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細胞番号 : 細胞名
RCB1483 : OV2944-HM-1  update : 2022/04/04
細胞特性(Comment:英)Lymphnode-metastatic ovarian tumor. So called HM-1 cells.
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Niwa, Ohtsura
樹立者 Niwa, O. & Irimura, T.
寄託日 1998
別名 HM-1
動物種 _mouse < Mammals
動物系統名 C57BL x C3H
性別 Female
採取組織 ovary
細胞分類 cancer
細胞寿命 infinite
細胞形態 fibroblast-like
Cellosaurus(Expasy) CVCL_E954
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM ALPHA + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
マウス系統検査 OK
アイソザイム検査 LD, NP
文献情報 Reference(英) 5件
Reference(日) 0件
利用者成果(英) 26件
利用者成果(日) 0件

2353  Abe Y, Tsutsui T, Mu J, Kosugi A, Yagita H, Sobue K, Niwa O, Fujiwara H, Hamaoka T  A defect in cell-to-cell adhesion via integrin-fibronectin interactions in a highly metastatic tumor cell line.  Jpn J Cancer Res  1997  88:64-71  PubMed ID: 9045898   DOI: 10.1111/j.1349-7006.1997.tb00303.x
2354  Ichii S, Imai Y, Irimura T  Tumor site-selective localization of an adoptively transferred T cell line expressing a macrophage lectin.  J Leukoc Biol  1997  62:761-70  PubMed ID: 9400817   DOI: 10.1002/jlb.62.6.761
2352  Mu J, Abe Y, Tsutsui T, Yamamoto N, Tai, X G, Niwa O, Tsujimura T, Sato B, Terano H, Fujiwara H, Hamaoka T  Inhibition of growth and metastasis of avarian carcinoma by administering a drug capable of interfering with vascular endothelial growth factor acitivity  Jpn J Cancer Res  1996  87:963-971  PubMed ID: 8878460   DOI: 10.1111/j.1349-7006.1996.tb02127.x
2351  Imai Y, Akimoto Y, Mizuochi S, Kimura T, Hirano H, Irimura T  Restricted expression of galactose/N-acetylgalactosamine-specific macrophage C-type lectin to connective tissue and to metastatic lesions in mouse lung.  Immunology  1995  86:591-8  PubMed ID: 8567026  
2350  Hashimoto M, Niwa O, Nitta Y, Takeichi M, Yokoro K  Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells  Jpn J Cancer Res  1989  80:459-463  PubMed ID: 2502522   DOI: 10.1111/j.1349-7006.1989.tb02336.x


