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19811
Une S, Nakata R, Nonaka K, Akiyama J.
Antiproliferative and anti-inflammatory effects of fractionated crude lectins from boiled kidney beans (Phaseolus vulgaris)
J Food Sci
2024
89(1):671-683
PubMed ID: 37983860
DOI: 10.1111/1750-3841.16847
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21616
Sakuda T, Oda A, Furuta T, Johan MP, Sakaguchi T, Adachi N.
Synergistic VSV Virotherapy and Carbon Nanotube Photothermal Therapy for Osteosarcoma in Murine Models.
Anticancer Res
2024
44(1):99-105
PubMed ID: 38159977
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21875
Ota Y, Inagaki R, Nagai Y, Hirose Y, Murata M, Yamamoto S.
TLR7 agonist, DSP-0509, with radiation combination therapy enhances anti-tumor activity and modulates T cell dependent immune activation.
BMC Immunol
2024
25(1):48
PubMed ID: 39054418
DOI: 10.1186/s12865-024-00643-x
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19664
Nakamura K, Asanuma K, Okamoto T, Iino T, Hagi T, Nakamura T, Sudo A.
Combination of Everolimus and Bortezomib Inhibits the Growth and Metastasis of Bone and Soft Tissue Sarcomas via JNK/p38/ERK MAPK and AKT Pathways
Cancers (Basel)
2023
15(9):2468
PubMed ID: 37173935
DOI: 10.3390/cancers15092468
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19728
Quartieri M, Puspitasari A, Vitacchio T, Durante M, Tinganelli W.
The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells
Front Cell Dev Biol
2023
11:1222809
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DOI: 10.3389/fcell.2023.1222809
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19823
Nishimura E, Fukuda K, Matsuda S, Kobayashi R, Matsui K, Takeuchi M, Okubo K, Hirahashi J, Nakamura R, Kawakubo H, Kitagawa Y.
Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration
Surg Today
2023
53(8):973-983
PubMed ID: 36592222
DOI: 10.1007/s00595-022-02637-x
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21083
Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Adachi N.
Oncolytic Effect of a Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA in an Osteosarcoma Mouse Model.
Anticancer Res
2023
43(3):1185-1191
PubMed ID: 36854523
DOI: 10.21873/anticanres.16264
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21134
Li Y, Katayama Y, Nie I, Nakano T, Sawaragi E, Sakamoto M, Yamanaka H, Tsuge I, Demura S, Yamada Y, Tsuchiya H, Morimoto N.
Development of a novel regenerative therapy for malignant bone tumors using an autograft containing tumor inactivated by high hydrostatic pressurization (HHP).
Regen Ther
2023
22:224-231
PubMed ID: 36923268
DOI: 10.1016/j.reth.2023.02.002
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16215
Manami Suzuki-Karasaki, Takashi Ando, Yushi Ochiai, Kenta Kawahara, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki
Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering
Int J Mol Sci
2022
23(3):1124
PubMed ID: 35163042
DOI: 10.3390/ijms23031124
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16237
Inoue M, Horiuchi K, Susa M, Taguchi E, Ishizaka T, Rikitake H, Matsuhashi Y, Chiba K.
Trabectedin suppresses osteosarcoma pulmonary metastasis in a mouse tumor xenograft model
J Orthop Res
2022
May 31
PubMed ID: 34057747
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20656
Ogiwara Y, Nakagawa M, Nakatani F, Uemura Y, Zhang R, Kudo-Saito C.
Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma.
Cancer Lett
2022
537:215690
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18103
Helm A, Tinganelli W, Simoniello P, Kurosawa F, Fournier C, Shimokawa T, Durante M.
Reduction of Lung Metastases in a Mouse Osteosarcoma Model Treated With Carbon Ions and Immune Checkpoint Inhibitors
Int J Radiat Oncol Biol Phys
2021
109(2):594-602
PubMed ID: 32980497
DOI: 10.1016/j.ijrobp.2020.09.041
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18214
Yurtsever A, Yoshida T, Badami Behjat A, Araki Y, Hanayama R, Fukuma T.
