CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1450 : LM8]

2332 Asai T, Ueda T, Itoh K, Yoshioka K, Aoki Y, Mori S, Yoshikawa H Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung. Int J Cancer 1998 76:418-22 PubMed ID: 9579581 DOI: 10.1002/(sici)1097-0215(19980504)76:3<418::aid-ijc21>3.0.co;2-5

2333 Mori S, Ueda T, Kuratsu S, Hosono N, Izawa K, Uchida A Suppression of pulmonary metastasis by angiogenesis inhibitor TNP-470 in murine osteosarcoma. Int J Cancer 1995 61:148-52 PubMed ID: 7535752 DOI: 10.1002/ijc.2910610125

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21083 Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Adachi N. Oncolytic Effect of a Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA in an Osteosarcoma Mouse Model. Anticancer Res 2023 43(3):1185-1191 PubMed ID: 36854523 DOI: 10.21873/anticanres.16264

21134 Li Y, Katayama Y, Nie I, Nakano T, Sawaragi E, Sakamoto M, Yamanaka H, Tsuge I, Demura S, Yamada Y, Tsuchiya H, Morimoto N. Development of a novel regenerative therapy for malignant bone tumors using an autograft containing tumor inactivated by high hydrostatic pressurization (HHP). Regen Ther 2023 22:224-231 PubMed ID: 36923268 DOI: 10.1016/j.reth.2023.02.002

16215 Manami Suzuki-Karasaki, Takashi Ando, Yushi Ochiai, Kenta Kawahara, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering Int J Mol Sci 2022 23(3):1124 PubMed ID: 35163042 DOI: 10.3390/ijms23031124

16237 Inoue M, Horiuchi K, Susa M, Taguchi E, Ishizaka T, Rikitake H, Matsuhashi Y, Chiba K. Trabectedin suppresses osteosarcoma pulmonary metastasis in a mouse tumor xenograft model J Orthop Res 2022 May 31 PubMed ID: 34057747 DOI: 10.1002/jor.25105

20656 Ogiwara Y, Nakagawa M, Nakatani F, Uemura Y, Zhang R, Kudo-Saito C. Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma. Cancer Lett 2022 537:215690 PubMed ID: 35439537 DOI: 10.1016/j.canlet.2022.215690

18103 Helm A, Tinganelli W, Simoniello P, Kurosawa F, Fournier C, Shimokawa T, Durante M. Reduction of Lung Metastases in a Mouse Osteosarcoma Model Treated With Carbon Ions and Immune Checkpoint Inhibitors Int J Radiat Oncol Biol Phys 2021 109(2):594-602 PubMed ID: 32980497 DOI: 10.1016/j.ijrobp.2020.09.041

20032 Lin L, Wang H, Guo W, He E, Huang K, Zhao Q. Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss. Cell Signal 2021 82:109935 PubMed ID: 33529755 DOI: 10.1016/j.cellsig.2021.109935

13630 Hennessy M, Wahba A, Felix K, Cabrera M, Segura MG, Kundra V, Ravoori MK, Stewart J, Kleinerman ES, Jensen VB, Gopalakrishnan V, Pena R, Quach P, Kim G, Kivimäe S, Madakamutil L, Overwijk WW, Zalevsky J, Gordon N. Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma Int J Cancer 2021 148(8):1928-1937 PubMed ID: 33152115 DOI: 10.1002/ijc.33382

14340 Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH. CSF-1/CSF-1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-Cell Infiltration in the Sarcoma Microenvironment Mol Cancer Ther 2021 PubMed ID: 34088832 DOI: 10.1158/1535-7163.MCT-20-0591

14344 Araki Y, Aiba H, Yoshida T, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Nguyen TD, Ishii KA, Nojima T, Takahashi S, Murakami H, Tsuchiya H, Hanayama R. Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p Front Oncol 2021 11:667109. PubMed ID: 34017686 DOI: 10.3389/fonc.2021.667109

15140 Matsusaka K, Fujiwara Y, Pan C, Esumi S, Saito Y, Bi J, Nakamura Y, Mukunoki A, Takeo T, Nakagata N, Yoshii D, Fukuda R, Nagasaki T, Tanaka R, Komori H, Maeda H, Watanabe H, Tamada K, Komohara Y, Maruyama T. α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages Cancer Res 2021 canres.3471.2020 PubMed ID: 34210751 DOI: 10.1158/0008-5472.CAN-20-3471

