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Cell No. : Cell Name
RCB1512 : MH7A  update : 2024/08/05
CommentRheumatoid fibroblast-like synoviocyte transformed with SV40 T antigen. Respond to IL-1beta.
Comment from the depositor
Terms and conditions In relation to all kinds of use, it is necessary to pay license fee to the depositor. First of all, please contact the depositor.
Remarks
approver's address
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English
Address
Kissei Pharmaceutical Co., Ltd.

4365-1 Kashihara, Hodaka, Azumino, Nagano 399-8304 Japan
Dr.R & D, Planning
Fax. +81-263-82-8826
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information IPR Kissei Pharmaceutical Co., Ltd.
Depositor R & D, Planning
Originator Miyazawa, Keiji
Year of deposit 1999
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 53 years
Tissue synovial
Disease name Rheumatoid Arthritis (RA)
Classification transformed
Recombinant recombinant
Exogene SV40 large T antigen
Lifespan infinite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_0427
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Isozyme LD, NP
Chromosome mode 66-82(50) : /73(6),74(4),75(6),76(3),77(7),78(5)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 35
User's Publication 134


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Reference
21893  Ishitoku M, Mokuda S, Araki K, Watanabe H, Kohno H, Sugimoto T, Yoshida Y, Sakaguchi T, Masumoto J, Hirata S, Sugiyama E.   Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation  Viruses  2023  15(7):1498  PubMed ID: 37515185   DOI: 10.3390/v15071498
21894  Watanabe H, Mokuda S, Tokunaga T, Kohno H, Ishitoku M, Araki K, Sugimoto T, Yoshida Y, Yamamoto T, Matsumoto M, Masumoto J, Hirata S, Sugiyama E.  Expression of factor XIII originating from synovial fibroblasts and macrophages induced by interleukin-6 signaling  Inflamm Regen  2023  43(1):2  PubMed ID: 36609460   DOI: 10.1186/s41232-022-00252-4
21895  Saeki Y, Okita Y, Igashira-Oguro E, Udagawa C, Murata A, Tanaka T, Mukai J, Miyazawa K, Hoshida Y, Ohshima S.  Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis  Clin Rheumatol  2021  40(6):2395-2405  PubMed ID: 33415454   DOI: 10.1007/s10067-021-05579-w
7143  Imamura H, Yoshina S, Ikari K, Miyazawa K, Momohara S, Mitani S.  Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.  Mod Rheumatol  2016  26:507-16  PubMed ID: 26587663   DOI: 10.3109/14397595.2015.1112481
7144  Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.  Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis.  Autoimmunity  2016  49:109-14  PubMed ID: 26584911   DOI: 10.3109/08916934.2015.1113405
14142  Ferguson GD, Delgado M, Plantevin-Krenitsky V, Jensen-Pergakes K, Bates RJ, Torres S, Celeridad M, Brown H, Burnett K, Nadolny L, Tehrani L, Packard G, Pagarigan B, Haelewyn J, Nguyen T, Xu L, Tang Y, Hickman M, Baculi F, Pierce S, Miyazawa K, Jackson P, Chamberlain P, LeBrun L, Xie W, Bennett B, Blease K.  A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation  PLoS One  2016  11(1):e0145705  PubMed ID: 26756335   DOI: 10.1371/journal.pone.0145705
17444  Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.  Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis  Autoimmunity  2015  48(4):251-8  PubMed ID: 25352179   DOI: 10.3109/08916934.2014.976631
19190  Adachi M, Okamoto S, Chujyo S, Arakawa T, Yokoyama M, Yamada K, Hayashi A, Akita K, Takeno M, Itoh S, Takii T, Waguri-Nagaya Y, Otsuka T, Hayakawa K, Miyazawa K, Onozaki K.   Cigarette smoke condensate extracts induce IL-1-beta production from rheumatoid arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived synoviocytes, through aryl hydrocarbon receptor-dependent NF-kappa-B activation and novel NF-kappa-B sites  J Interferon Cytokine Res  2013  33(6):297-307  PubMed ID: 23452206   DOI: 10.1089/jir.2012.0107
19191  Xu J, Itoh Y, Hayashi H, Takii T, Miyazawa K, Onozaki K.   Dihydrotestosterone inhibits interleukin-1α or tumor necrosis factor α-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-κB activation in rheumatoid fibroblast-like synovial cell line  Biol Pharm Bull  2013  34(11):1724-30.  PubMed ID: 22040886   DOI: 10.1248/bpb.34.1724
7598  Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I.  Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis.  Mod Rheumatol  2012  22:228-37  PubMed ID: 22203215   DOI: 10.1007/s10165-011-0564-y
19198  Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T.  Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis  Mod Rheumatol  2012  22(1):128-36  PubMed ID: 21633911   DOI: 10.1007/s10165-011-0475-y
19208  Takeshita H, Kitano M, Iwasaki T, Kitano S, Tsunemi S, Sato C, Sekiguchi M, Azuma N, Miyazawa K, Hla T, Sano H.  Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis  Biochem Biophys Res Commun  2012  419(2):154-9  PubMed ID: 22326262   DOI: 10.1016/j.bbrc.2012.01.103
19195  Sachi Tsunemi, Tsuyoshi Iwasaki, Keiji Miyazawa, Sachie Kitano, Chieri Kanda, Harunori Takeshita, Masahiro Sekiguchi, Masayasu Kitano, Hajime Sano  Therapy of autoimmune diseases by novel immunosuppressant FTY720  Inflammation and Regeneration  2011  31:307-315    DOI: 10.2492/inflammregen.31.307
16998  Igarashi M, Kaga I, Takamori Y, Sakamoto K, Miyazawa K, Nagaoka I.  Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes  Int J Mol Med  2011  27(6):821-7  PubMed ID: 21455564   DOI: 10.3892/ijmm.2011.662
