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Cell No. : Cell Name
RCB1637 : 293  update : 2024/05/15
CommentA human cell line derived from kidney of a fetus. Transformed with sheared human Ad5 DNA. Sensitive to human adenoviruses and adenovirus DNA. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECACC 85120602 prior to order.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85120602 prior to order.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor ECACC
Year of deposit 2000
Another name HEK293
Animal _human < Mammals
Genus Homo
Species sapiens
Age at sampling embryo
Tissue kidney
Classification transformed
History overseas, ECACC -> Riken cell bank
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0045
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
Chromosome mode 63-71(50) : /65(5),66(5),67(8),68(10),69(10),70(8)/
STR(human) OK
Reference information Reference 3
User's Publication 313

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4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220   DOI: 10.1016/0042-6822(78)90003-x
2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862   DOI: 10.1016/0042-6822(77)90428-7
2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304   DOI: 10.1099/0022-1317-36-1-59

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User's Publication
19831  Yamaguchi F, Sakane H, Akasaki K.  Comparative study of the steady-state subcellular distribution of lysosome-associated membrane glycoprotein-2 (LAMP-2) isoforms with GYXXΦ-type tyrosine-based motifs that interact differently with four adaptor protein (AP) complexes  J Biochem  2024  175(3):275-287  PubMed ID: 37983719   DOI: 10.1093/jb/mvad096
19873  Kataoka H, Akiyoshi T, Uchida Y, Imaoka A, Terasaki T, Ohtani H.  The effects of N-glycosylation on the expression and transport activity of OATP1A2 and OATP2B1  J Pharm Sci  2024  S0022-3549(24)00058-3  PubMed ID: 38432624   DOI: 10.1016/j.xphs.2024.02.012
19956  Mixich L, Boonstra E, Masuda K, Li SW, Nakashima Y, Meng F, Sakata M, Goda T, Uchida S, Cabral H.  Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo  Biomacromolecules  2024  Jan 5  PubMed ID: 38181450   DOI: 10.1021/acs.biomac.3c01102
21560  Wang A, Uchida K, Yokoyama A, Higashino F, Yasuda M.  Human adenovirus oncolytic properties and the inhibitory role of E4 orf4 and E4 orf6/7 on endogenously activated NF-κB.  Biochem Biophys Rep  2024  37:101616  PubMed ID: 38205184   DOI: 10.1016/j.bbrep.2023.101616
21700  Katayama K, Ito J, Murakami R, Yamashita A, Sasajima H, Narahashi S, Chiba J, Yamamoto I, Fujii W, Tochigi Y, Suzuki H.  Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.  Mamm Genome  2024    PubMed ID: 38658415   DOI: 10.1007/s00335-024-10041-8
21741  Kato S, Tamura K, Masuda Y, Konishi M, Yamanaka K, Oikawa T.  A novel type IIb L-asparaginase from Latilactobacillus sakei LK-145: characterization and application.  Arch Microbiol  2024  206(6):266  PubMed ID: 38761213   DOI: 10.1007/s00203-024-03979-5
17776  Arasawa T, Hiwasa T, Kagaya A, Maruyama T, Uesato M, Kano M, Kobayashi S, Takizawa H, Iwase K, Nomura F, Matsushita K, Matsubara H.  Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels  BMC Cancer  2023  23(1):356  PubMed ID: 37072777   DOI: 10.1186/s12885-023-10845-y
