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Cell No. : Cell Name
RCB1154 : KGN  update : 2022/09/01
CommentHuman cell line derived from ovarian granulosa cell tumor. Aromatase activity is increased by stimulation of FSH and hMG.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Nishi, Y. & Nawata, H.
Originator Nishi, Yoshihiro & Nawata, Hajime
Year of deposit 1995
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 69 years
Tissue ovary, peritoneum
Disease name granulosa cell tumor
Classification cancer
Year of origin 1993
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_0375
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM/HamF12 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 43-46(50) : 43(1),44(1),45(45),46(3)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 10
User's Publication 120


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Reference
4938  Bao B, Jiang J, Yanase T, Nishi Y, Morgan JR.  Connexon-mediated cell adhesion drives microtissue self-assembly.  FASEB J  2011  25(1):255-64  PubMed ID: 20876208   DOI: 10.1096/fj.10-155291
4936  Kwintkiewicz J, Nishi Y, Yanase T, Giudice LC.  Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells.  Environ Health Perspect  2010  118(3):400-6  PubMed ID: 20064783   DOI: 10.1289/ehp.0901161
4935  Jääskeläinen M, Kyrönlahti A, Anttonen M, Nishi Y, Yanase T, Secchiero P, Zauli G, Tapanainen JS, Heikinheimo M, Vaskivuo TE.  TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.  Differentiation  2009  77(4):369-76  PubMed ID: 19281785   DOI: 10.1016/j.diff.2008.12.001
4934  Mottershead DG1, Pulkki MM, Muggalla P, Pasternack A, Tolonen M, Myllymaa S, Korchynskyi O, Nishi Y, Yanase T, Lun S, Juengel JL, Laitinen M, Ritvos O.  Characterization of recombinant human growth differentiation factor-9 signaling in ovarian granulosa cells.  Mol Cell Endocrinol  2008  283(1-2):58-67  PubMed ID: 18162287   DOI: 10.1016/j.mce.2007.11.007
4933  Wu Y, Ghosh S, Nishi Y, Yanase T, Nawata H, Hu Y.  The orphan nuclear receptors NURR1 and NGFI-B modulate aromatase gene expression in ovarian granulosa cells: a possible mechanism for repression of aromatase expression upon luteinizing hormone surge.  Endocrinology  2005  146(1):237-46  PubMed ID: 15486232   DOI: 10.1210/en.2004-0889
4932  Chu S, Nishi Y, Yanase T, Nawata H, Fuller PJ.  Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells.  Mol Endocrinol  2004  18(8):1919-28  PubMed ID: 15155785   DOI: 10.1210/me.2004-0021
4930  Fujii A, Harada T, Yamauchi N, Iwabe T, Nishi Y, Yanase T, Nawata H, Terakawa N.  Interleukin-8 gene and protein expression are up-regulated by interleukin-1beta in normal human ovarian cells and a granulosa tumor cell line.  Fertil Steril  2003  79(1):151-7  PubMed ID: 12524080   DOI: 10.1016/s0015-0282(02)04408-4
4931  Mukasa C, Nomura M, Tanaka T, Tanaka K, Nishi Y, Okabe T, Goto K, Yanase T, Nawata H.  Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.  Endocrinology  2003  144(4):1603-11  PubMed ID: 12639945   DOI: 10.1210/en.2002-220978
4928  Nishi Y, Yanase T, Mu Y, Oba K, Ichino I, Saito M, Nomura M, Mukasa C, Okabe T, Goto K, Takayanagi R, Kashimura Y, Haji M, Nawata H.  Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.  Endocrinology  2001  42(1):437-45  PubMed ID: 11145608   DOI: 10.1210/endo.142.1.7862
