CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1512 : MH7A]

2339 Miyazawa K, Mori A, Yamamoto K, Okudaira H Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes. J Biol Chem 1998 273:7620-7 PubMed ID: 9516466 DOI: 10.1074/jbc.273.13.7620

2338 Miyazawa K, Mori A, Okudaira H Establishment and Characterization of a Novel Human Rheumatoid Fibroblast-Like Synoviocyte Line, MH7A, Immortalized with SV40 T Antigen J Biochem 1998 124:1153-1162 PubMed ID: 9832620 DOI: 10.1093/oxfordjournals.jbchem.a022233

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20557 Lin X, Tao C, Zhang R, Zhang M, Wang Q, Chen J. N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes. Phytomedicine 2022 95:153871 PubMed ID: 34902811 DOI: 10.1016/j.phymed.2021.153871

20626 Li L, Zhan M, Li M. Circular RNA circ_0130438 suppresses TNF-α-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis. Transpl Immunol 2022 101588 PubMed ID: 35358709 DOI: 10.1016/j.trim.2022.101588

16620 David Achudhan, Sunny Li-Yun Chang, Shan-Chi Liu, Yen-You Lin, Wei-Chien Huang, Yang-Chang Wu, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, Yueh-Hsiung Kuo, Chih-Hsin Tang Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts Food & Nutrition Research 2022 66 DOI: 10.29219/fnr.v66.8645

16745 Li W, Wang K, Liu Y, Wu H, He Y, Li C, Wang Q, Su X, Yan S, Su W, Zhang Y, Lin N. A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis Front Immunol 2022 13:912933 PubMed ID: 35799788 DOI: 10.3389/fimmu.2022.912933

16922 Fu M, Sang X, Cheng H. Total glucosides of peony induce fibroblast-like synovial apoptosis, and ameliorate cartilage injury via blocking the NF-κB/STAT3 pathway Ann Transl Med 2022 10(2):51 PubMed ID: 35282135 DOI: 10.21037/atm-21-6187

16987 Konishi H, Kanou SE, Yukimatsu R, Inui M, Sato M, Yamamoto N, Nakano M, Koshiba M. Adenosine inhibits TNFα-induced MMP-3 production in MH7A rheumatoid arthritis synoviocytes via A 2A receptor signaling Sci Rep 2022 12(1):6033 PubMed ID: 35410356 DOI: 10.1038/s41598-022-10012-6

16999 Sueda Y, Okazaki R, Funaki Y, Hasegawa Y, Ishikawa H, Hirayama Y, Inui G, Harada T, Takata M, Morita M, Yamasaki A. Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts Yonago Acta Med 2022 65(2):111-125 PubMed ID: 35611061 DOI: 10.33160/yam.2022.05.001

17000 Sun X, Li KX, Figueiredo ML, Lin CC, Li BY, Yokota H. Generation of the Chondroprotective Proteomes by Activating PI3K and TNFα Signaling Cancers (Basel) 2022 14(13):3039 PubMed ID: 35804814 DOI: 10.3390/cancers14133039

13169 Fu X, Song G, Ni R, Liu H, Xu Z, Zhang D, He F, Huang G. LncRNA-H19 silencing suppresses synoviocytes proliferation and attenuates collagen-induced arthritis progression by modulating miR-124a. Rheumatology (Oxford) 2021 PubMed ID: 32810279 DOI: 10.1093/rheumatology/keaa395

14180 Gan D, Cheng W, Ke L, Sun AR, Jia Q, Chen J, Lin J, Li J, Xu Z, Zhang P. Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis Front Pharmacol 2021 12:631891 PubMed ID: 33746759 DOI: 10.3389/fphar.2021.631891

14833 Matsuoka Y, Morimoto S, Fujishiro M, Hayakawa K, Kataoka Y, Suzuki S, Ikeda K, Takamori K, Yamaji K, Tamura N. Metformin repositioning in rheumatoid arthritis Clin Exp Rheumatol 2021 39(4):763-768 PubMed ID: 32828146

