CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1189 : THP-1]

4951 Tsuchiya S, Minegishi N, Minegishi M, Sato T, Konno T. Adaptation of a human monocytic leukemia cell line (THP-1) in a protein-free chemically defined medium. Tohoku J Exp Med 1986 150(4):455-65 PubMed ID: 3551191 DOI: 10.1620/tjem.150.455

4950 Tajima S, Hayashi R, Tsuchiya S, Miyake Y, Yamamoto A. Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase. Biochem Biophys Res Commun 1985 126(1):526-31 PubMed ID: 3855620 DOI: 10.1016/0006-291x(85)90637-0

4949 Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, Tada K. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res 1982 42(4):1530-6 PubMed ID: 6949641

720 Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). Int J Cancer 1980 26(2):171-6 PubMed ID: 6970727 DOI: 10.1002/ijc.2910260208

Top

User's Publication

22579 Kimura M, Ogawa Y, Motohashi S, Imamoto N. Changes in importin levels promote nuclear proteasomal degradation of cell cycle-related proteins during THP-1 monocyte-to-macrophage differentiation. FEBS Lett 2025 PubMed ID: 40040501 DOI: 10.1002/1873-3468.70020

22734 Ratman MF, Oogai Y, Matsumoto A, Nakata M. The ArcAB two-component system is associated with the susceptibility of Aggregatibacter actinomycetemcomitans to superoxide and hydrogen peroxide. mSphere 2025 e0001925 PubMed ID: 40237472 DOI: 10.1128/msphere.00019-25

22883 Lyu Q, Kouketsu Y, Tazaki A, Kato M, Motooka Y, Toyokuni S. Terrestrial iron sulfide minerals induce distinct regulation of intracellular redox homeostasis and iron assimilation. Ecotoxicol Environ Saf 2025 298:118327 PubMed ID: 40381394 DOI: 10.1016/j.ecoenv.2025.118327

19827 Yoshioka D, Nakamura T, Kubota Y, Takekawa M. Formation of the NLRP3 inflammasome inhibits stress granule assembly by multiple mechanisms J Biochem 2024 Jan 31:mvae009 PubMed ID: 38299728 DOI: 10.1093/jb/mvae009

21574 Kawakami K, Fukuda T, Toyoda M, Nakao Y, Hayashi C, Watanabe Y, Aoki T, Shinjo T, Iwashita M, Yamashita A, Shida M, Sanui T, Uchiumi T, Nishimura F. Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation. Biomed Res Int 2024 2024:8864513 PubMed ID: 38304347 DOI: 10.1155/2024/8864513

21592 Ito F, Yanatori I, Kato K, Toyokuni S. Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models. STAR Protoc 2024 5(1):102892 PubMed ID: 38363686 DOI: 10.1016/j.xpro.2024.102892

21650 Matsuo H, Inagami A, Ito Y, Ito N, Iyoda S, Harata Y, Higashitani M, Shoji K, Tanaka M, Noura M, Mikami T, Kato I, Takita J, Nakahata T, Adachi S. Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Commun Biol 2024 7(1):123 PubMed ID: 38267545 DOI: 10.1038/s42003-024-05811-8

21651 Tatsuno R, Ichikawa J, Komohara Y, Pan C, Kawasaki T, Enomoto A, Aoki K, Hayakawa K, Iwata S, Jubashi T, Haro H. Pivotal role of IL-8 derived from the interaction between osteosarcoma and tumor-associated macrophages in osteosarcoma growth and metastasis via the FAK pathway. Cell Death Dis 2024 15(2):108 PubMed ID: 38302407 DOI: 10.1038/s41419-024-06487-y

22152 Yamamori Y, Shirai R, Ohkura K, Nagamune H, Tomoyasu T, Tabata A. Streptolysin S induces proinflammatory cytokine expression in calcium ion-influx-dependent manner. Curr Res Microb Sci 2024 7:100265 PubMed ID: 39211836 DOI: 10.1016/j.crmicr.2024.100265

22268 Odawara T, Yamauchi S, Ichijo H. Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging Commun Biol 2024 7(1):691 PubMed ID: 38839869 DOI: 10.1038/s42003-024-06386-0

17688 Washisaka T, Tabata Y. Live Imaging of Monocyte/Macrophage Differentiation with Cationized Gelatin Nanospheres Incorporating a Molecular Beacon ACS Biomater Sci Eng 2023 Apr 4 PubMed ID: 37014020 DOI: 10.1021/acsbiomaterials.2c01420

19580 Murokawa H, Egusa K, Shibutani S, Iwata H. Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling is involved in phagocytosis activation during THP-1 cell differentiation J Vet Med Sci 2023 85(7):772-780 PubMed ID: 37225457 DOI: 10.1292/jvms.22-0504

19871 Yamada M, Nitta Y, Uehara T, Suzuki H, Miya F, Takenouchi T, Tamura M, Ayabe S, Yoshiki A, Maeno A, Saga Y, Furuse T, Yamada I, Okamoto N, Kosaki K, Sugie A. Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences Eur J Med Genet 2023 66(8):104804 PubMed ID: 37369308 DOI: 10.1016/j.ejmg.2023.104804

21116 Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y. Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins. Cells 2023 12(4) PubMed ID: 36831269 DOI: 10.3390/cells12040602

21363 Unzai T, Washisaka T, Tabata Y. An artificial silk elastin-like protein modifies the polarization of human macrophages line THP-1. J Biomater Appl 2023 8853282231192186 PubMed ID: 37494553 DOI: 10.1177/08853282231192186

21394 Egusa K, Shibutani S, Iwata H. IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K). Biochem Biophys Res Commun 2023 679:160-166 PubMed ID: 37696069 DOI: 10.1016/j.bbrc.2023.09.008

21518 Hirata W, Itatani Y, Masui H, Kawada K, Mizuno R, Yamamoto T, Okamoto T, Ogawa R, Inamoto S, Maekawa H, Okamura R, Kiyasu Y, Hanada K, Okamoto M, Nishikawa Y, Sugimoto N, Tamura T, Hatano E, Sakai Y, Obama K. Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage. Sci Rep 2023 13(1):22217 PubMed ID: 38097649 DOI: 10.1038/s41598-023-49312-w

22269 Pan Y, Ikoma K, Matsui R, Nakayama A, Takemura N, Saitoh T. Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation Front Pharmacol 2023 14:1250383 PubMed ID: 37705538 DOI: 10.3389/fphar.2023.1250383

17691 Ushio S, Wada Y, Nakamura M, Matsumoto D, Hoshika K, Shiromizu S, Iwata N, Esumi S, Kajizono M, Kitamura Y, Sendo T. Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition Front Pharmacol 2022 13:890048 PubMed ID: 36034871 DOI: 10.3389/fphar.2022.890048

