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Cell No. : Cell Name
RCB1189 : THP-1  update : 2024/07/18
CommentHuman cell line derived from acute monocytic leukemia. Differentiate to macrophage-like cells by treatment of phorbol ester. The characteristics are somewhat different from THP-1 distributed from ATCC such as in cell size and drug sensitivities. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 16 prior to order.Application consideration
Comment from the depositor
Terms and conditions1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 16 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor DSMZ
Year of deposit 1995
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 1 year
Tissue peripheral blood
Disease name acute monocytic leukemia
Classification cancer
History overseas, DSMZ (ACC16)
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_0006
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 8-10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Virus (HIV) Lot.1 : LT 400
Virus (HTLV-1) Lot.1 : (-)
Chromosome mode Lot.1 : 83-94(50) : /88(7), 89(3), 90(6), 91(8), 92(11)/
STR(human) OK
deposit info
lot info
Reference information Reference 4
User's Publication 174

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4951  Tsuchiya S, Minegishi N, Minegishi M, Sato T, Konno T.  Adaptation of a human monocytic leukemia cell line (THP-1) in a protein-free chemically defined medium.  Tohoku J Exp Med  1986  150(4):455-65  PubMed ID: 3551191   DOI: 10.1620/tjem.150.455
4950  Tajima S, Hayashi R, Tsuchiya S, Miyake Y, Yamamoto A.  Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase.  Biochem Biophys Res Commun  1985  126(1):526-31  PubMed ID: 3855620   DOI: 10.1016/0006-291x(85)90637-0
4949  Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, Tada K.  Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.  Cancer Res  1982  42(4):1530-6  PubMed ID: 6949641  
720  Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K.  Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).  Int J Cancer  1980  26(2):171-6  PubMed ID: 6970727   DOI: 10.1002/ijc.2910260208

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User's Publication
19827  Yoshioka D, Nakamura T, Kubota Y, Takekawa M.  Formation of the NLRP3 inflammasome inhibits stress granule assembly by multiple mechanisms  J Biochem  2024  Jan 31:mvae009  PubMed ID: 38299728   DOI: 10.1093/jb/mvae009
21574  Kawakami K, Fukuda T, Toyoda M, Nakao Y, Hayashi C, Watanabe Y, Aoki T, Shinjo T, Iwashita M, Yamashita A, Shida M, Sanui T, Uchiumi T, Nishimura F.  Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation.  Biomed Res Int  2024  2024:8864513  PubMed ID: 38304347   DOI: 10.1155/2024/8864513
21592  Ito F, Yanatori I, Kato K, Toyokuni S.  Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models.  STAR Protoc  2024  5(1):102892  PubMed ID: 38363686   DOI: 10.1016/j.xpro.2024.102892
21650  Matsuo H, Inagami A, Ito Y, Ito N, Iyoda S, Harata Y, Higashitani M, Shoji K, Tanaka M, Noura M, Mikami T, Kato I, Takita J, Nakahata T, Adachi S.  Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes.  Commun Biol  2024  7(1):123  PubMed ID: 38267545   DOI: 10.1038/s42003-024-05811-8
21651  Tatsuno R, Ichikawa J, Komohara Y, Pan C, Kawasaki T, Enomoto A, Aoki K, Hayakawa K, Iwata S, Jubashi T, Haro H.  Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway.  Cell Death Dis  2024  15(2):108  PubMed ID: 38302407   DOI: 10.1038/s41419-024-06487-y
17688  Washisaka T, Tabata Y.  Live Imaging of Monocyte/Macrophage Differentiation with Cationized Gelatin Nanospheres Incorporating a Molecular Beacon  ACS Biomater Sci Eng  2023  Apr 4  PubMed ID: 37014020   DOI: 10.1021/acsbiomaterials.2c01420
