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Cell No. : Cell Name
RCB1366 : HuH-7  update : 2022/09/15
CommentSaid producing alpha-fetoprotein, alpha-antitrypsin, ceruloplasmin, fibrinogen, fibronectin, etc.
Comment from the depositor
Terms and conditionsA prior written permission of the approver(Depositor) is necessary for any kind of use including academic use and for-profit use.
Remarks
approver's address
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English
Address
Okayama University Graduate School of Medicine
Dentistry, and Pharmaceutical Sciences, Department of Cell Biology
2-5-1 shikata-cho , Kita-ku , Okayama-shi, Okayama 700-8558 Japan
Dr.SAKAGUCHI Masakiyo
Fax. +81-86-235-7400
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Huh, Nam, Ho
Originator Nakabayashi, Hidekazu
Year of deposit 1997
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 57 years
Tissue liver
Disease name Hepatoma
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0336
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics 100U/ml Penicillin + 100μg/ml Streptomycin
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP, MPI, PepB
Chromosome mode 105-114(50) : 105(6),106(8),107(8),109(4),110(6)/
Reference information Reference 3
User's Publication 76


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Reference
3427  H Nakabayashi, K Taketa, T Yamane, M Oda, J Sato  Hormonal control of alpha-fetoprotein secretion in human hepatoma cell lines p  Cancer Res  1985  45(12 Pt 1):6379-83  PubMed ID: 2415243  
2578  Nakabayashi H, Taketa K, Yamane T, Miyazaki M, Miyano K, Sato J  Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium.  Gann  1984  75:151-8  PubMed ID: 6203805  
135  Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J  Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.  Cancer Res  1982  42:3858-63  PubMed ID: 6286115  

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User's Publication
20450  Castven D, Czauderna C, Becker D, Pereira S, Schmitt J, Weinmann A, Shah V, Hajduk J, Keggenhoff F, Binder H, Keck T, Heilmann-Heimbach S, Wörns MA, Thorgeirsson SS, Breuhahn K, Galle PR, Marquardt JU.  Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells.  Hepatol Commun  2022    PubMed ID: 34817932   DOI: 10.1002/hep4.1869
20482  Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.  Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.  Int J Oncol  2022  60(1)  PubMed ID: 34913069   DOI: 10.3892/ijo.2021.5294
16230  Takahiro Arai, Yu Aiki, Toshinori Sato  Accelerated transgene expression of pDNA/polysaccharide complexes by solid-phase reverse transfection and analysis of the cell transfection mechanism  Polymer Journal  2022      DOI: 10.1038/s41428-021-00603-x
20572  Roos NJ, Mancuso RV, Sanvee GM, Bouitbir J, Krähenbühl S.  Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines.  Food Chem Toxicol  2022  112869  PubMed ID: 35182693   DOI: 10.1016/j.fct.2022.112869
20615  Chen X, Wang Z, Zhao X, Zhang L, Zhou L, Li X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Tian H, Li H, Yao M, Li J.  STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.  Oncogene  2022    PubMed ID: 35314791   DOI: 10.1038/s41388-022-02273-2
20639  Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.  Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.  Oncol Rep  2022  47(4)  PubMed ID: 35169858   DOI: 10.3892/or.2022.8282
20707  Yamasaki Y, Kumekawa D, Yamauchi S, Omuro H.  Re-examination of Peptide-Sequence-Dependent Gene Expression of Cysteine-Installed Pegylated Oligolysine/DNA Complexes.  ACS Omega  2022  7(18):15478-15487  PubMed ID: 35571853   DOI: 10.1021/acsomega.2c00122
