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Cell No. : Cell Name
RCB1637 : 293  update : 2021/11/30
CommentA human cell line derived from kidney of a fetus. Transformed with sheared human Ad5 DNA. Sensitive to human adenoviruses and adenovirus DNA. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA 85120602 prior to order.
Comment from the depositor
Terms and conditionsCan be used only by not-for-profit entities and only for not-for-profit academic purposes. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85120602 prior to order.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor ECACC
Year of deposit 2000
Another name HEK293
Animal _human < Mammals
Genus Homo
Species sapiens
Age at sampling embryo
Tissue kidney
Classification transformed
History overseas, ECACC -> Riken cell bank
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0045
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
Chromosome mode 63-71(50) : /65(5),66(5),67(8),68(10),69(10),70(8)/
STR(human) OK
Reference information Reference 3
User's Publication 209


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Reference
4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220
2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862
2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304

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User's Publication
13351  Matsumoto Y, Kishida K, Matsumoto M, Matsuoka S, Kohyama M, Suenaga T, Arase H.  A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice.  Biochem Biophys Res Commun  2021    PubMed ID: 33208230
20101  Matsuo T, Isosaka T, Hayashi Y, Tang L, Doi A, Yasuda A, Hayashi M, Lee CY, Cao L, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, Liu Q, Kobayakawa R, Kobayakawa K.  Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.  Nat Commun  2021  12(1):2074  PubMed ID: 33824316
20182  Takahashi K, Araki K, Miyamoto H, Shirakawa R, Yoshida T, Wakamori M.  Capsaicin and Proton Differently Modulate Activation Kinetics of Mouse Transient Receptor Potential Vanilloid-1 Channel Induced by Depolarization.  Front Pharmacol  2021  12:672157  PubMed ID: 34093200
20187  Miki T, Nakai T, Hashimoto M, Kajiwara K, Tsutsumi H, Mihara H.  Intracellular artificial supramolecules based on de novo designed Y15 peptides.  Nat Commun  2021  12(1):3412  PubMed ID: 34099696
20197  Ju N, Hayashi H, Shimamura M, Yoshida S, Nakamaru R, Nakagami H, Morishita R, Rakugi H.  Prevention of Acute Lung Injury by a Novel CD14-Inhibitory Receptor Activator of the NF-κB Ligand Peptide in Mice.  Immunohorizons  2021  5(6):438-447  PubMed ID: 34131020
20217  Takashima S, Kurogochi M, Tsukimura W, Mori M, Osumi K, Sugawara SI, Amano J, Mizuno M, Takada Y, Matsuda A.  Preparation and biological activities of anti-HER2 monoclonal antibodies with multi-branched complex-type N-glycans.  Glycobiology  2021    PubMed ID: 34192331
15439  Shams R, Matsukawa A, Ochi Y, Ito Y, Miyatake H.  In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1  J Med Chem  2021  Jun 30  PubMed ID: 34191518
15274  Yasuda K, Matsubara T, Shirakawa T, Kawamoto T, Kokabu S.  Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos  Bone Rep  2021  5:101114  PubMed ID: 34401407
15284  Yoshiko Iizuka, Kinuko Inomata, Risako Nohara, Akimitsu Miyawaki and Yoshifumi Watanabe  Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus  International Journal of Herbal Medicine  2021  9(3):54-60 
20357  Watanabe Y, Sugano E, Tabata K, Hatakeyama A, Sakajiri T, Fukuda T, Ozaki T, Suzuki T, Sayama T, Tomita H.  Development of an optogenetic gene sensitive to daylight and its implications in vision restoration.  NPJ Regen Med  2021  6(1):64  PubMed ID: 34650094