21694  Hirasawa H, Aoba K, Miwa N.  Acid-Sensitive Outwardly Rectifying Cl- Current in OV2944 Mouse Ovarian Cancer Cells.  Cell Physiol Biochem  2024  58(2):172-181  PubMed ID: 38643508   DOI: 10.33594/000000692
21132  Barberio AE, Smith SG, Pires IS, Iyer S, Reinhardt F, Melo MB, Suh H, Weinberg RA, Irvine DJ, Hammond PT.  Layer-by-layer interleukin-12 nanoparticles drive a safe and effective response in ovarian tumors.  Bioeng Transl Med  2023  8(2):e10453  PubMed ID: 36925719   DOI: 10.1002/btm2.10453
21220  Cao K, Zhang G, Yang M, Wang Y, He M, Zhang C, Huang Y, Lu J, Liu H.  Attenuation of sialylation augments antitumor immunity and improves response to immunotherapy in ovarian cancer.  Cancer Res  2023    PubMed ID: 37172314   DOI: 10.1158/0008-5472.CAN-22-3260
20496  Ishikura N, Sugimoto M, Yorozu K, Kurasawa M, Kondoh O.  Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1low and immune desert‑like mouse tumors.  Oncol Rep  2022  47(2)  PubMed ID: 34958105   DOI: 10.3892/or.2021.8247
16437  Miyamoto T, Murakami R, Hamanishi J, Tanigaki K, Hosoe Y, Mise N, Takamatsu S, Mise Y, Ukita M, Taki M, Yamanoi K, Horikawa N, Abiko K, Yamaguchi K, Baba T, Matsumura N, Mandai M.  B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression  Cancer Immunol Res  2022  10(1):56-69.  PubMed ID: 34799346   DOI: 10.1158/2326-6066.CIR-21-0407
20694  Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, Suzuki H, Hosoe Y, Furutake Y, Taki M, Abiko K, Yamaguchi K, Nakai H, Baba T, Matsumura N, Yoshizawa A, Ueno H, Mandai M.  CXCL13-producing CD4+ T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer.  JCI Insight  2022    PubMed ID: 35552285   DOI: 10.1172/jci.insight.157215
14343  Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.  Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models  Cancer Immunol Immunother  2021    PubMed ID: 33559069   DOI: 10.1007/s00262-021-02853-3
20242  Mori T, Hazekawa M, Yoshida M, Nishinakagawa T, Uchida T, Ishibashi D.  Enhancing the anticancer efficacy of a LL-37 peptide fragment analog using peptide-linked PLGA conjugate micelles in tumor cells.  Int J Pharm  2021  120891  PubMed ID: 34324984   DOI: 10.1016/j.ijpharm.2021.120891
9914  Naoki Horikawa, Kaoru Abiko, Noriomi Matsumura, Tsukasa Baba, Junzo Hamanishi, Ken Yamaguchi, Ryusuke Murakami, Mana Taki, Masayo Ukita, Yuko Hosoe, Masafumi Koshiyama, Ikuo Konishi, Masaki Mandai  Anti-VEGF Therapy Resistance in Ovarian Cancer Is Caused by GM-CSF-induced Myeloid-Derived Suppressor Cell Recruitment  Br J Cancer  2020  122(6):778-788  PubMed ID: 31932754   DOI: 10.1038/s41416-019-0725-x
13079  Komura N, Mabuchi S, Shimura K, Yokoi E, Kozasa K, Kuroda H, Takahashi R, Sasano T, Kawano M, Matsumoto Y, Kodama M, Hashimoto K, Sawada K, Kimura T.  The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer.  Cancer Immunol Immunother  2020    PubMed ID: 32561967   DOI: 10.1007/s00262-020-02628-2
13158  Yang M, Zhang G, Wang Y, He M, Xu Q, Lu J, Liu H, Xu C.  Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.  Br J Cancer  2020    PubMed ID: 32778818   DOI: 10.1038/s41416-020-1026-0
13282  Han N, Anwar D, Hama N, Kobayashi T, Suzuki H, Takahashi H, Wada H, Otsuka R, Baghdadi M, Seino KI.  Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells.  Inflamm Regen  2020    PubMed ID: 33072227   DOI: 10.1186/s41232-020-00129-4
16828  Barberio AE, Smith SG, Correa S, Nguyen C, Nhan B, Melo M, Tokatlian T, Suh H, Irvine DJ, Hammond PT.  Cancer Cell Coating Nanoparticles for Optimal Tumor-Specific Cytokine Delivery  ACS Nano  2020  14(9):11238-11253  PubMed ID: 32692155   DOI: 10.1021/acsnano.0c03109
11603  Aoki N, Matsui Y.  Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.  Mol. Cell. Biol.  2019    PubMed ID: 31208979   DOI: 10.1128/MCB.00154-19
6962  Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M.  Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model.  J Pharmacol Sci  2019  139(3):231-239  PubMed ID: 30803892   DOI: 10.1016/j.jphs.2019.01.009
10833  Taki M, Abiko K, Baba T, Hamanishi J, Yamaguchi K, Murakami R, Yamanoi K, Horikawa N, Hosoe Y, Nakamura E, Sugiyama A, Mandai M, Konishi I, Matsumura N.  Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation.  Nat Commun  2018  9:1685  PubMed ID: 29703902   DOI: 10.1038/s41467-018-03966-7
14925  Nakagawa S, Serada S, Kakubari R, Hiramatsu K, Sugase T, Matsuzaki S, Matsuzaki S, Ueda Y, Yoshino K, Ohkawara T, Fujimoto M, Kishimoto T, Kimura T, Naka T.  Intratumoral Delivery of an Adenoviral Vector Carrying the SOCS-1 Gene Enhances T-Cell-Mediated Antitumor Immunity By Suppressing PD-L1  Mol Cancer Ther  2018  17(9):1941-1950.  PubMed ID: 29891489   DOI: 10.1158/1535-7163.MCT-17-0822
14927  Taha AAA, Koshiyama M, Matsumura N, Abiko K, Yamaguchi K, Hamanishi J, Baba T, Kharma B, Mohamed IH, Ameen MM, Ismail SA, Konishi I, Mandai M.  The effect of the type of dietary protein on the development of ovarian cancer  Oncotarget   2018  9(35):23987-23999  PubMed ID: 29844867   DOI: 10.18632/oncotarget.25253
14348  Horikawa N, Abiko K, Matsumura N, Hamanishi J, Baba T, Yamaguchi K, Yoshioka Y, Koshiyama M, Konishi I.  Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells  Clin Cancer Res  2017  23(2):587-599  PubMed ID: 27401249   DOI: 10.1158/1078-0432.CCR-16-0387
7149  Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, Yamaguchi K, Horikawa N, Hosoe Y, Murphy SK, Konishi I, Mandai M.  Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.  Cancer Res.  2015  75:5034-45  PubMed ID: 26573793   DOI: 10.1158/0008-5472.CAN-14-3098
7194  Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T.  AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer.  Eur. J. Pharmacol.  2015  766:63-75  PubMed ID: 26410360   DOI: 10.1016/j.ejphar.2015.09.039
15068  Abiko K, Matsumura N, Hamanishi J, Horikawa N, Murakami R, Yamaguchi K, Yoshioka Y, Baba T, Konishi I, Mandai M.  IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer  Br J Cancer  2015  112(9):1501-9  PubMed ID: 25867264   DOI: 10.1038/bjc.2015.101
9104  Fumi Goshima, Shinichi Esaki, Chenhong Luo, Maki Kamakura, Hiroshi Kimura, Yukihiro Nishiyama  Oncolytic Viral Therapy With a Combination of HF10, a Herpes Simplex Virus Type 1 Variant and Granulocyte-Macrophage Colony-Stimulating Factor for Murine Ovarian Cancer  Int J Cancer  2014  134 (12), 2865-77  PubMed ID: 24265099   DOI: 10.1002/ijc.28631
14926  Tanizaki Y, Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.  Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment  Cancer Sci  2014  105(8):966-73  PubMed ID: 24826982   DOI: 10.1111/cas.12445
17139  Manthana Mitchai, Niramon Leeratanapetch, Viraphong Lulitanond, Pattaravadee Srikoon, Shinichiro Hattori, Kulthida Vaeteewoottacharn, Sopit Wongkham, Seiji Okada  Phenotypic Characteristics and Function of NK Cell Subsets in cART-Treated HIV-1-Infected Individuals  World Journal of AIDS  2014  04:293-300    DOI: 10.4236/wja.2014.43034
18667  Toyoshima M, Tanaka Y, Matumoto M, Yamazaki M, Nagase S, Sugamura K, Yaegashi N.  Generation of a syngeneic mouse model to study the intraperitoneal dissemination of ovarian cancer with in vivo luciferase imaging  Luminescence  2009  24(5):324-31  PubMed ID: 19711487   DOI: 10.1002/bio.1112


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