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細胞番号 : 細胞名
RCB1366 : HuH-7  update : 2024/08/14
細胞特性(Comment:英)Said producing alpha-fetoprotein, alpha-antitrypsin, ceruloplasmin, fibrinogen, fibronectin, etc.
細胞特性(日)日本人肝癌。アルブミン、alpha-fetoprotein、alpha-antitrypsin、ceruloplasmin、fibrinogen、fibronectin、haptoglobin、transferrin等を産生すると言われている。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)A prior written permission of the approver(Depositor) is necessary for any kind of use including academic use and for-profit use.
使用条件(日)営利目的か非営利目的かを問わず、いかなる使用につきましても、承諾者(寄託者)から承諾を得ることが必要です。
備考(英)
備考(日)
承諾者住所
×
Japanese
住所
700-8558 岡山県岡山市北区鹿田町2-5-1
岡山大学   医歯薬学総合研究科 細胞生物学分野
阪口 政清 先生
Fax. 086-235-7400

English
Address
Okayama University Graduate School of Medicine
Dentistry, and Pharmaceutical Sciences, Department of Cell Biology
2-5-1 shikata-cho , Kita-ku , Okayama-shi, Okayama 700-8558 Japan
Dr.SAKAGUCHI Masakiyo
Fax. +81-86-235-7400
提供申込書類(英) Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   承諾書C-0002.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Huh, Nam, Ho
樹立者 Nakabayashi, Hidekazu
寄託日 1997
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
57 years
採取組織 liver
病名 Hepatoma
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0336
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 100U/ml Penicillin + 100μg/ml Streptomycin
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
ウィルス(HBV) (-)
ウィルス(HCV) (-)
アイソザイム検査 LD, NP, MPI, PepB
染色体検査 105-114(50) : 105(6),106(8),107(8),109(4),110(6)/
文献情報 Reference(英) 3件
Reference(日) 2件
利用者成果(英) 129件
利用者成果(日) 0件

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Reference(英)
3427  H Nakabayashi, K Taketa, T Yamane, M Oda, J Sato  Hormonal control of alpha-fetoprotein secretion in human hepatoma cell lines p  Cancer Res  1985  45(12 Pt 1):6379-83  PubMed ID: 2415243  
2578  Nakabayashi H, Taketa K, Yamane T, Miyazaki M, Miyano K, Sato J  Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium.  Gann  1984  75:151-8  PubMed ID: 6203805  
135  Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J  Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.  Cancer Res  1982  42:3858-63  PubMed ID: 6286115  

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Reference(日)
3449  中林 秀和, 武田 和久  高分化型ヒト肝癌由来細胞株“HuH-7”  岡山医学会雑誌  2012  124:231-238    DOI: 10.4044/joma.124.231
2579  Matuda, Kouichi  ヒト肝癌:HuH-7  生体の科学  1992  43:382   

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利用者成果(英)
19797  Kurosawa M, Kato F, Hishiki T, Ito S, Fujisawa H, Yamaguchi T, Moriguchi M, Hosokawa K, Watanabe T, Saito-Tarashima N, Minakawa N, Fujimuro M.  Sofosbuvir Suppresses the Genome Replication of DENV1 in Human Hepatic Huh7 Cells  Int J Mol Sci  2024  25(4):2022  PubMed ID: 38396699   DOI: 10.3390/ijms25042022
19864  Hori Y, Yoh T, Nishino H, Okura K, Kurimoto M, Takamatsu Y, Satoh M, Nishio T, Koyama Y, Ishii T, Iwaisako K, Seo S, Hatano E.  Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma  Carcinogenesis  2024  45(3):119-130  PubMed ID: 38123365   DOI: 10.1093/carcin/bgad094
21541  Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, Li J, Zhu L, Keith B, Simon MC.  Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer.  Nat Cancer  2024    PubMed ID: 38168934   DOI: 10.1038/s43018-023-00671-3
21676  Jinno R, Tanaka M, Komizu Y, Matsumoto Y, Matsushita T, Ishida S.  Selective elimination of tumorigenic cells from mixed culture of normal and tumorigenic cells using hybrid liposomes aimed at realizing of cell therapy.  Cytotechnology  2024  76(2):247-258  PubMed ID: 38495296   DOI: 10.1007/s10616-023-00613-y
