DOI: 10.3389/fphar.2020.01277

13944  Akaike Y, Chibazakura T.  Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells  Cell Cycle  2020  19(1):84-96  PubMed ID: 31760882   DOI: 10.1080/15384101.2019.1693119

14836  Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M.  Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library  Cell Chem Biol   2020  27(6):708-718.e1  PubMed ID: 32402240   DOI: 10.1016/j.chembiol.2020.04.007

11179  Ali F, Hossain MS, Sejimo S, Akashi K.  Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells.  Mol. Neurobiol.  2019  56(5):3404-3419  PubMed ID: 30128650   DOI: 10.1007/s12035-018-1307-2

4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549   DOI: 10.1038/s41467-019-09028-w

11312  Manabe A, Furukawa C, Hasegawa H, Matsunaga T, Endo S, Ikari A.  Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.  J. Cell. Physiol.  2019    PubMed ID: 30461012   DOI: 10.1002/jcp.27565

11394  Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H.  Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging.  Cell Metab.  2019    PubMed ID: 30661929   DOI: 10.1016/j.cmet.2018.12.021

11402  Morita M, Hashimoto O.  Identification and expression of the medaka inhibin βE subunit.  Mol. Biol. Rep.  2019    PubMed ID: 30680594   DOI: 10.1007/s11033-019-04607-y

11412  Zhang W, Matsuo R, Takahara T, Shibata H, Maki M.  High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins.  Methods Mol. Biol.  2019    PubMed ID: 30710293   DOI: 10.1007/978-1-4939-9030-6_31

11411  Zhang W, Takahara T, Achiha T, Shibata H, Maki M.  Cellular Ca2+-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements.  Methods Mol. Biol.  2019    PubMed ID: 30710269   DOI: 10.1007/978-1-4939-9030-6_7

6050  Yokota S, Kuramochi H, Okubo K, Iwaya A, Tsuchiya S, Ichiki T.  Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes.  PLoS One  2019  14(10):e0224091  PubMed ID: 31648253   DOI: 10.1371/journal.pone.0224091

11580  Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, Yukimori A, Takakura I, Sumimoto H, Fukada T, Azuma M, Akiyama H, Nishimura R, Shimane T, Mishima K.  Sox9 regulates the luminal stem/progenitor cell properties of salivary glands.  Exp. Cell Res.  2019    PubMed ID: 31153924   DOI: 10.1016/j.yexcr.2019.05.030

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11628  Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.  Identification of ryuvidine as a KDM5A inhibitor.  Sci Rep  2019    PubMed ID: 31289306   DOI: 10.1038/s41598-019-46346-x

11800  Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.  Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.  Sci Rep  2019    PubMed ID: 31520002   DOI: 10.1038/s41598-019-49744-3

11867  Ginting TE, Christian S, Larasati YO, Suryatenggara J, Suriapranata IM, Mathew G.  Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis.  Sci Rep  2019    PubMed ID: 31641164   DOI: 10.1038/s41598-019-51465-6

6899  Miyano K, Shiraishi S, Minami, Sudo Y, Suzuki M, Yokoyama T, Terawaki K, Nonaka M, Murata H, Higami Y, Uezono Y.  Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways.  Int J Mol Sci  2019  20(13):3271  PubMed ID: 31277262   DOI: 10.3390/ijms20133271

6937  Ryo Muko et al  Cloning and Detection of Equine Histidine-Rich Glycoprotein  Journal of Equine Veterinary Science  2019  73:121-126    DOI: 10.1016/j.jevs.2018.12.009

9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594

10396  Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori, Shunichi Shimizu  Protective Effects of Duloxetine Against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition  J Pharmacol Exp Ther  2019  368(2):246-254  PubMed ID: 30523061   DOI: 10.1124/jpet.118.253922

10397  Murat Kutluay, Makoto Inoue and Iclal Saracoglu  Assessment of LXRα agonist activity and selective antiproliferative efficacy: a study on different parts of Digitalis species  Turkish Journal of Biochemistry  2019  44    DOI: 10.1515/tjb-2018-0280

10400  Shun Adachi  Induction of hierarchy and time through one-dimensional probability space with certain topologies  bioRxiv  2019  September 24    DOI: 10.1101/780882

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12361  Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.  Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy  J Neurochem  2019  148(3):373-385  PubMed ID: 30295925   DOI: 10.1111/jnc.14607

7018  Uchida S, Yoshinaga N, Yanagihara K, Yuba E, Kataoka K, Itaka K.  Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination.  Biomaterials  2018  150:162-170  PubMed ID: 29031816   DOI: 10.1016/j.biomaterials.2017.09.033

18201  Daizumoto K, Yoshimaru T, Matsushita Y, Fukawa T, Uehara H, Ono M, Komatsu M, Kanayama HO, Katagiri T.  A DDX31/Mutant-p53/EGFR Axis Promotes Multistep Progression of Muscle-Invasive Bladder Cancer  Cancer Res  2018  78(9):2233-2247.  PubMed ID: 29440146   DOI: 10.1158/0008-5472.CAN-17-2528

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11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296   DOI: 10.1021/acs.bioconjchem.8b00250

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11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880   DOI: 10.2116/analsci.17P462

11260  Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.  Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.  Mol. Pharm.  2018    PubMed ID: 30359033   DOI: 10.1021/acs.molpharmaceut.8b00921

11268  Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.  Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.  Cell Rep  2018    PubMed ID: 30380411   DOI: 10.1016/j.celrep.2018.10.008

11399  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Yuyama K, Nakamura H, Fu Q, Maehara O, Suda G, Sakamoto N.  Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.  Stem Cells Int  2018    PubMed ID: 30675167   DOI: 10.1155/2018/3212643

4085  Agata Okonska et al  Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy  bioRxiv  2018  July 31    DOI: 10.1101/381533

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4102  Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H.  Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.  PLoS ONE  2018    PubMed ID: 30500824   DOI: 10.1371/journal.pone.0203978

4103  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N.  Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.  Front Pharmacol  2018    PubMed ID: 30057547   DOI: 10.3389/fphar.2018.00709

