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Cell No. : Cell Name
RCB1186 : TGBC14TKB  update : 2022/03/30
CommentJapanese gallbladder tumor passed through a nude mouse. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Todoroki, T. & Ohno, T.
Originator Todoroki, T. & Ohno, T. & Kim, B.
Year of deposit 1995
Another name AkAs
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Tissue gallbladder
Classification cancer
Year of origin 1995
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_3340
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/1-2 weeks, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 58-65(50) : /59(2),60(7),61(20),62(14),63(4),64(1)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 16


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Reference
2324  Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK.  E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers  Clin Cancer Res  2007  13(10):3043-50  PubMed ID: 17505007   DOI: 10.1158/1078-0432.CCR-06-2103
2673  Ghosh, Mila, Koike, Naoto, Yanagimoto, Go, Tsunoda, Shin-Ichi, Kaul, Sunil, Hirano, Takashi, Emura, Fabian, Kashiwagi, Hironobu, Kawamoto, Toru, Ohkohchi, Nobuhiro, Saijo, Kaoru, Ohno, Tadao, Miwa, Masanao, Todoroki, Takeshi  Establishment and characterization of unique human gallbladder cancer cell lines.  Int J Oncol  2004  24:1189-96  PubMed ID: 15067341  
2319  Koike N, Todoroki T, Kawamoto T, Yoshida S, Kashiwagi H, Fukao K, Ohno T, Watanabe T  The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics.  Int J Oncol  1998  13:1269-74  PubMed ID: 9824643   DOI: 10.3892/ijo.13.6.1269
2237  Moon,Y., Dahlberg,W. K., Yu,Y., Ohno,T. Todoroki,T., and Little,J. B.   Radiosensitivity of human biliary tract cancer cell lines in vitro  Int J Oncol  1997  10:545-551  PubMed ID: 21533411   DOI: 10.3892/ijo.10.3.545

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User's Publication
13778  Yamashita T, Kato K, Fujihara S, Iwama H, Morishita A, Yamana H, Kobayashi K, Kamada H, Chiyo T, Kobara H, Tsutsui K, Okano K, Suzuki Y, Masaki T.  Anti-diabetic drug metformin inhibits cell proliferation and tumor growth in gallbladder cancer via G0/G1 cell cycle arrest  Anticancer Drugs  2020  31(3):231-240  PubMed ID: 31815765   DOI: 10.1097/CAD.0000000000000870
20122  Hendaoui I, Lahmar A, Campo L, Mebarki S, Bichet S, Hess D, Degen M, Kchir N, Charrada-Ben Farhat L, Hefaiedh R, Ruiz C, Terracciano LM, Tucker RP, Hendaoui L, Chiquet-Ehrismann R.  Tenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.  Front Immunol  2020  11:630139  PubMed ID: 33692777   DOI: 10.3389/fimmu.2020.630139
3738  Yamashita-Kashima Y, Yoshimura Y, Fujimura T, Shu S, Yanagisawa M, Yorozu K, Furugaki K, Higuchi R, Shoda J, Harada N.  Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.  Cancer Chemother Pharmacol.  2019  83(4):659-671  PubMed ID: 30659304   DOI: 10.1007/s00280-019-03768-8
10222  Yang L, Huang S, Ma H, Wu X, Feng F.  MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer.  Tumour Biol.  2017  39:1010428317692249  PubMed ID: 28347246   DOI: 10.1177/1010428317692249
3727  Yeung Y, Lau DK, Chionh F, Tran H, Tse JWT, Weickhardt AJ, Nikfarjam M, Scott AM, Tebbutt NC, Mariadason JM  K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.  Mol Oncol  2017  11(9):1130-1142  PubMed ID: 28544747   DOI: 10.1002/1878-0261.12078
3735  Saha SK et al  Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.  Cancer Discov  2016  6(7):727-39  PubMed ID: 27231123   DOI: 10.1158/2159-8290.CD-15-1442
3709  Kawamoto T, Ishige K, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J.  Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.  J Gastroenterol  2015  50(4):467-79  PubMed ID: 25112701   DOI: 10.1007/s00535-014-0984-5
13739  Letelier P, García P, Leal P, Álvarez H, Ili C, López J, Castillo J, Brebi P, Roa JC.  miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer  Int J Clin Exp Pathol  2014  7(5):1849-67  PubMed ID: 24966896  
14930  Takahashi N, Aoyama F, Hiyoshi M, Kataoka H, Sawaguchi A.  Establishment and biological characterization of a novel cell line derived from hepatoid adenocarcinoma originated at the ampulla of Vater  Int J Oncol  2014  44(4):1139-45  PubMed ID: 24481592   DOI: 10.3892/ijo.2014.2282
3722  Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.  Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.  Cancer Sci  2012  103(2):252-61  PubMed ID: 22044563   DOI: 10.1111/j.1349-7006.2011.02138.x
7862  Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M.  Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.  J Hepatobiliary Pancreat Sci  2011  18:700-11  PubMed ID: 21451941   DOI: 10.1007/s00534-011-0376-7
3705  Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.  Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.  World J Gastroenterol  2009  15(31):3865-73  PubMed ID: 19701966   DOI: 10.3748/wjg.15.3865
18693  Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S.  Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer  Gastroenterology  2008  135(4):1358-1368  PubMed ID: 18692501   DOI: 10.1053/j.gastro.2008.06.082
5903  Kamoshida S, Suzuki M, Sakurai Y, Ochiai M, Kimura F, Kuwao S, Sakamoto K, Sugimoto Y, Fukushima M, Tsutsumi Y.  Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs.  Oncol Rep  2006  16(4):721-7  PubMed ID: 16969485  
3700  Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y.  Expression of homeodomain protein CDX2 in gallbladder carcinomas.  J Cancer Res Clin Oncol  2005  131(5):271-8  PubMed ID: 15645288   DOI: 10.1007/s00432-004-0658-4
13755  Asakura T, Imai A, Ohkubo-Uraoka N, Kuroda M, Iidaka Y, Uchida K, Shibasaki T, Ohkawa K.  Relationship between expression of drug-resistance factors and drug sensitivity in normal human renal proximal tubular epithelial cells in comparison with renal cell carcinoma  Oncol Rep  2005  14(3):601-7.  PubMed ID: 16077962  


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