20632 Kasai F, Hirayama N, Fukushima M, Kohara A, Nakamura Y. THP-1 reference data: proposal of an in vitro branched evolution model for cancer cell lines. Int J Cancer 2022 PubMed ID: 35373342 DOI: 10.1002/ijc.34019

16920 Ikegami H, Yamasaki K, Ogawa M, Nemoto K, Akata K, Noguchi S, Fukuda K, Kawanami T, Mukae H, Yatera K. Reduced phagocytic activity of human alveolar macrophages infected with Mycobacterium avium complex J Infect Chemother 2022 Aug 1 PubMed ID: 35926765 DOI: 10.1016/j.jiac.2022.07.018

16971 Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M. Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells Int J Mol Sci 2022 23(15):8660 PubMed ID: 35955793 DOI: 10.3390/ijms23158660

20842 Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H. Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76. J Oral Microbiol 2022 14(1):2105013 PubMed ID: 35937899 DOI: 10.1080/20002297.2022.2105013

20897 Ito M, Maejima Y, Nishimura K, Nakae Y, Ono A, Iwaki-Egawa S. A role for N-glycosylation in active adenosine deaminase 2 production. Biochim Biophys Acta Gen Subj 2022 1866(12):130237 PubMed ID: 36029899 DOI: 10.1016/j.bbagen.2022.130237

20957 Yokohata S, Ohkura K, Nagamune H, Tomoyasu T, Tabata A. Human serum albumin stabilizes streptolysin S activity secreted in the extracellular milieu by streptolysin S-producing streptococci. Microbiol Immunol 2022 PubMed ID: 36478453 DOI: 10.1111/1348-0421.13042

22598 Ikoma K, Takahama M, Kimishima A, Pan Y, Taura M, Nakayama A, Arai M, Takemura N, Saitoh T. Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung Int Immunol 2022 34(10):493-504 PubMed ID: 35639943 DOI: 10.1093/intimm/dxac018

13032 Kanai R, Nakashima A, Doi S, Kimura T, Yoshida K, Maeda S, Ishiuchi N, Yamada Y, Ike T, Doi T, Kato Y, Masaki T. Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis. Sci Rep 2021 PubMed ID: 33441701 DOI: 10.1038/s41598-020-79664-6

13296 Nakatani K, Matsuo H, Harata Y, Higashitani M, Koyama A, Noura M, Nishinaka-Arai Y, Kamikubo Y, Adachi S. Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells. Int J Hematol 2021 113(2):243-253 PubMed ID: 33068248 DOI: 10.1007/s12185-020-03015-4

13347 Fujita M, Yamamoto H, Yoshida N, Ono R, Matsuoka T, Kihara S. Atheroprotective Roles of Adiponectin via CCL2 Inhibition. J Atheroscler Thromb 2021 28(11):1204-1213 PubMed ID: 33191365 DOI: 10.5551/jat.58875

13382 Li H, Somiya M, Kuroda S. Enhancing antibody-dependent cellular phagocytosis by Re-education of tumor-associated macrophages with resiquimod-encapsulated liposomes. Biomaterials 2021 PubMed ID: 33338932 DOI: 10.1016/j.biomaterials.2020.120601

13541 Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, Iwasaki H. Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway Transl Res 2021 227:53-63 PubMed ID: 32687976 DOI: 10.1016/j.trsl.2020.07.005

20199 Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun 2021 12(1):3655 PubMed ID: 34135341 DOI: 10.1038/s41467-021-23969-1

20239 Kawakatsu K, Maemura M, Seta Y, Nishikata T. Involvement of Annexin A2 in Serum-MAF Dependent Phagocytic Activation of Macrophages. Anticancer Res 2021 41(8):4089-4092 PubMed ID: 34281879 DOI: 10.21873/anticanres.15211

15109 Minoru Sasaki, Yu Shimoyama, Yoshitoyo Kodama, Taichi Ishikawa Abiotrophia defectiva DnaK Promotes Fibronectin-Mediated Adherence to HUVECs and Induces a Proinflammatory Response International Journal of Molecular Sciences 2021 22(8528) PubMed ID: 34445234 DOI: 10.3390/ijms22168528

15492 Lee S, Ishitsuka A, Kuroki T, Lin YH, Shibuya A, Hongu T, Funakoshi Y, Kanaho Y, Nagata K, Kawaguchi A. Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes JCI Insight 2021 6(16):e139190 PubMed ID: 34423792 DOI: 10.1172/jci.insight.139190

20374 Kato S, Arasaki K, Tokutomi N, Imai Y, Inoshita T, Hattori N, Sasaki T, Sato M, Wakana Y, Inoue H, Tagaya M. Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms. J Cell Sci 2021 PubMed ID: 34704591 DOI: 10.1242/jcs.258699

20487 Sakamaki I, Fukushi M, Ohashi W, Tanaka Y, Itoh K, Tomihara K, Yamamoto Y, Iwasaki H. Sitafloxacin reduces tumor necrosis factor alpha (TNFα) converting enzyme (TACE) phosphorylation and activity to inhibit TNFα release from lipopolysaccharide-stimulated THP-1 cells. Sci Rep 2021 11(1):24154 PubMed ID: 34921186 DOI: 10.1038/s41598-021-03511-5

20490 Ito F, Kato K, Yanatori I, Murohara T, Toyokuni S. Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin. Redox Biol 2021 47:102174 PubMed ID: 34700146 DOI: 10.1016/j.redox.2021.102174

20561 Sasaki M, Shimoyama Y, Kodama Y, Ishikawa T. Tryptophanyl tRNA Synthetase from Human Macrophages Infected by Porphyromonas gingivalis Induces a Proinflammatory Response Associated with Atherosclerosis. Pathogens 2021 10(12) PubMed ID: 34959604 DOI: 10.3390/pathogens10121648

22332 Mukai A, Otsuki Y, Ito E, Fujita T, Ueno M, Maeda T, Kinoshita S, Sotozono C, Hamuro J. Mitochondrial miRNA494-3p in extracellular vesicles participates in cellular interplay of iPS-Derived human retinal pigment epithelium with macrophages Exp Eye Res 2021 208:108621 PubMed ID: 34000275 DOI: 10.1016/j.exer.2021.108621

10948 Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages Front Immunol 2020 11:709 PubMed ID: 32373130 DOI: 10.3389/fimmu.2020.00709