15664  Tabata K, Sugano E, Hatakeyama A, Watanabe Y, Suzuki T, Ozaki T, Fukuda T, Tomita H.  Phototoxicities Caused by Continuous Light Exposure Were Not Induced in Retinal Ganglion Cells Transduced by an Optogenetic Gene  Int J Mol Sci   2021  ;22(13):6732  PubMed ID: 34201658
20417  Shams R, Ito Y, Miyatake H.  Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays.  Int J Mol Sci  2021  22(16)  PubMed ID: 34445471
20441  Hongprasit A, Okamoto Y, Toida T, Ogra Y.  Comparison of quantification of selenocyanate and thiocyanate in cultured mammalian cells between HPLC-fluorescence detector and HPLC-inductively coupled plasma mass spectrometer.  J Chromatogr B Analyt Technol Biomed Life Sci  2021  1181:122924  PubMed ID: 34508979
6934  Baba K, Kuwada S, Nakao A, Li X, Okuda N, Nishida A, Mitsuda S, Fukuoka N, Kakeya H, Kataoka T.  Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.  Histochem Cell Biol  2020    PubMed ID: 31907597
9190  Rui Jiang, Ziyan Zhang, Zhiwei Zhong, Yuxuan Dai, Guangyao Liu, Chao Zhang  Phosphorylation of Histone H4 at Serine 1 Is Associated With GCN5 and Mediates Autophagy in Osteosarcoma Bone Cell Lines  J Cell Physiol   2020    PubMed ID: 31903552
10370  Yusuke Higuchi, Jun-Ichirou Yasunaga, Yu Mitagami, Hirotake Tsukamoto, Kazutaka Nakashima, Koichi Ohshima, Masao Matsuoka  HTLV-1 Induces T Cell Malignancy and Inflammation by Viral Antisense Factor-Mediated Modulation of the Cytokine Signaling  Proc Natl Acad Sci U S A  2020  117(24):13740-13749  PubMed ID: 32471947
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870
12113  Horii T, Morita S, Hino S, Kimura M, Hino Y, Kogo H, Nakao M, Hatada I.  Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome.  Genome Biol.  2020    PubMed ID: 32234052
12360  Morita T, Akiyoshi T, Sato R, Katayama K, Yajima K, Kataoka H, Imaoka A, Sugimoto Y, Ohtani H.  pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2  Drug Metab Pharmacokinet  2020  35(2):220-227  PubMed ID: 31974044
13037  Ueda M, Matsuki T, Fukada M, Eda S, Toya A, Iio A, Tabata H, Nakayama A.  Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.  Mol Brain  2020    PubMed ID: 32448361
13046  Ouchi K, Miyachi M, Yagyu S, Kikuchi K, Kuwahara Y, Tsuchiya K, Iehara T, Hosoi H.  Oncogenic role of HMGA2 in fusion-negative rhabdomyosarcoma cells.  Cancer Cell Int  2020    PubMed ID: 32489328
13073  Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T.  Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling.  Free Radic Biol Med  2020    PubMed ID: 32553752
13095  Mai NNH, Yamaguchi Y, Choijookhuu N, Matsumoto J, Nanashima A, Takagi H, Sato K, Tuan LQ, Hishikawa Y.  Photodynamic Therapy Using a Novel Phosphorus Tetraphenylporphyrin Induces an Anticancer Effect via Bax/Bcl-xL-related Mitochondrial Apoptosis in Biliary Cancer Cells.  Acta Histochem Cytochem  2020    PubMed ID: 32873990
13115  Urabe T, Yanase Y, Motoike S, Harada K, Hide I, Tanaka S, Tsutsumi YM, Kawamoto M, Sakai N.  Propofol induces the elevation of intracellular calcium via morphological changes in intracellular organelles, including the endoplasmic reticulum and mitochondria.  Eur J Pharmacol  2020    PubMed ID: 32681942
13163  Furuno K, Wang J, Suzuki K, Nakahata M, Sakai S.  Gelatin-Based Electrospun Fibers Insolubilized by Horseradish Peroxidase-Catalyzed Cross-Linking for Biomedical Applications.  ACS Omega  2020    PubMed ID: 32875262
13193  Iio A, Kaji K, Kaji N, Hori M, Yonezawa T, Momoi Y, Maeda S.  Expression analysis of protease-activated receptor-2 in cats.  Vet Immunol Immunopathol  2020    PubMed ID: 32932190
