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Cell No. : Cell Name
RCB1154 : KGN  update : 2024/06/12
CommentHuman cell line derived from ovarian granulosa cell tumor. Aromatase activity is increased by stimulation of FSH and hMG.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Nishi, Y. & Nawata, H.
Originator Nishi, Yoshihiro & Nawata, Hajime
Year of deposit 1995
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 69 years
Tissue ovary, peritoneum
Disease name granulosa cell tumor
Classification cancer
Year of origin 1993
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_0375
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM/HamF12 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 43-46(50) : 43(1),44(1),45(45),46(3)
STR(human) OK
deposit info
lot info
D5S818 D13S317 D7S820 D16S539 vWA TH01 Amelogenin TPOX CSF1PO
13 9 11 10,12 17 9 X 8,9 10,12
deposit info
lot info
Reference information Reference 10
User's Publication 154

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4938  Bao B, Jiang J, Yanase T, Nishi Y, Morgan JR.  Connexon-mediated cell adhesion drives microtissue self-assembly.  FASEB J  2011  25(1):255-64  PubMed ID: 20876208   DOI: 10.1096/fj.10-155291
4936  Kwintkiewicz J, Nishi Y, Yanase T, Giudice LC.  Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells.  Environ Health Perspect  2010  118(3):400-6  PubMed ID: 20064783   DOI: 10.1289/ehp.0901161
4935  Jääskeläinen M, Kyrönlahti A, Anttonen M, Nishi Y, Yanase T, Secchiero P, Zauli G, Tapanainen JS, Heikinheimo M, Vaskivuo TE.  TRAIL pathway components and their putative role in granulosa cell apoptosis in the human ovary.  Differentiation  2009  77(4):369-76  PubMed ID: 19281785   DOI: 10.1016/j.diff.2008.12.001
4934  Mottershead DG1, Pulkki MM, Muggalla P, Pasternack A, Tolonen M, Myllymaa S, Korchynskyi O, Nishi Y, Yanase T, Lun S, Juengel JL, Laitinen M, Ritvos O.  Characterization of recombinant human growth differentiation factor-9 signaling in ovarian granulosa cells.  Mol Cell Endocrinol  2008  283(1-2):58-67  PubMed ID: 18162287   DOI: 10.1016/j.mce.2007.11.007
4933  Wu Y, Ghosh S, Nishi Y, Yanase T, Nawata H, Hu Y.  The orphan nuclear receptors NURR1 and NGFI-B modulate aromatase gene expression in ovarian granulosa cells: a possible mechanism for repression of aromatase expression upon luteinizing hormone surge.  Endocrinology  2005  146(1):237-46  PubMed ID: 15486232   DOI: 10.1210/en.2004-0889
4932  Chu S, Nishi Y, Yanase T, Nawata H, Fuller PJ.  Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells.  Mol Endocrinol  2004  18(8):1919-28  PubMed ID: 15155785   DOI: 10.1210/me.2004-0021
4930  Fujii A, Harada T, Yamauchi N, Iwabe T, Nishi Y, Yanase T, Nawata H, Terakawa N.  Interleukin-8 gene and protein expression are up-regulated by interleukin-1beta in normal human ovarian cells and a granulosa tumor cell line.  Fertil Steril  2003  79(1):151-7  PubMed ID: 12524080   DOI: 10.1016/s0015-0282(02)04408-4
4931  Mukasa C, Nomura M, Tanaka T, Tanaka K, Nishi Y, Okabe T, Goto K, Yanase T, Nawata H.  Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells.  Endocrinology  2003  144(4):1603-11  PubMed ID: 12639945   DOI: 10.1210/en.2002-220978
4928  Nishi Y, Yanase T, Mu Y, Oba K, Ichino I, Saito M, Nomura M, Mukasa C, Okabe T, Goto K, Takayanagi R, Kashimura Y, Haji M, Nawata H.  Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor.  Endocrinology  2001  42(1):437-45  PubMed ID: 11145608   DOI: 10.1210/endo.142.1.7862