20828  Arai T, Sato T, Matsubara T.  Effective Cell Transfection in An Ultrasonically Levitated Droplet for Sustainable Technology.  Adv Sci (Weinh)  2022  e2203576  PubMed ID: 36026571   DOI: 10.1002/advs.202203576
20901  Samadaei M, Senfter D, Madlener S, Uranowska K, Hafner C, Trauner M, Rohr-Udilova N, Pinter M.  Targeting DNA repair to enhance the efficacy of sorafenib in hepatocellular carcinoma.  J Cell Biochem  2022    PubMed ID: 36271841   DOI: 10.1002/jcb.30340
13377  Feng R, Cui Z, Liu Z, Zhang Y.  Upregulated microRNA-132 in T helper 17 cells activates hepatic stellate cells to promote hepatocellular carcinoma cell migration in vitro.  Scand J Immunol  2021  93(5):e13007  PubMed ID: 33264420   DOI: 10.1111/sji.13007
13400  Yoshinaga N, Uchida S, Dirisala A, Naito M, Osada K, Cabral H, Kataoka K.  mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency.  J Control Release  2021  330:317-328  PubMed ID: 33359053   DOI: 10.1016/j.jconrel.2020.12.033
20081  Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.  The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.  Oncotarget  2021  12(4):333-343  PubMed ID: 33659044   DOI: 10.18632/oncotarget.27881
20136  El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.  MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33886022   DOI: 10.1245/s10434-021-09778-2
20166  Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.  CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.  Hepatol Commun  2021  5(2):334-348  PubMed ID: 33553979   DOI: 10.1002/hep4.1643
20169  Nicolle L, Casper J, Willimann M, Journot CMA, Detampel P, Einfalt T, Grisch-Chan HM, Thöny B, Gerber-Lemaire S, Huwyler J.  Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation.  Int J Mol Sci  2021  22(8)  PubMed ID: 33917124   DOI: 10.3390/ijms22083828
20177  Wang S, Lv Y, Zhou Y, Ling J, Wang H, Gu D, Wang C, Qin W, Zheng X, Jin H.  Acidic extracellular pH induces autophagy to promote anoikis resistance of hepatocellular carcinoma cells via downregulation of miR-3663-3p.  J Cancer  2021  12(12):3418-3426  PubMed ID: 33995620   DOI: 10.7150/jca.51849
20219  Chen S, Morine Y, Tokuda K, Yamada S, Saito Y, Nishi M, Ikemoto T, Shimada M.  Cancer‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway.  Int J Oncol  2021  59(2)  PubMed ID: 34195849   DOI: 10.3892/ijo.2021.5239
20250  Mudaliar P, Pradeep P, Abraham R, Sreekumar E.  Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK.  J Gen Virol  2021  102(7)  PubMed ID: 34328830   DOI: 10.1099/jgv.0.001629
20299  Yoshinaga N, Naito M, Tachihara Y, Boonstra E, Osada K, Cabral H, Uchida S.  PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials.  Pharmaceutics  2021  13(6)  PubMed ID: 34071840   DOI: 10.3390/pharmaceutics13060800
20327  Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Takasu C, Miyazaki K, Shimada M.  Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.  PLoS One  2021  16(9):e0256755  PubMed ID: 34473785   DOI: 10.1371/journal.pone.0256755
15515  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.  A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment  Cancers (Basel)  2021  13(16):3997  PubMed ID: 34439154   DOI: 10.3390/cancers13163997
20399  Sun F, Liu Y, Gong T, Pan Q, Xiang T, Zhao J, Tang Y, Chen H, Han Y, Song M, Huang Y, Li H, Chen Y, Yang C, Yang J, Wang Q, Li Y, He J, Weng D, Peng R, Xia J.  Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin.  Cell Death Dis  2021  12(12):1093  PubMed ID: 34795209   DOI: 10.1038/s41419-021-04375-3
20488  Yanazawa K, Sugasawa T, Aoki K, Nakano T, Kawakami Y, Takekoshi K.  Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.  PeerJ  2021  9:e12285  PubMed ID: 34721976   DOI: 10.7717/peerj.12285
