CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1512 : MH7A]

21893 Ishitoku M, Mokuda S, Araki K, Watanabe H, Kohno H, Sugimoto T, Yoshida Y, Sakaguchi T, Masumoto J, Hirata S, Sugiyama E. Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation Viruses 2023 15(7):1498 PubMed ID: 37515185 DOI: 10.3390/v15071498

21894 Watanabe H, Mokuda S, Tokunaga T, Kohno H, Ishitoku M, Araki K, Sugimoto T, Yoshida Y, Yamamoto T, Matsumoto M, Masumoto J, Hirata S, Sugiyama E. Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling Inflamm Regen 2023 43(1):2 PubMed ID: 36609460 DOI: 10.1186/s41232-022-00252-4

21895 Saeki Y, Okita Y, Igashira-Oguro E, Udagawa C, Murata A, Tanaka T, Mukai J, Miyazawa K, Hoshida Y, Ohshima S. Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis Clin Rheumatol 2021 40(6):2395-2405 PubMed ID: 33415454 DOI: 10.1007/s10067-021-05579-w

7143 Imamura H, Yoshina S, Ikari K, Miyazawa K, Momohara S, Mitani S. Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line. Mod Rheumatol 2016 26:507-16 PubMed ID: 26587663 DOI: 10.3109/14397595.2015.1112481

7144 Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis. Autoimmunity 2016 49:109-14 PubMed ID: 26584911 DOI: 10.3109/08916934.2015.1113405

14142 Ferguson GD, Delgado M, Plantevin-Krenitsky V, Jensen-Pergakes K, Bates RJ, Torres S, Celeridad M, Brown H, Burnett K, Nadolny L, Tehrani L, Packard G, Pagarigan B, Haelewyn J, Nguyen T, Xu L, Tang Y, Hickman M, Baculi F, Pierce S, Miyazawa K, Jackson P, Chamberlain P, LeBrun L, Xie W, Bennett B, Blease K. A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation PLoS One 2016 11(1):e0145705 PubMed ID: 26756335 DOI: 10.1371/journal.pone.0145705

17444 Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis Autoimmunity 2015 48(4):251-8 PubMed ID: 25352179 DOI: 10.3109/08916934.2014.976631

19190 Adachi M, Okamoto S, Chujyo S, Arakawa T, Yokoyama M, Yamada K, Hayashi A, Akita K, Takeno M, Itoh S, Takii T, Waguri-Nagaya Y, Otsuka T, Hayakawa K, Miyazawa K, Onozaki K. Cigarette smoke condensate extracts induce IL-1-beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived synoviocytes, through aryl hydrocarbon receptor-dependent NF-kappa-B activation and novel NF-kappa-B sites J Interferon Cytokine Res 2013 33(6):297-307 PubMed ID: 23452206 DOI: 10.1089/jir.2012.0107

19191 Xu J, Itoh Y, Hayashi H, Takii T, Miyazawa K, Onozaki K. Dihydrotestosterone inhibits interleukin-1α or tumor necrosis factor α-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-κB activation in rheumatoid fibroblast-like synovial cell line Biol Pharm Bull 2013 34(11):1724-30. PubMed ID: 22040886 DOI: 10.1248/bpb.34.1724

7598 Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol 2012 22:228-37 PubMed ID: 22203215 DOI: 10.1007/s10165-011-0564-y

19198 Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T. Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis Mod Rheumatol 2012 22(1):128-36 PubMed ID: 21633911 DOI: 10.1007/s10165-011-0475-y

19208 Takeshita H, Kitano M, Iwasaki T, Kitano S, Tsunemi S, Sato C, Sekiguchi M, Azuma N, Miyazawa K, Hla T, Sano H. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis Biochem Biophys Res Commun 2012 419(2):154-9 PubMed ID: 22326262 DOI: 10.1016/j.bbrc.2012.01.103

19195 Sachi Tsunemi, Tsuyoshi Iwasaki, Keiji Miyazawa, Sachie Kitano, Chieri Kanda, Harunori Takeshita, Masahiro Sekiguchi, Masayasu Kitano, Hajime Sano Therapy of autoimmune diseases by novel immunosuppressant FTY720 Inflammation and Regeneration 2011 31:307-315 DOI: 10.2492/inflammregen.31.307