4104  Mizuno H, Taketomi A.  MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro.  BMC Res Notes  2018    PubMed ID: 30064488   DOI: 10.1186/s13104-018-3654-5

4105  Takayama-Ito M, Lim CK, Yamaguchi Y, Posadas-Herrera G, Kato H, Iizuka I, Islam MT, Morimoto K, Saijo M.  Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge.  PLoS Negl Trop Dis  2018    PubMed ID: 29659579   DOI: 10.1371/journal.pntd.0006398

4106  Saifullah, Tsukahara T.  Genotyping of single nucleotide polymorphisms using the SNP-RFLP method.  Biosci Trends  2018    PubMed ID: 30012914   DOI: 10.5582/bst.2018.01102

4107  Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.  Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.  Int J Mol Sci  2018    PubMed ID: 30021999   DOI: 10.3390/ijms19072090

4108  Matsuura M, Ohshima M, Hiruta Y, Nishimura T, Nagase K, Kanazawa H.  LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging.  Int J Mol Sci  2018    PubMed ID: 29865203   DOI: 10.3390/ijms19061646

14542  Matsubara T, Kokabu S, Nakatomi C, Kinbara M, Maeda T, Yoshizawa M, Yasuda H, Takano-Yamamoto T, Baron R, Jimi E.  The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts  Mol Cell Biol  2018  38(4):e00425-17  PubMed ID: 29158294   DOI: 10.1128/MCB.00425-17

14701  Otero R, Ishizawa M, Numoto N, Ikura T, Ito N, Tokiwa H, Mouriño A, Makishima M, Yamada S.  25 S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D 3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex  J Med Chem  2018  61(15):6658-6673  PubMed ID: 29989817   DOI: 10.1021/acs.jmedchem.8b00427

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10079  Satou K, Mochimaru Y, Nakakura T, Kusada T, Negishi J, Musha S, Yoshimura N, Kato Y, Tomura H.  Easy detection of hormone secretion from LβT2 cells by using Gaussia luciferase.  J. Reprod. Dev.  2017  63:199-204  PubMed ID: 28090002   DOI: 10.1262/jrd.2016-174

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10416  Kubota Y, Fujioka K, Takekawa M.  WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins.  PLoS ONE  2017  12:e0180714  PubMed ID: 28686627   DOI: 10.1371/journal.pone.0180714

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10524  Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y.  L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.  JCI Insight  2017  2:  PubMed ID: 28931752   DOI: 10.1172/jci.insight.90903

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12311  Sourov Chandra 1, Grégory Beaune, Naoto Shirahata, Françoise M Winnik  A one-pot synthesis of water soluble highly fluorescent silica nanoparticles  J Mater Chem B  2017  5(7):1363-1370  PubMed ID: 32264628   DOI: 10.1039/c6tb02813f

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14485  Orimoto A, Kurokawa M, Handa K, Ishikawa M, Nishida E, Aino M, Mitani A, Ogawa M, Tsuji T, Saito M.  F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-β activity  Arch Oral Biol  2017  79:7-1  PubMed ID: 28282516   DOI: 10.1016/j.archoralbio.2017.02.019

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7056  Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M.  Forward-genetics analysis of sleep in randomly mutagenized mice.  Nature  2016  539:378-383  PubMed ID: 27806374   DOI: 10.1038/nature20142

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7127  Mimura Y, Kelly RM, Unwin L, Albrecht S, Jefferis R, Goodall M, Mizukami Y, Mimura-Kimura Y, Matsumoto T, Ueoka H, Rudd PM.  Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.  J. Immunol. Methods  2016  428:30-6  PubMed ID: 26627984   DOI: 10.1016/j.jim.2015.11.009

7150  Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, Matsuzawa A, Yoshinari K.  PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.  Biochem. J.  2016  473:257-66  PubMed ID: 26574435   DOI: 10.1042/BJ20150734

9703  Toda T, Yamamoto S, Yonezawa R, Mori Y, Shimizu S.  Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.  Eur. J. Pharmacol.  2016  786:19-28  PubMed ID: 27238971   DOI: 10.1016/j.ejphar.2016.05.033

9708  Tohno M, Shinkai H, Toki D, Okumura N, Tajima K, Uenishi H.  Identification of the Q969R gain-of-function polymorphism in the gene encoding porcine NLRP3 and its distribution in pigs of Asian and European origin.  Immunogenetics  2016  68:693-701  PubMed ID: 27236661   DOI: 10.1007/s00251-016-0917-y

9882  Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Sci Rep  2016  6:35930  PubMed ID: 27775020   DOI: 10.1038/srep35930

8922  Kashima H, Momose F, Umehara H, Miyoshi N, Ogo N, Muraoka D, Shiku H, Harada N, Asai A.  Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity.  PLoS One  2016  11(6):e0156643  PubMed ID: 27284967   DOI: 10.1371/journal.pone.0156643

12872  Niikura K, Horisawa K, Doi N.  Endosomal escape efficiency of fusogenic B18 and B55 peptides fused with anti-EGFR single chain Fv as estimated by nuclear translocation  J Biochem   2016  159(1):123-32.  PubMed ID: 26338729   DOI: 10.1093/jb/mvv083

12935  Taura A, Taura K, Koyama Y, Yamamoto N, Nakagawa T, Ito J, Ryan AF.  Hair cell stereociliary bundle regeneration by espin gene transduction after aminoglycoside damage and hair cell induction by Notch inhibition  Gene Ther  2016  23(5):415-23  PubMed ID: 26886463   DOI: 10.1038/gt.2016.12

13421  Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T.  Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress  Int J Mol Med  2016  37(6):1611-8  PubMed ID: 27082251   DOI: 10.3892/ijmm.2016.2566

13472  Kaneko Y, Daitoku H, Komeno C, Fukamizu A.  CTF18 interacts with replication protein A in response to replication stress  Mol Med Rep  2016  14(1):367-72  PubMed ID: 27175616   DOI: 10.3892/mmr.2016.5262

14027  Verdugo M, Ogra Y, Quiroz W.  Mechanisms underlying the toxic effects of antimony species in human embryonic kidney cells (HEK-293) and their comparison with arsenic species  J Toxicol Sci  2016  41(6):783-792  PubMed ID: 27853107   DOI: 10.2131/jts.41.783

