細胞番号 : 細胞名
RCB1186 : TGBC14TKB
update : 2022/03/30
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| 細胞特性(Comment:英) | Japanese gallbladder tumor passed through a nude mouse. Application consideration |
| 細胞特性(日) | 日本人胆嚢癌。原発癌をヌードマウスに移植し、そこから培養。培養開始にあたっての注意 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Todoroki, T. & Ohno, T.
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| 樹立者 |
Todoroki, T. & Ohno, T. & Kim, B.
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| 寄託日 |
1995
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| 別名 |
AkAs
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| 動物種 |
_human
< Mammals
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| 属名 |
Homo
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| 種名 |
sapiens
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| 人種 |
Japanese
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| 性別 |
Female
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| 採取組織 |
gallbladder
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| 細胞分類 |
cancer
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| 初代培養日 |
1995
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|
細胞寿命 |
infinite
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| 細胞形態 |
epithelial-like
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| Cellosaurus(Expasy) |
CVCL_3340
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Adherent cells
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| 培地 |
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DMEM (low glucose) + 10% FBS
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| 抗生物質 |
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Free
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継代方法 |
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0.25% Trypsin
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|
継代密度 |
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1 : 8 split
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| 継代・培地交換頻度 |
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Subculture : once/1-2 weeks, Medium Renewal : 2 times/week
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| 培養最適温度 |
|
37
℃
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| 二酸化炭素濃度 |
|
5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ/アコレプラズマ |
|
(-)
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| ウィルス（HIV) |
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(-)
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| ウィルス（HBV) |
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(-)
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| ウィルス（HCV) |
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(-)
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| アイソザイム検査 |
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LD, NP
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| 染色体検査 |
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58-65(50) : /59(2),60(7),61(20),62(14),63(4),64(1)/
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| 個体識別検査 |
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OK
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| 画像情報 |
寄託時情報 | ロット情報 |
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| 文献情報 |
Reference(英) |
4件
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| Reference(日) |
4件
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| 利用者成果(英) |
16件
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| 利用者成果(日) |
0件
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| Reference(英) |
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2324
Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK.
E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers
Clin Cancer Res
2007
13(10):3043-50
PubMed ID: 17505007
DOI: 10.1158/1078-0432.CCR-06-2103
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2673
Ghosh, Mila, Koike, Naoto, Yanagimoto, Go, Tsunoda, Shin-Ichi, Kaul, Sunil, Hirano, Takashi, Emura, Fabian, Kashiwagi, Hironobu, Kawamoto, Toru, Ohkohchi, Nobuhiro, Saijo, Kaoru, Ohno, Tadao, Miwa, Masanao, Todoroki, Takeshi
Establishment and characterization of unique human gallbladder cancer cell lines.
Int J Oncol
2004
24:1189-96
PubMed ID: 15067341
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2319
Koike N, Todoroki T, Kawamoto T, Yoshida S, Kashiwagi H, Fukao K, Ohno T, Watanabe T
The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics.
Int J Oncol
1998
13:1269-74
PubMed ID: 9824643
DOI: 10.3892/ijo.13.6.1269
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2237
Moon,Y., Dahlberg,W. K., Yu,Y., Ohno,T. Todoroki,T., and Little,J. B.
Radiosensitivity of human biliary tract cancer cell lines in vitro
Int J Oncol
1997
10:545-551
PubMed ID: 21533411
DOI: 10.3892/ijo.10.3.545
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| 利用者成果(英) |
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13778
Yamashita T, Kato K, Fujihara S, Iwama H, Morishita A, Yamana H, Kobayashi K, Kamada H, Chiyo T, Kobara H, Tsutsui K, Okano K, Suzuki Y, Masaki T.
Anti-diabetic drug metformin inhibits cell proliferation and tumor growth in gallbladder cancer via G0/G1 cell cycle arrest
Anticancer Drugs
2020
31(3):231-240
PubMed ID: 31815765
DOI: 10.1097/CAD.0000000000000870
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20122
Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, Chiquet-Ehrismann R.
Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.
Front Immunol
2020
11:630139
PubMed ID: 33692777
DOI: 10.3389/fimmu.2020.630139
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3738
Yamashita-Kashima Y, Yoshimura Y, Fujimura T, Shu S, Yanagisawa M, Yorozu K, Furugaki K, Higuchi R, Shoda J, Harada N.
Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.
Cancer Chemother Pharmacol.
2019
83(4):659-671
PubMed ID: 30659304
DOI: 10.1007/s00280-019-03768-8
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10222
Yang L, Huang S, Ma H, Wu X, Feng F.
MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer.
Tumour Biol.
2017
39:1010428317692249
PubMed ID: 28347246
DOI: 10.1177/1010428317692249
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3727
Yeung Y, Lau DK, Chionh F, Tran H, Tse JWT, Weickhardt AJ, Nikfarjam M, Scott AM, Tebbutt NC, Mariadason JM
K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
Mol Oncol
2017
11(9):1130-1142
PubMed ID: 28544747
DOI: 10.1002/1878-0261.12078
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3735
Saha SK et al
Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.
Cancer Discov
2016
6(7):727-39
PubMed ID: 27231123
DOI: 10.1158/2159-8290.CD-15-1442
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3709
Kawamoto T, Ishige K, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J.
Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.
J Gastroenterol
2015
50(4):467-79
PubMed ID: 25112701
DOI: 10.1007/s00535-014-0984-5
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13739
Letelier P, García P, Leal P, Álvarez H, Ili C, López J, Castillo J, Brebi P, Roa JC.
miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer
Int J Clin Exp Pathol
2014
7(5):1849-67
PubMed ID: 24966896
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14930
Takahashi N, Aoyama F, Hiyoshi M, Kataoka H, Sawaguchi A.
Establishment and biological characterization of a novel cell line derived from hepatoid adenocarcinoma originated at the ampulla of Vater
Int J Oncol
2014
44(4):1139-45
PubMed ID: 24481592
DOI: 10.3892/ijo.2014.2282
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3722
Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.
Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.
Cancer Sci
2012
103(2):252-61
PubMed ID: 22044563
DOI: 10.1111/j.1349-7006.2011.02138.x
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7862
Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M.
Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.
J Hepatobiliary Pancreat Sci
2011
18:700-11
PubMed ID: 21451941
DOI: 10.1007/s00534-011-0376-7
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3705
Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.
Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.
World J Gastroenterol
2009
15(31):3865-73
PubMed ID: 19701966
DOI: 10.3748/wjg.15.3865
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18693
Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S.
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
Gastroenterology
2008
135(4):1358-1368
PubMed ID: 18692501
DOI: 10.1053/j.gastro.2008.06.082
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5903
Kamoshida S, Suzuki M, Sakurai Y, Ochiai M, Kimura F, Kuwao S, Sakamoto K, Sugimoto Y, Fukushima M, Tsutsumi Y.
Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs.
Oncol Rep
2006
16(4):721-7
PubMed ID: 16969485
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3700
Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y.
Expression of homeodomain protein CDX2 in gallbladder carcinomas.
J Cancer Res Clin Oncol
2005
131(5):271-8
PubMed ID: 15645288
DOI: 10.1007/s00432-004-0658-4
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13755
Asakura T, Imai A, Ohkubo-Uraoka N, Kuroda M, Iidaka Y, Uchida K, Shibasaki T, Ohkawa K.
Relationship between expression of drug-resistance factors and drug sensitivity in normal human renal proximal tubular epithelial cells in comparison with renal cell carcinoma
Oncol Rep
2005
14(3):601-7.
PubMed ID: 16077962
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