10952 Seiichi Sato, Kai Li, Nozomi Sakurai, Mei Hashizume, Sunanda Baidya, Hirotaka Nonaka, Koki Noguchi, Kozo Ishikawa, Chikashi Obuse, Akinori Takaoka Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections Cell Immunol 2020 356:104188 PubMed ID: 32763501 DOI: 10.1016/j.cellimm.2020.104188

12599 Kobayashi N, Oda T, Takizawa M, Ishizaki T, Tsukamoto N, Yokohama A, Takei H, Saitoh T, Shimizu H, Honma K, Kimura-Masuda K, Kuroda Y, Ishihara R, Murakami Y, Murakami H, Handa H. Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma Cancers (Basel) 2020 12(2):363 PubMed ID: 32033262 DOI: 10.3390/cancers12020363

13080 Ito F, Yanatori I, Maeda Y, Nimura K, Ito S, Hirayama T, Nagasawa H, Kohyama N, Okazaki Y, Akatsuka S, Toyokuni S. Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium. Redox Biol 2020 PubMed ID: 32863225 DOI: 10.1016/j.redox.2020.101616

13083 Matsushita M, Nakamura T, Moriizumi H, Miki H, Takekawa M. Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress. Sci Adv 2020 PubMed ID: 32637591 DOI: 10.1126/sciadv.aay9778

13133 Tabata A, Ohkuni H, Hino H, Saigo T, Kodama C, Tang Q, Tomoyasu T, Fukunaga Y, Itoh Y, Nagamune H. Cytotoxic property of Streptococcus mitis strain producing two different types of cholesterol-dependent cytolysins. Infect Genet Evol 2020 PubMed ID: 32731044 DOI: 10.1016/j.meegid.2020.104483

13143 Akamatsu M, Mashiba R, Kawakatsu K, Ishikawa M, Nishikata T. Comparison of Macrophage Activation Using γ-Globulin and Serum-derived Macrophage Activating Factor. Anticancer Res 2020 PubMed ID: 32727796 DOI: 10.21873/anticanres.14471

13307 Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y. CELF2 regulates the species-specific alternative splicing of TREM2. Sci Rep 2020 PubMed ID: 33093587 DOI: 10.1038/s41598-020-75057-x

13354 Noura M, Morita K, Kiyose H, Matsuo H, Nishinaka-Arai Y, Kurokawa M, Kamikubo Y, Adachi S. Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells. Sci Rep 2020 PubMed ID: 33219287 DOI: 10.1038/s41598-020-76951-0

13456 Hideo Kataoka, Ayumi Saeki, Akira Hasebe, Ken-ichiro Shibata, Takeshi Into Naringenin suppresses Toll-like receptor 2-mediated inflammatory responses through inhibition of receptor clustering on lipid rafts Food Sci Nutr 2020 PubMed ID: 33598179 DOI: 10.1002/fsn3.2063

4052 Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N. Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis Nat Commun 2019 10:1072 PubMed ID: 30842549 DOI: 10.1038/s41467-019-09028-w

11472 Suzuki S, Fukuda T, Nagayasu S, Nakanishi J, Yoshida K, Hirata-Tsuchiya S, Nakao Y, Sano T, Yamashita A, Yamada S, Ohta K, Shiba H, Nishimura F. Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles. Sci Rep 2019 PubMed ID: 30846715 DOI: 10.1038/s41598-019-40046-2

6911 Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H. β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro. J Oral Microbiol 2019 11(1):1609839. PubMed ID: 31105901 DOI: 10.1080/20002297.2019.1609839

6929 Minato KI, Laan LC, van Die I, Mizuno M. Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation. Int J Biol Macromol 2019 122:705-712 PubMed ID: 30392853 DOI: 10.1016/j.ijbiomac.2018.10.157

6943 Yamamoto M, Matsumura R, Hirata Y, Nagamune H. A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods. Toxicol In Vitro 2019 54:75-81 PubMed ID: 30240708 DOI: 10.1016/j.tiv.2018.09.009

10946 Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells Sci Rep 2019 9(1):8451 PubMed ID: 31186478 DOI: 10.1038/s41598-019-44817-9

12329 Iwashima T, Kudome Y, Kishimoto Y, Saita E, Tanaka M, Taguchi C, Hirakawa S, Mitani N, Kondo K, Iida K. Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3 Food Nutr Res 2019 16;63 PubMed ID: 31452653 DOI: 10.29219/fnr.v63.3361

12559 Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai TC, Nishiuchi T, Tanaka T, Barbie DA, Mukaida N, Takahashi C. Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion Cancer Res 2019 79(15):3903-3915 PubMed ID: 31189648 DOI: 10.1158/0008-5472.CAN-18-3604

12597 Horiguchi Y, Ohta N, Yamamoto S, Koide M, Fujino Y. Midazolam suppresses the lipopolysaccharide-stimulated immune responses of human macrophages via translocator protein signaling Int Immunopharmacol 2019 66:373-382. PubMed ID: 30530051 DOI: 10.1016/j.intimp.2018.11.050

12600 Giriwono PE, Shirakawa H, Ohsaki Y, Sato S, Aoyama Y, Ho HJ, Goto T, Komai M. Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells Int J Mol Sci 2019 20(9):2320 PubMed ID: 31083375 DOI: 10.3390/ijms20092320

10592 Yamazoe H. Multifunctional protein microparticles for medical applications. Biomaterials 2018 155:1-12 PubMed ID: 29154040 DOI: 10.1016/j.biomaterials.2017.10.045

11096 Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y, Sonoda Y. A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells. Nat Commun 2018 9(1):2202 PubMed ID: 29875383 DOI: 10.1038/s41467-018-04441-z

11176 Watanabe K, Suzuki H, Nishida T, Mishima M, Tachibana M, Fujishima M, Shimizu T, Watarai M. Identification of novel Legionella genes required for endosymbiosis in Paramecium based on comparative genome analysis with Holospora spp. FEMS Microbiol. Ecol. 2018 94(11) PubMed ID: 30124811 DOI: 10.1093/femsec/fiy162

11247 Zhitnyuk Y, Gee P, Lung MSY, Sasakawa N, Xu H, Saito H, Hotta A. Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30316514 DOI: 10.1016/j.bbrc.2018.09.113

11288 Segawa S, Kondo Y, Nakai Y, Iizuka A, Kaneko S, Yokosawa M, Furuyama K, Tsuboi H, Goto D, Matsumoto I, Sumida T. Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease. J. Immunol. 2018 PubMed ID: 30404814 DOI: 10.4049/jimmunol.1800667

4362 Nagai K, Domon H, Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y. Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell. Immunol. 2018 325:14-22 PubMed ID: 29366563 DOI: 10.1016/j.cellimm.2018.01.006