13200  Ago Y, Otsuka H, Sasai H, Abdelkreem E, Nakama M, Aoyama Y, Matsumoto H, Fujiki R, Ohara O, Akiyama K, Fukui K, Watanabe Y, Nakajima Y, Ohnishi H, Ito T, Fukao T.  Japanese patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: In vitro functional analysis of five novel HMGCS2 mutations.  Exp Ther Med  2020    PubMed ID: 32952630
13307  Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y.  CELF2 regulates the species-specific alternative splicing of TREM2.  Sci Rep  2020    PubMed ID: 33093587
13349  Konishi H, Hayashi M, Taniguchi K, Nakamura M, Kuranaga Y, Ito Y, Kondo Y, Sasaki H, Terai Y, Akao Y, Ohmichi M.  The therapeutic potential of exosomal miR-22 for cervical cancer radiotherapy.  Cancer Biol Ther  2020    PubMed ID: 33190594
13584  Uda RM, Yoshida N, Iwasaki T, Hayashi K.  pH-triggered solubility and cytotoxicity changes of malachite green derivatives incorporated in liposomes for killing cancer cells  J Mater Chem B  2020  8(36):8242-8248  PubMed ID: 32794526
13610  Puteri MU, Watanabe Y, Wardhani BWK, Amalia R, Abdelaziz M, Kato M.  PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells  Genes Cells  2020  25(6):375-390  PubMed ID: 32181976
13944  Akaike Y, Chibazakura T.  Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells  Cell Cycle  2020  19(1):84-96  PubMed ID: 31760882
14836  Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M.  Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library  Cell Chem Biol   2020  27(6):708-718.e1  PubMed ID: 32402240
20272  Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.  Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.  Sci Rep  2020  11(1):13471  PubMed ID: 34188113
11179  Ali F, Hossain MS, Sejimo S, Akashi K.  Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells.  Mol. Neurobiol.  2019  56(5):3404-3419  PubMed ID: 30128650
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549
11312  Manabe A, Furukawa C, Hasegawa H, Matsunaga T, Endo S, Ikari A.  Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.  J. Cell. Physiol.  2019    PubMed ID: 30461012
11394  Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H.  Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging.  Cell Metab.  2019    PubMed ID: 30661929
11402  Morita M, Hashimoto O.  Identification and expression of the medaka inhibin βE subunit.  Mol. Biol. Rep.  2019    PubMed ID: 30680594
11412  Zhang W, Matsuo R, Takahara T, Shibata H, Maki M.  High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins.  Methods Mol. Biol.  2019    PubMed ID: 30710293
11411  Zhang W, Takahara T, Achiha T, Shibata H, Maki M.  Cellular Ca2+-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements.  Methods Mol. Biol.  2019    PubMed ID: 30710269
6050  Yokota S, Kuramochi H, Okubo K, Iwaya A, Tsuchiya S, Ichiki T.  Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes.  PLoS One  2019  14(10):e0224091  PubMed ID: 31648253
11580  Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, Yukimori A, Takakura I, Sumimoto H, Fukada T, Azuma M, Akiyama H, Nishimura R, Shimane T, Mishima K.  Sox9 regulates the luminal stem/progenitor cell properties of salivary glands.  Exp. Cell Res.  2019    PubMed ID: 31153924
11586  Ikeda Y, Morita SY, Hatano R, Tsuji T, Terada T.  Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 31176036
11628  Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.  Identification of ryuvidine as a KDM5A inhibitor.  Sci Rep  2019    PubMed ID: 31289306
11800  Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.  Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.  Sci Rep  2019    PubMed ID: 31520002