14135  Medina J, Nakagawa Y, Nagasawa M, Fernandez A, Sakaguchi K, Kitaguchi T, Kojima I.  Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose  J Biol Chem   2016  291(44):23126-23135  PubMed ID: 27613866   DOI: 10.1074/jbc.M116.729863

14203  Yamada H, Tsutsumi K, Nakazawa Y, Shibagaki Y, Hattori S, Ohta Y.  Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10  PLoS One  2016  11(1):e0146593  PubMed ID: 26751795   DOI: 10.1371/journal.pone.0146593

7128  Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.  Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.  J Pharm Pharm Sci  2015  18:316-27  PubMed ID: 26626238   DOI: 10.18433/j3vk5g

7210  Shimizu S, Yonezawa R, Negoro T, Yamamoto S, Numata T, Ishii M, Mori Y, Toda T.  Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.  Int. J. Biochem. Cell Biol.  2015  68:119-27  PubMed ID: 26386353   DOI: 10.1016/j.biocel.2015.09.005

7239  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J.  Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.  Biochim. Biophys. Acta  2015  1850:2159-67  PubMed ID: 26299247   DOI: 10.1016/j.bbagen.2015.08.011

7244  Ishii T, Sato K, Kakumoto T, Miura S, Touhara K, Takeuchi S, Nakata T.  Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.  Nat Commun  2015  6:8021  PubMed ID: 26282514   DOI: 10.1038/ncomms9021

7289  Miura R, Kooriyama T, Yoneda M, Takenaka A, Doki M, Goto Y, Sanjoba C, Endo Y, Fujiyuki T, Sugai A, Tsukiyama-Kohara K, Matsumoto Y, Sato H, Kai C.  Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.  PLoS Negl Trop Dis  2015  9:e0003914  PubMed ID: 26162094   DOI: 10.1371/journal.pntd.0003914

7316  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.  Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.  Nat Commun  2015  6:7360  PubMed ID: 26059659   DOI: 10.1038/ncomms8360

7319  Kato T, Yui M, Deo VK, Park EY.  Development of Rous sarcoma Virus-like Particles Displaying hCC49 scFv for Specific Targeted Drug Delivery to Human Colon Carcinoma Cells.  Pharm. Res.  2015  32:3699-707  PubMed ID: 26047779   DOI: 10.1007/s11095-015-1730-2

7338  Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C.  MEK5 suppresses osteoblastic differentiation.  Biochem. Biophys. Res. Commun.  2015  463:241-7  PubMed ID: 25998381   DOI: 10.1016/j.bbrc.2015.05.035

7426  Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.  Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.  J. Cell. Physiol.  2015  230:2510-21  PubMed ID: 25802132   DOI: 10.1002/jcp.24988

7438  Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M.  DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification.  J. Biosci. Bioeng.  2015  120:463-6  PubMed ID: 25772439   DOI: 10.1016/j.jbiosc.2015.02.009

7489  Kamada Y, Kusakabe T, Sugimoto Y.  Amyloidogenic lysozymes accumulate in the endoplasmic reticulum accompanied by the augmentation of ER stress signals.  Biochim. Biophys. Acta  2015  1850:1107-19  PubMed ID: 25659958   DOI: 10.1016/j.bbagen.2015.01.018

7567  Tamura M, Kunihiro S, Hamashima Y, Yoshioka Y, Tone S, Kameda K.  An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells.  Biotechnology Reports  2015  6:45-50  PubMed ID: 28626696   DOI: 10.1016/j.btre.2015.02.003

9407  Michiko Yoshida, Kenji Hata, Rikako Takashima, Koichiro Ono, Eriko Nakamura, Yoshifumi Takahata, Tomohiko Murakami, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda  The Transcription Factor Foxc1 Is Necessary for Ihh-Gli2-regulated Endochondral Ossification  Nat Commun  2015  6:6653  PubMed ID: 25808752   DOI: 10.1038/ncomms7653

9473  Koichi Fujikawa, Ryo Fukumori, Saki Nakamura, Takaya Kutsukake, Takeshi Takarada, Yukio Yoneda  Potential Interactions of Calcium-Sensitive Reagents With Zinc Ion in Different Cultured Cells  PLoS One  2015  10(5):e0127421  PubMed ID: 26010609   DOI: 10.1371/journal.pone.0127421

14963  Togami K, Miyao A, Miyakoshi K, Kanehira Y, Tada H, Chono S.  Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.  Biol Pharm Bull  2015  38(2):270-6  PubMed ID: 25747986   DOI: 10.1248/bpb.b14-00659

15040  Endo Y, Noguchi S, Hara Y, Hayashi YK, Motomura K, Miyatake S, Murakami N, Tanaka S, Yamashita S, Kizu R, Bamba M, Goto Y, Matsumoto N, Nonaka I, Nishino I.  Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca²⁺ channels  Hum Mol Genet  2015  24(3):637-48  PubMed ID: 25227914   DOI: 10.1093/hmg/ddu477

10473  Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.  The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy  PLoS One  2015  10(7):e0133713  PubMed ID: 26226340   DOI: 10.1371/journal.pone.0133713

15221  Sasaki A, Yamamoto J, Jin T, Kinjo M.  Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs  Sci Rep  2015  5:14428  PubMed ID: 26400011   DOI: 10.1038/srep14428

15228  Narita K, Sasamoto S, Koizumi S, Okazaki S, Nakamura H, Inoue T, Takeda S.  TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport  FASEB J  2015  29(6):2247-59  PubMed ID: 25681460   DOI: 10.1096/fj.14-261396

15441  Tamura M, Kawano M, Sato M, Nashimoto M.  Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing  Mol Med Rep  2015  12(4):6365  PubMed ID: 26238202   DOI: 10.3892/mmr.2015.4160

12955  Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mouriño, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada  Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds  Journal of Medicinal Chemistry  2015  58:9510-9521  PubMed ID: 26613420   DOI: 10.1021/acs.jmedchem.5b00792

