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Cell No. : Cell Name
RCB1512 : MH7A  update : 2023/08/02
CommentRheumatoid fibroblast-like synoviocyte transformed with SV40 T antigen. Respond to IL-1beta.
Comment from the depositor
Terms and conditions In relation to all kinds of use, it is necessary to pay license fee to the depositor. First of all, please contact the depositor.
approver's address
Kissei Pharmaceutical Co., Ltd.

4365-1 Kashihara, Hodaka, Azumino, Nagano 399-8304 Japan
Dr.R & D, Planning
Fax. +81-263-82-8826
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor R & D, Planning
Originator Miyazawa, Keiji
Year of deposit 1999
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Age at sampling 53 years
Tissue synovial
Disease name Rheumatoid Arthritis (RA)
Classification transformed
Recombinant recombinant
Exogene SV40 large T antigen
Lifespan infinite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_0427
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
Chromosome mode 66-82(50) : /73(6),74(4),75(6),76(3),77(7),78(5)/
STR(human) OK
deposit info
lot info
Reference information Reference 2
User's Publication 108

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2339  Miyazawa K, Mori A, Yamamoto K, Okudaira H  Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes.  J Biol Chem  1998  273:7620-7  PubMed ID: 9516466   DOI: 10.1074/jbc.273.13.7620
2338  Miyazawa K, Mori A, Okudaira H  Establishment and Characterization of a Novel Human Rheumatoid Fibroblast-Like Synoviocyte Line, MH7A, Immortalized with SV40 T Antigen  J Biochem  1998  124:1153-1162  PubMed ID: 9832620   DOI: 10.1093/oxfordjournals.jbchem.a022233

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User's Publication
21705  Fujii K, Iwata I, Takaya A, Ishibashi M, Hara Y.  New biflavonoids isolated from Xylia kerrii leaves extract with selective cytotoxicity against MH7A human rheumatoid arthritis synovial fibroblast cells.  J Nat Med  2024    PubMed ID: 38592349   DOI: 10.1007/s11418-024-01801-6
21723  Zihe Ding, Xiaoyue Wang, Yi Zhang, Jian Liu, Lei Wan, Tao Li, Lin Chen, Na Lin, Yanqiong Zhang  Altered Iron-Mediated Metabolic Homeostasis Governs the Efficacy and Toxicity of Tripterygium Glycosides Tablets Against Rheumatoid Arthritis  Engineering  2024      DOI: 10.1016/j.eng.2024.04.003
21724  Lin CY, Lee KT, Lin YY, Tsai CH, Ko CY, Fong YC, Hou SM, Chen WL, Huang CC, Tang CH.  NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis  Int Immunopharmacol  2024  130:111733  PubMed ID: 38387191   DOI: 10.1016/j.intimp.2024.111733
21725  Achudhan D, Lai YL, Lin YY, Huang YL, Tsai CH, Ho TL, Ko CY, Fong YC, Huang CC, Tang CH.  CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation  Biochem Pharmacol  2024  Mar:221:116037  PubMed ID: 38301965   DOI: 10.1016/j.bcp.2024.116037
17608  Ni R, Liu H, Song G, Fu X, Deng B, Xu Z, Dai S, Huang G.  MiR-216a-3p inhibits the proliferation and invasion of fibroblast-like synoviocytes by targeting dual-specificity phosphatase 5  Int J Rheum Dis  2023  26(4):699-709  PubMed ID: 36843205   DOI: 10.1111/1756-185X.14622
17771  Liu F, Zhan S, Zhang P, Jia C, Zhu Q, Dai Q, Yu M, Cheng L, Xiong L, Sun F, Xia P, Zhang X, Hu J.  Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula  Front Physiol  2023  14:1138947  PubMed ID: 36969583   DOI: 10.3389/fphys.2023.1138947
19563  Chang JW, Liu SC, Lin YY, He XY, Wu YS, Su CM, Tsai CH, Chen HT, Fong YC, Hu SL, Huang CC, Tang CH.  Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy  Int J Biol Sci  2023  19(1):281-293  PubMed ID: 36594093   DOI: 10.7150/ijbs.77987
21328  Chang JW, Lin YY, Tsai CH, Liu SC, He XY, Wu YS, Huang CC, Tang CH.  Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis.  Biochem Pharmacol  2023  115687  PubMed ID: 37481139   DOI: 10.1016/j.bcp.2023.115687