20506  Shidoji Y, Iwao C.  A rapid increase in lysophospholipids after geranylgeranoic acid treatment in human hepatoma-derived HuH-7 cells revealed by metabolomics analysis.  Biochem Biophys Rep  2021  28:101176  PubMed ID: 34869922   DOI: 10.1016/j.bbrep.2021.101176
16727  Munson MJ, O'Driscoll G, Silva AM, Lázaro-Ibáñez E, Gallud A, Wilson JT, Collén A, Esbjörner EK, Sabirsh A.  A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery  Commun Biol  2021  4(1):211  PubMed ID: 33594247   DOI: 10.1038/s42003-021-01728-8
16875  Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Okikawa S, Takasu C, Shimada M.  The BAFF/NFκB axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts  Cancer Sci  2021  112(9):3545-3554  PubMed ID: 34159680   DOI: 10.1111/cas.15041
17032  Kazuko KANEDA-NAKASHIMA, Zijian ZHANG, Kojiro NAGATA, Kenji SHIRASAKI, Hidetoshi KIKUNAGA, Tomoo YAMAMURA, Kazuhiro OOE, Tadashi WATABE, Atsushi TOYOSHIMA, Takashi YOSHIMURA, Atsushi SHINOHARA  Dispersion of Alpha-Nuclides during Animal Experiments  Radiation Safety Management  2021  20:29-38    DOI: 10.12950/rsm.210519
17033  Liu T, Yu J, Ge C, Zhao F, Miao C, Jin W, Su Y, Geng Q, Chen T, Xie H, Cui Y, Yao M, Li J, Hou H, Li H.  B-Cell Receptor-Associated Protein 31 Promotes Metastasis via AKT/β-Catenin/Snail Pathway in Hepatocellular Carcinoma  Front Mol Biosci  2021  8:656151  PubMed ID: 34179078   DOI: 10.3389/fmolb.2021.656151
12072  Yu Q, Dai J, Shu M.  Retraction: Hsa_circ_0003645 shows an oncogenic role by sponging microRNA-1299 in hepatocellular carcinoma cells.  J. Clin. Lab. Anal.  2020    PubMed ID: 32108372   DOI: 10.1002/jcla.23249
13454  Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh  Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro  Personalized Medicine Universe  2020      DOI: 10.46459/pmu.2020001
13537  Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, Qin W, Luo X, Hao Y.  COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling  J Exp Clin Cancer Res  2020  39(1):148  PubMed ID: 32746865   DOI: 10.1186/s13046-020-01650-7
14867  Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y, Han J, Duan Y.  Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity  J Hepatol  2020  73(6):1482-1495  PubMed ID: 32738448   DOI: 10.1016/j.jhep.2020.07.034
16623  Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H.  Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A  Anticancer Res  2020  40(1):161-168  PubMed ID: 31892564   DOI: 10.21873/anticanres.13937
11045  Haiqiu Wu, Cun Wang, Jiaxin Sun, Luyan Sun, Jiaxun Wan, Siying Wang, Dishui Gu, Chengtao Yu, Chen Yang, Jia He, Zihao Zhang, Yuanyuan Lv, Hui Wang, Ming Yao, Wenxin Qin, Changchun Wang, Haojie Jin  Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis  ACS Appl Mater Interfaces  2019  11(47):43996-44006  PubMed ID: 31682099   DOI: 10.1021/acsami.9b18086
14889  Tao X, Zuo Q, Ruan H, Wang H, Jin H, Cheng Z, Lv Y, Qin W, Wang C.  Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma  Acta Biochim Biophys Sin (Shanghai)  2019  51(3):263-276  PubMed ID: 30883650   DOI: 10.1093/abbs/gmz005
14557  Shinozawa E, Amano Y, Yamakawa H, Haba M, Shimada M, Tozawa R.  Antidyslipidemic potential of a novel farnesoid X receptor antagonist in a hamster model of dyslipidemia: Comparative studies of other nonstatin agents  Pharmacol Res Perspect  2018  6(2):e00390  PubMed ID: 29541476   DOI: 10.1002/prp2.390
10097  Zhang Y, Zhang LX, Liu XQ, Zhao FY, Ge C, Chen TY, Yao M, Li JJ.  Id4 promotes cell proliferation in hepatocellular carcinoma.  Chin J Cancer  2017  36:19  PubMed ID: 28143562   DOI: 10.1186/s40880-017-0186-7
10284  Singh S, Anupriya MG, Sreekumar E.  Comparative whole genome analysis of dengue virus serotype-2 strains differing in trans-endothelial cell leakage induction in vitro.  Infect. Genet. Evol.  2017  52:34-43  PubMed ID: 28456663   DOI: 10.1016/j.meegid.2017.04.022
