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Cell No. : Cell Name
RCB1366 : HuH-7  update : 2022/09/15
CommentSaid producing alpha-fetoprotein, alpha-antitrypsin, ceruloplasmin, fibrinogen, fibronectin, etc.
Comment from the depositor
Terms and conditionsA prior written permission of the approver(Depositor) is necessary for any kind of use including academic use and for-profit use.
approver's address
Okayama University Graduate School of Medicine
Dentistry, and Pharmaceutical Sciences, Department of Cell Biology
2-5-1 shikata-cho , Kita-ku , Okayama-shi, Okayama 700-8558 Japan
Fax. +81-86-235-7400
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Huh, Nam, Ho
Originator Nakabayashi, Hidekazu
Year of deposit 1997
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 57 years
Tissue liver
Disease name Hepatoma
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0336
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics 100U/ml Penicillin + 100μg/ml Streptomycin
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP, MPI, PepB
Chromosome mode 105-114(50) : 105(6),106(8),107(8),109(4),110(6)/
Reference information Reference 3
User's Publication 76

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3427  H Nakabayashi, K Taketa, T Yamane, M Oda, J Sato  Hormonal control of alpha-fetoprotein secretion in human hepatoma cell lines p  Cancer Res  1985  45(12 Pt 1):6379-83  PubMed ID: 2415243  
2578  Nakabayashi H, Taketa K, Yamane T, Miyazaki M, Miyano K, Sato J  Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium.  Gann  1984  75:151-8  PubMed ID: 6203805  
135  Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J  Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.  Cancer Res  1982  42:3858-63  PubMed ID: 6286115  

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User's Publication
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20327  Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Takasu C, Miyazaki K, Shimada M.  Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.  PLoS One  2021  16(9):e0256755  PubMed ID: 34473785   DOI: 10.1371/journal.pone.0256755
15515  Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.  A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment  Cancers (Basel)  2021  13(16):3997  PubMed ID: 34439154   DOI: 10.3390/cancers13163997
20399  Sun F, Liu Y, Gong T, Pan Q, Xiang T, Zhao J, Tang Y, Chen H, Han Y, Song M, Huang Y, Li H, Chen Y, Yang C, Yang J, Wang Q, Li Y, He J, Weng D, Peng R, Xia J.  Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin.  Cell Death Dis  2021  12(12):1093  PubMed ID: 34795209   DOI: 10.1038/s41419-021-04375-3
20488  Yanazawa K, Sugasawa T, Aoki K, Nakano T, Kawakami Y, Takekoshi K.  Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.  PeerJ  2021  9:e12285  PubMed ID: 34721976   DOI: 10.7717/peerj.12285
20506  Shidoji Y, Iwao C.  A rapid increase in lysophospholipids after geranylgeranoic acid treatment in human hepatoma-derived HuH-7 cells revealed by metabolomics analysis.  Biochem Biophys Rep  2021  28:101176  PubMed ID: 34869922   DOI: 10.1016/j.bbrep.2021.101176
16727  Munson MJ, O'Driscoll G, Silva AM, Lázaro-Ibáñez E, Gallud A, Wilson JT, Collén A, Esbjörner EK, Sabirsh A.  A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery  Commun Biol  2021  4(1):211  PubMed ID: 33594247   DOI: 10.1038/s42003-021-01728-8
16875  Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Okikawa S, Takasu C, Shimada M.  The BAFF/NFκB axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts  Cancer Sci  2021  112(9):3545-3554  PubMed ID: 34159680   DOI: 10.1111/cas.15041
17032  Kazuko KANEDA-NAKASHIMA, Zijian ZHANG, Kojiro NAGATA, Kenji SHIRASAKI, Hidetoshi KIKUNAGA, Tomoo YAMAMURA, Kazuhiro OOE, Tadashi WATABE, Atsushi TOYOSHIMA, Takashi YOSHIMURA, Atsushi SHINOHARA  Dispersion of Alpha-Nuclides during Animal Experiments  Radiation Safety Management  2021  20:29-38    DOI: 10.12950/rsm.210519
17033  Liu T, Yu J, Ge C, Zhao F, Miao C, Jin W, Su Y, Geng Q, Chen T, Xie H, Cui Y, Yao M, Li J, Hou H, Li H.  B-Cell Receptor-Associated Protein 31 Promotes Metastasis via AKT/β-Catenin/Snail Pathway in Hepatocellular Carcinoma  Front Mol Biosci  2021  8:656151  PubMed ID: 34179078   DOI: 10.3389/fmolb.2021.656151
12072  Yu Q, Dai J, Shu M.  Retraction: Hsa_circ_0003645 shows an oncogenic role by sponging microRNA-1299 in hepatocellular carcinoma cells.  J. Clin. Lab. Anal.  2020    PubMed ID: 32108372   DOI: 10.1002/jcla.23249
13454  Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh  Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro  Personalized Medicine Universe  2020      DOI: 10.46459/pmu.2020001
13537  Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, Qin W, Luo X, Hao Y.  COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling  J Exp Clin Cancer Res  2020  39(1):148  PubMed ID: 32746865   DOI: 10.1186/s13046-020-01650-7
14867  Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y, Han J, Duan Y.  Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity  J Hepatol  2020  73(6):1482-1495  PubMed ID: 32738448   DOI: 10.1016/j.jhep.2020.07.034
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11045  Haiqiu Wu, Cun Wang, Jiaxin Sun, Luyan Sun, Jiaxun Wan, Siying Wang, Dishui Gu, Chengtao Yu, Chen Yang, Jia He, Zihao Zhang, Yuanyuan Lv, Hui Wang, Ming Yao, Wenxin Qin, Changchun Wang, Haojie Jin  Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis  ACS Appl Mater Interfaces  2019  11(47):43996-44006  PubMed ID: 31682099   DOI: 10.1021/acsami.9b18086
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5844  Kanno T, Tanaka A, Shimizu T, Nakano T, Nishizaki T.  1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol as a potential anticancer drug.  Pharmacology  2013  91(5-6):339-45  PubMed ID: 23817168   DOI: 10.1159/000351747
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