20267 Maruyama K, Okada T, Ueha T, Isohashi K, Ikeda H, Kanai Y, Sasaki K, Gentsu T, Ueshima E, Sofue K, Nogami M, Yamaguchi M, Sugimoto K, Sakai Y, Hatazawa J, Murakami T. In vivo evaluation of percutaneous carbon dioxide treatment for improving intratumoral hypoxia using 18F-fluoromisonidazole PET-CT. Oncol Lett 2021 21(3):207 PubMed ID: 33574946 DOI: 10.3892/ol.2021.12468

20272 Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R. Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA. Sci Rep 2021 11(1):13471 PubMed ID: 34188113 DOI: 10.1038/s41598-021-92860-2

16104 Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Ohtori S, Yonemoto T. The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression Anticancer Res 2021 41(10):4947-4955 PubMed ID: 34593442 DOI: 10.21873/anticanres.15308

16109 Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Ohtori S, Yonemoto T. The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression Anticancer Res 2021 41(12):6013-6021 PubMed ID: 34848455 DOI: 10.21873/anticanres.15420

16389 Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N. Antitumor Effect of Sclerostin against Osteosarcoma Cancers (Basel) 2021 13(23):6015 PubMed ID: 34885123 DOI: 10.3390/cancers13236015

16865 Ando T, Suzuki-Karasaki M, Suzuki-Karasaki M, Ichikawa J, Ochiai T, Yoshida Y, Haro H, Suzuki-Karasaki Y. Combined Anticancer Effect of Plasma-Activated Infusion and Salinomycin by Targeting Autophagy and Mitochondrial Morphology Front Oncol 2021 11:593127 PubMed ID: 34150606 DOI: 10.3389/fonc.2021.593127

11888 Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N. Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells. BMC Cancer 2020 20(1):25. PubMed ID: 31914969 DOI: 10.1186/s12885-019-6499-y

12049 Yahiro K, Matsumoto Y, Yamada H, Endo M, Setsu N, Fujiwara T, Nakagawa M, Kimura A, Shimada E, Okada S, Oda Y, Nakashima Y. Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes. Cancer Immunol. Immunother. 2020 PubMed ID: 32047957 DOI: 10.1007/s00262-020-02508-9

13305 Wang X, Xue J, Ma B, Wu J, Chang J, Gelinsky M, Wu C. Black Bioceramics: Combining Regeneration with Therapy. Adv Mater 2020 PubMed ID: 33094493 DOI: 10.1002/adma.202005140

13306 Ando T, Ichikawa J, Fujimaki T, Taniguchi N, Takayama Y, Haro H. Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis. Cancers (Basel) 2020 PubMed ID: 33114161 DOI: 10.3390/cancers12113097

13310 Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Adachi N. Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA. Anticancer Res 2020 PubMed ID: 33109569 DOI: 10.21873/anticanres.14652

13532 Pan C, Fujiwara Y, Horlad H, Shiraishi D, Iriki T, Tsuboki J, Ikeda T, Komohara Y. Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment Front Pharmacol 2020 11:262 PubMed ID: 32256354 DOI: 10.3389/fphar.2020.00262

14872 Ma L, Sakamoto Y, Kanai A, Otsuka H, Takahashi A, Kakimi K, Imai T, Shimokawa T. Characterization of a Novel Murine Colon Carcinoma Subline with High-Metastatic Activity Established by In Vivo Selection Method J Mol Sci 2020 21(8):2829 PubMed ID: 32325684 DOI: 10.3390/ijms21082829

15141 Takenaka W, Takahashi Y, Tamari K, Minami K, Katsuki S, Seo Y, Isohashi F, Koizumi M, Ogawa K. Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma Cancers (Basel) 2020 12(6):1546 PubMed ID: 32545427 DOI: 10.3390/cancers12061546

12504 Takahashi Y, Yasui T, Minami K, Tamari K, Hayashi K, Otani K, Seo Y, Isohashi F, Koizumi M, Ogawa K. Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma Oncotarget 2019 10(6):633-646 PubMed ID: 30774761 DOI: 10.18632/oncotarget.26551

12505 Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N. Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice J Orthop Res 2019 37(5):1192-1201 PubMed ID: 30839125 DOI: 10.1002/jor.24277

11337 Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y. Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice. Int J Mol Sci 2018 PubMed ID: 30544854 DOI: 10.3390/ijms19123959