5614  Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, Sakamoto N.  Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats  Cell Transplant  2015  24(12):2601-14  PubMed ID: 25812083   DOI: 10.3727/096368915X687570

17445  Nakayama T, Saitoh H.  Tunicamycin-induced neutrophil extracellular trap (NET)-like structures in cultured human myeloid cell lines  Cell Biol Int  2015  39(3):355-9.  PubMed ID: 25336229   DOI: 10.1002/cbin.10396

17456  Hosoda F, Arai Y, Okada N, Shimizu H, Miyamoto M, Kitagawa N, Katai H, Taniguchi H, Yanagihara K, Imoto I, Inazawa J, Ohki M, Shibata T.  Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer  Oncogene  2015  34(9):1196-206  PubMed ID: 24662817   DOI: 10.1038/onc.2014.57

6236  Xu H, Shen Z, Xiao J, Yang Y, Huang W, Zhou Z, Shen J, Zhu Y1, Liu XY, Chu L.  Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect.  BMC Cancer  2014  14:668  PubMed ID: 25220382   DOI: 10.1186/1471-2407-14-668

3443  Shimizu S, Yonezawa R, Hagiwara T, Yoshida T, Takahashi N, Hamano S, Negoro T, Toda T, Wakamori M, Mori Y, Ishii M.  Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry.  Eur J Pharmacol  2014  742:22-30  PubMed ID: 25179574   DOI: 10.1016/j.ejphar.2014.08.023

9113  Mutsuyo Takayama-Ito, Kazuo Nakamichi, Hitomi Kinoshita, Satsuki Kakiuchi, Ichiro Kurane, Masayuki Saijo, Chang-Kweng Lim  A Sensitive in Vitro Assay for the Detection of Residual Viable Rabies Virus in Inactivated Rabies Vaccines  Biologicals  2014  42 (1), 42-7  PubMed ID: 24321529   DOI: 10.1016/j.biologicals.2013.11.003

9475  Kazuhiro Shiozaki, Sena Ryuzono, Naoto Matsushita, Asami Ikeda, Kazuki Takeshita, Petros Kingstone Chigwechokha, Masaharu Komatsu, Taeko Miyagi  Molecular Cloning and Biochemical Characterization of Medaka (Oryzias Latipes) Lysosomal neu4 Sialidase  Fish Physiol Biochemc  2014  40(5):1461-72  PubMed ID: 24744226   DOI: 10.1007/s10695-014-9940-9

9478  Petros Kingstone Chigwechokha, Masaharu Komatsu, Takao Itakura, Kazuhiro Shiozaki  Nile Tilapia Neu3 Sialidases: Molecular Cloning, Functional Characterization and Expression in Oreochromis Niloticus  Gene  2014  552(1):155-64  PubMed ID: 25234733   DOI: 10.1016/j.gene.2014.09.029

15322  Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H.  Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene  J Nat Prod  2014  77(7):1670-7  PubMed ID: 24959987   DOI: 10.1021/np5002016

15820  Takeuchi T, Kubo Y, Okano K, Okano T.  Identification and characterization of cryptochrome4 in the ovary of western clawed frog Xenopus tropicalis  Zoolog Sci  2014  31(3):152-9  PubMed ID: 24601777   DOI: 10.2108/zsj.31.152

15910  Wang H, Cai Z, Yang F, Luo J, Satoh M, Arai Y, Li D.  Enhanced antitumor efficacy of integrin-targeted oncolytic adenovirus AxdAdB3-F/RGD on bladder cancer  Urology  2014  83(2):508.e13-9  PubMed ID: 24315309   DOI: 10.1016/j.urology.2013.10.025

15911  Tan C, Takayama T, Takaoka N, Fujita H, Miyazaki M, Sugiyama T, Ozono S.  Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival  Clin Med Insights Oncol  2014  8:21-7  PubMed ID: 24653654   DOI: 10.4137/CMO.S13684

16007  Zhou B, Wei FY, Kanai N, Fujimura A, Kaitsuka T, Tomizawa K.  Identification of a splicing variant that regulates type 2 diabetes risk factor CDKAL1 level by a coding-independent mechanism in human.  Hum Mol Genet  2014  23(17):4639-50  PubMed ID: 24760768   DOI: 10.1093/hmg/ddu184

18281  Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K.  Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a)  Biochem Biophys Res Commun  2013  441(1):157-63  PubMed ID: 24134843   DOI: 10.1016/j.bbrc.2013.10.020

4392  Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T.  Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes).  Biochimie  2013  95(2):280-9  PubMed ID: 23032629   DOI: 10.1016/j.biochi.2012.09.026

6565  Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H.  β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor.  Arthritis Rheum  2013  65(2):429-35  PubMed ID: 23124878   DOI: 10.1002/art.37779

9099  Syed Ahmed, Jinhua Dong, Megumi Yui, Tatsuya Kato, Jaebeom Lee, Enoch Y Park  Quantum Dots Incorporated Magnetic Nanoparticles for Imaging Colon Carcinoma Cells  J Nanobiotechnology  2013  11, 28  PubMed ID: 23957878   DOI: 10.1186/1477-3155-11-28

12710  Ohnishi S, Maehara O, Nakagawa K, Kameya A, Otaki K, Fujita H, Higashi R, Takagi K, Asaka M, Sakamoto N, Kobayashi M, Takeda H.  hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors  PLoS One  2013  8(6):e66255  PubMed ID: 23840432   DOI: 10.1371/journal.pone.0066255

15769  Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, Martelli AM, Topham MK, Iino M, Goto K.  Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity  J Cell Sci  2013  126(Pt 13):2785-97  PubMed ID: 23606744   DOI: 10.1242/jcs.118711

15922  Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.  Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers  Proc Natl Acad Sci U S A   2013  110(6):2105-10  PubMed ID: 23345451   DOI: 10.1073/pnas.1214233110

15927  Togo Y, Takahashi K, Saito K, Kiso H, Huang B, Tsukamoto H, Hyon SH, Bessho K.  Aldehyded Dextran and ε -Poly(L-lysine) Hydrogel as Nonviral Gene Carrier  Stem Cells Int  2013  2013:634379  PubMed ID: 24027586   DOI: 10.1155/2013/634379