4929  Saitoh M, Yanase T, Morinaga H, Tanabe M, Mu YM, Nishi Y, Nomura M, Okabe T, Goto K, Takayanagi R, Nawata H.  Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN.  Biochem Biophys Res Commun  2001  289(1):198-204  PubMed ID: 11708799   DOI: 10.1006/bbrc.2001.5952

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User's Publication
20340  Niu Q, Shi J, Gao Q, Fu J.  WNT5A Enhances LH-Mediated Expression of HAS2 in Granulosa Cells.  Reprod Sci  2022    PubMed ID: 34542891   DOI: 10.1007/s43032-021-00736-7
20535  Zhang L, Mao B, Zhao X, Yuan Y, Wang W, Lin S.  Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure.  Bioengineered  2022  13(2):2173-2180  PubMed ID: 35034562   DOI: 10.1080/21655979.2021.2023802
20543  Mi X, Jiao W, Yang Y, Qin Y, Chen ZJ, Zhao S.  HGF Secreted by Mesenchymal Stromal Cells Promotes Primordial Follicle Activation by Increasing the Activity of the PI3K-AKT Signaling Pathway.  Stem Cell Rev Rep  2022    PubMed ID: 35089464   DOI: 10.1007/s12015-022-10335-x
16239  Cluzet V, Devillers MM, Petit F, Pierre A, Giton F, Airaud E, L'Hôte D, Leary A, Genestie C, Treilleux I, Mayeur A, Katzenellenbogen JA, Kim SH, Cohen-Tannoudji J, Chauvin S, Guigon CJ.  Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα-dependent mechanism  J Pathol  2022  256(3):335-348  PubMed ID: 34860414   DOI: 10.1002/path.5843
20528  Shao T, Ke H, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y, Zhao S.  Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.  Autophagy  2022  1-15  PubMed ID: 35025698   DOI: 10.1080/15548627.2021.2005415
20651  Asma A, Marc-André S.  Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN).  Int J Mol Sci  2022  23(6)  PubMed ID: 35328408   DOI: 10.3390/ijms23062988
16505  Nishigaki A, Tsubokura H, Ishida M, Hashimoto Y, Yoshida A, Hisamatsu Y, Tsuzuki-Nakao T, Murata H, Okada H.  NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary  Reprod Med Biol  2022  21(1):e12437  PubMed ID: 35386369   DOI: 10.1002/rmb2.12437
16767  Chen H, Chen Q, Zhu Y, Yuan K, Li H, Zhang B, Jia Z, Zhou H, Fan M, Qiu Y, Zhuang Q, Lei Z, Li M, Huang W, Liang L, Yan Q, Wang C.  MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development  Front Genet  2022  13:736988  PubMed ID: 35309143   DOI: 10.3389/fgene.2022.736988
20777  Panagiotou EM, Draskau MK, Li T, Hirschberg AL, Svingen T, Damdimopoulou P.  AOP Key Event Relationship Report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles.  Reprod Toxicol  2022    PubMed ID: 35868514   DOI: 10.1016/j.reprotox.2022.07.004
17003  Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J.  Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN  Arch Biochem Biophys  2022  715:109094  PubMed ID: 34813774   DOI: 10.1016/j.abb.2021.109094
17013  Zhang QY, Li X, Zhou XY, Li Y, Zhang J, Zhang XF, Liu YD, Chen YX, Wu XM, Ma LZ, Chen X, Chen SL.  Study of differential proteomics in granulosa cells of premature ovarian insufficiency (POI) and the roles and mechanism of RAC1 in granulosa cells  Mol Cell Endocrinol  2022  555:111719  PubMed ID: 35850487   DOI: 10.1016/j.mce.2022.111719
17015  Kang W, Ishida E, Amita M, Tatsumi K, Yonezawa H, Yohtsu M, Katano D, Onozawa K, Kaneko E, Iwasaki W, Naito N, Yamada M, Kawano N, Miyado M, Sato B, Saito H, Saito T, Miyado K.  Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility  Nutrients  2022  14(10):2156  PubMed ID: 35631296   DOI: 10.3390/nu14102156