6899  Miyano K, Shiraishi S, Minami, Sudo Y, Suzuki M, Yokoyama T, Terawaki K, Nonaka M, Murata H, Higami Y, Uezono Y.  Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways.  Int J Mol Sci  2019  20(13):3271  PubMed ID: 31277262
6937  Ryo Muko et al  Cloning and Detection of Equine Histidine-Rich Glycoprotein  Journal of Equine Veterinary Science  2019  73:121-126 
10396  Takahiro Toda, Shinichiro Yamamoto, Noriko Umehara, Yasuo Mori, Minoru Wakamori, Shunichi Shimizu  Protective Effects of Duloxetine Against Cerebral Ischemia-Reperfusion Injury via Transient Receptor Potential Melastatin 2 Inhibition  J Pharmacol Exp Ther  2019  368(2):246-254  PubMed ID: 30523061
10397  Murat Kutluay, Makoto Inoue and Iclal Saracoglu  Assessment of LXRα agonist activity and selective antiproliferative efficacy: a study on different parts of Digitalis species  Turkish Journal of Biochemistry  2019  44 
10400  Shun Adachi  Induction of hierarchy and time through one-dimensional probability space with certain topologies  bioRxiv  2019  September 24 
12328  Ikeda T, Ichikawa K, Shigeto H, Ishida T, Hirota R, Funabashi H, Kuroda A.  Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish  Biosci Biotechnol Biochem  2019  83(12):2272-2275  PubMed ID: 31482750
12353  Li J, Yoshida Y, Kurita M, Usuki T.  Cynaropicrin and inhibition of NF-κB activation: A structure activity relationship study  Bioorg Med Chem Lett  2019  29(12):1518-1521  PubMed ID: 30987894
12359  Nakai S, Uchitomi R, Matsuda R, Onishi T, Hatazawa Y, Kamei Y.  Screening dataset of food components that enhance transcriptional activity of PGC1-beta  Data Brief  2019  23:103814  PubMed ID: 31372459
12361  Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.  Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy  J Neurochem  2019  148(3):373-385  PubMed ID: 30295925
7018  Uchida S, Yoshinaga N, Yanagihara K, Yuba E, Kataoka K, Itaka K.  Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination.  Biomaterials  2018  150:162-170  PubMed ID: 29031816
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781
10620  Nakamura M, Fujita K, Toyoda Y, Takada T, Hasegawa H, Ichida K.  Investigation of the transport of xanthine dehydrogenase inhibitors by the urate transporter ABCG2.  Drug Metab. Pharmacokinet.  2018  33:77-81  PubMed ID: 29342419
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296
11083  Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M.  Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.  Nat Commun  2018  9(1):2049  PubMed ID: 29799007
11158  Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K.  Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting.  Nucleic Acids Res.  2018  46(16):8079-8089  PubMed ID: 30085309
11074  Tsukamoto H, Takeuchi S, Kubota K, Kobayashi Y, Kozakai S, Ukai I, Shichiku A, Okubo M, Numasaki M, Kanemitsu Y, Matsumoto Y, Nochi T, Watanabe K, Aso H, Tomioka Y.  Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation.  J. Biol. Chem.  2018  293(26):10186-10201  PubMed ID: 29760187
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880
11260  Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.  Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.  Mol. Pharm.  2018    PubMed ID: 30359033
11268  Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.  Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.  Cell Rep  2018    PubMed ID: 30380411
11399  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Yuyama K, Nakamura H, Fu Q, Maehara O, Suda G, Sakamoto N.  Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.  Stem Cells Int  2018    PubMed ID: 30675167
4085  Agata Okonska et al  Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy  bioRxiv  2018  July 31 