21495  Mao X, Yan X, Li C, Liu Y, Zhang Y, Lin N.  Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis.  Chin Med  2023  18(1):156  PubMed ID: 38037139   DOI: 10.1186/s13020-023-00863-0
21519  Jiang Y, Zhong S, Tan H, Fu Y, Lai J, Liu L, Weng J, Chen H, He S.  Study on the mechanism of action of Saposhnikovia divaricata and its key phytochemical on rheumatoid arthritis based on network pharmacology and bioinformatics.  J Ethnopharmacol  2023  117586  PubMed ID: 38104871   DOI: 10.1016/j.jep.2023.117586
17636  Mokuda S, Watanabe H, Kohno H, Ishitoku M, Araki K, Hirata S, Sugiyama E.  N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes  Cytotechnology   2022  74(4):503-514  PubMed ID: 35791402   DOI: 10.1007/s10616-022-00540-4
20557  Lin X, Tao C, Zhang R, Zhang M, Wang Q, Chen J.  N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes.  Phytomedicine  2022  95:153871  PubMed ID: 34902811   DOI: 10.1016/j.phymed.2021.153871
20626  Li L, Zhan M, Li M.  Circular RNA circ_0130438 suppresses TNF-α-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis.  Transpl Immunol  2022  101588  PubMed ID: 35358709   DOI: 10.1016/j.trim.2022.101588
16620  David Achudhan, Sunny Li-Yun Chang, Shan-Chi Liu, Yen-You Lin, Wei-Chien Huang, Yang-Chang Wu, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, Yueh-Hsiung Kuo, Chih-Hsin Tang  Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts  Food & Nutrition Research  2022  66  PubMed ID: 35783555   DOI: 10.29219/fnr.v66.8645
16745  Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q, Su X, Yan S, Su W, Zhang Y, Lin N.  A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis  Front Immunol  2022  13:912933  PubMed ID: 35799788   DOI: 10.3389/fimmu.2022.912933
16922  Fu M, Sang X, Cheng H.  Total glucosides of peony induce fibroblast-like synovial apoptosis, and ameliorate cartilage injury via blocking the NF-κB/STAT3 pathway  Ann Transl Med  2022  10(2):51  PubMed ID: 35282135   DOI: 10.21037/atm-21-6187
16987  Konishi H, Kanou SE, Yukimatsu R, Inui M, Sato M, Yamamoto N, Nakano M, Koshiba M.  Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A 2A receptor signaling  Sci Rep  2022  12(1):6033  PubMed ID: 35410356   DOI: 10.1038/s41598-022-10012-6
16999  Sueda Y, Okazaki R, Funaki Y, Hasegawa Y, Ishikawa H, Hirayama Y, Inui G, Harada T, Takata M, Morita M, Yamasaki A.  Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts  Yonago Acta Med  2022  65(2):111-125  PubMed ID: 35611061   DOI: 10.33160/yam.2022.05.001
17000  Sun X, Li KX, Figueiredo ML, Lin CC, Li BY, Yokota H.  Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling  Cancers (Basel)  2022  14(13):3039  PubMed ID: 35804814   DOI: 10.3390/cancers14133039
20977  Yu B, Chen Y, Chen E, Zuo F, Yuan Y, Zhao X, Xiao C.  LncRNA RNA XIST binding to GATA1 contributes to rheumatoid arthritis through its effects on proliferation of synovial fibroblasts and angiogenesis via regulation of CCN6.  Mol Immunol  2022  153:200-211  PubMed ID: 36542956   DOI: 10.1016/j.molimm.2022.12.004
21031  Xu L, Niu X, Liu Y, Liu L.  ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway.  Mediators Inflamm  2022  2022:4258742  PubMed ID: 36405992   DOI: 10.1155/2022/4258742
21659  Achudhan D, Liu SC, Lin YY, Lee HP, Wang SW, Huang WC, Wu YC, Kuo YH, Tang CH.  Antcin K inhibits VEGF-dependent angiogenesis in human rheumatoid arthritis synovial fibroblasts  J Food Biochem  2022  46(1):e14022  PubMed ID: 34841538   DOI: 10.1111/jfbc.14022
13169  Fu X, Song G, Ni R, Liu H, Xu Z, Zhang D, He F, Huang G.  LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a.  Rheumatology (Oxford)  2021    PubMed ID: 32810279   DOI: 10.1093/rheumatology/keaa395
14180  Gan D, Cheng W, Ke L, Sun AR, Jia Q, Chen J, Lin J, Li J, Xu Z, Zhang P.  Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis  Front Pharmacol  2021  12:631891  PubMed ID: 33746759   DOI: 10.3389/fphar.2021.631891