20854  Wang W, Hao J, Shi Y.  IL23 suppresses proliferation and promotes apoptosis of human granulosa-like tumor cell line KGN by targeting the androgen receptor signal pathway.  Gynecol Endocrinol  2022  1-6  PubMed ID: 36123810   DOI: 10.1080/09513590.2022.2123914
20902  Arjoune A, Sirard MA.  The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors.  Sci Rep  2022  12(1):17539  PubMed ID: 36266374   DOI: 10.1038/s41598-022-21162-y
13389  Li D, Wang X, Dang Y, Zhang X, Zhao S, Lu G, Chan WY, Leung PCK, Qin Y.  lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.  Mol Ther Nucleic Acids  2021    PubMed ID: 33335798   DOI: 10.1016/j.omtn.2020.10.041
20143  Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y.  LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.  Cell Death Discov  2021  7(1):107  PubMed ID: 33993190   DOI: 10.1038/s41420-021-00493-1
20306  Jiao X, Zhang X, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ, Chen W, Qin Y.  Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells.  Clin Transl Med  2021  11(6):e448  PubMed ID: 34185428   DOI: 10.1002/ctm2.448
15496  Kotomura N, Harada N, Shimono Y, Ishihara S.  Transcriptional regulation of CYP1 9 by cohesin-mediated chromosome tethering in human granulosa cells  Biochem Biophys Rep  2021  27:101086  PubMed ID: 34368471   DOI: 10.1016/j.bbrep.2021.101086
15497  Xu X, Song X, Xu X, Zheng Y, Xu L, Shen L.  Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy  Aging (Albany NY)   2021  13(8):11774-11785  PubMed ID: 33883304   DOI: 10.18632/aging.202872
15513  Li Y, Liu YD, Zhou XY, Zhang J, Wu XM, Yang YZ, Chen YX, Zhang XF, Li X, Ma LZ, Wang Z, Chen SL.  Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism  Mol Cell Endocrinol  2021  535:111392  PubMed ID: 34246727   DOI: 10.1016/j.mce.2021.111392
20383  Xu L, Xiong F, Bai Y, Xiao J, Zhang Y, Chen J, Li Q.  Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome.  Reprod Biol Endocrinol  2021  19(1):167  PubMed ID: 34740363   DOI: 10.1186/s12958-021-00839-5
20386  Zheng C, Liu S, Qin Z, Zhang X, Song Y.  LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis.  J Ovarian Res  2021  14(1):151  PubMed ID: 34740384   DOI: 10.1186/s13048-021-00905-x
20395  Li D, Xu W, Wang X, Dang Y, Xu L, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y.  lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1.  Mol Ther Nucleic Acids  2021  26:1092-1106  PubMed ID: 34786213   DOI: 10.1016/j.omtn.2021.10.015
20429  Zhou XY, Zhang J, Li Y, Chen YX, Wu XM, Li X, Zhang XF, Ma LZ, Yang YZ, Zheng KM, Liu YD, Wang Z, Chen SL.  Advanced Oxidation Protein Products Induce G1/G0-Phase Arrest in Ovarian Granulosa Cells via the ROS-JNK/p38 MAPK-p21 Pathway in Premature Ovarian Insufficiency.  Oxid Med Cell Longev  2021  2021:6634718  PubMed ID: 34367464   DOI: 10.1155/2021/6634718
15886  Wu YX, Lin YS, Li SC, Yao X, Cheng M, Zhu L, Liu HY.  microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor  Reprod Biol Endocrinol  2021  19(1):170  PubMed ID: 34814928   DOI: 10.1186/s12958-021-00850-w
20485  Tremblay PG, Fortin C, Sirard MA.  Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin.  J Ovarian Res  2021  14(1):178  PubMed ID: 34930403   DOI: 10.1186/s13048-021-00934-6