16998 Igarashi M, Kaga I, Takamori Y, Sakamoto K, Miyazawa K, Nagaoka I. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes Int J Mol Med 2011 27(6):821-7 PubMed ID: 21455564 DOI: 10.3892/ijmm.2011.662

16994 Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H. Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model Clin Immunol 2010 136(2):197-204 PubMed ID: 20421177 DOI: 10.1016/j.clim.2010.03.428

17991 Shibata Y, Araki H, Oshitani T, Imaoka A, Matsui M, Miyazawa K, Abiko Y. Effects of linear polarized infrared light irradiation on the transcriptional regulation of IL-8 expression in IL-1beta-stimulated human rheumatoid synoviocytes involves phosphorylation of the NF-kappaB RelA subunit J Photochem Photobiol B 2009 94(3):164-70 PubMed ID: 19135383 DOI: 10.1016/j.jphotobiol.2008.11.012

8449 Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res. Ther. 2009 11:R174 PubMed ID: 19922639 DOI: 10.1186/ar2863

19192 Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K. An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes Am J Physiol Cell Physiol 2009 297(5):C1082-90 PubMed ID: 19759329 DOI: 10.1152/ajpcell.00204.2009

19202 Su J, Yu J, Ren T, Zhang W, Zhang Y, Liu X, Sun T, Lu H, Miyazawa K, Yao L. Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis Mol Cell Biochem 2009 330(1-2):141-52 PubMed ID: 19415460 DOI: 10.1007/s11010-009-0127-0

16990 Shibata Y, Kasai H, Shimada M, Koitabashi T, Arai T, Sai R, Terao H, Horikiri M, Negishi H, Miyazawa K, Abiko Y. IL-1β stimulates IL-8 production, including prostaglandin E2 receptor EP4-triggered pathways, in synoviocyte MH7A cells Mol Med Rep 2009 ;2(3):359-63 PubMed ID: 21475837 DOI: 10.3892/mmr_00000108

19194 Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K. Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line J Interferon Cytokine Res 2008 28(8):509-21 PubMed ID: 18729741 DOI: 10.1089/jir.2007.0081

19200 Suzuki T, Tsutsumi A, Suzuki H, Suzuki E, Sugihara M, Muraki Y, Hayashi T, Chino Y, Goto D, Matsumoto I, Ito S, Miyazawa K, Sumida T. Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals Mod Rheumatol 2008 18(5):472-9 PubMed ID: 18536977 DOI: 10.1007/s10165-008-0085-5

19188 Itoh Y, Hayashi H, Miyazawa K, Kojima S, Akahoshi T, Onozaki K. 17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha J Immunol 2007 178(5):3059-66 PubMed ID: 17312152 DOI: 10.4049/jimmunol.178.5.3059

19189 Itoh Y, Hayashi H, Xu J, Takii T, Miyazawa K, Ariga H, Akahoshi T, Waguri- Nagaya Y, Otsuka T, Okamoto T, Onozaki K. Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells Biol Pharm Bull 2007 ;30(6):1140-3 PubMed ID: 17541168 DOI: 10.1248/bpb.30.1140

19212 Maeda T, Hirayama M, Kobayashi D, Miyazawa K, Tamai I. Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines Drug Metab Dispos 2007 ;35(3):394-401 PubMed ID: 17142562 DOI: 10.1124/dmd.106.012112

18877 Heum Park J, Cho Han D, Kim J, Hyung Hong S, Lee SK, Seog Yoon K, Min Kim J, Son KH, Miyazawa K, Kwon BM. Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen Life Sci 2006 78(19):2204-12 PubMed ID: 16289138 DOI: 10.1016/j.lfs.2005.09.029

19196 Yoo SA, Park BH, Park GS, Koh HS, Lee MS, Ryu SH, Miyazawa K, Park SH, Cho CS, Kim WU. Calcineurin is expressed and plays a critical role in inflammatory arthritis J Immunol 2006 177(4):2681-90 PubMed ID: 16888030 DOI: 10.4049/jimmunol.177.4.2681

19213 Kim SJ, Shin HH, Park SY, Lee DS, Lee EA, Cho SD, Cho HR, Miyazawa K, Choi HS. Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells Osteoarthritis Cartilage 2006 14(2):146-53 PubMed ID: 16242974 DOI: 10.1016/j.joca.2005.08.012

