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19797
Kurosawa M, Kato F, Hishiki T, Ito S, Fujisawa H, Yamaguchi T, Moriguchi M, Hosokawa K, Watanabe T, Saito-Tarashima N, Minakawa N, Fujimuro M.
Sofosbuvir Suppresses the Genome Replication of DENV1 in Human Hepatic Huh7 Cells
Int J Mol Sci
2024
25(4):2022
PubMed ID: 38396699
DOI: 10.3390/ijms25042022
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19864
Hori Y, Yoh T, Nishino H, Okura K, Kurimoto M, Takamatsu Y, Satoh M, Nishio T, Koyama Y, Ishii T, Iwaisako K, Seo S, Hatano E.
Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma
Carcinogenesis
2024
45(3):119-130
PubMed ID: 38123365
DOI: 10.1093/carcin/bgad094
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21541
Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, Li J, Zhu L, Keith B, Simon MC.
Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer.
Nat Cancer
2024
PubMed ID: 38168934
DOI: 10.1038/s43018-023-00671-3
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21676
Jinno R, Tanaka M, Komizu Y, Matsumoto Y, Matsushita T, Ishida S.
Selective elimination of tumorigenic cells from mixed culture of normal and tumorigenic cells using hybrid liposomes aimed at realizing of cell therapy.
Cytotechnology
2024
76(2):247-258
PubMed ID: 38495296
DOI: 10.1007/s10616-023-00613-y
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21730
Su Y, Meng L, Ge C, Liu Y, Zhang C, Yang Y, Tian W, Tian H.
PSMD9 promotes the malignant progression of hepatocellular carcinoma by interacting with c-Cbl to activate EGFR signaling and recycling.
J Exp Clin Cancer Res
2024
43(1):142
PubMed ID: 38745188
DOI: 10.1186/s13046-024-03062-3
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21754
Nagano S, Unuma K, Aki T, Uemura K.
N-acetylcysteine alleviates arsenic trioxide-induced reductions in hepatic catalase gene expression both in vitro and in vivo.
Leg Med (Tokyo)
2024
69:102458
PubMed ID: 38781725
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21976
Lotter C, Kuzucu EÜ, Casper J, Alter CL, Puligilla RD, Detampel P, Lopez JS, Ham AS, Huwyler J.
Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery.
Eur J Pharm Sci
2024
106898
PubMed ID: 39260517
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22051
Shinohara S, Uchijima S, Hirosawa K, Nagaoka M, Nakano M, Nakajima M, Fukami T.
Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis.
Arch Toxicol
2024
PubMed ID: 39367970
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22100
Zhang L, Dang N, Wang J, Zhang W, Hu X, Jiang B, Zhao D, Liu F, Yuan H.
ZNF143-mediated upregulation of MEX3C promotes hepatocellular carcinoma progression.
Clin Res Hepatol Gastroenterol
2024
102492
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22158
Degtev D, Bravo J, Emmanouilidi A, Zdravković A, Choong OK, Liz Touza J, Selfjord N, Weisheit I, Francescatto M, Akcakaya P, Porritt M, Maresca M, Taylor D, Sienski G.
Engineered PsCas9 enables therapeutic genome editing in mouse liver with lipid nanoparticles.
Nat Commun
2024
15(1):9173
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17740
Sagna A, Nair RVR, Hulyalkar N, Rajasekharan S, Nair VTG, Sivakumar KC, Suja SR, Baby S, Sreekumar E.
Ethyl palmitate, an anti-chikungunya virus principle from Sauropus androgynus, a medicinal plant used to alleviate fever in ethnomedicine
J Ethnopharmacol
2023
309:116366
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19733
Ito C, Haraguchi R, Ogawa K, Iwata M, Kitazawa R, Takada Y, Kitazawa S.
Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression
Histochem Cell Biol
2023
160(5):407-418
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21105
Chen J, Zhang J, Tian W, Ge C, Su Y, Li J, Tian H.
AKR1C3 suppresses ferroptosis in hepatocellular carcinoma through regulation of YAP/SLC7A11 signaling pathway.