Structural and mechanical characteristics of exosomes from osteosarcoma cells explored by 3D-atomic force microscopy
Nanoscale
2021
13(13):6661-6677
PubMed ID: 33885545
DOI: 10.1039/d0nr09178b
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20032
Lin L, Wang H, Guo W, He E, Huang K, Zhao Q.
Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss.
Cell Signal
2021
82:109935
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DOI: 10.1016/j.cellsig.2021.109935
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13630
Hennessy M, Wahba A, Felix K, Cabrera M, Segura MG, Kundra V, Ravoori MK, Stewart J, Kleinerman ES, Jensen VB, Gopalakrishnan V, Pena R, Quach P, Kim G, Kivimäe S, Madakamutil L, Overwijk WW, Zalevsky J, Gordon N.
Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma
Int J Cancer
2021
148(8):1928-1937
PubMed ID: 33152115
DOI: 10.1002/ijc.33382
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14340
Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH.
CSF-1/CSF-1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-Cell Infiltration in the Sarcoma Microenvironment
Mol Cancer Ther
2021
PubMed ID: 34088832
DOI: 10.1158/1535-7163.MCT-20-0591
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14344
Araki Y, Aiba H, Yoshida T, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Nguyen TD, Ishii KA, Nojima T, Takahashi S, Murakami H, Tsuchiya H, Hanayama R.
Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p
Front Oncol
2021
11:667109.
PubMed ID: 34017686
DOI: 10.3389/fonc.2021.667109
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15140
Matsusaka K, Fujiwara Y, Pan C, Esumi S, Saito Y, Bi J, Nakamura Y, Mukunoki A, Takeo T, Nakagata N, Yoshii D, Fukuda R, Nagasaki T, Tanaka R, Komori H, Maeda H, Watanabe H, Tamada K, Komohara Y, Maruyama T.
α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages
Cancer Res
2021
canres.3471.2020
PubMed ID: 34210751
DOI: 10.1158/0008-5472.CAN-20-3471
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20267
Maruyama K, Okada T, Ueha T, Isohashi K, Ikeda H, Kanai Y, Sasaki K, Gentsu T, Ueshima E, Sofue K, Nogami M, Yamaguchi M, Sugimoto K, Sakai Y, Hatazawa J, Murakami T.
In vivo evaluation of percutaneous carbon dioxide treatment for improving intratumoral hypoxia using 18F-fluoromisonidazole PET-CT.
Oncol Lett
2021
21(3):207
PubMed ID: 33574946
DOI: 10.3892/ol.2021.12468
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20272
Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.
Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.
Sci Rep
2021
11(1):13471
PubMed ID: 34188113
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16104
Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Ohtori S, Yonemoto T.
The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
Anticancer Res
2021
41(10):4947-4955
PubMed ID: 34593442
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16109
Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Ohtori S, Yonemoto T.
The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression
Anticancer Res
2021
41(12):6013-6021
PubMed ID: 34848455
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16389
Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N.
Antitumor Effect of Sclerostin against Osteosarcoma
Cancers (Basel)
2021
13(23):6015
PubMed ID: 34885123
DOI: 10.3390/cancers13236015
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16865
Ando T, Suzuki-Karasaki M, Suzuki-Karasaki M, Ichikawa J, Ochiai T, Yoshida Y, Haro H, Suzuki-Karasaki Y.
Combined Anticancer Effect of Plasma-Activated Infusion and Salinomycin by Targeting Autophagy and Mitochondrial Morphology
Front Oncol
2021
11:593127
PubMed ID: 34150606
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11888
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
BMC Cancer
2020
20(1):25.
PubMed ID: 31914969
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11888
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
BMC Cancer
2020
20(1):25.
PubMed ID: 31914969
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12049
Yahiro K, Matsumoto Y, Yamada H, Endo M, Setsu N, Fujiwara T, Nakagawa M, Kimura A, Shimada E, Okada S, Oda Y, Nakashima Y.
Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes.
Cancer Immunol. Immunother.
