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Cell No. : Cell Name
RCB1313 : RERF-LC-KJ  update : 2021/05/20
CommentJapanese lung adenocarcinoma, highly metastatic in SCID mice. Also refer to RCB0444 RCRF-LC-AI.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Kyoizumi, Seishi
Originator Terada, Seigo
Year of deposit 1997
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 78 years
Tissue lung
Disease name adenocarcinoma
Metastastatic ability Yes
Classification cancer
Year of origin 1992
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1654
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/7-10 days, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
Chromosome mode 59-70(50) : /64(7),65(5),66(6),67(6),68(8),69(8)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 2
User's Publication 21


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Reference
2209  Teraoka S, Kyoizumi S, Seyama T, Yamakido M, Akiyama M  A Novel SCID Mouse Model for Studying Spontaneous Metastasis of Human Lung Cancer to Human Tissue  Jpn J Cancer Res  1995  86:419-423  PubMed ID: 7790314
2208  Teraoka, S., Kyoizumi, S., Seyama, T., Yamakido, M., and Akiyama, M.  SCID mice model for the in vivo study of human oncothetapy: Studies on the growth and metastasis of human lung cancer  Int J Oncol  1994  5:501-508  PubMed ID: 21559605

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User's Publication
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667
13773  Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H, Yamamoto M.  Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites  Cancer Sci  2020  111(2):667-678  PubMed ID: 31828882
11336  Kosibaty Z, Murata Y, Minami Y, Dai T, Kano J, Matsuoka R, Nakano N, Noguchi M.  Cytoplasmic expression of epithelial cell transforming sequence 2 in lung adenocarcinoma and its implications for malignant progression.  Lab. Invest.  2019    PubMed ID: 30542068
11379  Omoto K, Matsuda R, Nakai Y, Tatsumi Y, Nakazawa T, Tanaka Y, Shida Y, Murakami T, Nishimura F, Nakagawa I, Motoyama Y, Nakamura M, Fujimoto K, Hiroyuki N.  Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.  Photodiagnosis Photodyn Ther  2019    PubMed ID: 30639584
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2017  8:2890-2905  PubMed ID: 27926516
10280  Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A.  AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier.  Oncol. Rep.  2017  37:3261-3269  PubMed ID: 28440492
10922  Shigeaki Umeda et al  Loss of IL-24 expression facilitates invasion in lung adenocarcinoma   Int J Clin Exp Pathol  2017  10:173-185 
14355  Okita R, Maeda A, Shimizu K, Nojima Y, Saisho S, Nakata M.  PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer  Cancer Immunol Immunother   2017  66(7):865-876  PubMed ID: 28341875
9522  Nishijima N, Seike M, Soeno C, Chiba M, Miyanaga A, Noro R, Sugano T, Matsumoto M, Kubota K, Gemma A.  miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.  Int. J. Oncol.  2016  48:937-44  PubMed ID: 26783187
12967  Okita R, Yukawa T, Nojima Y, Maeda A, Saisho S, Shimizu K, Nakata M.  MHC class I chain-related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non-small cell lung cancer  Cancer Immunol Immunother  2016  65(5):499-509.  PubMed ID: 26940474
13810  Chen S, Huang L, Sun K, Wu D, Li M, Li M, Zhong B, Chen M, Zhang S.  Enhancer of zeste homolog 2 as an independent prognostic marker for cancer: a meta-analysis  PLoS One  2015  10(5):e0125480  PubMed ID: 25974088
14314  Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E, Lundqvist A, Kiessling R, Seliger B, Nakata M.  Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells  PLoS One  2015  10(10):e0139809  PubMed ID: 26439264
6398  Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S  Eph receptor A10 has a potential as a target for a prostate cancer therapy.  Biochem Biophys Res Commun  2014  450(1):545-9  PubMed ID: 24924629
13754  Narita K, Matsuda Y, Seike M, Naito Z, Gemma A, Ishiwata T.  Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma  Int J Oncol   2014  44(4):1118-30  PubMed ID: 24481417
7714  Huqun, Ishikawa R, Zhang J, Miyazawa H, Goto Y, Shimizu Y, Hagiwara K, Koyama N.  Enhancer of zeste homolog 2 is a novel prognostic biomarker in nonsmall cell lung cancer.  Cancer  2012  118:1599-606  PubMed ID: 21837672
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309
13878  Tanaka Y, Goto K, Matsumoto Y, Ueoka R.  Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis  Int J Pharm  2008  359(1-2):264-71  PubMed ID: 18511224
3061  Nagai, Yoshiaki, Miyazawa, Hitoshi, Tanaka, Tomoaki, Udagawa, Kiyoshi, Kato, Motoyasu, Fukuyama, Shunichiro, Yokote, Akemi, Kobayashi, Kunihiko, Kanazawa, Minoru, Hagiwara, Koichi, Hagiwara K  Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.  Cancer Res  2005  65:7276-82  PubMed ID: 16105816
13836  Murai Y, Hayashi S, Takahashi H, Tsuneyama K, Takano Y.  Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines  Pathol Res Pract  2005  201(2):109-15  PubMed ID: 15901131
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251
12847  Ishii T, Teramoto S, Matsuse T.  GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells  Cancer Lett  2004  216(1):89-102  PubMed ID: 15500952



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