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Cell No. : Cell Name
RCB1483 : OV2944-HM-1  update : 2022/04/04
CommentLymphnode-metastatic ovarian tumor. So called HM-1 cells.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Niwa, Ohtsura
Originator Niwa, O. & Irimura, T.
Year of deposit 1998
Another name HM-1
Animal mouse < Mammals
Strain name C57BL x C3H
Gender Female
Tissue ovary
Classification cancer
Lifespan infinite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_E954
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM ALPHA + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 5
User's Publication 20


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Reference
2353  Abe Y, Tsutsui T, Mu J, Kosugi A, Yagita H, Sobue K, Niwa O, Fujiwara H, Hamaoka T  A defect in cell-to-cell adhesion via integrin-fibronectin interactions in a highly metastatic tumor cell line.  Jpn J Cancer Res  1997  88:64-71  PubMed ID: 9045898
2354  Ichii S, Imai Y, Irimura T  Tumor site-selective localization of an adoptively transferred T cell line expressing a macrophage lectin.  J Leukoc Biol  1997  62:761-70  PubMed ID: 9400817
2352  Mu J, Abe Y, Tsutsui T, Yamamoto N, Tai, X G, Niwa O, Tsujimura T, Sato B, Terano H, Fujiwara H, Hamaoka T  Inhibition of growth and metastasis of avarian carcinoma by administering a drug capable of interfering with vascular endothelial growth factor acitivity  Jpn J Cancer Res  1996  87:963-971  PubMed ID: 8878460
2351  Imai Y, Akimoto Y, Mizuochi S, Kimura T, Hirano H, Irimura T  Restricted expression of galactose/N-acetylgalactosamine-specific macrophage C-type lectin to connective tissue and to metastatic lesions in mouse lung.  Immunology  1995  86:591-8  PubMed ID: 8567026
2350  Hashimoto M, Niwa O, Nitta Y, Takeichi M, Yokoro K  Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells  Jpn J Cancer Res  1989  80:459-463  PubMed ID: 2502522