17778  Shinya Usui, Qiunan Zhu, Hisakazu Komori, Yui Iwamoto, Takumi Nishiuchi, Yoshiyuki Shirasaka, Ikumi Tamai  Apple-derived extracellular vesicles modulate the expression of human intestinal bile acid transporter ASBT/SLC10A2 via downregulation of transcription factor RARα  Drug Metabolism and Pharmacokinetics  2023      DOI: 10.1016/j.dmpk.2023.100512
19535  Yan J, Zhang H, Tomochika Y, Chen B, Ping Y, Islam MS, Aramaki S, Sato T, Nagashima Y, Nakamura T, Kahyo T, Kaneda D, Ogawa K, Yoshida M, Setou M.  UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3  Biomedicines  2023  11(9):2491  PubMed ID: 37760932   DOI: 10.3390/biomedicines11092491
19666  Aso A, Nabetani H, Matsuura Y, Kadonaga Y, Shirakami Y, Watabe T, Yoshiya T, Mochizuki M, Ooe K, Kawakami A, Jinno N, Toyoshima A, Haba H, Wang Y, Cardinale J, Giesel FL, Shimoyama A, Kaneda-Nakashima K, Fukase K.  Evaluation of Astatine-211-Labeled Fibroblast Activation Protein Inhibitor (FAPI): Comparison of Different Linkers with Polyethylene Glycol and Piperazine  Int J Mol Sci  2023  24(10):8701  PubMed ID: 37240044   DOI: 10.3390/ijms24108701
19686  Takeuchi M, Nishisho T, Toki S, Kawaguchi S, Tamaki S, Oya T, Uto Y, Katagiri T, Sairyo K.  Blue light induces apoptosis and autophagy by promoting ROS-mediated mitochondr  Cancer Med  2023  12(8):9668-9683  PubMed ID: 36722116   DOI: 10.1002/cam4.5664
19701  Yamamoto R, Segawa R, Liu J, Isaji T, Gu J, Hiratsuka M, Hirasawa N.  Effect of N-glycosylation on constitutive signal transduction by mutated cytokine receptor-like factor 2  Biochim Biophys Acta Gen Subj  2023  1867(11):130465  PubMed ID: 37748663   DOI: 10.1016/j.bbagen.2023.130465
19785  Yamamoto H, Tanaka Y, Sawada M, Kihara S.  ERRα Attenuates Vascular Inflammation via Enhanced NFκB Degradation Pathway  Endocrinology  2023  164(3):bqac212  PubMed ID: 36534970   DOI: 10.1210/endocr/bqac212
19803  Murase W, Kubota A, Ikeda-Araki A, Terasaki M, Nakagawa K, Shizu R, Yoshinari K, Kojima H.  Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays  Toxicology  2023  494:153577  PubMed ID: 37302725   DOI: 10.1016/j.tox.2023.153577
19809  Tezuka M, Yonekubo-Awaka S, Tamai Y, Tsuchioka K, Kobayashi K, Kuramochi Y, Tatemichi S, Nagasawa T, Kiguchi S.  Suppression of hypothalamic-pituitary-gonadal function by linzagolix in benign prostatic hyperplasia and polycystic ovary syndrome animal models  Clin Exp Pharmacol Physiol  2023  50(11):914-923  PubMed ID: 37622483   DOI: 10.1111/1440-1681.13817
19876  Maekawa K, Ishizawa M, Ikawa T, Sajiki H, Matsumoto T, Tokiwa H, Makishima M, Yamada S.  Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D3 Derivatives with Structure-Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs  Biomolecules  2023  13(7):1082  PubMed ID: 37509118   DOI: 10.3390/biom13071082
19899  Nakamura T, Sugeno N, Hasegawa T, Ikeda K, Yoshida S, Ishiyama S, Sato K, Takeda A, Aoki M.  Alpha-synuclein promotes PRMT5-mediated H4R3me2s histone methylation by interacting with the BAF complex  FEBS J  2023  Dec 17  PubMed ID: 38105619   DOI: 10.1111/febs.17037
19947  Moriizumi H, Kubota Y, Tsuchiya T, Naka R, Takekawa M.  Caspase 3-specific cleavage of MEK1 suppresses ERK signaling and sensitizes cells to stress-induced apoptosis  FEBS Open Bio  2023  13(4):684-700  PubMed ID: 36776127   DOI: 10.1002/2211-5463.13574