4929  Saitoh M, Yanase T, Morinaga H, Tanabe M, Mu YM, Nishi Y, Nomura M, Okabe T, Goto K, Takayanagi R, Nawata H.  Tributyltin or triphenyltin inhibits aromatase activity in the human granulosa-like tumor cell line KGN.  Biochem Biophys Res Commun  2001  289(1):198-204  PubMed ID: 11708799   DOI: 10.1006/bbrc.2001.5952

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User's Publication
19902  Chen Q, Chen Q, Song Y, Xiang Y, Li Q, Sang Y, Zhang L, Bai L, Zhu Y.  Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction  Mol Cell Endocrinol  2024  580:112084  PubMed ID: 37923054   DOI: 10.1016/j.mce.2023.112084
21745  Yanase T.  Reflections and expectations of an endocrinologist and diabetologist on the launch of a new, board-certified Endocrinology, Diabetes and Metabolism specialist system pioneered by the JES and the JDS.  Endocr J  2024  71(5):429-435  PubMed ID: 38777761   DOI: 10.1507/endocrj.EJ20231005
21750  Hao J, Li T, Heinzelmann M, Moussaud-Lamodière E, Lebre F, Krjutškov K, Damdimopoulos A, Arnelo C, Pettersson K, Alfaro-Moreno E, Lindskog C, van Duursen M, Damdimopoulou P.  Effects of chemical in vitro activation versus fragmentation on human ovarian tissue and follicle growth in culture.  Hum Reprod Open  2024  2024(3):hoae028  PubMed ID: 38803550   DOI: 10.1093/hropen/hoae028
21757  Li T, Björvang RD, Hao J, Di Nisio V, Damdimopoulos A, Lindskog C, Papaikonomou K, Damdimopoulou P.  Persistent organic pollutants dysregulate energy homeostasis in human ovaries in vitro.  Environ Int  2024  187:108710  PubMed ID: 38701644   DOI: 10.1016/j.envint.2024.108710
21795  Yang G, Zhang B, Xu M, Wu M, Lin J, Luo Z, Chen Y, Hu Q, Huang G, Hu H.  Improving Granulosa Cell Function in Premature Ovarian Failure with Umbilical Cord Mesenchymal Stromal Cell Exosome-Derived hsa_circ_0002021.  Tissue Eng Regen Med  2024    PubMed ID: 38842768   DOI: 10.1007/s13770-024-00652-2
17738  Qin L, Sitticharoon C, Petyim S, Keadkraichaiwat I, Sririwichitchai R, Maikaew P, Churintaraphan M.  A Longitudinal Study of the Relationship of Adiponectin with Reproduction in Infertile Women Undergoing IVF/ICSI Treatment, and an Experimental Study in Human Granulosa Cells  Life (Basel)  2023  13(4):994  PubMed ID: 37109523   DOI: 10.3390/life13040994
19900  Wu Q, Chen M, Li Y, Zhao X, Fan C, Dai Y.  Paeoniflorin Alleviates Cisplatin-Induced Diminished Ovarian Reserve by Restoring the Function of Ovarian Granulosa Cells via Activating FSHR/cAMP/PKA/CREB Signaling Pathway  Molecules  2023  28(24):8123  PubMed ID: 38138611   DOI: 10.3390/molecules28248123
19901  Vann K, Weidner AE, Walczyk AC, Astapova O.  Paxillin knockout in mouse granulosa cells increases fecundity†  Biol Reprod  2023  109(5):669-683  PubMed ID: 37552051   DOI: 10.1093/biolre/ioad093
19903  Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM.  Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression  Elife  2023  12:e83291  PubMed ID: 36803359   DOI: 10.7554/eLife.83291
19905  Lee DH, Park H, You JH, Seok J, Kwon DW, Kim YR, Kim GJ.  Increased IGFBP2 Levels by Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a TAA-Injured Rat Model via AMPK Signaling Pathway  Int J Mol Sci  2023  24(22):16531  PubMed ID: 38003735   DOI: 10.3390/ijms242216531
19907  Ji R, Jia F, Chen X, Gao Y, Yang J.  Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation  Phytother Res  2023  1405-1421  PubMed ID: 36786429   DOI: 10.1002/ptr.7749
