細胞番号 : 細胞名
RCB1184 : Lu-165
update : 2024/10/02
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| 細胞特性(Comment:英) | Producing high level of anti-diuretic hormone. Application consideration |
| 細胞特性(日) | 大量のanti-diuretic hormoneを産生する肺小細胞癌。培養開始にあたっての注意 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Terasaki, Takeo
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| 樹立者 |
Terasaki, Takeo
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| 寄託日 |
1995
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| 動物種 |
_human
< Mammals
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| 属名 |
Homo
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| 種名 |
sapiens
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| 人種 |
Japanese
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| 性別 |
Male
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| 齢 |
50 years
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| 採取組織 |
lung, lymph node meta
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| 病名 |
small cell carcinoma
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| 転移 |
Yes
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| 転移巣 |
lymph node
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| 細胞分類 |
cancer
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| 初代培養日 |
1991
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細胞寿命 |
infinite
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| 細胞形態 |
other
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| Cellosaurus(Expasy) |
CVCL_1391
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Suspension cells
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| 培養方法 |
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浮遊細胞の培養に関する一般的な注意(Japanese)
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| 培地 |
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RPMI1640 + 10% FBS
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| 抗生物質 |
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Free
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|
継代方法 |
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dilution
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継代密度 |
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1 : 4 split
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| 継代・培地交換頻度 |
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Subculture : once/week, Medium Renewal : 2 times/week
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| 培養最適温度 |
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37
℃
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| 二酸化炭素濃度 |
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5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ/アコレプラズマ |
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(-)
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| ウィルス（HIV) |
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(-)
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| アイソザイム検査 |
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LD, NP
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| 染色体検査 |
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37-107(50) : /39(1),40(6),41(17),42(13),43(6)/
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| 個体識別検査 |
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OK
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| 画像情報 |
寄託時情報 | ロット情報 |
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| 文献情報 |
Reference(英) |
5件
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| Reference(日) |
0件
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| 利用者成果(英) |
10件
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| 利用者成果(日) |
0件
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| Reference(英) |
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3152
Coulson, J M, Stanley J, Woll, P J
Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer.
Br J Cancer
1999
80:1935-44
PubMed ID: 10471042
DOI: 10.1038/sj.bjc.6690623
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3154
Coulson, J M, Fiskerstrand, C E, Woll, P J, Quinn, J P
Arginine vasopressin promoter regulation is mediated by a neuron-restrictive silencer element in small cell lung cancer.
Cancer Res
1999
59:5123-7
PubMed ID: 10537286
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3153
Coulson, J M, Fiskerstrand, C E, Woll, P J, Quinn, J P
E-box motifs within the human vasopressin gene promoter contribute to a major enhancer in small-cell lung cancer
Biochem J
1999
344:961-970
PubMed ID: 10585887
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3150
Tanaka K, Terasaki T
Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines
Oncogene
1997
88:176-183
PubMed ID: 9119746
DOI: 10.1111/j.1349-7006.1997.tb00363.x
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|
1974
Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K
Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.
Jpn J Cancer Res (--> Cancer Sci)
1994
85:718-22
PubMed ID: 8071114
DOI: 10.1111/j.1349-7006.1994.tb02420.x
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| 利用者成果(英) |
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21514
Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.
Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.
Nat Commun
2023
14(1):8095
PubMed ID: 38092728
DOI: 10.1038/s41467-023-43630-3
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17037
Romero OA, Vilarrubi A, Alburquerque-Bejar JJ, Gomez A, Andrades A, Trastulli D, Pros E, Setien F, Verdura S, Farré L, Martín-Tejera JF, Llabata P, Oaknin A, Saigi M, Piulats JM, Matias-Guiu X, Medina PP, Vidal A, Villanueva A, Sanchez-Cespedes M.
SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
Nat Commun
2021
12(1):4319
PubMed ID: 34262032
DOI: 10.1038/s41467-021-24618-3
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9502
Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.
PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.
Cancer Cell
2018
33:355-367.e7
PubMed ID: 29533781
DOI: 10.1016/j.ccell.2018.02.004
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12940
Ohta T, Mita M, Hishinuma S, Ishii-Nozawa R, Takahashi K, Shoji M.
Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165
Front Endocrinol (Lausanne)
2017
8:94
PubMed ID: 28503166
DOI: 10.3389/fendo.2017.00094
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9873
Kato F, Fiorentino FP, Alibés A, Perucho M, Sánchez-Céspedes M, Kohno T, Yokota J.
MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.
Oncotarget
2016
7:77378-77388
PubMed ID: 27764802
DOI: 10.18632/oncotarget.12671
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6410
Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
PubMed ID: 19624309
DOI: 10.1111/j.1749-0774.2009.00071.x
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19312
Yabuta N, Onda H, Watanabe M, Yoshioka N, Nagamori I, Funatsu T, Toji S, Tamai K, Nojima H.
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest
Nucleic Acids Res
2006
34(17):4878-92.
PubMed ID: 16973895
DOI: 10.1093/nar/gkl651
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16489
Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S.
Proteomic signatures for histological types of lung cancer
Proteomics
2005
5(11):2939-48
PubMed ID: 15996008
DOI: 10.1002/pmic.200401166
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2929
Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y
Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles
Lancet
2004
63:775-781
PubMed ID: 15016488
DOI: 10.1016/S0140-6736(04)15693-6
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3338
Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo
Proteomic signature of human cancer cells.
Proteomics
2004
4:2776-88
PubMed ID: 15352251
DOI: 10.1002/pmic.200300795
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