16994  Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H.  Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model  Clin Immunol  2010  136(2):197-204  PubMed ID: 20421177   DOI: 10.1016/j.clim.2010.03.428
17991  Shibata Y, Araki H, Oshitani T, Imaoka A, Matsui M, Miyazawa K, Abiko Y.  Effects of linear polarized infrared light irradiation on the transcriptional regulation of IL-8 expression in IL-1beta-stimulated human rheumatoid synoviocytes involves phosphorylation of the NF-kappaB RelA subunit  J Photochem Photobiol B  2009  94(3):164-70  PubMed ID: 19135383   DOI: 10.1016/j.jphotobiol.2008.11.012
8449  Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.  Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis.  Arthritis Res. Ther.  2009  11:R174  PubMed ID: 19922639   DOI: 10.1186/ar2863
19192  Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.  An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes  Am J Physiol Cell Physiol  2009  297(5):C1082-90  PubMed ID: 19759329   DOI: 10.1152/ajpcell.00204.2009
19202  Su J, Yu J, Ren T, Zhang W, Zhang Y, Liu X, Sun T, Lu H, Miyazawa K, Yao L.  Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis  Mol Cell Biochem  2009  330(1-2):141-52  PubMed ID: 19415460   DOI: 10.1007/s11010-009-0127-0
16990  Shibata Y, Kasai H, Shimada M, Koitabashi T, Arai T, Sai R, Terao H, Horikiri M, Negishi H, Miyazawa K, Abiko Y.  IL-1β stimulates IL-8 production, including prostaglandin E2 receptor EP4-triggered pathways, in synoviocyte MH7A cells  Mol Med Rep  2009  ;2(3):359-63  PubMed ID: 21475837   DOI: 10.3892/mmr_00000108
19194  Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.   Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line  J Interferon Cytokine Res  2008  28(8):509-21  PubMed ID: 18729741   DOI: 10.1089/jir.2007.0081
19200  Suzuki T, Tsutsumi A, Suzuki H, Suzuki E, Sugihara M, Muraki Y, Hayashi T, Chino Y, Goto D, Matsumoto I, Ito S, Miyazawa K, Sumida T.  Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals  Mod Rheumatol  2008  18(5):472-9  PubMed ID: 18536977   DOI: 10.1007/s10165-008-0085-5
19188  Itoh Y, Hayashi H, Miyazawa K, Kojima S, Akahoshi T, Onozaki K.  17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha  J Immunol  2007  178(5):3059-66  PubMed ID: 17312152   DOI: 10.4049/jimmunol.178.5.3059
19189  Itoh Y, Hayashi H, Xu J, Takii T, Miyazawa K, Ariga H, Akahoshi T, Waguri- Nagaya Y, Otsuka T, Okamoto T, Onozaki K.  Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells  Biol Pharm Bull  2007  ;30(6):1140-3  PubMed ID: 17541168   DOI: 10.1248/bpb.30.1140
19212  Maeda T, Hirayama M, Kobayashi D, Miyazawa K, Tamai I.  Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines  Drug Metab Dispos  2007  ;35(3):394-401  PubMed ID: 17142562   DOI: 10.1124/dmd.106.012112
18877  Heum Park J, Cho Han D, Kim J, Hyung Hong S, Lee SK, Seog Yoon K, Min Kim J, Son KH, Miyazawa K, Kwon BM.  Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen  Life Sci  2006  78(19):2204-12  PubMed ID: 16289138   DOI: 10.1016/j.lfs.2005.09.029
19196  Yoo SA, Park BH, Park GS, Koh HS, Lee MS, Ryu SH, Miyazawa K, Park SH, Cho CS, Kim WU.   Calcineurin is expressed and plays a critical role in inflammatory arthritis  J Immunol  2006  177(4):2681-90  PubMed ID: 16888030   DOI: 10.4049/jimmunol.177.4.2681
19213  Kim SJ, Shin HH, Park SY, Lee DS, Lee EA, Cho SD, Cho HR, Miyazawa K, Choi HS.  Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells  Osteoarthritis Cartilage  2006  14(2):146-53  PubMed ID: 16242974   DOI: 10.1016/j.joca.2005.08.012
10354  Masaji Morita 1, Yoshiko Banno, Taikoh Dohjima, Satoshi Nozawa, Kazunari Fushimi, De-Gang Fan, Takatoshi Ohno, Keiji Miyazawa, Naxin Liu, Katsuji Shimizu  Mu-calpain Is Involved in the Regulation of TNF-alpha-induced Matrix metalloproteinase-3 Release in a Rheumatoid Synovial Cell Line  Biochem Biophys Res Commun  2006  343(3):937-42  PubMed ID: 16574073   DOI: 10.1016/j.bbrc.2006.02.155
16988  Han SK, Jeon SJ, Miyazawa K, Yi SY, Yoo YS.  Enhancement of anti-inflammatory tendency by SB203580, p38alpha specific inhibitor, in human fibroblast-like synoviocyte cell line, MH7A  Rheumatol Int  2006  26(11):972-8  PubMed ID: 16532349   DOI: 10.1007/s00296-006-0109-4
16992  Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY.  Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression  Arthritis Rheum  2006  54(3):742-53  PubMed ID: 16508938   DOI: 10.1002/art.21668
19197  Shibata Y, Ogura N, Yamashiro K, Takashiba S, Kondoh T, Miyazawa K, Matsui M, Abiko Y.  Anti-inflammatory effect of linear polarized infrared irradiation on interleukin-1beta-induced chemokine production in MH7A rheumatoid synovial cells  Lasers Med Sci  2005  20(3-4):109-13  PubMed ID: 16047084   DOI: 10.1007/s10103-005-0350-1
19193  Tamaki A, Hayashi H, Nakajima H, Takii T, Katagiri D, Miyazawa K, Hirose K, Onozaki K.  Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor  Biol Pharm Bull  2004  ;27(3):407-10  PubMed ID: 14993811   DOI: 10.1248/bpb.27.407
2339  Miyazawa K, Mori A, Yamamoto K, Okudaira H  Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes.  J Biol Chem  1998  273:7620-7  PubMed ID: 9516466   DOI: 10.1074/jbc.273.13.7620
2338  Miyazawa K, Mori A, Okudaira H  Establishment and Characterization of a Novel Human Rheumatoid Fibroblast-Like Synoviocyte Line, MH7A, Immortalized with SV40 T Antigen  J Biochem  1998  124:1153-1162  PubMed ID: 9832620   DOI: 10.1093/oxfordjournals.jbchem.a022233