19908  Bao D, Gao L, Xin H, Wang L.  lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure  J Ovarian Res  2023  16(1):65  PubMed ID: 37005611   DOI: 10.1186/s13048-023-01121-5
19909  Yan MQ, Zhu BH, Liu XH, Yang YM, Duan XY, Wang Y, Sun H, Feng M, Li T, Liu XM.  Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway  Cell Death Dis  2023  14(11):779  PubMed ID: 38012141   DOI: 10.1038/s41419-023-06312-y
19910  Wan S, Chen Q, Xiang Y, Sang Y, Tang M, Song Y, Feng G, Ye B, Bai L, Zhu Y.  Interleukin-1 increases cyclooxygenase-2 expression and prostaglandin E2 production in human granulosa-lutein cell via nuclear factor kappa B/P65 and extracellular signal-regulated kinase 1/2 signaling pathways  Mol Cell Endocrinol  2023  566-567:111891  PubMed ID: 36801432   DOI: 10.1016/j.mce.2023.111891
19911  Le Sauteur-Robitaille J, Crosley P, Hitt M, Jenner AL, Craig M.  Mathematical modeling predicts pathways to successful implementation of combination TRAIL-producing oncolytic virus and PAC-1 to treat granulosa cell tumors of the ovary  Cancer Biol Ther  2023  24(1):2283926  PubMed ID: 38010777   DOI: 10.1080/15384047.2023.2283926
20992  Li T, Vazakidou P, Leonards PEG, Damdimopoulos A, Panagiotou EM, Arnelo C, Jansson K, Pettersson K, Papaikonomou K, van Duursen M, Damdimopoulou P.  Identification of Biomarkers and Outcomes of Endocrine Disruption in Human Ovarian Cortex Using In Vitro Models.  Toxicology  2023    PubMed ID: 36621641   DOI: 10.1016/j.tox.2023.153425
21017  Gogola-Mruk J, Tworzydło W, Krawczyk K, Marynowicz W, Ptak A.  Visfatin induces ovarian cancer resistance to anoikis by regulating mitochondrial activity.  Endocrine  2023    PubMed ID: 36658296   DOI: 10.1007/s12020-023-03305-x
21099  Gogola-Mruk J, Marynowicz W, Krawczyk K, Ptak A.  Visfatin increases the invasive potential of ovarian granulosa tumor spheroids by reprogramming glucose metabolism.  Reproduction  2023    PubMed ID: 36880885   DOI: 10.1530/REP-22-0443
21157  Yan MQ, Wang Y, Wang Z, Liu XH, Yang YM, Duan XY, Sun H, Liu XM.  Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells.  J Endocr Soc  2023  7(5):bvad034  PubMed ID: 36936714   DOI: 10.1210/jendso/bvad034
21201  Tarvainen I, Soto DA, Laws MJ, Björvang RD, Damdimopoulos A, Roos K, Li T, Kramer S, Li Z, Lavogina D, Visser N, Kallak TK, Lager S, Gidlöf S, Edlund E, Papaikonomou K, Öberg M, Olovsson M, Salumets A, Velthut-Meikas A, Flaws JA, Damdimopoulou P.  Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro.  Reprod Toxicol  2023  119:108393  PubMed ID: 37160244   DOI: 10.1016/j.reprotox.2023.108393
21321  Marynowicz W, Borski N, Flis Z, Ptak A, Molik E.  Orotic acid induces apoptotic death in ovarian adult granulosa tumour cells and increases mitochondrial activity in normal ovarian granulosa cells.  Reprod Biol  2023  23(3):100790  PubMed ID: 37478515   DOI: 10.1016/j.repbio.2023.100790
21341  Zhou Y, Yuan F, Jia C, Chen F, Li F, Wang L.  MiR-497-3p induces Premature ovarian failure by targeting KLF4 to inactivate Klotho/PI3K/AKT/mTOR signaling pathway.  Cytokine  2023  170:156294  PubMed ID: 37549487   DOI: 10.1016/j.cyto.2023.156294
21372  Chiang YF, Lin IC, Huang KC, Chen HY, Ali M, Huang YJ, Hsia SM.  Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.  Biomed Pharmacother  2023  166:115327  PubMed ID: 37619480   DOI: 10.1016/j.biopha.2023.115327