21730  Su Y, Meng L, Ge C, Liu Y, Zhang C, Yang Y, Tian W, Tian H.  PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling.  J Exp Clin Cancer Res  2024  43(1):142  PubMed ID: 38745188   DOI: 10.1186/s13046-024-03062-3
21754  Nagano S, Unuma K, Aki T, Uemura K.  N-acetylcysteine alleviates arsenic trioxide-induced reductions in hepatic catalase gene expression both in vitro and in vivo.  Leg Med (Tokyo)  2024  69:102458  PubMed ID: 38781725   DOI: 10.1016/j.legalmed.2024.102458
21976  Lotter C, Kuzucu EÜ, Casper J, Alter CL, Puligilla RD, Detampel P, Lopez JS, Ham AS, Huwyler J.  Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery.  Eur J Pharm Sci  2024  106898  PubMed ID: 39260517   DOI: 10.1016/j.ejps.2024.106898
22051  Shinohara S, Uchijima S, Hirosawa K, Nagaoka M, Nakano M, Nakajima M, Fukami T.  Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis.  Arch Toxicol  2024    PubMed ID: 39367970   DOI: 10.1007/s00204-024-03873-5
22100  Zhang L, Dang N, Wang J, Zhang W, Hu X, Jiang B, Zhao D, Liu F, Yuan H.  ZNF143-mediated upregulation of MEX3C promotes hepatocellular carcinoma progression.  Clin Res Hepatol Gastroenterol  2024  102492  PubMed ID: 39488269   DOI: 10.1016/j.clinre.2024.102492
22158  Degtev D, Bravo J, Emmanouilidi A, Zdravković A, Choong OK, Liz Touza J, Selfjord N, Weisheit I, Francescatto M, Akcakaya P, Porritt M, Maresca M, Taylor D, Sienski G.  Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles.  Nat Commun  2024  15(1):9173  PubMed ID: 39511150   DOI: 10.1038/s41467-024-53418-8
22178  Min X, Lin F, Zhao X, Yu J, Ge C, Zhang S, Li X, Zhao F, Chen T, Tian H, Yan M, Li J, Li H.  TENT5A mediates the cancer-inhibiting effects of EGR1 by suppressing the protein stability of RPL35 in hepatocellular carcinoma.  Cell Oncol (Dordr)  2024    PubMed ID: 39570560   DOI: 10.1007/s13402-024-01014-9
17740  Sagna A, Nair RVR, Hulyalkar N, Rajasekharan S, Nair VTG, Sivakumar KC, Suja SR, Baby S, Sreekumar E.  Ethyl palmitate, an anti-chikungunya virus principle from Sauropus androgynus, a medicinal plant used to alleviate fever in ethnomedicine  J Ethnopharmacol  2023  309:116366  PubMed ID: 36914036   DOI: 10.1016/j.jep.2023.116366
19733  Ito C, Haraguchi R, Ogawa K, Iwata M, Kitazawa R, Takada Y, Kitazawa S.  Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression  Histochem Cell Biol  2023  160(5):407-418  PubMed ID: 37532885   DOI: 10.1007/s00418-023-02229-x
21105  Chen J, Zhang J, Tian W, Ge C, Su Y, Li J, Tian H.  AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway.  Mol Carcinog  2023    PubMed ID: 36920042   DOI: 10.1002/mc.23527
21114  Miyazaki K, Morine Y, Xu C, Nakasu C, Wada Y, Teraoku H, Yamada S, Saito Y, Ikemoto T, Shimada M, Goel A.  Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma.  Cells  2023  12(4)  PubMed ID: 36831279   DOI: 10.3390/cells12040612
21118  Aki T, Kukita M, Takata M, Funakoshi T, Unuma K, Uemura K.  Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure.  Biochem Biophys Res Commun  2023  651:92-97  PubMed ID: 36801614   DOI: 10.1016/j.bbrc.2023.02.020
21153  Yang W, Miyazaki T, Nakagawa Y, Boonstra E, Masuda K, Nakashima Y, Chen P, Mixich L, Barthelmes K, Matsumoto A, Mi P, Uchida S, Cabral H.  Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π-π stacking-assisted micellar assembly.  Sci Technol Adv Mater  2023  24(1):2170164  PubMed ID: 36950277   DOI: 10.1080/14686996.2023.2170164
