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Cell No. : Cell Name
RCB1184 : Lu-165  update : 2025/03/26
CommentProducing high level of anti-diuretic hormone. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Terasaki, Takeo
Originator Terasaki, Takeo
Year of deposit 1995
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 50 years
Tissue lung, lymph node meta
Disease name small cell carcinoma
Metastatic ability Yes
Metastatic tissue lymph node
Classification cancer
Year of origin 1991
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_1391
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method General Guidelines for Culturing Suspension Cells, 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 37-107(50) : /39(1),40(6),41(17),42(13),43(6)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 5
User's Publication 13


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Reference
3152  Coulson, J M, Stanley J, Woll, P J  Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer.  Br J Cancer  1999  80:1935-44  PubMed ID: 10471042   DOI: 10.1038/sj.bjc.6690623
3154  Coulson, J M, Fiskerstrand, C E, Woll, P J, Quinn, J P  Arginine vasopressin promoter regulation is mediated by a neuron-restrictive silencer element in small cell lung cancer.  Cancer Res  1999  59:5123-7  PubMed ID: 10537286  
3153  Coulson, J M, Fiskerstrand, C E, Woll, P J, Quinn, J P  E-box motifs within the human vasopressin gene promoter contribute to a major enhancer in small-cell lung cancer  Biochem J  1999  344:961-970  PubMed ID: 10585887  
3150  Tanaka K, Terasaki T  Development and elongation of neurite-like outgrowth on small cell lung cancer cell lines  Oncogene  1997  88:176-183  PubMed ID: 9119746   DOI: 10.1111/j.1349-7006.1997.tb00363.x
1974  Terasaki T, Matsuno Y, Shimosato Y, Yamaguchi K, Ichinose H, Nagatsu T, Kato K  Establishment of a human small cell lung cancer cell line producing a large amount of anti-diuretic hormone.  Jpn J Cancer Res (--> Cancer Sci)  1994  85:718-22  PubMed ID: 8071114   DOI: 10.1111/j.1349-7006.1994.tb02420.x

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User's Publication
22633  Watanabe H, Inoue Y, Tsuchiya K, Asada K, Suzuki M, Ogawa H, Tanahashi M, Watanabe T, Matsuura S, Yasuda K, Ohnishi I, Imokawa S, Yasui H, Karayama M, Suzuki Y, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Funai K, Shinmura K, Sugimura H, Inui N, Suda T.  Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells.  NPJ Precis Oncol  2025  9(1):74  PubMed ID: 40082639   DOI: 10.1038/s41698-025-00860-6
22524  Kasai F, Fukushima M, Miyagi Y, Nakamura Y.  Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan  Hum Cell  2024  37(4):944-950  PubMed ID: 38639832   DOI: 10.1007/s13577-024-01055-0
21514  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.  Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.  Nat Commun  2023  14(1):8095  PubMed ID: 38092728   DOI: 10.1038/s41467-023-43630-3
17037  Romero OA, Vilarrubi A, Alburquerque-Bejar JJ, Gomez A, Andrades A, Trastulli D, Pros E, Setien F, Verdura S, Farré L, Martín-Tejera JF, Llabata P, Oaknin A, Saigi M, Piulats JM, Matias-Guiu X, Medina PP, Vidal A, Villanueva A, Sanchez-Cespedes M.  SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade  Nat Commun  2021  12(1):4319  PubMed ID: 34262032   DOI: 10.1038/s41467-021-24618-3
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781   DOI: 10.1016/j.ccell.2018.02.004
12940  Ohta T, Mita M, Hishinuma S, Ishii-Nozawa R, Takahashi K, Shoji M.  Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165  Front Endocrinol (Lausanne)  2017  8:94  PubMed ID: 28503166   DOI: 10.3389/fendo.2017.00094
9873  Kato F, Fiorentino FP, Alibés A, Perucho M, Sánchez-Céspedes M, Kohno T, Yokota J.  MYCL is a target of a BET bromodomain inhibitor, JQ1, on growth suppression efficacy in small cell lung cancer cells.  Oncotarget  2016  7:77378-77388  PubMed ID: 27764802   DOI: 10.18632/oncotarget.12671
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
19312  Yabuta N, Onda H, Watanabe M, Yoshioka N, Nagamori I, Funatsu T, Toji S, Tamai K, Nojima H.  Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest  Nucleic Acids Res  2006  34(17):4878-92.  PubMed ID: 16973895   DOI: 10.1093/nar/gkl651
16489  Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S.  Proteomic signatures for histological types of lung cancer  Proteomics  2005  5(11):2939-48  PubMed ID: 15996008   DOI: 10.1002/pmic.200401166
2929  Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y  Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles  Lancet  2004  63:775-781  PubMed ID: 15016488   DOI: 10.1016/S0140-6736(04)15693-6
3338  Seike, Masahiro, Kondo, Tadashi, Fujii, Kazuyasu, Yamada, Tesshi, Gemma, Akihiko, Kudoh, Shoji, Hirohashi, Setsuo  Proteomic signature of human cancer cells.  Proteomics  2004  4:2776-88  PubMed ID: 15352251   DOI: 10.1002/pmic.200300795
2002  Fukunaga Y, Bandoh S, Fujita J, Yang Y, Ueda Y, Hojo S, Dohmoto K, Tojo Y, Takahara J, Ishida T.  Expression of cytokeratin 8 in lung cancer cell lines and measurement of serum cytokeratin 8 in lung cancer patients  Lung Cancer   2002  38(1):31-8  PubMed ID: 12367790   DOI: 10.1016/s0169-5002(02)00109-5


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