20719  Schmid N, Dietrich KG, Forne I, Burges A, Szymanska M, Meidan R, Mayr D, Mayerhofer A.  Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.  Int J Mol Sci  2021  22(4)  PubMed ID: 33669567   DOI: 10.3390/ijms22042047
16858  J Gogola-Mruk, K Krawczyk, W Marynowicz, A Ptak  210 Visfatin increases invasion in human adult granulosa tumor cell line by stimulation of glucose metabolism reprogramming  Ovarian cancer  2021      DOI: 10.1136/ijgc-2021-esgo.357
16859  I Rodolakis, A Prodromidou, M Sotiropoulou, M Liontos, D Haidopoulos, A Bamias, D Loutradis, N Thomakos, A Rodolakis  217 The impact of chemotherapy response score and lymphocytic infiltration in patients with ovarian cancer treated with neoadjuvant chemotherapy  Ovarian cancer  2021      DOI: 10.1136/ijgc-2021-esgo.358
16872  G Cass, R Lewes, J Pawade, C Newton  219 Skin capillary density as a novel biomarker of cytotoxic and bevacizumab treatment in ovarian cancer: a prospective clinical trial  Ovarian cancer  2021      DOI: 10.1136/ijgc-2021-esgo.359
16891  Liu H, Jin H, Kim G, Bae J.  A low dose of bisphenol A stimulates estradiol production by regulating β-catenin-FOXL2-CYP19A1 pathway in human ovarian granulosa cells  Biochem Biophys Res Commun  2021  583:192-198  PubMed ID: 34749236   DOI: 10.1016/j.bbrc.2021.10.070
17006  Crosley P, Farkkila A, Jenner AL, Burlot C, Cardinal O, Potts KG, Agopsowicz K, Pihlajoki M, Heikinheimo M, Craig M, Fu Y, Hitt MM.  Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro  Int J Mol Sci  2021  22(9):4699  PubMed ID: 33946730   DOI: 10.3390/ijms22094699
17024  Qin L, Sitticharoon C, Petyim S, Keadkraichaiwat I, Sririwichitchai R, Maikeaw P, Churintaraphan M, Sripong C.  Roles of kisspeptin in IVF/ICSI-treated infertile women and in human granulosa cells  Exp Biol Med (Maywood)  2021  246(8):996-1010  PubMed ID: 33327782   DOI: 10.1177/1535370220981006
11980  Gogola J, Hoffmann M, Nimpsz S, Ptak A.  Disruption of 17β-estradiol secretion by persistent organic pollutants present in human follicular fluid is dependent on the potential of ovarian granulosa tumor cell lines to metabolize estrogen.  Mol. Cell. Endocrinol.  2020    PubMed ID: 31891770   DOI: 10.1016/j.mce.2019.110698
11988  Gogola J, Hoffmann M, Ptak A.  Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate IGF1 secretion by adult ovarian granulosa cell tumor spheroids and thereby increase proliferation of non-cancer ovarian granulosa cells.  Toxicol In Vitro  2020    PubMed ID: 31923581   DOI: 10.1016/j.tiv.2020.104769
12055  Wu G, Yang Z, Chen Y, Li X, Yang J, Yin T.  Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome.  Mol. Cell. Endocrinol.  2020    PubMed ID: 32070768   DOI: 10.1016/j.mce.2020.110760
12068  Wang X, Zhang X, Dang Y, Li D, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y, Chen ZJ.  Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1.  Nucleic Acids Res.  2020    PubMed ID: 32112110   DOI: 10.1093/nar/gkaa127
12093  Nishigaki A, Kido T, Kida N, Kakita-Kobayashi M, Tsubokura H, Hisamatsu Y, Okada H.  Resveratrol protects mitochondrial quantity by activating SIRT1/PGC-1α expression during ovarian hypoxia.  Reprod. Med. Biol.  2020    PubMed ID: 32273826   DOI: 10.1002/rmb2.12323