4363 Yoshino H, Konno H, Ogura K, Sato Y, Kashiwakura I. Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages. Int J Mol Sci 2018 PubMed ID: 30322167 DOI: 10.3390/ijms19103154

4364 Mashiba R, Ishikawa M, Sumiya YU, Kawakatsu K, Tran NK, Nishikata T. Phagocytic Activation of Macrophages with Serum MAF Depends on Engulfment Efficiency and Not Migratory Activity. Anticancer Res. 2018 38(7):4295-4298 PubMed ID: 29970564 DOI: 10.21873/anticanres.12727

4365 Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K. NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model. Mol Med Rep 2018 18(6):5279-5285 PubMed ID: 30320338 DOI: 10.3892/mmr.2018.9533

4366 Komoda H, Shiraki A, Oyama JI, Nishikido T, Node K. Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel. J. Atheroscler. Thromb. 2018 25(8):690-69 PubMed ID: 29398679 DOI: 10.5551/jat.41798

4506 Ebe H, Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T. Clinical and functional significance of STEAP4-splice variant in CD14⁺ monocytes in patients with rheumatoid arthritis. Clin. Exp. Immunol. 2018 191(3):338-348 PubMed ID: 29080328 DOI: 10.1111/cei.13076

4507 Yoshida K, Nakashima A, Doi S, Ueno T, Okubo T, Kawano KI, Kanawa M, Kato Y, Higashi Y, Masaki T. Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis. Stem Cells Transl Med 2018 7(12):893-905 PubMed ID: 30269426 DOI: 10.1002/sctm.17-0284

10181 Yoshino H, Kumai Y, Kashiwakura I. Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages. Mol Med Rep 2017 15:2867-2872 PubMed ID: 28447729 DOI: 10.3892/mmr.2017.6298

4520 Ken-ichiro Minato, Akihiro Ohara, and Masashi Mizuno A Proinflammatory Effect of the β-Glucan from Pleurotus cornucopiae Mushroom on Macrophage Action Mediators of Inflammation 2017 9 PubMed ID: 28611507 DOI: 10.1155/2017/8402405

4546 Arasaki K, Mikami Y, Shames SR, Inoue H, Wakana Y, Tagaya M. Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17. Nat Commun 2017 8:15406 PubMed ID: 28504273 DOI: 10.1038/ncomms15406

10964 Masataka Oda, Hisanori Domon, Mie Kurosawa, Toshihito Isono, Tomoki Maekawa, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao Streptococcus pyogenes Phospholipase A 2 Induces the Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells and Aorta of Mice Front Cell Infect Microbiol 2017 7:300 PubMed ID: 28713783 DOI: 10.3389/fcimb.2017.00300

14596 Yoshino H, Kashiwakura I. Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expression in human monocytic cells J Radiat Res 2017 58(5):626-635 PubMed ID: 28369600 DOI: 10.1093/jrr/rrx011

14666 Tabei Y, Sugino S, Eguchi K, Tajika M, Abe H, Nakajima Y, Horie M. Effect of calcium carbonate particle shape on phagocytosis and pro-inflammatory response in differentiated THP-1 macrophages Biochem Biophys Res Commun 2017 490(2):499-505 PubMed ID: 28624457 DOI: 10.1016/j.bbrc.2017.06.069

14711 Hojo K, Tamai R, Kobayashi-Sakamoto M, Kiyoura Y. Etidronate down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB activation Pharmacol Rep 2017 69(4):773-778 PubMed ID: 28587938 DOI: 10.1016/j.pharep.2017.03.009

7107 Yamazoe H, Ichikawa T, Hagihara Y, Iwasaki Y. Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells. Acta Biomater 2016 31:231-240 PubMed ID: 26685756 DOI: 10.1016/j.actbio.2015.12.016

9865 Seike S, Takehara M, Kobayashi K, Nagahama M. Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death. Biochim. Biophys. Acta 2016 1858:3150-3156 PubMed ID: 27720686 DOI: 10.1016/j.bbamem.2016.10.003

9972 Uchida H, Hasegawa Y, Takahashi H, Makishima M. 1α-Dihydroxyvitamin D3 and Retinoic Acid Increase Nuclear Vitamin D Receptor Expression in Monocytic THP-1 Cells. Anticancer Res. 2016 36:6297-6301 PubMed ID: 27919949 DOI: 10.21873/anticanres.11225

12919 Deo VK, Kato T, Park EY. Virus-Like Particles Displaying Recombinant Short-Chain Fragment Region and Interleukin 2 for Targeting Colon Cancer Tumors and Attracting Macrophages J Pharm Sci 2016 105(5):1614-1622 PubMed ID: 27037014 DOI: 10.1016/j.xphs.2016.02.011

12957 Kameoka S, Kameyama T, Hayashi T, Sato S, Ohnishi N, Hayashi T, Murata-Kamiya N, Higashi H, Hatakeyama M, Takaoka A. Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells Biomed Res 2016 37(1):21-7. PubMed ID: 26912137 DOI: 10.2220/biomedres.37.21

13972 Tanaka M, Kishimoto Y, Saita E, Suzuki-Sugihara N, Kamiya T, Taguchi C, Iida K, Kondo K. Terminalia bellirica Extract Inhibits Low-Density Lipoprotein Oxidation and Macrophage Inflammatory Response in Vitro Antioxidants (Basel) 2016 5(2):20 PubMed ID: 27314393 DOI: 10.3390/antiox5020020

14035 Sumiya YU, Inoue T, Ishikawa M, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T. Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors Anticancer Res 2016 36(7):3619-23. PubMed ID: 27354632

7231 Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S. The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory. Nat. Immunol. 2015 16:1034-43 PubMed ID: 26322480 DOI: 10.1038/ni.3257

7239 Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J. Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury. Biochim. Biophys. Acta 2015 1850:2159-67 PubMed ID: 26299247 DOI: 10.1016/j.bbagen.2015.08.011

7251 Yanagisawa K, Ogawa Y, Uchiumi H, Gohda F, Mawatari M, Ishizaki T, Mitsui T, Yokohama A, Handa H, Tsukamoto N, Nojima Y. Gene polymorphisms of mannose-binding lectin confer susceptibility to Pneumocystis pneumonia in HIV-infected patients. J. Infect. Chemother. 2015 21:769-75 PubMed ID: 26271591 DOI: 10.1016/j.jiac.2015.07.006

7288 Inoue T, Ishikawa M, Sumiya Y, Kohda H, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T. Establishment of a Macrophage-activating Factor Assay System Using the Human Monocytic Cell Line THP-1. Anticancer Res. 2015 35:4441-5 PubMed ID: 26168484