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PubMed ID: 32047957
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13305
Wang X, Xue J, Ma B, Wu J, Chang J, Gelinsky M, Wu C.
Black Bioceramics: Combining Regeneration with Therapy.
Adv Mater
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13306
Ando T, Ichikawa J, Fujimaki T, Taniguchi N, Takayama Y, Haro H.
Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis.
Cancers (Basel)
2020
PubMed ID: 33114161
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13310
Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Adachi N.
Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA.
Anticancer Res
2020
PubMed ID: 33109569
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13532
Pan C, Fujiwara Y, Horlad H, Shiraishi D, Iriki T, Tsuboki J, Ikeda T, Komohara Y.
Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment
Front Pharmacol
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PubMed ID: 32256354
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14872
Ma L, Sakamoto Y, Kanai A, Otsuka H, Takahashi A, Kakimi K, Imai T, Shimokawa T.
Characterization of a Novel Murine Colon Carcinoma Subline with High-Metastatic Activity Established by In Vivo Selection Method
J Mol Sci
2020
21(8):2829
PubMed ID: 32325684
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15141
Takenaka W, Takahashi Y, Tamari K, Minami K, Katsuki S, Seo Y, Isohashi F, Koizumi M, Ogawa K.
Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma
Cancers (Basel)
2020
12(6):1546
PubMed ID: 32545427
DOI: 10.3390/cancers12061546
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12504
Takahashi Y, Yasui T, Minami K, Tamari K, Hayashi K, Otani K, Seo Y, Isohashi F, Koizumi M, Ogawa K.
Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma
Oncotarget
2019
10(6):633-646
PubMed ID: 30774761
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12505
Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N.
Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice
J Orthop Res
2019
37(5):1192-1201
PubMed ID: 30839125
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11337
Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y.
Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.
Int J Mol Sci
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PubMed ID: 30544854
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4277
Shimizu T, Fuchimoto Y, Okita H, Fukuda K, Kitagawa Y, Ueno S, Kuroda T.
A curative treatment strategy using tumor debulking surgery combined with immune checkpoint inhibitors for advanced pediatric solid tumors: An in vivo study using a murine model of osteosarcoma.
J. Pediatr. Surg.
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PubMed ID: 30266483
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4278
Johan MP, Kubo T, Furuta T, Sakuda T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N.
Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma.
J. Orthop. Res.
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9465
Tomohiko Tokunaga, Takashi Ando, Miki Suzuki-Karasaki, Tomohisa Ito, Asuka Onoe-Takahashi, Toyoko Ochiai, Masayoshi Soma , Yoshihiro Suzuki-Karasaki
Plasma-stimulated Medium Kills TRAIL-resistant Human Malignant Cells by Promoting Caspase-Independent Cell Death via Membrane Potential and Calcium Dynamics Modulation
Int J Oncol
2018
52(3):697-708
PubMed ID: 29393427
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14821
Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma
Cancer Res
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78(12):3255-3266
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Bisphenol A Inhibits Cell Proliferation and Reduces the Motile Potential of Murine LM8 Osteosarcoma Cells.
Anticancer Res.
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The effect of immune checkpoint inhibitors on lung metastases of osteosarcoma.
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Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells
Sci Rep
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Radiation Enhances the Efficacy of Antitumor Immunotherapy with an Immunocomplex of Interleukin-2 and Its Monoclonal Antibody
Anticancer Res
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37(12):6799-6806
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Xing Y, Tian Y, Kurosawa T, Matsui S, Touma M, Yanai T, Wu Q, Sugimoto K.
CCL11-induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis.
Genes Cells
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Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.
Mol Nutr Food Res
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Basic Research for Osteosarcoma Lung Metastasis (LM8)
Osteosarcoma
2016
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Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy
Oncotarget
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Dendritic cells combined with doxorubicin induces immunogenic cell death and exhibits antitumor effects for osteosarcoma
Oncol Lett
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A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound.
J Cancer
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J Functional Foods
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Anticancer Agents Med Chem
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Bioelectromagnetics
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Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines.
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