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User's Publication
21705  Fujii K, Iwata I, Takaya A, Ishibashi M, Hara Y.  New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells.  J Nat Med  2024    PubMed ID: 38592349   DOI: 10.1007/s11418-024-01801-6
21723  Zihe Ding, Xiaoyue Wang, Yi Zhang, Jian Liu, Lei Wan, Tao Li, Lin Chen, Na Lin, Yanqiong Zhang  Altered Iron-Mediated Metabolic Homeostasis Governs the Efficacy and Toxicity of Tripterygium Glycosides Tablets Against Rheumatoid Arthritis  Engineering  2024      DOI: 10.1016/j.eng.2024.04.003
21724  Lin CY, Lee KT, Lin YY, Tsai CH, Ko CY, Fong YC, Hou SM, Chen WL, Huang CC, Tang CH.  NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis  Int Immunopharmacol  2024  130:111733  PubMed ID: 38387191   DOI: 10.1016/j.intimp.2024.111733
21725  Achudhan D, Lai YL, Lin YY, Huang YL, Tsai CH, Ho TL, Ko CY, Fong YC, Huang CC, Tang CH.  CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation  Biochem Pharmacol  2024  Mar:221:116037  PubMed ID: 38301965   DOI: 10.1016/j.bcp.2024.116037
21744  Lin L, Huang Z, Li W, Liu X, Li X, Gao S, Chen J, Yang C, Min X, Yang H, Gong Q, Wei Y, Tu S, Rao X, Zhang Z, Dong L, Zhong J.  Mid1 Promotes Synovitis in Rheumatoid Arthritis via Ubiquitin-dependent Post-translational Modification.  Pharmacol Res  2024  107224  PubMed ID: 38777113   DOI: 10.1016/j.phrs.2024.107224
21890  Tsuchiya H, Ota M, Takahashi H, Hatano H, Ogawa M, Nakajima S, Yoshihara R, Okamura T, Sumitomo S, Fujio K.  Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis  Inflamm Regen  2024  44(1):29  PubMed ID: 38831367   DOI: 10.1186/s41232-024-00337-2
21891  Mao L, Liu L, Li J, Yang X, Xu X, Liu M, Zhang Y, Wei W, Chen J.  Ginsenoside compound K plays an anti-inflammatory effect without inducing glucose metabolism disorder in adjuvant-induced arthritis rats  Food Funct  2024  15(12):6475-6487  PubMed ID: 38804652   DOI: 10.1039/d4fo01460j
21892  Hu SL, Thadevoos LA, Ho TL, Lin YY, Chen HT, Huang CC, Su CM, Tang CH.  FGF23 facilitates IL-1β synthesis in rheumatoid arthritis through activating PI3K, Akt, and NF-κB pathways  Environ Toxicol  2024  39(6):3283-3291  PubMed ID: 38380842   DOI: 10.1002/tox.24180
21931  Kuo CL, Hsin-Hsien Yeh S, Chang TM, I-Chin Wei A, Chen WJ, Chu HF, Tseng AL, Lin PL, Lin ZC, Peng KT, Liu JF.  Bacillus coagulans BACO-17 ameliorates in vitro and in vivo progression of Rheumatoid arthritis.  Int Immunopharmacol  2024  141:112863  PubMed ID: 39146779   DOI: 10.1016/j.intimp.2024.112863
21973  Wu H, Yuan H, Zhang J, He T, Deng Y, Chen Y, Zhang Y, Chen W, Wu C.  Helicobacter pylori upregulates PAD4 expression via stabilising HIF-1α to exacerbate rheumatoid arthritis  Ann Rheum Dis  2024  Aug 6:ard-2023-225306  PubMed ID: 39107082   DOI: 10.1136/ard-2023-225306
22057  Wang H, Tian X, Ji L, Shi L, Wang Y.  RNA-seq Based Transcriptome Analysis Reveals Role of Myoglobin in Rheumatoid Arthritis.  Inflammation  2024    PubMed ID: 39379676   DOI: 10.1007/s10753-024-02151-x
17608  Ni R, Liu H, Song G, Fu X, Deng B, Xu Z, Dai S, Huang G.  MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5  Int J Rheum Dis  2023  26(4):699-709  PubMed ID: 36843205   DOI: 10.1111/1756-185X.14622
17771  Liu F, Zhan S, Zhang P, Jia C, Zhu Q, Dai Q, Yu M, Cheng L, Xiong L, Sun F, Xia P, Zhang X, Hu J.  Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula  Front Physiol  2023  14:1138947  PubMed ID: 36969583   DOI: 10.3389/fphys.2023.1138947
19563  Chang JW, Liu SC, Lin YY, He XY, Wu YS, Su CM, Tsai CH, Chen HT, Fong YC, Hu SL, Huang CC, Tang CH.  Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy  Int J Biol Sci  2023  19(1):281-293  PubMed ID: 36594093   DOI: 10.7150/ijbs.77987
21328  Chang JW, Lin YY, Tsai CH, Liu SC, He XY, Wu YS, Huang CC, Tang CH.  Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis.  Biochem Pharmacol  2023  115687  PubMed ID: 37481139   DOI: 10.1016/j.bcp.2023.115687
21495  Mao X, Yan X, Li C, Liu Y, Zhang Y, Lin N.  Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis.  Chin Med  2023  18(1):156  PubMed ID: 38037139   DOI: 10.1186/s13020-023-00863-0
21519  Jiang Y, Zhong S, Tan H, Fu Y, Lai J, Liu L, Weng J, Chen H, He S.  Study on the mechanism of action of Saposhnikovia divaricata and its key phytochemical on rheumatoid arthritis based on network pharmacology and bioinformatics.  J Ethnopharmacol  2023  117586  PubMed ID: 38104871   DOI: 10.1016/j.jep.2023.117586
17636  Mokuda S, Watanabe H, Kohno H, Ishitoku M, Araki K, Hirata S, Sugiyama E.  N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes  Cytotechnology   2022  74(4):503-514  PubMed ID: 35791402   DOI: 10.1007/s10616-022-00540-4
20557  Lin X, Tao C, Zhang R, Zhang M, Wang Q, Chen J.  N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes.  Phytomedicine  2022  95:153871  PubMed ID: 34902811   DOI: 10.1016/j.phymed.2021.153871
20626  Li L, Zhan M, Li M.  Circular RNA circ_0130438 suppresses TNF-α-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis.  Transpl Immunol  2022  101588  PubMed ID: 35358709   DOI: 10.1016/j.trim.2022.101588
16620  David Achudhan, Sunny Li-Yun Chang, Shan-Chi Liu, Yen-You Lin, Wei-Chien Huang, Yang-Chang Wu, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, Yueh-Hsiung Kuo, Chih-Hsin Tang  Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts  Food & Nutrition Research  2022  66  PubMed ID: 35783555   DOI: 10.29219/fnr.v66.8645