7316 Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R. Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury. Nat Commun 2015 6:7360 PubMed ID: 26059659 DOI: 10.1038/ncomms8360

7533 Jian Sun, Hiroko Shigemi, Yukie Tanaka, Takahiro Yamauchi, Takanori Ueda, Hiromichi Iwasaki Tetracyclines downregulate the production of LPS-induced cytokines and chemokines in THP-1 cells via ERK, p38, and nuclear factor-κB signaling pathways. Biochemistry and Biophysics Reports 2015 4:397-404 PubMed ID: 29124230 DOI: 10.1016/j.bbrep.2015.11.003

7556 S Yoshimatsu, T Kato-Matsumaru, A Aono, K Chikamatsu, H Yamada, S Mitarai Factors contribute to efficiency of specimen concentration of Mycobacterium tuberculosis by centrifugation and magnetic beads. International Journal of Mycobacteriology 2015 4:245-249 PubMed ID: 27649873 DOI: 10.1016/j.ijmyco.2015.05.014

10969 Takuya Shimizu, Yusuke Masuo, Saki Takahashi, Noritaka Nakamichi, Yukio Kato Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice Drug Metab Pharmacokinet 2015 30(3):231-9 PubMed ID: 26003890 DOI: 10.1016/j.dmpk.2015.02.003

15006 Nakayama S, Kishimoto Y, Saita E, Sugihara N, Toyozaki M, Taguchi C, Tani M, Kamiya T, Kondo K. Pine bark extract prevents low-density lipoprotein oxidation and regulates monocytic expression of antioxidant enzymes Nutr Res 2015 35(1):56-64 PubMed ID: 25458248 DOI: 10.1016/j.nutres.2014.10.010

15028 Inaba H, Yoshigai E, Okuyama T, Murakoshi M, Sugiyama K, Nishino H, Nishizawa M. Antipyretic analgesic drugs have different mechanisms for regulation of the expression of inducible nitric oxide synthase in hepatocytes and macrophages Nitric Oxide 2015 44:61-70 PubMed ID: 25499030 DOI: 10.1016/j.niox.2014.12.001

15175 Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity J Neurosci 2015 35(6):2452-64 PubMed ID: 25673840 DOI: 10.1523/JNEUROSCI.4088-14.2015

15442 Masanori Horie, Keiko Nishio, Haruhisa Kato, Shigehisa Endoh, Katsuhide Fujita, Ayako Nakamura, Arisa Miyauchi, Shinichi Kinugasa, Yoshihisa Hagihara, Yasukazu Yoshida, Hitoshi Iwahashi The Expression of Inflammatory Cytokine and Heme Oxygenase-1 Genes in THP-1 Cells Exposed to Metal Oxide Nanoparticles Journal of Nano Research 2015 30:116-127 DOI: 10.4028/www.scientific.net/jnanor.30.116

15454 Masanori Horie, Haruhisa Kato, Shigehisa Endoh, Ayako Nakamura, Junko Maru, Naohide Shinohara, Katsuhide Fujita Effects of Various Carbon Nanotube Suspensions on A549, THP-1, and Peritoneal Macrophage Cells Journal of Biomimetics, Biomaterials and Biomedical Engineering 2015 24:1-13 DOI: 10.4028/www.scientific.net/jbbbe.24.1

15479 Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K. GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy Sci Rep 2015 5:8327 PubMed ID: 25659802 DOI: 10.1038/srep08327

12955 Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mouriño, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds Journal of Medicinal Chemistry 2015 58:9510-9521 PubMed ID: 26613420 DOI: 10.1021/acs.jmedchem.5b00792

3320 Yoshino H, Saitoh T, Kozakai M, Kashiwakura I. Effects of ionizing radiation on retinoic acid-inducible gene-I-like receptors Biomed Rep 2015 3(1):59-62 PubMed ID: 25469248 DOI: 10.3892/br.2014.377

18177 Okada M, Matsuzawa A, Yoshimura A, Ichijo H. The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation J Biol Chem 2014 289(47):32926-36 PubMed ID: 25288801 DOI: 10.1074/jbc.M114.579961

19377 Kubota M, Nakanishi S, Hirano M, Maeda S, Yoneda M, Awaya T, Yamane K, Kohno N. Relationship between serum cholesterol efflux capacity and glucose intolerance in Japanese-Americans J Atheroscler Thromb 2014 21(10):1087-97 PubMed ID: 24942406 DOI: 10.5551/jat.24315

5633 Tung NH, Suzuki M, Uto T, Morinaga O, Kwofie KD, Ammah N, Koram KA, Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y. Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica. Am J Chin Med 2014 42(5):1245-60 PubMed ID: 25178281 DOI: 10.1142/S0192415X14500785

6468 Takahashi H, Hatta Y, Iriyama N, Hasegawa Y, Uchida H, Nakagawa M, Makishima M, Takeuchi J, Takei M. Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3. PLoS One 2014 9(11):e113722 PubMed ID: 25409436 DOI: 10.1371/journal.pone.0113722

15308 Hayashi Y, Kuroda T, Kishimoto H, Wang C, Iwama A, Kimura K. Downregulation of rRNA transcription triggers cell differentiation PLoS One 2014 9(5):e98586 PubMed ID: 24879416 DOI: 10.1371/journal.pone.0098586

16008 Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T, Suzuki M, Kimoto M, Sasabe S, Fukushima M, Kishimoto K, Izumi T, Oga T, Narumiya S, Sugahara M, Miyano M, Yamamoto S, Takahashi Y. Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies Biochim Biophys Acta 2014 1840(6):1625-33 PubMed ID: 24361619 DOI: 10.1016/j.bbagen.2013.12.016

17167 Fukushi Y , Yoshino H , Ishikawa J , Sagisaka M , Kashiwakura I , Yoshizawa A . Synthesis and anticancer properties of phenyl benzoate derivatives possessing a terminal hydroxyl group J Mater Chem B 2014 2(10):1335-1343 PubMed ID: 32261448 DOI: 10.1039/c3tb21736a

18663 Miyamoto-Sasaki M, Yasuda T, Monguchi T, Nakajima H, Mori K, Toh R, Ishida T, Hirata K. Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients J Atheroscler Thromb 2013 20(9):708-16 PubMed ID: 23739642 DOI: 10.5551/jat.17210

9097 Masahiro Nagahama, Masahiro Shibutani, Soshi Seike, Mami Yonezaki, Teruhisa Takagishi, Masataka Oda, Keiko Kobayashi, Jun Sakurai The p38 MAPK and JNK Pathways Protect Host Cells Against Clostridium Perfringens Beta-Toxin Infect Immun 2013 81 (10), 3703-8 PubMed ID: 23876806 DOI: 10.1128/IAI.00579-13

