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Cell No. : Cell Name
RCB1193 : COLO-320  update : 2024/09/10
CommentDescribed to produce serotonin, epinephrine. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 144 prior to order.
Comment from the depositor
Terms and conditions1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 144 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor DSMZ
Year of deposit 1995
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 55 years
Tissue colon
Disease name colon adenocarcinoma
Classification cancer
History overseas, DSM (ACC 144)
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_1989
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Isozyme LD, NP
Chromosome mode 46-89(50) : 46(4),47(2),48(2),49(5),50(11),51(11)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 32


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Reference
2042  Quinn, L A, Moore, G E, Morgan, R T, Woods, L K  Cell lines from human colon carcinoma with unusual cell products, double minutes, and homogeneously staining regions.  Cancer Res  1979  39:4914-24  PubMed ID: 498117  

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User's Publication
19943  Koyama Y, Fujihara S, Chiyo T, Matsui T, Hamaya S, Fujita K, Tani J, Morishita A, Kobara H, Ono M, Iwama H, Masaki T.  Role of Mir-452-5p Overexpression in Epithelial-Mesenchymal Transition (EMT) in Early-stage Colorectal Cancer  In Vivo  2023  37(5):1980-1990  PubMed ID: 37652512   DOI: 10.21873/invivo.13295
19975  Aiba T, Hijiya N, Akagi T, Tsukamoto Y, Hirashita Y, Kinoshita K, Uchida T, Nakada C, Kurogi S, Ueda Y, Shiroshita H, Shiraishi N, Murakami K, Inomata M, Moriyama M.  Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis  Pathobiology  2023  Oct 5  PubMed ID: 37797604   DOI: 10.1159/000533877
21181  Liu C, Kudo T, Ye X, Gascoigne K.  Cell-to-cell variability in Myc dynamics drives transcriptional heterogeneity in cancer cells.  Cell Rep  2023  42(4):112401  PubMed ID: 37060565   DOI: 10.1016/j.celrep.2023.112401
17578  Mitani Y, Ohashi S, Kikuchi O, Nakai Y, Ida T, Mizumoto A, Yamamoto Y, Saito T, Kataoka S, Matsubara J, Yamada A, Kanai M, Matsumoto S, Sakai H, Yoshikawa K, Nakamura E, Muto M.  HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function  Sci Rep  2022  12(1):9213  PubMed ID: 35654814   DOI: 10.1038/s41598-022-13189-y
19501  Yoshihiro T, Ariyama H, Yamaguchi K, Imajima T, Yamaga S, Tsuchihashi K, Isobe T, Kusaba H, Akashi K, Baba E.  Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer  Cancer Sci  2022  113(12):4207-4218  PubMed ID: 36053154   DOI: 10.1111/cas.15558
20610  Sasaki N, Shinji S, Shichi Y, Ishiwata T, Arai T, Yamada T, Takahashi G, Ohta R, Sonoda H, Matsuda A, Iwai T, Takeda K, Yonaga K, Ueda K, Kuriyama S, Miyasaka T, Yoshida H.  TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition.  Biochem Biophys Rep  2022  30:101239  PubMed ID: 35252596   DOI: 10.1016/j.bbrep.2022.101239
18212  Hiraide S, Takahashi M, Yoshida Y, Yamada H, Komine K, Ishioka C.  Tumor suppressor miR-193a-3p enhances efficacy of BRAF/MEK inhibitors in BRAF-mutated colorectal cancer  Cancer Sci  2021  112(9):3856-3870  PubMed ID: 34288281   DOI: 10.1111/cas.15075
15080  Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K.  Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells  Lab Invest  2021  101(8):1036-1047  PubMed ID: 33911189   DOI: 10.1038/s41374-021-00590-w
6918  Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.  Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.  Cell Chem Biol  2020  27(2):186-196  PubMed ID: 31813846   DOI: 10.1016/j.chembiol.2019.11.010
13234  Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.  Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32977947   DOI: 10.1016/j.bbrc.2020.09.007
13502  Nambara S, Masuda T, Kobayashi Y, Sato K, Tobo T, Koike K, Noda M, Ogawa Y, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Mimori K.  GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer  Cancer Sci  2020  111(2):343-355  PubMed ID: 31758608   DOI: 10.1111/cas.14248