Mol Carcinog
2023
PubMed ID: 36920042
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21114
Miyazaki K, Morine Y, Xu C, Nakasu C, Wada Y, Teraoku H, Yamada S, Saito Y, Ikemoto T, Shimada M, Goel A.
Curcumin-Mediated Resistance to Lenvatinib via EGFR Signaling Pathway in Hepatocellular Carcinoma.
Cells
2023
12(4)
PubMed ID: 36831279
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21118
Aki T, Kukita M, Takata M, Funakoshi T, Unuma K, Uemura K.
Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure.
Biochem Biophys Res Commun
2023
651:92-97
PubMed ID: 36801614
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21153
Yang W, Miyazaki T, Nakagawa Y, Boonstra E, Masuda K, Nakashima Y, Chen P, Mixich L, Barthelmes K, Matsumoto A, Mi P, Uchida S, Cabral H.
Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π-π stacking-assisted micellar assembly.
Sci Technol Adv Mater
2023
24(1):2170164
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21173
Sanchez-Moral L, Paul T, Martori C, Font-Díaz J, Sanjurjo L, Aran G, Téllez É, Blanco J, Carrillo J, Ito M, Tuttolomondo M, Ditzel HJ, Fumagalli C, Tapia G, Sidorova J, Masnou H, Fernández-Sanmartín MA, Lozano JJ, Vilaplana C, Rodriguez-Cortés A, Armengol C, Valledor AF, Kremer L, Sarrias MR.
Macrophage CD5L is a target for cancer immunotherapy.
EBioMedicine
2023
91:104555
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21253
Muranaka M, Takamatsu S, Ouchida T, Kanazawa Y, Kondo J, Nakagawa T, Egashira Y, Fukagawa K, Gu J, Okamoto T, Kamada Y, Miyoshi E.
Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells.
Int J Mol Sci
2023
24(8)
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21273
Tomihari A, Kiyota M, Matsuura A, Itakura E.
Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins.
Sci Rep
2023
13(1):4680
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21314
Liu K, Nilsson R, Lázaro-Ibáñez E, Duàn H, Miliotis T, Strimfors M, Lerche M, Salgado Ribeiro AR, Ulander J, Lindén D, Salvati A, Sabirsh A.
Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function.
Nat Commun
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14(1):4007
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21349
Zhou L, Wang Z, Chen X, Li X, Ge C, Min X, Zhao F, Chen T, Li J.
Syntaxin-6 promotes the progression of hepatocellular carcinoma and alters its sensitivity to chemotherapies by activating the USF2/LC3B axis.
Int J Biol Sci
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21354
Aki T, Tanaka H, Funakoshi T, Unuma K, Uemura K.
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells.
Biochem Biophys Res Commun
2023
676:66-72
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21392
Liu Q, Song Q, Luo C, Wei J, Xu Y, Zhao L, Wang Y.
A novel bispecific antibody as an immunotherapeutic agent in hepatocellular carcinoma.
Mol Immunol
2023
162:125-132
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21490
Su Y, Lin H, Yu J, Mao L, Jin W, Liu T, Jiang S, Wu Y, Zhang S, Geng Q, Ge C, Zhao F, Chen T, Cui Y, Li J, Hou H, Zhou X, Li H.
RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma.
J Exp Clin Cancer Res
2023
42(1):326
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20450
Castven D, Czauderna C, Becker D, Pereira S, Schmitt J, Weinmann A, Shah V, Hajduk J, Keggenhoff F, Binder H, Keck T, Heilmann-Heimbach S, Wörns MA, Thorgeirsson SS, Breuhahn K, Galle PR, Marquardt JU.
Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells.
Hepatol Commun
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20482
Bolatkan A, Asada K, Kaneko S, Suvarna K, Ikawa N, Machino H, Komatsu M, Shiina S, Hamamoto R.
Downregulation of METTL6 mitigates cell progression, migration, invasion and adhesion in hepatocellular carcinoma by inhibiting cell adhesion molecules.
Int J Oncol
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16230
Takahiro Arai, Yu Aiki, Toshinori Sato
Accelerated transgene expression of pDNA/polysaccharide complexes by solid-phase reverse transfection and analysis of the cell transfection mechanism
Polymer Journal
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Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines.