14833  Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N.  Metformin repositioning in rheumatoid arthritis  Clin Exp Rheumatol  2021  39(4):763-768  PubMed ID: 32828146   DOI: 10.55563/clinexprheumatol/zn2u9h
20292  Chen J, Li J, Chen J, Cheng W, Lin J, Ke L, Liu G, Bai X, Zhang P.  Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor.  J Orthop Translat  2021  28:100-107  PubMed ID: 33816113   DOI: 10.1016/
20295  Kaihara K, Nakagawa S, Arai Y, Inoue H, Tsuchida S, Fujii Y, Kamada Y, Kishida T, Mazda O, Takahashi K.  Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α.  Int J Mol Sci  2021  22(8)  PubMed ID: 33918929   DOI: 10.3390/ijms22083898
15287  Yoon SS, Moon EY.  B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor  Int J Mol Sci  2021  22(13):7166  PubMed ID: 34281218   DOI: 10.3390/ijms22137166
15291  Matsumoto M, Liu J, Iwata K, Ibi M, Asaoka N, Zhang X, Katsuyama M, Matsuda M, Nabe T, Schröder K, Yabe-Nishimura C.  NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis  J Pharmacol Sci  2021  146(2):88-97  PubMed ID: 33941325   DOI: 10.1016/j.jphs.2021.01.009
20446  Mijiti N, Someya A, Nagaoka I.  Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells.  Exp Ther Med  2021  22(5):1300  PubMed ID: 34630655   DOI: 10.3892/etm.2021.10735
16272  Li C, Pan J, Xu C, Jin Z, Chen X.  A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking  Front Cell Dev Biol  2021  9:740266  PubMed ID: 35127697   DOI: 10.3389/fcell.2021.740266
16277  Chang TK, Zhong YH, Liu SC, Huang CC, Tsai CH, Lee HP, Wang SW, Hsu CJ, Tang CH.  Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway  Front Immunol  2021  12:737990  PubMed ID: 34659230   DOI: 10.3389/fimmu.2021.737990
16278  Achudhan D, Liu SC, Lin YY, Huang CC, Tsai CH, Ko CY, Chiang IP, Kuo YH, Tang CH.  Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis  Front Immunol  2021  12:790925  PubMed ID: 34975889   DOI: 10.3389/fimmu.2021.790925
16929  Lin J, Sun AR, Li J, Yuan T, Cheng W, Ke L, Chen J, Sun W, Mi S, Zhang P.  A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue  Front Bioeng Biotechnol  2021  9:764212  PubMed ID: 34869276   DOI: 10.3389/fbioe.2021.764212
16980  Chen X, Lin H, Chen J, Wu L, Zhu J, Ye Y, Chen S, Du H, Li J.  Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis  Front Pharmacol  2021  12:714566  PubMed ID: 34566640   DOI: 10.3389/fphar.2021.714566
16983  Law YY, Lee WF, Hsu CJ, Lin YY, Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF.  miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts  Aging (Albany NY)  2021  13(13):17227-17236  PubMed ID: 34198264   DOI: 10.18632/aging.203201
16991  Ba X, Huang Y, Shen P, Huang Y, Wang H, Han L, Lin WJ, Yan HJ, Xu LJ, Qin K, Chen Z, Tu SH.  WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway  Front Pharmacol  2021  12:696802  PubMed ID: 34646130   DOI: 10.3389/fphar.2021.696802
16995  Huang CC, Law YY, Liu SC, Hu SL, Lin JA, Chen CJ, Wang SW, Tang CH.  Adiponectin Promotes VEGF Expression in Rheumatoid Arthritis Synovial Fibroblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-106a-5p  Cells  2021  10(10):2627  PubMed ID: 34685605   DOI: 10.3390/cells10102627
17083  Han CK, Lee WF, Hsu CJ, Huang YL, Lin CY, Tsai CH, Huang CC, Fong YC, Wu MH, Liu JF, Tang CH.  DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts  J Cell Physiol  2021  236(12):8060-8069  PubMed ID: 34192347   DOI: 10.1002/jcp.30494
13031  Yamagishi Y, Someya A, Nagaoka I.  Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine.  Biomed Rep  2020    PubMed ID: 32440348   DOI: 10.3892/br.2020.1304
13058  Tsai MH, Chi MC, Hsu JF, Lee IT, Lin KM, Fang ML, Lee MH, Lee CW, Liu JF.  Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis.  Cells  2020    PubMed ID: 32498294   DOI: 10.3390/cells9061378
