Cell No. : Cell Name RCB1293 : SSP-25  update : 2020/09/24
Comment			Human intrahepatic cholangiocarcinoma. Please read carefully this information before use.
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, a prior written permission of the DEPOSITOR or the RIKEN BRC is necessary.
Remarks
Order Form			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
	Basic information	Depositor	Enjoji, Munechika
		Originator	Enjoji, Munechika
		Year of deposit	1996
		Animal	human < Mammals
		Genus	Homo
		Species	sapiens
		Race	Japanese
		Gender	Female
		Tissue	liver
		Case history	cholangiocarcinoma
		Classification	cancer
		Lifespan	infinite
		Morphology	fibroblast-like
			deposit info	lot info
		Medium	Medium List
		Medium and additives		RPMI1640 + 10% FBS
		Antibiotics		Free
		Passage method		0.25% trypsin
	Culture information	Passage ratio		1 : 8 split
		SC frequency		Subculture : once/week, Medium Renewal : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Virus (HBV)		(-)
		Virus (HCV)		(-)
		Isozyme		LD, NP
		Chromosome mode		57-64(50) : /58(2),59(3),60(27),61(6),62(8),63(2)/
Images			deposit info	lot info
Reference information		Reference	0
		User's Publication	17

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Reference

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User's Publication

12014  Somchai P, Phongkitkarun K, Kueanjinda P, Jamnongsong S, Vaeteewoottacharn K, Luvira V, Okada S, Jirawatnotai S, Sampattavanich S.  Novel Analytical Platform For Robust Identification of Cell Migration Inhibitors.  Sci Rep  2020    PubMed ID: 31969633

11220  You HL, Liu TT, Weng SW, Chen CH, Wei YC, Eng HL, Huang WT.  Association of IRS2 overexpression with disease progression in intrahepatic cholangiocarcinoma.  Oncol Lett  2018    PubMed ID: 30250623

4347  Lin HY, Tey SL, Ho Y, Chin YT, Wang K, Whang-Peng J, Shih YJ, Chen YR, Yang YN, Chen YC, Liu YC, Tang HY, Yang YS.  Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-β Pathway.  Mar Drugs  2018    PubMed ID: 30563284

10290  Quintavalle C, Burmeister K, Piscuoglio S, Quagliata L, Karamitopoulou E, Sepe R, Fusco A, Terracciano LM, Andersen JB, Pallante P, Matter MS.  High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy.  Mol. Carcinog.  2017  56:2146-2157  PubMed ID: 28467612

10333  Huang G-, Liu TT, Weng SW, You HL, Wei YC, Chen CH, Eng HL, Huang WT.  CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma.  BMC Cancer  2017  17:395  PubMed ID: 28576144

9871  Hoshino H, Ohta M, Ito M, Uchimura K, Sakai Y, Uehara T, Low S, Fukushima M, Kobayashi M.  Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma.  Lab. Invest.  2016  96:1246-1255  PubMed ID: 27748735

3735  Saha SK et al  Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.  Cancer Discov  2016  6(7):727-39  PubMed ID: 27231123

5025  Sakamoto K, Imai K, Higashi T, Taki K, Nakagawa S, Okabe H, Nitta H, Hayashi H, Chikamoto A, Ishiko T, Beppu T, Baba H.  Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer.  Cancer Sci  2015  106(9):1153-62  PubMed ID: 26132727

9170  Sheng-Huei Yang 1, Hung-Yun Lin, Vincent H S Chang, Chien-Chung Chen, Yun-Ru Liu, Jinghan Wang, Keqiang Zhang, Xiaoqing Jiang, Yun Yen  Lovastatin Overcomes Gefitinib Resistance Through TNF-α Signaling in Human Cholangiocarcinomas With Different LKB1 Statuses in Vitro and in Vivo  Oncotarget  2015  6 (27), 23857-73  PubMed ID: 26160843

8365  Ishii T, Yasuchika K, Suemori H, Nakatsuji N, Ikai I, Uemoto S.  Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma.  Cancer Lett.  2010  294:25-34  PubMed ID: 20149523

6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309

3575  Komori J, Marusawa H, Machimoto T, Endo Y, Kinoshita K, Kou T, Haga H, Ikai I, Uemoto S, Chiba T.  Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.  Hepatology  2008  47(3):888-96  PubMed ID: 18306229

3335  Yoshino K, Iimura E, Saijo K, Iwase S, Fukami K, Ohno T, Obata Y, Nakamura Y.  Essential role for gene profiling analysis in the authentication of human cell lines.  Hum Cell  2006  19(1):43-8  PubMed ID: 16643607

3077  Nakatsu N, Yoshida Y, Yamazaki K, Nakamura T, Dan S, Fukui Y, Yamori T  Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.  Mol Cancer Ther  2005  4:399-412  PubMed ID: 15767549

3334  Obama, Kazutaka, Ura, Katsuaki, Satoh, Seiji, Nakamura, Yusuke, Furukawa, Yoichi  Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma  Oncol Res  2005  14:701-706  PubMed ID: 16077978

3346  Yokoo, Hideki, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Todo, Satoru, Hirohashi, Setsuo  Proteomic signature corresponding to alpha fetoprotein expression in liver cancer cells.  Hepatology  2004  40:609-17  PubMed ID: 15349899

3703  Sanada T, Yokoi S, Arii S, Yasui K, Imoto I, Inazawa J.  Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers.  Cancer Sci  2004  95(12):969-76  PubMed ID: 15596046