19987  Miyajima Y, Noguchi-Yachide T, Ochiai K, Fujii S.  Physicochemical characterization of B-hydroxyphenyl phosphine borane derivatives and their evaluation as nuclear estrogen receptor ligands  RSC Med Chem  2023  15(1):119-12  PubMed ID: 38283218   DOI: 10.1039/d3md00350g
21018  Nakashima KI, Okamura M, Matsumoto I, Kameda N, Tsuboi T, Yamaguchi E, Itoh A, Inoue M.  Regulation of adipogenesis through retinoid X receptor and/or peroxisome proliferator-activated receptor by designed lignans based on natural products in 3T3-L1 cells.  J Nat Med  2023    PubMed ID: 36607539   DOI: 10.1007/s11418-022-01674-7
21023  Nakamura Y, Aizawa C, Kawata H, Nakanishi T.  N-glycosylation Modifies Prostaglandin E2 Uptake by Reducing Cell Surface Expression of SLCO2A1.  Prostaglandins Other Lipid Mediat  2023  106714  PubMed ID: 36706979   DOI: 10.1016/j.prostaglandins.2023.106714
21041  Shiraki A, Shimizu S.  The molecular associations in clathrin-coated pit regulate β-arrestin-mediated MAPK signaling downstream of μ-opioid receptor.  Biochem Biophys Res Commun  2023  640:64-72  PubMed ID: 36502633   DOI: 10.1016/j.bbrc.2022.11.098
21068  Yamakado N, Okuda S, Tobiume K, Uetsuki R, Ono S, Mizuta K, Nakagawa T, Aikawa T.  Chemical inhibition of LSD1 leads to epithelial to mesenchymal transition in vitro of an oral squamous cell carcinoma OM-1 cell line via release from LSD1-dependent suppression of ZEB1.  Biochem Biophys Res Commun  2023  647:23-29  PubMed ID: 36709669   DOI: 10.1016/j.bbrc.2023.01.062
21100  Suzuki Y, Nakamoto C, Watanabe-Iida I, Watanabe M, Takeuchi T, Sasaoka T, Abe M, Sakimura K.  Quantitative analysis of NMDA receptor subunits proteins in mouse brain.  Neurochem Int  2023  105517  PubMed ID: 36913980   DOI: 10.1016/j.neuint.2023.105517
21116  Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y.  Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.  Cells  2023  12(4)  PubMed ID: 36831269   DOI: 10.3390/cells12040602
21153  Yang W, Miyazaki T, Nakagawa Y, Boonstra E, Masuda K, Nakashima Y, Chen P, Mixich L, Barthelmes K, Matsumoto A, Mi P, Uchida S, Cabral H.  Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π-π stacking-assisted micellar assembly.  Sci Technol Adv Mater  2023  24(1):2170164  PubMed ID: 36950277   DOI: 10.1080/14686996.2023.2170164
21214  Ohba K, Sehara Y, Enoki T, Mineno J, Ozawa K, Mizukami H.  Adeno-associated virus vector system controlling capsid expression improves viral quantity and quality.  iScience  2023  26(4):106487  PubMed ID: 37096037   DOI: 10.1016/j.isci.2023.106487
21246  Ishiyama S, Hasegawa T, Sugeno N, Kobayashi J, Yoshida S, Miki Y, Wakabayashi K, Fukuda M, Kawata Y, Nakamura T, Sato K, Ezura M, Kikuchi A, Takeda A, Aoki M.  Sortilin acts as an endocytic receptor for α-synuclein fibril.  FASEB J  2023  37(7):e23017  PubMed ID: 37272890   DOI: 10.1096/fj.202201605RR
21270  Yamaguchi S, Kamino M, Hamamura M, Otsuguro KI.  The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells.  PLoS One  2023  18(6):e0287249  PubMed ID: 37352201   DOI: 10.1371/journal.pone.0287249
21333  Kogaki T, Hase H, Tanimoto M, Tashiro A, Kitae K, Ueda Y, Jingushi K, Tsujikawa K.  ALKBH4 is a novel enzyme that promotes translation through modified uridine regulation.  J Biol Chem  2023  105093  PubMed ID: 37507018   DOI: 10.1016/j.jbc.2023.105093