9125  Sreeja R Nair, Rachy Abraham, Sankar Sundaram, Easwaran Sreekumar  Interferon Regulated Gene (IRG) Expression-Signature in a Mouse Model of Chikungunya Virus Neurovirulence  J Neurovirol   2017  23 (6), 886-902  PubMed ID: 29067635   DOI: 10.1007/s13365-017-0583-3
14207  Ge Z, Cheng Z, Yang X, Huo X, Wang N, Wang H, Wang C, Gu D, Zhao F, Yao M, Fan J, Qin W.  Long noncoding RNA SchLAH suppresses metastasis of hepatocellular carcinoma through interacting with fused in sarcoma  Cancer Sci  2017  108(4):653-662  PubMed ID: 28196303   DOI: 10.1111/cas.13200
14240  Sato T, Nakata M, Yang Z, Torizuka Y, Kishimoto S, Ishihara M.  In vitro and in vivo gene delivery using chitosan/hyaluronic acid nanoparticles: Influences of molecular mass of hyaluronic acid and lyophilization on transfection efficiency  J Gene Med  2017  19(8)  PubMed ID: 28667693   DOI: 10.1002/jgm.2968
12651  Zhang Y, Tao X, Jin G, Jin H, Wang N, Hu F, Luo Q, Shu H, Zhao F, Yao M, Fang J, Cong W, Qin W, Wang C.  Aggressiveness in Hepatocellular Carcinoma  Theranostics  2016  6(4):558-70  PubMed ID: 26941848   DOI: 10.7150/thno.14693
13987  Kawaguchi K, Okamoto T, Morita M, Imanaka T.  Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1  Sci Rep  2016  6:30183  PubMed ID: 27456980   DOI: 10.1038/srep30183
14136  Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.  Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma  Cancer Res  2016  76(11):3265-76  PubMed ID: 27197151   DOI: 10.1158/0008-5472.CAN-15-2601
12537  Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima M, Masaki T.  Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo  Int J Oncol  2015  46(6):2419-30  PubMed ID: 25823465   DOI: 10.3892/ijo.2015.2941
13709  Marquardt JU, Gomez-Quiroz L, Arreguin Camacho LO, Pinna F, Lee YH, Kitade M, Domínguez MP, Castven D, Breuhahn K, Conner EA, Galle PR, Andersen JB, Factor VM, Thorgeirsson SS.  Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer  J Hepatol  2015  63(3):661-9.  PubMed ID: 25937435   DOI: 10.1016/j.jhep.2015.04.018
14990  Jin H, Zhang Y, You H, Tao X, Wang C, Jin G, Wang N, Ruan H, Gu D, Huo X, Cong W, Qin W.  Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma  Sci Rep  2015  5:10466  PubMed ID: 26099564   DOI: 10.1038/srep10466
15002  Liu Q, Jung J, Somiya M, Iijima M, Yoshimoto N, Niimi T, Maturana AD, Shin SH, Jeong SY, Choi EK, Kuroda S.  Virosomes of hepatitis B virus envelope L proteins containing doxorubicin: synergistic enhancement of human liver-specific antitumor growth activity by radiotherapy  Int J Nanomedicine  2015  10:4159-72  PubMed ID: 26203243   DOI: 10.2147/IJN.S84295
15003  Zhang XF, Chao J, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Jiang SS, Chen CL, Zhang HX, Xia JC.  Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma  Oncotarget  2015  6(38):40920-33  PubMed ID: 26506518   DOI: 10.18632/oncotarget.5712
6329  Wang H, Wang B, Liao Q, An H, Li W, Jin X, Cui S, Zhao L.  Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma.  FEBS Lett  2014  588(3):503-8  PubMed ID: 24374343   DOI: 10.1016/j.febslet.2013.12.016
5844  Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.  1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.  Pharmacology  2013  91(5-6):339-45  PubMed ID: 23817168   DOI: 10.1159/000351747
6321  Wang H, Li W, Jin X, Cui S, Zhao L.  LIM and SH3 protein 1, a promoter of cell proliferation and migration, is a novel independent prognostic indicator in hepatocellular carcinoma.  Eur J Cancer. 2013   2013  49(4):974-83  PubMed ID: 23084841   DOI: 10.1016/j.ejca.2012.09.032