13149  Lee J, Yoon SS, Thuy PX, Moon EY.  Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426.  Biomol Ther (Seoul)  2020    PubMed ID: 32753567   DOI: 10.4062/biomolther.2020.110
13503  Wu H, He Y, Wu H, Zhou M, Xu Z, Xiong R, Yan F, Liu H.  Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes  Theranostics  2020  10(22):10092-10105  PubMed ID: 32929336   DOI: 10.7150/thno.44865
13519  Wu S, Wang J, Li J, Li F.  microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5  Inflammation  2020  43(2):441-454  PubMed ID: 32008163   DOI: 10.1007/s10753-019-01117-8
13540  Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS.  PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis  Biomol Ther (Seoul)  2020  28(2):172-183  PubMed ID: 31739383   DOI: 10.4062/biomolther.2019.153
13563  Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q.  Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model  Front Pharmacol  2020  11:45  PubMed ID: 32116720   DOI: 10.3389/fphar.2020.00045
13644  Hsiang-Ping Lee, Yang-Chang Wu, Bo-Cheng Chen, Shan-Chi Liu, Te-Mao Li, Wei-Chien Huang, Chin-Jung Hsu, Chih-Hsin Tang  Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways  Food and Agricultural Immunology  2020  21(740-750)    DOI: 10.1080/09540105.2020.1766426
13645  Kanai T, Kondo N, Okada M, Sano H, Okumura G, Kijima Y, Ogose A, Kawashima H, Endo N.  The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3  J Orthop Surg Res  2020  15(1):87  PubMed ID: 32131874   DOI: 10.1186/s13018-020-01595-9
14843  Cheng WX, Zhong S, Meng XB, Zheng NY, Zhang P, Wang Y, Qin L, Wang XL  Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats  J Pharmacol Exp Ther  2020  373(2):302-310  PubMed ID: 32029577   DOI: 10.1124/jpet.119.262907
14852  Benjamin Yüksel, Klaus Schwarz, Reiner Creutzburg  AI-based anomaly detection for cyberattacks on Windows systems - Creation of a prototype for automated monitoring of the process environment  Electronic Imaging  2020  331-1-331-13    DOI: 10.2352/issn.2470-1173.2020.3.mobmu-304
14856  Liu C, He L, Wang J, Wang Q, Sun C, Li Y, Jia K, Wang J, Xu T, Ming R, Wang Q, Lin N.  Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways  J Ethnopharmacol  2020  260:113039  PubMed ID: 32497675   DOI: 10.1016/j.jep.2020.113039
16989  Meng X, Cheng W, Zhong S, Zhang P, Qin L, Wang X.  Anti-inflammatory effects of Jingshu Keli capsule and its components on human synoviocyte MH7A cells  Arthroplasty  2020  2(1):7  PubMed ID: 35236422   DOI: 10.1186/s42836-020-00026-8
17001  Zhang Y, Wang X, Li W, Wang H, Yin X, Jiang F, Su X, Chen W, Li T, Mao X, Guo M, Jiang Q, Lin N.  Inferences of individual differences in response to tripterysium glycosides across patients with Rheumatoid arthritis using a novel ceRNA regulatory axis  Clin Transl Med  2020  10(6):e185  PubMed ID: 33135351   DOI: 10.1002/ctm2.185
11298  Ma J, Wang X, Lv T, Liu J, Ren Y, Zhang J, Zhang Y.  Effects of Ghrelin on the Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocyte MH7A Cells.  Biol. Pharm. Bull.  2019    PubMed ID: 30429411   DOI: 10.1248/bpb.b18-00285
11434  Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I.  MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling.  Int J Mol Sci  2019    PubMed ID: 30769772   DOI: 10.3390/ijms20040809
11529  Meng D, Li J, Li H, Wang K.  Salvianolic acid B remits LPS-induced injury by up-regulating miR-142-3p in MH7A cells.  Biomed. Pharmacother.  2019    PubMed ID: 31022596   DOI: 10.1016/j.biopha.2019.108876
11688  Wen-Xiang Cheng, Huan Huang, Jian-Hai Chen, Tian-Tian Zhang, Guo-Yuan Zhu, Zheng-Tan Zheng, Jie-Tao Lin, Yi-Ping Hu, Yong Zhang, Xue-Ling Bai, Yan Wang, Zhan-Wang Xu, Bing Song, Yi-Ying Mao, Fei Yang, Peng Zhang  Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway  Journal of Orthopaedic Translation  2019    PubMed ID: 32440504   DOI: 10.1016/