21384  Nishida K, Wang G, Kobatake E, Mie M.  Sensitive Detection of Tumor Cells Using Protein Nanoparticles with Multiple Displays of DNA Aptamers and Bioluminescent Reporters.  ACS Biomater Sci Eng  2023    PubMed ID: 37642536   DOI: 10.1021/acsbiomaterials.3c00712
21453  Yajima K, Akiyoshi T, Sakamoto K, Suzuki Y, Oka T, Imaoka A, Yamamura H, Kurokawa J, Ohtani H.  Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach.  J Pharmacol Sci  2023  153(3):153-160  PubMed ID: 37770156   DOI: 10.1016/j.jphs.2023.08.008
21467  Suzuki S, Saito S, Narushima Y, Kodani S, Kagaya N, Suenaga H, Shin-Ya K, Arai MA.  Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation.  J Antibiot (Tokyo)  2023    PubMed ID: 37938761   DOI: 10.1038/s41429-023-00673-4
21485  Zhao X, Ma D, Ishiguro K, Saito H, Akichika S, Matsuzawa I, Mito M, Irie T, Ishibashi K, Wakabayashi K, Sakaguchi Y, Yokoyama T, Mishima Y, Shirouzu M, Iwasaki S, Suzuki T, Suzuki T.  Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.  Cell  2023    PubMed ID: 37992713   DOI: 10.1016/j.cell.2023.10.026
21508  Kenji Ohba, Hiroaki Mizukami  Protocol for producing an adeno-associated virus vector by controlling capsid expression timing  STAR Protocols  2023  4:102542  PubMed ID: 38103199   DOI: 10.1016/j.xpro.2023.102542
21534  Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Johnson EL, Harada Y, Tamura JI, Taniguchi N.  Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model.  J Biol Chem  2023  299(8):105052  PubMed ID: 37454739   DOI: 10.1016/j.jbc.2023.105052
17537  Emiko Kinoshita-Kikuta, Yoko Ino, Yayoi Kimura, Tomoko Akiyama, Eiji Kinoshita, Tohru Koike  Use of Escherichia coli expression system for analyzing kinase motifs  Journal of Electrophoresis  2022  66:13-20    DOI: 10.2198/jelectroph.66.13
17583  Han H, Akiyoshi T, Morita T, Kataoka H, Katayama K, Yajima K, Imaoka A, Ohtani H.  Comparison of the transport kinetics of fexofenadine and its pH dependency among OATP1A2 genetic variants  Drug Metab Pharmacokinet  2022  47:100470  PubMed ID: 36116173   DOI: 10.1016/j.dmpk.2022.100470
17609  Yoshihara A, Kawasaki H, Masuno H, Takada K, Numoto N, Ito N, Hirata N, Kanda Y, Ishizawa M, Makishima M, Kagechika H, Tanatani A.  Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists  Biomolecules  2022  12(1):130  PubMed ID: 35053278   DOI: 10.3390/biom12010130
17708  Nakamura Y, Kozakai H, Nishio T, Yoshida K, Nakanishi T.  Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1  Drug Metab Pharmacokinet  2022  44:100452  PubMed ID: 35299026   DOI: 10.1016/j.dmpk.2022.100452
17798  Chen P, Yang W, Hong T, Miyazaki T, Dirisala A, Kataoka K, Cabral H.  Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC  Biomaterials  2022  288:121748  PubMed ID: 36038419   DOI: 10.1016/j.biomaterials.2022.121748
15439  Shams R, Matsukawa A, Ochi Y, Ito Y, Miyatake H.  In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1  J Med Chem  2022  Jun 30  PubMed ID: 34191518   DOI: 10.1021/acs.jmedchem.1c00536
20553  Urabe T, Miyoshi H, Narasaki S, Yanase Y, Uchida K, Noguchi S, Hide M, Tsutsumi YM, Sakai N.  Characterization of intracellular calcium mobilization induced by remimazolam, a newly approved intravenous anesthetic.  PLoS One  2022  17(2):e0263395  PubMed ID: 35104283   DOI: 10.1371/journal.pone.0263395