21438  Liu D, Guan X, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L, Li K.  Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency.  J Ovarian Res  2023  16(1):203  PubMed ID: 37848988   DOI: 10.1186/s13048-023-01266-3
21475  Zhang L, Liu K, Liu Z, Tao H, Fu X, Hou J, Jia G, Hou Y.  Fetal hypoxia expose caused autophagy in ovary granulosa cells via PI3K/Akt/FoxO1 pathway and mitigated by melatonin Subheading.  J Adv Res  2023    PubMed ID: 37956860   DOI: 10.1016/j.jare.2023.11.008
21573  Park JE, Lee SG, Lee SJ, Yu WJ, Kim JM.  Downregulation of the Expression of Steroidogenic Acute Regulatory Protein and Aromatase in Steroidogenic KGN Human Granulosa Cells after Exposure to Bisphenol A.  Dev Reprod  2023  27(4):185-193  PubMed ID: 38292236   DOI: 10.12717/DR.2023.27.4.185
17625  Shi CY, Xu JJ, Li C, Yu JL, Wu YT, Huang HF.  A PPARG Splice Variant in Granulosa Cells Is Associated with Polycystic Ovary Syndrome  J Clin Med  2022  11(24):7285  PubMed ID: 36555903   DOI: 10.3390/jcm11247285
17690  Olivia Cardinal, Chloé Burlot, Yangxin Fu, Powel Crosley, Mary Hitt, Morgan Craig, Adrianne L. Jenner  Establishing combination PAC‐1 and TRAIL regimens for treating ovarian cancer based on patient‐specific pharmacokinetic profiles usingin silicoclinical trials  Computational and Systems Oncology  2022  2    DOI: 10.1002/cso2.1035
19904  Kaseder M, Schmid N, Eubler K, Goetz K, Müller-Taubenberger A, Dissen GA, Harner M, Wanner G, Imhof A, Forne I, Mayerhofer A.  Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells  Mol Hum Reprod  2022  28(10):gaac030  PubMed ID: 35944223   DOI: 10.1093/molehr/gaac030
19912  Chen YC, Yeh YC, Lin YF, Au HK, Hsia SM, Chen YH, Hsieh RH.  Aspartame Consumption, Mitochondrial Disorder-Induced Impaired Ovarian Function, and Infertility Risk  Int J Mol Sci  2022  23(21):12740  PubMed ID: 36361530   DOI: 10.3390/ijms232112740
20340  Niu Q, Shi J, Gao Q, Fu J.  WNT5A Enhances LH-Mediated Expression of HAS2 in Granulosa Cells.  Reprod Sci  2022    PubMed ID: 34542891   DOI: 10.1007/s43032-021-00736-7
20535  Zhang L, Mao B, Zhao X, Yuan Y, Wang W, Lin S.  Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure.  Bioengineered  2022  13(2):2173-2180  PubMed ID: 35034562   DOI: 10.1080/21655979.2021.2023802
20543  Mi X, Jiao W, Yang Y, Qin Y, Chen ZJ, Zhao S.  HGF Secreted by Mesenchymal Stromal Cells Promotes Primordial Follicle Activation by Increasing the Activity of the PI3K-AKT Signaling Pathway.  Stem Cell Rev Rep  2022    PubMed ID: 35089464   DOI: 10.1007/s12015-022-10335-x
16239  Cluzet V, Devillers MM, Petit F, Pierre A, Giton F, Airaud E, L'Hôte D, Leary A, Genestie C, Treilleux I, Mayeur A, Katzenellenbogen JA, Kim SH, Cohen-Tannoudji J, Chauvin S, Guigon CJ.  Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα-dependent mechanism  J Pathol  2022  256(3):335-348  PubMed ID: 34860414   DOI: 10.1002/path.5843
20528  Shao T, Ke H, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y, Zhao S.  Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1.  Autophagy  2022  1-15  PubMed ID: 35025698   DOI: 10.1080/15548627.2021.2005415
20651  Asma A, Marc-André S.  Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN).  Int J Mol Sci  2022  23(6)  PubMed ID: 35328408   DOI: 10.3390/ijms23062988
16505  Nishigaki A, Tsubokura H, Ishida M, Hashimoto Y, Yoshida A, Hisamatsu Y, Tsuzuki-Nakao T, Murata H, Okada H.  NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary  Reprod Med Biol  2022  21(1):e12437  PubMed ID: 35386369   DOI: 10.1002/rmb2.12437
