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Cell No. : Cell Name
RCB1189 : THP-1  update : 2020/01/23
CommentDifferentates to macrophage-like cells after treatment with phorbol ester. The variant subline (RCB2128 A-THP-1). Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 16 prior to order.Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 16 prior to order. In addition, regarding commercial use and use for patent filing the users of this cell line must contact RIKEN BRC prior to order.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor DSMZ
Year of deposit 1995
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 1 year
Tissue peripheral blood
Case history acute monocytic leukemia
Classification cancer
History overseas, DSMZ (ACC16)
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) LT 400
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 83-94(50) : /88(7), 89(3), 90(6), 91(8), 92(11)/
Images
deposit info
lot info
Reference information Reference 4
User's Publication 84


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Reference
4951  Tsuchiya S, Minegishi N, Minegishi M, Sato T, Konno T.  Adaptation of a human monocytic leukemia cell line (THP-1) in a protein-free chemically defined medium.  Tohoku J Exp Med  1986  150(4):455-65  PubMed ID: 3551191
4950  Tajima S, Hayashi R, Tsuchiya S, Miyake Y, Yamamoto A.  Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase.  Biochem Biophys Res Commun  1985  126(1):526-31  PubMed ID: 3855620
4949  Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, Tada K.  Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.  Cancer Res  1982  42(4):1530-6  PubMed ID: 6949641
720  Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K.  Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).  Int J Cancer  1980  26(2):171-6  PubMed ID: 6970727

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User's Publication
10948  Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura  Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages  Front Immunol  2020  11:709  PubMed ID: 32373130
10952  Seiichi Sato, Kai Li, Nozomi Sakurai, Mei Hashizume, Sunanda Baidya, Hirotaka Nonaka, Koki Noguchi, Kozo Ishikawa, Chikashi Obuse, Akinori Takaoka  Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections  Cell Immunol  2020  356:104188  PubMed ID: 32763501
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549
6911  Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H.  β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.  J Oral Microbiol  2019  11(1):1609839.   PubMed ID: 31105901
6929  Minato KI, Laan LC, van Die I, Mizuno M.  Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation.  Int J Biol Macromol  2019  122:705-712  PubMed ID: 30392853
6943  Yamamoto M, Matsumura R, Hirata Y, Nagamune H.  A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods.  Toxicol In Vitro  2019  54:75-81  PubMed ID: 30240708
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478
12329  Iwashima T, Kudome Y, Kishimoto Y, Saita E, Tanaka M, Taguchi C, Hirakawa S, Mitani N, Kondo K, Iida K.  Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3  Food Nutr Res  2019  16;63  PubMed ID: 31452653
10592  Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040
11096  Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y, Sonoda Y.  A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.  Nat Commun  2018  9(1):2202  PubMed ID: 29875383
11176  Watanabe K, Suzuki H, Nishida T, Mishima M, Tachibana M, Fujishima M, Shimizu T, Watarai M.  Identification of novel Legionella genes required for endosymbiosis in Paramecium based on comparative genome analysis with Holospora spp.  FEMS Microbiol. Ecol.  2018  94(11)  PubMed ID: 30124811
11247  Zhitnyuk Y, Gee P, Lung MSY, Sasakawa N, Xu H, Saito H, Hotta A.  Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30316514
11288  Segawa S, Kondo Y, Nakai Y, Iizuka A, Kaneko S, Yokosawa M, Furuyama K, Tsuboi H, Goto D, Matsumoto I, Sumida T.  Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease.  J. Immunol.  2018    PubMed ID: 30404814
4362  Nagai K, Domon H, Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y.  Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.  Cell. Immunol.  2018  325:14-22  PubMed ID: 29366563
4363  Yoshino H, Konno H, Ogura K, Sato Y, Kashiwakura I.  Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages.  Int J Mol Sci  2018    PubMed ID: 30322167
4364  Mashiba R, Ishikawa M, Sumiya YU, Kawakatsu K, Tran NK, Nishikata T.  Phagocytic Activation of Macrophages with Serum MAF Depends on Engulfment Efficiency and Not Migratory Activity.  Anticancer Res.  2018  38(7):4295-4298  PubMed ID: 29970564