4101  Takagi M, Kimura K, Nakashima KI, Inoue M.  Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids.  Eur. J. Pharmacol.  2018    PubMed ID: 29248425
4102  Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H.  Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.  PLoS ONE  2018    PubMed ID: 30500824
4103  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N.  Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.  Front Pharmacol  2018    PubMed ID: 30057547
4104  Mizuno H, Taketomi A.  MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro.  BMC Res Notes  2018    PubMed ID: 30064488
4105  Takayama-Ito M, Lim CK, Yamaguchi Y, Posadas-Herrera G, Kato H, Iizuka I, Islam MT, Morimoto K, Saijo M.  Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge.  PLoS Negl Trop Dis  2018    PubMed ID: 29659579
4106  Saifullah, Tsukahara T.  Genotyping of single nucleotide polymorphisms using the SNP-RFLP method.  Biosci Trends  2018    PubMed ID: 30012914
4107  Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.  Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.  Int J Mol Sci  2018    PubMed ID: 30021999
4108  Matsuura M, Ohshima M, Hiruta Y, Nishimura T, Nagase K, Kanazawa H.  LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging.  Int J Mol Sci  2018    PubMed ID: 29865203
14542  Matsubara T, Kokabu S, Nakatomi C, Kinbara M, Maeda T, Yoshizawa M, Yasuda H, Takano-Yamamoto T, Baron R, Jimi E.  The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts  Mol Cell Biol  2018  38(4):e00425-17  PubMed ID: 29158294
14701  Otero R, Ishizawa M, Numoto N, Ikura T, Ito N, Tokiwa H, Mouriño A, Makishima M, Yamada S.  25 S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D 3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex  J Med Chem  2018  61(15):6658-6673  PubMed ID: 29989817
14895  Cheng CC, Tsutsui K, Taguchi T, Sanzen N, Nakagawa A, Kakiguchi K, Yonemura S, Tanegashima C, Keeley SD, Kiyonari H, Furuta Y, Tomono Y, Watt FM, Fujiwara H.  Hair follicle epidermal stem cells define a niche for tactile sensation  Elife  2018  7:e38883  PubMed ID: 30355452
9982  Furukawa C, Fujii N, Manabe A, Matsunaga T, Endo S, Hasegawa H, Ito Y, Yamaguchi M, Yamazaki Y, Ikari A.  Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.  J. Cell. Physiol.  2017  232:2841-2850  PubMed ID: 27925186
9983  Imaizumi Y, Goda T, Schaffhauser DF, Okada JI, Matsumoto A, Miyahara Y.  Proton-sensing transistor systems for detecting ion leakage from plasma membranes under chemical stimuli.  Acta Biomater  2017  50:502-509  PubMed ID: 27956364
10079  Satou K, Mochimaru Y, Nakakura T, Kusada T, Negishi J, Musha S, Yoshimura N, Kato Y, Tomura H.  Easy detection of hormone secretion from LβT2 cells by using Gaussia luciferase.  J. Reprod. Dev.  2017  63:199-204  PubMed ID: 28090002
10393  Yukimori A, Oikawa Y, Morita KI, Nguyen CTK, Harada H, Yamaguchi S, Kayamori K, Yamaguchi A, Ikeda T, Sakamoto K.  Genetic basis of calcifying cystic odontogenic tumors.  PLoS ONE  2017  12:e0180224  PubMed ID: 28658279
10416  Kubota Y, Fujioka K, Takekawa M.  WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins.  PLoS ONE  2017  12:e0180714  PubMed ID: 28686627
10433  Endo-Umeda K, Aoyama A, Shimizu M, Ishikawa M, Hashimoto Y, Yamada S, Makishima M.  1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators.  J. Steroid Biochem. Mol. Biol.  2017  172:136-148  PubMed ID: 28736297
10482  Horie K, Kawakami K, Fujita Y, Sugaya M, Kameyama K, Mizutani K, Deguchi T, Ito M.  Exosomes expressing carbonic anhydrase 9 promote angiogenesis.  Biochem. Biophys. Res. Commun.  2017  492:356-361  PubMed ID: 28851650