16767  Chen H, Chen Q, Zhu Y, Yuan K, Li H, Zhang B, Jia Z, Zhou H, Fan M, Qiu Y, Zhuang Q, Lei Z, Li M, Huang W, Liang L, Yan Q, Wang C.  MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development  Front Genet  2022  13:736988  PubMed ID: 35309143   DOI: 10.3389/fgene.2022.736988
20777  Panagiotou EM, Draskau MK, Li T, Hirschberg AL, Svingen T, Damdimopoulou P.  AOP Key Event Relationship Report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles.  Reprod Toxicol  2022    PubMed ID: 35868514   DOI: 10.1016/j.reprotox.2022.07.004
20804  Choi Y, Luo Y, Lee S, Jin H, Yoon HJ, Hahn Y, Bae J, Lee HH.  FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations.  Nucleic Acids Res  2022  50(15):8929-8946  PubMed ID: 35920317   DOI: 10.1093/nar/gkac673
17003  Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J.  Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN  Arch Biochem Biophys  2022  715:109094  PubMed ID: 34813774   DOI: 10.1016/
17013  Zhang QY, Li X, Zhou XY, Li Y, Zhang J, Zhang XF, Liu YD, Chen YX, Wu XM, Ma LZ, Chen X, Chen SL.  Study of differential proteomics in granulosa cells of premature ovarian insufficiency (POI) and the roles and mechanism of RAC1 in granulosa cells  Mol Cell Endocrinol  2022  555:111719  PubMed ID: 35850487   DOI: 10.1016/j.mce.2022.111719
17015  Kang W, Ishida E, Amita M, Tatsumi K, Yonezawa H, Yohtsu M, Katano D, Onozawa K, Kaneko E, Iwasaki W, Naito N, Yamada M, Kawano N, Miyado M, Sato B, Saito H, Saito T, Miyado K.  Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility  Nutrients  2022  14(10):2156  PubMed ID: 35631296   DOI: 10.3390/nu14102156
20854  Wang W, Hao J, Shi Y.  IL23 suppresses proliferation and promotes apoptosis of human granulosa-like tumor cell line KGN by targeting the androgen receptor signal pathway.  Gynecol Endocrinol  2022  1-6  PubMed ID: 36123810   DOI: 10.1080/09513590.2022.2123914
20902  Arjoune A, Sirard MA.  The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors.  Sci Rep  2022  12(1):17539  PubMed ID: 36266374   DOI: 10.1038/s41598-022-21162-y
20984  Gogola-Mruk J, Krawczyk K, Marynowicz W, Rokita M, Nimpsz S, Ptak A.  Bisphenols S and F drive ovarian granulosa cell tumor invasion via a metabolic switch.  Toxicol Lett  2022    PubMed ID: 36584861   DOI: 10.1016/j.toxlet.2022.12.011
21027  Zheng Q, Liu M, Fu J.  ALG2 inhibits the epithelial-to-mesenchymal transition and stemness of ovarian granulosa cells through the Wnt/β-catenin signaling pathway in polycystic ovary syndrome.  Reprod Biol  2022  22(4):100706  PubMed ID: 36327672   DOI: 10.1016/j.repbio.2022.100706
17383  Chen H, Fu Y, Guo Z, Zhou X.  MicroRNA-29c-3p participates in insulin function to modulate polycystic ovary syndrome via targeting Forkhead box O 3  Bioengineered  2022  13(2):4361-4371  PubMed ID: 35142592   DOI: 10.1080/21655979.2022.2033014
13389  Li D, Wang X, Dang Y, Zhang X, Zhao S, Lu G, Chan WY, Leung PCK, Qin Y.  lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1.  Mol Ther Nucleic Acids  2021    PubMed ID: 33335798   DOI: 10.1016/j.omtn.2020.10.041
20143  Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y.  LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA.  Cell Death Discov  2021  7(1):107  PubMed ID: 33993190   DOI: 10.1038/s41420-021-00493-1