20292 Chen J, Li J, Chen J, Cheng W, Lin J, Ke L, Liu G, Bai X, Zhang P. Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor. J Orthop Translat 2021 28:100-107 PubMed ID: 33816113 DOI: 10.1016/j.jot.2021.01.003

20295 Kaihara K, Nakagawa S, Arai Y, Inoue H, Tsuchida S, Fujii Y, Kamada Y, Kishida T, Mazda O, Takahashi K. Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α. Int J Mol Sci 2021 22(8) PubMed ID: 33918929 DOI: 10.3390/ijms22083898

15287 Yoon SS, Moon EY. B Cell Adhesion to Fibroblast-Like Synoviocytes Is Up-Regulated by Tumor Necrosis Factor-Alpha via Expression of Human Vascular Cell Adhesion Molecule-1 Mediated by B Cell-Activating Factor Int J Mol Sci 2021 22(13):7166 PubMed ID: 34281218 DOI: 10.3390/ijms22137166

15291 Matsumoto M, Liu J, Iwata K, Ibi M, Asaoka N, Zhang X, Katsuyama M, Matsuda M, Nabe T, Schröder K, Yabe-Nishimura C. NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis J Pharmacol Sci 2021 146(2):88-97 PubMed ID: 33941325 DOI: 10.1016/j.jphs.2021.01.009

20446 Mijiti N, Someya A, Nagaoka I. Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells. Exp Ther Med 2021 22(5):1300 PubMed ID: 34630655 DOI: 10.3892/etm.2021.10735

16272 Li C, Pan J, Xu C, Jin Z, Chen X. A Preliminary Inquiry Into the Potential Mechanism of Huang-Lian-Jie-Du Decoction in Treating Rheumatoid Arthritis via Network Pharmacology and Molecular Docking Front Cell Dev Biol 2021 9:740266 PubMed ID: 35127697 DOI: 10.3389/fcell.2021.740266

16277 Chang TK, Zhong YH, Liu SC, Huang CC, Tsai CH, Lee HP, Wang SW, Hsu CJ, Tang CH. Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway Front Immunol 2021 12:737990 PubMed ID: 34659230 DOI: 10.3389/fimmu.2021.737990

16278 Achudhan D, Liu SC, Lin YY, Huang CC, Tsai CH, Ko CY, Chiang IP, Kuo YH, Tang CH. Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis Front Immunol 2021 12:790925 PubMed ID: 34975889 DOI: 10.3389/fimmu.2021.790925

16929 Lin J, Sun AR, Li J, Yuan T, Cheng W, Ke L, Chen J, Sun W, Mi S, Zhang P. A Three-Dimensional Co-Culture Model for Rheumatoid Arthritis Pannus Tissue Front Bioeng Biotechnol 2021 9:764212 PubMed ID: 34869276 DOI: 10.3389/fbioe.2021.764212

16980 Chen X, Lin H, Chen J, Wu L, Zhu J, Ye Y, Chen S, Du H, Li J. Paclitaxel Inhibits Synoviocyte Migration and Inflammatory Mediator Production in Rheumatoid Arthritis Front Pharmacol 2021 12:714566 PubMed ID: 34566640 DOI: 10.3389/fphar.2021.714566

16991 Ba X, Huang Y, Shen P, Huang Y, Wang H, Han L, Lin WJ, Yan HJ, Xu LJ, Qin K, Chen Z, Tu SH. WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway Front Pharmacol 2021 12:696802 PubMed ID: 34646130 DOI: 10.3389/fphar.2021.696802

16995 Huang CC, Law YY, Liu SC, Hu SL, Lin JA, Chen CJ, Wang SW, Tang CH. Adiponectin Promotes VEGF Expression in Rheumatoid Arthritis Synovial Fibroblasts and Induces Endothelial Progenitor Cell Angiogenesis by Inhibiting miR-106a-5p Cells 2021 10(10):2627 PubMed ID: 34685605 DOI: 10.3390/cells10102627