4365  Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.  NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.  Mol Med Rep  2018  18(6):5279-5285  PubMed ID: 30320338
4366  Komoda H, Shiraki A, Oyama JI, Nishikido T, Node K.  Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel.  J. Atheroscler. Thromb.  2018  25(8):690-69  PubMed ID: 29398679
4506  Ebe H, Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T.  Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis.  Clin. Exp. Immunol.  2018  191(3):338-348  PubMed ID: 29080328
4507  Yoshida K, Nakashima A, Doi S, Ueno T, Okubo T, Kawano KI, Kanawa M, Kato Y, Higashi Y, Masaki T.  Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis.  Stem Cells Transl Med  2018  7(12):893-905  PubMed ID: 30269426
10181  Yoshino H, Kumai Y, Kashiwakura I.  Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages.  Mol Med Rep  2017  15:2867-2872  PubMed ID: 28447729
4520  Ken-ichiro Minato, Akihiro Ohara, and Masashi Mizuno  A Proinflammatory Effect of the β-Glucan from Pleurotus cornucopiae Mushroom on Macrophage Action  Mediators of Inflammation  2017  9  PubMed ID: 28611507
10964  Masataka Oda, Hisanori Domon, Mie Kurosawa, Toshihito Isono, Tomoki Maekawa, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao   Streptococcus pyogenes Phospholipase A 2 Induces the Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells and Aorta of Mice  Front Cell Infect Microbiol  2017  7:300  PubMed ID: 28713783
9865  Seike S, Takehara M, Kobayashi K, Nagahama M.  Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death.  Biochim. Biophys. Acta  2016  1858:3150-3156  PubMed ID: 27720686
9972  Uchida H, Hasegawa Y, Takahashi H, Makishima M.  1α-Dihydroxyvitamin D3 and Retinoic Acid Increase Nuclear Vitamin D Receptor Expression in Monocytic THP-1 Cells.  Anticancer Res.  2016  36:6297-6301  PubMed ID: 27919949
7231  Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.  The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.  Nat. Immunol.  2015  16:1034-43  PubMed ID: 26322480
7239  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J.  Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.  Biochim. Biophys. Acta  2015  1850:2159-67  PubMed ID: 26299247
7251  Yanagisawa K, Ogawa Y, Uchiumi H, Gohda F, Mawatari M, Ishizaki T, Mitsui T, Yokohama A, Handa H, Tsukamoto N, Nojima Y.  Gene polymorphisms of mannose-binding lectin confer susceptibility to Pneumocystis pneumonia in HIV-infected patients.  J. Infect. Chemother.  2015  21:769-75  PubMed ID: 26271591
7288  Inoue T, Ishikawa M, Sumiya Y, Kohda H, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T.  Establishment of a Macrophage-activating Factor Assay System Using the Human Monocytic Cell Line THP-1.  Anticancer Res.  2015  35:4441-5  PubMed ID: 26168484
7316  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.  Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.  Nat Commun  2015  6:7360  PubMed ID: 26059659
7533  Jian Sun, Hiroko Shigemi, Yukie Tanaka, Takahiro Yamauchi, Takanori Ueda, Hiromichi Iwasaki  Tetracyclines downregulate the production of LPS-induced cytokines and chemokines in THP-1 cells via ERK, p38, and nuclear factor-κB signaling pathways.  Biochemistry and Biophysics Reports  2015  4:397-404 
7556  S Yoshimatsu, T Kato-Matsumaru, A Aono, K Chikamatsu, H Yamada, S Mitarai  Factors contribute to efficiency of specimen concentration of Mycobacterium tuberculosis by centrifugation and magnetic beads.  International Journal of Mycobacteriology  2015  4:245-249 
10969  Takuya Shimizu, Yusuke Masuo, Saki Takahashi, Noritaka Nakamichi, Yukio Kato  Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice  Drug Metab Pharmacokinet  2015  30(3):231-9  PubMed ID: 26003890
6468  Takahashi H, Hatta Y, Iriyama N, Hasegawa Y, Uchida H, Nakagawa M, Makishima M, Takeuchi J, Takei M.  Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3.  PLoS One  2014  9(11):e113722  PubMed ID: 25409436
6091  Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T.  Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages.  Microbes Infect  2012  14(11):916-21  PubMed ID: 22561467
10968  Hiroharu Kobayashi, Yoriko Yamashita, Akira Iwase, Yutaka Yoshikawa, Hiroyuki Yasui, Yoshichika Kawai, Koji Uchida, Nozomi Uno, Shinya Akatsuka, Takashi Takahashi, Fumitaka Kikkawa, Shinya Toyokuni  The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis  Fertil Steril  2012  98(2):415-22.e1-12  PubMed ID: 22633261