15772 Masanori Saito, Osamu Tsuzukibashi, Noriko Shinozaki-Kuwahara, Taira Kobayashi, Kazuko Takada Anticytotoxic Effect of Green Tea Catechin on Lipopolysaccharide from Aggregatibacter actinomycetemcomitans International Journal of Oral-Medical Sciences 2013 11:202-206 DOI: 10.5466/ijoms.11.202

15795 Wang X, Li X, Onuma K, Sogo Y, Ohno T, Ito A. Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy Sci Rep 2013 3:2203 PubMed ID: 23857555 DOI: 10.1038/srep02203

15933 Koyama T, Sun B, Tokunaga K, Tatsumi M, Ishizaka Y. DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition Retrovirology 2013 10:21 PubMed ID: 23432899 DOI: 10.1186/1742-4690-10-21

17159 Oya K, Sakamoto N, Sato M. Hypoxia suppresses stretch-induced elongation and orientation of macrophages Biomed Mater Eng 2013 23(6):463-71 PubMed ID: 24165549 DOI: 10.3233/BME-130770

7638 Satoh J, Shimamura Y, Tabunoki H. Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease. Cell. Mol. Neurobiol. 2012 32:337-43 PubMed ID: 22080356 DOI: 10.1007/s10571-011-9769-z

18999 Matsunawa M, Akagi D, Uno S, Endo-Umeda K, Yamada S, Ikeda K, Makishima M. Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages Drug Metab Dispos 2012 40(11):2059-66 PubMed ID: 22837390 DOI: 10.1124/dmd.112.046839

6091 Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T. Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages. Microbes Infect 2012 14(11):916-21 PubMed ID: 22561467 DOI: 10.1016/j.micinf.2012.04.015

10968 Hiroharu Kobayashi, Yoriko Yamashita, Akira Iwase, Yutaka Yoshikawa, Hiroyuki Yasui, Yoshichika Kawai, Koji Uchida, Nozomi Uno, Shinya Akatsuka, Takashi Takahashi, Fumitaka Kikkawa, Shinya Toyokuni The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis Fertil Steril 2012 98(2):415-22.e1-12 PubMed ID: 22633261 DOI: 10.1016/j.fertnstert.2012.04.047

12723 Daniele E, Govoni S, Lograno MD. The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation Biochim Biophys Acta 2012 1820(11):1753-63 PubMed ID: 22842481 DOI: 10.1016/j.bbagen.2012.07.007

15343 Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K. Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages J Nutr Sci Vitaminol (Tokyo) 2012 58(2):96-104 PubMed ID: 22790567 DOI: 10.3177/jnsv.58.96

7695 Kanai Y, Hiroki S, Koshino H, Konoki K, Cho Y, Cayme M, Fukuyo Y, Yotsu-Yamashita M. Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue. J. Lipid Res. 2011 52:2245-54 PubMed ID: 21893678 DOI: 10.1194/jlr.M017053

7701 Oya K, Sakamoto N, Ohashi T, Sato M. Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages. Biochem. Biophys. Res. Commun. 2011 412:678-82 PubMed ID: 21867689 DOI: 10.1016/j.bbrc.2011.08.024

7813 Taira M, Shimoyama Y, Kagiya T, Sasaki M, Nezu T, Harada H, Kimura S. Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions. Dent Mater J 2011 30:293-9 PubMed ID: 21597227 DOI: 10.4012/dmj.2010-088

7886 Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara E, Suekane A, Morishita K. CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression. Leukemia 2011 25:921-31 PubMed ID: 21394097 DOI: 10.1038/leu.2011.36

8120 Mizuno K, Toyoda Y, Fukami T, Nakajima M, Yokoi T. Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway. Arch. Toxicol. 2011 85:199-207 PubMed ID: 20848085 DOI: 10.1007/s00204-010-0584-y

5413 Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H. Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines. Int J Nanomedicine 2011 6:3487-97 PubMed ID: 22267932 DOI: 10.2147/IJN.S26689

9085 Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli Gene 2011 478 (1-2), 1-10 PubMed ID: 21262333 DOI: 10.1016/j.gene.2011.01.006

13999 Okahashi N, Okinaga T, Sakurai A, Terao Y, Nakata M, Nakashima K, Shintani S, Kawabata S, Ooshima T, Nishihara T. Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species FEMS Microbiol Lett 2011 323(2):164-70 PubMed ID: 22092716 DOI: 10.1111/j.1574-6968.2011.02375.x

16309 Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, Saito N. DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes Int J Nanomedicine 2011 6:2689-95 PubMed ID: 22114499 DOI: 10.2147/IJN.S25471

8130 Mizuno K, Fukami T, Toyoda Y, Nakajima M, Yokoi T. Terbinafine stimulates the pro-inflammatory responses in human monocytic THP-1 cells through an ERK signaling pathway. Life Sci. 2010 87:537-44 PubMed ID: 20816994 DOI: 10.1016/j.lfs.2010.08.010

8148 Nakaya K, Ayaori M, Uto-Kondo H, Hisada T, Ogura M, Yakushiji E, Takiguchi S, Terao Y, Ozasa H, Sasaki M, Komatsu T, Ohsuzu F, Ikewaki K. Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo. Atherosclerosis 2010 213:135-41 PubMed ID: 20723893 DOI: 10.1016/j.atherosclerosis.2010.07.024

8264 Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M. Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors. Biol. Pharm. Bull. 2010 33:854-61 PubMed ID: 20460766 DOI: 10.1248/bpb.33.854

8393 Uto-Kondo H, Ayaori M, Ogura M, Nakaya K, Ito M, Suzuki A, Takiguchi S, Yakushiji E, Terao Y, Ozasa H, Hisada T, Sasaki M, Ohsuzu F, Ikewaki K. Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages. Circ. Res. 2010 106:779-87 PubMed ID: 20075335 DOI: 10.1161/CIRCRESAHA.109.206615

8402 Iizuka M, Tani M, Kishimoto Y, Saita E, Toyozaki M, Kondo K. Inhibitory effects of balsamic vinegar on LDL oxidation and lipid accumulation in THP-1 macrophages. J. Nutr. Sci. Vitaminol. 2010 56:421-7 PubMed ID: 21422711 DOI: 10.3177/jnsv.56.421

8413 Lu X, Ohata K, Kondo Y, Espinoza JL, Qi Z, Nakao S. Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis. Cancer Sci. 2010 101:609-15 PubMed ID: 20028385 DOI: 10.1111/j.1349-7006.2009.01439.x

