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細胞番号 : 細胞名
RCB1193 : COLO-320  update : 2024/03/27
細胞特性(Comment:英)Described to produce serotonin, epinephrine. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 144 prior to order.
細胞特性(日)セロトニン、エピネフリンを作るという大腸癌細胞。DSMZとの交換細胞株。使用条件等が DSMZによって随時変更となる可能性があります。ご購入前に、ACC 144 を必ずご参照ください。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 144 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)1) 基礎的研究につきましては、使用制限はありません。しかし、使用条件等がDSMZによって随時変更となる可能性があるので、購入前に、ACC 144を必ず参照すること。2) 商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 DSMZ
寄託日 1995
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Female
55 years
採取組織 colon
病名 colon adenocarcinoma
細胞分類 cancer
入手歴 overseas, DSM (ACC 144)
細胞寿命 infinite
細胞形態 other
Cellosaurus(Expasy) CVCL_1989
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP
染色体検査 46-89(50) : 46(4),47(2),48(2),49(5),50(11),51(11)/
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 1件
Reference(日) 0件
利用者成果(英) 31件
利用者成果(日) 0件

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Reference(英)
2042  Quinn, L A, Moore, G E, Morgan, R T, Woods, L K  Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.  Cancer Res  1979  39:4914-24  PubMed ID: 498117  

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Reference(日)