17083 Han CK, Lee WF, Hsu CJ, Huang YL, Lin CY, Tsai CH, Huang CC, Fong YC, Wu MH, Liu JF, Tang CH. DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts J Cell Physiol 2021 236(12):8060-8069 PubMed ID: 34192347 DOI: 10.1002/jcp.30494

13031 Yamagishi Y, Someya A, Nagaoka I. Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine. Biomed Rep 2020 PubMed ID: 32440348 DOI: 10.3892/br.2020.1304

13058 Tsai MH, Chi MC, Hsu JF, Lee IT, Lin KM, Fang ML, Lee MH, Lee CW, Liu JF. Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis. Cells 2020 PubMed ID: 32498294 DOI: 10.3390/cells9061378

13149 Lee J, Yoon SS, Thuy PX, Moon EY. Synovial Cell Migration is Associated with B Cell Activating Factor Expression Increased by TNFα or Decreased by KR33426. Biomol Ther (Seoul) 2020 PubMed ID: 32753567 DOI: 10.4062/biomolther.2020.110

13503 Wu H, He Y, Wu H, Zhou M, Xu Z, Xiong R, Yan F, Liu H. Near-infrared fluorescence imaging-guided focused ultrasound-mediated therapy against Rheumatoid Arthritis by MTX-ICG-loaded iRGD-modified echogenic liposomes Theranostics 2020 10(22):10092-10105 PubMed ID: 32929336 DOI: 10.7150/thno.44865

13519 Wu S, Wang J, Li J, Li F. microRNA-21 Aggravates Lipopolysaccharide-Induced Inflammation in MH7A Cells Through Targeting SNF5 Inflammation 2020 43(2):441-454 PubMed ID: 32008163 DOI: 10.1007/s10753-019-01117-8

13540 Kim J, Jung KH, Yoo J, Park JH, Yan HH, Fang Z, Lim JH, Kwon SR, Kim MK, Park HJ, Hong SS. PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis Biomol Ther (Seoul) 2020 28(2):172-183 PubMed ID: 31739383 DOI: 10.4062/biomolther.2019.153

13563 Wang T, Jia Q, Chen T, Yin H, Tian X, Lin X, Liu Y, Zhao Y, Wang Y, Shi Q, Huang C, Xu H, Liang Q. Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model Front Pharmacol 2020 11:45 PubMed ID: 32116720 DOI: 10.3389/fphar.2020.00045

13644 Hsiang-Ping Lee, Yang-Chang Wu, Bo-Cheng Chen, Shan-Chi Liu, Te-Mao Li, Wei-Chien Huang, Chin-Jung Hsu, Chih-Hsin Tang Soya-cerebroside reduces interleukin production in human rheumatoid arthritis synovial fibroblasts by inhibiting the ERK, NF-κB and AP-1 signalling pathways Food and Agricultural Immunology 2020 21(740-750) DOI: 10.1080/09540105.2020.1766426

13645 Kanai T, Kondo N, Okada M, Sano H, Okumura G, Kijima Y, Ogose A, Kawashima H, Endo N. The JNK pathway represents a novel target in the treatment of rheumatoid arthritis through the suppression of MMP-3 J Orthop Surg Res 2020 15(1):87 PubMed ID: 32131874 DOI: 10.1186/s13018-020-01595-9

14843 Cheng WX, Zhong S, Meng XB, Zheng NY, Zhang P, Wang Y, Qin L, Wang XL Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats J Pharmacol Exp Ther 2020 373(2):302-310 PubMed ID: 32029577 DOI: 10.1124/jpet.119.262907

14852 Benjamin Yüksel, Klaus Schwarz, Reiner Creutzburg AI-based anomaly detection for cyberattacks on Windows systems - Creation of a prototype for automated monitoring of the process environment Electronic Imaging 2020 331-1-331-13 DOI: 10.2352/issn.2470-1173.2020.3.mobmu-304