11625  Kurosawa N, Wakata Y, Ida K, Midorikawa A, Isobe M.  High throughput development of TCR-mimic antibody that targets survivin-2B80-88/HLA-A*A24 and its application in a bispecific T-cell engager.  Sci Rep  2019    PubMed ID: 31285464   DOI: 10.1038/s41598-019-46198-5
11281  Suehiro Y, Takemoto Y, Nishimoto A, Ueno K, Shirasawa B, Tanaka T, Kugimiya N, Suga A, Harada E, Hamano K.  Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer.  Anticancer Res.  2018    PubMed ID: 30396941   DOI: 10.21873/anticanres.12977
4178  Ichimanda M, Hijiya N, Tsukamoto Y, Uchida T, Nakada C, Akagi T, Etoh T, Iha H, Inomata M, Takekawa M, Moriyama M.  Downregulation of dual-specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas.  Cancer Sci.  2018    PubMed ID: 29150975   DOI: 10.1111/cas.13444
10185  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773   DOI: 10.1038/bjc.2017.65
12615  Tokunaga R, Sakamoto Y, Nakagawa S, Miyake K, Izumi D, Kosumi K, Taki K, Higashi T, Imamura Y, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.  The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer  Ann Surg Oncol  2016  23(2):678-85  PubMed ID: 26416711   DOI: 10.1245/s10434-015-4879-3
14105  Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M.  SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer  Cancer Sci  2016  107(5):619-28  PubMed ID: 26892864   DOI: 10.1111/cas.12909
15077  Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt-Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R.  Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer  Gut  2016  65(8):1296-305  PubMed ID: 26001389   DOI: 10.1136/gutjnl-2014-309026
10157  Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano  The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells  J Cell Mol Med  2015  19(7):1569-81  PubMed ID: 25689483   DOI: 10.1111/jcmm.12531
10158  Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida  Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer  Mol Clin Oncol  2015  3(5):1080-1084  PubMed ID: 26623054   DOI: 10.3892/mco.2015.577
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
15897  Nishimoto A, Kugimiya N, Hosoyama T, Enoki T, Li TS, Hamano K.  HIF-1α activation under glucose deprivation plays a central role in the acquisition of anti-apoptosis in human colon cancer cells  Int J Oncol  2014  44(6):2077-84  PubMed ID: 24718784   DOI: 10.3892/ijo.2014.2367
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
7596  Suzuki S, Yamayoshi Y, Nishimuta A, Tanigawara Y.  S100A10 protein expression is associated with oxaliplatin sensitivity in human colorectal cancer cells.  Proteome Sci  2011  9:76  PubMed ID: 22206547   DOI: 10.1186/1477-5956-9-76
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
8700  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399   DOI: 10.1271/bbb.80324
8715  Kobori M, Ohnishi-Kameyama M, Akimoto Y, Yukizaki C, Yoshida M.  Alpha-eleostearic acid and its dihydroxy derivative are major apoptosis-inducing components of bitter gourd.  J. Agric. Food Chem.  2008  56:10515-20  PubMed ID: 18959405   DOI: 10.1021/jf8020877
8757  Lee JS, Ma CM, Park DK, Yoshimi Y, Hatanaka M, Hattori M.  Transformation of ergosterol peroxide to cytotoxic substances by rat intestinal bacteria.  Biol. Pharm. Bull.  2008  31:949-54  PubMed ID: 18451525   DOI: 10.1248/bpb.31.949
15636  Sasaki H, Miura K, Horii A, Kaneko N, Fujibuchi W, Kiseleva L, Gu Z, Murata Y, Karasawa H, Mizoi T, Kobayashi T, Kinouchi M, Ohnuma S, Yazaki N, Unno M, Sasaki I.  Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer  Cancer Sci  2008  99(4):711-9  PubMed ID: 18307535   DOI: 10.1111/j.1349-7006.2008.00725.x
15084  Maeda O, Kondo M, Fujita T, Usami N, Fukui T, Shimokata K, Ando T, Goto H, Sekido Y.  Enhancement of GLI1-transcriptional activity by beta-catenin in human cancer cells  Oncol Rep  2006  16(1):91-6  PubMed ID: 16786128  
3214  Hayashida, Yasuharu, Honda, Kazufumi, Idogawa, Masashi, Ino, Yoshinori, Ono, Masaya, Tsuchida, Akihiko, Aoki, Tatsuya, Hirohashi, Setsuo, Yamada, Tesshi  E-cadherin regulates the association between beta-catenin and actinin-4.  Cancer Res  2005  65:8836-45  PubMed ID: 16204054   DOI: 10.1158/0008-5472.CAN-05-0718
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251   DOI: 10.1002/pmic.200300795


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