12330  Jia Q, Wang T, Wang X, Xu H, Liu Y, Wang Y, Shi Q, Liang Q.  Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes  Front Pharmacol  2019  10:94  PubMed ID: 30809149   DOI: 10.3389/fphar.2019.00094
12519  Chen H, Liang Q, Zhou X, Wang X.  Preparative separation of the flavonoid fractions from Periploca forrestii Schltr. ethanol extracts using macroporous resin combined with HPLC analysis and evaluation of their biological activities  J Sep Sci  2019  42(3):650-661  PubMed ID: 30461196   DOI: 10.1002/jssc.201800422
12520  Huang CC, Chiou CH, Liu SC, Hu SL, Su CM, Tsai CH, Tang CH.  Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis  J Pineal Res  2019  66(3):e12560  PubMed ID: 30648758   DOI: 10.1111/jpi.12560
10840  Jia W, Wu W, Yang D, Xiao C, Huang M, Long F, Su Z, Qin M, Liu X, Zhu YZ.  GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis.  Cell Death Dis  2018  9:503  PubMed ID: 29717129   DOI: 10.1038/s41419-018-0570-5
11091  Takeno M, Kitagawa S, Yamanaka J, Teramoto M, Tomita H, Shirai N, Itoh S, Hida S, Hayakawa K, Onozaki K, Takii T.  5-Hydroxy-2-methylpyridine Isolated from Cigarette Smoke Condensate Aggravates Collagen-Induced Arthritis in Mice.  Biol. Pharm. Bull.  2018  41(6):877-884  PubMed ID: 29863076   DOI: 10.1248/bpb.b17-00982
11169  Wang X, Wang X, Sun J, Fu S.  An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome-protamine-DNA-siRNA complex with cell permeable peptides.  Int. J. Mol. Med.  2018  42(5):2393-2402  PubMed ID: 30106091   DOI: 10.3892/ijmm.2018.3815
11203  Zhong F, Xu J, Yang X, Zhang Q, Gao Z, Deng Y, Zhang L, Yu C.  miR-145 eliminates lipopolysaccharides-induced inflammatory injury in human fibroblast-like synoviocyte MH7A cells.  J. Cell. Biochem.  2018    PubMed ID: 30191608   DOI: 10.1002/jcb.27341
4296  He L, Liu C, Sun C, Wang J, Zhi K, Sun D, Wang H, Wang Q, Lin N.  Wu-Tou Decoction Inhibits Angiogenesis in Experimental Arthritis by Targeting VEGFR2 Signaling Pathway.  Rejuvenation Res  2018    PubMed ID: 29385909   DOI: 10.1089/rej.2017.2011
4297  Wu J, Fan W, Ma L, Geng X.  miR-708-5p promotes fibroblast-like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway.  Drug Des Devel Ther  2018    PubMed ID: 30349197   DOI: 10.2147/DDDT.S177128
14551  Takamura Y, Aoki W, Satomura A, Shibasaki S, Ueda M.  Small RNAs detected in exosomes derived from the MH7A synovial fibroblast cell line with TNF-α stimulation  PLoS One  2018  13(8):e0201851  PubMed ID: 30096164   DOI: 10.1371/journal.pone.0201851
14904  Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY.  Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis  Cell Death Dis  2018  9(3):401  PubMed ID: 29540697   DOI: 10.1038/s41419-018-0433-0
10252  Lee JW, Lee J, Um SH, Moon EY.  Synovial cell death is regulated by TNF-α-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1α.  Cell Death Dis  2017  8:e2727  PubMed ID: 28383556   DOI: 10.1038/cddis.2017.26
10404  Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N.  Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.  Autoimmunity  2017  50:329-335  PubMed ID: 28682648   DOI: 10.1080/08916934.2017.1344970
10932  Shupeng WU, Jing WANG, Fang LI  Role of SNF5 in rheumatoid arthritis by up-regulation of p16 and inactivation of JNK 1 pathway  Turkish Journal of Biology  2017  41: 535-542    DOI: 10.3906/biy-1610-40
14250  Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I.  Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells  Mol Med Rep  2017  16(2):1353-1359  PubMed ID: 28586015   DOI: 10.3892/mmr.2017.6691
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9879  Someya A, Ikegami T, Sakamoto K, Nagaoka I.  Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms.  PLoS ONE  2016  11:e0165158  PubMed ID: 27776166   DOI: 10.1371/journal.pone.0165158
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