10524  Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y.  L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.  JCI Insight  2017  2:  PubMed ID: 28931752
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12231  Osamu Nishimiya, Yoshinao Katsu, Hiroyuki Inagawa, Naoshi Hiramatsu, Takashi Todo, Akihiko Hara  Molecular cloning and characterization of hagfish estrogen receptors  J Steroid Biochem Mol Biol  2017  165(Pt B):190-201  PubMed ID: 27287934
12311  Sourov Chandra 1, Grégory Beaune, Naoto Shirahata, Françoise M Winnik  A one-pot synthesis of water soluble highly fluorescent silica nanoparticles  J Mater Chem B  2017  5(7):1363-1370  PubMed ID: 32264628
14270  Fujiki R, Hijikata A, Shirai T, Okada S, Kobayashi M, Ohara O.  Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation  J Biol Chem  2017  292(15):6240-6254  PubMed ID: 28258222
14485  Orimoto A, Kurokawa M, Handa K, Ishikawa M, Nishida E, Aino M, Mitani A, Ogawa M, Tsuji T, Saito M.  F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-β activity  Arch Oral Biol  2017  79:7-1  PubMed ID: 28282516
14562  Adachi S.  Rigid geometry solves "curse of dimensionality" effects in clustering methods: An application to omics data  PLoS One  2017  12(6):e0179180  PubMed ID: 28614363
14628  Tamura M, Ishizawa M, Isojima T, Özen S, Oka A, Makishima M, Kitanaka S.  Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia  Sci Rep  2017  7(1):5102  PubMed ID: 28698609
14657  Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, Shimomura I.  The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2  J Biol Chem  2017  ;292(19):7840-7849  PubMed ID: 28325833
14705  Tsuda Y, Tanikawa C, Miyamoto T, Hirata M, Yodsurang V, Zhang YZ, Imoto S, Yamaguchi R, Miyano S, Takayanagi H, Kawano H, Nakagawa H, Tanaka S, Matsuda K.  Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells  Sci Rep  2017  7(1):10739  PubMed ID: 28878391
14770  Nagasaki A, T Kijima S, Yumoto T, Imaizumi M, Yamagishi A, Kim H, Nakamura C, Q P Uyeda T.  The Position of the GFP Tag on Actin Affects the Filament Formation in Mammalian Cells.  Cell Struct Funct  2017  42:131-140  PubMed ID: 28855440
7056  Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M.  Forward-genetics analysis of sleep in randomly mutagenized mice.  Nature  2016  539:378-383  PubMed ID: 27806374
7062  Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A, Kunieda T.  Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.  Nat Commun  2016  7:12808  PubMed ID: 27649274
7127  Mimura Y, Kelly RM, Unwin L, Albrecht S, Jefferis R, Goodall M, Mizukami Y, Mimura-Kimura Y, Matsumoto T, Ueoka H, Rudd PM.  Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.  J. Immunol. Methods  2016  428:30-6  PubMed ID: 26627984
7150  Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, Matsuzawa A, Yoshinari K.  PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.  Biochem. J.  2016  473:257-66  PubMed ID: 26574435
9703  Toda T, Yamamoto S, Yonezawa R, Mori Y, Shimizu S.  Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.  Eur. J. Pharmacol.  2016  786:19-28  PubMed ID: 27238971
9708  Tohno M, Shinkai H, Toki D, Okumura N, Tajima K, Uenishi H.  Identification of the Q969R gain-of-function polymorphism in the gene encoding porcine NLRP3 and its distribution in pigs of Asian and European origin.  Immunogenetics  2016  68:693-701  PubMed ID: 27236661
9882  Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Sci Rep  2016  6:35930  PubMed ID: 27775020
8922  Kashima H, Momose F, Umehara H, Miyoshi N, Ogo N, Muraoka D, Shiku H, Harada N, Asai A.  Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity.  PLoS One  2016  11(6):e0156643  PubMed ID: 27284967