19580  Murokawa H, Egusa K, Shibutani S, Iwata H.  Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling is involved in phagocytosis activation during THP-1 cell differentiation  J Vet Med Sci  2023  85(7):772-780  PubMed ID: 37225457   DOI: 10.1292/jvms.22-0504
19871  Yamada M, Nitta Y, Uehara T, Suzuki H, Miya F, Takenouchi T, Tamura M, Ayabe S, Yoshiki A, Maeno A, Saga Y, Furuse T, Yamada I, Okamoto N, Kosaki K, Sugie A.  Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences  Eur J Med Genet  2023  66(8):104804  PubMed ID: 37369308   DOI: 10.1016/j.ejmg.2023.104804
21116  Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y.  Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.  Cells  2023  12(4)  PubMed ID: 36831269   DOI: 10.3390/cells12040602
21363  Unzai T, Washisaka T, Tabata Y.  An artificial silk elastin-like protein modifies the polarization of human macrophages line THP-1.  J Biomater Appl  2023  8853282231192186  PubMed ID: 37494553   DOI: 10.1177/08853282231192186
21394  Egusa K, Shibutani S, Iwata H.  IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K).  Biochem Biophys Res Commun  2023  679:160-166  PubMed ID: 37696069   DOI: 10.1016/j.bbrc.2023.09.008
21518  Hirata W, Itatani Y, Masui H, Kawada K, Mizuno R, Yamamoto T, Okamoto T, Ogawa R, Inamoto S, Maekawa H, Okamura R, Kiyasu Y, Hanada K, Okamoto M, Nishikawa Y, Sugimoto N, Tamura T, Hatano E, Sakai Y, Obama K.  Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage.  Sci Rep  2023  13(1):22217  PubMed ID: 38097649   DOI: 10.1038/s41598-023-49312-w
17691  Ushio S, Wada Y, Nakamura M, Matsumoto D, Hoshika K, Shiromizu S, Iwata N, Esumi S, Kajizono M, Kitamura Y, Sendo T.  Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition  Front Pharmacol  2022  13:890048  PubMed ID: 36034871   DOI: 10.3389/fphar.2022.890048
20632  Kasai F, Hirayama N, Fukushima M, Kohara A, Nakamura Y.  THP-1 reference data: proposal of an in vitro branched evolution model for cancer cell lines.  Int J Cancer  2022    PubMed ID: 35373342   DOI: 10.1002/ijc.34019
16920  Ikegami H, Yamasaki K, Ogawa M, Nemoto K, Akata K, Noguchi S, Fukuda K, Kawanami T, Mukae H, Yatera K.  Reduced phagocytic activity of human alveolar macrophages infected with Mycobacterium avium complex  J Infect Chemother  2022  Aug 1  PubMed ID: 35926765   DOI: 10.1016/j.jiac.2022.07.018
16971  Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M.  Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells  Int J Mol Sci  2022  23(15):8660  PubMed ID: 35955793   DOI: 10.3390/ijms23158660
20842  Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.  Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.  J Oral Microbiol  2022  14(1):2105013  PubMed ID: 35937899   DOI: 10.1080/20002297.2022.2105013
20897  Ito M, Maejima Y, Nishimura K, Nakae Y, Ono A, Iwaki-Egawa S.  A role for N-glycosylation in active adenosine deaminase 2 production.  Biochim Biophys Acta Gen Subj  2022  1866(12):130237  PubMed ID: 36029899   DOI: 10.1016/j.bbagen.2022.130237
20957  Yokohata S, Ohkura K, Nagamune H, Tomoyasu T, Tabata A.  Human serum albumin stabilizes streptolysin S activity secreted in the extracellular milieu by streptolysin S-producing streptococci.  Microbiol Immunol  2022    PubMed ID: 36478453   DOI: 10.1111/1348-0421.13042
13032  Kanai R, Nakashima A, Doi S, Kimura T, Yoshida K, Maeda S, Ishiuchi N, Yamada Y, Ike T, Doi T, Kato Y, Masaki T.  Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis.  Sci Rep  2021    PubMed ID: 33441701   DOI: 10.1038/s41598-020-79664-6
13296  Nakatani K, Matsuo H, Harata Y, Higashitani M, Koyama A, Noura M, Nishinaka-Arai Y, Kamikubo Y, Adachi S.  Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.  Int J Hematol  2021  113(2):243-253  PubMed ID: 33068248   DOI: 10.1007/s12185-020-03015-4
13347  Fujita M, Yamamoto H, Yoshida N, Ono R, Matsuoka T, Kihara S.  Atheroprotective Roles of Adiponectin via CCL2 Inhibition.  J Atheroscler Thromb  2021  28(11):1204-1213  PubMed ID: 33191365   DOI: 10.5551/jat.58875