21173  Sanchez-Moral L, Paul T, Martori C, Font-Díaz J, Sanjurjo L, Aran G, Téllez É, Blanco J, Carrillo J, Ito M, Tuttolomondo M, Ditzel HJ, Fumagalli C, Tapia G, Sidorova J, Masnou H, Fernández-Sanmartín MA, Lozano JJ, Vilaplana C, Rodriguez-Cortés A, Armengol C, Valledor AF, Kremer L, Sarrias MR.  Macrophage CD5L is a target for cancer immunotherapy.  EBioMedicine  2023  91:104555  PubMed ID: 37054630   DOI: 10.1016/j.ebiom.2023.104555
21253  Muranaka M, Takamatsu S, Ouchida T, Kanazawa Y, Kondo J, Nakagawa T, Egashira Y, Fukagawa K, Gu J, Okamoto T, Kamada Y, Miyoshi E.  Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells.  Int J Mol Sci  2023  24(8)  PubMed ID: 37108200   DOI: 10.3390/ijms24087037
21273  Tomihari A, Kiyota M, Matsuura A, Itakura E.  Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins.  Sci Rep  2023  13(1):4680  PubMed ID: 36977730   DOI: 10.1038/s41598-023-31104-x
21314  Liu K, Nilsson R, Lázaro-Ibáñez E, Duàn H, Miliotis T, Strimfors M, Lerche M, Salgado Ribeiro AR, Ulander J, Lindén D, Salvati A, Sabirsh A.  Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function.  Nat Commun  2023  14(1):4007  PubMed ID: 37414857   DOI: 10.1038/s41467-023-39768-9
21349  Zhou L, Wang Z, Chen X, Li X, Ge C, Min X, Zhao F, Chen T, Li J.  Syntaxin-6 promotes the progression of hepatocellular carcinoma and alters its sensitivity to chemotherapies by activating the USF2/LC3B axis.  Int J Biol Sci  2023  19(12):3892-3907  PubMed ID: 37564208   DOI: 10.7150/ijbs.86636
21354  Aki T, Tanaka H, Funakoshi T, Unuma K, Uemura K.  Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.  Biochem Biophys Res Commun  2023  676:66-72  PubMed ID: 37487439   DOI: 10.1016/j.bbrc.2023.07.023
21392  Liu Q, Song Q, Luo C, Wei J, Xu Y, Zhao L, Wang Y.  A novel bispecific antibody as an immunotherapeutic agent in hepatocellular carcinoma.  Mol Immunol  2023  162:125-132  PubMed ID: 37677989   DOI: 10.1016/j.molimm.2023.08.007
21490  Su Y, Lin H, Yu J, Mao L, Jin W, Liu T, Jiang S, Wu Y, Zhang S, Geng Q, Ge C, Zhao F, Chen T, Cui Y, Li J, Hou H, Zhou X, Li H.  RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma.  J Exp Clin Cancer Res  2023  42(1):326  PubMed ID: 38017479   DOI: 10.1186/s13046-023-02892-x
20450  Castven D, Czauderna C, Becker D, Pereira S, Schmitt J, Weinmann A, Shah V, Hajduk J, Keggenhoff F, Binder H, Keck T, Heilmann-Heimbach S, Wörns MA, Thorgeirsson SS, Breuhahn K, Galle PR, Marquardt JU.  Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells.  Hepatol Commun  2022    PubMed ID: 34817932   DOI: 10.1002/hep4.1869
20482  Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.  Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.  Int J Oncol  2022  60(1)  PubMed ID: 34913069   DOI: 10.3892/ijo.2021.5294
16230  Takahiro Arai, Yu Aiki, Toshinori Sato  Accelerated transgene expression of pDNA/polysaccharide complexes by solid-phase reverse transfection and analysis of the cell transfection mechanism  Polymer Journal  2022      DOI: 10.1038/s41428-021-00603-x
20572  Roos NJ, Mancuso RV, Sanvee GM, Bouitbir J, Krähenbühl S.  Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines.  Food Chem Toxicol  2022  112869  PubMed ID: 35182693   DOI: 10.1016/j.fct.2022.112869