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13421  Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T.  Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress  Int J Mol Med  2016  37(6):1611-8  PubMed ID: 27082251
13472  Kaneko Y, Daitoku H, Komeno C, Fukamizu A.  CTF18 interacts with replication protein A in response to replication stress  Mol Med Rep  2016  14(1):367-72  PubMed ID: 27175616
14027  Verdugo M, Ogra Y, Quiroz W.  Mechanisms underlying the toxic effects of antimony species in human embryonic kidney cells (HEK-293) and their comparison with arsenic species  J Toxicol Sci  2016  41(6):783-792  PubMed ID: 27853107
14135  Medina J, Nakagawa Y, Nagasawa M, Fernandez A, Sakaguchi K, Kitaguchi T, Kojima I.  Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose  J Biol Chem   2016  291(44):23126-23135  PubMed ID: 27613866
14203  Yamada H, Tsutsumi K, Nakazawa Y, Shibagaki Y, Hattori S, Ohta Y.  Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10  PLoS One  2016  11(1):e0146593  PubMed ID: 26751795
7128  Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.  Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.  J Pharm Pharm Sci  2015  18:316-27  PubMed ID: 26626238
7210  Shimizu S, Yonezawa R, Negoro T, Yamamoto S, Numata T, Ishii M, Mori Y, Toda T.  Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.  Int. J. Biochem. Cell Biol.  2015  68:119-27  PubMed ID: 26386353
7239  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J.  Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.  Biochim. Biophys. Acta  2015  1850:2159-67  PubMed ID: 26299247
7244  Ishii T, Sato K, Kakumoto T, Miura S, Touhara K, Takeuchi S, Nakata T.  Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.  Nat Commun  2015  6:8021  PubMed ID: 26282514
7289  Miura R, Kooriyama T, Yoneda M, Takenaka A, Doki M, Goto Y, Sanjoba C, Endo Y, Fujiyuki T, Sugai A, Tsukiyama-Kohara K, Matsumoto Y, Sato H, Kai C.  Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.  PLoS Negl Trop Dis  2015  9:e0003914  PubMed ID: 26162094
7316  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.  Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.  Nat Commun  2015  6:7360  PubMed ID: 26059659
7319  Kato T, Yui M, Deo VK, Park EY.  Development of Rous sarcoma Virus-like Particles Displaying hCC49 scFv for Specific Targeted Drug Delivery to Human Colon Carcinoma Cells.  Pharm. Res.  2015  32:3699-707  PubMed ID: 26047779
7338  Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C.  MEK5 suppresses osteoblastic differentiation.  Biochem. Biophys. Res. Commun.  2015  463:241-7  PubMed ID: 25998381
7426  Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.  Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.  J. Cell. Physiol.  2015  230:2510-21  PubMed ID: 25802132
7438  Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M.  DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification.  J. Biosci. Bioeng.  2015  120:463-6  PubMed ID: 25772439
7489  Kamada Y, Kusakabe T, Sugimoto Y.  Amyloidogenic lysozymes accumulate in the endoplasmic reticulum accompanied by the augmentation of ER stress signals.  Biochim. Biophys. Acta  2015  1850:1107-19  PubMed ID: 25659958
7567  Tamura M, Kunihiro S, Hamashima Y, Yoshioka Y, Tone S, Kameda K.  An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells.  Biotechnology Reports  2015  6:45-50 
9407  Michiko Yoshida, Kenji Hata, Rikako Takashima, Koichiro Ono, Eriko Nakamura, Yoshifumi Takahata, Tomohiko Murakami, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda  The Transcription Factor Foxc1 Is Necessary for Ihh-Gli2-regulated Endochondral Ossification  Nat Commun  2015  6:6653  PubMed ID: 25808752