14856 Liu C, He L, Wang J, Wang Q, Sun C, Li Y, Jia K, Wang J, Xu T, Ming R, Wang Q, Lin N. Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways J Ethnopharmacol 2020 260:113039 PubMed ID: 32497675 DOI: 10.1016/j.jep.2020.113039

16989 Meng X, Cheng W, Zhong S, Zhang P, Qin L, Wang X. Anti-inflammatory effects of Jingshu Keli capsule and its components on human synoviocyte MH7A cells Arthroplasty 2020 2(1):7 PubMed ID: 35236422 DOI: 10.1186/s42836-020-00026-8

17001 Zhang Y, Wang X, Li W, Wang H, Yin X, Jiang F, Su X, Chen W, Li T, Mao X, Guo M, Jiang Q, Lin N. Inferences of individual differences in response to tripterysium glycosides across patients with Rheumatoid arthritis using a novel ceRNA regulatory axis Clin Transl Med 2020 10(6):e185 PubMed ID: 33135351 DOI: 10.1002/ctm2.185

11298 Ma J, Wang X, Lv T, Liu J, Ren Y, Zhang J, Zhang Y. Effects of Ghrelin on the Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocyte MH7A Cells. Biol. Pharm. Bull. 2019 PubMed ID: 30429411 DOI: 10.1248/bpb.b18-00285

11434 Hayakawa K, Kawasaki M, Hirai T, Yoshida Y, Tsushima H, Fujishiro M, Ikeda K, Morimoto S, Takamori K, Sekigawa I. MicroRNA-766-3p Contributes to Anti-Inflammatory Responses through the Indirect Inhibition of NF-κB Signaling. Int J Mol Sci 2019 PubMed ID: 30769772 DOI: 10.3390/ijms20040809

11529 Meng D, Li J, Li H, Wang K. Salvianolic acid B remits LPS-induced injury by up-regulating miR-142-3p in MH7A cells. Biomed. Pharmacother. 2019 PubMed ID: 31022596 DOI: 10.1016/j.biopha.2019.108876

11688 Wen-Xiang Cheng, Huan Huang, Jian-Hai Chen, Tian-Tian Zhang, Guo-Yuan Zhu, Zheng-Tan Zheng, Jie-Tao Lin, Yi-Ping Hu, Yong Zhang, Xue-Ling Bai, Yan Wang, Zhan-Wang Xu, Bing Song, Yi-Ying Mao, Fei Yang, Peng Zhang Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway Journal of Orthopaedic Translation 2019 PubMed ID: 32440504 DOI: 10.1016/j.jot.2019.07.007

12330 Jia Q, Wang T, Wang X, Xu H, Liu Y, Wang Y, Shi Q, Liang Q. Astragalin Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis and in Human Fibroblast-Like Synoviocytes Front Pharmacol 2019 10:94 PubMed ID: 30809149 DOI: 10.3389/fphar.2019.00094

12519 Chen H, Liang Q, Zhou X, Wang X. Preparative separation of the flavonoid fractions from Periploca forrestii Schltr. ethanol extracts using macroporous resin combined with HPLC analysis and evaluation of their biological activities J Sep Sci 2019 42(3):650-661 PubMed ID: 30461196 DOI: 10.1002/jssc.201800422

12520 Huang CC, Chiou CH, Liu SC, Hu SL, Su CM, Tsai CH, Tang CH. Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis J Pineal Res 2019 66(3):e12560 PubMed ID: 30648758 DOI: 10.1111/jpi.12560

17002 Ge H, Liu J, Liu F, Sun Y, Yang R. Long non-coding RNA ROR mitigates cobalt chloride-induced hypoxia injury through regulation of miR-145 Artif Cells Nanomed Biotechnol 2019 47(1):2221-2229 PubMed ID: 31164009 DOI: 10.1080/21691401.2019.1620759