16745  Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q, Su X, Yan S, Su W, Zhang Y, Lin N.  A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis  Front Immunol  2022  13:912933  PubMed ID: 35799788   DOI: 10.3389/fimmu.2022.912933
16922  Fu M, Sang X, Cheng H.  Total glucosides of peony induce fibroblast-like synovial apoptosis, and ameliorate cartilage injury via blocking the NF-κB/STAT3 pathway  Ann Transl Med  2022  10(2):51  PubMed ID: 35282135   DOI: 10.21037/atm-21-6187
16987  Konishi H, Kanou SE, Yukimatsu R, Inui M, Sato M, Yamamoto N, Nakano M, Koshiba M.  Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A 2A receptor signaling  Sci Rep  2022  12(1):6033  PubMed ID: 35410356   DOI: 10.1038/s41598-022-10012-6
16999  Sueda Y, Okazaki R, Funaki Y, Hasegawa Y, Ishikawa H, Hirayama Y, Inui G, Harada T, Takata M, Morita M, Yamasaki A.  Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts  Yonago Acta Med  2022  65(2):111-125  PubMed ID: 35611061   DOI: 10.33160/yam.2022.05.001
17000  Sun X, Li KX, Figueiredo ML, Lin CC, Li BY, Yokota H.  Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling  Cancers (Basel)  2022  14(13):3039  PubMed ID: 35804814   DOI: 10.3390/cancers14133039
20977  Yu B, Chen Y, Chen E, Zuo F, Yuan Y, Zhao X, Xiao C.  LncRNA RNA XIST binding to GATA1 contributes to rheumatoid arthritis through its effects on proliferation of synovial fibroblasts and angiogenesis via regulation of CCN6.  Mol Immunol  2022  153:200-211  PubMed ID: 36542956   DOI: 10.1016/j.molimm.2022.12.004
21031  Xu L, Niu X, Liu Y, Liu L.  ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway.  Mediators Inflamm  2022  2022:4258742  PubMed ID: 36405992   DOI: 10.1155/2022/4258742
21659  Achudhan D, Liu SC, Lin YY, Lee HP, Wang SW, Huang WC, Wu YC, Kuo YH, Tang CH.  Antcin K inhibits VEGF-dependent angiogenesis in human rheumatoid arthritis synovial fibroblasts  J Food Biochem  2022  46(1):e14022  PubMed ID: 34841538   DOI: 10.1111/jfbc.14022
13169  Fu X, Song G, Ni R, Liu H, Xu Z, Zhang D, He F, Huang G.  LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a.  Rheumatology (Oxford)  2021    PubMed ID: 32810279   DOI: 10.1093/rheumatology/keaa395
14180  Gan D, Cheng W, Ke L, Sun AR, Jia Q, Chen J, Lin J, Li J, Xu Z, Zhang P.  Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis  Front Pharmacol  2021  12:631891  PubMed ID: 33746759   DOI: 10.3389/fphar.2021.631891
14833  Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N.  Metformin repositioning in rheumatoid arthritis  Clin Exp Rheumatol  2021  39(4):763-768  PubMed ID: 32828146   DOI: 10.55563/clinexprheumatol/zn2u9h
20292  Chen J, Li J, Chen J, Cheng W, Lin J, Ke L, Liu G, Bai X, Zhang P.  Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor.  J Orthop Translat  2021  28:100-107  PubMed ID: 33816113   DOI: 10.1016/j.jot.2021.01.003
20295  Kaihara K, Nakagawa S, Arai Y, Inoue H, Tsuchida S, Fujii Y, Kamada Y, Kishida T, Mazda O, Takahashi K.  Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α.  Int J Mol Sci  2021  22(8)  PubMed ID: 33918929   DOI: 10.3390/ijms22083898
15287  Yoon SS, Moon EY.  B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor  Int J Mol Sci  2021  22(13):7166  PubMed ID: 34281218   DOI: 10.3390/ijms22137166
15291  Matsumoto M, Liu J, Iwata K, Ibi M, Asaoka N, Zhang X, Katsuyama M, Matsuda M, Nabe T, Schröder K, Yabe-Nishimura C.  NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis  J Pharmacol Sci  2021  146(2):88-97  PubMed ID: 33941325   DOI: 10.1016/j.jphs.2021.01.009
20446  Mijiti N, Someya A, Nagaoka I.  Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells.  Exp Ther Med  2021  22(5):1300  PubMed ID: 34630655   DOI: 10.3892/etm.2021.10735
16272  Li C, Pan J, Xu C, Jin Z, Chen X.  A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking  Front Cell Dev Biol  2021  9:740266  PubMed ID: 35127697   DOI: 10.3389/fcell.2021.740266
16277  Chang TK, Zhong YH, Liu SC, Huang CC, Tsai CH, Lee HP, Wang SW, Hsu CJ, Tang CH.  Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway  Front Immunol  2021  12:737990  PubMed ID: 34659230   DOI: 10.3389/fimmu.2021.737990
16278  Achudhan D, Liu SC, Lin YY, Huang CC, Tsai CH, Ko CY, Chiang IP, Kuo YH, Tang CH.  Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis  Front Immunol  2021  12:790925  PubMed ID: 34975889   DOI: 10.3389/fimmu.2021.790925
16929  Lin J, Sun AR, Li J, Yuan T, Cheng W, Ke L, Chen J, Sun W, Mi S, Zhang P.  A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue  Front Bioeng Biotechnol  2021  9:764212  PubMed ID: 34869276   DOI: 10.3389/fbioe.2021.764212
16980  Chen X, Lin H, Chen J, Wu L, Zhu J, Ye Y, Chen S, Du H, Li J.  Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis  Front Pharmacol  2021  12:714566  PubMed ID: 34566640   DOI: 10.3389/fphar.2021.714566
16983  Law YY, Lee WF, Hsu CJ, Lin YY, Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF.  miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts  Aging (Albany NY)  2021  13(13):17227-17236  PubMed ID: 34198264   DOI: 10.18632/aging.203201
16991  Ba X, Huang Y, Shen P, Huang Y, Wang H, Han L, Lin WJ, Yan HJ, Xu LJ, Qin K, Chen Z, Tu SH.  WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway  Front Pharmacol  2021  12:696802  PubMed ID: 34646130   DOI: 10.3389/fphar.2021.696802