4277 Shimizu T, Fuchimoto Y, Okita H, Fukuda K, Kitagawa Y, Ueno S, Kuroda T. A curative treatment strategy using tumor debulking surgery combined with immune checkpoint inhibitors for advanced pediatric solid tumors: An in vivo study using a murine model of osteosarcoma. J. Pediatr. Surg. 2018 PubMed ID: 30266483 DOI: 10.1016/j.jpedsurg.2018.08.023

4278 Johan MP, Kubo T, Furuta T, Sakuda T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N. Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma. J. Orthop. Res. 2018 PubMed ID: 29637599 DOI: 10.1002/jor.23911

9465 Tomohiko Tokunaga, Takashi Ando, Miki Suzuki-Karasaki, Tomohisa Ito, Asuka Onoe-Takahashi, Toyoko Ochiai, Masayoshi Soma , Yoshihiro Suzuki-Karasaki Plasma-stimulated Medium Kills TRAIL-resistant Human Malignant Cells by Promoting Caspase-Independent Cell Death via Membrane Potential and Calcium Dynamics Modulation Int J Oncol 2018 52(3):697-708 PubMed ID: 29393427 DOI: 10.3892/ijo.2018.4251

14821 Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y. CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma Cancer Res 2018 78(12):3255-3266 PubMed ID: 29610117 DOI: 10.1158/0008-5472.CAN-17-2011

10239 Kidani T, Yasuda R, Miyawaki J, Oshima Y, Miura H, Masuno H. Bisphenol A Inhibits Cell Proliferation and Reduces the Motile Potential of Murine LM8 Osteosarcoma Cells. Anticancer Res. 2017 37:1711-1722 PubMed ID: 28373433 DOI: 10.21873/anticanres.11503

10496 Shimizu T, Fuchimoto Y, Fukuda K, Okita H, Kitagawa Y, Kuroda T. The effect of immune checkpoint inhibitors on lung metastases of osteosarcoma. J. Pediatr. Surg. 2017 52:2047-2050 PubMed ID: 28954696 DOI: 10.1016/j.jpedsurg.2017.08.030

14705 Tsuda Y, Tanikawa C, Miyamoto T, Hirata M, Yodsurang V, Zhang YZ, Imoto S, Yamaguchi R, Miyano S, Takayanagi H, Kawano H, Nakagawa H, Tanaka S, Matsuda K. Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells Sci Rep 2017 7(1):10739 PubMed ID: 28878391 DOI: 10.1038/s41598-017-11208-x

14753 Takahashi Y, Yasui T, Minami K, Tamari K, Otani K, Seo Y, Isohashi F, Koizumi M, Ogawa K. Radiation Enhances the Efficacy of Antitumor Immunotherapy with an Immunocomplex of Interleukin-2 and Its Monoclonal Antibody Anticancer Res 2017 37(12):6799-6806 PubMed ID: 29187458 DOI: 10.21873/anticanres.12140

9693 Xing Y, Tian Y, Kurosawa T, Matsui S, Touma M, Yanai T, Wu Q, Sugimoto K. CCL11-induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis. Genes Cells 2016 21:624-38 PubMed ID: 27169545 DOI: 10.1111/gtc.12371

9750 Fujiwara Y, Horlad H, Shiraishi D, Tsuboki J, Kudo R, Ikeda T, Nohara T, Takeya M, Komohara Y. Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells. Mol Nutr Food Res 2016 60:2467-2480 PubMed ID: 27393711 DOI: 10.1002/mnfr.201500995

9832 Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T. Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells. Lab. Invest. 2016 96:1050-62 PubMed ID: 27617401 DOI: 10.1038/labinvest.2016.82

10853 Kazuyuki Itoh Basic Research for Osteosarcoma Lung Metastasis (LM8) Osteosarcoma 2016 19-29 DOI: 10.1007/978-4-431-55696-1_2

12675 Dovedi SJ, Adlard AL, Ota Y, Murata M, Sugaru E, Koga-Yamakawa E, Eguchi K, Hirose Y, Yamamoto S, Umehara H, Honeychurch J, Cheadle EJ, Hughes G, Jewsbury PJ, Wilkinson RW, Stratford IJ, Illidge TM. Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy Oncotarget 2016 7(13):17035-46 PubMed ID: 26959743 DOI: 10.18632/oncotarget.7928

12971 Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H. Dendritic cells combined with doxorubicin induces immunogenic cell death and exhibits antitumor effects for osteosarcoma Oncol Lett 2016 11(3):2169-2175 PubMed ID: 26998143 DOI: 10.3892/ol.2016.4175