8526 Taira M, Kagiya T, Harada H, Sasaki M, Kimura S, Narushima T, Nezu T, Araki Y. Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles. J Mater Sci Mater Med 2010 21:267-75 PubMed ID: 19644653 DOI: 10.1007/s10856-009-3834-x

6125 Shimahara A, Yamakawa N, Nishikata I, Morishita K. Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2. J Biol Chem 2010 285(22):16967-77 PubMed ID: 20363750 DOI: 10.1074/jbc.M110.102046

9080 Akihiro Unno, Katsuya Kitoh, Yasuhiro Takashima Up-regulation of Hyaluronan Receptors in Toxoplasma Gondii-Infected Monocytic Cells Biochem Biophys Res Commun 2010 391 (1), 477-80 PubMed ID: 19914206 DOI: 10.1016/j.bbrc.2009.11.083

11006 Kaku Sawada, Shigeru Ariki, Takashi Kojima, Atsushi Saito, Masami Yamazoe, Chiaki Nishitani, Takeyuki Shimizu, Motoko Takahashi, Hiroaki Mitsuzawa, Shin-Ichi Yokota, Norimasa Sawada, Nobuhiro Fujii, Hiroki Takahashi, Yoshio Kuroki Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth J Biol Chem 2010 285(11):8434-43 PubMed ID: 20056602 DOI: 10.1074/jbc.M109.074765

8535 Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Higuchi K, Takeuchi K, Arakawa T. Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid. Am. J. Physiol. Gastrointest. Liver Physiol. 2009 297:G506-13 PubMed ID: 19589943 DOI: 10.1152/ajpgi.90553.2008

8547 Hojo-Nakashima I, Sato R, Nakashima K, Hagiwara T, Yamada M. Dynamic expression of peptidylarginine deiminase 2 in human monocytic leukaemia THP-1 cells during macrophage differentiation. J. Biochem. 2009 146:471-9 PubMed ID: 19564157 DOI: 10.1093/jb/mvp097

8564 Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, Furusawa K, Kurihara S, Wang PL. Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. J. Periodont. Res. 2009 44:21-7 PubMed ID: 19515019 DOI: 10.1111/j.1600-0765.2007.01041.x

8579 Amano Y, Cho Y, Matsunawa M, Komiyama K, Makishima M. Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells. J. Steroid Biochem. Mol. Biol. 2009 114:144-51 PubMed ID: 19429444 DOI: 10.1016/j.jsbmb.2009.01.022

8604 Matsuki K, Tamasawa N, Yamashita M, Tanabe J, Murakami H, Matsui J, Imaizumi T, Satoh K, Suda T. Metformin restores impaired HDL-mediated cholesterol efflux due to glycation. Atherosclerosis 2009 206:434-8 PubMed ID: 19376519 DOI: 10.1016/j.atherosclerosis.2009.03.003

8616 Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M. Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells. Biol. Pharm. Bull. 2009 32:564-72 PubMed ID: 19336885 DOI: 10.1248/bpb.32.564

6132 Naito H, Kidoya H, Sato Y, Takakura N. Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population. J Biochem 2009 145(5):653-9 PubMed ID: 19179360 DOI: 10.1093/jb/mvp021

6303 Taira M, Nezu T, Sasaki M, Kimura S, Kagiya T, Harada H, Narushima T, Araki Y. Gene expression analyses of human macrophage phagocytizing sub-micro titanium particles by allergy DNA chip (Genopal). Biomed Mater Eng 2009 19(1):63-70 PubMed ID: 19458447 DOI: 10.3233/BME-2009-0564

16152 Ikegaya S, Inai K, Iwasaki H, Naiki H, Ueda T. Azithromycin reduces tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells by modification of stress response and p38 MAPK pathway J Chemother 2009 21(4):396-402 PubMed ID: 19622457 DOI: 10.1179/joc.2009.21.4.396

16561 Enomoto H, Hayashi Y, Li CP, Ohki S, Ohtomo H, Shiokawa M, Aoki T. Glycation and phosphorylation of alpha-lactalbumin by dry heating: effect on protein structure and physiological functions J Dairy Sci 2009 92(7):3057-68 PubMed ID: 19528583 DOI: 10.3168/jds.2009-2014

16562 Inafuku Y, Furuhata T, Tayama M, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K. Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer Cancer Sci 2009 100(5):852-8 PubMed ID: 19445018 DOI: 10.1111/j.1349-7006.2009.01116.x

8700 Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K. Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice. Biosci. Biotechnol. Biochem. 2008 72:3148-57 PubMed ID: 19060399 DOI: 10.1271/bbb.80324

18734 Haraguchi G, Kosuge H, Maejima Y, Suzuki J, Imai T, Yoshida M, Isobe M. Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis Intensive Care Med 2008 34(7):1304-12 PubMed ID: 18283431 DOI: 10.1007/s00134-008-1024-9

18998 Nakayama K, Nitto T, Inoue T, Node K. Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes Life Sci 2008 ;83(9-10):339-45 PubMed ID: 18675280 DOI: 10.1016/j.lfs.2008.06.026

5403 Hirasawa A, Itsubo C, Sadakane K, Hara T, Shinagawa S, Koga H, Nose H, Koshimizu TA, Tsujimoto G. Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1). Biochem Biophys Res Commun 2008 365:22-8 PubMed ID: 17980148 DOI: 10.1016/j.bbrc.2007.10.142

3586 Haga A, Funasaka T, Deyashiki Y, Raz A. Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway. FEBS Lett. 2008 582(13):1877-82 PubMed ID: 18485900 DOI: 10.1016/j.febslet.2008.05.005

6804 Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T. Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivatio Biochem Biophys Res Commun 2008 374(4):683-7 PubMed ID: 18662673 DOI: 10.1016/j.bbrc.2008.07.090

6296 Shimadoi S, Takami A, Kondo Y, Okumura H, Nakao S. Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes. Cancer Sci 2007 98(9):1368-72 PubMed ID: 17640305 DOI: 10.1111/j.1349-7006.2007.00544.x

10072 Yoshinari Uehara 1, Shin-ichiro Miura, Arnold von Eckardstein, Satomi Abe, Akihiro Fujii, Yoshino Matsuo, Stephan Rust, Stefan Lorkowski, Gerd Assmann, Tatsuo Yamada, Keijiro Saku Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element Atherosclerosis 2007 191(1):11-21 PubMed ID: 16730733 DOI: 10.1016/j.atherosclerosis.2006.04.018

15379 Kentaro Harutsugu, Kyoko Watanabe, Michiharu Daito The role of anti immune response on adenosine stimulated macrophages Pediatric Dental Journal 2007 1:40-46 DOI: 10.11411/pdj.17.40