15928  Tanaka YT, Tanaka K, Kojima H, Hamada T, Masutani T, Tsuboi M, Akao Y.  Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B  Bioorg Med Chem Lett  2013  23(2):518-23  PubMed ID: 23232059   DOI: 10.1016/j.bmcl.2012.11.034

15933  Koyama T, Sun B, Tokunaga K, Tatsumi M, Ishizaka Y.  DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition  Retrovirology  2013  10:21  PubMed ID: 23432899   DOI: 10.1186/1742-4690-10-21

15956  Nishimoto T, Kashiwagi K, Saito N, Shirai Y.  Both C1B domain and pseudosubstrate region are necessary for saturated fatty acid-induced translocation of εPKC to the plasma membrane: distinct role of intramolecular domains for different translocation  Biochem Biophys Res Commun  2013  432(2):384-8  PubMed ID: 23353652   DOI: 10.1016/j.bbrc.2013.01.048

15960  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner  Biochem J  2013  450(2):303-9  PubMed ID: 23256752   DOI: 10.1042/BJ20121348

6313  Shen J, Maruyama IN.  Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells.  J Mol Signal  2012  7(1):2  PubMed ID: 22269274   DOI: 10.1186/1750-2187-7-2

6421  Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T.  Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.  J Biol Chem  2012  287(40):33179-90  PubMed ID: 22869368   DOI: 10.1074/jbc.M111.337063

10965  Makoto Ayaori, Emi Yakushiji, Masatsune Ogura, Kazuhiro Nakaya, Tetsuya Hisada, Harumi Uto-Kondo, Shunichi Takiguchi, Yoshio Terao, Makoto Sasaki, Tomohiro Komatsu, Maki Iizuka, Makiko Yogo, Yoshinari Uehara, Hiroyuki Kagechika, Tsuyoshi Nakanishi, Katsunori Ikewaki  Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages  Biochim Biophys Acta  2012  1821(4):561-72  PubMed ID: 22353356   DOI: 10.1016/j.bbalip.2012.02.004

12260  Ryo Fukumori, Takeshi Takarada, Yuki Kambe, Ryota Nakazato, Koichi Fujikawa, Yukio Yoneda  Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-D-aspartate receptor channels  Neurochem Int  2012  61(4):498-505  PubMed ID: 22490607   DOI: 10.1016/j.neuint.2012.03.019

12733  Kotani H, Tanabe H, Mizukami H, Amagaya S, Inoue M.  A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers  Biol Pharm Bull  2012  35(1):1-9  PubMed ID: 22223330   DOI: 10.1248/bpb.35.1

15344  Kakutani R, Adachi Y, Takata H, Kuriki T, Ohno N.  Essential role of Toll-like receptor 2 in macrophage activation by glycogen  Glycobiology  2012  22(1):146-59  PubMed ID: 21873606   DOI: 10.1093/glycob/cwr122

15738  Kawai S, Amano A.  BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex  J Cell Biol  2012  197(2):201-8  PubMed ID: 22492723   DOI: 10.1083/jcb.201110008

16593  Takahashi M, Elbarbary RA, Abe M, Sato M, Yoshida T, Yamada Y, Tamura M, Nashimoto M.  Elimination of specific miRNAs by naked 14-nt sgRNAs  PLoS One  2012  7(6):e38496  PubMed ID: 22675569   DOI: 10.1371/journal.pone.0038496

7658  Gono T, Takarada T, Fukumori R, Kawaguchi Y, Kaneko H, Hanaoka M, Katsumata Y, Yoneda Y, Yamanaka H.  NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus.  Arthritis Rheum.  2011  63:3952-9  PubMed ID: 22012858   DOI: 10.1002/art.30616

7704  Ozasa H, Ayaori M, Iizuka M, Terao Y, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Uehara Y, Ogura M, Sasaki M, Komatsu T, Horii S, Mochizuki S, Yoshimura M, Ikewaki K.  Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: findings from in vitro and ex vivo studies.  Atherosclerosis  2011  219:141-50  PubMed ID: 21862012   DOI: 10.1016/j.atherosclerosis.2011.07.113

7731  Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M.  Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.  J Control Release  2011  156:195-202  PubMed ID: 21802461   DOI: 10.1016/j.jconrel.2011.07.021

7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973   DOI: 10.1016/j.febslet.2011.04.056

7833  Watanabe M, Itoh K.  Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1.  Biochim. Biophys. Acta  2011  1814:900-7  PubMed ID: 21545853   DOI: 10.1016/j.bbapap.2011.04.006

7891  Okano I, Miyazato M, Kangawa K.  A guanosine 3',5'-cyclic monophosphate (cGMP) reporter system based on the G-kinase/CREB/CRE signal transduction pathway.  Biochem. Biophys. Res. Commun.  2011  407:236-41  PubMed ID: 21382339   DOI: 10.1016/j.bbrc.2011.03.009

7912  Amano K, Hata K, Muramatsu S, Wakabayashi M, Takigawa Y, Ono K, Nakanishi M, Takashima R, Kogo M, Matsuda A, Nishimura R, Yoneda T.  Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription.  Mol. Biol. Cell  2011  22:1300-11  PubMed ID: 21346191   DOI: 10.1091/mbc.E10-07-0566

8001  Ohtani M, Miyadai T.  Functional analysis of fish BCL-6 and Blimp-1 in vitro: transcriptional repressors for B-cell terminal differentiation in fugu (Takifugu rubripes).  Mol. Immunol.  2011  48:818-25  PubMed ID: 21216469   DOI: 10.1016/j.molimm.2010.10.018

8020  Shen J, Maruyama IN.  Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.  FEBS Lett.  2011  585:295-9  PubMed ID: 21187090   DOI: 10.1016/j.febslet.2010.12.031

8047  Kohno M, Horibe T, Haramoto M, Yano Y, Ohara K, Nakajima O, Matsuzaki K, Kawakami K.  A novel hybrid peptide targeting EGFR-expressing cancers.  Eur. J. Cancer  2011  47:773-83  PubMed ID: 21112771   DOI: 10.1016/j.ejca.2010.10.021

