Back Back
Cell No. : Cell Name
RCB1440 : ATN-1  update : 2022/11/08
CommentAdult T-cell leukemia. HTLV-1 pro-virus DNA(+). Based on the information by depositor; (1) this cell line possesses HTLV-1 pro-virus DNA, (2) the HTLV-1 proteins (p19, p24, p53, gp46) cannot be detected with western blotting.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)   Cell line to be handled at BSL 2(C-0070.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Naoe, Tomoki
Originator Naoe, Tomoki
Year of deposit 1998
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 47 years
Tissue blood
Classification cancer
Year of origin 1982
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_1073
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 5 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) LT 400
Virus (HTLV-1) DNA (+)
Isozyme LD, NP
Chromosome mode 83-89(50) : /84(5),85(8),86(17),87(13),88(4),89(1)
STR(human) OK
deposit info
lot info
Reference information Reference 1
User's Publication 10

To topTop
2349  Naoe T, Akao Y, Yamada K, Utsumi, K R, Koike K, Shamoto M, Koie K, Kurosawa Y, Kato K, Abe M, et al.  Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells.  Cancer Genet Cytogenet  1988  34:77-88  PubMed ID: 3260813   DOI: 10.1016/0165-4608(88)90171-9

To topTop
User's Publication
20599  Wang Y, Zheng N, Sun T, Zhao H, Chen Y, Liu C.  Role of TGM2 in T‑cell lymphoblastic lymphoma via regulation of IL‑6/JAK/STAT3 signalling.  Mol Med Rep  2022  25(3)  PubMed ID: 35014680   DOI: 10.3892/mmr.2022.12592
16945  Yano H, Fujiwara Y, Horlad H, Pan C, Kai K, Niino D, Ohsawa K, Higashi M, Nosaka K, Okuno Y, Tamaru JI, Mukasa A, Matsuoka M, Komohara Y.  Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy  Cancer Sci  2022  113(6):2129-2143  PubMed ID: 35343027   DOI: 10.1111/cas.15349
10693  Tatsuro Watanabe, Satoshi Yamashita, Hiroshi Ureshino, Kazuharu Kamachi, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Nao Yoshida, Naoko Hattori, Hideaki Nakamura, Akemi Sato, Atsushi Kawaguchi, Naoko Sueoka-Aragane, Kensuke Kojima, Seiji Okada, Toshikazu Ushijima, Shinya Kimura, Eisaburo Sueoka  Targeting Aberrant DNA Hypermethylation as a Driver of ATL Leukemogenesis Using the New Oral Demethylating Agent OR-2100  Blood  2020  136(7):871-884  PubMed ID: 32391874   DOI: 10.1182/blood.2019003084
10951  Yanlan Wang, Yue Liu, Changhua Zhou, Chunnian Wang, Ning Zhang, Donglin Cao, Qing Li, Zhong Wang  An AKR1C3-specific prodrug with potent anti-tumor activities against T-ALL  Leuk Lymphoma  2020  61(7):1660-1668  PubMed ID: 32091283   DOI: 10.1080/10428194.2020.1728746
13930  Kawamura K, Tanaka Y, Nakasone H, Ishihara Y, Kako S, Kobayashi S, Tanaka Y, Ohmori T, Uchimaru K, Okamoto S, Mineno J, Shiku H, Nishimura S, Kanda Y.  Development of a Unique T Cell Receptor Gene-Transferred Tax-Redirected T Cell Immunotherapy for Adult T Cell Leukemia  Biol Blood Marrow Transplant  2020  26(8):1377-1385  PubMed ID: 32311478   DOI: 10.1016/j.bbmt.2020.04.006
11579  Watanabe M, Sugawara A, Noguchi Y, Hirose T, Ōmura S, Sunazuka T, Horie R.  Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.  Eur J Med Chem  2019  178:636-647  PubMed ID: 31226655   DOI: 10.1016/j.ejmech.2019.05.079
6834  Yamagishi M et al  Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas.  Cell Rep  2019  29(8):2321-2337  PubMed ID: 31747604   DOI: 10.1016/j.celrep.2019.10.083
4150  Ito T, Kasai Y, Kumagai Y, Suzuki D, Ochiai-Noguchi M, Irikura D, Miyake S, Murakami Y.  Quantitative Analysis of Interaction Between CADM1 and Its Binding Cell-Surface Proteins Using Surface Plasmon Resonance Imaging.  Front Cell Dev Biol  2018    PubMed ID: 30131958   DOI: 10.3389/fcell.2018.00086
10269  Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.  Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages  J Clin Exp Hematop  2017  57:15-20  PubMed ID: 28420814   DOI: 10.3960/jslrt.17003
9736  Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.  TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma.  Oncol Lett  2016  12:1519-1524  PubMed ID: 27446463   DOI: 10.3892/ol.2016.4774

Back Back Return Top Page