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17608
Ni R, Liu H, Song G, Fu X, Deng B, Xu Z, Dai S, Huang G.
MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5
Int J Rheum Dis
2023
26(4):699-709
PubMed ID: 36843205
DOI: 10.1111/1756-185X.14622
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17771
Liu F, Zhan S, Zhang P, Jia C, Zhu Q, Dai Q, Yu M, Cheng L, Xiong L, Sun F, Xia P, Zhang X, Hu J.
Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula
Front Physiol
2023
14:1138947
PubMed ID: 36969583
DOI: 10.3389/fphys.2023.1138947
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21328
Chang JW, Lin YY, Tsai CH, Liu SC, He XY, Wu YS, Huang CC, Tang CH.
Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis.
Biochem Pharmacol
2023
115687
PubMed ID: 37481139
DOI: 10.1016/j.bcp.2023.115687
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17636
Mokuda S, Watanabe H, Kohno H, Ishitoku M, Araki K, Hirata S, Sugiyama E.
N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes
Cytotechnology
2022
74(4):503-514
PubMed ID: 35791402
DOI: 10.1007/s10616-022-00540-4
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20557
Lin X, Tao C, Zhang R, Zhang M, Wang Q, Chen J.
N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes.
Phytomedicine
2022
95:153871
PubMed ID: 34902811
DOI: 10.1016/j.phymed.2021.153871
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20626
Li L, Zhan M, Li M.
Circular RNA circ_0130438 suppresses TNF-α-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis.
Transpl Immunol
2022
101588
PubMed ID: 35358709
DOI: 10.1016/j.trim.2022.101588
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16620
David Achudhan, Sunny Li-Yun Chang, Shan-Chi Liu, Yen-You Lin, Wei-Chien Huang, Yang-Chang Wu, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, Yueh-Hsiung Kuo, Chih-Hsin Tang
Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts
Food & Nutrition Research
2022
66
PubMed ID: 35783555
DOI: 10.29219/fnr.v66.8645
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16745
Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q, Su X, Yan S, Su W, Zhang Y, Lin N.
A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis
Front Immunol
2022
13:912933
PubMed ID: 35799788
DOI: 10.3389/fimmu.2022.912933
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16922
Fu M, Sang X, Cheng H.
Total glucosides of peony induce fibroblast-like synovial apoptosis, and ameliorate cartilage injury via blocking the NF-κB/STAT3 pathway
Ann Transl Med
2022
10(2):51
PubMed ID: 35282135
DOI: 10.21037/atm-21-6187
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16987
Konishi H, Kanou SE, Yukimatsu R, Inui M, Sato M, Yamamoto N, Nakano M, Koshiba M.
Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A 2A receptor signaling
Sci Rep
2022
12(1):6033
PubMed ID: 35410356
DOI: 10.1038/s41598-022-10012-6
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16999
Sueda Y, Okazaki R, Funaki Y, Hasegawa Y, Ishikawa H, Hirayama Y, Inui G, Harada T, Takata M, Morita M, Yamasaki A.
Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts
Yonago Acta Med
2022
65(2):111-125
PubMed ID: 35611061
DOI: 10.33160/yam.2022.05.001
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17000
Sun X, Li KX, Figueiredo ML, Lin CC, Li BY, Yokota H.
Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling
Cancers (Basel)
2022
14(13):3039
PubMed ID: 35804814
DOI: 10.3390/cancers14133039
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Yu B, Chen Y, Chen E, Zuo F, Yuan Y, Zhao X, Xiao C.
LncRNA RNA XIST binding to GATA1 contributes to rheumatoid arthritis through its effects on proliferation of synovial fibroblasts and angiogenesis via regulation of CCN6.
Mol Immunol
2022
153:200-211
PubMed ID: 36542956
DOI: 10.1016/j.molimm.2022.12.004
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21031
Xu L, Niu X, Liu Y, Liu L.
ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway.
Mediators Inflamm
2022
2022:4258742
PubMed ID: 36405992
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Fu X, Song G, Ni R, Liu H, Xu Z, Zhang D, He F, Huang G.
LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a.
Rheumatology (Oxford)
2021
PubMed ID: 32810279
DOI: 10.1093/rheumatology/keaa395
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14180
Gan D, Cheng W, Ke L, Sun AR, Jia Q, Chen J, Lin J, Li J, Xu Z, Zhang P.
Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis
Front Pharmacol
2021
12:631891
PubMed ID: 33746759
DOI: 10.3389/fphar.2021.631891
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Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N.
Metformin repositioning in rheumatoid arthritis
Clin Exp Rheumatol
2021
39(4):763-768
PubMed ID: 32828146
DOI: 10.55563/clinexprheumatol/zn2u9h
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20292
Chen J, Li J, Chen J, Cheng W, Lin J, Ke L, Liu G, Bai X, Zhang P.
Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor.
J Orthop Translat
2021
28:100-107
PubMed ID: 33816113
DOI: 10.1016/j.jot.2021.01.003
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Kaihara K, Nakagawa S, Arai Y, Inoue H, Tsuchida S, Fujii Y, Kamada Y, Kishida T, Mazda O, Takahashi K.
Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α.
Int J Mol Sci
2021
22(8)
PubMed ID: 33918929
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Yoon SS, Moon EY.
B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor
Int J Mol Sci
2021
22(13):7166
PubMed ID: 34281218
DOI: 10.3390/ijms22137166
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Matsumoto M, Liu J, Iwata K, Ibi M, Asaoka N, Zhang X, Katsuyama M, Matsuda M, Nabe T, Schröder K, Yabe-Nishimura C.
NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis
J Pharmacol Sci
2021
146(2):88-97
PubMed ID: 33941325
DOI: 10.1016/j.jphs.2021.01.009
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20446
Mijiti N, Someya A, Nagaoka I.
Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells.
Exp Ther Med
2021
22(5):1300
PubMed ID: 34630655
DOI: 10.3892/etm.2021.10735
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16272
Li C, Pan J, Xu C, Jin Z, Chen X.
A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking
Front Cell Dev Biol
2021
9:740266
PubMed ID: 35127697
DOI: 10.3389/fcell.2021.740266
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Chang TK, Zhong YH, Liu SC, Huang CC, Tsai CH, Lee HP, Wang SW, Hsu CJ, Tang CH.
Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway
Front Immunol
2021
12:737990
PubMed ID: 34659230
DOI: 10.3389/fimmu.2021.737990
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16278
Achudhan D, Liu SC, Lin YY, Huang CC, Tsai CH, Ko CY, Chiang IP, Kuo YH, Tang CH.
Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis
Front Immunol
2021
12:790925
PubMed ID: 34975889
DOI: 10.3389/fimmu.2021.790925
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16929
Lin J, Sun AR, Li J, Yuan T, Cheng W, Ke L, Chen J, Sun W, Mi S, Zhang P.
A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue
Front Bioeng Biotechnol
2021
9:764212
PubMed ID: 34869276
DOI: 10.3389/fbioe.2021.764212
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Chen X, Lin H, Chen J, Wu L, Zhu J, Ye Y, Chen S, Du H, Li J.
Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis
Front Pharmacol
2021
12:714566
PubMed ID: 34566640
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Law YY, Lee WF, Hsu CJ, Lin YY, Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF.
miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts
Aging (Albany NY)
2021
13(13):17227-17236
PubMed ID: 34198264
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Ba X, Huang Y, Shen P, Huang Y, Wang H, Han L, Lin WJ, Yan HJ, Xu LJ, Qin K, Chen Z, Tu SH.
WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway
Front Pharmacol
2021
12:696802
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Huang CC, Law YY, Liu SC, Hu SL, Lin JA, Chen CJ, Wang SW, Tang CH.
Adiponectin Promotes VEGF Expression in Rheumatoid Arthritis Synovial Fibroblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-106a-5p
Cells
2021
10(10):2627
PubMed ID: 34685605
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Han CK, Lee WF, Hsu CJ, Huang YL, Lin CY, Tsai CH, Huang CC, Fong YC, Wu MH, Liu JF, Tang CH.
DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts
J Cell Physiol
2021
236(12):8060-8069
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Yamagishi Y, Someya A, Nagaoka I.
Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine.
Biomed Rep
2020
PubMed ID: 32440348
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Tsai MH, Chi MC, Hsu JF, Lee IT, Lin KM, Fang ML, Lee MH, Lee CW, Liu JF.
Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis.
Cells
2020
PubMed ID: 32498294
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Lee J, Yoon SS, Thuy PX, Moon EY.
Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426.
Biomol Ther (Seoul)
2020
PubMed ID: 32753567
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Wu H, He Y, Wu H, Zhou M, Xu Z, Xiong R, Yan F, Liu H.
Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes
Theranostics
2020
10(22):10092-10105
PubMed ID: 32929336
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Wu S, Wang J, Li J, Li F.
microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5
Inflammation
2020
43(2):441-454
PubMed ID: 32008163
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Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS.
PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis
Biomol Ther (Seoul)
2020
28(2):172-183
PubMed ID: 31739383
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Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q.
Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
Front Pharmacol
2020
11:45
PubMed ID: 32116720
DOI: 10.3389/fphar.2020.00045
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13644
Hsiang-Ping Lee, Yang-Chang Wu, Bo-Cheng Chen, Shan-Chi Liu, Te-Mao Li, Wei-Chien Huang, Chin-Jung Hsu, Chih-Hsin Tang
Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways
Food and Agricultural Immunology
2020
21(740-750)
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Kanai T, Kondo N, Okada M, Sano H, Okumura G, Kijima Y, Ogose A, Kawashima H, Endo N.
The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3
J Orthop Surg Res
2020
15(1):87
PubMed ID: 32131874
DOI: 10.1186/s13018-020-01595-9
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14843
Cheng WX, Zhong S, Meng XB, Zheng NY, Zhang P, Wang Y, Qin L, Wang XL
Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats
J Pharmacol Exp Ther
2020
373(2):302-310
PubMed ID: 32029577
DOI: 10.1124/jpet.119.262907
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14852
Benjamin Yüksel, Klaus Schwarz, Reiner Creutzburg
AI-based anomaly detection for cyberattacks on Windows systems - Creation of a prototype for automated monitoring of the process environment
Electronic Imaging
2020
331-1-331-13
DOI: 10.2352/issn.2470-1173.2020.3.mobmu-304
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Liu C, He L, Wang J, Wang Q, Sun C, Li Y, Jia K, Wang J, Xu T, Ming R, Wang Q, Lin N.
Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways
J Ethnopharmacol
2020
260:113039
PubMed ID: 32497675
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Meng X, Cheng W, Zhong S, Zhang P, Qin L, Wang X.
Anti-inflammatory effects of Jingshu Keli capsule and its components on human synoviocyte MH7A cells
Arthroplasty
2020
2(1):7
PubMed ID: 35236422
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Zhang Y, Wang X, Li W, Wang H, Yin X, Jiang F, Su X, Chen W, Li T, Mao X, Guo M, Jiang Q, Lin N.
Inferences of individual differences in response to tripterysium glycosides across patients with Rheumatoid arthritis using a novel ceRNA regulatory axis
Clin Transl Med
2020
10(6):e185
PubMed ID: 33135351
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Ma J, Wang X, Lv T, Liu J, Ren Y, Zhang J, Zhang Y.
Effects of Ghrelin on the Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocyte MH7A Cells.
Biol. Pharm. Bull.
2019
PubMed ID: 30429411
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Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I.
MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling.
Int J Mol Sci
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Meng D, Li J, Li H, Wang K.
Salvianolic acid B remits LPS-induced injury by up-regulating miR-142-3p in MH7A cells.
Biomed. Pharmacother.