Food Chem Toxicol
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20615
Chen X, Wang Z, Zhao X, Zhang L, Zhou L, Li X, Ge C, Zhao F, Chen T, Xie H, Cui Y, Tian H, Li H, Yao M, Li J.
STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.
Oncogene
2022
PubMed ID: 35314791
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20639
Okikawa S, Morine Y, Saito Y, Yamada S, Tokuda K, Teraoku H, Miyazaki K, Yamashita S, Ikemoto T, Imura S, Shimada M.
Inhibition of the VEGF signaling pathway attenuates tumor‑associated macrophage activity in liver cancer.
Oncol Rep
2022
47(4)
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20707
Yamasaki Y, Kumekawa D, Yamauchi S, Omuro H.
Re-examination of Peptide-Sequence-Dependent Gene Expression of Cysteine-Installed Pegylated Oligolysine/DNA Complexes.
ACS Omega
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20828
Arai T, Sato T, Matsubara T.
Effective Cell Transfection in An Ultrasonically Levitated Droplet for Sustainable Technology.
Adv Sci (Weinh)
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20901
Samadaei M, Senfter D, Madlener S, Uranowska K, Hafner C, Trauner M, Rohr-Udilova N, Pinter M.
Targeting DNA repair to enhance the efficacy of sorafenib in hepatocellular carcinoma.
J Cell Biochem
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PubMed ID: 36271841
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21983
Hu X, Roy SR, Jin C, Li G, Zhang Q, Asano N, Asahina S, Kajiwara T, Takahara A, Feng B, Aoki K, Xu C, Zhang Y.
Control cell migration by engineering integrin ligand assembly.
Nat Commun
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Feng R, Cui Z, Liu Z, Zhang Y.
Upregulated microRNA-132 in T helper 17 cells activates hepatic stellate cells to promote hepatocellular carcinoma cell migration in vitro.
Scand J Immunol
2021
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Yoshinaga N, Uchida S, Dirisala A, Naito M, Osada K, Cabral H, Kataoka K.
mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency.
J Control Release
2021
330:317-328
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Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.
The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinoma.
Oncotarget
2021
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20136
El-Mezayen H, Yamamura K, Yusa T, Nakao Y, Uemura N, Kitamura F, Itoyama R, Yamao T, Higashi T, Hayashi H, Imai K, Chikamoto A, Yamashita YI, Baba H.
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma.
Ann Surg Oncol
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Yugawa K, Itoh S, Yoshizumi T, Iseda N, Tomiyama T, Morinaga A, Toshima T, Harada N, Kohashi K, Oda Y, Mori M.
CMTM6 Stabilizes PD-L1 Expression and Is a New Prognostic Impact Factor in Hepatocellular Carcinoma.
Hepatol Commun
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Development of Covalent Chitosan-Polyethylenimine Derivatives as Gene Delivery Vehicle: Synthesis, Characterization, and Evaluation.
Int J Mol Sci
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Wang S, Lv Y, Zhou Y, Ling J, Wang H, Gu D, Wang C, Qin W, Zheng X, Jin H.
Acidic extracellular pH induces autophagy to promote anoikis resistance of hepatocellular carcinoma cells via downregulation of miR-3663-3p.
J Cancer
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Chen S, Morine Y, Tokuda K, Yamada S, Saito Y, Nishi M, Ikemoto T, Shimada M.
Cancer‑associated fibroblast‑induced M2‑polarized macrophages promote hepatocellular carcinoma progression via the plasminogen activator inhibitor‑1 pathway.
Int J Oncol
2021
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Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK.
J Gen Virol
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Czauderna C, Poplawski A, O Rourke CJ, Castven D, Pérez-Aguilar B, Becker D, Heilmann-Heimbach S, Odenthal M, Amer W, Schmiel M, Drebber U, Binder H, Ridder DA, Schindeldecker M, Straub BK, Galle PR, Andersen JB, Thorgeirsson SS, Park YN, Marquardt JU.
Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesis.
JCI Insight
2021
PubMed ID: 34375307
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Yoshinaga N, Naito M, Tachihara Y, Boonstra E, Osada K, Cabral H, Uchida S.
PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials.
Pharmaceutics
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Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Takasu C, Miyazaki K, Shimada M.
Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells.
PLoS One
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Qiu R, Murata S, Cheng C, Mori A, Nie Y, Mikami S, Hasegawa S, Tadokoro T, Okamoto S, Taniguchi H.
A Novel Orthotopic Liver Cancer Model for Creating a Human-like Tumor Microenvironment
Cancers (Basel)
2021
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20399
Sun F, Liu Y, Gong T, Pan Q, Xiang T, Zhao J, Tang Y, Chen H, Han Y, Song M, Huang Y, Li H, Chen Y, Yang C, Yang J, Wang Q, Li Y, He J, Weng D, Peng R, Xia J.
Inhibition of DTYMK significantly restrains the growth of HCC and increases sensitivity to oxaliplatin.
Cell Death Dis
2021
12(12):1093
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Yanazawa K, Sugasawa T, Aoki K, Nakano T, Kawakami Y, Takekoshi K.
Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice.
PeerJ
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Shidoji Y, Iwao C.
A rapid increase in lysophospholipids after geranylgeranoic acid treatment in human hepatoma-derived HuH-7 cells revealed by metabolomics analysis.
Biochem Biophys Rep
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28:101176
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16727
Munson MJ, O'Driscoll G, Silva AM, Lázaro-Ibáñez E, Gallud A, Wilson JT, Collén A, Esbjörner EK, Sabirsh A.
A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery
Commun Biol
2021
4(1):211
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Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Miyazaki K, Okikawa S, Takasu C, Shimada M.
The BAFF/NFκB axis is crucial to interactions between sorafenib-resistant HCC cells and cancer-associated fibroblasts
Cancer Sci
2021
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Kazuko KANEDA-NAKASHIMA, Zijian ZHANG, Kojiro NAGATA, Kenji SHIRASAKI, Hidetoshi KIKUNAGA, Tomoo YAMAMURA, Kazuhiro OOE, Tadashi WATABE, Atsushi TOYOSHIMA, Takashi YOSHIMURA, Atsushi SHINOHARA
Dispersion of Alpha-Nuclides during Animal Experiments
Radiation Safety Management
2021
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Liu T, Yu J, Ge C, Zhao F, Miao C, Jin W, Su Y, Geng Q, Chen T, Xie H, Cui Y, Yao M, Li J, Hou H, Li H.
B-Cell Receptor-Associated Protein 31 Promotes Metastasis via AKT/β-Catenin/Snail Pathway in Hepatocellular Carcinoma
Front Mol Biosci
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J. Clin. Lab. Anal.
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Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh
Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro
Personalized Medicine Universe
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Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, Qin W, Luo X, Hao Y.
COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling
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39(1):148
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Zhang S, Guo F, Yu M, Yang X, Yao Z, Li Q, Wei Z, Feng K, Zeng P, Zhao D, Li X, Zhu Y, Miao QR, Iwakiri Y, Chen Y, Han J, Duan Y.
Reduced Nogo expression inhibits diet-induced metabolic disorders by regulating ChREBP and insulin activity
J Hepatol
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Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A
Anticancer Res
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Haiqiu Wu, Cun Wang, Jiaxin Sun, Luyan Sun, Jiaxun Wan, Siying Wang, Dishui Gu, Chengtao Yu, Chen Yang, Jia He, Zihao Zhang, Yuanyuan Lv, Hui Wang, Ming Yao, Wenxin Qin, Changchun Wang, Haojie Jin
Self-Assembled and Self-Monitored Sorafenib/Indocyanine Green Nanodrug with Synergistic Antitumor Activity Mediated by Hyperthermia and Reactive Oxygen Species-Induced Apoptosis
ACS Appl Mater Interfaces
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Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma
Acta Biochim Biophys Sin (Shanghai)
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Tsuchiya H, Oura S.
Involvement of MAFB and MAFF in Retinoid-Mediated Suppression of Hepatocellular Carcinoma Invasion
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Antidyslipidemic potential of a novel farnesoid X receptor antagonist in a hamster model of dyslipidemia: Comparative studies of other nonstatin agents
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uppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB
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