10840 Jia W, Wu W, Yang D, Xiao C, Huang M, Long F, Su Z, Qin M, Liu X, Zhu YZ. GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis. Cell Death Dis 2018 9:503 PubMed ID: 29717129 DOI: 10.1038/s41419-018-0570-5

11091 Takeno M, Kitagawa S, Yamanaka J, Teramoto M, Tomita H, Shirai N, Itoh S, Hida S, Hayakawa K, Onozaki K, Takii T. 5-Hydroxy-2-methylpyridine Isolated from Cigarette Smoke Condensate Aggravates Collagen-Induced Arthritis in Mice. Biol. Pharm. Bull. 2018 41(6):877-884 PubMed ID: 29863076 DOI: 10.1248/bpb.b17-00982

11169 Wang X, Wang X, Sun J, Fu S. An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome-protamine-DNA-siRNA complex with cell permeable peptides. Int. J. Mol. Med. 2018 42(5):2393-2402 PubMed ID: 30106091 DOI: 10.3892/ijmm.2018.3815

11203 Zhong F, Xu J, Yang X, Zhang Q, Gao Z, Deng Y, Zhang L, Yu C. miR-145 eliminates lipopolysaccharides-induced inflammatory injury in human fibroblast-like synoviocyte MH7A cells. J. Cell. Biochem. 2018 PubMed ID: 30191608 DOI: 10.1002/jcb.27341

4296 He L, Liu C, Sun C, Wang J, Zhi K, Sun D, Wang H, Wang Q, Lin N. Wu-Tou Decoction Inhibits Angiogenesis in Experimental Arthritis by Targeting VEGFR2 Signaling Pathway. Rejuvenation Res 2018 PubMed ID: 29385909 DOI: 10.1089/rej.2017.2011

4297 Wu J, Fan W, Ma L, Geng X. miR-708-5p promotes fibroblast-like synoviocytes' cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway. Drug Des Devel Ther 2018 PubMed ID: 30349197 DOI: 10.2147/DDDT.S177128

14551 Takamura Y, Aoki W, Satomura A, Shibasaki S, Ueda M. Small RNAs detected in exosomes derived from the MH7A synovial fibroblast cell line with TNF-α stimulation PLoS One 2018 13(8):e0201851 PubMed ID: 30096164 DOI: 10.1371/journal.pone.0201851

14904 Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY. Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis Cell Death Dis 2018 9(3):401 PubMed ID: 29540697 DOI: 10.1038/s41419-018-0433-0

10252 Lee JW, Lee J, Um SH, Moon EY. Synovial cell death is regulated by TNF-α-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1α. Cell Death Dis 2017 8:e2727 PubMed ID: 28383556 DOI: 10.1038/cddis.2017.26

10404 Tsushima H, Morimoto S, Fujishiro M, Yoshida Y, Hayakawa K, Hirai T, Miyashita T, Ikeda K, Yamaji K, Takamori K, Takasaki Y, Sekigawa I, Tamura N. Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis. Autoimmunity 2017 50:329-335 PubMed ID: 28682648 DOI: 10.1080/08916934.2017.1344970

10932 Shupeng WU, Jing WANG, Fang LI Role of SNF5 in rheumatoid arthritis by up-regulation of p16 and inactivation of JNK 1 pathway Turkish Journal of Biology 2017 41: 535-542 DOI: 10.3906/biy-1610-40

14250 Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I. Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells Mol Med Rep 2017 16(2):1353-1359 PubMed ID: 28586015 DOI: 10.3892/mmr.2017.6691

14451 Hu SL, Chang AC, Huang CC, Tsai CH, Lin CC, Tang CH. Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p Front Immunol 2017 8:1747 PubMed ID: 29276516 DOI: 10.3389/fimmu.2017.01747

14486 Moriya N, Shibasaki S, Karasaki M, Iwasaki T. The Impact of MicroRNA-223-3p on IL-17 Receptor D Expression in Synovial Cells PLoS One 2017 12(1):e0169702 PubMed ID: 28056105 DOI: 10.1371/journal.pone.0169702