8818 Matsumoto E, Hatanaka M, Bohgaki M, Maeda S. PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells. Kobe J Med Sci 2006 52:181-94 PubMed ID: 17329956

8914 Hisakage Funabashi, Riko Matsuzawaa, Makiko Nakamura, Masayasu Mie and Eiry Kobatake Bioluminescent enumeration of surface antigen-specific cells using the streptavidin?luciferase fusion protein Sensors and Actuators B: Chemical 2006 120:51-56 DOI: 10.1016/j.snb.2006.01.042

18569 Besson N, Hullin-Matsuda F, Makino A, Murate M, Lagarde M, Pageaux JF, Kobayashi T, Delton-Vandenbroucke I. Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages Lipids 2006 41(2):189-96 PubMed ID: 17707985 DOI: 10.1007/s11745-006-5087-5

18802 Tachiwana H, Shimura M, Nakai-Murakami C, Tokunaga K, Takizawa Y, Sata T, Kurumizaka H, Ishizaka Y. HIV-1 Vpr induces DNA double-strand breaks Cancer Res 2006 66(2):627-31 PubMed ID: 16423988 DOI: 10.1158/0008-5472.CAN-05-3144

3538 Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, Miyazawa M, Ito Y, Suzuki H, Toyoda H. Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol. Toxicol In Vitro 2006 20(5):767-73 PubMed ID: 16311011 DOI: 10.1016/j.tiv.2005.10.012

3539 Sakaguchi H, Ashikaga T, Miyazawa M, Yoshida Y, Ito Y, Yoneyama K, Hirota M, Itagaki H, Toyoda H, Suzuki H. Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT. Toxicol In Vitro 2006 20(5):774-84 PubMed ID: 16337770 DOI: 10.1016/j.tiv.2005.10.014

3393 Isse, Kumiko, Harada, Kenichi, Zen, Yoh, Kamihira, Takashi, Shimoda, Shinji, Harada, Mine, Nakanuma, Yasuni Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology 2005 41:506-16 PubMed ID: 15726664 DOI: 10.1002/hep.20582

3270 Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y. Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Hepatol. Res. 2005 33:198-205 PubMed ID: 16198622 DOI: 10.1016/j.hepres.2005.08.005

18800 Mizoguchi I, Ooe Y, Hoshino S, Shimura M, Kasahara T, Kano S, Ohta T, Takaku F, Nakayama Y, Ishizaka Y. Improved gene expression in resting macrophages using an oligopeptide derived from Vpr of human immunodeficiency virus type-1 Biochem Biophys Res Commun 2005 338(3):1499-506 PubMed ID: 16274667 DOI: 10.1016/j.bbrc.2005.10.112

2862 Liu Y, Yang H, Otaka K, Takatsuki H, Sakanishi A. Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration. Colloids Surf B Biointerfaces 2005 43(3-4):216-20 PubMed ID: 15978788 DOI: 10.1016/j.colsurfb.2005.04.011

2938 Harada H, Suzu S, Hayashi Y, Okada S. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. J Cell Physiol 2005 204(3):919-26 PubMed ID: 15795899 DOI: 10.1002/jcp.20361

3076 Sumita C, Yamane M, Matsuda T, Maeda M, Nariai T, Fujio Y, Azuma J. Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. FEBS Lett 2005 579(18):4038-42. PubMed ID: 16004986 DOI: 10.1016/j.febslet.2005.06.022

3349 Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, Yamanaka M, Eda S, Beppu M. A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells. J Biol Chem 2005 280(47):39284-93 PubMed ID: 16135517 DOI: 10.1074/jbc.M505275200

16563 Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells J Immunol 2005 174(3):1566-73 PubMed ID: 15661917 DOI: 10.4049/jimmunol.174.3.1566

3075 Sumita C, Maeda M, Fujio Y, Kim J, Fujitsu J, Kasayama S, Yamamoto I, Azuma J. Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. Biochim Biophys Acta 2004 1673(3):115-21 PubMed ID: 15279882 DOI: 10.1016/j.bbagen.2004.04.002

3195 Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K, Maeda K, Nagaretani H, Kishida K, Maeda N, Nagasawa A, Funahashi T, Matsuzawa Y. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 2004 109(17):2046-9 PubMed ID: 15096450 DOI: 10.1161/01.CIR.0000127953.98131.ED

3074 Maeda M, Yamamoto I, Fujio Y, Azuma J. Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages. Biochim Biophys Acta 2003 1623(1):41-6 PubMed ID: 12957716 DOI: 10.1016/s0304-4165(03)00161-2

15589 Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K. An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis Nat Genet 2003 35(4):341-8 PubMed ID: 14608356 DOI: 10.1038/ng1267

9032 N Kiyokawa, T Mori, T Taguchi, M Saito, K Mimori, T Suzuki, T Sekino, N Sato, H Nakajima, Y U Katagiri, T Takeda, J Fujimoto Activation of the Caspase Cascade During Stx1-induced Apoptosis in Burkitt's Lymphoma Cells J Cell Biochem 2001 81 (1), 128-42 PubMed ID: 11180403 DOI: 10.1002/1097-4644(20010401)81:1<128::aid-jcb1029>3.0.co;2-g

10997 K Fukuda, S Akao, Y Ohno, K Yamashita, H Fujiwara Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1 Cancer Lett 2001 164(1):7-13 PubMed ID: 11166910 DOI: 10.1016/s0304-3835(00)00704-7

16967 Misumi S, Nakajima R, Takamune N, Shoji S. A cyclic dodecapeptide-multiple-antigen peptide conjugate from the undecapeptidyl arch (from Arg(168) to Cys(178)) of extracellular loop 2 in CCR5 as a novel human immunodeficiency virus type 1 vaccine J Virol 2001 11614-20 PubMed ID: 11689643 DOI: 10.1128/JVI.75.23.11614-11620.2001

11022 K Fukuda, Y Hibiya, M Mutoh, Y Ohno, K Yamashita, S Akao, H Fujiwara Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1 Biochem Pharmacol 2000 60(4):595-600 PubMed ID: 10874135 DOI: 10.1016/s0006-2952(00)00340-3

2378 Yamasaki K, Sasaki T, Nemoto M, Eto Y, Tajima N Differentiation-induced insulin secretion from nonendocrine cells with engineered human proinsulin cDNA. Biochem Biophys Res Commun 1999 265:361-5 PubMed ID: 10558872 DOI: 10.1006/bbrc.1999.1698

17220 Fujii H, Nakajima M, Aoyagi T, Tsuruo T. Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors Biol Pharm Bull 1996 19(1):6-10 PubMed ID: 8820902 DOI: 10.1248/bpb.19.6