20306  Jiao X, Zhang X, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ, Chen W, Qin Y.  Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells.  Clin Transl Med  2021  11(6):e448  PubMed ID: 34185428   DOI: 10.1002/ctm2.448
15496  Kotomura N, Harada N, Shimono Y, Ishihara S.  Transcriptional regulation of CYP1 9 by cohesin-mediated chromosome tethering in human granulosa cells  Biochem Biophys Rep  2021  27:101086  PubMed ID: 34368471   DOI: 10.1016/j.bbrep.2021.101086
15497  Xu X, Song X, Xu X, Zheng Y, Xu L, Shen L.  Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy  Aging (Albany NY)   2021  13(8):11774-11785  PubMed ID: 33883304   DOI: 10.18632/aging.202872
15513  Li Y, Liu YD, Zhou XY, Zhang J, Wu XM, Yang YZ, Chen YX, Zhang XF, Li X, Ma LZ, Wang Z, Chen SL.  Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism  Mol Cell Endocrinol  2021  535:111392  PubMed ID: 34246727   DOI: 10.1016/j.mce.2021.111392
20383  Xu L, Xiong F, Bai Y, Xiao J, Zhang Y, Chen J, Li Q.  Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome.  Reprod Biol Endocrinol  2021  19(1):167  PubMed ID: 34740363   DOI: 10.1186/s12958-021-00839-5
20386  Zheng C, Liu S, Qin Z, Zhang X, Song Y.  LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis.  J Ovarian Res  2021  14(1):151  PubMed ID: 34740384   DOI: 10.1186/s13048-021-00905-x
20395  Li D, Xu W, Wang X, Dang Y, Xu L, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y.  lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1.  Mol Ther Nucleic Acids  2021  26:1092-1106  PubMed ID: 34786213   DOI: 10.1016/j.omtn.2021.10.015
20429  Zhou XY, Zhang J, Li Y, Chen YX, Wu XM, Li X, Zhang XF, Ma LZ, Yang YZ, Zheng KM, Liu YD, Wang Z, Chen SL.  Advanced Oxidation Protein Products Induce G1/G0-Phase Arrest in Ovarian Granulosa Cells via the ROS-JNK/p38 MAPK-p21 Pathway in Premature Ovarian Insufficiency.  Oxid Med Cell Longev  2021  2021:6634718  PubMed ID: 34367464   DOI: 10.1155/2021/6634718
15886  Wu YX, Lin YS, Li SC, Yao X, Cheng M, Zhu L, Liu HY.  microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor  Reprod Biol Endocrinol  2021  19(1):170  PubMed ID: 34814928   DOI: 10.1186/s12958-021-00850-w
20485  Tremblay PG, Fortin C, Sirard MA.  Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin.  J Ovarian Res  2021  14(1):178  PubMed ID: 34930403   DOI: 10.1186/s13048-021-00934-6
20719  Schmid N, Dietrich KG, Forne I, Burges A, Szymanska M, Meidan R, Mayr D, Mayerhofer A.  Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors.  Int J Mol Sci  2021  22(4)  PubMed ID: 33669567   DOI: 10.3390/ijms22042047
16858  J Gogola-Mruk, K Krawczyk, W Marynowicz, A Ptak  210 Visfatin increases invasion in human adult granulosa tumor cell line by stimulation of glucose metabolism reprogramming  Ovarian cancer  2021      DOI: 10.1136/ijgc-2021-esgo.357
16859  I Rodolakis, A Prodromidou, M Sotiropoulou, M Liontos, D Haidopoulos, A Bamias, D Loutradis, N Thomakos, A Rodolakis  217 The impact of chemotherapy response score and lymphocytic infiltration in patients with ovarian cancer treated with neoadjuvant chemotherapy  Ovarian cancer  2021      DOI: 10.1136/ijgc-2021-esgo.358
16872  G Cass, R Lewes, J Pawade, C Newton  219 Skin capillary density as a novel biomarker of cytotoxic and bevacizumab treatment in ovarian cancer: a prospective clinical trial  Ovarian cancer  2021      DOI: 10.1136/ijgc-2021-esgo.359
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