14590 Tang Q, Cui J, Tian Z, Sun J, Wang Z, Chang S, Zhu S. Oxygen and indocyanine green loaded phase-transition nanoparticle-mediated photo-sonodynamic cytotoxic effects on rheumatoid arthritis fibroblast-like synoviocytes Int J Nanomedicine 2017 12:381-393 PubMed ID: 28123298 DOI: 10.2147/IJN.S120902

14625 Hashiguchi M, Suzuki K, Kaneko K, Nagaoka I. Effect of aloe‑emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate Mol Med Rep 2017 15(6):4398-4404 PubMed ID: 28487948 DOI: 10.3892/mmr.2017.6541

7143 Imamura H, Yoshina S, Ikari K, Miyazawa K, Momohara S, Mitani S. Impaired NFKBIE gene function decreases cellular uptake of methotrexate by down-regulating SLC19A1 expression in a human rheumatoid arthritis cell line. Mod Rheumatol 2016 26:507-16 PubMed ID: 26587663 DOI: 10.3109/14397595.2015.1112481

7144 Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis. Autoimmunity 2016 49:109-14 PubMed ID: 26584911 DOI: 10.3109/08916934.2015.1113405

9866 Wu WJ, Jia WW, Liu XH, Pan LL, Zhang QY, Yang D, Shen XY, Liu L, Zhu YZ. S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway. Redox Biol 2016 10:157-167 PubMed ID: 27744121 DOI: 10.1016/j.redox.2016.08.011

9879 Someya A, Ikegami T, Sakamoto K, Nagaoka I. Glucosamine Downregulates the IL-1β-Induced Expression of Proinflammatory Cytokine Genes in Human Synovial MH7A Cells by O-GlcNAc Modification-Dependent and -Independent Mechanisms. PLoS ONE 2016 11:e0165158 PubMed ID: 27776166 DOI: 10.1371/journal.pone.0165158

9157 Seiji Shibasaki, Miki Karasaki, Shunsuke Aburaya, Hironobu Morisaka, Yumiko Takeda, Wataru Aoki, Sachie Kitano, Masayasu Kitano, Mitsuyoshi Ueda, Hajime Sano, Tsuyoshi Iwasaki A Comparative Proteomics Study of a Synovial Cell Line Stimulated With TNF-α FEBS Open Bio 2016 6 (5), 418-24 PubMed ID: 27419047 DOI: 10.1002/2211-5463.12049

14142 Ferguson GD, Delgado M, Plantevin-Krenitsky V, Jensen-Pergakes K, Bates RJ, Torres S, Celeridad M, Brown H, Burnett K, Nadolny L, Tehrani L, Packard G, Pagarigan B, Haelewyn J, Nguyen T, Xu L, Tang Y, Hickman M, Baculi F, Pierce S, Miyazawa K, Jackson P, Chamberlain P, LeBrun L, Xie W, Bennett B, Blease K. A Novel Triazolopyridine-Based Spleen Tyrosine Kinase Inhibitor That Arrests Joint Inflammation PLoS One 2016 11(1):e0145705 PubMed ID: 26756335 DOI: 10.1371/journal.pone.0145705

7188 Jia Q, Cheng W, Yue Y, Hu Y, Zhang J, Pan X, Xu Z, Zhang P. Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways. Int. Immunopharmacol. 2015 29:884-890 PubMed ID: 26453509 DOI: 10.1016/j.intimp.2015.08.026

12290 Hideya Igarashi, Hiroyasu Hirano, Ayano Yahagi, Taro Saika, Katsuhiko Ishihara Anti-apoptotic roles for the mutant p53R248Q through suppression of p53-regulated apoptosis-inducing protein 1 in the RA-derived fibroblast-like synoviocyte cell line MH7A Clin Immunol 2014 150(1):12-21 PubMed ID: 24316591 DOI: 10.1016/j.clim.2013.10.013