20615  Chen X, Wang Z, Zhao X, Zhang L, Zhou L, Li X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Tian H, Li H, Yao M, Li J.  STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.  Oncogene  2022    PubMed ID: 35314791   DOI: 10.1038/s41388-022-02273-2
20639  Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.  Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.  Oncol Rep  2022  47(4)  PubMed ID: 35169858   DOI: 10.3892/or.2022.8282
20707  Yamasaki Y, Kumekawa D, Yamauchi S, Omuro H.  Re-examination of Peptide-Sequence-Dependent Gene Expression of Cysteine-Installed Pegylated Oligolysine/DNA Complexes.  ACS Omega  2022  7(18):15478-15487  PubMed ID: 35571853   DOI: 10.1021/acsomega.2c00122
20828  Arai T, Sato T, Matsubara T.  Effective Cell Transfection in An Ultrasonically Levitated Droplet for Sustainable Technology.  Adv Sci (Weinh)  2022  e2203576  PubMed ID: 36026571   DOI: 10.1002/advs.202203576
20901  Samadaei M, Senfter D, Madlener S, Uranowska K, Hafner C, Trauner M, Rohr-Udilova N, Pinter M.  Targeting DNA repair to enhance the efficacy of sorafenib in hepatocellular carcinoma.  J Cell Biochem  2022    PubMed ID: 36271841   DOI: 10.1002/jcb.30340
21983  Hu X, Roy SR, Jin C, Li G, Zhang Q, Asano N, Asahina S, Kajiwara T, Takahara A, Feng B, Aoki K, Xu C, Zhang Y.  Control cell migration by engineering integrin ligand assembly.  Nat Commun  2022  13(1):5002  PubMed ID: 36008449   DOI: 10.1038/s41467-022-32686-2
13377  Feng R, Cui Z, Liu Z, Zhang Y.  Upregulated microRNA-132 in T helper 17 cells activates hepatic stellate cells to promote hepatocellular carcinoma cell migration in vitro.  Scand J Immunol  2021  93(5):e13007  PubMed ID: 33264420   DOI: 10.1111/sji.13007
13400  Yoshinaga N, Uchida S, Dirisala A, Naito M, Osada K, Cabral H, Kataoka K.  mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency.  J Control Release  2021  330:317-328  PubMed ID: 33359053   DOI: 10.1016/j.jconrel.2020.12.033
20081  Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.  The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.  Oncotarget  2021  12(4):333-343  PubMed ID: 33659044   DOI: 10.18632/oncotarget.27881
20136  El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.  MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33886022   DOI: 10.1245/s10434-021-09778-2
20166  Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.  CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.  Hepatol Commun  2021  5(2):334-348  PubMed ID: 33553979   DOI: 10.1002/hep4.1643
20169  Nicolle L, Casper J, Willimann M, Journot CMA, Detampel P, Einfalt T, Grisch-Chan HM, Thöny B, Gerber-Lemaire S, Huwyler J.  Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation.  Int J Mol Sci  2021  22(8)  PubMed ID: 33917124   DOI: 10.3390/ijms22083828
20177  Wang S, Lv Y, Zhou Y, Ling J, Wang H, Gu D, Wang C, Qin W, Zheng X, Jin H.  Acidic extracellular pH induces autophagy to promote anoikis resistance of hepatocellular carcinoma cells via downregulation of miR-3663-3p.  J Cancer  2021  12(12):3418-3426  PubMed ID: 33995620   DOI: 10.7150/jca.51849
20219  Chen S, Morine Y, Tokuda K, Yamada S, Saito Y, Nishi M, Ikemoto T, Shimada M.  Cancer‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway.  Int J Oncol  2021  59(2)  PubMed ID: 34195849   DOI: 10.3892/ijo.2021.5239
20250  Mudaliar P, Pradeep P, Abraham R, Sreekumar E.  Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK.  J Gen Virol  2021  102(7)  PubMed ID: 34328830   DOI: 10.1099/jgv.0.001629