10354 Masaji Morita 1, Yoshiko Banno, Taikoh Dohjima, Satoshi Nozawa, Kazunari Fushimi, De-Gang Fan, Takatoshi Ohno, Keiji Miyazawa, Naxin Liu, Katsuji Shimizu Mu-calpain Is Involved in the Regulation of TNF-alpha-induced Matrix metalloproteinase-3 Release in a Rheumatoid Synovial Cell Line Biochem Biophys Res Commun 2006 343(3):937-42 PubMed ID: 16574073 DOI: 10.1016/j.bbrc.2006.02.155

16988 Han SK, Jeon SJ, Miyazawa K, Yi SY, Yoo YS. Enhancement of anti-inflammatory tendency by SB203580, p38alpha specific inhibitor, in human fibroblast-like synoviocyte cell line, MH7A Rheumatol Int 2006 26(11):972-8 PubMed ID: 16532349 DOI: 10.1007/s00296-006-0109-4

16992 Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression Arthritis Rheum 2006 54(3):742-53 PubMed ID: 16508938 DOI: 10.1002/art.21668

19197 Shibata Y, Ogura N, Yamashiro K, Takashiba S, Kondoh T, Miyazawa K, Matsui M, Abiko Y. Anti-inflammatory effect of linear polarized infrared irradiation on interleukin-1beta-induced chemokine production in MH7A rheumatoid synovial cells Lasers Med Sci 2005 20(3-4):109-13 PubMed ID: 16047084 DOI: 10.1007/s10103-005-0350-1

19193 Tamaki A, Hayashi H, Nakajima H, Takii T, Katagiri D, Miyazawa K, Hirose K, Onozaki K. Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor Biol Pharm Bull 2004 ;27(3):407-10 PubMed ID: 14993811 DOI: 10.1248/bpb.27.407

2339 Miyazawa K, Mori A, Yamamoto K, Okudaira H Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes. J Biol Chem 1998 273:7620-7 PubMed ID: 9516466 DOI: 10.1074/jbc.273.13.7620

2338 Miyazawa K, Mori A, Okudaira H Establishment and Characterization of a Novel Human Rheumatoid Fibroblast-Like Synoviocyte Line, MH7A, Immortalized with SV40 T Antigen J Biochem 1998 124:1153-1162 PubMed ID: 9832620 DOI: 10.1093/oxfordjournals.jbchem.a022233

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21705 Fujii K, Iwata I, Takaya A, Ishibashi M, Hara Y. New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells. J Nat Med 2024 PubMed ID: 38592349 DOI: 10.1007/s11418-024-01801-6

21723 Zihe Ding, Xiaoyue Wang, Yi Zhang, Jian Liu, Lei Wan, Tao Li, Lin Chen, Na Lin, Yanqiong Zhang Altered Iron-Mediated Metabolic Homeostasis Governs the Efficacy and Toxicity of Tripterygium Glycosides Tablets Against Rheumatoid Arthritis Engineering 2024 DOI: 10.1016/j.eng.2024.04.003

21724 Lin CY, Lee KT, Lin YY, Tsai CH, Ko CY, Fong YC, Hou SM, Chen WL, Huang CC, Tang CH. NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis Int Immunopharmacol 2024 130:111733 PubMed ID: 38387191 DOI: 10.1016/j.intimp.2024.111733

21725 Achudhan D, Lai YL, Lin YY, Huang YL, Tsai CH, Ho TL, Ko CY, Fong YC, Huang CC, Tang CH. CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation Biochem Pharmacol 2024 Mar:221:116037 PubMed ID: 38301965 DOI: 10.1016/j.bcp.2024.116037

21744 Lin L, Huang Z, Li W, Liu X, Li X, Gao S, Chen J, Yang C, Min X, Yang H, Gong Q, Wei Y, Tu S, Rao X, Zhang Z, Dong L, Zhong J. Mid1 Promotes Synovitis in Rheumatoid Arthritis via Ubiquitin-dependent Post-translational Modification. Pharmacol Res 2024 107224 PubMed ID: 38777113 DOI: 10.1016/j.phrs.2024.107224