16993 Shibasaki S, Tsunemi S, Kitano S, Sekiguchi M, Sano H, Iwasaki T. Differential regulation of c-Met signaling pathways for synovial cell function Springerplus 2014 3:554 PubMed ID: 25332857 DOI: 10.1186/2193-1801-3-554

16996 Shibasaki S, Karasaki M, Gräslund T, Nygren PÅ, Sano H, Iwasaki T. Inhibitory effects of H-Ras/Raf-1-binding affibody molecules on synovial cell function AMB Express 2014 4(1):82 PubMed ID: 26267111 DOI: 10.1186/s13568-014-0082-3

10988 Geun-Hee Lee, Jiyoung Lee, Jae-Wook Lee, Whan Soo Choi, Eun-Yi Moon B cell activating factor-dependent expression of vascular endothelial growth factor in MH7A human synoviocytes stimulated with tumor necrosis factor-α Int Immunopharmacol 2013 17(1):142-7 PubMed ID: 23684916 DOI: 10.1016/j.intimp.2013.04.026

7598 Fujishiro M, Nozawa K, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol 2012 22:228-37 PubMed ID: 22203215 DOI: 10.1007/s10165-011-0564-y

7631 Igarashi H, Yahagi A, Saika T, Hashimoto J, Tomita T, Yoshikawa H, Ishihara K. A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis. Immunol. Lett. 2012 141:246-53 PubMed ID: 22093807 DOI: 10.1016/j.imlet.2011.10.011

7800 Tanaka Y, Matsumoto I, Iwanami K, Inoue A, Minami R, Umeda N, Kanamori A, Ochiai N, Miyazawa K, Sugihara M, Hayashi T, Goto D, Ito S, Sumida T. Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. Mod Rheumatol 2012 22:128-36 PubMed ID: 21633911 DOI: 10.1007/s10165-011-0475-y

12717 Nakayama H, Yaguchi T, Yoshiya S, Nishizaki T. Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner Rheumatol Int . 2012 Jan;32(1):151-7 2012 32(1):151-7 PubMed ID: 20697895 DOI: 10.1007/s00296-010-1598-8

16936 Haas S, Straub RH. Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoart Arthritis Res Ther 2012 14(3):R122 PubMed ID: 22621205 DOI: 10.1186/ar3852

7779 Seong AR, Yoo JY, Choi K, Lee MH, Lee YH, Lee J, Jun W, Kim S, Yoon HG. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells. Biochem. Biophys. Res. Commun. 2011 410:581-6 PubMed ID: 21683061 DOI: 10.1016/j.bbrc.2011.06.029

7997 Bader RA, Silvers AL, Zhang N. Polysialic acid-based micelles for encapsulation of hydrophobic drugs. Biomacromolecules 2011 12:314-20 PubMed ID: 21218771 DOI: 10.1021/bm1008603

16983 Law YY, Lee WF, Hsu CJ, Lin YY, Tsai CH, Huang CC, Wu MH, Tang CH, Liu JF. miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts Aging (Albany NY) 2011 13(13):17227-17236 PubMed ID: 34198264 DOI: 10.18632/aging.203201

16997 Araki H, Imaoka A, Kuboyama N, Abiko Y. Reduction of interleukin-6 expression in human synoviocytes and rheumatoid arthritis rat joints by linear polarized near infrared light (Superlizer) irradiation Laser Ther 2011 20(4):293-300 PubMed ID: 24155540 DOI: 10.5978/islsm.11-or_01

16998 Igarashi M, Kaga I, Takamori Y, Sakamoto K, Miyazawa K, Nagaoka I. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes Int J Mol Med 2011 27(6):821-7 PubMed ID: 21455564 DOI: 10.3892/ijmm.2011.662

8289 Bader RA, Wagoner KL. Modulation of the response of rheumatoid arthritis synovial fibroblasts to proinflammatory stimulants with cyclic tensile strain. Cytokine 2010 51:35-41 PubMed ID: 20399680 DOI: 10.1016/j.cyto.2010.03.015

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