8084  Nakura A, Higuchi C, Yoshida K, Yoshikawa H.  PKCα suppresses osteoblastic differentiation.  Bone  2011  48:476-84  PubMed ID: 20951242   DOI: 10.1016/j.bone.2010.09.238

3516  Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S.  Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines.  BMC Mol Biol  2011  12:31  PubMed ID: 21771320   DOI: 10.1186/1471-2199-12-31

15351  Terao Y, Ayaori M, Ogura M, Yakushiji E, Uto-Kondo H, Hisada T, Ozasa H, Takiguchi S, Nakaya K, Sasaki M, Komatsu T, Iizuka M, Horii S, Mochizuki S, Yoshimura M, Ikewaki K.  Effect of sulfonylurea agents on reverse cholesterol transport in vitro and vivo  J Atheroscler Thromb  2011  18(6):513-30  PubMed ID: 21636950   DOI: 10.5551/jat.7641

16164  Masateru Maruyama, Hiroki Odagiri, Shojiro-Kazunori Ikenaga, Tatsuya Nodagashira, Toshiyuki Sato, Kenichi Hakamada, Hirofumi Munakata  The suicide gene introduction using two recombinant adenovirus vectors with HER2 promoter and Cre/loxP system  Hirosaki Medical Journal  2011  61:150-158    DOI: 10.32216/hirosakiigaku.61.2-4_150

16167  Saito M, Kurokawa M, Oda M, Oshima M, Tsutsui K, Kosaka K, Nakao K, Ogawa M, Manabe RI, Suda N, Ganjargal G, Hada Y, Noguchi T, Teranaka T, Sekiguchi K, Yoneda T, Tsuji T.  ADAMTSL6β protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly  J Biol Chem  2011  286(44):38602-38613  PubMed ID: 21880733   DOI: 10.1074/jbc.M111.243451

8059  Sugimoto M, Sasaki S, Watanabe T, Nishimura S, Ideta A, Yamazaki M, Matsuda K, Yuzaki M, Sakimura K, Aoyagi Y, Sugimoto Y.  Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate.  PLoS ONE  2010  5:e13817  PubMed ID: 21072200   DOI: 10.1371/journal.pone.0013817

8070  Hashimoto O, Yonezawa T, Sugiyama Y, Kawaminami M, Hasegawa Y.  Molecular cloning and expression of canine prolactin gene.  Exp. Anim.  2010  59:643-6  PubMed ID: 21030793   DOI: 10.1538/expanim.59.643

8100  Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T.  Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.  PLoS ONE  2010  5:  PubMed ID: 20927330   DOI: 10.1371/journal.pone.0013090

8126  Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K, Nakamura H, Hirasawa N, Wada H.  Salicylate restores transport function and anion exchanger activity of missense pendrin mutations.  Hear. Res.  2010  270:110-8  PubMed ID: 20826203   DOI: 10.1016/j.heares.2010.08.015

8133  Fukumori R, Takarada T, Nakamichi N, Kambe Y, Kawagoe H, Nakazato R, Yoneda Y.  Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria.  Neurochem. Int.  2010  57:730-7  PubMed ID: 20813147   DOI: 10.1016/j.neuint.2010.08.009

8160  Kotani H, Tanabe H, Mizukami H, Makishima M, Inoue M.  Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.  J. Nat. Prod.  2010  73:1332-6  PubMed ID: 20695472   DOI: 10.1021/np100120c

8244  Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M.  Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.  Bioconjug. Chem.  2010  21:1087-95  PubMed ID: 20499901   DOI: 10.1021/bc1000609

8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766   DOI: 10.1248/bpb.33.854

8323  Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N.  Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis.  Biochem. Biophys. Res. Commun.  2010  394:153-7  PubMed ID: 20193664   DOI: 10.1016/j.bbrc.2010.02.133

8447  Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M.  Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.  J. Cell. Physiol.  2010  222:481-7  PubMed ID: 19937979   DOI: 10.1002/jcp.21988

9483  Kazunori Yamaguchi, Koichi Koseki, Momo Shiozaki, Yukiko Shimada, Tadashi Wada, Taeko Miyagi  Regulation of Plasma-Membrane-Associated Sialidase NEU3 Gene by Sp1/Sp3 Transcription Factors  Biochem J   2010  430(1):107-17  PubMed ID: 20518744   DOI: 10.1042/BJ20100350

10921  Yoko Kubo, Takahiro Takeuchi, Keiko Okano, Toshiyuki Okano  Cryptochrome Genes Are Highly Expressed in the Ovary of the African Clawed Frog, Xenopus Tropicalis  PLoS One  2010  5(2):e9273  PubMed ID: 20174658   DOI: 10.1371/journal.pone.0009273

15366  Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T.  Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway  Mol Immunol   2010  47(6):1283-91  PubMed ID: 20047764   DOI: 10.1016/j.molimm.2009.12.002

15692  Yoshikawa F, Banno Y, Otani Y, Yamaguchi Y, Nagakura-Takagi Y, Morita N, Sato Y, Saruta C, Nishibe H, Sadakata T, Shinoda Y, Hayashi K, Mishima Y, Baba H, Furuichi T.  Phospholipase D family member 4, a transmembrane glycoprotein with no phospholipase D activity, expression in spleen and early postnatal microglia  PLoS One  2010  5(11):e13932  PubMed ID: 21085684   DOI: 10.1371/journal.pone.0013932

8487  Ishii M, Kobayashi S, Ohkura M, Yamamoto R, Shimizu S, Kiuchi Y.  Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.  J. Pharmacol. Sci.  2009  111:221-5  PubMed ID: 19783864   DOI: 10.1254/jphs.09205sc

8536  Munekata K, Sakamoto K.  Forkhead transcription factor Foxo1 is essential for adipocyte differentiation.  In Vitro Cell. Dev. Biol. Anim.  2009  45:642-51  PubMed ID: 19585174   DOI: 10.1007/s11626-009-9230-5

8571  Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T.  A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.  Clin. Cancer Res.  2009  15:3725-32  PubMed ID: 19458054   DOI: 10.1158/1078-0432.CCR-08-2396