12161  Xiangmin Lv, Chunbo He, Cong Huang , Guohua Hua, Xingcheng Chen, Barbara K.Timm, Victoria M.Maclin, Abigail A.Haggerty, Shelly K.Aust, Denae M.Golden, Bhavana J.Dave, Yun-An Tseng, Li Chen, Hongbo Wang, Peichao Chen, David L.Klinkebiel, Adam R.Karpf, Jixin Dong, Ronny I.Drapkin, Bo R.Rueda, John S.Davis, Cheng Wang  Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features  Science Bulletin  2020      DOI: 10.1016/j.scib.2020.03.040
12495  Silber M, Miller I, Bar-Joseph H, Ben-Ami I, Shalgi R.  Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models  J Endocrinol  2020  244(2):297-308  PubMed ID: 31661672   DOI: 10.1530/JOE-19-0297
12995  Jin H, Lee B, Luo Y, Choi Y, Choi EH, Jin H, Kim KB, Seo SB, Kim YH, Lee HH, Kim KP, Lee K, Bae J.  FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku.  Nat Commun  2020    PubMed ID: 32332759   DOI: 10.1038/s41467-020-15748-1
13030  Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y.  MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency.  J Cell Physiol  2020    PubMed ID: 32391592   DOI: 10.1002/jcp.29725
13187  Lin YY, Sun D, Wu YL.  Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells.  Chin J Physiol  2020    PubMed ID: 32859885   DOI: 10.4103/CJP.CJP_44_20
13507  Lee SY, Kang YJ, Kwon J, Nishi Y, Yanase T, Lee KA, Koong MK.  miR-4463 regulates aromatase expression and activity for 17β-estradiol synthesis in response to follicle-stimulating hormone  Clin Exp Reprod Med  2020  47(3):194-206  PubMed ID: 32854459   DOI: 10.5653/cerm.2019.03412
14808  Shin E, Jin H, Suh DS, Luo Y, Ha HJ, Kim TH, Hahn Y, Hyun S, Lee K, Bae J.  An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2  EMBO J  2020  39(24):e104719.  PubMed ID: 33215742   DOI: 10.15252/embj.2020104719
16122  Man Y, Zhao R, Gao X, Liu Y, Zhao S, Lu G, Chan WY, Leung PCK, Bian Y.  TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study  Front Endocrinol (Lausanne)   2020  11:615846  PubMed ID: 33716953   DOI: 10.3389/fendo.2020.615846
17005  Du J, Lin X, Wu R, Gao Z, Du Y, Liao Y, Quan S.  miR-424 suppresses proliferation and promotes apoptosis of human ovarian granulosa cells by targeting Apelin and APJ expression  Am J Transl Res  2020  12(7):3660-3673  PubMed ID: 32774725  
17009  Tremblay PG, Sirard MA.  Gene analysis of major signaling pathways regulated by gonadotropins in human ovarian granulosa tumor cells (KGN)  Biol Reprod  2020  103(3):583-598  PubMed ID: 32427331   DOI: 10.1093/biolre/ioaa079
17023  Li Y, Zhang J, Liu YD, Zhou XY, Chen X, Zhe J, Zhang QY, Zhang XF, Chen YX, Wang Z, Chen SL.  Long non-coding RNA TUG1 and its molecular mechanisms in polycystic ovary syndrome  RNA Biol  2020  17(12):1798-1810  PubMed ID: 32559120   DOI: 10.1080/15476286.2020.1783850
17026  Miller I, Bar-Joseph H, Nemerovsky L, Ben-Ami I, Shalgi R.  Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features  J Endocrinol  2020  245(2):291-300  PubMed ID: 32171180   DOI: 10.1530/JOE-19-0603
11293  Gogola J, Hoffmann M, Ptak A.  Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors.  Chemosphere  2019    PubMed ID: 30414542   DOI: 10.1016/j.chemosphere.2018.11.018
11466  Buck T, Hack CT, Berg D, Berg U, Kunz L, Mayerhofer A.  The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells.  Sci Rep  2019    PubMed ID: 30837663   DOI: 10.1038/s41598-019-40329-8
11481  Li Y, Xiang Y, Song Y, Wan L, Yu G, Tan L.  Dysregulated miR-142, -33b, and -423 in granulosa cells target TGFBR1 and SMAD7: a possible role in polycystic ovary syndrome.  Mol. Hum. Reprod.  2019    PubMed ID: 30865275   DOI: 10.1093/molehr/gaz014
