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Cell No. : Cell Name
RCB1165 : YAC-1  update : 2025/01/16
CommentNatural killer cell-sensitive mouse lymphoma.Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 96 prior to order.
Comment from the depositor
Terms and conditions1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 96 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor DSMZ
Year of deposit 1995
Animal _mouse < Mammals
Tissue lymphoma
Disease name leukemia
Classification cancer
History DSMZ (ACC96)
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_2244
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method General Guidelines for Culturing Suspension Cells, 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : once/3-4 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 4
User's Publication 31


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Reference
4942  Tsai L, Ohlén C, Ljunggren HG, Kärre K, Hansson M, Kiessling R.  Effect of IFN-gamma treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine-activated killer (LAK) cell lysis in vitro; association with H-2 expression on the target cells.  Int J Cancer  1989  44(4):669-74  PubMed ID: 2507452   DOI: 10.1002/ijc.2910440419
4941  Klein GO, Grönberg A, Kiessling R, Klein G.  Decreased sensitivity of immunoselected and NK-selected YAC lymphoma sublines to hybrid resistance in vivo.  Eur J Cancer Clin Oncol  1982  18(2):191-8  PubMed ID: 6807680   DOI: 10.1016/0277-5379(82)90063-3
982  Kiessling R, Klein E, Wigzell H.  "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype.  Eur J Immunol  1975  5(2):112-7  PubMed ID: 1234049   DOI: 10.1002/eji.1830050208
4940  Lamon EW, Gatti RA, Kiessling R, Fenyö EM.  Comparison of the allospecific and viral-specific immune responses to irradiated versus formaldehyde-fixed allogeneic Moloney lymphoma cells in CBA mice.  Cancer Res  1975  35(4):962-9  PubMed ID: 1090367  

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User's Publication
19508  Watanabe S, Takagi A, Yuba E, Kojima C, Dei N, Matsumoto A, Tanikawa J, Kawamura T, De Silva NH, Izawa T, Akazawa T, Kanegi R, Hatoya S, Inaba T, Sugiura K.  In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitum  FASEB J  2023  37(11):e23228  PubMed ID: 37815518   DOI: 10.1096/fj.202202036R
21030  Hattori K, Takagi H, Ogata Y, Yamada T, Horiba H, Fukata K, Sakaida T, Yashiro Y, Hasegawa S, Tanaka H.  Immunostimulatory effects of a subcritical water extract of Ganoderma.  Biomed Rep  2023    PubMed ID: 36544853   DOI: 10.3892/br.2022.1583
18101  Sugimoto C, Murakami Y, Ishii E, Fujita H, Wakao H.  Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity  Elife  2022  11:e70848  PubMed ID: 35379387   DOI: 10.7554/eLife.70848
20556  Watanabe S, Yuba E, Akazawa T, Wijewardana V, Kakihara Y, Azuma A, Hagimori K, Kanegi R, Hatoya S, Inoue N, Inaba T, Sugiura K.  Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand.  Vaccine  2022    PubMed ID: 35131134   DOI: 10.1016/j.vaccine.2022.01.048
6934  Baba K, Kuwada S, Nakao A, Li X, Okuda N, Nishida A, Mitsuda S, Fukuoka N, Kakeya H, Kataoka T.  Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.  Histochem Cell Biol  2020    PubMed ID: 31907597   DOI: 10.1007/s00418-019-01842-z
13949  Wijesekera DPH, Yuba E, De Silva NH, Watanabe SI, Tsukamoto M, Ichida C, Izawa T, Itoh K, Kanegi R, Hatoya S, Yamate J, Inaba T, Sugiura K.  Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy  FASEB Bioadv  2020  2(1):5-17  PubMed ID: 32123853   DOI: 10.1096/fba.2019-00052