14199  Hagiwara K, Kishimoto S, Ishihara M, Koyama Y, Mazda O, Sato T.  In vivo gene transfer using pDNA/chitosan/chondroitin sulfate ternary complexes: influence of chondroitin sulfate on the stability of freeze-dried complexes and transgene expression in vivo  J Gene Med  2013  15(2):83-92  PubMed ID: 23307647   DOI: 10.1002/jgm.2694
12720  Hagiwara K, Nakata M, Koyama Y, Sato T.  The effects of coating pDNA/chitosan complexes with chondroitin sulfate on physicochemical characteristics and cell transfection  Biomaterials  2012  33(29):7251-60  PubMed ID: 22796168   DOI: 10.1016/j.biomaterials.2012.06.040
13722  Pan K, Liang XT, Zhang HK, Zhao JJ, Wang DD, Li JJ, Lian Q, Chang AE, Li Q, Xia JC.  Characterization of bridging integrator 1 (BIN1) as a potential tumor suppressor and prognostic marker in hepatocellular carcinoma  Mol Med  2012  18(1):507-18  PubMed ID: 22281836   DOI: 10.2119/molmed.2011.00319
7718  Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T.  Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate.  Cancer Sci.  2011  102:2000-6  PubMed ID: 21827582   DOI: 10.1111/j.1349-7006.2011.02060.x
7762  Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK.  EpCAM- and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber-modified adenovirus.  Int. J. Cancer  2011  129:1244-53  PubMed ID: 21710497   DOI: 10.1002/ijc.25758
7896  Goto K, Tatsumi K, Nagata T, Komizu Y, Ueoka R.  Specific interaction between Ca2+ and anionic lipids in cancer cells along with apoptosis.  Biol. Pharm. Bull.  2011  34:439-42  PubMed ID: 21372400   DOI: 10.1248/bpb.34.439
8252  Ma H, Liang X, Chen Y, Pan K, Sun J, Wang H, Wang Q, Li Y, Zhao J, Li J, Chen M, Xia J.  Decreased expression of BATF2 is associated with a poor prognosis in hepatocellular carcinoma.  Int. J. Cancer  2011  128:771-7  PubMed ID: 20473897   DOI: 10.1002/ijc.25407
15090  Yang D, Yaguchi T, Nakano T, Nishizaki T.  Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells  Cell Physiol Biochem  2011  27(1):71-8  PubMed ID: 21325824   DOI: 10.1159/000325207
8132  Tjeldhorn L, Iversen N, Sandvig K, Bergan J, Sandset PM, Skretting G.  Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.  BMC Cell Biol.  2010  11:67  PubMed ID: 20815936   DOI: 10.1186/1471-2121-11-67
8467  Nakahara Y, Imanishi S, Mitsumasu K, Kanamori Y, Iwata K, Watanabe M, Kikawada T, Okuda T.  Cells from an anhydrobiotic chironomid survive almost complete desiccation.  Cryobiology  2009  60:138-46  PubMed ID: 19850023   DOI: 10.1016/j.cryobiol.2009.10.004
8737  Suzuki T, Sakurai F, Nakamura S, Kouyama E, Kawabata K, Kondoh M, Yagi K, Mizuguchi H.  miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy.  Mol. Ther.  2008  16:1719-26  PubMed ID: 18665157   DOI: 10.1038/mt.2008.159
14931  Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y.  The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma  Lab Invest  2008  88(8):873-82  PubMed ID: 18591938   DOI: 10.1038/labinvest.2008.52
8798  Kikawada T, Saito A, Kanamori Y, Nakahara Y, Iwata K, Tanaka D, Watanabe M, Okuda T.  Trehalose transporter 1, a facilitated and high-capacity trehalose transporter, allows exogenous trehalose uptake into cells.  Proc. Natl. Acad. Sci. U.S.A.  2007  104:11585-90  PubMed ID: 17606922   DOI: 10.1073/pnas.0702538104
8828  Tanaka T, Takahashi M, Kusano E, Okamoto H.  Development and evaluation of an efficient cell-culture system for Hepatitis E virus.  J. Gen. Virol.  2007  88:903-11  PubMed ID: 17325363   DOI: 10.1099/vir.0.82535-0
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6505  Ikeda T, Saito T, Ushita M, Yano F, Kan A, Itaka K, Moro T, Nakamura K, Kawaguchi H, Chung UI.  Identification and characterization of the human SOX6 promoter.  Biochem Biophys Res Commun  2007  357(2):383-90  PubMed ID: 17433257   DOI: 10.1016/j.bbrc.2007.03.133
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