11596  Lv X, He C, Huang C, Wang H, Hua G, Wang Z, Zhou J, Chen X, Ma B, Timm BK, Maclin V, Dong J, Rueda BR, Davis JS, Wang C.  Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development.  FASEB J.  2019    PubMed ID: 31199671   DOI: 10.1096/fj.201900179RR
11734  Lin PH, Chang CC, Wu KH, Shih CK, Chiang W, Chen HY, Shih YH, Wang KL, Hong YH, Shieh TM, Hsia SM.  Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-like Symptoms.  Biomolecules  2019    PubMed ID: 31370285   DOI: 10.3390/biom9080327
11752  Li Y, Liu YD, Zhou XY, Chen SL, Chen X, Zhe J, Zhang J, Zhang QY, Chen YX.  MiR-29a regulates the proliferation, aromatase expression, and estradiol biosynthesis of human granulosa cells in polycystic ovary syndrome.  Mol. Cell. Endocrinol.  2019    PubMed ID: 31421163   DOI: 10.1016/j.mce.2019.110540
11753  Bagnjuk K, Kast VJ, Tiefenbacher A, Kaseder M, Yanase T, Burges A, Kunz L, Mayr D, Mayerhofer A.  Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors - implications from studies in KGN.  J Ovarian Res  2019    PubMed ID: 31412918   DOI: 10.1186/s13048-019-0549-6
11754  He T, Sun Y, Zhang Y, Zhao S, Zheng Y, Hao G, Shi Y.  MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN.  Reprod. Biol. Endocrinol.  2019    PubMed ID: 31421682   DOI: 10.1186/s12958-019-0505-8
11876  Hack CT, Buck T, Bagnjuk K, Eubler K, Kunz L, Mayr D, Mayerhofer A.  A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells.  Antioxidants (Basel)  2019    PubMed ID: 31671815   DOI: 10.3390/antiox8110518
11961  Jung DH, Hwang JT, Pyun BJ, Yu SY, Ko BS.  Assessment of the Aromatase Inhibitory Activity of Ma-Huang-Tang (MHT) and Its Active Compounds.  Evid Based Complement Alternat Med  2019    PubMed ID: 31929813   DOI: 10.1155/2019/4809846
12493  Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S, Yan Q.  Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome  J Cell Physiol  2019  234(5):7435-7447  PubMed ID: 30580448   DOI: 10.1002/jcp.27501
12494  Huang X, She L, Luo X, Huang S, Wu J.  MiR-222 promotes the progression of polycystic ovary syndrome by targeting p27 Kip1  Pathol Res Pract  2019  215(5):918-923.  PubMed ID: 30718101   DOI: 10.1016/j.prp.2019.01.038
12496  Liu Y, Wang Y, Wang F, Pan J, Xu J, Li J, Zhou C, Ding G, Wu Y, Liu X, Sheng J, Huang H.  Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants  Sci China Life Sci  2019  62(2):257-267  PubMed ID: 30267260   DOI: 10.1007/s11427-018-9379-x
14276  Chen H, Crosley P, Azad AK, Gupta N, Gokul N, Xu Z, Weinfeld M, Postovit LM, Pangas SA, Hitt MM, Fu Y.  RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line  Int J Mol Sci  2019  20(14):3471  PubMed ID: 31311113   DOI: 10.3390/ijms20143471
17004  J Gogola, M Hoffmann, S Nimpsz, A Ptak  EP859 Endocrine-disrupting chemicals present in human follicular fluid disrupt granulosa cell tumors E2 secretion dependent on estrogen metabolism potential  ePoster  2019      DOI: 10.1136/ijgc-2019-esgo.908
17010  P Giamougiannis, R Grabowska, CLM Morais, A Anagnostopoulos, L Whitham, E Tingi, G Owens, P Hadjiyiannakis, NJ Wood, PL Martin-Hirsch, FL Martin  EP857 Distinguishing benign vs. cancer states in ovary based on spectrochemical analysis of ascites: a budget omics approach  ePoster  2019      DOI: 10.1136/ijgc-2019-esgo.906