4374  Une S, Nonaka K, Akiyama J.  Lectin Isolated from Japanese Red Sword Beans (Canavalia gladiata) as a Potential Cancer Chemopreventive Agent.  J. Food Sci.  2018  83(3):837-843  PubMed ID: 29437230   DOI: 10.1111/1750-3841.14057
14549  Tsuji R, Ikado K, Fujiwara D.  Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production  Int J Mol Sci  2017  19(1):64  PubMed ID: 29278400   DOI: 10.3390/ijms19010064
9804  Kiniwa T, Enomoto Y, Terazawa N, Omi A, Miyata N, Ishiwata K, Miyajima A.  NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:10139-44  PubMed ID: 27551096   DOI: 10.1073/pnas.1600112113
12986  Romero-Pérez GA, Egashira M, Harada Y, Tsuruta T, Oda Y, Ueda F, Tsukahara T, Tsukamoto Y, Inoue R.  Orally Administered Salacia reticulata Extract Reduces H1N1 Influenza Clinical Symptoms in Murine Lung Tissues Putatively Due to Enhanced Natural Killer Cell Activity  Front Immunol  2016  7:115  PubMed ID: 27066007   DOI: 10.3389/fimmu.2016.00115
15248  Kawahara T, Takahashi T, Oishi K, Tanaka H, Masuda M, Takahashi S, Takano M, Kawakami T, Fukushima K, Kanazawa H, Suzuki T.  Consecutive oral administration of Bifidobacterium longum MM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model  Microbiol Immunol  2015  59(1):1-12  PubMed ID: 25400245   DOI: 10.1111/1348-0421.12210
17089  Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A.  Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15  Eur J Immunol  2014  44(9):2638-47  PubMed ID: 24995967   DOI: 10.1002/eji.201444570
17114  Murata K, Abe Y, Futamura-Masudaa M, Uwaya A, Isami F, Matsuda H.  Activation of cell-mediated immunity by Morinda citrifolia fruit extract and its constituents  Nat Prod Commun  2014  9(4):445-50  PubMed ID: 24868850  
9095  N Meshii, G Takahashi, S Okunaga, M Hamada, S Iwai, A Takasu, Y Ogawa, Y Yura  Enhancement of Systemic Tumor Immunity for Squamous Cell Carcinoma Cells by an Oncolytic Herpes Simplex Virus  Cancer Gene Ther  2013  20 (9), 493-8  PubMed ID: 23887644   DOI: 10.1038/cgt.2013.45
15341  Kovacs-Nolan J, Kanatani H, Nakamura A, Ibuki M, Mine Y.  β-1,4-mannobiose stimulates innate immune responses and induces TLR4-dependent activation of mouse macrophages but reduces severity of inflammation during endotoxemia in mice  J Nutr  2013  143(3):384-91  PubMed ID: 23343679   DOI: 10.3945/jn.112.167866
18670  Yoshida N, Ino K, Ishida Y, Kajiyama H, Yamamoto E, Shibata K, Terauchi M, Nawa A, Akimoto H, Takikawa O, Isobe K, Kikkawa F.  Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model  Clin Cancer Res  2008  14(22):7251-9  PubMed ID: 19010841   DOI: 10.1158/1078-0432.CCR-08-0991
18759  Kimura Y, Sumiyoshi M, Baba K.  Anti-tumor actions of major component 3'-O-acetylhamaudol of Angelica japonica roots through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation  Cancer Lett  2008  265(1):84-97  PubMed ID: 18358599   DOI: 10.1016/j.canlet.2008.02.009
19397  Hisatake Hayase, Yasuhiro Ohshima, Mareyuki Takahashi, Shuji Kojima  The enhancement of Th1 immunity and the suppression of tumour growth by low-dose γ-radiation  International Journal of Low Radiation  2008  5:275    DOI: 10.1504/ijlr.2008.020977
18763  Kimura Y, Sumiyoshi M, Suzuki T, Suzuki T, Sakanaka M.  Effects of water-soluble low-molecular-weight beta-1, 3-D-glucan (branch beta-1, 6) isolated from Aureobasidium pullulans 1A1 strain black yeast on restraint stress in mice  J Pharm Pharmacol  2007  59(8):1137-44  PubMed ID: 17725857   DOI: 10.1211/jpp.59.8.0012