13382  Li H, Somiya M, Kuroda S.  Enhancing antibody-dependent cellular phagocytosis by Re-education of tumor-associated macrophages with resiquimod-encapsulated liposomes.  Biomaterials  2021    PubMed ID: 33338932   DOI: 10.1016/j.biomaterials.2020.120601
13541  Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, Iwasaki H.  Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway  Transl Res  2021  227:53-63  PubMed ID: 32687976   DOI: 10.1016/j.trsl.2020.07.005
20199  Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S.  Extracellular mRNA transported to the nucleus exerts translation-independent function.  Nat Commun  2021  12(1):3655  PubMed ID: 34135341   DOI: 10.1038/s41467-021-23969-1
20239  Kawakatsu K, Maemura M, Seta Y, Nishikata T.  Involvement of Annexin A2 in Serum-MAF Dependent Phagocytic Activation of Macrophages.  Anticancer Res  2021  41(8):4089-4092  PubMed ID: 34281879   DOI: 10.21873/anticanres.15211
15109  Minoru Sasaki, Yu Shimoyama, Yoshitoyo Kodama, Taichi Ishikawa  Abiotrophia defectiva DnaK Promotes Fibronectin-Mediated Adherence to HUVECs and Induces a Proinflammatory Response  International Journal of Molecular Sciences  2021  22(8528)  PubMed ID: 34445234   DOI: 10.3390/ijms22168528
15492  Lee S, Ishitsuka A, Kuroki T, Lin YH, Shibuya A, Hongu T, Funakoshi Y, Kanaho Y, Nagata K, Kawaguchi A.  Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes  JCI Insight  2021  6(16):e139190  PubMed ID: 34423792   DOI: 10.1172/jci.insight.139190
20374  Kato S, Arasaki K, Tokutomi N, Imai Y, Inoshita T, Hattori N, Sasaki T, Sato M, Wakana Y, Inoue H, Tagaya M.  Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms.  J Cell Sci  2021    PubMed ID: 34704591   DOI: 10.1242/jcs.258699
20487  Sakamaki I, Fukushi M, Ohashi W, Tanaka Y, Itoh K, Tomihara K, Yamamoto Y, Iwasaki H.  Sitafloxacin reduces tumor necrosis factor alpha (TNFα) converting enzyme (TACE) phosphorylation and activity to inhibit TNFα release from lipopolysaccharide-stimulated THP-1 cells.  Sci Rep  2021  11(1):24154  PubMed ID: 34921186   DOI: 10.1038/s41598-021-03511-5
20490  Ito F, Kato K, Yanatori I, Murohara T, Toyokuni S.  Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.  Redox Biol  2021  47:102174  PubMed ID: 34700146   DOI: 10.1016/j.redox.2021.102174
20561  Sasaki M, Shimoyama Y, Kodama Y, Ishikawa T.  Tryptophanyl tRNA Synthetase from Human Macrophages Infected by Porphyromonas gingivalis Induces a Proinflammatory Response Associated with Atherosclerosis.  Pathogens  2021  10(12)  PubMed ID: 34959604   DOI: 10.3390/pathogens10121648
10948  Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura  Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages  Front Immunol  2020  11:709  PubMed ID: 32373130   DOI: 10.3389/fimmu.2020.00709
10952  Seiichi Sato, Kai Li, Nozomi Sakurai, Mei Hashizume, Sunanda Baidya, Hirotaka Nonaka, Koki Noguchi, Kozo Ishikawa, Chikashi Obuse, Akinori Takaoka  Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections  Cell Immunol  2020  356:104188  PubMed ID: 32763501   DOI: 10.1016/j.cellimm.2020.104188
12599  Kobayashi N, Oda T, Takizawa M, Ishizaki T, Tsukamoto N, Yokohama A, Takei H, Saitoh T, Shimizu H, Honma K, Kimura-Masuda K, Kuroda Y, Ishihara R, Murakami Y, Murakami H, Handa H.  Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma  Cancers (Basel)  2020  12(2):363  PubMed ID: 32033262   DOI: 10.3390/cancers12020363
13083  Matsushita M, Nakamura T, Moriizumi H, Miki H, Takekawa M.  Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.  Sci Adv  2020    PubMed ID: 32637591   DOI: 10.1126/sciadv.aay9778