21890 Tsuchiya H, Ota M, Takahashi H, Hatano H, Ogawa M, Nakajima S, Yoshihara R, Okamura T, Sumitomo S, Fujio K. Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis Inflamm Regen 2024 44(1):29 PubMed ID: 38831367 DOI: 10.1186/s41232-024-00337-2

21891 Mao L, Liu L, Li J, Yang X, Xu X, Liu M, Zhang Y, Wei W, Chen J. Ginsenoside compound K plays an anti-inflammatory effect without inducing glucose metabolism disorder in adjuvant-induced arthritis rats Food Funct 2024 15(12):6475-6487 PubMed ID: 38804652 DOI: 10.1039/d4fo01460j

21892 Hu SL, Thadevoos LA, Ho TL, Lin YY, Chen HT, Huang CC, Su CM, Tang CH. FGF23 facilitates IL-1β synthesis in rheumatoid arthritis through activating PI3K, Akt, and NF-κB pathways Environ Toxicol 2024 39(6):3283-3291 PubMed ID: 38380842 DOI: 10.1002/tox.24180

21931 Kuo CL, Hsin-Hsien Yeh S, Chang TM, I-Chin Wei A, Chen WJ, Chu HF, Tseng AL, Lin PL, Lin ZC, Peng KT, Liu JF. Bacillus coagulans BACO-17 ameliorates in vitro and in vivo progression of Rheumatoid arthritis. Int Immunopharmacol 2024 141:112863 PubMed ID: 39146779 DOI: 10.1016/j.intimp.2024.112863

21973 Wu H, Yuan H, Zhang J, He T, Deng Y, Chen Y, Zhang Y, Chen W, Wu C. Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1α to exacerbate rheumatoid arthritis Ann Rheum Dis 2024 Aug 6:ard-2023-225306 PubMed ID: 39107082 DOI: 10.1136/ard-2023-225306

22057 Wang H, Tian X, Ji L, Shi L, Wang Y. RNA-seq Based Transcriptome Analysis Reveals Role of Myoglobin in Rheumatoid Arthritis. Inflammation 2024 PubMed ID: 39379676 DOI: 10.1007/s10753-024-02151-x

22070 Chen W, Lee GE, Jeung D, Byun J, Wu J, Li X, Lee JY, Kang HC, Lee HS, Kim KD, Nam SB, Lee CJ, Kwon YJ, Cho YY. RSK2-mediated cGAS phosphorylation induces cGAS chromatin-incorporation-mediated cell transformation and cancer cell colony growth. Cell Death Discov 2024 10(1):442 PubMed ID: 39424777 DOI: 10.1038/s41420-024-02208-8

22157 Tsai SW, Cheng YC, Chao YH, Yang DH. Sinulariolide Suppresses Inflammation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis and Mitigates Collagen-Induced Arthritis Symptoms in Mice. J Inflamm Res 2024 17:8299-8311 PubMed ID: 39525321 DOI: 10.2147/JIR.S476847

17608 Ni R, Liu H, Song G, Fu X, Deng B, Xu Z, Dai S, Huang G. MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5 Int J Rheum Dis 2023 26(4):699-709 PubMed ID: 36843205 DOI: 10.1111/1756-185X.14622

17771 Liu F, Zhan S, Zhang P, Jia C, Zhu Q, Dai Q, Yu M, Cheng L, Xiong L, Sun F, Xia P, Zhang X, Hu J. Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula Front Physiol 2023 14:1138947 PubMed ID: 36969583 DOI: 10.3389/fphys.2023.1138947

19563 Chang JW, Liu SC, Lin YY, He XY, Wu YS, Su CM, Tsai CH, Chen HT, Fong YC, Hu SL, Huang CC, Tang CH. Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy Int J Biol Sci 2023 19(1):281-293 PubMed ID: 36594093 DOI: 10.7150/ijbs.77987

21328 Chang JW, Lin YY, Tsai CH, Liu SC, He XY, Wu YS, Huang CC, Tang CH. Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis. Biochem Pharmacol 2023 115687 PubMed ID: 37481139 DOI: 10.1016/j.bcp.2023.115687

21495 Mao X, Yan X, Li C, Liu Y, Zhang Y, Lin N. Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis. Chin Med 2023 18(1):156 PubMed ID: 38037139 DOI: 10.1186/s13020-023-00863-0