16995  Huang CC, Law YY, Liu SC, Hu SL, Lin JA, Chen CJ, Wang SW, Tang CH.  Adiponectin Promotes VEGF Expression in Rheumatoid Arthritis Synovial Fibroblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-106a-5p  Cells  2021  10(10):2627  PubMed ID: 34685605   DOI: 10.3390/cells10102627
17083  Han CK, Lee WF, Hsu CJ, Huang YL, Lin CY, Tsai CH, Huang CC, Fong YC, Wu MH, Liu JF, Tang CH.  DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts  J Cell Physiol  2021  236(12):8060-8069  PubMed ID: 34192347   DOI: 10.1002/jcp.30494
13031  Yamagishi Y, Someya A, Nagaoka I.  Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine.  Biomed Rep  2020    PubMed ID: 32440348   DOI: 10.3892/br.2020.1304
13058  Tsai MH, Chi MC, Hsu JF, Lee IT, Lin KM, Fang ML, Lee MH, Lee CW, Liu JF.  Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis.  Cells  2020    PubMed ID: 32498294   DOI: 10.3390/cells9061378
13149  Lee J, Yoon SS, Thuy PX, Moon EY.  Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426.  Biomol Ther (Seoul)  2020    PubMed ID: 32753567   DOI: 10.4062/biomolther.2020.110
13503  Wu H, He Y, Wu H, Zhou M, Xu Z, Xiong R, Yan F, Liu H.  Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes  Theranostics  2020  10(22):10092-10105  PubMed ID: 32929336   DOI: 10.7150/thno.44865
13519  Wu S, Wang J, Li J, Li F.  microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5  Inflammation  2020  43(2):441-454  PubMed ID: 32008163   DOI: 10.1007/s10753-019-01117-8
13540  Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS.  PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis  Biomol Ther (Seoul)  2020  28(2):172-183  PubMed ID: 31739383   DOI: 10.4062/biomolther.2019.153
13563  Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q.  Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model  Front Pharmacol  2020  11:45  PubMed ID: 32116720   DOI: 10.3389/fphar.2020.00045
13644  Hsiang-Ping Lee, Yang-Chang Wu, Bo-Cheng Chen, Shan-Chi Liu, Te-Mao Li, Wei-Chien Huang, Chin-Jung Hsu, Chih-Hsin Tang  Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways  Food and Agricultural Immunology  2020  21(740-750)    DOI: 10.1080/09540105.2020.1766426
13645  Kanai T, Kondo N, Okada M, Sano H, Okumura G, Kijima Y, Ogose A, Kawashima H, Endo N.  The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3  J Orthop Surg Res  2020  15(1):87  PubMed ID: 32131874   DOI: 10.1186/s13018-020-01595-9
14843  Cheng WX, Zhong S, Meng XB, Zheng NY, Zhang P, Wang Y, Qin L, Wang XL  Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats  J Pharmacol Exp Ther  2020  373(2):302-310  PubMed ID: 32029577   DOI: 10.1124/jpet.119.262907
14856  Liu C, He L, Wang J, Wang Q, Sun C, Li Y, Jia K, Wang J, Xu T, Ming R, Wang Q, Lin N.  Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways  J Ethnopharmacol  2020  260:113039  PubMed ID: 32497675   DOI: 10.1016/j.jep.2020.113039
16989  Meng X, Cheng W, Zhong S, Zhang P, Qin L, Wang X.  Anti-inflammatory effects of Jingshu Keli capsule and its components on human synoviocyte MH7A cells  Arthroplasty  2020  2(1):7  PubMed ID: 35236422   DOI: 10.1186/s42836-020-00026-8
17001  Zhang Y, Wang X, Li W, Wang H, Yin X, Jiang F, Su X, Chen W, Li T, Mao X, Guo M, Jiang Q, Lin N.  Inferences of individual differences in response to tripterysium glycosides across patients with Rheumatoid arthritis using a novel ceRNA regulatory axis  Clin Transl Med  2020  10(6):e185  PubMed ID: 33135351   DOI: 10.1002/ctm2.185
21896  Hou SM, Chen PC, Lin CM, Fang ML, Chi MC, Liu JF.  CXCL1 contributes to IL-6 expression in osteoarthritis and rheumatoid arthritis synovial fibroblasts by CXCR2, c-Raf, MAPK, and AP-1 pathway  Arthritis Res Ther . 2020 Oct 21;22(1):251  2020  22(1):251  PubMed ID: 33087182   DOI: 10.1186/s13075-020-02331-8
11298  Ma J, Wang X, Lv T, Liu J, Ren Y, Zhang J, Zhang Y.  Effects of Ghrelin on the Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocyte MH7A Cells.  Biol. Pharm. Bull.  2019    PubMed ID: 30429411   DOI: 10.1248/bpb.b18-00285
11434  Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I.  MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling.  Int J Mol Sci  2019    PubMed ID: 30769772   DOI: 10.3390/ijms20040809
11529  Meng D, Li J, Li H, Wang K.  Salvianolic acid B remits LPS-induced injury by up-regulating miR-142-3p in MH7A cells.  Biomed. Pharmacother.  2019    PubMed ID: 31022596   DOI: 10.1016/j.biopha.2019.108876
11688  Wen-Xiang Cheng, Huan Huang, Jian-Hai Chen, Tian-Tian Zhang, Guo-Yuan Zhu, Zheng-Tan Zheng, Jie-Tao Lin, Yi-Ping Hu, Yong Zhang, Xue-Ling Bai, Yan Wang, Zhan-Wang Xu, Bing Song, Yi-Ying Mao, Fei Yang, Peng Zhang  Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway  Journal of Orthopaedic Translation  2019    PubMed ID: 32440504   DOI: 10.1016/j.jot.2019.07.007
12330  Jia Q, Wang T, Wang X, Xu H, Liu Y, Wang Y, Shi Q, Liang Q.  Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes  Front Pharmacol  2019  10:94  PubMed ID: 30809149   DOI: 10.3389/fphar.2019.00094
12519  Chen H, Liang Q, Zhou X, Wang X.  Preparative separation of the flavonoid fractions from Periploca forrestii Schltr. ethanol extracts using macroporous resin combined with HPLC analysis and evaluation of their biological activities  J Sep Sci  2019  42(3):650-661  PubMed ID: 30461196   DOI: 10.1002/jssc.201800422