13133  Tabata A, Ohkuni H, Hino H, Saigo T, Kodama C, Tang Q, Tomoyasu T, Fukunaga Y, Itoh Y, Nagamune H.  Cytotoxic property of Streptococcus mitis strain producing two different types of cholesterol-dependent cytolysins.  Infect Genet Evol  2020    PubMed ID: 32731044   DOI: 10.1016/j.meegid.2020.104483
13143  Akamatsu M, Mashiba R, Kawakatsu K, Ishikawa M, Nishikata T.  Comparison of Macrophage Activation Using γ-Globulin and Serum-derived Macrophage Activating Factor.  Anticancer Res  2020    PubMed ID: 32727796   DOI: 10.21873/anticanres.14471
13307  Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y.  CELF2 regulates the species-specific alternative splicing of TREM2.  Sci Rep  2020    PubMed ID: 33093587   DOI: 10.1038/s41598-020-75057-x
13354  Noura M, Morita K, Kiyose H, Matsuo H, Nishinaka-Arai Y, Kurokawa M, Kamikubo Y, Adachi S.  Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells.  Sci Rep  2020    PubMed ID: 33219287   DOI: 10.1038/s41598-020-76951-0
13456  Hideo Kataoka, Ayumi Saeki, Akira Hasebe, Ken-ichiro Shibata, Takeshi Into  Naringenin suppresses Toll-like receptor 2-mediated inflammatory responses through inhibition of receptor clustering on lipid rafts  Food Sci Nutr  2020    PubMed ID: 33598179   DOI: 10.1002/fsn3.2063
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549   DOI: 10.1038/s41467-019-09028-w
11472  Suzuki S, Fukuda T, Nagayasu S, Nakanishi J, Yoshida K, Hirata-Tsuchiya S, Nakao Y, Sano T, Yamashita A, Yamada S, Ohta K, Shiba H, Nishimura F.  Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles.  Sci Rep  2019    PubMed ID: 30846715   DOI: 10.1038/s41598-019-40046-2
6911  Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H.  β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.  J Oral Microbiol  2019  11(1):1609839.   PubMed ID: 31105901   DOI: 10.1080/20002297.2019.1609839
6929  Minato KI, Laan LC, van Die I, Mizuno M.  Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation.  Int J Biol Macromol  2019  122:705-712  PubMed ID: 30392853   DOI: 10.1016/j.ijbiomac.2018.10.157
6943  Yamamoto M, Matsumura R, Hirata Y, Nagamune H.  A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods.  Toxicol In Vitro  2019  54:75-81  PubMed ID: 30240708   DOI: 10.1016/j.tiv.2018.09.009
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478   DOI: 10.1038/s41598-019-44817-9
12329  Iwashima T, Kudome Y, Kishimoto Y, Saita E, Tanaka M, Taguchi C, Hirakawa S, Mitani N, Kondo K, Iida K.  Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3  Food Nutr Res  2019  16;63  PubMed ID: 31452653   DOI: 10.29219/fnr.v63.3361
12559  Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai TC, Nishiuchi T, Tanaka T, Barbie DA, Mukaida N, Takahashi C.  Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion  Cancer Res  2019  79(15):3903-3915  PubMed ID: 31189648   DOI: 10.1158/0008-5472.CAN-18-3604
12597  Horiguchi Y, Ohta N, Yamamoto S, Koide M, Fujino Y.  Midazolam suppresses the lipopolysaccharide-stimulated immune responses of human macrophages via translocator protein signaling  Int Immunopharmacol  2019  66:373-382.  PubMed ID: 30530051   DOI: 10.1016/j.intimp.2018.11.050
12600  Giriwono PE, Shirakawa H, Ohsaki Y, Sato S, Aoyama Y, Ho HJ, Goto T, Komai M.  Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells  Int J Mol Sci  2019  20(9):2320  PubMed ID: 31083375   DOI: 10.3390/ijms20092320
10592  Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040   DOI: 10.1016/j.biomaterials.2017.10.045
11096  Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y, Sonoda Y.  A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.  Nat Commun  2018  9(1):2202  PubMed ID: 29875383   DOI: 10.1038/s41467-018-04441-z
11176  Watanabe K, Suzuki H, Nishida T, Mishima M, Tachibana M, Fujishima M, Shimizu T, Watarai M.  Identification of novel Legionella genes required for endosymbiosis in Paramecium based on comparative genome analysis with Holospora spp.  FEMS Microbiol. Ecol.  2018  94(11)  PubMed ID: 30124811   DOI: 10.1093/femsec/fiy162