7638  Satoh J, Shimamura Y, Tabunoki H.  Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease.  Cell. Mol. Neurobiol.  2011  32:337-43  PubMed ID: 22080356
7695  Kanai Y, Hiroki S, Koshino H, Konoki K, Cho Y, Cayme M, Fukuyo Y, Yotsu-Yamashita M.  Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue.  J. Lipid Res.  2011  52:2245-54  PubMed ID: 21893678
7701  Oya K, Sakamoto N, Ohashi T, Sato M.  Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages.  Biochem. Biophys. Res. Commun.  2011  412:678-82  PubMed ID: 21867689
7704  Ozasa H, Ayaori M, Iizuka M, Terao Y, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Uehara Y, Ogura M, Sasaki M, Komatsu T, Horii S, Mochizuki S, Yoshimura M, Ikewaki K.  Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARγ/LXRα pathway: findings from in vitro and ex vivo studies.  Atherosclerosis  2011  219:141-50  PubMed ID: 21862012
7813  Taira M, Shimoyama Y, Kagiya T, Sasaki M, Nezu T, Harada H, Kimura S.  Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions.  Dent Mater J  2011  30:293-9  PubMed ID: 21597227
5413  Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H.  Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines.  Int J Nanomedicine  2011  6:3487-97  PubMed ID: 22267932
9085  Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda  Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli  Gene  2011  478 (1-2), 1-10  PubMed ID: 21262333
8120  Mizuno K, Toyoda Y, Fukami T, Nakajima M, Yokoi T.  Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway.  Arch. Toxicol.  2010  85:199-207  PubMed ID: 20848085
8130  Mizuno K, Fukami T, Toyoda Y, Nakajima M, Yokoi T.  Terbinafine stimulates the pro-inflammatory responses in human monocytic THP-1 cells through an ERK signaling pathway.  Life Sci.  2010  87:537-44  PubMed ID: 20816994
8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766
8393  Uto-Kondo H, Ayaori M, Ogura M, Nakaya K, Ito M, Suzuki A, Takiguchi S, Yakushiji E, Terao Y, Ozasa H, Hisada T, Sasaki M, Ohsuzu F, Ikewaki K.  Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages.  Circ. Res.  2010  106:779-87  PubMed ID: 20075335
8402  Iizuka M, Tani M, Kishimoto Y, Saita E, Toyozaki M, Kondo K.  Inhibitory effects of balsamic vinegar on LDL oxidation and lipid accumulation in THP-1 macrophages.  J. Nutr. Sci. Vitaminol.  2010  56:421-7  PubMed ID: 21422711
9080  Akihiro Unno, Katsuya Kitoh, Yasuhiro Takashima  Up-regulation of Hyaluronan Receptors in Toxoplasma Gondii-Infected Monocytic Cells  Biochem Biophys Res Commun  2010  391 (1), 477-80  PubMed ID: 19914206
8413  Lu X, Ohata K, Kondo Y, Espinoza JL, Qi Z, Nakao S.  Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis.  Cancer Sci.  2009  101:609-15  PubMed ID: 20028385
8456  Fujimoto A, Akifusa S, Kamio N, Hirofuji T, Nonaka K, Yamashita Y.  Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species.  Free Radic. Res.  2009  44:128-34  PubMed ID: 19886750
8526  Taira M, Kagiya T, Harada H, Sasaki M, Kimura S, Narushima T, Nezu T, Araki Y.  Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles.  J Mater Sci Mater Med  2009  21:267-75  PubMed ID: 19644653
8535  Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Higuchi K, Takeuchi K, Arakawa T.  Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.  Am. J. Physiol. Gastrointest. Liver Physiol.  2009  297:G506-13  PubMed ID: 19589943
8547  Hojo-Nakashima I, Sato R, Nakashima K, Hagiwara T, Yamada M.  Dynamic expression of peptidylarginine deiminase 2 in human monocytic leukaemia THP-1 cells during macrophage differentiation.  J. Biochem.  2009  146:471-9  PubMed ID: 19564157
8564  Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, Furusawa K, Kurihara S, Wang PL.  Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease.  J. Periodont. Res.  2009  44:21-7  PubMed ID: 19515019
8579  Amano Y, Cho Y, Matsunawa M, Komiyama K, Makishima M.  Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.  J. Steroid Biochem. Mol. Biol.  2009  114:144-51  PubMed ID: 19429444
8604  Matsuki K, Tamasawa N, Yamashita M, Tanabe J, Murakami H, Matsui J, Imaizumi T, Satoh K, Suda T.  Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.  Atherosclerosis  2009  206:434-8  PubMed ID: 19376519
8616  Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M.  Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.  Biol. Pharm. Bull.  2009  32:564-72  PubMed ID: 19336885
6132  Naito H, Kidoya H, Sato Y, Takakura N.  Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.  J Biochem  2009  145(5):653-9  PubMed ID: 19179360