12520  Huang CC, Chiou CH, Liu SC, Hu SL, Su CM, Tsai CH, Tang CH.  Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis  J Pineal Res  2019  66(3):e12560  PubMed ID: 30648758   DOI: 10.1111/jpi.12560
10840  Jia W, Wu W, Yang D, Xiao C, Huang M, Long F, Su Z, Qin M, Liu X, Zhu YZ.  GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis.  Cell Death Dis  2018  9:503  PubMed ID: 29717129   DOI: 10.1038/s41419-018-0570-5
11091  Takeno M, Kitagawa S, Yamanaka J, Teramoto M, Tomita H, Shirai N, Itoh S, Hida S, Hayakawa K, Onozaki K, Takii T.  5-Hydroxy-2-methylpyridine Isolated from Cigarette Smoke Condensate Aggravates Collagen-Induced Arthritis in Mice.  Biol. Pharm. Bull.  2018  41(6):877-884  PubMed ID: 29863076   DOI: 10.1248/bpb.b17-00982
11169  Wang X, Wang X, Sun J, Fu S.  An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome-protamine-DNA-siRNA complex with cell permeable peptides.  Int. J. Mol. Med.  2018  42(5):2393-2402  PubMed ID: 30106091   DOI: 10.3892/ijmm.2018.3815
11203  Zhong F, Xu J, Yang X, Zhang Q, Gao Z, Deng Y, Zhang L, Yu C.  miR-145 eliminates lipopolysaccharides-induced inflammatory injury in human fibroblast-like synoviocyte MH7A cells.  J. Cell. Biochem.  2018    PubMed ID: 30191608   DOI: 10.1002/jcb.27341
4296  He L, Liu C, Sun C, Wang J, Zhi K, Sun D, Wang H, Wang Q, Lin N.  Wu-Tou Decoction Inhibits Angiogenesis in Experimental Arthritis by Targeting VEGFR2 Signaling Pathway.  Rejuvenation Res  2018    PubMed ID: 29385909   DOI: 10.1089/rej.2017.2011
4297  Wu J, Fan W, Ma L, Geng X.  miR-708-5p promotes fibroblast-like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway.  Drug Des Devel Ther  2018    PubMed ID: 30349197   DOI: 10.2147/DDDT.S177128
14551  Takamura Y, Aoki W, Satomura A, Shibasaki S, Ueda M.  Small RNAs detected in exosomes derived from the MH7A synovial fibroblast cell line with TNF-α stimulation  PLoS One  2018  13(8):e0201851  PubMed ID: 30096164   DOI: 10.1371/journal.pone.0201851
14904  Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY.  Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis  Cell Death Dis  2018  9(3):401  PubMed ID: 29540697   DOI: 10.1038/s41419-018-0433-0
10252  Lee JW, Lee J, Um SH, Moon EY.  Synovial cell death is regulated by TNF-α-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1α.  Cell Death Dis  2017  8:e2727  PubMed ID: 28383556   DOI: 10.1038/cddis.2017.26
10404  Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N.  Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.  Autoimmunity  2017  50:329-335  PubMed ID: 28682648   DOI: 10.1080/08916934.2017.1344970
10932  Shupeng WU, Jing WANG, Fang LI  Role of SNF5 in rheumatoid arthritis by up-regulation of p16 and inactivation of JNK 1 pathway  Turkish Journal of Biology  2017  41: 535-542    DOI: 10.3906/biy-1610-40
14250  Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I.  Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells  Mol Med Rep  2017  16(2):1353-1359  PubMed ID: 28586015   DOI: 10.3892/mmr.2017.6691
14451  Hu SL, Chang AC, Huang CC, Tsai CH, Lin CC, Tang CH.  Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p  Front Immunol  2017  8:1747  PubMed ID: 29276516   DOI: 10.3389/fimmu.2017.01747
14486  Moriya N, Shibasaki S, Karasaki M, Iwasaki T.  The Impact of MicroRNA-223-3p on IL-17 Receptor D Expression in Synovial Cells  PLoS One  2017  12(1):e0169702  PubMed ID: 28056105   DOI: 10.1371/journal.pone.0169702
14590  Tang Q, Cui J, Tian Z, Sun J, Wang Z, Chang S, Zhu S.  Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes  Int J Nanomedicine  2017  12:381-393  PubMed ID: 28123298   DOI: 10.2147/IJN.S120902
14625  Hashiguchi M, Suzuki K, Kaneko K, Nagaoka I.  Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate  Mol Med Rep  2017  15(6):4398-4404  PubMed ID: 28487948   DOI: 10.3892/mmr.2017.6541
7143  Imamura H, Yoshina S, Ikari K, Miyazawa K, Momohara S, Mitani S.  Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.  Mod Rheumatol  2016  26:507-16  PubMed ID: 26587663   DOI: 10.3109/14397595.2015.1112481
7144  Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.  Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis.  Autoimmunity  2016  49:109-14  PubMed ID: 26584911   DOI: 10.3109/08916934.2015.1113405
9866  Wu WJ, Jia WW, Liu XH, Pan LL, Zhang QY, Yang D, Shen XY, Liu L, Zhu YZ.  S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway.  Redox Biol  2016  10:157-167  PubMed ID: 27744121   DOI: 10.1016/j.redox.2016.08.011
9879  Someya A, Ikegami T, Sakamoto K, Nagaoka I.  Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms.  PLoS ONE  2016  11:e0165158  PubMed ID: 27776166   DOI: 10.1371/journal.pone.0165158
9157  Seiji Shibasaki, Miki Karasaki, Shunsuke Aburaya, Hironobu Morisaka, Yumiko Takeda, Wataru Aoki, Sachie Kitano, Masayasu Kitano, Mitsuyoshi Ueda, Hajime Sano, Tsuyoshi Iwasaki  A Comparative Proteomics Study of a Synovial Cell Line Stimulated With TNF-α  FEBS Open Bio  2016  6 (5), 418-24  PubMed ID: 27419047   DOI: 10.1002/2211-5463.12049
14142  Ferguson GD, Delgado M, Plantevin-Krenitsky V, Jensen-Pergakes K, Bates RJ, Torres S, Celeridad M, Brown H, Burnett K, Nadolny L, Tehrani L, Packard G, Pagarigan B, Haelewyn J, Nguyen T, Xu L, Tang Y, Hickman M, Baculi F, Pierce S, Miyazawa K, Jackson P, Chamberlain P, LeBrun L, Xie W, Bennett B, Blease K.  A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation  PLoS One  2016  11(1):e0145705  PubMed ID: 26756335   DOI: 10.1371/journal.pone.0145705
