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Cell No. : Cell Name
RCB1186 : TGBC14TKB  update : 2021/01/08
CommentJapanese gallbladder tumor passed through a nude mouse. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Todoroki, T. & Ohno, T.
Originator Todoroki, T. & Ohno, T. & Kim, B.
Year of deposit 1995
Another name AkAs
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Tissue gallbladder
Classification cancer
Year of origin 1995
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/1-2 weeks, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
Chromosome mode 58-65(50) : /59(2),60(7),61(20),62(14),63(4),64(1)/
Images
deposit info
lot info
Reference information Reference 2
User's Publication 14


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Reference
2319  Koike N, Todoroki T, Kawamoto T, Yoshida S, Kashiwagi H, Fukao K, Ohno T, Watanabe T  The invasion potentials of human biliary tract carcinoma cell lines: correlation between invasiveness and morphologic characteristics.  Int J Oncol  1998  13:1269-74  PubMed ID: 9824643
2237  Moon,Y., Dahlberg,W. K., Yu,Y., Ohno,T. Todoroki,T., and Little,J. B.   Radiosensitivity of human biliary tract cancer cell lines in vitro  Int J Oncol  1997  10:545-551  PubMed ID: 21533411

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User's Publication
13778  Yamashita T, Kato K, Fujihara S, Iwama H, Morishita A, Yamana H, Kobayashi K, Kamada H, Chiyo T, Kobara H, Tsutsui K, Okano K, Suzuki Y, Masaki T.  Anti-diabetic drug metformin inhibits cell proliferation and tumor growth in gallbladder cancer via G0/G1 cell cycle arrest  Anticancer Drugs  2020  31(3):231-240  PubMed ID: 31815765
3738  Yamashita-Kashima Y, Yoshimura Y, Fujimura T, Shu S, Yanagisawa M, Yorozu K, Furugaki K, Higuchi R, Shoda J, Harada N.  Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.  Cancer Chemother Pharmacol.  2019  83(4):659-671  PubMed ID: 30659304
10222  Yang L, Huang S, Ma H, Wu X, Feng F.  MicroRNA-125b predicts clinical outcome and suppressed tumor proliferation and migration in human gallbladder cancer.  Tumour Biol.  2017  39:1010428317692249  PubMed ID: 28347246
3727  Yeung Y, Lau DK, Chionh F, Tran H, Tse JWT, Weickhardt AJ, Nikfarjam M, Scott AM, Tebbutt NC, Mariadason JM  K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.  Mol Oncol  2017  11(9):1130-1142  PubMed ID: 28544747
3735  Saha SK et al  Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma.  Cancer Discov  2016  6(7):727-39  PubMed ID: 27231123
3709  Kawamoto T, Ishige K, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J.  Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.  J Gastroenterol  2015  50(4):467-79  PubMed ID: 25112701
13739  Letelier P, García P, Leal P, Álvarez H, Ili C, López J, Castillo J, Brebi P, Roa JC.  miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer  Int J Clin Exp Pathol  2014  7(5):1849-67  PubMed ID: 24966896
3722  Ohashi H, Adachi Y, Yamamoto H, Taniguchi H, Nosho K, Suzuki H, Arimura Y, Imai K, Carbone DP, Shinomura Y.  Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers.  Cancer Sci  2012  103(2):252-61  PubMed ID: 22044563
7862  Sato J, Kimura T, Saito T, Anazawa T, Kenjo A, Sato Y, Tsuchiya T, Gotoh M.  Gene expression analysis for predicting gemcitabine resistance in human cholangiocarcinoma.  J Hepatobiliary Pancreat Sci  2011  18:700-11  PubMed ID: 21451941
3705  Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y.  Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.  World J Gastroenterol  2009  15(31):3865-73  PubMed ID: 19701966
5903  Kamoshida S, Suzuki M, Sakurai Y, Ochiai M, Kimura F, Kuwao S, Sakamoto K, Sugimoto Y, Fukushima M, Tsutsumi Y.  Expression of chemoresistance-related proteins in alpha-fetoprotein-producing adenocarcinoma of the digestive organs.  Oncol Rep  2006  16(4):721-7 
3700  Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y.  Expression of homeodomain protein CDX2 in gallbladder carcinomas.  J Cancer Res Clin Oncol  2005  131(5):271-8  PubMed ID: 15645288
13755  Asakura T, Imai A, Ohkubo-Uraoka N, Kuroda M, Iidaka Y, Uchida K, Shibasaki T, Ohkawa K.  Relationship between expression of drug-resistance factors and drug sensitivity in normal human renal proximal tubular epithelial cells in comparison with renal cell carcinoma  Oncol Rep  2005  14(3):601-7.  PubMed ID: 16077962
2673  Ghosh, Mila, Koike, Naoto, Yanagimoto, Go, Tsunoda, Shin-Ichi, Kaul, Sunil, Hirano, Takashi, Emura, Fabian, Kashiwagi, Hironobu, Kawamoto, Toru, Ohkohchi, Nobuhiro, Saijo, Kaoru, Ohno, Tadao, Miwa, Masanao, Todoroki, Takeshi  Establishment and characterization of unique human gallbladder cancer cell lines.  Int J Oncol  2004  24:1189-96  PubMed ID: 15067341



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