8573  Takarada T, Takahata Y, Iemata M, Hinoi E, Uno K, Hirai T, Yamamoto T, Yoneda Y.  Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.  J. Cell. Physiol.  2009  220:756-64  PubMed ID: 19452450   DOI: 10.1002/jcp.21821

8574  Takarada T, Hojo H, Iemata M, Sahara K, Kodama A, Nakamura N, Hinoi E, Yoneda Y.  Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members.  Bone  2009  45:568-78  PubMed ID: 19446054   DOI: 10.1016/j.bone.2009.05.004

8614  Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y.  Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.  Toxicol. Appl. Pharmacol.  2009  237:232-6  PubMed ID: 19341753   DOI: 10.1016/j.taap.2009.03.014

8616  Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M.  Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.  Biol. Pharm. Bull.  2009  32:564-72  PubMed ID: 19336885   DOI: 10.1248/bpb.32.564

8631  Uehara Y, Mochizuki M, Matsuno K, Haino T, Asai A.  Novel high-throughput screening system for identifying STAT3-SH2 antagonists.  Biochem. Biophys. Res. Commun.  2009  380:627-31  PubMed ID: 19285012   DOI: 10.1016/j.bbrc.2009.01.137

8690  Okamura H, Amorim BR, Wang J, Yoshida K, Haneji T.  Calcineurin regulates phosphorylation status of transcription factor osterix.  Biochem. Biophys. Res. Commun.  2009  379:440-4  PubMed ID: 19114031   DOI: 10.1016/j.bbrc.2008.12.094

18453  Yokoi H, Mizukami H, Nagatsu A, Ohno T, Tanabe H, Inoue M.  Peroxisome proliferator-activated receptor gamma ligands isolated from adlay seed (Coix lacryma-jobi L. var. ma-yuen STAPF.)  Biol Pharm Bull  2009  32(4):735-40.  PubMed ID: 19336916   DOI: 10.1248/bpb.32.735

18305  Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, Saito N.  Enzymological analysis of mutant protein kinase Cgamma causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis   J Biol Chem  2008  283(28):19854-63  PubMed ID: 18499672   DOI: 10.1074/jbc.M801492200

4714  Sakurai M, Misawa T, Shiba H, Iida T, Ohashi T, Yanaga K.  A novel approach for gene transduction with adenovirus vector and the fibrin glue system.  Anticancer Res  2008  28(6A):3809-13  PubMed ID: 19189668

3438  Kira Y1, Nishikawa M.  The identification and characterization of a new GTP-binding protein (Gbp45) involved in cell proliferation and death related to mitochondrial function.  Cell Mol Biol Lett  2008  13(4):570-84  PubMed ID: 18536999   DOI: 10.2478/s11658-008-0023-8

6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406   DOI: 10.1172/JCI31373

13805    JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts  J Bone Miner Res  2008  23(6):907-14  PubMed ID: 18251700   DOI: 10.1359/jbmr.080211

15536  Nakao N, Ono H, Yamamura T, Anraku T, Takagi T, Higashi K, Yasuo S, Katou Y, Kageyama S, Uno Y, Kasukawa T, Iigo M, Sharp PJ, Iwasawa A, Suzuki Y, Sugano S, Niimi T, Mizutani M, Namikawa T, Ebihara S, Ueda HR, Yoshimura T.  Thyrotrophin in the pars tuberalis triggers photoperiodic response  Nature   2008  452(7185):317-22  PubMed ID: 18354476   DOI: 10.1038/nature06738

16656  Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, Suematsu M, Sawai T, Morimoto C, Tanaka H.  Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1  Mol Endocrinol  2008  22(12):2609-23  PubMed ID: 18801933   DOI: 10.1210/me.2008-0101

5983  Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T.  Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23).  Genes Chromosomes Cancer  2007  46(9):813-9  PubMed ID: 17551948   DOI: 10.1002/gcc.20467

7399  Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S, Yamaguchi A.  CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways.  Biochem Biophys Res Commun  2007  354(2):567-73  PubMed ID: 17250806   DOI: 10.1016/j.bbrc.2007.01.029

12294  Shinichiro Koide, Masahiro Okazaki, Masahito Tamura, Kiyoshi Ozumi, Hiroyuki Takatsu, Fumihiko Kamezaki, Akihide Tanimoto, Hiromi Tasaki, Yasuyuki Sasaguri, Yasuhide Nakashima, Yutaka Otsuji  PTEN reduces cuff-induced neointima formation and proinflammatory cytokines  Am J Physiol Heart Circ Physiol  2007  292(6):H2824-31  PubMed ID: 17277022   DOI: 10.1152/ajpheart.01221.2006

3431  Sugihara, Eiji, Kanai, Masayuki, Saito, Soichiro, Nitta, Takayuki, Toyoshima, Hideo, Nakayama, Keiko, Nakayama, Keiichi I, Fukasawa, Kenji, Schwab, Manfred, Saya, Hideyuki, Miwa, Masanao  Suppression of centrosome amplification after DNA damage depends on p27 accumulation.  Cancer Res  2006  66:4020-9  PubMed ID: 16618721   DOI: 10.1158/0008-5472.CAN-05-3250

8877  Kubo Y, Akiyama M, Fukada Y, Okano T.  Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland.  J. Neurochem.  2006  97:1155-65  PubMed ID: 16686694   DOI: 10.1111/j.1471-4159.2006.03826.x

8903  Matsui K, Horiuchi S, Sando S, Sera T, Aoyama Y.  RNAi silencing of exogenous and endogenous reporter genes using a macrocyclic octaamine as a "compact" siRNA carrier. Studies on the nonsilenced residual activity.  Bioconjug. Chem.  2006  17:132-8  PubMed ID: 16417261   DOI: 10.1021/bc050112l

6448  Takeuchi T, Adachi Y, Sonobe H, Furihata M, Ohtsuki Y.  A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion.  Oncogene  2006  25(53):7059-69  PubMed ID: 16715130   DOI: 10.1038/sj.onc.1209688