20263  Czauderna C, Poplawski A, O Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU.  Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.  JCI Insight  2021    PubMed ID: 34375307   DOI: 10.1172/jci.insight.146196
20299  Yoshinaga N, Naito M, Tachihara Y, Boonstra E, Osada K, Cabral H, Uchida S.  PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials.  Pharmaceutics  2021  13(6)  PubMed ID: 34071840   DOI: 10.3390/pharmaceutics13060800
20327  Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Takasu C, Miyazaki K, Shimada M.  Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.  PLoS One  2021  16(9):e0256755  PubMed ID: 34473785   DOI: 10.1371/journal.pone.0256755
15515  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.  A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment  Cancers (Basel)  2021  13(16):3997  PubMed ID: 34439154   DOI: 10.3390/cancers13163997
20399  Sun F, Liu Y, Gong T, Pan Q, Xiang T, Zhao J, Tang Y, Chen H, Han Y, Song M, Huang Y, Li H, Chen Y, Yang C, Yang J, Wang Q, Li Y, He J, Weng D, Peng R, Xia J.  Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin.  Cell Death Dis  2021  12(12):1093  PubMed ID: 34795209   DOI: 10.1038/s41419-021-04375-3
20488  Yanazawa K, Sugasawa T, Aoki K, Nakano T, Kawakami Y, Takekoshi K.  Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.  PeerJ  2021  9:e12285  PubMed ID: 34721976   DOI: 10.7717/peerj.12285
20506  Shidoji Y, Iwao C.  A rapid increase in lysophospholipids after geranylgeranoic acid treatment in human hepatoma-derived HuH-7 cells revealed by metabolomics analysis.  Biochem Biophys Rep  2021  28:101176  PubMed ID: 34869922   DOI: 10.1016/j.bbrep.2021.101176
16727  Munson MJ, O'Driscoll G, Silva AM, Lázaro-Ibáñez E, Gallud A, Wilson JT, Collén A, Esbjörner EK, Sabirsh A.  A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery  Commun Biol  2021  4(1):211  PubMed ID: 33594247   DOI: 10.1038/s42003-021-01728-8
16875  Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Okikawa S, Takasu C, Shimada M.  The BAFF/NFκB axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts  Cancer Sci  2021  112(9):3545-3554  PubMed ID: 34159680   DOI: 10.1111/cas.15041
17032  Kazuko KANEDA-NAKASHIMA, Zijian ZHANG, Kojiro NAGATA, Kenji SHIRASAKI, Hidetoshi KIKUNAGA, Tomoo YAMAMURA, Kazuhiro OOE, Tadashi WATABE, Atsushi TOYOSHIMA, Takashi YOSHIMURA, Atsushi SHINOHARA  Dispersion of Alpha-Nuclides during Animal Experiments  Radiation Safety Management  2021  20:29-38    DOI: 10.12950/rsm.210519
17033  Liu T, Yu J, Ge C, Zhao F, Miao C, Jin W, Su Y, Geng Q, Chen T, Xie H, Cui Y, Yao M, Li J, Hou H, Li H.  B-Cell Receptor-Associated Protein 31 Promotes Metastasis via AKT/β-Catenin/Snail Pathway in Hepatocellular Carcinoma  Front Mol Biosci  2021  8:656151  PubMed ID: 34179078   DOI: 10.3389/fmolb.2021.656151
12072  Yu Q, Dai J, Shu M.  Retraction: Hsa_circ_0003645 shows an oncogenic role by sponging microRNA-1299 in hepatocellular carcinoma cells.  J. Clin. Lab. Anal.  2020    PubMed ID: 32108372   DOI: 10.1002/jcla.23249
13454  Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh  Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro  Personalized Medicine Universe  2020      DOI: 10.46459/pmu.2020001
13537  Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, Qin W, Luo X, Hao Y.  COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling  J Exp Clin Cancer Res  2020  39(1):148  PubMed ID: 32746865   DOI: 10.1186/s13046-020-01650-7
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