7188  Jia Q, Cheng W, Yue Y, Hu Y, Zhang J, Pan X, Xu Z, Zhang P.  Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways.  Int. Immunopharmacol.  2015  29:884-890  PubMed ID: 26453509   DOI: 10.1016/j.intimp.2015.08.026
17002  Wang MJ, Huang Y, Huang RY, Chen XM, Zhou YY, Yu WL, Chu YL, Huang QC.  Determination of role of thromboxane A2 in rheumatoid arthritis  Discov Med  2015  19(102):23-3  PubMed ID: 25636958  
17444  Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.  Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis  Autoimmunity  2015  48(4):251-8  PubMed ID: 25352179   DOI: 10.3109/08916934.2014.976631
19203  Li J, Li J, Yue Y, Hu Y, Cheng W, Liu R, Pan X, Zhang P.  Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells  Drug Des Devel Ther  2014  8:315-23  PubMed ID: 24669186   DOI: 10.2147/DDDT.S52354
12290  Hideya Igarashi, Hiroyasu Hirano, Ayano Yahagi, Taro Saika, Katsuhiko Ishihara  Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A  Clin Immunol  2014  150(1):12-21  PubMed ID: 24316591   DOI: 10.1016/j.clim.2013.10.013
16993  Shibasaki S, Tsunemi S, Kitano S, Sekiguchi M, Sano H, Iwasaki T.  Differential regulation of c-Met signaling pathways for synovial cell function  Springerplus  2014  3:554  PubMed ID: 25332857   DOI: 10.1186/2193-1801-3-554
16996  Shibasaki S, Karasaki M, Gräslund T, Nygren PÅ, Sano H, Iwasaki T.  Inhibitory effects of H-Ras/Raf-1-binding affibody molecules on synovial cell function  AMB Express  2014  4(1):82  PubMed ID: 26267111   DOI: 10.1186/s13568-014-0082-3
19204  Kloesch B, Becker T, Dietersdorfer E, Kiener H, Steiner G.  Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes  Int Immunopharmacol  2013  15(2):400-5  PubMed ID: 23347846   DOI: 10.1016/j.intimp.2013.01.003
10988  Geun-Hee Lee, Jiyoung Lee, Jae-Wook Lee, Whan Soo Choi, Eun-Yi Moon  B cell activating factor-dependent expression of vascular endothelial growth factor in MH7A human synoviocytes stimulated with tumor necrosis factor-α  Int Immunopharmacol  2013  17(1):142-7  PubMed ID: 23684916   DOI: 10.1016/j.intimp.2013.04.026
7598  Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I.  Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis.  Mod Rheumatol  2012  22:228-37  PubMed ID: 22203215   DOI: 10.1007/s10165-011-0564-y
7631  Igarashi H, Yahagi A, Saika T, Hashimoto J, Tomita T, Yoshikawa H, Ishihara K.  A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis.  Immunol. Lett.  2012  141:246-53  PubMed ID: 22093807   DOI: 10.1016/j.imlet.2011.10.011
7800  Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T.  Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis.  Mod Rheumatol  2012  22:128-36  PubMed ID: 21633911   DOI: 10.1007/s10165-011-0475-y
19132  Patricia Wardwell, Paritosh Wattamwar, Thomas Dziubla, Rebecca Bader  Control of the inflammatory response with poly(trolox ester) antioxidant nanoparticles  2012 38th Annual Northeast Bioengineering Conference (NEBEC)  2012      DOI: 10.1109/nebc.2012.6207082
19205  Shibasaki S, Fujita A, Usui C, Watanabe S, Kitano S, Sano H, Iwasaki T.  Effect of transient expression of fluorescent protein probes in synovial and myoblast cell lines  Springerplus  2012  1(1):36  PubMed ID: 23503703   DOI: 10.1186/2193-1801-1-36
19206  NAN ZHANG, REBECCA A. BADER  SYNTHESIS AND CHARACTERIZATION OF POLYSIALIC ACID-N-TRIMETHYL CHITOSAN NANOPARTICLES FOR DRUG DELIVERY  SYNTHESIS AND CHARACTERIZATION OF POLYSIALIC ACID-N-TRIMETHYL CHITOSAN NANOPARTICLES FOR DRUG DELIVERY  2012  02:1241003    DOI: 10.1142/s1793984412410036
19207  Wagoner KL, Bader RA.  Evaluation of SV40-transformed synovial fibroblasts in the study of rheumatoid arthritis pathogenesis  Rheumatol Int  2012  32(7):1885-91  PubMed ID: 21445545   DOI: 10.1007/s00296-011-1913-z
19208  Takeshita H, Kitano M, Iwasaki T, Kitano S, Tsunemi S, Sato C, Sekiguchi M, Azuma N, Miyazawa K, Hla T, Sano H.  Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis  Biochem Biophys Res Commun  2012  419(2):154-9  PubMed ID: 22326262   DOI: 10.1016/j.bbrc.2012.01.103
12717  Nakayama H, Yaguchi T, Yoshiya S, Nishizaki T.  Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner  Rheumatol Int . 2012 Jan;32(1):151-7  2012  32(1):151-7  PubMed ID: 20697895   DOI: 10.1007/s00296-010-1598-8
16936  Haas S, Straub RH.  Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoart  Arthritis Res Ther  2012  14(3):R122  PubMed ID: 22621205   DOI: 10.1186/ar3852
7779  Seong AR, Yoo JY, Choi K, Lee MH, Lee YH, Lee J, Jun W, Kim S, Yoon HG.  Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells.  Biochem. Biophys. Res. Commun.  2011  410:581-6  PubMed ID: 21683061   DOI: 10.1016/j.bbrc.2011.06.029
7997  Bader RA, Silvers AL, Zhang N.  Polysialic acid-based micelles for encapsulation of hydrophobic drugs.  Biomacromolecules  2011  12:314-20  PubMed ID: 21218771   DOI: 10.1021/bm1008603
16997  Araki H, Imaoka A, Kuboyama N, Abiko Y.  Reduction of interleukin-6 expression in human synoviocytes and rheumatoid arthritis rat joints by linear polarized near infrared light (Superlizer) irradiation  Laser Ther   2011  20(4):293-300  PubMed ID: 24155540   DOI: 10.5978/islsm.11-or_01
16998  Igarashi M, Kaga I, Takamori Y, Sakamoto K, Miyazawa K, Nagaoka I.  Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes  Int J Mol Med  2011  27(6):821-7  PubMed ID: 21455564   DOI: 10.3892/ijmm.2011.662