21519 Jiang Y, Zhong S, Tan H, Fu Y, Lai J, Liu L, Weng J, Chen H, He S. Study on the mechanism of action of Saposhnikovia divaricata and its key phytochemical on rheumatoid arthritis based on network pharmacology and bioinformatics. J Ethnopharmacol 2023 117586 PubMed ID: 38104871 DOI: 10.1016/j.jep.2023.117586

17636 Mokuda S, Watanabe H, Kohno H, Ishitoku M, Araki K, Hirata S, Sugiyama E. N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes Cytotechnology 2022 74(4):503-514 PubMed ID: 35791402 DOI: 10.1007/s10616-022-00540-4

20557 Lin X, Tao C, Zhang R, Zhang M, Wang Q, Chen J. N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes. Phytomedicine 2022 95:153871 PubMed ID: 34902811 DOI: 10.1016/j.phymed.2021.153871

20626 Li L, Zhan M, Li M. Circular RNA circ_0130438 suppresses TNF-α-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis. Transpl Immunol 2022 101588 PubMed ID: 35358709 DOI: 10.1016/j.trim.2022.101588

16620 David Achudhan, Sunny Li-Yun Chang, Shan-Chi Liu, Yen-You Lin, Wei-Chien Huang, Yang-Chang Wu, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, Yueh-Hsiung Kuo, Chih-Hsin Tang Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts Food & Nutrition Research 2022 66 PubMed ID: 35783555 DOI: 10.29219/fnr.v66.8645

16745 Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q, Su X, Yan S, Su W, Zhang Y, Lin N. A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis Front Immunol 2022 13:912933 PubMed ID: 35799788 DOI: 10.3389/fimmu.2022.912933

16922 Fu M, Sang X, Cheng H. Total glucosides of peony induce fibroblast-like synovial apoptosis, and ameliorate cartilage injury via blocking the NF-κB/STAT3 pathway Ann Transl Med 2022 10(2):51 PubMed ID: 35282135 DOI: 10.21037/atm-21-6187

16987 Konishi H, Kanou SE, Yukimatsu R, Inui M, Sato M, Yamamoto N, Nakano M, Koshiba M. Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A 2A receptor signaling Sci Rep 2022 12(1):6033 PubMed ID: 35410356 DOI: 10.1038/s41598-022-10012-6

16999 Sueda Y, Okazaki R, Funaki Y, Hasegawa Y, Ishikawa H, Hirayama Y, Inui G, Harada T, Takata M, Morita M, Yamasaki A. Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts Yonago Acta Med 2022 65(2):111-125 PubMed ID: 35611061 DOI: 10.33160/yam.2022.05.001

17000 Sun X, Li KX, Figueiredo ML, Lin CC, Li BY, Yokota H. Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling Cancers (Basel) 2022 14(13):3039 PubMed ID: 35804814 DOI: 10.3390/cancers14133039

20977 Yu B, Chen Y, Chen E, Zuo F, Yuan Y, Zhao X, Xiao C. LncRNA RNA XIST binding to GATA1 contributes to rheumatoid arthritis through its effects on proliferation of synovial fibroblasts and angiogenesis via regulation of CCN6. Mol Immunol 2022 153:200-211 PubMed ID: 36542956 DOI: 10.1016/j.molimm.2022.12.004

21031 Xu L, Niu X, Liu Y, Liu L. ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway. Mediators Inflamm 2022 2022:4258742 PubMed ID: 36405992 DOI: 10.1155/2022/4258742

21659 Achudhan D, Liu SC, Lin YY, Lee HP, Wang SW, Huang WC, Wu YC, Kuo YH, Tang CH. Antcin K inhibits VEGF-dependent angiogenesis in human rheumatoid arthritis synovial fibroblasts J Food Biochem 2022 46(1):e14022 PubMed ID: 34841538 DOI: 10.1111/jfbc.14022

13169 Fu X, Song G, Ni R, Liu H, Xu Z, Zhang D, He F, Huang G. LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a. Rheumatology (Oxford) 2021 PubMed ID: 32810279 DOI: 10.1093/rheumatology/keaa395

14180 Gan D, Cheng W, Ke L, Sun AR, Jia Q, Chen J, Lin J, Li J, Xu Z, Zhang P. Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis Front Pharmacol 2021 12:631891 PubMed ID: 33746759 DOI: 10.3389/fphar.2021.631891