10355  Osamu Hashimoto, Yuuki Ushiro, Kazunari Sekiyama, Osamu Yamaguchi, Kazuki Yoshioka, Ken-ichiro Mutoh, Yoshihisa Hasegawa  Impaired Growth of Pancreatic Exocrine Cells in Transgenic Mice Expressing Human Activin betaE Subunit  Biochem Biophys Res Commun  2006  341(2):416-24  PubMed ID: 16426570   DOI: 10.1016/j.bbrc.2005.12.205

13652  Ishii N, Ozaki K, Sato H, Mizuno H, Susumu Saito, Takahashi A, Miyamoto Y, Ikegawa S, Kamatani N, Hori M, Satoshi Saito, Nakamura Y, Tanaka T.  Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction  J Hum Genet  2006  51(12):1087-1099.  PubMed ID: 17066261   DOI: 10.1007/s10038-006-0070-9

2993  Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M  Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.  J Biol Chem  2005  280:28044-52  PubMed ID: 15927955   DOI: 10.1074/jbc.M503343200

3183  Hata, Kenji, Nishimura, Riko, Ueda, Mio, Ikeda, Fumiyo, Matsubara, Takuma, Ichida, Fumitaka, Hisada, Kunihiro, Nokubi, Takashi, Yamaguchi, Akira, Yoneda, Toshiyuki  A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.  Mol Cell Biol  2005  25:1971-9  PubMed ID: 15713650   DOI: 10.1128/MCB.25.5.1971-1979.2005

3350  Nagayoshi, Ryusaku, Nagai, Taku, Matsushita, Kakushi, Sato, Katsuaki, Sunahara, Nobuhiko, Matsuda, Takemasa, Nakamura, Tadashi, Komiya, Setsuro, Onda, Masanori, Matsuyama, Takami  Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages.  Arthritis Rheum  2005  52:2666-75  PubMed ID: 16142741   DOI: 10.1002/art.21228

3349  Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, Yamanaka M, Eda S, Beppu M.  A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells.  J Biol Chem  2005  280(47):39284-93  PubMed ID: 16135517   DOI: 10.1074/jbc.M505275200

16809  Satoh J, Onoue H, Arima K, Yamamura T.  Nogo-A and nogo receptor expression in demyelinating lesions of multiple sclerosis  J Neuropathol Exp Neurol  2005  64(2):129-38  PubMed ID: 15751227   DOI: 10.1093/jnen/64.2.129

16811  Satoh J, Onoue H, Arima K, Yamamura T.  The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein  J Neuropathol Exp Neurol  2005  64(10):858-68  PubMed ID: 16215457   DOI: 10.1097/01.jnen.0000182979.56612.08

17366  Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex  Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex  Gastroenterology  2005  128(7):1919-36  PubMed ID: 15940627   DOI: 10.1053/j.gastro.2005.03.007

2515  Sugiura T, Nagano Y, Inoue T, Hirotani K.  A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma.  Biochem Biophys Res Commun  2004  315(1):204-11  PubMed ID: 15013446   DOI: 10.1016/j.bbrc.2004.01.035

9358  Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, Kurimoto M.  Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.  In Vitro Cell. Dev. Biol. Anim.  2003  39:80-8  PubMed ID: 12892531   DOI: 10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2

3593  Matsuguchi T, Masuda A, Sugimoto K, Nagai Y, Yoshikai Y.  JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation.  EMBO J  2003  22(17):4455-64  PubMed ID: 12941697   DOI: 10.1093/emboj/cdg438

9040  Byoung-Hee Lee, Kumiko Yoshimatsu, Akihiko Maeda, Kazuhiko Ochiai, Masami Morimatsu, Koichi Araki, Michiko Ogino, Shigeru Morikawa, Jiro Arikawa  Association of the Nucleocapsid Protein of the Seoul and Hantaan Hantaviruses With Small Ubiquitin-Like modifier-1-related Molecules  Virus Res  2003  98 (1), 83-91  PubMed ID: 14609633   DOI: 10.1016/j.virusres.2003.09.001

10894  Hiroyuki Oshiumi, Miwa Sasai, Kyoko Shida, Takashi Fujita, Misako Matsumoto, Tsukasa Seya  TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-Like Receptor 4 TICAM-1 That Induces Interferon-Beta  J Biol Chem  2003  278(50):49751-62  PubMed ID: 14519765   DOI: 10.1074/jbc.M305820200

14330  Sato T, Odagiri H, Ikenaga SK, Maruyama M, Sasaki M.  Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor  Cancer Sci  2003  94(5):467-72  PubMed ID: 12824895   DOI: 10.1111/j.1349-7006.2003.tb01466.x

15615  Masami Ishido, Junko Sayato-Suzuki  Epitope-Tagged Metallothionein: Its Biochemical and Immunocytochemical Applications.  Journal of Health Science  2003  49:156-159    DOI: 10.1248/jhs.49.156

16534  Miyagawa Y, Ohguro H, Odagiri H, Maruyama I, Maeda T, Maeda A, Sasaki M, Nakazawa M.  Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines  Biochem Biophys Res Commun  2003  300(3):669-73  PubMed ID: 12507501   DOI: 10.1016/s0006-291x(02)02888-7

16939  Nishimura R, Hata K, Harris SE, Ikeda F, Yoneda T.  Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12  Bone  2002  31(2):303-12  PubMed ID: 12151083   DOI: 10.1016/s8756-3282(02)00826-8

17289  Irie N, Sakai N, Ueyama T, Kajimoto T, Shirai Y, Saito N.  Subtype- and species-specific knockdown of PKC using short interfering RNA  Biochem Biophys Res Commun  2002  298(5):738-43  PubMed ID: 12419315   DOI: 10.1016/s0006-291x(02)02531-7

13726  Naishiro Y, Yamada T, Takaoka AS, Hayashi R, Hasegawa F, Imai K, Hirohashi S.  Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation  Cancer Res  2001  61(6):2751-8  PubMed ID: 11289158

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3526  Murakami M, Shimbara S, Kambe T, Kuwata H, Winstead MV, Tischfield JA, Kudo I.  The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2.  J Biol Chem  1998  273(23):14411-23  PubMed ID: 9603953   DOI: 10.1074/jbc.273.23.14411