7121 Kato S, Mori S, Kodama T. A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound. J Cancer 2015 6:1282-94 PubMed ID: 26640589 DOI: 10.7150/jca.13028

7258 Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H. Dendritic cells combined with anti-GITR antibody produce antitumor effects in osteosarcoma. Oncol. Rep. 2015 34:1995-2001 PubMed ID: 26239052 DOI: 10.3892/or.2015.4161

7502 Nakata H, Miyazaki T, Iwasaki T, Nakamura A, Kidani T, Sakayama K, Masumoto J, Miura H. Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles. Oncol. Rep. 2015 33:1593-8 PubMed ID: 25633802 DOI: 10.3892/or.2015.3761

7528 Fujiwara Y, Shiraishi D, Yoshitomi M, Ikeda T, Mizuta H, Takeya M, Komohara Y Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype. J Functional Foods 2015 19:594-605 DOI: 10.1016/j.jff.2015.09.055

15438 Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Odani A, Tsuchiya H. Effectiveness of two novel anionic and cationic platinum complexes in the treatment of osteosarcoma Anticancer Agents Med Chem 2015 15(3):390-9 PubMed ID: 25511510 DOI: 10.2174/1871520615666141216151547

18092 Kawano M, Itonaga I, Iwasaki T, Tsumura H. Enhancement of antitumor immunity by combining anti-cytotoxic T lymphocyte antigen-4 antibodies and cryotreated tumor lysate-pulsed dendritic cells in murine osteosarcoma Oncol Rep 2013 29(3):1001-6 PubMed ID: 23291864 DOI: 10.3892/or.2013.2224

18091 Kawano M, Itonaga I, Iwasaki T, Tsuchiya H, Tsumura H. Anti-TGF-β antibody combined with dendritic cells produce antitumor effects in osteosarcoma Clin Orthop Relat Res 2012 470(8):2288-94 PubMed ID: 22415727 DOI: 10.1007/s11999-012-2299-2

7854 Zhang D, Pan X, Ohno S, Osuga T, Sawada S, Sato K. No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines. Bioelectromagnetics 2011 32:463-73 PubMed ID: 21480303 DOI: 10.1002/bem.20647

7959 Tsubaki M, Yamazoe Y, Yanae M, Satou T, Itoh T, Kaneko J, Kidera Y, Moriyama K, Nishida S. Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma. Cytokine 2011 54:100-7 PubMed ID: 21292498 DOI: 10.1016/j.cyto.2011.01.005

8036 Nakazawa Y, Arai H, Fujita N. The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Cancer Res. 2011 71:1146-55 PubMed ID: 21148752 DOI: 10.1158/0008-5472.CAN-10-2695

5862 Rojas A, González I, Rodríguez B, Romero J, Figueroa H, Llanos J, Morales E, Pérez-Castro R. Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells. Microbes Infect 2011 Sep;13(10):818-23 PubMed ID: 21609778 DOI: 10.1016/j.micinf.2011.04.005

8334 Kawano M, Nishida H, Nakamoto Y, Tsumura H, Tsuchiya H. Cryoimmunologic antitumor effects enhanced by dendritic cells in osteosarcoma. Clin. Orthop. Relat. Res. 2010 468:1373-83 PubMed ID: 20232181 DOI: 10.1007/s11999-010-1302-z

18095 Kawasoe Y, Yokouchi M, Ueno Y, Iwaya H, Yoshida H, Komiya S. Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma Oncol Rep 2009 22(5):1045-50 PubMed ID: 19787219 DOI: 10.3892/or_00000534

8693 Kamei S, Sakayama K, Tamashiro S, Aizawa J, Miyawaki J, Miyazaki T, Yamamoto H, Norimatsu Y, Masuno H. Ketoprofen in topical formulation decreases the matrix metalloproteinase-2 expression and pulmonary metastatic incidence in nude mice with osteosarcoma. J. Orthop. Res. 2009 27:909-15 PubMed ID: 19105229 DOI: 10.1002/jor.20832

3384 Ando, Takashi, Ichikawa, Jiro, Okamoto, Atsushi, Tasaka, Kachio, Nakao, Atsuhito, Hamada, Yoshiki Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines. J Orthop Res 2005 23:964-9 PubMed ID: 16023013 DOI: 10.1016/j.orthres.2005.01.010