14833 Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N. Metformin repositioning in rheumatoid arthritis Clin Exp Rheumatol 2021 39(4):763-768 PubMed ID: 32828146 DOI: 10.55563/clinexprheumatol/zn2u9h

20292 Chen J, Li J, Chen J, Cheng W, Lin J, Ke L, Liu G, Bai X, Zhang P. Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor. J Orthop Translat 2021 28:100-107 PubMed ID: 33816113 DOI: 10.1016/j.jot.2021.01.003

20295 Kaihara K, Nakagawa S, Arai Y, Inoue H, Tsuchida S, Fujii Y, Kamada Y, Kishida T, Mazda O, Takahashi K. Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α. Int J Mol Sci 2021 22(8) PubMed ID: 33918929 DOI: 10.3390/ijms22083898

15287 Yoon SS, Moon EY. B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor Int J Mol Sci 2021 22(13):7166 PubMed ID: 34281218 DOI: 10.3390/ijms22137166

15291 Matsumoto M, Liu J, Iwata K, Ibi M, Asaoka N, Zhang X, Katsuyama M, Matsuda M, Nabe T, Schröder K, Yabe-Nishimura C. NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis J Pharmacol Sci 2021 146(2):88-97 PubMed ID: 33941325 DOI: 10.1016/j.jphs.2021.01.009

20446 Mijiti N, Someya A, Nagaoka I. Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells. Exp Ther Med 2021 22(5):1300 PubMed ID: 34630655 DOI: 10.3892/etm.2021.10735

16272 Li C, Pan J, Xu C, Jin Z, Chen X. A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking Front Cell Dev Biol 2021 9:740266 PubMed ID: 35127697 DOI: 10.3389/fcell.2021.740266

16277 Chang TK, Zhong YH, Liu SC, Huang CC, Tsai CH, Lee HP, Wang SW, Hsu CJ, Tang CH. Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway Front Immunol 2021 12:737990 PubMed ID: 34659230 DOI: 10.3389/fimmu.2021.737990

16278 Achudhan D, Liu SC, Lin YY, Huang CC, Tsai CH, Ko CY, Chiang IP, Kuo YH, Tang CH. Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis Front Immunol 2021 12:790925 PubMed ID: 34975889 DOI: 10.3389/fimmu.2021.790925

16929 Lin J, Sun AR, Li J, Yuan T, Cheng W, Ke L, Chen J, Sun W, Mi S, Zhang P. A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue Front Bioeng Biotechnol 2021 9:764212 PubMed ID: 34869276 DOI: 10.3389/fbioe.2021.764212

16980 Chen X, Lin H, Chen J, Wu L, Zhu J, Ye Y, Chen S, Du H, Li J. Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis Front Pharmacol 2021 12:714566 PubMed ID: 34566640 DOI: 10.3389/fphar.2021.714566

16983 Law YY, Lee WF, Hsu CJ, Lin YY, Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF. miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts Aging (Albany NY) 2021 13(13):17227-17236 PubMed ID: 34198264 DOI: 10.18632/aging.203201

16991 Ba X, Huang Y, Shen P, Huang Y, Wang H, Han L, Lin WJ, Yan HJ, Xu LJ, Qin K, Chen Z, Tu SH. WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway Front Pharmacol 2021 12:696802 PubMed ID: 34646130 DOI: 10.3389/fphar.2021.696802

16995 Huang CC, Law YY, Liu SC, Hu SL, Lin JA, Chen CJ, Wang SW, Tang CH. Adiponectin Promotes VEGF Expression in Rheumatoid Arthritis Synovial Fibroblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-106a-5p Cells 2021 10(10):2627 PubMed ID: 34685605 DOI: 10.3390/cells10102627

17083 Han CK, Lee WF, Hsu CJ, Huang YL, Lin CY, Tsai CH, Huang CC, Fong YC, Wu MH, Liu JF, Tang CH. DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts J Cell Physiol 2021 236(12):8060-8069 PubMed ID: 34192347 DOI: 10.1002/jcp.30494

13031 Yamagishi Y, Someya A, Nagaoka I. Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine. Biomed Rep 2020 PubMed ID: 32440348 DOI: 10.3892/br.2020.1304