3329  Iinuma, Hisae, Okinaga, Kota, Fukushima, Ryoji, Inaba, Tsuyoshi, Iwasaki, Kota, Okinaga, Akira, Takahashi, Ichiro, Kaneko, Michio  Superior protective and therapeutic effects of IL-12 and IL-18 gene-transduced dendritic neuroblastoma fusion cells on liver metastasis of murine neuroblastoma.  J Immunol  2006  176:3461-9  PubMed ID: 16517714   DOI: 10.4049/jimmunol.176.6.3461
3331  Ebata, Kazumi, Shimizu, Yukihiro, Nakayama, Yasuhiro, Minemura, Masami, Murakami, Jun, Kato, Tsutomu, Yasumura, Satoshi, Takahara, Terumi, Sugiyama, Toshiro, Saito, Shigeru  Immature NK cells suppress dendritic cell functions during the development of leukemia in a mouse model.  J Immunol  2006  176:4113-24  PubMed ID: 16547247   DOI: 10.4049/jimmunol.176.7.4113
3169  Koga, Tomoaki, Harada, Hideki, Shi, Tea Seow, Okada, Seiji, Suico, Mary Ann, Shuto, Tsuyoshi, Kai, Hirofumi  Hyperthermia suppresses the cytotoxicity of NK cells via down-regulation of perforin/granzyme B expression.  Biochem Biophys Res Commun  2005  337:1319-23  PubMed ID: 16236268   DOI: 10.1016/j.bbrc.2005.09.184
18760  Kimura Y, Sumiyoshi M.  Effects of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in forced swimming stressed mice  J Ethnopharmacol  2004  95(2-3):447-53  PubMed ID: 15507373   DOI: 10.1016/j.jep.2004.08.027
6153  Misawa E, Sakurai T, Yamada M, Tamura Y, Motoyoshi K.  Administration of macrophage colony-stimulating factor mobilized both CD11b+CD11c+ cells and NK1.1+ cells into peripheral blood.  Int Immunopharmacol  2004  4(6):791-803  PubMed ID: 15135320   DOI: 10.1016/j.intimp.2004.03.004
17307  Peng Baogang, Liang Lijian, Liu Shuqin, Huang Jiefu, He Qiang, Lu Mingde, Leong Kam W, Ohno Tadao  Fixed-tumor vaccine: A practical formulation with cytokine-microspheres for protective and therapeutic antitumor immunity  The Chinese-German Journal of Clinical Oncology  2003  2:196-202    DOI: 10.1007/bf02835455
2637  Kasahara M, Watanabe Y, Sumasu M, Nagata T  A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.  Proc Natl Acad Sci U S A  2002  99:13687-92  PubMed ID: 12370446   DOI: 10.1073/pnas.212375299
4711  Tanji H, Yahata H, Hayamizu K, Shinozaki K, Okimoto T, Sakaguchi T, Asahara T.  Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein.  Cancer Gene Ther  2002  9(8):655-64  PubMed ID: 12136426   DOI: 10.1038/sj.cgt.7700483
16911  Akasaki Y, Kikuchi T, Homma S, Abe T, Kofe D, Ohno T.  Antitumor effect of immunizations with fusions of dendritic and glioma cells in a mouse brain tumor model  J Immunother  2001  24(2):106-13.  PubMed ID: 11265767  
18801  Joki T, Kikuchi T, Akasaki Y, Saitoh S, Abe T, Ohno T.  Induction of effective antitumor immunity in a mouse brain tumor model using B7-1 (CD80) and intercellular adhesive molecule 1 (ICAM-1; CD54) transfection and recombinant interleukin 12  Int J Cancer  1999  82(5):714-20  PubMed ID: 10417770   DOI: 10.1002/(sici)1097-0215(19990827)82:5<714::aid-ijc15>3.0.co;2-q
1264  Sakurai T, Wakimoto N, Yamada M, Shimamura S, Motoyoshi K.  Effect of macrophage colony-stimulating factor on mouse NK 1.1+ cell activity in vivo  Int J Immunopharmacol  1998  20(8):401-13  PubMed ID: 9778101   DOI: 10.1016/s0192-0561(98)00040-x
17885  Takahashi JA, Fukumoto M, Kozai Y, Ito N, Oda Y, Kikuchi H, Hatanaka M.  Induction of cytotoxic cell activities by a novel cyclic disulfide compound, SA3443 in vivo  Immunopharmacol Immunotoxicol  1991  13(1-2):121-33  PubMed ID: 1770215   DOI: 10.3109/08923979109019695


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