8289  Bader RA, Wagoner KL.  Modulation of the response of rheumatoid arthritis synovial fibroblasts to proinflammatory stimulants with cyclic tensile strain.  Cytokine  2010  51:35-41  PubMed ID: 20399680   DOI: 10.1016/j.cyto.2010.03.015
16994  Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H.  Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model  Clin Immunol  2010  136(2):197-204  PubMed ID: 20421177   DOI: 10.1016/j.clim.2010.03.428
8449  Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K, Sekigawa I.  Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis.  Arthritis Res. Ther.  2009  11:R174  PubMed ID: 19922639   DOI: 10.1186/ar2863
19202  Su J, Yu J, Ren T, Zhang W, Zhang Y, Liu X, Sun T, Lu H, Miyazawa K, Yao L.  Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis  Mol Cell Biochem  2009  330(1-2):141-52  PubMed ID: 19415460   DOI: 10.1007/s11010-009-0127-0
16990  Shibata Y, Kasai H, Shimada M, Koitabashi T, Arai T, Sai R, Terao H, Horikiri M, Negishi H, Miyazawa K, Abiko Y.  IL-1β stimulates IL-8 production, including prostaglandin E2 receptor EP4-triggered pathways, in synoviocyte MH7A cells  Mol Med Rep  2009  ;2(3):359-63  PubMed ID: 21475837   DOI: 10.3892/mmr_00000108
19201  Suzuki T, Tsutsumi A, Suzuki H, Suzuki E, Sugihara M, Muraki Y, Hayashi T, Chino Y, Goto D, Matsumoto I, Ito S, Miyazawa K, Sumida T.  Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals  Mod Rheumatol  2008  18(5):472-9  PubMed ID: 18536977   DOI: 10.1007/s10165-008-0085-5
19209  Brühl H, Mack M, Niedermeier M, Lochbaum D, Schölmerich J, Straub RH.  Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes  Rheumatology (Oxford)  2008  47(12):1771-4  PubMed ID: 18838387   DOI: 10.1093/rheumatology/ken383
19210  Ha JE, Choi YE, Jang J, Yoon CH, Kim HY, Bae YS.  FLIP and MAPK play crucial roles in the MLN51-mediated hyperproliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis  FEBS J  2008  275(14):3546-55  PubMed ID: 18513326   DOI: 10.1111/j.1742-4658.2008.06500.x
19211  Endo S, Hiramatsu N, Hayakawa K, Okamura M, Kasai A, Tagawa Y, Sawada N, Yao J, Kitamura M.  Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70  Mol Pharmacol  2007  72(5):1337-48  PubMed ID: 17702888   DOI: 10.1124/mol.107.039164
19212  Maeda T, Hirayama M, Kobayashi D, Miyazawa K, Tamai I.  Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines  Drug Metab Dispos  2007  ;35(3):394-401  PubMed ID: 17142562   DOI: 10.1124/dmd.106.012112
18877  Heum Park J, Cho Han D, Kim J, Hyung Hong S, Lee SK, Seog Yoon K, Min Kim J, Son KH, Miyazawa K, Kwon BM.  Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen  Life Sci  2006  78(19):2204-12  PubMed ID: 16289138   DOI: 10.1016/j.lfs.2005.09.029
19213  Kim SJ, Shin HH, Park SY, Lee DS, Lee EA, Cho SD, Cho HR, Miyazawa K, Choi HS.  Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells  Osteoarthritis Cartilage  2006  14(2):146-53  PubMed ID: 16242974   DOI: 10.1016/j.joca.2005.08.012
10354  Masaji Morita 1, Yoshiko Banno, Taikoh Dohjima, Satoshi Nozawa, Kazunari Fushimi, De-Gang Fan, Takatoshi Ohno, Keiji Miyazawa, Naxin Liu, Katsuji Shimizu  Mu-calpain Is Involved in the Regulation of TNF-alpha-induced Matrix metalloproteinase-3 Release in a Rheumatoid Synovial Cell Line  Biochem Biophys Res Commun  2006  343(3):937-42  PubMed ID: 16574073   DOI: 10.1016/j.bbrc.2006.02.155
16988  Han SK, Jeon SJ, Miyazawa K, Yi SY, Yoo YS.  Enhancement of anti-inflammatory tendency by SB203580, p38alpha specific inhibitor, in human fibroblast-like synoviocyte cell line, MH7A  Rheumatol Int  2006  26(11):972-8  PubMed ID: 16532349   DOI: 10.1007/s00296-006-0109-4
16992  Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY.  Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression  Arthritis Rheum  2006  54(3):742-53  PubMed ID: 16508938   DOI: 10.1002/art.21668
19197  Shibata Y, Ogura N, Yamashiro K, Takashiba S, Kondoh T, Miyazawa K, Matsui M, Abiko Y.  Anti-inflammatory effect of linear polarized infrared irradiation on interleukin-1beta-induced chemokine production in MH7A rheumatoid synovial cells  Lasers Med Sci  2005  20(3-4):109-13  PubMed ID: 16047084   DOI: 10.1007/s10103-005-0350-1
19214  Sun HB, Nalim R, Yokota H.  Expression and activities of matrix metalloproteinases under oscillatory shear in IL-1-stimulated synovial cells  Connect Tissue Res  2003  44(1):42-9.  PubMed ID: 12945803  
14332  Sun HB, Liu Y, Qian L, Yokota H.  Model-based analysis of matrix metalloproteinase expression under mechanical shear  Ann Biomed Eng  2003  31(2):171-80  PubMed ID: 12627825   DOI: 10.1114/1.1540635
19215  Sun HB, Malacinski GM, Yokota H.  Promoter competition assay for analyzing gene regulation in joint tissue engineering  Front Biosci  2002  7:a169-74  PubMed ID: 12133815   DOI: 10.2741/a751
19216  Sun HB, Yokota H.  Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells  Matrix Biol  2002  21(3):263-70  PubMed ID: 12009332   DOI: 10.1016/s0945-053x(02)00003-3
19217  Sun HB, Yokota H.  Altered mRNA level of matrix metalloproteinase-13 in MH7A synovial cells under mechanical loading and unloading  Bone  2001  28(4):399-403  PubMed ID: 11336920   DOI: 10.1016/s8756-3282(00)00459-2
15416  Sun HB, Yokota H.  Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cells under mechanical stimuli  Bone  2001  28(3):303-9  PubMed ID: 11248661   DOI: 10.1016/s8756-3282(00)00454-3



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