17025  Xu L, Wang W, Zhang X, Ke H, Qin Y, You L, Li W, Lu G, Chan WY, Leung PCK, Zhao S, Chen ZJ.  Palmitic acid causes insulin resistance in granulosa cells via activation of JNK  J Mol Endocrinol  2019  62(4):197-206  PubMed ID: 30913535   DOI: 10.1530/JME-18-0214
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14259  Jin H, Won M, Shin E, Kim HM, Lee K, Bae J.  EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells  Biochem Biophys Res Commun  2017  482(4):877-882  PubMed ID: 27890615   DOI: 10.1016/j.bbrc.2016.11.127
14260  Haltia UM, Andersson N, Yadav B, Färkkilä A, Kulesskiy E, Kankainen M, Tang J, Bützow R, Riska A, Leminen A, Heikinheimo M, Kallioniemi O, Unkila-Kallio L, Wennerberg K, Aittokallio T, Anttonen M.  Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells  Gynecol Oncol  2017  144(3):621-630  PubMed ID: 28104295   DOI: 10.1016/j.ygyno.2016.12.016
14262  Mathew L, Gaikwad A, Gonzalez A, Nugent EK, Smith JA.  Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models  Integr Cancer Ther  2017  16(3):300-307  PubMed ID: 28438054   DOI: 10.1177/1534735417704948
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12654  Huang X, Liu C, Hao C, Tang Q, Liu R, Lin S, Zhang L, Yan W.  Identification of altered microRNAs and mRNAs in the cumulus cells of PCOS patients: miRNA-509-3p promotes oestradiol secretion by targeting MAP3K8  Reproduction  2016  151(6):643-55  PubMed ID: 27001999   DOI: 10.1530/REP-16-0071
12972  Fang Y, Lu X, Liu L, Lin X, Sun M, Fu J, Xu S, Tan Y.  Vascular endothelial growth factor induces anti‑Müllerian hormone receptor 2 overexpression in ovarian granulosa cells of in vitro fertilization/intracytoplasmic sperm injection patients  Mol Med Rep  2016  13(6):5157-62.  PubMed ID: 27109000   DOI: 10.3892/mmr.2016.5173
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7428  He C, Lv X, Hua G, Lele SM, Remmenga S, Dong J, Davis JS, Wang C.  YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression.  Oncogene  2015  34:6040-54  PubMed ID: 25798835   DOI: 10.1038/onc.2015.52
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10297  Jana Ernst, Johann-Christoph Jann, Ronald Biemann, Holger M Koch, Bernd Fischer  Effects of the Environmental Contaminants DEHP and TCDD on Estradiol Synthesis and Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor Signalling in the Human Granulosa Cell Line KGN  Mol Hum Reprod  2014  20(9):919-28  PubMed ID: 24950685   DOI: 10.1093/molehr/gau045
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17011  Egli M, Leeners B, Kruger TH.  Prolactin secretion patterns: basic mechanisms and clinical implications for reproduction  Reproduction  2010  140(5):643-54  PubMed ID: 20733016   DOI: 10.1530/REP-10-0033
8474  Ohno S, Yukinawa F, Noda M, Nakajin S.  Mono-(2-ethylhexyl) phthalate induces NR4A subfamily and GIOT-1 gene expression, and suppresses CYP19 expression in human granulosa-like tumor cell line KGN.  Toxicol. Lett.  2009  191:353-9  PubMed ID: 19822197   DOI: 10.1016/j.toxlet.2009.10.004
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17007  KR Gissum, S Drageset, I Vistad, J Hoel, R Strand, L Bjørge  EP858 What you should know about tumor reductive surgery in advanced ovarian cancer – clinical recommendations from a patient perspective  ePoster    2019    DOI: 10.1136/ijgc-2019-esgo.907



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