9473  Koichi Fujikawa, Ryo Fukumori, Saki Nakamura, Takaya Kutsukake, Takeshi Takarada, Yukio Yoneda  Potential Interactions of Calcium-Sensitive Reagents With Zinc Ion in Different Cultured Cells  PLoS One  2015  10(5):e0127421  PubMed ID: 26010609
14963  Togami K, Miyao A, Miyakoshi K, Kanehira Y, Tada H, Chono S.  Efficient delivery to human lung fibroblasts (WI-38) of pirfenidone incorporated into liposomes modified with truncated basic fibroblast growth factor and its inhibitory effect on collagen synthesis in idiopathic pulmonary fibrosis.  Biol Pharm Bull  2015  38(2):270-6  PubMed ID: 25747986
15040  Endo Y, Noguchi S, Hara Y, Hayashi YK, Motomura K, Miyatake S, Murakami N, Tanaka S, Yamashita S, Kizu R, Bamba M, Goto Y, Matsumoto N, Nonaka I, Nishino I.  Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca²⁺ channels  Hum Mol Genet  2015  24(3):637-48  PubMed ID: 25227914
10473  Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y.  The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy  PLoS One  2015  10(7):e0133713  PubMed ID: 26226340
15221  Sasaki A, Yamamoto J, Jin T, Kinjo M.  Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs  Sci Rep  2015  5:14428  PubMed ID: 26400011
15228  Narita K, Sasamoto S, Koizumi S, Okazaki S, Nakamura H, Inoue T, Takeda S.  TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport  FASEB J  2015  29(6):2247-59  PubMed ID: 25681460
15441  Tamura M, Kawano M, Sato M, Nashimoto M.  Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing  Mol Med Rep  2015  12(4):6365  PubMed ID: 26238202
12955  Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mouriño, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada  Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds  Journal of Medicinal Chemistry  2015  58:9510-9521 
6236  Xu H, Shen Z, Xiao J, Yang Y, Huang W, Zhou Z, Shen J, Zhu Y1, Liu XY, Chu L.  Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect.  BMC Cancer  2014  14:668  PubMed ID: 25220382
3443  Shimizu S, Yonezawa R, Hagiwara T, Yoshida T, Takahashi N, Hamano S, Negoro T, Toda T, Wakamori M, Mori Y, Ishii M.  Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry.  Eur J Pharmacol  2014  742:22-30  PubMed ID: 25179574
9113  Mutsuyo Takayama-Ito, Kazuo Nakamichi, Hitomi Kinoshita, Satsuki Kakiuchi, Ichiro Kurane, Masayuki Saijo, Chang-Kweng Lim  A Sensitive in Vitro Assay for the Detection of Residual Viable Rabies Virus in Inactivated Rabies Vaccines  Biologicals  2014  42 (1), 42-7  PubMed ID: 24321529
9475  Kazuhiro Shiozaki, Sena Ryuzono, Naoto Matsushita, Asami Ikeda, Kazuki Takeshita, Petros Kingstone Chigwechokha, Masaharu Komatsu, Taeko Miyagi  Molecular Cloning and Biochemical Characterization of Medaka (Oryzias Latipes) Lysosomal neu4 Sialidase  Fish Physiol Biochemc  2014  40(5):1461-72  PubMed ID: 24744226
9478  Petros Kingstone Chigwechokha, Masaharu Komatsu, Takao Itakura, Kazuhiro Shiozaki  Nile Tilapia Neu3 Sialidases: Molecular Cloning, Functional Characterization and Expression in Oreochromis Niloticus  Gene  2014  552(1):155-64  PubMed ID: 25234733
15322  Inoue M, Tanabe H, Nakashima K, Ishida Y, Kotani H.  Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene  J Nat Prod  2014  77(7):1670-7  PubMed ID: 24959987
15820  Takeuchi T, Kubo Y, Okano K, Okano T.  Identification and characterization of cryptochrome4 in the ovary of western clawed frog Xenopus tropicalis  Zoolog Sci  2014  31(3):152-9  PubMed ID: 24601777
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