2019
PubMed ID: 31022596
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Wen-Xiang Cheng, Huan Huang, Jian-Hai Chen, Tian-Tian Zhang, Guo-Yuan Zhu, Zheng-Tan Zheng, Jie-Tao Lin, Yi-Ping Hu, Yong Zhang, Xue-Ling Bai, Yan Wang, Zhan-Wang Xu, Bing Song, Yi-Ying Mao, Fei Yang, Peng Zhang
Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway
Journal of Orthopaedic Translation
2019
PubMed ID: 32440504
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Jia Q, Wang T, Wang X, Xu H, Liu Y, Wang Y, Shi Q, Liang Q.
Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes
Front Pharmacol
2019
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Chen H, Liang Q, Zhou X, Wang X.
Preparative separation of the flavonoid fractions from Periploca forrestii Schltr. ethanol extracts using macroporous resin combined with HPLC analysis and evaluation of their biological activities
J Sep Sci
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Huang CC, Chiou CH, Liu SC, Hu SL, Su CM, Tsai CH, Tang CH.
Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis
J Pineal Res
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66(3):e12560
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Jia W, Wu W, Yang D, Xiao C, Huang M, Long F, Su Z, Qin M, Liu X, Zhu YZ.
GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis.
Cell Death Dis
2018
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Takeno M, Kitagawa S, Yamanaka J, Teramoto M, Tomita H, Shirai N, Itoh S, Hida S, Hayakawa K, Onozaki K, Takii T.
5-Hydroxy-2-methylpyridine Isolated from Cigarette Smoke Condensate Aggravates Collagen-Induced Arthritis in Mice.
Biol. Pharm. Bull.
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41(6):877-884
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Wang X, Wang X, Sun J, Fu S.
An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome-protamine-DNA-siRNA complex with cell permeable peptides.
Int. J. Mol. Med.
2018
42(5):2393-2402
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Zhong F, Xu J, Yang X, Zhang Q, Gao Z, Deng Y, Zhang L, Yu C.
miR-145 eliminates lipopolysaccharides-induced inflammatory injury in human fibroblast-like synoviocyte MH7A cells.
J. Cell. Biochem.
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He L, Liu C, Sun C, Wang J, Zhi K, Sun D, Wang H, Wang Q, Lin N.
Wu-Tou Decoction Inhibits Angiogenesis in Experimental Arthritis by Targeting VEGFR2 Signaling Pathway.
Rejuvenation Res
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miR-708-5p promotes fibroblast-like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway.
Drug Des Devel Ther
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Takamura Y, Aoki W, Satomura A, Shibasaki S, Ueda M.
Small RNAs detected in exosomes derived from the MH7A synovial fibroblast cell line with TNF-α stimulation
PLoS One
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Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY.
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis
Cell Death Dis
2018
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Synovial cell death is regulated by TNF-α-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1α.
Cell Death Dis
2017
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Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N.
Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.
Autoimmunity
2017
50:329-335
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Shupeng WU, Jing WANG, Fang LI
Role of SNF5 in rheumatoid arthritis by up-regulation of p16 and inactivation of JNK 1 pathway
Turkish Journal of Biology
2017
41: 535-542
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Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I.
Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells
Mol Med Rep
2017
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Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p
Front Immunol
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Moriya N, Shibasaki S, Karasaki M, Iwasaki T.
The Impact of MicroRNA-223-3p on IL-17 Receptor D Expression in Synovial Cells
PLoS One
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12(1):e0169702
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Tang Q, Cui J, Tian Z, Sun J, Wang Z, Chang S, Zhu S.
Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes
Int J Nanomedicine
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Hashiguchi M, Suzuki K, Kaneko K, Nagaoka I.
Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate
Mol Med Rep
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15(6):4398-4404
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Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line.
Mod Rheumatol
2016
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Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis.
Autoimmunity
2016
49:109-14
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Wu WJ, Jia WW, Liu XH, Pan LL, Zhang QY, Yang D, Shen XY, Liu L, Zhu YZ.
S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway.
Redox Biol
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Someya A, Ikegami T, Sakamoto K, Nagaoka I.
Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms.
PLoS ONE
2016
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