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19943  Koyama Y, Fujihara S, Chiyo T, Matsui T, Hamaya S, Fujita K, Tani J, Morishita A, Kobara H, Ono M, Iwama H, Masaki T.  Role of Mir-452-5p Overexpression in Epithelial-Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer  In Vivo  2023  37(5):1980-1990  PubMed ID: 37652512   DOI: 10.21873/invivo.13295
19975  Aiba T, Hijiya N, Akagi T, Tsukamoto Y, Hirashita Y, Kinoshita K, Uchida T, Nakada C, Kurogi S, Ueda Y, Shiroshita H, Shiraishi N, Murakami K, Inomata M, Moriyama M.  Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis  Pathobiology  2023  Oct 5  PubMed ID: 37797604   DOI: 10.1159/000533877
21181  Liu C, Kudo T, Ye X, Gascoigne K.  Cell-to-cell variability in Myc dynamics drives transcriptional heterogeneity in cancer cells.  Cell Rep  2023  42(4):112401  PubMed ID: 37060565   DOI: 10.1016/j.celrep.2023.112401
17578  Mitani Y, Ohashi S, Kikuchi O, Nakai Y, Ida T, Mizumoto A, Yamamoto Y, Saito T, Kataoka S, Matsubara J, Yamada A, Kanai M, Matsumoto S, Sakai H, Yoshikawa K, Nakamura E, Muto M.  HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function  Sci Rep  2022  12(1):9213  PubMed ID: 35654814   DOI: 10.1038/s41598-022-13189-y
20610  Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H.  TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition.  Biochem Biophys Rep  2022  30:101239  PubMed ID: 35252596   DOI: 10.1016/j.bbrep.2022.101239
18212  Hiraide S, Takahashi M, Yoshida Y, Yamada H, Komine K, Ishioka C.  Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer  Cancer Sci  2021  112(9):3856-3870  PubMed ID: 34288281   DOI: 10.1111/cas.15075
15080  Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K.  Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells  Lab Invest  2021  101(8):1036-1047  PubMed ID: 33911189   DOI: 10.1038/s41374-021-00590-w
6918  Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.  Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.  Cell Chem Biol  2020  27(2):186-196  PubMed ID: 31813846   DOI: 10.1016/j.chembiol.2019.11.010
13234  Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.  Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32977947   DOI: 10.1016/j.bbrc.2020.09.007
13502  Nambara S, Masuda T, Kobayashi Y, Sato K, Tobo T, Koike K, Noda M, Ogawa Y, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Mimori K.  GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer  Cancer Sci  2020  111(2):343-355  PubMed ID: 31758608   DOI: 10.1111/cas.14248
11625  Kurosawa N, Wakata Y, Ida K, Midorikawa A, Isobe M.  High throughput development of TCR-mimic antibody that targets survivin-2B80-88/HLA-A*A24 and its application in a bispecific T-cell engager.  Sci Rep  2019    PubMed ID: 31285464   DOI: 10.1038/s41598-019-46198-5
11281  Suehiro Y, Takemoto Y, Nishimoto A, Ueno K, Shirasawa B, Tanaka T, Kugimiya N, Suga A, Harada E, Hamano K.  Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer.  Anticancer Res.  2018    PubMed ID: 30396941   DOI: 10.21873/anticanres.12977
4178  Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada C, Akagi T, Etoh T, Iha H, Inomata M, Takekawa M, Moriyama M.  Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.  Cancer Sci.  2018    PubMed ID: 29150975   DOI: 10.1111/cas.13444
10185  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773   DOI: 10.1038/bjc.2017.65
12615  Tokunaga R, Sakamoto Y, Nakagawa S, Miyake K, Izumi D, Kosumi K, Taki K, Higashi T, Imamura Y, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.  The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer  Ann Surg Oncol  2016  23(2):678-85  PubMed ID: 26416711   DOI: 10.1245/s10434-015-4879-3
14105  Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M.  SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer  Cancer Sci  2016  107(5):619-28  PubMed ID: 26892864   DOI: 10.1111/cas.12909
15077  Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt-Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R.  Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer  Gut  2016  65(8):1296-305  PubMed ID: 26001389   DOI: 10.1136/gutjnl-2014-309026
10157  Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano  The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells  J Cell Mol Med  2015  19(7):1569-81  PubMed ID: 25689483   DOI: 10.1111/jcmm.12531
10158  Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida  Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer  Mol Clin Oncol  2015  3(5):1080-1084  PubMed ID: 26623054   DOI: 10.3892/mco.2015.577
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
15897  Nishimoto A, Kugimiya N, Hosoyama T, Enoki T, Li TS, Hamano K.  HIF-1α activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells  Int J Oncol  2014  44(6):2077-84  PubMed ID: 24718784   DOI: 10.3892/ijo.2014.2367
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
7596  Suzuki S, Yamayoshi Y, Nishimuta A, Tanigawara Y.  S100A10 protein expression is associated with oxaliplatin sensitivity in human colorectal cancer cells.  Proteome Sci  2011  9:76  PubMed ID: 22206547   DOI: 10.1186/1477-5956-9-76
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
8700  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399   DOI: 10.1271/bbb.80324
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405   DOI: 10.1021/jf8020877
8757  Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.  Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.  Biol. Pharm. Bull.  2008  31:949-54  PubMed ID: 18451525   DOI: 10.1248/bpb.31.949
15636  Sasaki H, Miura K, Horii A, Kaneko N, Fujibuchi W, Kiseleva L, Gu Z, Murata Y, Karasawa H, Mizoi T, Kobayashi T, Kinouchi M, Ohnuma S, Yazaki N, Unno M, Sasaki I.  Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer  Cancer Sci  2008  99(4):711-9  PubMed ID: 18307535   DOI: 10.1111/j.1349-7006.2008.00725.x
15084  Maeda O, Kondo M, Fujita T, Usami N, Fukui T, Shimokata K, Ando T, Goto H, Sekido Y.  Enhancement of GLI1-transcriptional activity by beta-catenin in human cancer cells  Oncol Rep  2006  16(1):91-6  PubMed ID: 16786128  
3214  Hayashida, Yasuharu, Honda, Kazufumi, Idogawa, Masashi, Ino, Yoshinori, Ono, Masaya, Tsuchida, Akihiko, Aoki, Tatsuya, Hirohashi, Setsuo, Yamada, Tesshi  E-cadherin regulates the association between beta-catenin and actinin-4.  Cancer Res  2005  65:8836-45  PubMed ID: 16204054   DOI: 10.1158/0008-5472.CAN-05-0718
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251   DOI: 10.1002/pmic.200300795

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