16391  Sakamoto T, Yu Z, Otani Y.  Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells  Anal Chem  2022  Mar 2  PubMed ID: 35234461   DOI: 10.1021/acs.analchem.1c04804
20612  Yamatoya K, Nagai Y, Teramoto N, Kang W, Miyado K, Nakata K, Yagi T, Miyamoto Y.  Cryopreservation of undifferentiated and differentiated human neuronal cells.  Regen Ther  2022  19:58-68  PubMed ID: 35059480   DOI: 10.1016/j.reth.2021.12.007
20616  Liu JY, Inoshita T, Shiba-Fukushima K, Yoshida S, Ogata K, Ishihama Y, Imai Y, Hattori N.  Ubiquitination at the lysine 27 residue of the parkin ubiquitin-like domain is suggestive of a new mechanism of parkin activation.  Hum Mol Genet  2022    PubMed ID: 35313349   DOI: 10.1093/hmg/ddac064
20649  Liu Y, Nisisako T.  Microfluidic generation of monodispersed Janus alginate hydrogel microparticles using water-in-oil emulsion reactant.  Biomicrofluidics  2022  16(2):024101  PubMed ID: 35282035   DOI: 10.1063/5.0077916
20657  Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y.  Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.  Biochem Biophys Rep  2022  29:101223  PubMed ID: 35146136   DOI: 10.1016/j.bbrep.2022.101223
20701  Yonezawa H, Ikeda A, Takahashi R, Endo H, Sugawara Y, Goto M, Kanno M, Ogawa S, Nakamura K, Ujiie H, Iwatsuki M, Hirose T, Sunazuka T, Uehara Y, Nishiya N.  Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases.  iScience  2022  25(3):103912  PubMed ID: 35530256   DOI: 10.1016/j.isci.2022.103912
20774  Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.  Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.  Nat Commun  2022  13(1):4063  PubMed ID: 35831322   DOI: 10.1038/s41467-022-31690-w
20796  Honda T, Kawasaki N, Yanagihara R, Tamura R, Murakami K, Ichimiya T, Matsumoto N, Nishihara S, Yamamoto K.  Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9).  PLoS One  2022  17(7):e0268485  PubMed ID: 35901072   DOI: 10.1371/journal.pone.0268485
20807  Ertunc N, Phitak T, Wu D, Fujita H, Hane M, Sato C, Kitajima K.  Sulfation of sialic acid is ubiquitous and essential for vertebrate development.  Sci Rep  2022  12(1)  PubMed ID: 35864127   DOI: 10.1038/s41598-022-15143-4
20816  Krama A, Tokura N, Isoda H, Shigemori H, Miyamae Y.  Cyanidin 3-Glucoside Induces Hepatocyte Growth Factor in Normal Human Dermal Fibroblasts through the Activation of β2-Adrenergic Receptor.  ACS Omega  2022  7(26):22889-22895  PubMed ID: 35811916   DOI: 10.1021/acsomega.2c02659
20890  Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E.  Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling.  Nat Commun  2022  13(1):6092  PubMed ID: 36241662   DOI: 10.1038/s41467-022-33842-4
20897  Ito M, Maejima Y, Nishimura K, Nakae Y, Ono A, Iwaki-Egawa S.  A role for N-glycosylation in active adenosine deaminase 2 production.  Biochim Biophys Acta Gen Subj  2022  1866(12):130237  PubMed ID: 36029899   DOI: 10.1016/j.bbagen.2022.130237
20923  Isobe A, Arai Y, Kuroda D, Okumura N, Ono T, Ushiba S, Nakakita SI, Daidoji T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y.  ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner.  Commun Biol  2022  5(1):1188  PubMed ID: 36335195   DOI: 10.1038/s42003-022-04170-6