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User's Publication
20496  Ishikura N, Sugimoto M, Yorozu K, Kurasawa M, Kondoh O.  Anti‑VEGF antibody triggers the effect of anti‑PD‑L1 antibody in PD‑L1low and immune desert‑like mouse tumors.  Oncol Rep  2022  47(2)  PubMed ID: 34958105
16437  Miyamoto T, Murakami R, Hamanishi J, Tanigaki K, Hosoe Y, Mise N, Takamatsu S, Mise Y, Ukita M, Taki M, Yamanoi K, Horikawa N, Abiko K, Yamaguchi K, Baba T, Matsumura N, Mandai M.  B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression  Cancer Immunol Res  2022  10(1):56-69.  PubMed ID: 34799346
20694  Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, Suzuki H, Hosoe Y, Furutake Y, Taki M, Abiko K, Yamaguchi K, Nakai H, Baba T, Matsumura N, Yoshizawa A, Ueno H, Mandai M.  CXCL13-producing CD4+ T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer.  JCI Insight  2022    PubMed ID: 35552285
14343  Goto S, Sakoda Y, Adachi K, Sekido Y, Yano S, Eto M, Tamada K.  Enhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models  Cancer Immunol Immunother  2021    PubMed ID: 33559069
20242  Mori T, Hazekawa M, Yoshida M, Nishinakagawa T, Uchida T, Ishibashi D.  Enhancing the anticancer efficacy of a LL-37 peptide fragment analog using peptide-linked PLGA conjugate micelles in tumor cells.  Int J Pharm  2021  120891  PubMed ID: 34324984
9914  Naoki Horikawa, Kaoru Abiko, Noriomi Matsumura, Tsukasa Baba, Junzo Hamanishi, Ken Yamaguchi, Ryusuke Murakami, Mana Taki, Masayo Ukita, Yuko Hosoe, Masafumi Koshiyama, Ikuo Konishi, Masaki Mandai  Anti-VEGF Therapy Resistance in Ovarian Cancer Is Caused by GM-CSF-induced Myeloid-Derived Suppressor Cell Recruitment  Br J Cancer  2020  122(6):778-788  PubMed ID: 31932754
13079  Komura N, Mabuchi S, Shimura K, Yokoi E, Kozasa K, Kuroda H, Takahashi R, Sasano T, Kawano M, Matsumoto Y, Kodama M, Hashimoto K, Sawada K, Kimura T.  The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer.  Cancer Immunol Immunother  2020    PubMed ID: 32561967
13158  Yang M, Zhang G, Wang Y, He M, Xu Q, Lu J, Liu H, Xu C.  Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.  Br J Cancer  2020    PubMed ID: 32778818
13282  Han N, Anwar D, Hama N, Kobayashi T, Suzuki H, Takahashi H, Wada H, Otsuka R, Baghdadi M, Seino KI.  Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells.  Inflamm Regen  2020    PubMed ID: 33072227
11603  Aoki N, Matsui Y.  Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.  Mol. Cell. Biol.  2019    PubMed ID: 31208979
6962  Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M.  Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model.  J Pharmacol Sci  2019  139(3):231-239  PubMed ID: 30803892
10833  Taki M, Abiko K, Baba T, Hamanishi J, Yamaguchi K, Murakami R, Yamanoi K, Horikawa N, Hosoe Y, Nakamura E, Sugiyama A, Mandai M, Konishi I, Matsumura N.  Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation.  Nat Commun  2018  9:1685  PubMed ID: 29703902
14925  Nakagawa S, Serada S, Kakubari R, Hiramatsu K, Sugase T, Matsuzaki S, Matsuzaki S, Ueda Y, Yoshino K, Ohkawara T, Fujimoto M, Kishimoto T, Kimura T, Naka T.  Intratumoral Delivery of an Adenoviral Vector Carrying the SOCS-1 Gene Enhances T-Cell-Mediated Antitumor Immunity By Suppressing PD-L1  Mol Cancer Ther  2018  17(9):1941-1950.  PubMed ID: 29891489
14927  Taha AAA, Koshiyama M, Matsumura N, Abiko K, Yamaguchi K, Hamanishi J, Baba T, Kharma B, Mohamed IH, Ameen MM, Ismail SA, Konishi I, Mandai M.  The effect of the type of dietary protein on the development of ovarian cancer  Oncotarget   2018  9(35):23987-23999  PubMed ID: 29844867
14348  Horikawa N, Abiko K, Matsumura N, Hamanishi J, Baba T, Yamaguchi K, Yoshioka Y, Koshiyama M, Konishi I.  Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells  Clin Cancer Res  2017  23(2):587-599  PubMed ID: 27401249
7149  Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, Yamaguchi K, Horikawa N, Hosoe Y, Murphy SK, Konishi I, Mandai M.  Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.  Cancer Res.  2015  75:5034-45  PubMed ID: 26573793
7194  Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T.  AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer.  Eur. J. Pharmacol.  2015  766:63-75  PubMed ID: 26410360
15068  Abiko K, Matsumura N, Hamanishi J, Horikawa N, Murakami R, Yamaguchi K, Yoshioka Y, Baba T, Konishi I, Mandai M.  IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer  Br J Cancer  2015  112(9):1501-9  PubMed ID: 25867264
9104  Fumi Goshima, Shinichi Esaki, Chenhong Luo, Maki Kamakura, Hiroshi Kimura, Yukihiro Nishiyama  Oncolytic Viral Therapy With a Combination of HF10, a Herpes Simplex Virus Type 1 Variant and Granulocyte-Macrophage Colony-Stimulating Factor for Murine Ovarian Cancer  Int J Cancer  2014  134 (12), 2865-77  PubMed ID: 24265099
14926  Tanizaki Y, Kobayashi A, Toujima S, Shiro M, Mizoguchi M, Mabuchi Y, Yagi S, Minami S, Takikawa O, Ino K.  Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment  Cancer Sci  2014  105(8):966-73  PubMed ID: 24826982



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