6303  Taira M, Nezu T, Sasaki M, Kimura S, Kagiya T, Harada H, Narushima T, Araki Y.  Gene expression analyses of human macrophage phagocytizing sub-micro titanium particles by allergy DNA chip (Genopal).  Biomed Mater Eng  2009  19(1):63-70  PubMed ID: 19458447
8700  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399
5403  Hirasawa A, Itsubo C, Sadakane K, Hara T, Shinagawa S, Koga H, Nose H, Koshimizu TA, Tsujimoto G.  Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1).  Biochem Biophys Res Commun  2008  365:22-8  PubMed ID: 17980148
3586  Haga A, Funasaka T, Deyashiki Y, Raz A.  Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway.  FEBS Lett.  2008  582(13):1877-82  PubMed ID: 18485900
8818  Matsumoto E, Hatanaka M, Bohgaki M, Maeda S.  PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.  Kobe J Med Sci  2007  52:181-94  PubMed ID: 17329956
10072  Yoshinari Uehara 1, Shin-ichiro Miura, Arnold von Eckardstein, Satomi Abe, Akihiro Fujii, Yoshino Matsuo, Stephan Rust, Stefan Lorkowski, Gerd Assmann, Tatsuo Yamada, Keijiro Saku  Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element  Atherosclerosis  2007  191(1):11-21  PubMed ID: 16730733
8914  Hisakage Funabashi, Riko Matsuzawaa, Makiko Nakamura, Masayasu Mie and Eiry Kobatake  Bioluminescent enumeration of surface antigen-specific cells using the streptavidin?luciferase fusion protein  Sensors and Actuators B: Chemical  2006  120:51-56 
3538  Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, Miyazawa M, Ito Y, Suzuki H, Toyoda H.  Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.  Toxicol In Vitro  2006  20(5):767-73  PubMed ID: 16311011
3539  Sakaguchi H, Ashikaga T, Miyazawa M, Yoshida Y, Ito Y, Yoneyama K, Hirota M, Itagaki H, Toyoda H, Suzuki H.  Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.  Toxicol In Vitro  2006  20(5):774-84  PubMed ID: 16337770
3393  Isse, Kumiko, Harada, Kenichi, Zen, Yoh, Kamihira, Takashi, Shimoda, Shinji, Harada, Mine, Nakanuma, Yasuni  Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts.  Hepatology  2005  41:506-16  PubMed ID: 15726664
3270  Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.  Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.  Hepatol. Res.  2005  33:198-205  PubMed ID: 16198622
2862  Liu Y, Yang H, Otaka K, Takatsuki H, Sakanishi A.  Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration.  Colloids Surf B Biointerfaces  2005  43(3-4):216-20  PubMed ID: 15978788
2938  Harada H, Suzu S, Hayashi Y, Okada S.  BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule.  J Cell Physiol  2005  204(3):919-26  PubMed ID: 15795899
3076  Sumita C, Yamane M, Matsuda T, Maeda M, Nariai T, Fujio Y, Azuma J.  Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages.  FEBS Lett  2005  579(18):4038-42.  PubMed ID: 16004986
3349  Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, Yamanaka M, Eda S, Beppu M.  A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells.  J Biol Chem  2005  280(47):39284-93  PubMed ID: 16135517
11007  Tetsuji Tanaka , Tao Bai, Kazunori Yukawa, Naohiko Umesaki  Radiation-induced cell death is independent of the apoptotic signals mediated by death-associated protein kinase in human cervical squamous cell carcinoma cells  Oncol Rep  2005  14(4):949-55  PubMed ID: 16142356
3075  Sumita C, Maeda M, Fujio Y, Kim J, Fujitsu J, Kasayama S, Yamamoto I, Azuma J.  Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.  Biochim Biophys Acta  2004  1673(3):115-21  PubMed ID: 15279882
3195  Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K, Maeda K, Nagaretani H, Kishida K, Maeda N, Nagasawa A, Funahashi T, Matsuzawa Y.  Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.  Circulation  2004  109(17):2046-9  PubMed ID: 15096450
3074  Maeda M, Yamamoto I, Fujio Y, Azuma J.  Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages.  Biochim Biophys Acta  2003  1623(1):41-6  PubMed ID: 12957716
9032  N Kiyokawa, T Mori, T Taguchi, M Saito, K Mimori, T Suzuki, T Sekino, N Sato, H Nakajima, Y U Katagiri, T Takeda, J Fujimoto  Activation of the Caspase Cascade During Stx1-induced Apoptosis in Burkitt's Lymphoma Cells  J Cell Biochem  2001  81 (1), 128-42  PubMed ID: 11180403
10997  K Fukuda, S Akao, Y Ohno, K Yamashita, H Fujiwara  Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1  Cancer Lett   2001  164(1):7-13  PubMed ID: 11166910
11022  K Fukuda, Y Hibiya, M Mutoh, Y Ohno, K Yamashita, S Akao, H Fujiwara  Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1  Biochem Pharmacol  2000  60(4):595-600  PubMed ID: 10874135
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