20954  Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M.  ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II.  Nat Commun  2022  13(1):7476  PubMed ID: 36463234   DOI: 10.1038/s41467-022-35230-4
21000  Miyoshi K, Shimizu S, Shiraki A, Egi M.  Ubiquitination of the μ-opioid receptor regulates receptor internalization without affecting Gi/o-mediated intracellular signaling or receptor phosphorylation.  Biochem Biophys Res Commun  2022  643:96-104  PubMed ID: 36592585   DOI: 10.1016/j.bbrc.2022.12.077
20101  Matsuo T, Isosaka T, Hayashi Y, Tang L, Doi A, Yasuda A, Hayashi M, Lee CY, Cao L, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu Q, Kobayakawa R, Kobayakawa K.  Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.  Nat Commun  2021  12(1):2074  PubMed ID: 33824316   DOI: 10.1038/s41467-021-22205-0
20182  Takahashi K, Araki K, Miyamoto H, Shirakawa R, Yoshida T, Wakamori M.  Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization.  Front Pharmacol  2021  12:672157  PubMed ID: 34093200   DOI: 10.3389/fphar.2021.672157
20187  Miki T, Nakai T, Hashimoto M, Kajiwara K, Tsutsumi H, Mihara H.  Intracellular artificial supramolecules based on de novo designed Y15 peptides.  Nat Commun  2021  12(1):3412  PubMed ID: 34099696   DOI: 10.1038/s41467-021-23794-6
20197  Ju N, Hayashi H, Shimamura M, Yoshida S, Nakamaru R, Nakagami H, Morishita R, Rakugi H.  Prevention of Acute Lung Injury by a Novel CD14-Inhibitory Receptor Activator of the NF-κB Ligand Peptide in Mice.  Immunohorizons  2021  5(6):438-447  PubMed ID: 34131020   DOI: 10.4049/immunohorizons.2000112
20217  Takashima S, Kurogochi M, Tsukimura W, Mori M, Osumi K, Sugawara SI, Amano J, Mizuno M, Takada Y, Matsuda A.  Preparation and biological activities of anti-HER2 monoclonal antibodies with multi-branched complex-type N-glycans.  Glycobiology  2021    PubMed ID: 34192331   DOI: 10.1093/glycob/cwab064
20272  Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.  Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.  Sci Rep  2021  11(1):13471  PubMed ID: 34188113   DOI: 10.1038/s41598-021-92860-2
15274  Yasuda K, Matsubara T, Shirakawa T, Kawamoto T, Kokabu S.  Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos  Bone Rep  2021  5:101114  PubMed ID: 34401407   DOI: 10.1016/j.bonr.2021.101114
15284  Yoshiko Iizuka, Kinuko Inomata, Risako Nohara, Akimitsu Miyawaki and Yoshifumi Watanabe  Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus  International Journal of Herbal Medicine  2021  9(3):54-60   
20357  Watanabe Y, Sugano E, Tabata K, Hatakeyama A, Sakajiri T, Fukuda T, Ozaki T, Suzuki T, Sayama T, Tomita H.  Development of an optogenetic gene sensitive to daylight and its implications in vision restoration.  NPJ Regen Med  2021  6(1):64  PubMed ID: 34650094   DOI: 10.1038/s41536-021-00177-5
15664  Tabata K, Sugano E, Hatakeyama A, Watanabe Y, Suzuki T, Ozaki T, Fukuda T, Tomita H.  Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene  Int J Mol Sci   2021  ;22(13):6732  PubMed ID: 34201658   DOI: 10.3390/ijms22136732
20417  Shams R, Ito Y, Miyatake H.  Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays.  Int J Mol Sci  2021  22(16)  PubMed ID: 34445471   DOI: 10.3390/ijms22168766
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