11247  Zhitnyuk Y, Gee P, Lung MSY, Sasakawa N, Xu H, Saito H, Hotta A.  Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30316514   DOI: 10.1016/j.bbrc.2018.09.113
11288  Segawa S, Kondo Y, Nakai Y, Iizuka A, Kaneko S, Yokosawa M, Furuyama K, Tsuboi H, Goto D, Matsumoto I, Sumida T.  Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease.  J. Immunol.  2018    PubMed ID: 30404814   DOI: 10.4049/jimmunol.1800667
4362  Nagai K, Domon H, Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y.  Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.  Cell. Immunol.  2018  325:14-22  PubMed ID: 29366563   DOI: 10.1016/j.cellimm.2018.01.006
4363  Yoshino H, Konno H, Ogura K, Sato Y, Kashiwakura I.  Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages.  Int J Mol Sci  2018    PubMed ID: 30322167   DOI: 10.3390/ijms19103154
4364  Mashiba R, Ishikawa M, Sumiya YU, Kawakatsu K, Tran NK, Nishikata T.  Phagocytic Activation of Macrophages with Serum MAF Depends on Engulfment Efficiency and Not Migratory Activity.  Anticancer Res.  2018  38(7):4295-4298  PubMed ID: 29970564   DOI: 10.21873/anticanres.12727
4365  Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.  NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.  Mol Med Rep  2018  18(6):5279-5285  PubMed ID: 30320338   DOI: 10.3892/mmr.2018.9533
4366  Komoda H, Shiraki A, Oyama JI, Nishikido T, Node K.  Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel.  J. Atheroscler. Thromb.  2018  25(8):690-69  PubMed ID: 29398679   DOI: 10.5551/jat.41798
4506  Ebe H, Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T.  Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis.  Clin. Exp. Immunol.  2018  191(3):338-348  PubMed ID: 29080328   DOI: 10.1111/cei.13076
4507  Yoshida K, Nakashima A, Doi S, Ueno T, Okubo T, Kawano KI, Kanawa M, Kato Y, Higashi Y, Masaki T.  Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis.  Stem Cells Transl Med  2018  7(12):893-905  PubMed ID: 30269426   DOI: 10.1002/sctm.17-0284
10181  Yoshino H, Kumai Y, Kashiwakura I.  Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages.  Mol Med Rep  2017  15:2867-2872  PubMed ID: 28447729   DOI: 10.3892/mmr.2017.6298
4520  Ken-ichiro Minato, Akihiro Ohara, and Masashi Mizuno  A Proinflammatory Effect of the β-Glucan from Pleurotus cornucopiae Mushroom on Macrophage Action  Mediators of Inflammation  2017  9  PubMed ID: 28611507   DOI: 10.1155/2017/8402405
4546  Arasaki K, Mikami Y, Shames SR, Inoue H, Wakana Y, Tagaya M.  Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.  Nat Commun  2017  8:15406  PubMed ID: 28504273   DOI: 10.1038/ncomms15406
10964  Masataka Oda, Hisanori Domon, Mie Kurosawa, Toshihito Isono, Tomoki Maekawa, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao   Streptococcus pyogenes Phospholipase A 2 Induces the Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells and Aorta of Mice  Front Cell Infect Microbiol  2017  7:300  PubMed ID: 28713783   DOI: 10.3389/fcimb.2017.00300
14596  Yoshino H, Kashiwakura I.  Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expression in human monocytic cells  J Radiat Res  2017  58(5):626-635  PubMed ID: 28369600   DOI: 10.1093/jrr/rrx011
14666  Tabei Y, Sugino S, Eguchi K, Tajika M, Abe H, Nakajima Y, Horie M.  Effect of calcium carbonate particle shape on phagocytosis and pro-inflammatory response in differentiated THP-1 macrophages  Biochem Biophys Res Commun  2017  490(2):499-505  PubMed ID: 28624457   DOI: 10.1016/j.bbrc.2017.06.069
14711  Hojo K, Tamai R, Kobayashi-Sakamoto M, Kiyoura Y.  Etidronate down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB activation  Pharmacol Rep  2017  69(4):773-778  PubMed ID: 28587938   DOI: 10.1016/j.pharep.2017.03.009
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