13058 Tsai MH, Chi MC, Hsu JF, Lee IT, Lin KM, Fang ML, Lee MH, Lee CW, Liu JF. Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis. Cells 2020 PubMed ID: 32498294 DOI: 10.3390/cells9061378

13149 Lee J, Yoon SS, Thuy PX, Moon EY. Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426. Biomol Ther (Seoul) 2020 PubMed ID: 32753567 DOI: 10.4062/biomolther.2020.110

13503 Wu H, He Y, Wu H, Zhou M, Xu Z, Xiong R, Yan F, Liu H. Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes Theranostics 2020 10(22):10092-10105 PubMed ID: 32929336 DOI: 10.7150/thno.44865

13519 Wu S, Wang J, Li J, Li F. microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5 Inflammation 2020 43(2):441-454 PubMed ID: 32008163 DOI: 10.1007/s10753-019-01117-8

13540 Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS. PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis Biomol Ther (Seoul) 2020 28(2):172-183 PubMed ID: 31739383 DOI: 10.4062/biomolther.2019.153

13563 Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q. Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model Front Pharmacol 2020 11:45 PubMed ID: 32116720 DOI: 10.3389/fphar.2020.00045

13644 Hsiang-Ping Lee, Yang-Chang Wu, Bo-Cheng Chen, Shan-Chi Liu, Te-Mao Li, Wei-Chien Huang, Chin-Jung Hsu, Chih-Hsin Tang Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways Food and Agricultural Immunology 2020 21(740-750) DOI: 10.1080/09540105.2020.1766426

13645 Kanai T, Kondo N, Okada M, Sano H, Okumura G, Kijima Y, Ogose A, Kawashima H, Endo N. The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3 J Orthop Surg Res 2020 15(1):87 PubMed ID: 32131874 DOI: 10.1186/s13018-020-01595-9

14843 Cheng WX, Zhong S, Meng XB, Zheng NY, Zhang P, Wang Y, Qin L, Wang XL Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats J Pharmacol Exp Ther 2020 373(2):302-310 PubMed ID: 32029577 DOI: 10.1124/jpet.119.262907

14856 Liu C, He L, Wang J, Wang Q, Sun C, Li Y, Jia K, Wang J, Xu T, Ming R, Wang Q, Lin N. Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways J Ethnopharmacol 2020 260:113039 PubMed ID: 32497675 DOI: 10.1016/j.jep.2020.113039

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17001 Zhang Y, Wang X, Li W, Wang H, Yin X, Jiang F, Su X, Chen W, Li T, Mao X, Guo M, Jiang Q, Lin N. Inferences of individual differences in response to tripterysium glycosides across patients with Rheumatoid arthritis using a novel ceRNA regulatory axis Clin Transl Med 2020 10(6):e185 PubMed ID: 33135351 DOI: 10.1002/ctm2.185

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11688 Wen-Xiang Cheng, Huan Huang, Jian-Hai Chen, Tian-Tian Zhang, Guo-Yuan Zhu, Zheng-Tan Zheng, Jie-Tao Lin, Yi-Ping Hu, Yong Zhang, Xue-Ling Bai, Yan Wang, Zhan-Wang Xu, Bing Song, Yi-Ying Mao, Fei Yang, Peng Zhang Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway Journal of Orthopaedic Translation 2019 PubMed ID: 32440504 DOI: 10.1016/j.jot.2019.07.007

12330 Jia Q, Wang T, Wang X, Xu H, Liu Y, Wang Y, Shi Q, Liang Q. Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes Front Pharmacol 2019 10:94 PubMed ID: 30809149 DOI: 10.3389/fphar.2019.00094

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10932 Shupeng WU, Jing WANG, Fang LI Role of SNF5 in rheumatoid arthritis by up-regulation of p16 and inactivation of JNK 1 pathway Turkish Journal of Biology 2017 41: 535-542 DOI: 10.3906/biy-1610-40

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14451 Hu SL, Chang AC, Huang CC, Tsai CH, Lin CC, Tang CH. Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p Front Immunol 2017 8:1747 PubMed ID: 29276516 DOI: 10.3389/fimmu.2017.01747

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14590 Tang Q, Cui J, Tian Z, Sun J, Wang Z, Chang S, Zhu S. Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes Int J Nanomedicine 2017 12:381-393 PubMed ID: 28123298 DOI: 10.2147/IJN.S120902

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