細胞番号 : 細胞名
RCB1279 : TtT/GF
update : 2022/08/18
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| 細胞特性(Comment:英) | Mouse cell line derived from pituitary tumor (thyrotropin-producing tumor). Pituitary folliculo-stellate-like cells. FGF-dependent cell line. GFAP positive. S-100 positive. Said producing IL-6. |
| 細胞特性(日) | マウス下垂体腫瘍（甲状腺刺激ホルモン産生腫瘍）由来細胞株。濾胞星状細胞様細胞。FGF依存性。GFAP陽性。S-100陽性。IL-6産生性といわれている。 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Inoue, Kinji
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| 樹立者 |
Inoue, Kinji
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| 寄託日 |
1996
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| 動物種 |
_mouse
< Mammals
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| 採取組織 |
pituitary
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| 細胞分類 |
semi-normal
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細胞寿命 |
infinite
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| 細胞形態 |
epithelial-like
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| Cellosaurus(Expasy) |
CVCL_S512
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Adherent cells
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| 培地 |
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DMEM/HamF12 + 2.5% FBS + 10% HS (GIBCO)
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| 抗生物質 |
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Free
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継代方法 |
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0.25% Trypsin
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継代密度 |
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1 : 4 split
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| 継代・培地交換頻度 |
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Subculture : once/week, Medium Renewal : 2 times/week
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| 培養最適温度 |
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37
℃
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| 二酸化炭素濃度 |
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5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ/アコレプラズマ |
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(-)
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| マウス系統検査 |
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OK
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| アイソザイム検査 |
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LD, NP
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| 画像情報 |
寄託時情報 | ロット情報 |
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| 文献情報 |
Reference(英) |
8件
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| Reference(日) |
0件
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| 利用者成果(英) |
5件
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| 利用者成果(日) |
0件
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| Reference(英) |
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3325
T Yamasaki, H Fujita, K Inoue, T Fujita, N Yamashita
Regulation of K+ channels by cell contact in a cloned folliculo-stellate cell (TtT/GF)
Endocrinology
1997
138(10):4346-50.
PubMed ID: 9322949
DOI: 10.1210/endo.138.10.5445
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3326
U Renner, J Gloddek, E Arzt, K Inoue, G K Stalla
Interleukin-6 is an autocrine growth factor for folliculostellate-like TtT/GF mouse pituitary tumor cells
Exp Clin Endocrinol Diabetes
1997
105(6):345-52
PubMed ID: 9439931
DOI: 10.1055/s-0029-1211777
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3328
H Kobayashi, J Fukata, N Murakami, T Usui, O Ebisui, S Muro, I Hanaoka, K Inoue, H Imura, K Nakao
Tumor necrosis factor receptors in the pituitary cells
Brain Res
1997
758(1-2):45-50
PubMed ID: 9203532
DOI: 10.1016/s0006-8993(96)01437-0
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3298
Z X Zhang, K Koike, Y Sakamoto, H Jikihara, Y Kanda, K Inoue, K Hirota, A Miyake
Pituitary folliculo-stellate-like cell line produces a cytokine-induced neutrophil chemoattractant
Neuropeptides
1997
31(1):46-51
PubMed ID: 9574837
DOI: 10.1016/s0143-4179(97)90019-6
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3420
Chiaki Koyama, Hirokazu Matsumoto, Takafumi Sakai, Katsumi Wakabayashi, Akihiro Ito, Ernest F. Couch, Kinji Inoue
Pituitary Folliculo-Stellate-Like Cells Stimulate Somatotroic Pituitary Tumor Growth in Nude Mice
Endocr Pathol
1995
6(1):67-75
PubMed ID: 12114691
DOI: 10.1007/BF02914990
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2111
Matsumoto H, Ishibashi Y, Ohtaki T, Hasegawa Y, Koyama C, Inoue K
Newly established murine pituitary folliculo-stellate-like cell line (TtT/GF) secretes potent pituitary glandular cell survival factors, one of which corresponds to metalloproteinase inhibitor.
Biochem Biophys Res Commun
1993
194:909-15
PubMed ID: 8343172
DOI: 10.1006/bbrc.1993.1907
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2112
Matsumoto H, Koyama C, Sawada T, Koike K, Hirota K, Miyake A, Arimura A, Inoue K
Pituitary folliculo-stellate-like cell line (TtT/GF) responds to novel hypophysiotropic peptide (pituitary adenylate cyclase-activating peptide), showing increased adenosine 3',5'-monophosphate and interleukin-6 secretion and cell proliferation.
Endocrinology
1993
133:2150-5
PubMed ID: 8404665
DOI: 10.1210/endo.133.5.8404665
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2110
Inoue K, Matsumoto H, Koyama C, Shibata K, Nakazato Y, Ito A
Establishment of a folliculo-stellate-like cell line from a murine thyrotropic pituitary tumor.
Endocrinology
1992
131:3110-6
PubMed ID: 1446645
DOI: 10.1210/endo.131.6.1446645
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| 利用者成果(英) |
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21575
Mitsutani M, Matsushita M, Yokoyama M, Morita A, Hano H, Fujikawa T, Tagami T, Moriyama K.
Growth hormone directly stimulates GATA2 expression.
Growth Horm IGF Res
2024
74:101572
PubMed ID: 38281404
DOI: 10.1016/j.ghir.2024.101572
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11301
Hannen R, Steffani M, Voellger B, Carl B, Wang J, Bartsch JW, Nimsky C.
Effects of anti-estrogens on cell invasion and survival in pituitary adenoma cells: A systematic study.
J. Steroid Biochem. Mol. Biol.
2019
PubMed ID: 30439415
DOI: 10.1016/j.jsbmb.2018.11.005
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12580
Stella Tran, Ying Wang, Pankaj Lamba, Xiang Zhou, Ulrich Boehm, Daniel J Bernard
The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells
PLoS One
2013
8(10):e76642
PubMed ID: 24098544
DOI: 10.1371/journal.pone.0076642
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12578
Y Kiriyama, H Tsuchiya, T Murakami, K Satoh, Y Tokumitsu
Calcitonin induces IL-6 production via both PKA and PKC pathways in the pituitary folliculo-stellate cell line
Endocrinology
2001
142(8):3563-9
PubMed ID: 11459804
DOI: 10.1210/endo.142.8.8328
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12577
T Katayama, M Nakashima, H Kyan, N Murakami, H Kuroda
A role of pituitary adenylate cyclase activating polypeptide (PACAP) as a regulator of paracrine interactions between folliculo-stellate cells and gonadotropes through the control of activin-follistatin interactions
J Vet Med Sci
2000
62(7):731-6
PubMed ID: 10945291
DOI: 10.1292/jvms.62.731
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